Y Shoenfeld

Summary

Affiliation: Tel Aviv University
Country: Israel

Publications

  1. ncbi request reprint Overlapping humoral autoimmunity links rheumatic fever and the antiphospholipid syndrome
    M Blank
    Research Center for Autoimmune Diseases, Sheba Medical Center, Tel Hashomer 52621, Israel
    Rheumatology (Oxford) 45:833-41. 2006
  2. doi request reprint The future of autoimmunity
    Yehuda Shoenfeld
    The Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel Hashomer, Israel
    Clin Rev Allergy Immunol 42:113-20. 2012
  3. doi request reprint Open questions in autoimmunity: discussions from the 2013 Controversies in Rheumatology and Autoimmunity Meeting
    Carlo Selmi
    Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel Hashomer 52621, Israel Incumbent of the Laura Schwarz kipp Chair for Research of Autoimmune Diseases, Sackler Faculty of Medicine, Tel Aviv University, Israel
    BMC Med 12:50. 2014
  4. pmc Erdheim-Chester Disease: a comprehensive review of the literature
    Roei D Mazor
    The Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel Hashomer, Israel
    Orphanet J Rare Dis 8:137. 2013
  5. doi request reprint Everything is autoimmune until proven otherwise
    Yehuda Shoenfeld
    Incumbent of the Laura Schwarz Kipp Chair for Research of Autoimmune Diseases, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    Clin Rev Allergy Immunol 45:149-51. 2013
  6. ncbi request reprint Autoimmune (auto-inflammatory) syndrome induced by adjuvants (ASIA)--animal models as a proof of concept
    Paola Cruz-Tapias
    Head of Zabludowitz Center for Autoimmune Diseases, Sheba Medical Center, Tel Hashomer 52621, Israel
    Curr Med Chem 20:4030-6. 2013
  7. pmc Novel aspects of Sjögren's syndrome in 2012
    Angela Tincani
    Rheumatology and Clinical Immunology Unit, Spedali Civili, Piazzale Spedali Civili 1, 25100 Brescia, Italy
    BMC Med 11:93. 2013
  8. pmc Biologic therapy for autoimmune diseases: an update
    Ziv Rosman
    Department of Medicine C, Wolfson Medical Center, 61 Halochamim Street, POB 63, Holon, 58100 Israel
    BMC Med 11:88. 2013
  9. pmc The thrombophilic network of autoantibodies in celiac disease
    Aaron Lerner
    Pediatric Gastroenterology and Nutrition Unit, Carmel Medical Center, B, Rappaport School of Medicine, Technion Israel Institute of Technology, Michal St, No 7, Haifa, 34362, Israel
    BMC Med 11:89. 2013
  10. pmc Coagulopathy triggered autoimmunity: experimental antiphospholipid syndrome in factor V Leiden mice
    Aviva Katzav
    Department of Neurology and Sagol Center for Neurosciences, Sheba Medical Center, Tel Hashomer, 2 Sheba Rd, Ramat Gan 52621, Israel
    BMC Med 11:92. 2013

Collaborators

Detail Information

Publications163 found, 100 shown here

  1. ncbi request reprint Overlapping humoral autoimmunity links rheumatic fever and the antiphospholipid syndrome
    M Blank
    Research Center for Autoimmune Diseases, Sheba Medical Center, Tel Hashomer 52621, Israel
    Rheumatology (Oxford) 45:833-41. 2006
    ..We assessed the presence of shared epitopes between M protein, N-acetyl-beta-D-glucosamine (GlcNAc) and beta2 glycoprotein-I (beta2GPI), the pathogenic molecules engaged in these autoimmune conditions...
  2. doi request reprint The future of autoimmunity
    Yehuda Shoenfeld
    The Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel Hashomer, Israel
    Clin Rev Allergy Immunol 42:113-20. 2012
    ..The goal is to bring to the readership provocative articles that ultimately will lead to improvement in patient care...
  3. doi request reprint Open questions in autoimmunity: discussions from the 2013 Controversies in Rheumatology and Autoimmunity Meeting
    Carlo Selmi
    Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel Hashomer 52621, Israel Incumbent of the Laura Schwarz kipp Chair for Research of Autoimmune Diseases, Sackler Faculty of Medicine, Tel Aviv University, Israel
    BMC Med 12:50. 2014
    ..In summary, we will herein present these topics of discussion and underline the conclusions obtained by rheumatologists during the 2013 CORA Meeting. ..
  4. pmc Erdheim-Chester Disease: a comprehensive review of the literature
    Roei D Mazor
    The Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel Hashomer, Israel
    Orphanet J Rare Dis 8:137. 2013
    ..This work highlights the different clinical, radiological and pathological manifestations associated with ECD, the differential diagnoses, the various treatment options and the acknowledged science explaining the disease. ..
  5. doi request reprint Everything is autoimmune until proven otherwise
    Yehuda Shoenfeld
    Incumbent of the Laura Schwarz Kipp Chair for Research of Autoimmune Diseases, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    Clin Rev Allergy Immunol 45:149-51. 2013
    ....
  6. ncbi request reprint Autoimmune (auto-inflammatory) syndrome induced by adjuvants (ASIA)--animal models as a proof of concept
    Paola Cruz-Tapias
    Head of Zabludowitz Center for Autoimmune Diseases, Sheba Medical Center, Tel Hashomer 52621, Israel
    Curr Med Chem 20:4030-6. 2013
    ..All these models support the concept of ASIA, as the Autoimmune (Auto-inflammatory) Syndrome Induced by Adjuvants. ..
  7. pmc Novel aspects of Sjögren's syndrome in 2012
    Angela Tincani
    Rheumatology and Clinical Immunology Unit, Spedali Civili, Piazzale Spedali Civili 1, 25100 Brescia, Italy
    BMC Med 11:93. 2013
    ..Vitamin D supplementation may be an additional tool for optimization of SS treatment...
  8. pmc Biologic therapy for autoimmune diseases: an update
    Ziv Rosman
    Department of Medicine C, Wolfson Medical Center, 61 Halochamim Street, POB 63, Holon, 58100 Israel
    BMC Med 11:88. 2013
    ....
  9. pmc The thrombophilic network of autoantibodies in celiac disease
    Aaron Lerner
    Pediatric Gastroenterology and Nutrition Unit, Carmel Medical Center, B, Rappaport School of Medicine, Technion Israel Institute of Technology, Michal St, No 7, Haifa, 34362, Israel
    BMC Med 11:89. 2013
    ..However, the well known thrombogenic factors, antiphosphatidylserine/prothrombin and antiprothrombin have never been explored in celiac disease...
  10. pmc Coagulopathy triggered autoimmunity: experimental antiphospholipid syndrome in factor V Leiden mice
    Aviva Katzav
    Department of Neurology and Sagol Center for Neurosciences, Sheba Medical Center, Tel Hashomer, 2 Sheba Rd, Ramat Gan 52621, Israel
    BMC Med 11:92. 2013
    ..We investigated interactions between genetically and autoimmune-mediated coagulopathies by inducing experimental antiphospholipid syndrome (eAPS) in mice carrying the factor V Leiden (FVL) mutation...
  11. pmc 16/6-idiotype expressing antibodies induce brain inflammation and cognitive impairment in mice: the mosaic of central nervous system involvement in lupus
    Shaye Kivity
    The Zabludovicz Center for Autoimmune Diseases, Sheba Medical Center, Tel Hashomer, 2 Derech Sheba St, Ramat Gan, 52621, Israel
    BMC Med 11:90. 2013
    ..We assessed behavior and brain pathology of naive mice injected intra-cerebra-ventricularly (ICV) with the 16/6-Id antibody...
  12. pmc The hyperferritinemic syndrome: macrophage activation syndrome, Still's disease, septic shock and catastrophic antiphospholipid syndrome
    Cristina Rosario
    Center for Autoimmune Diseases, Sheba Medical Center affiliated with the Tel Aviv University, Tel Hashomer 52621, Israel
    BMC Med 11:185. 2013
    ..Hyperferritinemia is associated with a multitude of clinical conditions and with worse prognosis in critically ill patients...
  13. pmc Video Q&A: what is ASIA? An interview with Yehuda Shoenfeld
    Yehuda Shoenfeld
    Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel Aviv University, Tel Hashomer 52621, Israel
    BMC Med 11:118. 2013
    ..In this Q&A, we talk to Professor Yehuda Shoenfeld about Autoimmune Syndrome Induced by Adjuvants (ASIA) and discuss his recommendations regarding further research in the field...
  14. pmc Novel pebbles in the mosaic of autoimmunity
    Carlo Perricone
    The Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel Hashomer 52621, Israel
    BMC Med 11:101. 2013
    ..This is the new wind blowing within the branches of autoimmunity, adding knowledge to physicians for helping patients with autoimmune disease...
  15. pmc Neurological dysfunction associated with antiphospholipid syndrome: histopathological brain findings of thrombotic changes in a mouse model
    Lea Ziporen
    Research Unit of Autoimmune Diseases, Department of Medicine B, Sheba Medical Center, Tel Hashomer 52621, Israel
    Clin Dev Immunol 11:67-75. 2004
    ..Thrombotic occlusion of capillaries in combination with mild inflammation was the main finding and may underlie the neurological defects displayed by mice with APS...
  16. pmc Autoantibodies profile in the sera of patients with Sjogren's syndrome: the ANA evaluation--a homogeneous, multiplexed system
    Boris Gilburd
    Department of Medicine B, Center for Autoimmune Diseases, Sheba Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Hashomer, Israel
    Clin Dev Immunol 11:53-6. 2004
    ..It offers a rapid and sensitive method to assess multiple analyses in a single tube/well...
  17. ncbi request reprint Prevalence and clinical correlations of antibodies against six beta2-glycoprotein-I-related peptides in the antiphospholipid syndrome
    Y Shoenfeld
    Department of Medicine B, Sheba Medical Center, Tel Hashomer, Israel
    J Clin Immunol 23:377-83. 2003
    ..Evaluation of APS patients for the presence of specific antipeptides Abs may be of a value in predicting the risk for future thrombotic and obstetrical complication, as well as for specific therapeutic purposes...
  18. ncbi request reprint Accelerated atherosclerosis in autoimmune rheumatic diseases
    Yehuda Shoenfeld
    Department of Medicine B, Center for Autoimmune Diseases, Sheba Medical Center Tel Hashomer, Sackler Faculty of Medicine, Tel Aviv University, Israel
    Circulation 112:3337-47. 2005
  19. ncbi request reprint Systemic antiphospholipid syndrome
    Y Shoenfeld
    Center for Autoimmune Diseases, Department of Medicine B, Sheba Medical Center, Tel Hashomer, Sackler Faculty of Medicine, Tel Aviv University, Israel
    Lupus 12:497-8. 2003
    ..In the article it is suggested to add to the syndrome the word systemic in analogy to its sister condition, systemic lupus erythematosus...
  20. ncbi request reprint The diversity of autoantibodies to P-ribosomal: the infectious-autoimmunity plot
    Yehuda Shoenfeld
    Department of Internal Medicine B and Center for Autoimmune Diseases, Sheba Medical Center, Tel Hashomer, Tel Aviv University, Tel Aviv, Israel
    J Mol Med (Berl) 85:907-9. 2007
  21. ncbi request reprint Autoantibodies and prediction of reproductive failure
    Yehuda Shoenfeld
    Department of Internal Medicine B, Sheba Medical Center, Tel Hashomer, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    Am J Reprod Immunol 56:337-44. 2006
    ..To determine which autoantibodies are associated with reproductive failure...
  22. ncbi request reprint EASI - The European Autoimmunity Standardisation Initiative: a new initiative that can contribute to agreed diagnostic models of diagnosing autoimmune disorders throughout Europe
    Yehuda Shoenfeld
    Department of Medicine B and Center for Autoimmune Diseases, Sheba Medical Center Affiliated to Tel Aviv University, Tel Hashomer 52621, Israel
    Ann N Y Acad Sci 1109:138-44. 2007
    ..All EASI teams will present and discuss the results of their activities with other experts in the field in an EASI Conference, which will be held biannually at the International Congress on Autoimmunity...
  23. ncbi request reprint Autoantibodies associated with reproductive failure
    Y Shoenfeld
    Internal Medicine B and The Center for Autoimmune Diseases, Sheba Medical Center, Tel Hashomer, Sackler Faculty of Medicine, Tel Aviv University, Israel
    Lupus 13:643-8. 2004
    ....
  24. ncbi request reprint To smell autoimmunity: anti-P-ribosomal autoantibodies, depression, and the olfactory system
    Yehuda Shoenfeld
    Department of Medicine B, Center for Autoimmune Diseases, Chaim Sheba Medical Center, 52621 Tel Hashomer, Israel
    J Autoimmun 28:165-9. 2007
    ..The titer of the autoantibodies correlate with disease activity, kidney involvement and hepatitis. In this review, the mechanisms involved in CNS involvement and its relationship with anti-P ribosomal antibodies will be described...
  25. ncbi request reprint The infectious etiology of the antiphospholipid syndrome (APS)
    Y Shoenfeld
    Department of Medicine B, Center for Autoimmune Diseases, Sheba Medical Center, Tel Hashomer, and Sackler Faculty of Medicine, Tel Aviv University, Israel
    Autoimmun Rev 3:S32-4. 2004
  26. ncbi request reprint Anti-DNA idiotypes: from induction of disease to novel therapeutical approaches
    Yehuda Shoenfeld
    Department of Medicine B, and Center for Autoimmune Diseases, Sheba Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Israel
    Immunol Lett 100:73-7. 2005
  27. ncbi request reprint Anti-phospholipid syndrome from a systemic disease toward the infectious etiology
    Y Shoenfeld
    Department of Medicine B, Center for Autoimmune Diseases, Sheba Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Hashomer 52621, Israel
    Rev Med Interne 25:S10-1. 2004
  28. ncbi request reprint i.v.IG for autoimmune, fibrosis, and malignant conditions: our experience with 200 patients
    Yehuda Shoenfeld
    Center for Autoimmune Diseases, Sheba Medical Center, Tel Hashomer, and Sackler Faculty of Medicine, Tel Aviv University, Israel
    J Clin Immunol 24:107-14. 2004
    ..When given properly (not more than 0.4 g/Kg. B.W. 5 day), side effects are minimal. Yet, its high price (> 3000 US dollars per monthly course) precludes the application of i.v.IG more frequently...
  29. ncbi request reprint IVIg therapy in autoimmunity and related disorders: our experience with a large cohort of patients
    Yehuda Shoenfeld
    Center for Autoimmune Diseases, Department of Internal Medicine B, Sheba Medical Center, Tel Hashomer, Ramat Gan 52621, Israel
    Autoimmunity 38:123-37. 2005
    ..We suggest that in the presence of a steroid and immunosuppressive-resistant autoimmune disease, IVIg is a rational and safe choice...
  30. ncbi request reprint Autoantibodies-the smoke and the fire
    Yehuda Shoenfeld
    Department of Medicine B and Center for Autoimmune Diseases Sheba Medical Center, Sackler Faculty of Medicine, Incumbent of the Laura Schwarz Kipp Chair for Research of Autoimmune Diseases, Tel Aviv University Tel Hashomer Israel
    Autoimmunity 38:1-2. 2005
  31. pmc A novel system to diagnose cutaneous adverse drug reactions employing the cellscan--comparison with histamine releasing test and Inf-gamma Releasing Test
    Ilan Goldberg
    Department of Dermatology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
    Clin Dev Immunol 12:85-90. 2005
    ..There are several mechanisms to describe allergic drug reactions yet the methods to diagnose them are limited...
  32. ncbi request reprint 5th International symposium on IVIG: IVIG in the third millenium, 25-27 September 2003, Interlaken, Switzerland
    Yehuda Shoenfeld
    Department of Medicine B and Center for Autoimmune Diseases, Sheba Medical Center, Affiliated to Sackler Faculty of Medicine, Tel Aviv University, Tel Hashomer, Israel
    Autoimmun Rev 3:234-41. 2004
  33. ncbi request reprint Eighth international workshop on autoantibodies and autoimmunity Berlin, Germany, 10-13 September, 2003
    Y Shoenfeld
    Center for Autoimmune Diseases, Department of Medicine B, Sheba Medical Center, Tel Hashomer, Tel Aviv University, Tel Hashomer, Israel
    Autoimmun Rev 3:77-84. 2004
  34. ncbi request reprint [Patients' families abuse the medical and nursing staff]
    Y Shoenfeld
    Department of Medicine B, Sheba Medical Center, Tel Hashomer, Israel
    Harefuah 144:74-5. 2005
  35. ncbi request reprint Autoantibodies against protective molecules--C1q, C-reactive protein, serum amyloid P, mannose-binding lectin, and apolipoprotein A1: prevalence in systemic lupus erythematosus
    Yehuda Shoenfeld
    Center for Autoimmune Diseases and Department of Medicine B, Chaim Sheba Medical Center, Tel Hashomer, Israel
    Ann N Y Acad Sci 1108:227-39. 2007
    ..These autoantibodies may play a pathogenic role in the development or perpetuation of autoimmunity in SLE...
  36. ncbi request reprint APS--more systemic disease than SLE
    Yehuda Shoenfeld
    Department of Medicine B and Center for Autoimmune Diseases, Sheba Medical Center, Tel Hashomer, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    Clin Rev Allergy Immunol 32:129-30. 2007
    ..Importantly, there is a wide range of clinical presentations. In this issue we have attempted to provide an overview of these features and place it in the context of autoimmunity...
  37. doi request reprint Autoantibody explosion in antiphospholipid syndrome
    Yehuda Shoenfeld
    Department of Medicine B, Sheba Medical Center, Tel Hashomer, Tel Aviv University, Israel
    J Autoimmun 30:74-83. 2008
    ..This autoantibody explosion might be important in early identification of the syndrome and its manifestations...
  38. doi request reprint 'ASIA' - autoimmune/inflammatory syndrome induced by adjuvants
    Yehuda Shoenfeld
    The Zabludowicz Center for Autoimmune Diseases, Department of Medicine B Sheba Medical Center, Tel Hashomer, Israel
    J Autoimmun 36:4-8. 2011
    ..Relating to the current knowledge we would like to suggest to include these comparable conditions under a common syndrome entitled ASIA, "Autoimmune (Auto-inflammatory) Syndrome Induced by Adjuvants"...
  39. pmc Atherosclerosis
    Y Sherer
    Department of Medicine B and Centre of Autoimmune Diseases, Sheba Medical Centre, Tel Hashomer, 52621 Israel
    Ann Rheum Dis 61:97-9. 2002
    ..Is atherosclerosis a cellular or humoral mediated autoimmune disease?..
  40. ncbi request reprint The mosaic of autoimmunity: genetic factors involved in autoimmune diseases--2008
    Yehuda Shoenfeld
    Department of Medicine B and Center for Autoimmune Diseases, Sheba Medical Center, Tel Hashomer, Israel
    Isr Med Assoc J 10:3-7. 2008
  41. doi request reprint Tolerogenic dendritic cells inhibit antiphospholipid syndrome derived effector/memory CD4⁺ T cell response to β2GPI
    Honorio Torres-Aguilar
    Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    Ann Rheum Dis 71:120-8. 2012
    ..We aim to evaluate the capability of tDCs to induce antigen-specific tolerance in effector/memory T cells from patients with APS and to elucidate the involved mechanism...
  42. ncbi request reprint Neuronal-binding antibodies from patients with antiphospholipid syndrome induce cognitive deficits following intrathecal passive transfer
    Y Shoenfeld
    Department of Medicine B and Research Center for Autoimmune Diseases, Sheba MedicalCenter, Tel Hashomer, Israel
    Lupus 12:436-42. 2003
    ..These results support the hypothesis that aPL that gain access to the central nervous system may play a direct role in the pathogenesis of neurological manifestations of APS...
  43. ncbi request reprint Induction and treatment of the antiphospholipid syndrome--lessons from animal models
    Y Shoenfeld
    Department of Medicine B and Center of Autoimmune Diseases, Sheba Medical Center, Tel Hashomer, Israel
    Eur J Clin Invest 31:736-40. 2001
    ..Experimental induction and treatment of APS largely contributes to our understanding of the disease and to better management of its clinical characteristics...
  44. ncbi request reprint Bcg and autoimmunity: another two-edged sword
    Y Shoenfeld
    Department of Internal Medicine B and C and the Research Center for Autoimmune Diseases, Sheba Medical Center, Tel Hashomer, Israel
    J Autoimmun 16:235-40. 2001
    ..One of these patients developed Reiter's syndrome. We also refer to the possible immune mechanisms by which BCG can trigger arthritis, as well as to the link between mycobacterial infection, BCG immunotherapy and autoimmunity...
  45. ncbi request reprint Autoantibodies associated with atherosclerosis
    Y Shoenfeld
    Department of Medicine B and The Center for Autoimmune Diseases, Sheba Medical Center, Tel Hashomer, Israel
    Ann Med 32:37-40. 2000
    ..This manuscript provides a review of autoantibodies directed towards oxidized low-density lipoprotein (oxLDL), cardiolipin, beta2-glycoprotein-I and heat-shock protein 60/65, and their association with human and murine atherosclerosis...
  46. ncbi request reprint Heat shock protein 60/65, beta 2-glycoprotein I and oxidized LDL as players in murine atherosclerosis
    Y Shoenfeld
    Department of Medicine B, Sheba Medical Center, Tel Hashomer, Israel
    J Autoimmun 15:199-202. 2000
    ..Thus, autoimmune factors appear to influence early artherosclerosis progression in mice. If proven in humans these antigen specific responses may be harnessed for selective immunomodulation of the atherosclerotic plaque...
  47. ncbi request reprint The expanding world of autoimmunity
    Yehuda Shoenfeld
    Dept of Medicine B and Center of Autoimmune Diseases, Sheba Medical Center, 52621, Tel Hashomer, Israel
    Trends Immunol 23:278-9. 2002
  48. ncbi request reprint Classification of anti-endothelial cell antibodies into antibodies against microvascular and macrovascular endothelial cells: the pathogenic and diagnostic implications
    Yehuda Shoenfeld
    Department of Medicine B, Center for Autoimmune Diseases, Sackler Faculty of Medicine, Tel Aviv University, Israel
    Cleve Clin J Med 69:SII65-7. 2002
  49. ncbi request reprint The mosaic of autoimmunity: prediction, autoantibodies, and therapy in autoimmune diseases--2008
    Yehuda Shoenfeld
    Department of Medicine B and Center for Autoimmune Diseases, Sheba Medical Center, Tel Hashomer, Israel
    Isr Med Assoc J 10:13-9. 2008
  50. doi request reprint Whither autoimmunity: the lessons of anti-CCP and B cell depletion
    Yehuda Shoenfeld
    Department of Medicine B and Center for Autoimmune Diseases, Sheba Medical Center, Affiliated to Tel Aviv University, Tel Hashomer, 52621, Israel
    Clin Rev Allergy Immunol 34:1-3. 2008
    ..Although the Th1 to Th2 dichotomy is well known to both murine and human immunologists, it is really in the study of specific inflammatory responses that they are correctly placed in the perspective of the continuum of immunopathology...
  51. ncbi request reprint [Doctors as naive (innocent) drug advertisers]
    Y Shoenfeld
    Harefuah 147:98-9. 2008
  52. doi request reprint The autoimmunologist: geoepidemiology, a new center of gravity, and prime time for autoimmunity
    Yehuda Shoenfeld
    Department of Medicine B, Center for Autoimmune Diseases, Sheba Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    J Autoimmun 31:325-30. 2008
    ....
  53. doi request reprint Antiphospholipid syndrome and systemic lupus erythematosus: are they separate entities or just clinical presentations on the same scale?
    Yehuda Shoenfeld
    Department of Internal Medicine B and Center for Autoimmune Diseases, Sheba Medical Center, Tel Aviv University, Israel
    Curr Opin Rheumatol 21:495-500. 2009
    ..However, cases of primary antiphospholipid syndrome were reported to evolve into systemic lupus erythematosus over time suggesting that these apparently different diseases are somehow related...
  54. doi request reprint Geoepidemiology of autoimmune rheumatic diseases
    Yinon Shapira
    Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel Hashomer 52621, Israel
    Nat Rev Rheumatol 6:468-76. 2010
    ....
  55. ncbi request reprint The mosaic of autoimmunity: hormonal and environmental factors involved in autoimmune diseases--2008
    Yehuda Shoenfeld
    Department of Medicine B and Center for Autoimmune Diseases, Sheba Medical Center, Tel Hashomer, Israel
    Isr Med Assoc J 10:8-12. 2008
  56. ncbi request reprint Induction of early atherosclerosis in LDL-receptor-deficient mice immunized with beta2-glycoprotein I
    J George
    From the Research Unit of Autoimmune Diseases, Department of Medicine B, Sheba Medical Center, Tel Hashomer, Sackler Faculty of Medicine, Tel Aviv University, Israel
    Circulation 98:1108-15. 1998
    ..The present study was undertaken to evaluate the effect of beta2GPI immunization on the progression of atherosclerosis...
  57. ncbi request reprint Restricted specificity of anti-ribosomal P antibodies to SLE patients in Israel
    O Shovman
    Center for Autoimmune Diseases and Dept of Medicine B, Sheba Medical Center, Tel Hashomer, Israel
    Clin Exp Rheumatol 24:694-7. 2006
    ..The aim of our study was to evaluate the prevalence of aRib-P Ab and their correlation with clinical manifestations and anti-dsDNA antibodies in SLE patients from Israel...
  58. ncbi request reprint Coronary artery disease but not coronary calcification is associated with elevated levels of cardiolipin, beta-2-glycoprotein-I, and oxidized LDL antibodies
    Y Sherer
    Department of Medicine 'B' and Center of Autoimmune Diseases, Sheba Medical Center, Tel-Hashomer, Israel
    Cardiology 95:20-4. 2001
    ..046). CONCLUSION: Anti-CL, beta2GPI and oxLDL antibodies are elevated in coronary heart disease patients regardless of coronary calcification...
  59. pmc Anti-serum amyloid component P antibodies in patients with systemic lupus erythematosus correlate with disease activity
    G Zandman-Goddard
    Centre for Autoimmune Diseases and Department of Medicine B, Sheba Medical Centre, Tel Hashomer, Israel 52621
    Ann Rheum Dis 64:1698-702. 2005
    ....
  60. ncbi request reprint Hyperimmunization of apo-E-deficient mice with homologous malondialdehyde low-density lipoprotein suppresses early atherogenesis
    J George
    Department of Medicine B, Sheba Medical Center, Tel Hashomer, Israel
    Atherosclerosis 138:147-52. 1998
    ..The results of this study show that immunization with MDA-LDL has a protective effect in apo-E-deficient mice, and further suggests that this mouse model is suitable for studies of immunomodulation...
  61. ncbi request reprint Cross-reactive epitopes on beta2-glycoprotein-I and Saccharomyces cerevisiae in patients with the antiphospholipid syndrome
    I Krause
    Department of Medicine E, Rabin Medical Center Beilinson Campus, Tel Aviv University, Tel Aviv, Israel
    Ann N Y Acad Sci 1108:481-8. 2007
    ..In conclusion, a subpopulation of anti-beta2GPI is specific to the glycosylated site of the beta2GPI molecule that cross-reacts with PPM...
  62. ncbi request reprint Novel insights into associations of antibodies against cardiolipin and beta2-glycoprotein I with clinical features of antiphospholipid syndrome
    O Shovman
    Department of Medicine B and Center for Autoimmune Diseases, Chaim Sheba Medical Center, Tel Hashomer, 52621, Israel
    Clin Rev Allergy Immunol 32:145-52. 2007
    ..This manuscript reviews the current studies published recently in this field and discusses the relationship between the existence of aCL and anti-beta2GPI antibodies and the main and unusual manifestations of APS...
  63. ncbi request reprint Cellular and humoral immune responses to heat shock protein 65 are both involved in promoting fatty-streak formation in LDL-receptor deficient mice
    J George
    Department of Cardiology and the Cardiovascular Research Laboratory, Tel Aviv Medical Center, Tel Aviv, Israel
    J Am Coll Cardiol 38:900-5. 2001
    ..CONCLUSIONS: Antibodies and lymphocytes reactive to HSP65 promote fatty-streak formation in mice, providing direct evidence for the proatherogenic properties of cellular and humoral immunity to HSP65...
  64. ncbi request reprint Anti-endothelial cell antibodies (AECA) in systemic sclerosis--increased sensitivity using different endothelial cell substrates and association with other autoantibodies
    Y Renaudineau
    Research Unit of Autoimmune Diseases, Sheba Medical Center, Tel-Hashomer, Sackler Faculty of Medicine, Tel-Aviv University, Israel
    Autoimmunity 33:171-9. 2001
    ..CONCLUSIONS: Since false-negative AECA may result from lack of expression of various antigens on a specific EC, analysis of AECA in SSc patients requires using several EC types, including microvascular EC...
  65. ncbi request reprint Adoptive transfer of beta(2)-glycoprotein I-reactive lymphocytes enhances early atherosclerosis in LDL receptor-deficient mice
    J George
    Research Unit of Autoimmune Diseases, Sheba Medical Center, Tel Hashomer, Sackler Faculty of Medicine, Tel Aviv, Israel
    Circulation 102:1822-7. 2000
    ..In the present study, we tested the hypothesis that adoptive transfer of beta2GPI-reactive T cells can accelerate fatty streak formation in LDL-RD mice...
  66. ncbi request reprint The dual association between lymphoma and autoimmunity
    M Ehrenfeld
    Research Centre for Autoimmune Diseases, Sheba Medical Centre, Tel-Hashomer, Sackler Faculty of Medicine, Tel-Aviv University, Israel
    Blood Cells Mol Dis 27:750-6. 2001
    ..Descriptions of lymphocytic malignancies among other autoimmune rheumatic disease have been published. In some patients, the malignant disease is diagnosed months or years before the appearance of the rheumatic disease...
  67. doi request reprint Common infectious agents prevalence in antiphospholipid syndrome
    H Zinger
    Department of Medicine B and Center of Autoimmune Diseases, Sheba Medical Center, Tel Hashomer, Israel
    Lupus 18:1149-53. 2009
    ..e. toxoplasma and rubella, might either be related to the pathogenesis of antiphospholipid syndrome or alternatively to its manifestations...
  68. doi request reprint Vitamin D: an instrumental factor in the anti-phospholipid syndrome by inhibition of tissue factor expression
    N Agmon-Levin
    The Zabludowicz Center for Autoimmune Diseases and Department of Medicine B, Sheba Medical Center, Tel Hashomer, Israel
    Ann Rheum Dis 70:145-50. 2011
    ..Therefore, we studied serum vitamin D levels in a cohort of APS patients, as well as the effect of vitamin D in an in vitro model of APS-mediated thrombosis...
  69. ncbi request reprint Mechanisms of action of the anti-atherogenic effect of magnesium: lessons from a mouse model
    Y Sherer
    Department of Medicine B, and Institute of Lipid and Atherosclerosis Research, Sheba Medical Center, Tel-Hashomer, Israel
    Magnes Res 14:173-9. 2001
    ..Platelets coverage area on extracellular matrix was similar between groups. These results suggest that Mg might affect LDL oxidation, and thus atherogenesis...
  70. ncbi request reprint Antiphospholipid antibody levels in intravenous immunoglobulin (IVIg) preparations
    Y Sherer
    Department of Medicine 'B' and Center of Autoimmune Diseases, Sheba Medical Center, Tel-Hashomer, Israel
    Lupus 10:568-70. 2001
    ..The absence of abnormal elevated levels of any of these autoantibodies in five different IVIg preparations provides additional evidence for the safety of IVIg use in APS...
  71. doi request reprint Infectious antibodies in systemic lupus erythematosus patients
    Y Berkun
    Safra Children Hospital, Sheba Medical Center, Tel Hashomer, Israel
    Lupus 18:1129-35. 2009
    ..Our data suggest the importance of previous exposure to infectious agents in the induction and the prevention of SLE...
  72. pmc Antiphospholipid antibodies bind ATP: a putative mechanism for the pathogenesis of neuronal dysfunction
    J Chapman
    Department of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel Aviv University, Ramat Aviv 69978, Israel
    Clin Dev Immunol 12:175-80. 2005
    ..We conclude that aPL IgG bind ATP, probably through beta32-GPI. This binding could interfere with the normal extracellular function of ATP and similar neurotransmitters...
  73. pmc Treatment of MRL/lpr mice, a genetic autoimmune model, with the Ras inhibitor, farnesylthiosalicylate (FTS)
    A Katzav
    Department of Physiology, Sackler Faculty of Medicine, Tel Aviv University, Ramat Aviv, Israel
    Clin Exp Immunol 126:570-7. 2001
    ..These findings indicate that modulation of Ras activation has a significant impact on the MRL/lpr model and may represent a new therapeutic approach for the treatment of systemic autoimmune diseases such as SLE and APS...
  74. pmc The diagnostic utility of anti-cyclic citrullinated peptide antibodies, matrix metalloproteinase-3, rheumatoid factor, erythrocyte sedimentation rate, and C-reactive protein in patients with erosive and non-erosive rheumatoid arthritis
    O Shovman
    Center for Autoimmune Diseases, Department of Medicine B, Sheba Medical Center, Israel
    Clin Dev Immunol 12:197-202. 2005
    ....
  75. ncbi request reprint Anti-prothrombin antibodies cause thrombosis in a novel qualitative ex-vivo animal model
    S Haj-Yahia
    Center for Autoimmune Diseases, Department of Medicine B, Tel Aviv, Israel
    Lupus 12:364-9. 2003
    ..Active immunization with prothrombin or beta2GPI/prothrombin is associated with prothrombotic activity of blood in an ex-vivo model. This is the first direct evidence for thrombus induction by aPT...
  76. ncbi request reprint Behavioral and cognitive deficits occur only after prolonged exposure of mice to antiphospholipid antibodies
    S Shrot
    Department of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel Aviv University, Israel
    Lupus 11:736-43. 2002
    ..The mechanism involved in these CNS manifestations remains to be elucidated...
  77. ncbi request reprint Hyperactivity in a mouse model of the antiphospholipid syndrome
    A Katzav
    Department of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel Aviv, Israel
    Lupus 10:496-9. 2001
    ..023) and higher number of stairs climbed (P < 0.019) by the mice in 3 min. This simple test demonstrated that experimental APS animals are significantly hyperactive and may serve as a marker for CNS involvement in this model...
  78. doi request reprint Molecular mimicry in systemic lupus erythematosus
    N Agmon-Levin
    Department of Medicine B, and The Center for Autoimmune Diseases Sheba Medical Center, Tel Hashomer, Israel
    Lupus 18:1181-5. 2009
    ..Here we review the current evidence of molecular mimicry between different infectious agents and systemic lupus erythematosus...
  79. ncbi request reprint Vaccination and autoimmunity-'vaccinosis': a dangerous liaison?
    Y Shoenfeld
    Department of Internal Medicine B, Sheba Medical Center, Tel Hashomer, Israel
    J Autoimmun 14:1-10. 2000
    ..We discuss the pros and cons of this issue (although the temporal relationship (i.e. always 2-3 months following immunization) is impressive)...
  80. ncbi request reprint Libman-Sacks endocarditis associated with antiphospholipid syndrome and infection
    M Blank
    Department of Medicine B, The Center for Autoimmune Diseases, Sheba Medical Center, Tel Hashomer 52621, Israel
    Thromb Res 114:589-92. 2004
    ..The involvement of complement C3c in the pathogenesis was documented. We assessed the beta2GPI-related target epitope recognized by the anti-beta2GPI Abs on the valves...
  81. ncbi request reprint The mosaic of autoimmunity
    C M Brickman
    Department of Medicine B and The Center for Autoimmune Diseases, The Chaim Sheba Medical Center, Tel Hashomer, Tel Aviv, Israel
    Scand J Clin Lab Invest Suppl 235:3-15. 2001
    ..Concluding remarks address the factors that normally prevent the progression of autoimmunity to autoimmune disease and the application of current knowledge to future therapeutic approaches...
  82. ncbi request reprint The association of thrombocytopenia with systemic manifestations in the antiphospholipid syndrome
    Ilan Krause
    Research Center for Autoimmune Diseases, Sheba Medical Center, Tel Hashomer 52621, Israel
    Immunobiology 210:749-54. 2005
    ..Our data suggest the presence of thrombocytopenia may be a risk factor for cardiac, neurological, articular and cutaneous complications in APS...
  83. ncbi request reprint Induction of oral tolerance in experimental antiphospholipid syndrome by feeding with polyclonal immunoglobulins
    Ilan Krause
    Center for Autoimmune Diseases, Sheba Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    Eur J Immunol 32:3414-24. 2002
    ..Our results point to a possible application of IVIG in the induction of oral tolerance against various autoimmune diseases...
  84. ncbi request reprint Immunomodulation for treatment and prevention of atherosclerosis
    Yaniv Sherer
    Department of Medicine B, Sheba Medical Center, Tel Hashomer, 52621, Israel
    Autoimmun Rev 1:21-7. 2002
    ..These include immunosuppression, active immunization, induction of tolerance, administration of intravenous immunoglobulin, gene therapy, cytokine network manipulation and statins...
  85. ncbi request reprint Tobacco smoking and autoimmune rheumatic diseases
    Michal Harel-Meir
    Department of Medicine B, Chaim Sheba Medical Center, Tel Hashomer, Israel
    Nat Clin Pract Rheumatol 3:707-15. 2007
    ..Further studies, perhaps using animal models, are needed to analyze the exact effect of smoking on each disease separately...
  86. ncbi request reprint HIV and autoimmunity
    Gisele Zandman-Goddard
    Center for Autoimmune Diseases, Department of Medicine B, Sheba Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Hashomer 52621, Israel
    Autoimmun Rev 1:329-37. 2002
    ..In this review, we describe the various autoimmune diseases that develop in HIV/AIDS patients through possible mechanisms related to immune activation...
  87. ncbi request reprint B cell targeted therapy in autoimmunity
    Miri Blank
    The Center for Autoimmune Diseases, Sheba Medical Center, Tel Hashomer, Israel
    J Autoimmun 28:62-8. 2007
    ..This review focuses on some of the emerging therapies based on co-stimulation blockers, and compounds which contribute to a specific B cells depletion, based on studies in animal models and human clinical studies...
  88. ncbi request reprint Inhibition of ras by farnesylthiosalicylate significantly reduces the levels of autoantibodies in two animal models of the antiphospholipid syndrome
    Aviva Katzav
    Dept of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel Aviv, Israel
    Immunobiology 207:47-50. 2003
    ..Antiphospholipid antibodies (aPL) are a heterogeneous group of antibodies detected in patients with antiphospholipid syndrome (APS), which is associated with thrombosis, pregnancy losses, and thrombocytopenia...
  89. ncbi request reprint Mechanisms of disease: atherosclerosis in autoimmune diseases
    Yaniv Sherer
    Department of Medicine B and of the Center for Autoimmune Diseases at Sheba Medical Center, Tel Hashomer, Israel
    Nat Clin Pract Rheumatol 2:99-106. 2006
    ..In this article, we briefly review the contribution of autoimmune elements, such as autoreactive lymphocytes and autoantibodies to atherosclerosis and discuss the nature of atherosclerosis in autoimmune rheumatic diseases...
  90. ncbi request reprint The involvement of beta2-glycoprotein I (beta2-GPI) in human and murine atherosclerosis
    J George
    Department of Medicine B and the Research Unit of Autoimmune Diseases, Sheba Medical Center, Tel Hashomer, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    J Autoimmun 13:57-60. 1999
    ..Thus, the immune response towards beta2-GPI may play an important role in atherogenesis, serving as a possible target for antigen specific therapies...
  91. ncbi request reprint Protective molecules--C-reactive protein (CRP), serum amyloid P (SAP), pentraxin3 (PTX3), mannose-binding lectin (MBL), and apolipoprotein A1 (Apo A1), and their autoantibodies: prevalence and clinical significance in autoimmunity
    Martine Szyper Kravitz
    Center for Autoimmune Diseases and Department of Medicine B, Chaim Sheba Medical Center Tel Hashomer, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    J Clin Immunol 25:582-91. 2005
    ....
  92. ncbi request reprint Antiphospholipid antibodies: are they pro-atherogenic or an epiphenomenon of atherosclerosis?
    Yaniv Sherer
    Department of Medicine B and Center of Autoimmune Diseases, Sheba Medical Center, Tel Hashomer, Israel
    Immunobiology 207:13-6. 2003
    ....
  93. ncbi request reprint The story of the 16/6 idiotype and systemic lupus erythematosus
    Miri Blank
    Center for Autoimmune Diseases and Department of Internal Medicine B, Sheba Medical Center, Tel Hashomer, Israel
    Isr Med Assoc J 10:37-9. 2008
    ..We also discuss various therapeutic modalities to treat 16/6 induced lupus in mice...
  94. ncbi request reprint Immunomodulatory effects of intravenous immunoglobulins as a treatment for autoimmune diseases, cancer, and recurrent pregnancy loss
    Tal Sapir
    Department of Internal Medicine B and Research Center for Autoimmune Diseases, Sheba Medical Center, Tel Hashomer 52621, Israel
    Ann N Y Acad Sci 1051:743-78. 2005
    ..The only downside of IVIG therapy is its high price. Therefore, clinicians should balance efficiency versus cost in deciding whether or not to treat certain conditions with IVIG...
  95. ncbi request reprint Low levels of heat shock proteins-60 and -65 autoantibodies in Sjögren's syndrome
    Ora Shovman
    Department of Medicine B and Center of Autoimmune Diseases, Sheba Medical Center, Tel Hashomer, Israel
    Isr Med Assoc J 7:778-80. 2005
    ..Heat shock proteins are highly conserved immunodominant antigens found in various species. Humoral immune responses to mycobacterial HSP65 and human HSP60 have been established in a number of human autoimmune diseases...
  96. ncbi request reprint Glucocorticoids and the cardiovascular system: state of the art
    Udi Nussinovitch
    Department of Internal Medicine B, Sheba Medical Center, Tel Hashomer, Tel Aviv University, Israel
    Curr Pharm Des 16:3574-85. 2010
    ..Some of the well-known side effects of GC therapy involve bone, metabolic, and cardiovascular systems and include osteoporosis, fractures, dyslipidemia, diabetes, obesity, and hypertension...
  97. ncbi request reprint Prevalence of antiphospholipid and antioxidized low-density lipoprotein antibodies in rheumatoid arthritis
    Yaniv Sherer
    Department of Medicine B and Center of Autoimmune Diseases, Sheba Medical Center, Tel Hashomer 52621, Israel
    Ann N Y Acad Sci 1051:299-303. 2005
    ..Whether the presence of anticardiolipin signifies increased risk for thrombosis and atherosclerosis in these patients should be studied further...
  98. ncbi request reprint Vaccination may be associated with autoimmune diseases
    Moshe Tishler
    Department of Medicine B, Assaf Harofe Medical Center, Zerifin, Israel
    Isr Med Assoc J 6:430-2. 2004
  99. ncbi request reprint Beta-2-glycoprotein-I, infections, antiphospholipid syndrome and therapeutic considerations
    Miri Blank
    Department of Medicine B and The Center for Autoimmune Diseases, Sheba Medical Center, Tel Hashomer 52621, Israel
    Clin Immunol 112:190-9. 2004
    ..In this paper, we discuss the association of antiphospholipid antibodies, infectious states, and molecular mimicry as a proposed mechanism for development of APS...
  100. doi request reprint The detection of pleural effusion using a parametric EIT technique
    M Arad
    Department of Geriatric Medicine and Rehabilitation, Sheba Medical Center, Tel Hashomer, and Sackler Faculty of Medicine, Tel Aviv University, Israel
    Physiol Meas 30:421-8. 2009
    ..53). The present study further supports the feasibility and applicability of the bioimpedance technique, and specifically the approach of parametric left and right lung resistivity reconstruction, in monitoring lung patients...
  101. ncbi request reprint Non-stroke neurological syndromes associated with antiphospholipid antibodies: evaluation of clinical and experimental studies
    J Chapman
    Department of Neurology, Sheba Medical Center, Tel Hashomer 52621, Israel
    Lupus 12:514-7. 2003
    ....