V Toder

Summary

Affiliation: Tel Aviv University
Country: Israel

Publications

  1. pmc NF-kappa B DNA-binding activity in embryos responding to a teratogen, cyclophosphamide
    Arkady Torchinsky
    Department of Embryology and Teratology, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
    BMC Dev Biol 2:2. 2002
  2. pmc Teratogen-induced alterations in microRNA-34, microRNA-125b and microRNA-155 expression: correlation with embryonic p53 genotype and limb phenotype
    Keren Gueta
    Department of Cell and Developmental Biology, Sackler School of Medicine, Tel Aviv University, Ramat Aviv, Tel Aviv, 69978, Israel
    BMC Dev Biol 10:20. 2010
  3. ncbi request reprint The role of pro- and anti-apoptotic molecular interactions in embryonic maldevelopment
    V Toder
    Department of Embryology and Teratology, Sackler School of Medicine, Tel Aviv University, Ramat Aviv, Tel Aviv, Israel
    Am J Reprod Immunol 48:235-44. 2002
  4. pmc TNF-alpha in pregnancy loss and embryo maldevelopment: a mediator of detrimental stimuli or a protector of the fetoplacental unit?
    V Toder
    Department of Embryology and Teratology, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
    J Assist Reprod Genet 20:73-81. 2003
  5. ncbi request reprint Apoptosis in the uterus of mice with pregnancy loss
    S Savion
    Department of Embryology and Teratology, Sackler School of Medicine, Tel Aviv University, Ramat Aviv, Tel Aviv, Israel
    Am J Reprod Immunol 47:118-27. 2002
  6. ncbi request reprint A possible role for granulocyte macrophage-colony stimulating factor in modulating teratogen-induced effects
    S Savion
    Department of Embryology and Teratology, Sackler School of Medicine, Tel Aviv University, Ramat Aviv, Israel
    Teratog Carcinog Mutagen 19:171-82. 1999
  7. ncbi request reprint Diabetes teratogenicity is accompanied by alterations in macrophages and T cell subpopulations in the uterus and lymphoid organs
    S Savion
    Department of Cell and Developmental Biology, Sackler School of Medicine, Tel Aviv University, Ramat Aviv, Tel Aviv 69978, Israel
    Int Immunopharmacol 4:1319-27. 2004
  8. ncbi request reprint TGFbeta2 in embryos with inborn anomalies: effect of maternal immunopotentiation
    I Ivnitsky
    Department of Embryology and Teratology Sackler School of Medicine, Tel Aviv University, Israel
    Am J Reprod Immunol 45:41-51. 2001
  9. ncbi request reprint Expression of tumor necrosis factor-alpha in the pregnant uterus of diabetic mice: effect of maternal immunopotentiation
    A Flein
    Department of Embryology and Teratology, Sackler School of Medicine, Tel Aviv University, Ramat Aviv, Israel
    Am J Reprod Immunol 46:161-8. 2001
  10. doi request reprint Bax-associated mechanisms underlying the response of embryonic cells to methotrexate
    S Savion
    Department of Cell and Developmental Biology, Sackler School of Medicine, Tel Aviv University, Ramat Aviv, Tel Aviv 69978, Israel
    Toxicol In Vitro 23:1062-8. 2009

Collaborators

Detail Information

Publications26

  1. pmc NF-kappa B DNA-binding activity in embryos responding to a teratogen, cyclophosphamide
    Arkady Torchinsky
    Department of Embryology and Teratology, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
    BMC Dev Biol 2:2. 2002
    ....
  2. pmc Teratogen-induced alterations in microRNA-34, microRNA-125b and microRNA-155 expression: correlation with embryonic p53 genotype and limb phenotype
    Keren Gueta
    Department of Cell and Developmental Biology, Sackler School of Medicine, Tel Aviv University, Ramat Aviv, Tel Aviv, 69978, Israel
    BMC Dev Biol 10:20. 2010
    ..We evaluated how CP-induced alterations in the expression of these miRNAs in the embryonic limbs correlate with embryonic p53 genotype and CP-induced limb phenotypes...
  3. ncbi request reprint The role of pro- and anti-apoptotic molecular interactions in embryonic maldevelopment
    V Toder
    Department of Embryology and Teratology, Sackler School of Medicine, Tel Aviv University, Ramat Aviv, Tel Aviv, Israel
    Am J Reprod Immunol 48:235-44. 2002
    ..This review summarizes the functioning of pro- and anti-apoptotic molecules in embryos responding to various teratogens. The effect of potentiation of the maternal immune system on these molecules is also discussed...
  4. pmc TNF-alpha in pregnancy loss and embryo maldevelopment: a mediator of detrimental stimuli or a protector of the fetoplacental unit?
    V Toder
    Department of Embryology and Teratology, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
    J Assist Reprod Genet 20:73-81. 2003
    ..This review summarizes and conceptualizes the studies addressing TNF-alpha-activated intracellular signaling and the possible functional role of TNF-alpha in embryonic development...
  5. ncbi request reprint Apoptosis in the uterus of mice with pregnancy loss
    S Savion
    Department of Embryology and Teratology, Sackler School of Medicine, Tel Aviv University, Ramat Aviv, Tel Aviv, Israel
    Am J Reprod Immunol 47:118-27. 2002
    ....
  6. ncbi request reprint A possible role for granulocyte macrophage-colony stimulating factor in modulating teratogen-induced effects
    S Savion
    Department of Embryology and Teratology, Sackler School of Medicine, Tel Aviv University, Ramat Aviv, Israel
    Teratog Carcinog Mutagen 19:171-82. 1999
    ..Our results suggest a possible role for GM-CSF in modulating teratogen-induced effects, a process in which maternal immune responses such as splenocytes proliferation and cytokine production might be involved...
  7. ncbi request reprint Diabetes teratogenicity is accompanied by alterations in macrophages and T cell subpopulations in the uterus and lymphoid organs
    S Savion
    Department of Cell and Developmental Biology, Sackler School of Medicine, Tel Aviv University, Ramat Aviv, Tel Aviv 69978, Israel
    Int Immunopharmacol 4:1319-27. 2004
    ....
  8. ncbi request reprint TGFbeta2 in embryos with inborn anomalies: effect of maternal immunopotentiation
    I Ivnitsky
    Department of Embryology and Teratology Sackler School of Medicine, Tel Aviv University, Israel
    Am J Reprod Immunol 45:41-51. 2001
    ....
  9. ncbi request reprint Expression of tumor necrosis factor-alpha in the pregnant uterus of diabetic mice: effect of maternal immunopotentiation
    A Flein
    Department of Embryology and Teratology, Sackler School of Medicine, Tel Aviv University, Ramat Aviv, Israel
    Am J Reprod Immunol 46:161-8. 2001
    ..We intend to characterize their pattern and to evaluate whether the potentiation of the maternal immune system alters the pattern of the expression of the cytokine...
  10. doi request reprint Bax-associated mechanisms underlying the response of embryonic cells to methotrexate
    S Savion
    Department of Cell and Developmental Biology, Sackler School of Medicine, Tel Aviv University, Ramat Aviv, Tel Aviv 69978, Israel
    Toxicol In Vitro 23:1062-8. 2009
    ..Altogether, the differential sensitivity of WT or Bax(-/-) MEFs to MTX suggests a possible involvement of this molecule in the response of embryonic cells to teratogens...
  11. ncbi request reprint Cytokine expression in the uterus of mice with pregnancy loss: effect of maternal immunopotentiation with GM-CSF
    S Savion
    Department of Embryology and Teratology, Sackler School of Medicine, Tel Aviv University, Ramat Aviv, Tel Aviv 69978, Israel
    Reproduction 123:399-409. 2002
    ..These results indicate a possible role for maternal immunopotentiation with GM-CSF in the mechanisms mediating the early stages of pregnancy loss, possibly via modulation of TNF-alpha and TGF-beta2 activity...
  12. ncbi request reprint Cellular events and the pattern of p53 protein expression following cyclophosphamide-initiated cell death in various organs of developing embryo
    A Torchinsky
    Department of Embryology and Teratology, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
    Teratog Carcinog Mutagen 19:353-67. 1999
    ..They also suggest that the input of p53 in determining the response of these organ systems to CP-induced teratogenic insult may be different. Teratogenesis Carcinog. Mutagen. 19:353-367, 1999...
  13. ncbi request reprint TNF-alpha acts to prevent occurrence of malformed fetuses in diabetic mice
    A Torchinsky
    Department of Embryology and Teratology, Sackler School of Medicine, Tel Aviv University, Ramat Aviv, Tel Aviv 69978, Israel
    Diabetologia 47:132-9. 2004
    ..To investigate how TNF-alpha regulates the response of embryos to diabetes-induced embryopathic stress, we used streptozotocin-induced diabetic TNF-alpha knockout mice...
  14. ncbi request reprint Immunopotentiation and pregnancy loss
    V Toder
    Department of Embryology and Teratology, Tel Aviv University Medical School, Israel
    J Reprod Fertil Suppl 37:79-84. 1989
    ..The exact mechanism of this improvement is still unclear but it seems that systemic cellular mechanisms are not responsible for the effect...
  15. ncbi request reprint Increased TNF-alpha expression in cultured mouse embryos exposed to teratogenic concentrations of glucose
    A Torchinsky
    Department of Embryology and Teratology, Sackler School of Medicine, Tel Aviv University, Israel
    Reproduction 125:527-34. 2003
    ..Together, these findings indicate that TNF-alpha produced by the embryo may be involved in regulating the response of embryos to diabetes-generated embryopathic stress...
  16. doi request reprint NF-κB-associated mechanisms underlying the response of embryonic cells to Doxorubicin
    S Savion
    Department of Cell and Developmental Biology, Sackler School of Medicine, Tel Aviv University, Ramat Aviv, Tel Aviv 69978, Israel
    Toxicol In Vitro 27:804-11. 2013
    ..The fact that the response of the cells to the teratogen was clearly p65-dependent implicates this molecule to be involved in the response of the embryonic cells to DOX...
  17. ncbi request reprint TNF-alpha messenger RNA and protein expression in the uteroplacental unit of mice with pregnancy loss
    M Gorivodsky
    Department of Embryology and Teratology, Sackler School of Medicine, Tel Aviv University, Ramat Aviv, Israel
    J Immunol 160:4280-8. 1998
    ..These data clearly suggest an involvement of TNF-alpha in pathways leading to both spontaneous and induced placental death...
  18. ncbi request reprint Diabetes teratogenicity in mice is accompanied with distorted expression of TGF-beta2 in the uterus
    A Fein
    Department of Embryology and Teratology, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
    Teratog Carcinog Mutagen 22:59-71. 2002
    ..Immunopotentiation that was shown to improve the reproductive performance of the diabetic mice was accompanied by a partial normalization of TGF-beta2 expression in embryonic vicinity...
  19. ncbi request reprint Immunoteratology: I. MHC involvement in the embryo response to teratogens in mice
    A Torchinsky
    Department of Embryology and Teratology, Sackler School of Medicine, Tel Aviv University, Israel
    Am J Reprod Immunol 34:288-98. 1995
    ..The present study was carried out to evaluate an involvement of MHC-associated maternal immunoreactivity in response to environmental teratogens...
  20. ncbi request reprint Nonspecific immunopotentiators and pregnancy loss: complete Freund adjuvant reverses high fetal resorption rate in CBA x DBA/2 mouse combination
    V Toder
    Department of Embryology and Teratology, Sackler School of Medicine, Tel Aviv University, Israel
    Am J Reprod Immunol 24:63-6. 1990
    ..Possible mechanisms of this fetal protection are discussed...
  21. ncbi request reprint NF-kappaB regulates the response of embryonic cells to heat shock
    S Savion
    Department of Cell and Developmental Biology, Sackler School of Medicine, Tel Aviv University, Ramat Aviv, Israel
    Int J Hyperthermia 23:277-86. 2007
    ..However, it was again found to be more prominent in p65-/- MEFs. Taken together, our results suggest a protective role for the p65 subunit of NF-kappaB in mechanisms underlying the response of embryonic cells to heat shock...
  22. ncbi request reprint Hormones, cytokines and fetal anomalies in habitual abortion
    H Carp
    Department of Obstetrics and Gynecology, Sheba Medical Center, Tel Aviv, Israel
    Gynecol Endocrinol 15:472-83. 2001
    ..This review assesses fetal structural anomalies in humans and laboratory animals as causes of pregnancy loss, the role of cytokines in those anomalies and the role of immunomodulation and hormones in modifying these effects...
  23. ncbi request reprint TNF-alpha-mediated stress-induced early pregnancy loss: a possible role of leukemia inhibitory factor
    A Torchinsky
    Department of Cell and Developmental Biology, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
    Chem Immunol Allergy 89:62-71. 2005
    ..In this brief review, we discuss this possibility based on these studies as well as on those addressing TNF-alpha and LIF signaling...
  24. ncbi request reprint TNF-alpha expression in embryos exposed to a teratogen
    I Ivnitsky
    Department of Embryology and Teratology, Sackler School of Medicine, Tel Aviv University, Israel
    Am J Reprod Immunol 40:431-40. 1998
    ..The effect of maternal immunostimulation increasing the embryo's tolerance to CP on TNF-alpha expression was also investigated...
  25. ncbi request reprint To die or not to die: the function of the transcription factor NF-kappaB in embryos exposed to stress
    A Torchinsky
    Department of Cell and Developmental Biology, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
    Am J Reprod Immunol 51:138-43. 2004
    ....
  26. ncbi request reprint Immune reproductive failure: effect of nonspecific immunostimulation in mouse model
    D Strassburger
    Department of Embryology and Teratology, Sackler School of Medicine, Tel Aviv University, Ramat Aviv, Israel
    Am J Reprod Immunol 28:274-6. 1992
    ..Information obtained from nonspecific immunopotentiation in the CBA/J-DBA/2J model may contribute the assessment of nonspecific immunotherapy in humans...