Y Shiloh

Summary

Affiliation: Tel Aviv University
Country: Israel

Publications

  1. pmc The histone H2B-specific ubiquitin ligase RNF20/hBRE1 acts as a putative tumor suppressor through selective regulation of gene expression
    Efrat Shema
    Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot 76100, Israel
    Genes Dev 22:2664-76. 2008
  2. ncbi The ATM-mediated DNA-damage response: taking shape
    Yosef Shiloh
    The David and Inez Myers Laboratory for Genetic Research, Department of Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel
    Trends Biochem Sci 31:402-10. 2006
  3. ncbi The ATM protein kinase: regulating the cellular response to genotoxic stress, and more
    Yosef Shiloh
    The David and Inez Myers Laboratory for Cancer Genetics, Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel
    Nat Rev Mol Cell Biol 14:197-210. 2013
  4. doi The ATM protein kinase: regulating the cellular response to genotoxic stress, and more
    Yosef Shiloh
    The David and Inez Myers Laboratory for Cancer Genetics, Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel
    Nat Rev Mol Cell Biol 14:197-210. 2013
  5. pmc The ATM protein: the importance of being active
    Yosef Shiloh
    The David and Inez Myers Laboratory for Cancer Genetics, Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel
    J Cell Biol 198:273-5. 2012
  6. pmc Dissection of a DNA-damage-induced transcriptional network using a combination of microarrays, RNA interference and computational promoter analysis
    Ran Elkon
    The David and Inez Myers Laboratory for Genetic Research, Department of Human Genetics, Sackler School of Medicine, Tel Aviv University, Tel Aviv, 69978, Israel
    Genome Biol 6:R43. 2005
  7. pmc Functional genomic delineation of TLR-induced transcriptional networks
    Ran Elkon
    The David and Inez Myers Laboratory for Genetic Research, Department of Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel
    BMC Genomics 8:394. 2007
  8. pmc SPIKE--a database, visualization and analysis tool of cellular signaling pathways
    Ran Elkon
    The David and Inez Myers Laboratory for Genetic Research, Department of Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel
    BMC Bioinformatics 9:110. 2008
  9. pmc EXPANDER--an integrative program suite for microarray data analysis
    Ron Shamir
    School of Computer Science, Sackler Faculty of Exact Sciences, Tel Aviv University, Tel Aviv 69978, Israel
    BMC Bioinformatics 6:232. 2005
  10. ncbi ATM and related protein kinases: safeguarding genome integrity
    Yosef Shiloh
    The David and Inez Myers Laboratory for Genetic Research, Department of Human Genetics and Molecular Medicine, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel
    Nat Rev Cancer 3:155-68. 2003

Detail Information

Publications70

  1. pmc The histone H2B-specific ubiquitin ligase RNF20/hBRE1 acts as a putative tumor suppressor through selective regulation of gene expression
    Efrat Shema
    Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot 76100, Israel
    Genes Dev 22:2664-76. 2008
    ..Furthermore, frequent RNF20 promoter hypermethylation was observed in tumors. RNF20 may thus be a putative tumor suppressor, acting through selective regulation of a distinct subset of genes...
  2. ncbi The ATM-mediated DNA-damage response: taking shape
    Yosef Shiloh
    The David and Inez Myers Laboratory for Genetic Research, Department of Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel
    Trends Biochem Sci 31:402-10. 2006
    ..Genetic, biochemical and structural studies have recently provided insights into the ATM-mediated DSB response, reshaping our view of this signaling pathway while raising new questions...
  3. ncbi The ATM protein kinase: regulating the cellular response to genotoxic stress, and more
    Yosef Shiloh
    The David and Inez Myers Laboratory for Cancer Genetics, Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel
    Nat Rev Mol Cell Biol 14:197-210. 2013
    ..Moreover, it has become apparent that ATM is active in other cell signalling pathways involved in maintaining cellular homeostasis...
  4. doi The ATM protein kinase: regulating the cellular response to genotoxic stress, and more
    Yosef Shiloh
    The David and Inez Myers Laboratory for Cancer Genetics, Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel
    Nat Rev Mol Cell Biol 14:197-210. 2013
    ..Moreover, it has become apparent that ATM is active in other cell signalling pathways involved in maintaining cellular homeostasis...
  5. pmc The ATM protein: the importance of being active
    Yosef Shiloh
    The David and Inez Myers Laboratory for Cancer Genetics, Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel
    J Cell Biol 198:273-5. 2012
    ..This is surprising because mice completely lacking ATM have a much more moderate phenotype. The findings impact on basic cancer research and cancer therapeutics...
  6. pmc Dissection of a DNA-damage-induced transcriptional network using a combination of microarrays, RNA interference and computational promoter analysis
    Ran Elkon
    The David and Inez Myers Laboratory for Genetic Research, Department of Human Genetics, Sackler School of Medicine, Tel Aviv University, Tel Aviv, 69978, Israel
    Genome Biol 6:R43. 2005
    ....
  7. pmc Functional genomic delineation of TLR-induced transcriptional networks
    Ran Elkon
    The David and Inez Myers Laboratory for Genetic Research, Department of Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel
    BMC Genomics 8:394. 2007
    ..We sought global delineation of transcriptional networks induced by TLRs, analyzing four genome-wide expression datasets in mouse and human macrophages stimulated with pathogen-mimetic agents that engage various TLRs...
  8. pmc SPIKE--a database, visualization and analysis tool of cellular signaling pathways
    Ran Elkon
    The David and Inez Myers Laboratory for Genetic Research, Department of Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel
    BMC Bioinformatics 9:110. 2008
    ..The assimilation, visualization and interpretation of these data have become a major challenge in biological research, and once met, will greatly boost our ability to understand cell functioning on a systems level...
  9. pmc EXPANDER--an integrative program suite for microarray data analysis
    Ron Shamir
    School of Computer Science, Sackler Faculty of Exact Sciences, Tel Aviv University, Tel Aviv 69978, Israel
    BMC Bioinformatics 6:232. 2005
    ..Of special need are integrative packages that provide biologist users with advanced but yet easy to use, set of algorithms, together covering the whole range of steps in microarray data analysis...
  10. ncbi ATM and related protein kinases: safeguarding genome integrity
    Yosef Shiloh
    The David and Inez Myers Laboratory for Genetic Research, Department of Human Genetics and Molecular Medicine, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel
    Nat Rev Cancer 3:155-68. 2003
    ..Understanding ATM's mode of action provides new insights into the association between defective responses to DNA damage and cancer, and brings us closer to resolving the issue of cancer predisposition in some A-T carriers...
  11. ncbi ATM (ataxia telangiectasia mutated): expanding roles in the DNA damage response and cellular homeostasis
    Y Shiloh
    The David and Inez Myers Laboratory for Genetic Research, Department of Human Genetics and Molecular Medicine, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel
    Biochem Soc Trans 29:661-6. 2001
    ..The AT phenotype and the functions of the ATM protein revealed to date demonstrate the exceptionally multifaceted nature of this protein...
  12. ncbi ATM: ready, set, go
    Yosef Shiloh
    The Dovid and Inez Myers Laboratory lor Genetic Research, Department of Human Genetics and Molecular Medicine, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel
    Cell Cycle 2:116-7. 2003
  13. ncbi Maintaining integrity
    Yosef Shiloh
    The David and Inez Myers Laboratory for Genetic Research, Department of Human Genetics and Molecular Medicine, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel
    Nat Cell Biol 6:923-8. 2004
    ..Current progress in this rapidly expanding field was the subject of an EMBO workshop, Maintenance of Genomic Integrity, that took place in June 2004 in Galway, Ireland. Top..
  14. ncbi In search of drug treatment for genetic defects in the DNA damage response: the example of ataxia-telangiectasia
    Yosef Shiloh
    Department of Human Genetics and Molecular Medicine, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel
    Semin Cancer Biol 14:295-305. 2004
    ..This article describes a high throughput strategy for drug screening for A-T that is based on the above principles. A similar strategy can potentially be applied to drug screening for other genetic disorders...
  15. ncbi ATM and ATR: networking cellular responses to DNA damage
    Y Shiloh
    Department of Human Genetics and Molecular Medicine, Sackler School of Medicine, Tel Aviv University, 69978, Tel Aviv, Israel
    Curr Opin Genet Dev 11:71-7. 2001
    ..Understanding their mode of action is essential to our understanding of how cells cope with genotoxic stress...
  16. doi RNF20-RNF40: A ubiquitin-driven link between gene expression and the DNA damage response
    Yosef Shiloh
    The David and Inez Myers Laboratory for Cancer Genetics, Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel
    FEBS Lett 585:2795-802. 2011
    ..This pathway represents a crossroads of the DDR and chromatin organization, and is a typical example of how the DDR calls to action functional modules that in unprovoked cells regulate other processes...
  17. pmc Genotype-phenotype relationships in ataxia-telangiectasia and variants
    S Gilad
    Department of Human Genetics, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
    Am J Hum Genet 62:551-61. 1998
    ..We conclude that certain "A-T variant" phenotypes represent ATM mutations, including some of those without telangiectasia. Our findings extend the range of phenotypes associated with ATM mutations...
  18. ncbi The complete sequence of the coding region of the ATM gene reveals similarity to cell cycle regulators in different species
    K Savitsky
    Department of Human Genetics, Sackler School of Medicine, Tel Aviv University, Ramat Aviv, Israel
    Hum Mol Genet 4:2025-32. 1995
    ..The complete sequence of the ATM gene product provides useful clues to the function of this protein, and furthers understanding of the pleiotropic nature of the A-T mutations...
  19. ncbi Predominance of null mutations in ataxia-telangiectasia
    S Gilad
    Department of Human Genetics, Sackler School of Medicine, Tel Aviv University, Ramat Aviv, Israel
    Hum Mol Genet 5:433-9. 1996
    ..The emerging profile of mutations causing A-T is thus dominated by those expected to completely inactivate the ATM protein. ATM mutations with milder effects may result in phenotypes related, but not identical, to A-T...
  20. ncbi Human cDNA clones that modify radiomimetic sensitivity of ataxia-telangiectasia (group A) cells
    Y Ziv
    Department of Human Genetics, Sackler School of Medicine, Tel Aviv University, Ramat Aviv, Israel
    Somat Cell Mol Genet 21:99-111. 1995
    ....
  21. ncbi ATM: from gene to function
    G Rotman
    Department of Human Genetics and Molecular Medicine, Sackler School of Medicine, Tel Aviv University, Ramat Aviv 69978, Israel
    Hum Mol Genet 7:1555-63. 1998
    ..Other roles outside the cell nucleus might be carried out by the cytoplasmic fraction of ATM. In addition, ATM appears to function as a 'caretaker', suppressing tumorigenesis in specific T cell lineages...
  22. ncbi Identification and chromosomal localization of Atm, the mouse homolog of the ataxia-telangiectasia gene
    I Pecker
    Department of Human Genetics, Tel Aviv University, Ramat Aviv, 69978, Israel
    Genomics 35:39-45. 1996
    ..Fluorescence in situ hybridization and linkage analysis located the Atm gene on mouse chromosome 9, band 9C, in a region homologous to the ATM region on human chromosome 11q22-q23...
  23. ncbi Ataxia-telangiectasia: founder effect among north African Jews
    S Gilad
    Department of Human Genetics, Sackler School of Medicine, Tel Aviv University, Ramat Aviv, Israel
    Hum Mol Genet 5:2033-7. 1996
    ..This founder effect provides a unique opportunity for population-based screening for A-T carriers in a large Jewish community...
  24. pmc Ataxia-telangiectasia: structural diversity of untranslated sequences suggests complex post-transcriptional regulation of ATM gene expression
    K Savitsky
    Department of Human Genetics, Sackler School of Medicine, Tel Aviv University, Ramat Aviv 69978, Israel
    Nucleic Acids Res 25:1678-84. 1997
    ....
  25. ncbi ATM: genome stability, neuronal development, and cancer cross paths
    Y Shiloh
    Department of Human Genetics and Molecular Medicine, Sackler School of Medicine, Tel Aviv University, Israel
    Adv Cancer Res 83:209-54. 2001
    ....
  26. ncbi Enhanced phosphorylation of p53 by ATM in response to DNA damage
    S Banin
    Department of Human Genetics and Molecular Medicine, Sackler School of Medicine, Tel Aviv University, Ramat Aviv 69978, Israel
    Science 281:1674-7. 1998
    ..Various damage-induced responses may be activated by enhancement of the protein kinase activity of ATM...
  27. ncbi A human gene (DDX10) encoding a putative DEAD-box RNA helicase at 11q22-q23
    K Savitsky
    Department of Human Genetics, Sackler School of Medicine, Tel Aviv University, Ramat Aviv, Israel
    Genomics 33:199-206. 1996
    ..2-kb transcript in a variety of human tissues. A processed pseudogene of DDX10 was detected at chromosome 9q21-q22. We observed a rare trinucleotide repeat length polymorphism within the coding sequence of DDX10...
  28. ncbi Nuclear retention of ATM at sites of DNA double strand breaks
    Y Andegeko
    David and Inez Myers Laboratory for Genetic Research, Department of Human Genetics and Molecular Medicine, Interdepartmental Core Facility, Sackler School of Medicine, Tel Aviv University, Ramat Aviv 69978, Israel
    J Biol Chem 276:38224-30. 2001
    ....
  29. pmc Rapid ATM-dependent phosphorylation of MDM2 precedes p53 accumulation in response to DNA damage
    R Khosravi
    Department of Human Genetics, Sackler School of Medicine, Tel Aviv University, Ramat Aviv 69978, Israel
    Proc Natl Acad Sci U S A 96:14973-7. 1999
    ..These findings suggest that in response to DNA strand breaks, ATM may promote p53 activity and stability by mediating simultaneous phosphorylation of both partners of the p53-MDM2 autoregulatory feedback loop...
  30. ncbi Impaired genomic stability and increased oxidative stress exacerbate different features of Ataxia-telangiectasia
    Shelly Ziv
    Department of Neurobiochemistry, George S Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv 69978, Israel
    Hum Mol Genet 14:2929-43. 2005
    ....
  31. ncbi Nuclear ataxia-telangiectasia mutated (ATM) mediates the cellular response to DNA double strand breaks in human neuron-like cells
    Sharon Biton
    The David and Inez Myers Laboratory for Genetic Research, Department of Molecular Genetics and Biochemistry, Tel Aviv University, Tel Aviv 69978, Israel
    J Biol Chem 281:17482-91. 2006
    ..We concluded that nuclear ATM mediates the DSB response in NLCs similarly to in proliferating cells. Attempts to understand the neurodegeneration in A-T should be directed to investigating the DSB response in the nervous system...
  32. ncbi Parallel induction of ATM-dependent pro- and antiapoptotic signals in response to ionizing radiation in murine lymphoid tissue
    S Rashi-Elkeles
    The David and Inez Myers Laboratory for Genetic Research, Department of Human Genetics, Sackler School of Medicine, Tel Aviv, Israel
    Oncogene 25:1584-92. 2006
    ..The emerging model suggests that restoring the p53-mediated apoptotic arm while blocking the NF-kappaB-mediated prosurvival arm could effectively increase the radiosensitivity of lymphoid tumors...
  33. ncbi A single ataxia telangiectasia gene with a product similar to PI-3 kinase
    K Savitsky
    Department of Human Genetics, Sackler School of Medicine, Tel Aviv University, Israel
    Science 268:1749-53. 1995
    ..The discovery of ATM should enhance understanding of AT and related syndromes and may allow the identification of AT heterozygotes, who are at increased risk of cancer...
  34. ncbi Increased oxidative stress in ataxia telangiectasia evidenced by alterations in redox state of brains from Atm-deficient mice
    A Kamsler
    Department of Neurobiochemistry, George S. Wise Faculty of Life Sciences, Tel Aviv University, Israel
    Cancer Res 61:1849-54. 2001
    ..Our findings support the hypothesis that the absence of functional ATM results in oxidative stress, which may be an important cause of the degeneration of cerebellar neurons in A-T...
  35. pmc Requirement of the MRN complex for ATM activation by DNA damage
    Tamar Uziel
    The David and Inez Myers Laboratory for Genetic Research, Department of Human Genetics and Molecular Medicine, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel
    EMBO J 22:5612-21. 2003
    ..Collectively, these and previous results assign to components of the MRN complex roles upstream and downstream of ATM in the DNA damage response pathway and explain the clinical resemblance between A-T and A-TLD...
  36. pmc Phosphorylation of Hdmx mediates its Hdm2- and ATM-dependent degradation in response to DNA damage
    Yaron Pereg
    The David and Inez Myers Laboratory for Genetic Research, Department of Human Genetics and Molecular Medicine, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel
    Proc Natl Acad Sci U S A 102:5056-61. 2005
    ..These results demonstrate a sophisticated mechanism whereby ATM fine-tunes the optimal activation of p53 by simultaneously modifying each player in the process...
  37. ncbi ATM-dependent activation of the gene encoding MAP kinase phosphatase 5 by radiomimetic DNA damage
    Anat Bar-Shira
    The David and Inez Myers Laboratory for Genetic Research, Department of Human Genetics and Molecular Medicine, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel
    Oncogene 21:849-55. 2002
    ..Thus, ATM modulates this cycle in response to DSBs. These results further highlight ATM as a link between the DNA damage response and major signaling pathways involved in proliferative and apoptotic processes...
  38. ncbi Contribution of the Atm protein to maintaining cellular homeostasis evidenced by continuous activation of the AP-1 pathway in Atm-deficient brains
    Nir Weizman
    Department of Neurobiochemistry, George S Wise Faculty of Life Sciences, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978 Israel
    J Biol Chem 278:6741-7. 2003
    ..Our results further demonstrate that inactivation of the ATM gene results in a state of constant stress...
  39. doi The neurological phenotype of ataxia-telangiectasia: solving a persistent puzzle
    Sharon Biton
    Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel
    DNA Repair (Amst) 7:1028-38. 2008
    ..A-T remains a prototype disease for the study of the DDR's role in CNS development and maintenance...
  40. pmc Differential roles of ATM- and Chk2-mediated phosphorylations of Hdmx in response to DNA damage
    Yaron Pereg
    Department of Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel
    Mol Cell Biol 26:6819-31. 2006
    ..These results demonstrate a sophisticated control by ATM of a target protein, Hdmx, which itself is one of several ATM targets in the ATM-p53 axis of the DNA damage response...
  41. ncbi ATM deficiency and oxidative stress: a new dimension of defective response to DNA damage
    Ari Barzilai
    Department of Neurobiochemistry, George S Wise Faculty of Life Sciences, Tel Aviv University, 69978, Tel Aviv, Israel
    DNA Repair (Amst) 1:3-25. 2002
    ..This connection may provide new insights into the phenotypes associated with genetic deficiencies of DNA damage responses, and point to new strategies to alleviate some of their clinical symptoms...
  42. doi Analysis of the relationships between ATM and the Rad54 paralogs involved in homologous recombination repair
    Michal Kirshner
    Department of Neurobiology, George S Wise, Faculty of Life Sciences, Tel Aviv University, Tel Aviv 69978, Israel
    DNA Repair (Amst) 8:253-61. 2009
    ..Our results reveal a differential interaction of the ATM-mediated DNA damage response and Rad54 paralog-mediated HR depending on the DNA damaging agent that initiates the response...
  43. ncbi ATM-mediated response to DNA double strand breaks in human neurons derived from stem cells
    Sharon Biton
    David and Inez Myers Laboratory for Genetic Research, Department of Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel
    DNA Repair (Amst) 6:128-34. 2007
    ..We present here unique and powerful model systems to further study the ATM-mediated network in neurons...
  44. ncbi Analysis of the ataxia telangiectasia mutated-mediated DNA damage response in murine cerebellar neurons
    Inbal Dar
    Department of Neurobiochemistry, George S Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv 69978, Israel
    J Neurosci 26:7767-74. 2006
    ..These results support the notion that the cerebellar degeneration in A-T patients results from defective DNA damage response...
  45. ncbi Ataxia-telangiectasia: mild neurological presentation despite null ATM mutation and severe cellular phenotype
    Neora Alterman
    The David and Inez Myers Laboratory for Genetic Research, Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
    Am J Med Genet A 143:1827-34. 2007
    ..This analysis shows that the severity of the neurological component of A-T is determined not only by ATM mutations but also by other influences yet to be found...
  46. pmc Genome-wide in silico identification of transcriptional regulators controlling the cell cycle in human cells
    Ran Elkon
    The David and Inez Myers Laboratory for Genetic Research, Department of Human Genetics, Sackler School of Medicine, and School of Computer Science, Tel Aviv University, Tel Aviv 69978, Israel
    Genome Res 13:773-80. 2003
    ..The methods presented here are general and can be applied to the analysis of transcriptional networks controlling any biological process...
  47. ncbi Accumulation of DNA damage and reduced levels of nicotine adenine dinucleotide in the brains of Atm-deficient mice
    Nora Stern
    Department of Neurobiochemistry, George S Wise Faculty of Life Sciences, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel
    J Biol Chem 277:602-8. 2002
    ..Taken together, our findings support the hypothesis that absence of functional ATM results in continuous stress, which may be an important cause of the degeneration of cerebellar neurons in A-T...
  48. pmc Condensin I recruitment and uneven chromatin condensation precede mitotic cell death in response to DNA damage
    Michael Blank
    The David and Inez Myers Laboratory for Genetic Research, Department of Molecular Genetics and Biochemistry, and Interdepartmental Core Facility, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel
    J Cell Biol 174:195-206. 2006
    ....
  49. ncbi Absence of mutations in ATM, the gene responsible for ataxia telangiectasia in patients with cerebellar ataxia
    S Hassin-Baer
    Department of Neurology, Chaim Sheba Medical Center, Tel Hashomer, Israel
    J Neurol 246:716-9. 1999
    ..In this heterogeneous group of patients with cerebellar ataxia we found no mutations in the ATM gene. We conclude that mutations in the ATM gene are probably not a common cause for cerebellar ataxia other than AT...
  50. doi The role of the DNA damage response in neuronal development, organization and maintenance
    Ari Barzilai
    Department of Neurobiology, George S Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv 69978, Israel
    DNA Repair (Amst) 7:1010-27. 2008
    ..This review focuses on the DNA damage response in neuronal cells and points to the importance of this elaborate network to the integrity of the nervous system from its early development and throughout the lifetime of the organism...
  51. ncbi Chromatin relaxation in response to DNA double-strand breaks is modulated by a novel ATM- and KAP-1 dependent pathway
    Yael Ziv
    The David and Inez Myers Laboratory for Genetic Research, Department of Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel
    Nat Cell Biol 8:870-6. 2006
    ..These results suggest that chromatin relaxation is a fundamental pathway in the DNA-damage response and identify its primary mediators...
  52. ncbi PIVOT: protein interacions visualizatiOn tool
    Nir Orlev
    Department of Human Genetics, Faculty of Medicine, Tel Aviv University, Israel
    Bioinformatics 20:424-5. 2004
    ..The user can also employ PIVOT to predict unknown interactions among proteins, based on interactions among their homologous proteins in other species...
  53. pmc Genetic mapping of X-linked albinism-deafness syndrome (ADFN) to Xq26.3-q27.I
    Y Shiloh
    Department of Human Genetics, Sackler School of Medicine, Tel Aviv University, Israel
    Am J Hum Genet 47:20-7. 1990
    ..Together with the linkage data, our results place DXS91 at Xq26 and underscore the importance of using more than one mapping method for the localization of molecular probes...
  54. doi Expander: from expression microarrays to networks and functions
    Igor Ulitsky
    Blavatnik School of Computer Science, Tel Aviv University, Tel Aviv, Israel
    Nat Protoc 5:303-22. 2010
    ..The results of each analysis step can be visualized in a number of ways. The complete protocol can be executed in approximately 1 h...
  55. ncbi Ataxia-telangiectasia and the Nijmegen breakage syndrome: related disorders but genes apart
    Y Shiloh
    Department of Human Genetics, Sackler School of Medicine, Tel Aviv University, Israel
    Annu Rev Genet 31:635-62. 1997
    ..The as yet unknown NBS protein may be a component in an ATM-based complex, with a key role in sensing and processing specific DNA damage or intermediates and signaling their presence to the cell cycle machinery...
  56. ncbi MRI evidence of white matter damage in a mouse model of Nijmegen breakage syndrome
    Yaniv Assaf
    Department of Neurobiochemistry, George S Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel
    Exp Neurol 209:181-91. 2008
    ..Myelin index and protein levels were significantly reduced in these brains. Our results point to a novel function of Nbs1 in the development and organization of the white matter...
  57. pmc Phenylketonuria: variable phenotypic outcomes of the R261Q mutation and maternal PKU in the offspring of a healthy homozygote
    S Kleiman
    Department of Human Genetics, Sackler School of Medicine, Tel Aviv University, Ramat Aviv, Israel
    J Med Genet 30:284-8. 1993
    ..Compound heterozygosity for R261Q and other mutations led in other patients either to classical PKU or to mild benign HPA...
  58. doi FBXO31: a new player in the ever-expanding DNA damage response orchestra
    Yosef Shiloh
    The David and Inez Myers Laboratory for Cancer Genetics, Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel
    Sci Signal 2:pe73. 2009
    ..A new pathway driving this checkpoint draws attention to the complexity of the DDR, which allows tight but fine-tuned control of the cellular response to threats to genomic integrity...
  59. doi Conditional inactivation of the NBS1 gene in the mouse central nervous system leads to neurodegeneration and disorganization of the visual system
    Koby Baranes
    Department of Neurobiology, George S Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, 69978 Israel
    Exp Neurol 218:24-32. 2009
    ..Electroretinogram analysis revealed marked reduction in a- and b-waves, indicative of decreased retinal function. Our study points to a novel role for Nbs1 in the development, organization and function of the visual system...
  60. pmc In silico identification of transcriptional regulators associated with c-Myc
    Ran Elkon
    The David and Inez Myers Laboratory for Genetic Research, Department of Human Genetics, Sackler School of Medicine, Tel Aviv University, Israel
    Nucleic Acids Res 32:4955-61. 2004
    ..The approach applied here is general and demonstrates how computational analysis of functional genomics experiments can identify novel modules in complex networks of transcriptional regulation...
  61. ncbi Deciphering transcriptional regulatory elements that encode specific cell cycle phasing by comparative genomics analysis
    Chaim Linhart
    School of Computer Science, Tel Aviv University, Tel Aviv, Israel
    Cell Cycle 4:1788-97. 2005
    ..Our results reveal novel modules that determine specific cell cycle phasing, and identify their respective putative target genes with remarkably high specificity...
  62. doi ATM signaling facilitates repair of DNA double-strand breaks associated with heterochromatin
    Aaron A Goodarzi
    Genome Damage and Stability Centre, University of Sussex, East Sussex BN1 9RQ, UK
    Mol Cell 31:167-77. 2008
    ..These data suggest that the importance of ATM signaling for DSB repair increases as the heterochromatic component of a genome expands...
  63. ncbi Ataxia telangiectasia mutated (ATM) is essential for DNA-PKcs phosphorylations at the Thr-2609 cluster upon DNA double strand break
    Benjamin P C Chen
    Division of Molecular Radiation Biology, Department of Radiation Oncology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390, USA
    J Biol Chem 282:6582-7. 2007
    ..Finally, our result provides a possible mechanism for the direct involvement of ATM in non-homologous end joining-mediated DSB repair...
  64. ncbi Inhibition of transforming growth factor-beta1 signaling attenuates ataxia telangiectasia mutated activity in response to genotoxic stress
    Julia Kirshner
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California, USA
    Cancer Res 66:10861-9. 2006
    ....
  65. pmc DNA damage-induced phosphorylation of MdmX at serine 367 activates p53 by targeting MdmX for Mdm2-dependent degradation
    Koji Okamoto
    Radiobiology Division, National Cancer Center Research Institute, Tsukiji 5 1 1, Chuo Ku, Tokyo 104 0045, Japan
    Mol Cell Biol 25:9608-20. 2005
    ..We propose that Mdmx phosphorylation at S367 plays an important role in p53 activation after DNA damage by triggering Mdm2-dependent degradation of Mdmx...
  66. ncbi Ubiquitination capabilities in response to neocarzinostatin and H(2)O(2) stress in cell lines from patients with ataxia-telangiectasia
    Allen Taylor
    JM USDA Human Nutrition Research Center on Aging at Tufts University, Laboratory for Nutrition and Vision Research, 711 Washington Street, Boston, Massachusetts 02111, USA
    Oncogene 21:4363-73. 2002
    ..The data also add support to the impression that potentiated ubiquitination response to mild oxidative stress is a generalizable phenomenon...
  67. pmc Ionizing radiation induces ataxia telangiectasia mutated kinase (ATM)-mediated phosphorylation of LKB1/STK11 at Thr-366
    Gopal P Sapkota
    MRC Protein Phosphorylation Unit, MSI WTB complex, University of Dundee, Dow Street, Dundee DD1 5EH, Scotland, U K
    Biochem J 368:507-16. 2002
    ..These observations provide the first link between ATM and LKB1 and suggest that ATM could regulate LKB1...
  68. ncbi ATM-mediated phosphorylations inhibit Mdmx/Mdm2 stabilization by HAUSP in favor of p53 activation
    Erik Meulmeester
    Department of Molecular and Cell Biology, Leiden University Medical Center, Leiden, The Netherlands
    Cell Cycle 4:1166-70. 2005
    ..Further insight into the mechanism by which ATM switches the interactions between HAUSP, Mdmx, Mdm2 and p53, to favor p53 activation may offer new tools for therapeutic intervention in the p53 pathway for cancer treatment...
  69. pmc ATM-dependent phosphorylation of ATF2 is required for the DNA damage response
    Anindita Bhoumik
    Signal Transduction Program, The Burnham Institute, La Jolla, California 92037, USA
    Mol Cell 18:577-87. 2005
    ..ATF2 requires neither JNK/p38 nor its DNA binding domain for recruitment to IRIF and the S phase checkpoint. Our findings identify a role for ATF2 in the DNA damage response that is uncoupled from its transcriptional activity...
  70. ncbi ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage
    Shuhei Matsuoka
    Department of Genetics and Center for Genetics and Genomics, Brigham and Women s Hospital, Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115, USA
    Science 316:1160-6. 2007
    ..This database paints a much broader landscape for the DDR than was previously appreciated and opens new avenues of investigation into the responses to DNA damage in mammals...