Mical Paul

Summary

Affiliation: Tel Aviv University
Country: Israel

Publications

  1. ncbi request reprint Combination therapy for carbapenem-resistant Gram-negative bacteria
    Mical Paul
    Division of Infectious Diseases, Rambam Health Care Campus and the Ruth and Bruce Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    J Antimicrob Chemother 69:2305-9. 2014
  2. pmc Prophylactic antibiotics for burns patients: systematic review and meta-analysis
    Tomer Avni
    Department of Medicine E, Rabin Medical Center, Beilinson Hospital, Sackler Faculty of Medicine, Tel Aviv University, Israel
    BMJ 340:c241. 2010
  3. ncbi request reprint Beta-lactam versus beta-lactam-aminoglycoside combination therapy in cancer patients with neutropenia
    Mical Paul
    Unit of Infectious Diseases, Rambam Health Care Center Haifa, Israel and Sackler Faculty of Medicine, Tel Aviv, Israel
    Cochrane Database Syst Rev 6:CD003038. 2013
  4. doi request reprint Infections in hematogical cancer patients: the contribution of systematic reviews and meta-analyses
    Mical Paul
    Rabin Medical Center, Beilinson Hospital, Tel Aviv University, Israel
    Acta Haematol 125:80-90. 2011
  5. doi request reprint Are all beta-lactams similarly effective in the treatment of methicillin-sensitive Staphylococcus aureus bacteraemia?
    M Paul
    Unit of Infectious Diseases, Rabin Medical Center, Beilinson Hospital, Petah Tikva, Israel
    Clin Microbiol Infect 17:1581-6. 2011
  6. ncbi request reprint Importance of appropriate empirical antibiotic therapy for methicillin-resistant Staphylococcus aureus bacteraemia
    Mical Paul
    Unit of Infectious Diseases, Rabin Medical Center, Beilinson Hospital, Petah Tiqva, Israel
    J Antimicrob Chemother 65:2658-65. 2010
  7. pmc Systematic review and meta-analysis of the efficacy of appropriate empiric antibiotic therapy for sepsis
    Mical Paul
    Unit of Infectious Diseases, Rabin Medical Center, Beilinson Hospital, Petach Tikva, Israel
    Antimicrob Agents Chemother 54:4851-63. 2010
  8. ncbi request reprint Effectiveness and safety of colistin: prospective comparative cohort study
    Mical Paul
    Unit of Infectious Diseases, Rabin Medical Center, Beilinson Hospital, Petah Tikva, Israel
    J Antimicrob Chemother 65:1019-27. 2010
  9. doi request reprint Characteristics of initial compared with subsequent bacterial infections among hospitalised haemato-oncological patients
    Ron Ram
    Institute of Hematology, Davidoff Cancer Center, Beilinson Hospital, Rabin Medical Center, Petah Tikva, Israel
    Int J Antimicrob Agents 40:123-6. 2012
  10. ncbi request reprint Benefit of appropriate empirical antibiotic treatment: thirty-day mortality and duration of hospital stay
    Abigail Fraser
    Department of Medicine E, Rabin Medical Center, Beilinson Campus, Petah Tiqva, Israel
    Am J Med 119:970-6. 2006

Detail Information

Publications89

  1. ncbi request reprint Combination therapy for carbapenem-resistant Gram-negative bacteria
    Mical Paul
    Division of Infectious Diseases, Rambam Health Care Campus and the Ruth and Bruce Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    J Antimicrob Chemother 69:2305-9. 2014
    ..Currently, however, there is no evidence-based support for most combination therapies against CR-GNB, including colistin/carbapenem combination therapy. ..
  2. pmc Prophylactic antibiotics for burns patients: systematic review and meta-analysis
    Tomer Avni
    Department of Medicine E, Rabin Medical Center, Beilinson Hospital, Sackler Faculty of Medicine, Tel Aviv University, Israel
    BMJ 340:c241. 2010
    ..To assess the evidence for prophylactic treatment with systemic antibiotics in burns patients...
  3. ncbi request reprint Beta-lactam versus beta-lactam-aminoglycoside combination therapy in cancer patients with neutropenia
    Mical Paul
    Unit of Infectious Diseases, Rambam Health Care Center Haifa, Israel and Sackler Faculty of Medicine, Tel Aviv, Israel
    Cochrane Database Syst Rev 6:CD003038. 2013
    ..New broad-spectrum beta-lactams have been introduced as single treatment, and classically, a combination of a beta-lactam with an aminoglycoside has been used...
  4. doi request reprint Infections in hematogical cancer patients: the contribution of systematic reviews and meta-analyses
    Mical Paul
    Rabin Medical Center, Beilinson Hospital, Tel Aviv University, Israel
    Acta Haematol 125:80-90. 2011
    ....
  5. doi request reprint Are all beta-lactams similarly effective in the treatment of methicillin-sensitive Staphylococcus aureus bacteraemia?
    M Paul
    Unit of Infectious Diseases, Rabin Medical Center, Beilinson Hospital, Petah Tikva, Israel
    Clin Microbiol Infect 17:1581-6. 2011
    ....
  6. ncbi request reprint Importance of appropriate empirical antibiotic therapy for methicillin-resistant Staphylococcus aureus bacteraemia
    Mical Paul
    Unit of Infectious Diseases, Rabin Medical Center, Beilinson Hospital, Petah Tiqva, Israel
    J Antimicrob Chemother 65:2658-65. 2010
    ....
  7. pmc Systematic review and meta-analysis of the efficacy of appropriate empiric antibiotic therapy for sepsis
    Mical Paul
    Unit of Infectious Diseases, Rabin Medical Center, Beilinson Hospital, Petach Tikva, Israel
    Antimicrob Agents Chemother 54:4851-63. 2010
    ..However, the methods used in the observational studies significantly affect the effect size reported. Methods of observational studies assessing the effects of antibiotic treatment should be improved and standardized...
  8. ncbi request reprint Effectiveness and safety of colistin: prospective comparative cohort study
    Mical Paul
    Unit of Infectious Diseases, Rabin Medical Center, Beilinson Hospital, Petah Tikva, Israel
    J Antimicrob Chemother 65:1019-27. 2010
    ..Colistin has re-entered clinical use by necessity. We aimed to assess its effectiveness and safety compared with newer antibiotics...
  9. doi request reprint Characteristics of initial compared with subsequent bacterial infections among hospitalised haemato-oncological patients
    Ron Ram
    Institute of Hematology, Davidoff Cancer Center, Beilinson Hospital, Rabin Medical Center, Petah Tikva, Israel
    Int J Antimicrob Agents 40:123-6. 2012
    ..Treatment guidelines should address the antibiotic treatment of breakthrough fever...
  10. ncbi request reprint Benefit of appropriate empirical antibiotic treatment: thirty-day mortality and duration of hospital stay
    Abigail Fraser
    Department of Medicine E, Rabin Medical Center, Beilinson Campus, Petah Tiqva, Israel
    Am J Med 119:970-6. 2006
    ..We evaluated the effect of inappropriate antibiotic treatment on mortality and duration of hospital stay in medical inpatients with bacterial infections...
  11. ncbi request reprint The epidemiology of bacteremia with febrile neutropenia: experience from a single center, 1988-2004
    Mical Paul
    Department of Medicine E, Rabin Medical Center Beilinson Campus, Petah Tikva, Israel
    Isr Med Assoc J 9:424-9. 2007
    ..The epidemiology of bacteremic febrile neutropenia differs between locations and constitutes the basis for selection of empiric antibiotic therapy for febrile neutropenia...
  12. ncbi request reprint Subcutaneous versus intravenous granulocyte colony stimulating factor for the treatment of neutropenia in hospitalized hemato-oncological patients: randomized controlled trial
    Mical Paul
    Unit of Infectious Diseases, Rabin Medical Center, Beilinson Hospital, Petach Tikva, Israel Sackler Faculty of Medicine, Tel Aviv University, Ramat Aviv, Israel
    Am J Hematol 89:243-8. 2014
    ..Patients reported similar pain and satisfaction scores in both groups. Bolus IV administration of G-CSF results in longer neutropenia duration than SC administration, with no difference in clinical or quality-of-life measures...
  13. doi request reprint Healthcare-associated vs. hospital-acquired Staphylococcus aureus bacteremia
    Jihad Bishara
    Infectious Diseases Unit, Rabin Medical Center, Beilinson Hospital, and Sackler School of Medicine, Tel Aviv University, Petah Tiqva, Israel
    Int J Infect Dis 16:e457-63. 2012
    ..To analyze clinical features and outcomes of patients with hospital-acquired (HA) and healthcare-associated (HCA) Staphylococcus aureus bacteremia...
  14. ncbi request reprint Prediction of specific pathogens in patients with sepsis: evaluation of TREAT, a computerized decision support system
    Mical Paul
    Department of Medicine E, Rabin Medical Center, Beilinson Campus, Petah Tiqva, Israel
    J Antimicrob Chemother 59:1204-7. 2007
    ..Prediction of bacterial infections and their pathogens allows for early, directed investigation and treatment. We assessed the ability of TREAT, a computerized decision support system, to predict specific pathogens...
  15. ncbi request reprint Antiviral prophylaxis in haematological patients: systematic review and meta-analysis
    Dafna Yahav
    Department of Medicine E, Rabin Medical Center, Beilinson Hospital, Sackler Faculty of Medicine, Tel Aviv University, Israel
    Eur J Cancer 45:3131-48. 2009
    ..Antiviral prophylaxis is commonly prescribed to haematological cancer patients. We conducted a systematic review and meta-analysis to quantify its overall benefit in specific clinical scenarios...
  16. ncbi request reprint Surveillance of infectious complications in hemato-oncological patients
    Ron Ram
    Institute of Hematology, Rabin Medical Center, Beilinson Campus, Petah Tikva, Israel
    Isr Med Assoc J 11:133-7. 2009
    ..Monitoring the rate of infections in individual centers that treat patients with hematological malignancies is of major importance. However, there are no uniform guidelines for infection surveillance...
  17. doi request reprint Co-trimoxazole versus vancomycin for the treatment of methicillin-resistant Staphylococcus aureus bacteraemia: a retrospective cohort study
    Elad Goldberg
    Infectious Diseases Unit, Rabin Medical Center, Beilinson Hospital, Petah Tiqva, Israel
    J Antimicrob Chemother 65:1779-83. 2010
    ..To evaluate the efficacy and safety of co-trimoxazole versus that of vancomycin in adults with methicillin-resistant Staphylococcus aureus (MRSA) bacteraemia...
  18. pmc Antibiotic prophylaxis for bacterial infections in afebrile neutropenic patients following chemotherapy
    Anat Gafter-Gvili
    Department of Medicine E, Beilinson Hospital, Rabin Medical Center, 39 Jabotinski Street, PetahTikva, 49100, Israel
    Cochrane Database Syst Rev 1:CD004386. 2012
    ..Trials have shown the efficacy of antibiotic prophylaxis in reducing the incidence of bacterial infections but not in reducing mortality rates. Our systematic review from 2006 also showed a reduction in mortality...
  19. doi request reprint The role of ¹⁸F-FDG PET/CT for the diagnosis of infections in patients with hematological malignancies and persistent febrile neutropenia
    Anat Gafter-Gvili
    Institute of Hematology, Davidoff Cancer Center, Rabin Medical Center, Beilinson Hospital, Petah Tikva, Israel
    Leuk Res 37:1057-62. 2013
    ..PET/CT was beneficial in diagnosing abdominal infections. PET/CT has a potential role in the diagnostic evaluation of patients with persistent febrile neutropenia. ..
  20. pmc Thrombocytopenia in Staphylococcus aureus bacteremia: risk factors and prognostic importance
    Anat Gafter-Gvili
    Department of Medicine E, Rabin Medical Center, Beilinson Hospital, Petah Tikva 49100, Israel
    Mayo Clin Proc 86:389-96. 2011
    ..To identify risk factors and outcomes associated with thrombocytopenia at sepsis onset in Staphylococcus aureus bacteremia...
  21. ncbi request reprint Anti-pseudomonal beta-lactams for the initial, empirical, treatment of febrile neutropenia: comparison of beta-lactams
    Mical Paul
    Infectious Diseases Unit, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel, 49100
    Cochrane Database Syst Rev 11:CD005197. 2010
    ..Several beta-lactams are recommended as single agents for the treatment of febrile neutropenia...
  22. ncbi request reprint Improving empirical antibiotic treatment using TREAT, a computerized decision support system: cluster randomized trial
    Mical Paul
    Department of Medicine E, Rabin Medical Center, Beilinson Campus, 49100 Petah Tiqva, Israel
    J Antimicrob Chemother 58:1238-45. 2006
    ..Appropriate antibiotic treatment decreases mortality, while superfluous treatment is associated with antibiotic resistance. We built a computerized decision support system for antibiotic treatment (TREAT) targeting these outcomes...
  23. ncbi request reprint [Variability of management for patients hospitalized with 2009 A/H1N1 influenza in three Israeli hospitals]
    Vered Hiba
    Unit of Infectious Diseases, Rabin Medical Center, Beilinson Hospital, Petah Tikva, Israel
    Harefuah 152:524-8, 564. 2013
    ..To assess uniformity of criteria for hospitalization and management of inpatients with documented 2009 A/H1N1 influenza, at a time when national guidelines for management were issued by the public health authorities...
  24. ncbi request reprint Efficacy and safety of aminoglycoside monotherapy: systematic review and meta-analysis of randomized controlled trials
    Liat Vidal
    Department of Internal Medicine E, Rabin Medical Center, Beilinson Campus, Petah Tikva 49100, Israel
    J Antimicrob Chemother 60:247-57. 2007
    ..This study sought to compare the efficacy and adverse effects of any aminoglycoside as a single antibiotic with other antibiotics for the treatment of patients with infection...
  25. ncbi request reprint Infection-control interventions for cancer patients after chemotherapy: a systematic review and meta-analysis
    Agata Schlesinger
    Department of Medicine E, Rabin Medical Center, Beilinson Campus, Petah Tikva, Israel
    Lancet Infect Dis 9:97-107. 2009
    ..72 [95% CI 0.55-0.95]. We conclude that prophylactic antibiotics are the most effective treatment within the protective environment. Randomised trials on outpatient management of haematological cancer patients are needed...
  26. doi request reprint Does sex affect 30-day mortality in Staphylococcus aureus bacteremia?
    Nariman Mansur
    Pharmacy Services, Rabin Medical Center, Beilinson Hospital, and Sackler School of Medicine, Tel Aviv University, Petah Tiqva, Israel
    Gend Med 9:463-70. 2012
    ..Sex-related differences in complications and mortality of infection were examined with conflicting results. Further studies are required to bring new light in this topic in Staphylococcus aureus infections...
  27. ncbi request reprint The TREAT project: decision support and prediction using causal probabilistic networks
    Leonard Leibovici
    Department of Medicine E, Rabin Medical Center, Beilinson Campus, Petah Tiqva, Israel
    Int J Antimicrob Agents 30:S93-102. 2007
    ..In the present review we discuss the advantages of using causal probabilistic models for prediction and decision support, and the various decisions that were taken in the TREAT project...
  28. ncbi request reprint Antibiotic prophylaxis in neutropenic patients
    Anat Gafter-Gvili
    Department of Medicine E, Rabin Medical Center Beilinson Campus, Petah Tikva, Israel
    Isr Med Assoc J 9:460-2. 2007
  29. ncbi request reprint Elevation of CRP precedes clinical suspicion of bloodstream infections in patients undergoing hematopoietic cell transplantation
    Ron Ram
    BMT Unit, Institute of Hematology, Davidoff Cancer Center, Beilinson Hospital, Rabin Medical Center, Petah Tiqva, Israel
    J Infect 67:194-8. 2013
    ..We aimed to examine whether C-reactive protein (CRP) elevation precedes the clinical signs and symptoms of infection among patients undergoing allogeneic hematopoietic cell transplantation (HCT)...
  30. ncbi request reprint Antibiotic prophylaxis in neutropenic patients: new evidence, practical decisions
    Leonard Leibovici
    Department of Medicine E, Beilinson Campus, Rabin Medical Center, Petah Tiqva, Israel
    Cancer 107:1743-51. 2006
    ..Excessive local levels of resistance to fluoroquinolones or high local incidence of infections caused by Clostridium difficile and related to fluoroquinolones should prompt a reconsideration of this policy...
  31. ncbi request reprint Influenza vaccines in immunosuppressed adults with cancer
    Noa Eliakim-Raz
    Department of Medicine E, Beilinson Hospital, Rabin Medical Center, 39 Jabotinski Street, Petah Tikva, Israel, 49100
    Cochrane Database Syst Rev 10:CD008983. 2013
    ..Guidelines, therefore, recommend influenza vaccination for these patients. However, data on vaccine effectiveness in this population is lacking, and the value of vaccination in this population remains unclear...
  32. doi request reprint Empiric antibiotic coverage of atypical pathogens for community-acquired pneumonia in hospitalized adults
    Noa Eliakim-Raz
    Department of Medicine E, Beilinson Hospital, Rabin Medical Center, Petah Tikva, Israel
    Cochrane Database Syst Rev 9:CD004418. 2012
    ..To date, no sufficient evidence exists to support this broad coverage, while limiting coverage is bound to reduce toxicity, resistance and expense...
  33. doi request reprint Colony-stimulating factors for prevention and treatment of infectious complications in patients with acute myelogenous leukemia
    Ronit Gurion
    Institute of Hematology, Davidoff Center, Beilinson Hospital, Rabin Medical Center, Petah Tikva, Israel
    Cochrane Database Syst Rev 6:CD008238. 2012
    ..However, their safety with regard to disease-related outcomes and survival in AML is unclear. Therefore, we performed a systematic review and meta-analysis to evaluate the impact of CSFs on patient outcomes, including survival...
  34. doi request reprint Antibiotic prophylaxis in cardiac surgery: systematic review and meta-analysis
    Adi Lador
    Medicine E, Rabin Medical Center, Beilinson Hospital, Petah Tikva, Israel
    J Antimicrob Chemother 67:541-50. 2012
    ..Antibiotic prophylaxis is recommended in cardiac surgery. Current debate concerns the type of antibiotic(s), dosing and the duration of prophylaxis...
  35. doi request reprint Empirical antifungal therapy for patients with neutropenia and persistent fever: Systematic review and meta-analysis
    Elad Goldberg
    Department of Medicine E, Rabin Medical Center, Beilinson Campus, 49100 Petah Tiqva, Israel
    Eur J Cancer 44:2192-203. 2008
    ..To assess the evidence for the current standard of practice of using empirical antifungal treatment in febrile neutropenic cancer patients...
  36. pmc Hematopoietic growth factors in aplastic anemia patients treated with immunosuppressive therapy-systematic review and meta-analysis
    Ronit Gurion
    Institute of Hematology, Davidoff Center, Beilinson Hospital, Rabin Medical Center, Petah Tikva, Israel
    Haematologica 94:712-9. 2009
    ..Therefore, it should not be recommended routinely as an adjunct to the immunosuppressive therapy for patients with aplastic anemia...
  37. pmc Treatment of human brucellosis: systematic review and meta-analysis of randomised controlled trials
    Keren Skalsky
    Internal Medicine E, Rabin Medical Center, Beilinson Hospital, Petah Tikva 49100, Israel
    BMJ 336:701-4. 2008
    ..To determine and quantify differences in efficacy between treatment regimens for brucellosis...
  38. ncbi request reprint Colony-stimulating factors for prevention and treatment of infectious complications in patients with acute myelogenous leukemia
    Ronit Gurion
    Institute of Hematology, Davidoff Center, Beilinson Hospital, Rabin Medical Center, 39 Jabotinski Street, Petah Tikva, Israel, 49100
    Cochrane Database Syst Rev 9:CD008238. 2011
    ..However, their safety with regard to disease-related outcomes and survival in AML is unclear. Therefore, we performed a systematic review and meta-analysis to evaluate the impact of CSFs on patient outcomes, including survival...
  39. ncbi request reprint Clinical effectiveness of seasonal influenza vaccine among adult cancer patients
    Inbal Vinograd
    Pharmacy Services, Schneider Children s Medical Center, Petah Tikva, Israel Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    Cancer 119:4028-35. 2013
    ..Patients with cancer are at increased risk of developing complications of influenza. In this study, the authors assessed the effectiveness of influenza vaccination among cancer patients...
  40. doi request reprint ATG plus cyclosporine reduces all-cause mortality in patients with severe aplastic anemia--systematic review and meta-analysis
    Anat Gafter-Gvili
    Institute of Hematology, Davidoff Center, Rabin Medical Center, Beilinson Hospital, Petah Tiqva, Israel
    Acta Haematol 120:237-43. 2008
    ..Immunosuppression is the therapeutic alternative for patients with aplastic anemia who are ineligible for allogeneic transplant. We aimed to assess the benefit of the combination of antithymocyte globulin (ATG) and cyclosporine (CsA)...
  41. doi request reprint Immunoglobulin prophylaxis in hematopoietic stem cell transplantation: systematic review and meta-analysis
    Pia Raanani
    Institute of Hematology, Davidoff Cancer Center, Rabin Medical Center, Beilinson Hospital, Petah Tikva, Israel
    J Clin Oncol 27:770-81. 2009
    ....
  42. ncbi request reprint Effect of quinolone prophylaxis in afebrile neutropenic patients on microbial resistance: systematic review and meta-analysis
    Anat Gafter-Gvili
    Department of Medicine E, Beilinson Campus, Rabin Medical Center, Petah Tiqva, Israel
    J Antimicrob Chemother 59:5-22. 2007
    ..To assess the effect of quinolone prophylaxis following chemotherapy for malignancies on the emergence of resistant bacteria in neutropenic patients...
  43. ncbi request reprint Efficacy and safety of cefepime: a systematic review and meta-analysis
    Dafna Yahav
    Department of Medicine E, Rabin Medical Center, Petah Tiqva, Israel
    Lancet Infect Dis 7:338-48. 2007
    ..This Review provides evidence and offers possible explanations for increased mortality among patients treated with cefepime in randomised trials...
  44. doi request reprint Management of adult patients with acute lymphoblastic leukemia in first complete remission: systematic review and meta-analysis
    Ron Ram
    Institute of Hematology, Davidoff Center, Rabin Medical Center, Beilinson Hospital, Petah Tikva, Israel
    Cancer 116:3447-57. 2010
    ..The objective of this study was to compare the various potential therapeutic options for patients who achieved first complete remission...
  45. ncbi request reprint Prediction of bacteremia using TREAT, a computerized decision-support system
    Mical Paul
    Department of Medicine E, Rabin Medical Center, Beilinson Campus, Petah Tikva, Israel
    Clin Infect Dis 42:1274-82. 2006
    ..Prediction of bloodstream infection at the time of sepsis onset allows one to make appropriate and economical management decisions...
  46. ncbi request reprint Empirical antibiotics targeting Gram-positive bacteria for the treatment of febrile neutropenic patients with cancer
    Mical Paul
    Unit of Infectious Diseases, Rambam Health Care Center, Haifa, Israel and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel, 49100
    Cochrane Database Syst Rev 1:CD003914. 2014
    ..Some of these Gram-positive bacteria are increasingly resistant to beta-lactams and necessitate specific antibiotic treatment...
  47. ncbi request reprint Meta-analysis: antibiotic prophylaxis reduces mortality in neutropenic patients
    Anat Gafter-Gvili
    Rabin Medical Center, Petah Tiqva, Israel
    Ann Intern Med 142:979-95. 2005
    ..Trials have shown the efficacy of antibiotic prophylaxis in decreasing the incidence of bacterial infections but not in reducing mortality rates...
  48. ncbi request reprint Empirical antibiotic monotherapy for febrile neutropenia: systematic review and meta-analysis of randomized controlled trials
    Mical Paul
    Department of Medicine E, Rabin Medical Center, Beilinson Campus, 49100 Petah Tiqva, Israel
    J Antimicrob Chemother 57:176-89. 2006
    ..Early, empirical broad-spectrum antibiotic treatment is the established practice for febrile neutropenia. Several beta-lactams are accepted for monotherapy. We asked whether patients' outcomes are influenced by the chosen beta-lactam...
  49. doi request reprint Oral versus intravenous antibiotic treatment for febrile neutropenia in cancer patients
    Liat Vidal
    Department of Medicine E, Beilinson Hospital, Rabin Medical Center, 39 Jabotinski Street, Petah Tikva, Israel, 49100
    Cochrane Database Syst Rev 10:CD003992. 2013
    ..The common practice is to admit the patient to hospital and treat him or her empirically with intravenous broad-spectrum antibiotics. Oral therapy could be an alternative approach for selected patients...
  50. ncbi request reprint Intravenous versus oral iron supplementation for the treatment of anemia in CKD: systematic review and meta-analysis
    Benaya Rozen-Zvi
    Department of Nephrology and Hypertension, Rabin Medical Center, Beilinson Hospital, Petah Tikva, and Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
    Am J Kidney Dis 52:897-906. 2008
    ..Iron supplementation is essential for the treatment of patients with anemia of chronic kidney disease (CKD). It is not clear which is the best method of iron administration...
  51. pmc Diagnostic accuracy of PCR alone compared to galactomannan in bronchoalveolar lavage fluid for diagnosis of invasive pulmonary aspergillosis: a systematic review
    Tomer Avni
    Medicine E, Rabin Medical Center, Beilinson Hospital, Petah Tikva, Israel
    J Clin Microbiol 50:3652-8. 2012
    ..Performing both tests results in optimal sensitivity with no loss of specificity. Results are dependent on the reference standard definitions...
  52. pmc Has the time for first-line treatment with second generation tyrosine kinase inhibitors in patients with chronic myelogenous leukemia already come? Systematic review and meta-analysis
    Ronit Gurion
    Institute of Hematology, Davidoff Cancer Center, Rabin Medical Center, Tel Aviv University, Israel
    Haematologica 98:95-102. 2013
    ..Although an advantage is suggested by surrogate parameters, longer follow up is necessary to see if this translates into superior overall survival...
  53. ncbi request reprint Antifungal prophylaxis in cancer patients after chemotherapy or hematopoietic stem-cell transplantation: systematic review and meta-analysis
    Eyal Robenshtok
    Department of Medicine E, Rabin Medical Center, Petah Tiqva, Israel
    J Clin Oncol 25:5471-89. 2007
    ..Many studies have evaluated the role of antifungal prophylaxis in cancer patients, with inconsistent conclusions...
  54. ncbi request reprint Treatment of invasive candidal infections: systematic review and meta-analysis
    Anat Gafter-Gvili
    Department of Hematology, Davidoff Cancer Center, Rabin Medical Center, Beilinson Campus, 49100 Petah Tiqva, Israel
    Mayo Clin Proc 83:1011-21. 2008
    ..To compare available antifungal treatments for invasive candidiasis, a leading cause of nosocomial bloodstream infections...
  55. pmc Co-trimoxazole-sensitive, methicillin-resistant Staphylococcus aureus, Israel, 1988-1997
    Jihad Bishara
    Department of Internal Medicine C, Rabin Medical Center, Beilinson Campus, Petach Tikvah, Israel
    Emerg Infect Dis 9:1168-9. 2003
    ..0001). If also observed in other institutions, these findings should encourage the performance of a clinical trial of sufficient size to compare co-trimoxazole to vancomycin in treating MRSA infections...
  56. pmc Systematic review and meta-analysis of in vitro synergy of polymyxins and carbapenems
    Oren Zusman
    Department of Medicine E, Rabin Medical Center, Petah Tiqva, Israel
    Antimicrob Agents Chemother 57:5104-11. 2013
    ..baumannii, is supported in vitro by high synergy rates, with low antagonism and less resistance development. These findings should be examined in clinical studies. ..
  57. ncbi request reprint Beta lactam antibiotic monotherapy versus beta lactam-aminoglycoside antibiotic combination therapy for sepsis
    Mical Paul
    Division of Infectious Diseases, Rambam Health Care Campus and the Technion Israel Institute of Technology, 6 Ha Aliya Street, Haifa, Israel, 31096
    Cochrane Database Syst Rev 1:CD003344. 2014
    ..Optimal antibiotic treatment for sepsis is imperative. Combining a beta lactam antibiotic with an aminoglycoside antibiotic may provide certain advantages over beta lactam monotherapy...
  58. ncbi request reprint Oral versus intravenous antibiotic treatment for febrile neutropenia in cancer patients: a systematic review and meta-analysis of randomized trials
    Liat Vidal
    Department of Medicine E, Beilinson Campus, Rabin Medical Center, Petah Tiqva 49100
    J Antimicrob Chemother 54:29-37. 2004
    ..Oral therapy could be an alternative approach for selected patients...
  59. doi request reprint Antibiotics for preventing meningococcal infections
    Anca Zalmanovici Trestioreanu
    Department of Family Medicine, Beilinson Campus, Rabin Medical Center, 39 Jabotinski Street, Petah Tikva, Israel, 49100
    Cochrane Database Syst Rev 10:CD004785. 2013
    ..Prophylaxis is considered for close contacts of people with a meningococcal infection and populations with known high carriage rates...
  60. ncbi request reprint Three-day vs longer duration of antibiotic treatment for cystitis in women: systematic review and meta-analysis
    Eugene A Katchman
    Department of Medicine E, Rabin Medical Center, Beilinson Campus, Petah Tiqva, Israel
    Am J Med 118:1196-207. 2005
    ..We performed a meta-analysis to ascertain the efficacy and safety of the currently practiced 3-day antibiotic therapy for cystitis versus prolonged therapy (5 days or longer) to relieve symptoms and to achieve bacteriological cure...
  61. ncbi request reprint Empirical antibiotics against Gram-positive infections for febrile neutropenia: systematic review and meta-analysis of randomized controlled trials
    Mical Paul
    Department of Medicine E, Rabin Medical Center, Beilinson Campus, 49100 Petah Tiqva
    J Antimicrob Chemother 55:436-44. 2005
    ..To assess the value of empirical anti-Gram-positive antibiotics for the treatment of febrile neutropenia...
  62. doi request reprint Aminoglycoside drugs in clinical practice: an evidence-based approach
    Leonard Leibovici
    Department of Medicine E, Beilinson Campus, Petah Tiqva 49100, Israel
    J Antimicrob Chemother 63:246-51. 2009
    ..They probably induce less resistance. Pragmatic large trials are needed to answer open clinical questions on the use of aminoglycosides...
  63. doi request reprint Duration of antibiotic treatment for acute pyelonephritis and septic urinary tract infection-- 7 days or less versus longer treatment: systematic review and meta-analysis of randomized controlled trials
    Noa Eliakim-Raz
    Department of Medicine E, Rabin Medical Center, Beilinson Hospital, Petah Tiqva, Israel
    J Antimicrob Chemother 68:2183-91. 2013
    ..Acute pyelonephritis is a frequent cause of morbidity, with a wide variation in duration of therapy. We performed a systematic review of all randomized controlled trials (RCTs) comparing ≤7 days treatment with a longer course...
  64. doi request reprint Time to first antibiotic dose for patients hospitalised with community-acquired pneumonia
    Dafna Yahav
    Department of Medicine E, Rabin Medical Center, Beilinson Hospital, Petah Tiqva, Israel
    Int J Antimicrob Agents 41:410-3. 2013
    ..We believe that attention should be shifted to early appropriate empirical antibiotic treatment for severe sepsis in hospital regardless of the source of infection, rather than focusing on CAP...
  65. doi request reprint Duration of antibiotic prophylaxis for cardiac surgery: prospective observational study
    Mical Paul
    Unit of Infectious Diseases, Rabin Medical Center, Beilinson Hospital and Sackler Faculty of Medicine, Tel Aviv University, Petah Tikva, Israel
    J Infect 58:291-8. 2009
    ..To assess the effect of prolonging antibiotic prophylaxis in cardiac surgery...
  66. ncbi request reprint Antimicrobial lock solutions for the prevention of infections associated with intravascular catheters in patients undergoing hemodialysis: systematic review and meta-analysis of randomized, controlled trials
    Dafna Yahav
    Department of Medicine E, Rabin Medical Center, Beilinson Campus, 49100 Petah Tiqva, Israel
    Clin Infect Dis 47:83-93. 2008
    ..Prevention of catheter-related bloodstream infections in patients undergoing hemodialysis by use of antimicrobial catheter lock solutions has been examined in several trials, but no consensus is available for clinical practice...
  67. ncbi request reprint Aminoglycoside/beta-lactam combinations in clinical practice
    Leonard Leibovici
    Department of Medicine E, Beilinson Campus, Petah Tiqva 49100, Israel
    J Antimicrob Chemother 60:911-2. 2007
    ....
  68. doi request reprint Anthracycline-containing regimens for treatment of follicular lymphoma in adults
    Gilad Itchaki
    Institute of Hematology, Davidoff Center, Beilinson Hospital, Rabin Medical Center, Petah Tikva, Israel
    Cochrane Database Syst Rev 7:CD008909. 2013
    ..However, there is no proof that they are superior to non-anthracycline-containing regimens (non-ACR)...
  69. ncbi request reprint Prophylaxis of Pneumocystis pneumonia in immunocompromised non-HIV-infected patients: systematic review and meta-analysis of randomized controlled trials
    Hefziba Green
    Unit of Infectious Diseases, Rabin Medical Centre, Beilison Hospital, Petah Tikva 49100, Israel
    Mayo Clin Proc 82:1052-9. 2007
    ..To assess the efficacy of prophylaxis for Pneumocystis pneumonia (PCP), caused by Pneumocystis jirovecii (formerly Pneumocystis carinii), for immunocompromised non-HIV-infected patients by conducting a systematic review and meta-analysis...
  70. doi request reprint Benefit of early treatment with oseltamivir in hospitalized patients with documented 2009 influenza A (H1N1): retrospective cohort study
    Vered Hiba
    School of Public Health, Tel Aviv University, Ramat Aviv, Israel
    J Antimicrob Chemother 66:1150-5. 2011
    ..We assessed the association between early oseltamivir treatment and influenza complications in hospitalized patients...
  71. ncbi request reprint Selective low-dose valganciclovir for prevention of cytomegalovirus disease following kidney transplantation
    Yafit Partouche Avidan
    Department of Transplantation, Rabin Medical Center, Beilinson Hospital, Tel Aviv University, Sackler Faculty of Medicine, Tel Aviv, Israel
    J Infect 57:236-40. 2008
    ..To assess the safety of a cytomegalovirus prophylaxis regimen using selective low-dose valganciclovir...
  72. pmc Comparative efficacy and safety of vancomycin versus teicoplanin: systematic review and meta-analysis
    Shuli Svetitsky
    Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    Antimicrob Agents Chemother 53:4069-79. 2009
    ..44; 95% CI, 0.32 to 0.61), and red man syndrome were significantly less frequent with teicoplanin. Teicoplanin is not inferior to vancomycin with regard to efficacy and is associated with a lower adverse event rate than vancomycin...
  73. doi request reprint A model for diagnosis of pulmonary infections in solid-organ transplant recipients
    Galia Kariv
    Rabin Medical Center, Petach Tikva, Israel
    Comput Methods Programs Biomed 104:135-42. 2011
    ..Treatment directed at the offending organism started as soon as possible improves survival...
  74. ncbi request reprint Empirical atypical coverage for inpatients with community-acquired pneumonia: systematic review of randomized controlled trials
    Daphna Shefet
    Department of Medicine E, Beilinson Campus, Rabin Medical Center, Petah Tiqva, Israel
    Arch Intern Med 165:1992-2000. 2005
    ..Our goal was to assess the efficacy of empirical coverage of atypical pathogens in terms of mortality and clinical and bacteriological success...
  75. ncbi request reprint Sternal wound infection after coronary artery bypass graft surgery: validation of existing risk scores
    Mical Paul
    Department of Internal Medicine E, Rabin Medical Center, Beilinson Hospital and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    J Thorac Cardiovasc Surg 133:397-403. 2007
    ..Prediction of surgical site infection and mortality after cardiac surgery might allow for interventions to reduce adverse outcomes. We sought to evaluate existing risk scores...
  76. ncbi request reprint Appropriateness of antibiotic therapy on weekends versus weekdays
    Jihad Bishara
    Infectious Diseases Unit, Rabin Medical Center, Beilinson Hospital, Petah Tiqwa 49100, Israel
    J Antimicrob Chemother 60:625-8. 2007
    ..To compare the appropriateness of antibiotic treatment prescribed in an emergency department (ED) of a tertiary medical centre on weekdays and weekends...
  77. pmc PCR diagnosis of invasive candidiasis: systematic review and meta-analysis
    Tomer Avni
    Medicine E, Rabin Medical Center, Beilinson Hospital, Petah Tikva 49100, Israel
    J Clin Microbiol 49:665-70. 2011
    ..Its effects on clinical outcomes should be investigated...
  78. doi request reprint Combination antimicrobial treatment versus monotherapy: the contribution of meta-analyses
    Mical Paul
    Unit of Infectious Diseases, Rabin Medical Center, Beilinson Campus, Petah Tikva, Israel
    Infect Dis Clin North Am 23:277-93. 2009
    ....
  79. ncbi request reprint Efficacy and safety of tigecycline: a systematic review and meta-analysis
    Dafna Yahav
    Department of Medicine E, Rabin Medical Center, Beilinson Hospital, Petah Tiqva, Israel
    J Antimicrob Chemother 66:1963-71. 2011
    ..Tigecycline is a novel glycylcycline that exhibits broad-spectrum antibacterial activity. Recently, the US FDA issued a warning concerning increased mortality with tigecycline in randomized controlled trials (RCTs)...
  80. doi request reprint Immunoglobulin prophylaxis in chronic lymphocytic leukemia and multiple myeloma: systematic review and meta-analysis
    Pia Raanani
    Institute of Hematology, Davidoff Cancer Center, Rabin Medical Center, Beilinson Hospital, Petah Tikva, Israel
    Leuk Lymphoma 50:764-72. 2009
    ..On the basis of the available data, IVIG cannot be recommended routinely for patients with CLL or MM with hypogammaglobulinemia and/or recurrent infections and should be considered on individual basis...
  81. pmc Assessing ethics of trials in systematic reviews
    Michael A Weingarten
    Department of Family Medicine, Tel Aviv University, Tel Aviv, Israel
    BMJ 328:1013-4. 2004
  82. ncbi request reprint [The clinician-scientist: proposal for a new paradigm]
    Leonard Leibovici
    Department of Medicine E, Beilinson Tiqva
    Harefuah 149:661-4, 683. 2010
    ..The clinician-scientist should perform medical research. Investing in this paradigm wilt encourage young doctors to conduct research directly oriented to benefit their patients...
  83. pmc PCR using blood for diagnosis of invasive pneumococcal disease: systematic review and meta-analysis
    Tomer Avni
    Department of Medicine E, Rabin Medical Center, Belinson Hospital, Ramat Aviv, Israel
    J Clin Microbiol 48:489-96. 2010
    ..Currently available methods for PCR with blood samples for the diagnosis of IPD lack the sensitivity and specificity necessary for clinical practice...
  84. doi request reprint Clinical implications of β-lactam-aminoglycoside synergism: systematic review of randomised trials
    Ronit Marcus
    Medicine E, Rabin Medical Center, Beilinson Hospital and Sackler Faculty of Medicine, Tel Aviv University, Israel
    Int J Antimicrob Agents 37:491-503. 2011
    ..Overall, no clinical benefit was found for the use of a β-lactam with an aminoglycoside compared with a β-lactam alone. Treatment with β-lactams as monotherapy entailed more antibiotic regimen modifications in open trials...
  85. ncbi request reprint Combination antibiotic therapy for Pseudomonas aeruginosa bacteraemia
    Mical Paul
    Department of Internal Medicine E, Rabin Medical Centre, Beilinson Campus, Petach Tikva, Israel
    Lancet Infect Dis 5:192-3; discussion 193-4. 2005
  86. doi request reprint Ethical dilemmas in antibiotic treatment
    Leonard Leibovici
    Department of Medicine E, Beilinson Hospital, Rabin Medical Center, Petah Tiqva, Israel
    J Antimicrob Chemother 67:12-6. 2012
    ..None of these solve the problem of patients' autonomy. We see no other way but to argue that the right of future patients to come to less harm outweighs the right of the present patient to share in decisions on antibiotic treatment...
  87. ncbi request reprint Considering resistance in systematic reviews of antibiotic treatment
    Leonard Leibovici
    Department of Medicine E, Beilinson Campus, Rabin Medical Center, Petah Tiqva 49100, Israel
    J Antimicrob Chemother 52:564-71. 2003
    ..Systematic reviews on antibiotic drugs that ignore the topic of resistance present readers with a skewed view, emphasizing short-term efficacy or effectiveness while ignoring long-term consequences...
  88. doi request reprint Reporting of adverse events in randomized controlled trials of highly active antiretroviral therapy: systematic review
    Michal Y Chowers
    Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    J Antimicrob Chemother 64:239-50. 2009
    ....
  89. pmc Systematic comparison of four sources of drug information regarding adjustment of dose for renal function
    Liat Vidal
    Department of Medicine E, Beilinson Campus, Rabin Medical Center, Petah Tiqva, Israel
    BMJ 331:263. 2005
    ..To compare advice on dosage adjustment for renal impairment provided by four commonly used secondary pharmacotherapeutic sources...