Jonathan Leor

Summary

Affiliation: Tel Aviv University
Country: Israel

Publications

  1. ncbi request reprint Reprogramming cells for transplantation
    Jonathan Leor
    Neufeld Cardiac Research Institute, Sheba Medical Center, Tel Hashomer, Israel
    Heart Fail Rev 8:285-92. 2003
  2. ncbi request reprint Cells, scaffolds, and molecules for myocardial tissue engineering
    Jonathan Leor
    Neufeld Cardiac Research Institute, Tel Aviv University, Sheba Medical Center, Tel Hashomer 52621, Israel
    Pharmacol Ther 105:151-63. 2005
  3. ncbi request reprint Cell transplantation and genetic engineering: new approaches to cardiac pathology
    Jonathan Leor
    Neufeld Cardiac Research Institute, Tel Aviv University, Sheba Medical Center, Tel Hashomer 52621, Israel
    Expert Opin Biol Ther 3:1023-39. 2003
  4. ncbi request reprint Human umbilical cord blood-derived CD133+ cells enhance function and repair of the infarcted myocardium
    Jonathan Leor
    Neufeld Cardiac Research Institute, Sheba Medical Center, Tel Aviv University, Tel Hashomer, Israel
    Stem Cells 24:772-80. 2006
  5. ncbi request reprint Myocardial tissue engineering: creating a muscle patch for a wounded heart
    Jonathan Leor
    Neufeld Cardiac Research Institute, Tel Aviv University, Sheba Medical Center, Tel Hashomer 52621, Israel
    Ann N Y Acad Sci 1015:312-9. 2004
  6. ncbi request reprint Renovation of the injured heart with myocardial tissue engineering
    Jonathan Leor
    Sheba Medical Center, Neufeld Cardiac Research Institute, Tel Aviv University, Tel Hashomer 52621, Israel
    Expert Rev Cardiovasc Ther 4:239-52. 2006
  7. doi request reprint Intracoronary injection of in situ forming alginate hydrogel reverses left ventricular remodeling after myocardial infarction in Swine
    Jonathan Leor
    Neufeld Cardiac Research Institute, Sheba Medical Center, Tel Aviv University, Tel Hashomer 52621, Israel
    J Am Coll Cardiol 54:1014-23. 2009
  8. pmc Human embryonic stem cell transplantation to repair the infarcted myocardium
    Jonathan Leor
    Neufeld Cardiac Research Institute, Sheba Medical Centre, Tel Aviv University, Tel Hashomer, Israel
    Heart 93:1278-84. 2007
  9. doi request reprint Effect of injectable alginate implant on cardiac remodeling and function after recent and old infarcts in rat
    Natali Landa
    Neufeld Cardiac Research Institute, Sheba Medical Center, Tel Aviv University, Tel Hashomer 52621, Israel
    Circulation 117:1388-96. 2008
  10. ncbi request reprint Underuse of standard care and outcome of patients with acute myocardial infarction and chronic renal insufficiency
    Ariel Tessone
    Neufeld Cardiac Research Institute, Tel Aviv University, Tel Hashomer, Israel
    Cardiology 108:193-9. 2007

Detail Information

Publications61

  1. ncbi request reprint Reprogramming cells for transplantation
    Jonathan Leor
    Neufeld Cardiac Research Institute, Sheba Medical Center, Tel Hashomer, Israel
    Heart Fail Rev 8:285-92. 2003
    ....
  2. ncbi request reprint Cells, scaffolds, and molecules for myocardial tissue engineering
    Jonathan Leor
    Neufeld Cardiac Research Institute, Tel Aviv University, Sheba Medical Center, Tel Hashomer 52621, Israel
    Pharmacol Ther 105:151-63. 2005
    ..The purpose of our review is to describe the principles, status, and challenges of myocardial tissue engineering with emphasize on the concept of in situ cardiac tissue engineering and regeneration...
  3. ncbi request reprint Cell transplantation and genetic engineering: new approaches to cardiac pathology
    Jonathan Leor
    Neufeld Cardiac Research Institute, Tel Aviv University, Sheba Medical Center, Tel Hashomer 52621, Israel
    Expert Opin Biol Ther 3:1023-39. 2003
    ..The present review will focus on selected topics related to the promise and obstacles associated with cell transplantation, with and without genetic manipulation, for myocardial repair...
  4. ncbi request reprint Human umbilical cord blood-derived CD133+ cells enhance function and repair of the infarcted myocardium
    Jonathan Leor
    Neufeld Cardiac Research Institute, Sheba Medical Center, Tel Aviv University, Tel Hashomer, Israel
    Stem Cells 24:772-80. 2006
    ..In conclusion, the present work suggests that, after MI, intravenous delivery of human UCB-derived CD133+ cells can produce functional recovery by preventing scar thinning and LV systolic dilatation...
  5. ncbi request reprint Myocardial tissue engineering: creating a muscle patch for a wounded heart
    Jonathan Leor
    Neufeld Cardiac Research Institute, Tel Aviv University, Sheba Medical Center, Tel Hashomer 52621, Israel
    Ann N Y Acad Sci 1015:312-9. 2004
    ..Here, we present an up-to-date summary of research studies in cardiac tissue engineering, with an emphasis on the critical design principles...
  6. ncbi request reprint Renovation of the injured heart with myocardial tissue engineering
    Jonathan Leor
    Sheba Medical Center, Neufeld Cardiac Research Institute, Tel Aviv University, Tel Hashomer 52621, Israel
    Expert Rev Cardiovasc Ther 4:239-52. 2006
    ..In addition, the new strategy of in situ and injectable tissue engineering for myocardial repair and regeneration is presented...
  7. doi request reprint Intracoronary injection of in situ forming alginate hydrogel reverses left ventricular remodeling after myocardial infarction in Swine
    Jonathan Leor
    Neufeld Cardiac Research Institute, Sheba Medical Center, Tel Aviv University, Tel Hashomer 52621, Israel
    J Am Coll Cardiol 54:1014-23. 2009
    ..This study sought to determine whether alginate biomaterial can be delivered effectively into the infarcted myocardium by intracoronary injection to prevent left ventricular (LV) remodeling early after myocardial infarction (MI)...
  8. pmc Human embryonic stem cell transplantation to repair the infarcted myocardium
    Jonathan Leor
    Neufeld Cardiac Research Institute, Sheba Medical Centre, Tel Aviv University, Tel Hashomer, Israel
    Heart 93:1278-84. 2007
    ....
  9. doi request reprint Effect of injectable alginate implant on cardiac remodeling and function after recent and old infarcts in rat
    Natali Landa
    Neufeld Cardiac Research Institute, Sheba Medical Center, Tel Aviv University, Tel Hashomer 52621, Israel
    Circulation 117:1388-96. 2008
    ..We hypothesized that injection of in situ-forming alginate hydrogel into recent and old infarcts would provide a temporary scaffold and attenuate adverse cardiac remodeling and dysfunction...
  10. ncbi request reprint Underuse of standard care and outcome of patients with acute myocardial infarction and chronic renal insufficiency
    Ariel Tessone
    Neufeld Cardiac Research Institute, Tel Aviv University, Tel Hashomer, Israel
    Cardiology 108:193-9. 2007
    ..To investigate characteristics, management and outcome of patients with acute myocardial infarction (AMI) and chronic renal insufficiency (CRI)...
  11. doi request reprint Evaluation of a peritoneal-generated cardiac patch in a rat model of heterotopic heart transplantation
    Gabriel Amir
    Neufeld Cardiac Research Institute, Sheba Medical Center, Tel Aviv University, Tel Hashomer, Israel
    Cell Transplant 18:275-82. 2009
    ..Our study also offers a viable rat model for screening and evaluating new concepts in cardiac reconstruction and engineering...
  12. doi request reprint Patient characteristics and cell source determine the number of isolated human cardiac progenitor cells
    Ayelet Itzhaki-Alfia
    Neufeld Cardiac Research Institute, Sheba Medical Center, Tel Hashomer, Israel
    Circulation 120:2559-66. 2009
    ..Using a novel method to isolate human cardiac progenitor cells, we aimed to define the optimal source and association between their number and patient characteristics...
  13. ncbi request reprint Functional capacity impairment in patients with coronary artery disease: prevalence, risk factors and prognosis
    Alexander Tenenbaum
    Cardiac Rehabilitation Institute, Chaim Sheba Medical Center, Tel Hashomer 52621, Israel
    Cardiology 100:207-15. 2003
    ..The present study was aimed to evaluate the outcome of CAD-related functional capacity impairment in patients with and without a history of MI over a 7.7-year follow-up...
  14. ncbi request reprint Systemic delivery of bone marrow-derived mesenchymal stem cells to the infarcted myocardium: feasibility, cell migration, and body distribution
    Israel M Barbash
    Neufeld Cardiac Research Institute, Sheba Medical Center, Tel Hashomer 52621, Israel
    Circulation 108:863-8. 2003
    ..Systemic delivery of bone marrow-derived mesenchymal stem cells (BM-MSCs) is an attractive approach for myocardial repair. We aimed to test this strategy in a rat model after myocardial infarction (MI)...
  15. ncbi request reprint Cellular cardiomyoplasty of cardiac fibroblasts by adenoviral delivery of MyoD ex vivo: an unlimited source of cells for myocardial repair
    Sharon Etzion
    Neufeld Cardiac Research Institute, Tel Aviv University, Sheba Medical Center, Tel Hashomer, Israel
    Circulation 106:I125-30. 2002
    ..The purpose of our study was to determine whether MyoD could induce primary cardiac fibroblasts, isolated from infarcted myocardium or pericardium, to undergo myogenic conversion in a clinically relevant approach...
  16. ncbi request reprint Refractoriness and conduction interaction during modulation of non-ischemic ventricular fibrillation by flecainide
    Giora Amitzur
    Neufeld Cardiac Research Institute, Tel Aviv University, Israel
    Cardiovasc Drugs Ther 17:237-47. 2003
    ..To study refractoriness and conduction interaction during modulation of non-ischemic ventricular fibrillation (VF) by flecainide...
  17. ncbi request reprint Iron-oxide labeling and outcome of transplanted mesenchymal stem cells in the infarcted myocardium
    Yoram Amsalem
    Neufeld Cardiac Research Institute, Sheba Medical Center, Tel Hashomer 52621, Israel
    Circulation 116:I38-45. 2007
    ..We sought to determine whether mesenchymal stem cell (MSC) outcome is affected by SPIO labeling in a rat model of myocardial infarction...
  18. ncbi request reprint Effect of bezafibrate on incidence of type 2 diabetes mellitus in obese patients
    Alexander Tenenbaum
    Cardiac Rehabilitation Institute, Chaim Sheba Medical Center, Tel Hashomer 52621, Israel
    Eur Heart J 26:2032-8. 2005
    ..To assess the effect of fibric acid derivative bezafibrate on incidence of type 2 diabetes in obese patients over a median 6.3 years follow-up period...
  19. ncbi request reprint Ex vivo activated human macrophages improve healing, remodeling, and function of the infarcted heart
    Jonathan Leor
    Neufeld Cardiac Research Institute, Tel Aviv University, Israel
    Circulation 114:I94-100. 2006
    ..Activated macrophages have a significant role in wound healing and damaged tissue repair. We sought to explore the ability of ex vivo activated macrophages to promote healing and repair of the infarcted myocardium...
  20. pmc The origin of human mesenchymal stromal cells dictates their reparative properties
    Nili Naftali-Shani
    Leviev Heart Center, Sheba Medical Center, Tamman Cardiovascular Research Institute, Tel Hashomer, Israel
    J Am Heart Assoc 2:e000253. 2013
    ..We aimed to test the hypothesis that hMSCs from the heart and epicardial fat would be better cells for infarct repair...
  21. ncbi request reprint Effect of matrix metalloproteinase inhibition by doxycycline on myocardial healing and remodeling after myocardial infarction
    Ariel Tessone
    Neufeld Cardiac Research Institute, Sheba Medical Center, Tel Aviv University, Tel Hashomer, Israel
    Cardiovasc Drugs Ther 19:383-90. 2005
    ..Our findings caution against aggressive, non-selective inhibition of MMPs in the early healing phase after MI...
  22. doi request reprint Effect of bundle branch block patterns on mortality in hospitalized patients with heart failure
    Alon Barsheshet
    Heart Institute, Sheba Medical Center, and Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
    Am J Cardiol 101:1303-8. 2008
    ..In conclusion, RBBB rather than LBBB is an independent predictor of mortality in hospitalized patients with systolic HF. This prognostic marker could be used for risk stratification and the selection of treatment...
  23. ncbi request reprint Is hypoglycaemia a marker for increased long-term mortality risk in patients with coronary artery disease? An 8-year follow-up
    Enrique Z Fisman
    Cardiac Rehabilitation Institute, Chaim Medical Center, Tel Hashomer, and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    Eur J Cardiovasc Prev Rehabil 11:135-43. 2004
    ..We aimed to investigate the relationship between hypoglycaemia and all-cause, cardiovascular and cancer mortality in a large population of patients with CAD...
  24. doi request reprint Macrophage subpopulations are essential for infarct repair with and without stem cell therapy
    Tamar Ben-Mordechai
    Neufeld Cardiac Research Institute, Tel Aviv University, Sheba Center for Regenerative Medicine, Stem Cells, and Tissue Engineering, and Tamman Cardiovascular Research Institute, Tel Aviv, Israel
    J Am Coll Cardiol 62:1890-901. 2013
    ..This study sought to investigate the hypothesis that the favorable effects of mesenchymal stromal cells (MSCs) on infarct repair are mediated by macrophages...
  25. ncbi request reprint Functional class in patients with heart failure is associated with the development of diabetes
    Alexander Tenenbaum
    Cardiac Rehabilitation Institute, Neufeld Cardiac Research Institute, The Chaim Sheba Medical Center, Tel Hashomer, 52621 Israel
    Am J Med 114:271-5. 2003
    ..We followed patients with coronary artery disease who participated in the Bezafibrate Infarction Prevention study to determine the incidence of diabetes by baseline functional status during a 7.7-year follow-up...
  26. ncbi request reprint Outcome of myocardial infarction in patients treated with aspirin is enhanced by pre-hospital administration
    Israel M Barbash
    Neufeld Cardiac Research Institute, Tel Aviv University, Sheba Medical Center, Tel Hashomer, Israel
    Cardiology 98:141-7. 2002
    ..Reducing time to reperfusion therapy is one of the goals in the management of acute myocardial infarction (AMI). We assessed the association between timing of aspirin administration and outcome of patients with AMI...
  27. ncbi request reprint Myocardial regeneration by adult stem cells
    Israel M Barbash
    Neufeld Cardiac Research Institute, Sheba Medical Center, Tel Hashomer, Israel
    Isr Med Assoc J 8:283-7. 2006
    ..The present review aims to describe the potential, the current status and the future challenges of myocardial regeneration by adult stem cells...
  28. doi request reprint Prevalence and significance of unrecognized renal insufficiency in patients with heart failure
    Yoram Amsalem
    Neufeld Cardiac Research Institute, Sheba Medical Center, Tel Aviv University, Tel Hashomer 52621, Israel
    Eur Heart J 29:1029-36. 2008
    ..Renal insufficiency (RI) is a strong predictor of adverse outcome in patients with heart failure (HF). We aimed to determine the prevalence of RI being unrecognized and its significance in patients hospitalized with HF...
  29. doi request reprint Non-invasive assessment of experimental autoimmune myocarditis in rats using a 3 T clinical MRI scanner
    Shunit Rinkevich-Shop
    Tamman Cardiovascular Research Institute, Leviev Heart Center, Sheba Medical Center, Tel Hashomer, Israel
    Eur Heart J Cardiovasc Imaging 14:1069-79. 2013
    ..The aim of this study was to assess the use of a 3 T clinical cardiac magnetic resonance (CMR) scanner to detect injury to the heart in experimental autoimmune myocarditis (EAM)...
  30. ncbi request reprint Comparison of effectiveness of angiotensin-converting enzyme inhibitors after acute myocardial infarction in diabetic versus nondiabetic patients
    Shmuel Gottlieb
    Neufeld Cardiac Research Institute Sheba Medical Center, Tel Hashomer, Israel
    Am J Cardiol 92:1020-5. 2003
    ..56 to 1.15). Thus, treatment with ACE inhibitors after AMI appears to be particularly beneficial in diabetic patients. The beneficial effect observed supports the widespread use of ACE inhibitors in diabetic patients after AMI...
  31. doi request reprint Mast cell inhibition attenuates myocardial damage, adverse remodeling, and dysfunction during fulminant myocarditis in the rat
    Yair Mina
    Neufeld Cardiac Research Institute, Sackler Faculty of Medicine, Tel Aviv University, Sheba Medical Center, Tel Hashomer, Israel
    J Cardiovasc Pharmacol Ther 18:152-61. 2013
    ..Thus, we sought to test the hypothesis that mast cell inhibition will attenuate the inflammatory reaction and associated left ventricular (LV) remodeling and dysfunction after fulminant autoimmune myocarditis. Methods and..
  32. ncbi request reprint Protocols for myocardial infarction repair using fetal cardiac myocytes
    Sharon Etzion
    Neufeld Cardiac Research Institute, Tel Aviv University, Sheba Medical Center, Tel Hashomer, Israel
    Methods Mol Med 112:205-21. 2005
    ..We describe methods of cell isolation, culture, labeling, and assessment of the influence of the engrafted cells on left ventricular remodeling and function...
  33. ncbi request reprint Evaluation of the pro-angiogenic effect of factor XIII in heterotopic mouse heart allografts and FXIII-deficient mice
    Rima Dardik
    Institute of Thrombosis and Hemostasis, Sheba Medical Center, Tel Hashomer, Israel
    Thromb Haemost 95:546-50. 2006
    ..The results of this study provide substantial in vivo evidence for the proangiogenic activity of FXIIIa...
  34. ncbi request reprint Association of elevated homocysteine levels with a higher risk of recurrent coronary events and mortality in patients with acute myocardial infarction
    Shlomi Matetzky
    Heart Institute, Sheba Medical Center, Tel Hashomer, Israel
    Arch Intern Med 163:1933-7. 2003
    ..Despite the prothrombotic and proinflammatory effects associated with elevated homocysteine levels, only limited data exist regarding the effect of homocysteine levels on outcome of patients with acute myocardial infarction...
  35. ncbi request reprint Admission blood glucose level and mortality among hospitalized nondiabetic patients with heart failure
    Alon Barsheshet
    Neufeld Cardiac Research Institute, Sheba Medical Center, Tel Hashomer 52621, Israel
    Arch Intern Med 166:1613-9. 2006
    ..We examined the possible association between admission glucose levels and outcome in a large cohort of hospitalized patients with HF...
  36. ncbi request reprint The effects of external counter pulsation therapy on circulating endothelial progenitor cells in patients with angina pectoris
    Alon Barsheshet
    Neufeld Cardiac Research Institute, Sheba Medical Center, Tel Hashomer, Israel
    Cardiology 110:160-6. 2008
    ..External counter pulsation therapy (ECPT) offers symptomatic relief and improves ischemia in patients with refractory angina pectoris. We aimed to determine the effects of ECPT on circulating endothelial progenitor cells (EPCs)...
  37. pmc Effects of a vildagliptin/metformin combination on markers of atherosclerosis, thrombosis, and inflammation in diabetic patients with coronary artery disease
    Robert Klempfner
    Cardiac Rehabilitation Institute, Leviev Heart Center, Sheba Medical Center, 52621, Tel Hashomer, Israel
    Cardiovasc Diabetol 11:60. 2012
    ..Animal evidence indicates that dipeptidyl peptidase-4 inhibitors have anti-atherosclerotic effects, yet clinical data are scarcely available...
  38. ncbi request reprint A prospective national survey of management and clinical outcome of acute myocardial infarction in Israel, 2000
    Solomon Behar
    Israel Center for Disease Control, Gertner Institute, Tel Hashomer, Israel
    Isr Med Assoc J 5:249-54. 2003
    ..Little information is available on the clinical practice and implementation of guidelines for treating acute myocardial infarction patients in Israel...
  39. ncbi request reprint Peroxisome proliferator-activated receptor ligand bezafibrate for prevention of type 2 diabetes mellitus in patients with coronary artery disease
    Alexander Tenenbaum
    Cardiac Rehabilitation Institute, Chaim Sheba Medical Center, Tel Hashomer, 52621 Israel
    Circulation 109:2197-202. 2004
    ..2-year follow-up period...
  40. ncbi request reprint The management, early and one year outcome in hospitalized patients with heart failure: a national Heart Failure Survey in Israel--HFSIS 2003
    Moshe Garty
    Recanati Center, Rabin Medical Center, Beilinson Campus, Petah Tikva, Israel
    Isr Med Assoc J 9:227-33. 2007
    ..Despite improved management of heart failure patients, their prognosis remains poor...
  41. ncbi request reprint Soluble intercellular adhesion molecule-1 and long-term risk of acute coronary events in patients with chronic coronary heart disease. Data from the Bezafibrate Infarction Prevention (BIP) Study
    Moti Haim
    Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
    J Am Coll Cardiol 39:1133-8. 2002
    ..The goal of this study was to assess soluble intercellular adhesion molecule-1 (sICAM-1) level as a predictor of future acute coronary events in patients with chronic coronary heart disease (CHD)...
  42. doi request reprint Human macrophage regulation via interaction with cardiac adipose tissue-derived mesenchymal stromal cells
    Shimrit Adutler-Lieber
    Neufeld Cardiac Research Institute, Tel Aviv University, Sheba Medical Center, Tel Hashomer, Israel
    J Cardiovasc Pharmacol Ther 18:78-86. 2013
    ..Methods and..
  43. ncbi request reprint Modulation of ventricular fibrillation in isolated perfused heart by dofetilide
    Giora Amitzur
    Neufeld Cardiac Research Institute, Sheba Medical Center, Tel Hashomer 52621, Israel
    J Cardiovasc Pharmacol 41:838-48. 2003
    ..These changes in fibrillation suggest that these effects are mainly associated with refractoriness prolongation and do not seem to be attenuated by conduction suppression...
  44. ncbi request reprint Cancer cells ablation with irreversible electroporation
    Liron Miller
    Neufeld Cardiac Research Institute, Sheba Medical Center, Tel Aviv University, Tel Hashomer, Israel
    Technol Cancer Res Treat 4:699-705. 2005
    ..We also find that the use of multiple pulses appears to be more effective for cancer cell ablation than the application of the same energy in one single pulse...
  45. ncbi request reprint Timing of aspirin administration as a determinant of survival of patients with acute myocardial infarction treated with thrombolysis
    Dov Freimark
    The Heart Institute, Sheba Medical Center, Tel Aviv University, Tel Hashomer, Israel
    Am J Cardiol 89:381-5. 2002
    ..39, 95% confidence interval 0.17 to 0.82), and at 1 year (odds ratio 0.41, 95% confidence interval 0.21 to 0.74). Our study proposes a time-dependent benefit from aspirin in patients with AMI treated with thrombolysis...
  46. ncbi request reprint Prolonged 24-hour subzero preservation of heterotopically transplanted rat hearts using antifreeze proteins derived from arctic fish
    Gabriel Amir
    Heart Transplantation Unit, Department of Cardiac Surgery, Sheba Medical Center, Tel Hashomer, Israel
    Ann Thorac Surg 77:1648-55. 2004
    ..We report 24-hour storage of mammalian hearts for transplantation at subzero temperatures using AFPs derived from arctic fish...
  47. ncbi request reprint Trends in management, hospital and long-term outcomes of elderly patients with acute myocardial infarction
    Shmuel Gottlieb
    Cardiology Department, Bikur Cholim Hospital, Jerusalem Hashomer
    Am J Med 120:90-7. 2007
    ..Several studies have reported a decline in mortality after myocardial infarction; however, the magnitude of the decline among the elderly has not been fully investigated...
  48. ncbi request reprint Characteristics, management and outcome of patients with prior coronary bypass surgery presenting with acute myocardial infarction
    Doron Zahger
    Soroka Medical Center, Beer Sheva, Israel
    Cardiology 99:105-10. 2003
    ..Coronary angiography is associated with improved outcome in these patients but is currently used to the same extent as in patients without prior surgery...
  49. ncbi request reprint Editorial: regeneration hope to grow a new heart muscle
    Jonathan Leor
    Heart Fail Rev 8:197-9. 2003
  50. ncbi request reprint Cardiomyocyte transplantation into the failing heart-new therapeutic approach for heart failure?
    Thorsten Reffelmann
    The Heart Institute, Good Samaritan Hospital, University of Southern California, Los Angeles, CA 90017 2395, USA
    Heart Fail Rev 8:201-11. 2003
    ..In this review, we critically evaluate the potential value of cardiomyocyte transplantation as a new approach in the treatment of the syndrome of "heart failure"...
  51. ncbi request reprint Optimization of cardiac cell seeding and distribution in 3D porous alginate scaffolds
    Ayelet Dar
    Department of Biotechnology Engineering and The Institute for Applied Biosciences, Ben Gurion University of the Negev, Beer Sheva 84105 Israel
    Biotechnol Bioeng 80:305-12. 2002
    ..This may enable the development of cardiac cocultures, without domination of cardiofibroblasts with time...
  52. ncbi request reprint Rebuilding broken hearts. Biologists and engineers working together in the fledgling field of tissue engineering are within reach of one of their greatest goals: constructing a living human heart patch
    Smadar Cohen
    Ben Gurion University of the Negev, Isreal
    Sci Am 291:44-51. 2004
    ..Unlike liver or skin, heart tissue cannot regenerate, so the scar left after a heart attack remains a noncontractile dead zone...
  53. doi request reprint Myocardial repair: from salvage to tissue reconstruction
    Emil Ruvinov
    Department of Biotechnology Engineering, Ben Gurion University of the Negev, Beer Sheva 84105, Israel
    Expert Rev Cardiovasc Ther 6:669-86. 2008
    ..Finally, we consider novel approaches to myocardial tissue engineering as a platform for the integration of various modalities in an attempt to rejuvenate infarcted tissue in vivo...
  54. ncbi request reprint Influence of the new definition of acute myocardial infarction on coronary care unit admission, discharge diagnosis, management and outcome in patients with non-ST elevation acute coronary syndromes: a national survey
    Doron Zahger
    Department of Cardiology, Soroka Medical Center, Beer Sheva, Israel
    Int J Cardiol 106:164-9. 2006
    ..Major changes occurred recently in the definition and recommended management of non-ST segment elevation acute coronary syndromes (NSTE ACS). The impact of these changes on the coronary care unit (CCU) is incompletely characterized...
  55. ncbi request reprint Autospecies and post-myocardial infarction sera enhance the viability, proliferation, and maturation of 3D cardiac cell culture
    Ran Schwarzkopf
    Department of Biotechnology Engineering, Ben Gurion University of the Negev, Beer Sheva, Israel
    Tissue Eng 12:3467-75. 2006
    ..The results presented in this study indicate that media supplemented with post-MI adult rat serum and normal adult rat serum compared to FCS have a significant advantage in the regeneration of injured cardiac tissue...
  56. ncbi request reprint Late mortality and determinants in patients with heart failure and preserved systolic left ventricular function: the Israel Nationwide Heart Failure Survey
    Basil S Lewis
    Department of Cardiovascular Medicine, Lady Davis Carmel Medical Center, Haifa, Israel
    Isr Med Assoc J 9:234-8. 2007
    ..Heart failure with preserved systolic left ventricular function is a major cause of cardiac disability...
  57. ncbi request reprint Recommendations for the structure, organization, and operation of intensive cardiac care units
    Yonathan Hasin
    Poria Medical Center, M P Lower Galilee, Tiberias, Israel
    Eur Heart J 26:1676-82. 2005
    ..The desired function is discussed, namely, the patients to be admitted, the length of stay, and the relocation policy. A uniformed electronic chart for ICCUs is advised, anticipating a common European database...
  58. ncbi request reprint Presenting symptoms, admission electrocardiogram, management, and prognosis in acute coronary syndromes: differences by age
    Shlomo Stern
    Heiden Department of Cardiology, Bikur Cholim Hospital, Jerusalem, Israel
    Am J Geriatr Cardiol 13:188-96. 2004
    ..Seven-day, 30-day, and 1-year mortality increased with advancing age. No anginal pain/atypical symptoms on presentation were associated with an increased early and late mortality in all three age subgroups...
  59. ncbi request reprint Endothelial progenitors: a new Tower of Babel?
    Jonathan Leor
    J Am Coll Cardiol 48:1588-90. 2006
  60. pmc Coronary intervention for persistent occlusion after myocardial infarction
    Judith S Hochman
    Cardiovascular Clinical Research Center, Leon Charney Division of Cardiology, New York University School of Medicine, New York 10016, USA
    N Engl J Med 355:2395-407. 2006
    ....
  61. ncbi request reprint Status of glucose metabolism in patients with heart failure secondary to coronary artery disease
    Alexander Tenenbaum
    Cardiac Rehabilitation Institute, Tel Aviv, Israel
    Am J Cardiol 90:529-32. 2002