Saharon Rosset

Summary

Affiliation: Tel Aviv University
Country: Israel

Publications

  1. pmc Linkage disequilibrium analysis reveals an albuminuria risk haplotype containing three missense mutations in the cubilin gene with striking differences among European and African ancestry populations
    Shay Tzur
    Ruth and Bruce Rappaport Faculty of Medicine and Research Institute, Technion Israel Institute of Technology, Haifa, 31096, Israel
    BMC Nephrol 13:142. 2012
  2. pmc Maximum-likelihood estimation of site-specific mutation rates in human mitochondrial DNA from partial phylogenetic classification
    Saharon Rosset
    Department of Statistics and Operations Research, Tel Aviv University, Tel Aviv, Israel
    Genetics 180:1511-24. 2008
  3. doi request reprint Statistical modeling of coverage in high-throughput data
    David Golan
    School of Mathematical Sciences, Tel Aviv University, Tel Aviv, Israel
    Methods Mol Biol 1038:61-79. 2013
  4. doi request reprint Dyskinesias in patients with Parkinson's disease: effect of the leucine-rich repeat kinase 2 (LRRK2) G2019S mutation
    Gilad Yahalom
    The Parkinson Disease and Movement Disorders Clinic, Sagol Neuroscience Center and Department of Neurology, Tel Aviv University, Israel
    Parkinsonism Relat Disord 18:1039-41. 2012
  5. ncbi request reprint Comment on "the predictive capacity of personal genome sequencing"
    David Golan
    Department of Statistics and Operations Research, Tel Aviv University, Tel Aviv 69978, Israel
    Sci Transl Med 4:135le4. 2012
  6. pmc Weighted pooling--practical and cost-effective techniques for pooled high-throughput sequencing
    David Golan
    School of Mathematical Sciences, Tel Aviv University, Tel Aviv, Israel
    Bioinformatics 28:i197-206. 2012
  7. pmc Maximum likelihood estimation of locus-specific mutation rates in Y-chromosome short tandem repeats
    Osnat Ravid-Amir
    Department of Statistics and Operation Research, Tel Aviv, Israel
    Bioinformatics 26:i440-5. 2010
  8. doi request reprint The population genetics of chronic kidney disease: insights from the MYH9-APOL1 locus
    Saharon Rosset
    Department of Statistics and Operations Research, Tel Aviv University, Tel Aviv 69978, Israel
    Nat Rev Nephrol 7:313-26. 2011
  9. pmc Accurate estimation of heritability in genome wide studies using random effects models
    David Golan
    School of Mathematical Sciences, Tel Aviv University, Tel Aviv, Israel
    Bioinformatics 27:i317-23. 2011

Detail Information

Publications9

  1. pmc Linkage disequilibrium analysis reveals an albuminuria risk haplotype containing three missense mutations in the cubilin gene with striking differences among European and African ancestry populations
    Shay Tzur
    Ruth and Bruce Rappaport Faculty of Medicine and Research Institute, Technion Israel Institute of Technology, Haifa, 31096, Israel
    BMC Nephrol 13:142. 2012
    ..A recent meta-analysis described a variant (p.Ile2984Val) in the cubilin gene (CUBN) that is associated with levels of albuminuria in the general population and in diabetics...
  2. pmc Maximum-likelihood estimation of site-specific mutation rates in human mitochondrial DNA from partial phylogenetic classification
    Saharon Rosset
    Department of Statistics and Operations Research, Tel Aviv University, Tel Aviv, Israel
    Genetics 180:1511-24. 2008
    ..Potential extensions of our methodology include its application to estimation of mutation rates in other genetic regions, like Y chromosome short tandem repeats...
  3. doi request reprint Statistical modeling of coverage in high-throughput data
    David Golan
    School of Mathematical Sciences, Tel Aviv University, Tel Aviv, Israel
    Methods Mol Biol 1038:61-79. 2013
    ..In this chapter we describe the fundamentals of statistical modeling of coverage depth and discuss the problems of estimation and inference in the relevant experimental scenarios...
  4. doi request reprint Dyskinesias in patients with Parkinson's disease: effect of the leucine-rich repeat kinase 2 (LRRK2) G2019S mutation
    Gilad Yahalom
    The Parkinson Disease and Movement Disorders Clinic, Sagol Neuroscience Center and Department of Neurology, Tel Aviv University, Israel
    Parkinsonism Relat Disord 18:1039-41. 2012
    ....
  5. ncbi request reprint Comment on "the predictive capacity of personal genome sequencing"
    David Golan
    Department of Statistics and Operations Research, Tel Aviv University, Tel Aviv 69978, Israel
    Sci Transl Med 4:135le4. 2012
    ..Recalculation of the results in Roberts et al. shows that the true predictive capacity of genomes may be higher than their maximal estimates...
  6. pmc Weighted pooling--practical and cost-effective techniques for pooled high-throughput sequencing
    David Golan
    School of Mathematical Sciences, Tel Aviv University, Tel Aviv, Israel
    Bioinformatics 28:i197-206. 2012
    ..One can then infer the number of carriers in a pool, and by combining information across pools, reconstruct the identity of the carriers...
  7. pmc Maximum likelihood estimation of locus-specific mutation rates in Y-chromosome short tandem repeats
    Osnat Ravid-Amir
    Department of Statistics and Operation Research, Tel Aviv, Israel
    Bioinformatics 26:i440-5. 2010
    ..Here we show a novel method for estimation of site-specific Y-STR mutation rates from partial phylogenetic information, via the maximum likelihood framework...
  8. doi request reprint The population genetics of chronic kidney disease: insights from the MYH9-APOL1 locus
    Saharon Rosset
    Department of Statistics and Operations Research, Tel Aviv University, Tel Aviv 69978, Israel
    Nat Rev Nephrol 7:313-26. 2011
    ..We describe the data sources, process of discovery, and reasons for initial misidentification of the candidate gene, as well as the lessons that can be learned for future population genetics research...
  9. pmc Accurate estimation of heritability in genome wide studies using random effects models
    David Golan
    School of Mathematical Sciences, Tel Aviv University, Tel Aviv, Israel
    Bioinformatics 27:i317-23. 2011
    ..2010) have demonstrated that the heritability of height is much higher than the ~10% associated with identified genetic factors. However, Yang et al. (2010) relied on a heuristic for performing estimation in this model...