L Leibovici

Summary

Affiliation: Tel Aviv University
Country: Israel

Publications

  1. doi request reprint Long-term consequences of severe infections
    L Leibovici
    Department of Medicine E, Beilinson Hospital, Rabin Medical Centre, Petah Tiqva, Isreal
    Clin Microbiol Infect 19:510-2. 2013
  2. ncbi request reprint Relative tachycardia in patients with sepsis: an independent risk factor for mortality
    L Leibovici
    Department of Medicine E, Rabin Medical Center, Beilinson Campus, and Sackler Faculty of Medicine, Petah Tiqva 49100, Tel Aviv University, Israel
    QJM 100:629-34. 2007
  3. doi request reprint Non-antibiotic treatment for bacterial infections: how to validate chance findings
    L Leibovici
    Department of Medicine E, Beilinson Campus, Rabin Medical Center, Petah Tiqva, Israel
    Clin Microbiol Infect 15:298-301. 2009
  4. doi request reprint Aminoglycoside-containing antibiotic combinations for the treatment of bacterial endocarditis: an evidence-based approach
    Leonard Leibovici
    Department of Medicine E, Rabin Medical Center, Beilinson Hospital, Petah Tiqva, Israel
    Int J Antimicrob Agents 36:S46-9. 2010
  5. ncbi request reprint Aminoglycoside/beta-lactam combinations in clinical practice
    Leonard Leibovici
    Department of Medicine E, Beilinson Campus, Petah Tiqva 49100, Israel
    J Antimicrob Chemother 60:911-2. 2007
  6. doi request reprint Balancing the benefits and costs of antibiotic drugs: the TREAT model
    L Leibovici
    Department of Medicine E, Beilinson Hospital, Rabin Medical Center, Petah Tiqva, Israel
    Clin Microbiol Infect 16:1736-9. 2010
  7. ncbi request reprint Considering resistance in systematic reviews of antibiotic treatment
    Leonard Leibovici
    Department of Medicine E, Beilinson Campus, Rabin Medical Center, Petah Tiqva 49100, Israel
    J Antimicrob Chemother 52:564-71. 2003
  8. doi request reprint Systematic reviews and meta-analyses in infectious diseases: how are they done and what are their strengths and limitations?
    Leonard Leibovici
    Department of Medicine E, Rabin Medical Center, Petah Tiqva, Israel
    Infect Dis Clin North Am 23:181-94. 2009
  9. doi request reprint Aminoglycoside drugs in clinical practice: an evidence-based approach
    Leonard Leibovici
    Department of Medicine E, Beilinson Campus, Petah Tiqva 49100, Israel
    J Antimicrob Chemother 63:246-51. 2009
  10. doi request reprint Ethical dilemmas in antibiotic treatment
    Leonard Leibovici
    Department of Medicine E, Beilinson Hospital, Rabin Medical Center, Petah Tiqva, Israel
    J Antimicrob Chemother 67:12-6. 2012

Collaborators

Detail Information

Publications98

  1. doi request reprint Long-term consequences of severe infections
    L Leibovici
    Department of Medicine E, Beilinson Hospital, Rabin Medical Centre, Petah Tiqva, Isreal
    Clin Microbiol Infect 19:510-2. 2013
    ..The true answer for whether one treatment is better than another in severe infections or sepsis lies in the people trajectory in the year following the infection, and not only on 4-6 weeks outcome...
  2. ncbi request reprint Relative tachycardia in patients with sepsis: an independent risk factor for mortality
    L Leibovici
    Department of Medicine E, Rabin Medical Center, Beilinson Campus, and Sackler Faculty of Medicine, Petah Tiqva 49100, Tel Aviv University, Israel
    QJM 100:629-34. 2007
    ..Excess activation of the sympathetic nervous system may be a risk factor for mortality in patients with the systemic inflammatory response syndrome (SIRS) or sepsis...
  3. doi request reprint Non-antibiotic treatment for bacterial infections: how to validate chance findings
    L Leibovici
    Department of Medicine E, Beilinson Campus, Rabin Medical Center, Petah Tiqva, Israel
    Clin Microbiol Infect 15:298-301. 2009
    ..For all the questions examined here, we have not yet passed the threshold of evidence needed to offer patients participation in randomized controlled trials...
  4. doi request reprint Aminoglycoside-containing antibiotic combinations for the treatment of bacterial endocarditis: an evidence-based approach
    Leonard Leibovici
    Department of Medicine E, Rabin Medical Center, Beilinson Hospital, Petah Tiqva, Israel
    Int J Antimicrob Agents 36:S46-9. 2010
    ..Large randomised clinical trials are needed to answer this question; they need to include about 600 patients per patient/pathogen group and thus a multicentre, probably international, effort is needed...
  5. ncbi request reprint Aminoglycoside/beta-lactam combinations in clinical practice
    Leonard Leibovici
    Department of Medicine E, Beilinson Campus, Petah Tiqva 49100, Israel
    J Antimicrob Chemother 60:911-2. 2007
    ....
  6. doi request reprint Balancing the benefits and costs of antibiotic drugs: the TREAT model
    L Leibovici
    Department of Medicine E, Beilinson Hospital, Rabin Medical Center, Petah Tiqva, Israel
    Clin Microbiol Infect 16:1736-9. 2010
    ..the present, individual patient...
  7. ncbi request reprint Considering resistance in systematic reviews of antibiotic treatment
    Leonard Leibovici
    Department of Medicine E, Beilinson Campus, Rabin Medical Center, Petah Tiqva 49100, Israel
    J Antimicrob Chemother 52:564-71. 2003
    ..Systematic reviews on antibiotic drugs that ignore the topic of resistance present readers with a skewed view, emphasizing short-term efficacy or effectiveness while ignoring long-term consequences...
  8. doi request reprint Systematic reviews and meta-analyses in infectious diseases: how are they done and what are their strengths and limitations?
    Leonard Leibovici
    Department of Medicine E, Rabin Medical Center, Petah Tiqva, Israel
    Infect Dis Clin North Am 23:181-94. 2009
    ..Practitioners should familiarize themselves with the methodology of systematic reviews and meta-analyses, their interpretation, and their limitations...
  9. doi request reprint Aminoglycoside drugs in clinical practice: an evidence-based approach
    Leonard Leibovici
    Department of Medicine E, Beilinson Campus, Petah Tiqva 49100, Israel
    J Antimicrob Chemother 63:246-51. 2009
    ..They probably induce less resistance. Pragmatic large trials are needed to answer open clinical questions on the use of aminoglycosides...
  10. doi request reprint Ethical dilemmas in antibiotic treatment
    Leonard Leibovici
    Department of Medicine E, Beilinson Hospital, Rabin Medical Center, Petah Tiqva, Israel
    J Antimicrob Chemother 67:12-6. 2012
    ..None of these solve the problem of patients' autonomy. We see no other way but to argue that the right of future patients to come to less harm outweighs the right of the present patient to share in decisions on antibiotic treatment...
  11. pmc Effects of remote, retroactive intercessory prayer on outcomes in patients with bloodstream infection: randomised controlled trial
    L Leibovici
    Department of Medicine, Beilinson Campus, Rabin Medical Center, Petah Tiqva 49100, Israel
    BMJ 323:1450-1. 2001
    ..To determine whether remote, retroactive intercessory prayer, said for a group of patients with a bloodstream infection, has an effect on outcomes...
  12. pmc Monotherapy versus beta-lactam-aminoglycoside combination treatment for gram-negative bacteremia: a prospective, observational study
    L Leibovici
    Department of Medicine, Rabin Medical Center, Beilinson Campus, Petah Tiqva, Israel
    Antimicrob Agents Chemother 41:1127-33. 1997
    ..2; 95% CI, 0.05 to 0.7). In summary, combination treatment showed no advantage over treatment with an appropriate beta-lactam drug in nonneutropenic patients with gram-negative bacteremia...
  13. ncbi request reprint Antibiotic prophylaxis in neutropenic patients: new evidence, practical decisions
    Leonard Leibovici
    Department of Medicine E, Beilinson Campus, Rabin Medical Center, Petah Tiqva, Israel
    Cancer 107:1743-51. 2006
    ..Excessive local levels of resistance to fluoroquinolones or high local incidence of infections caused by Clostridium difficile and related to fluoroquinolones should prompt a reconsideration of this policy...
  14. ncbi request reprint Departmental consumption of antibiotic drugs and subsequent resistance: a quantitative link
    L Leibovici
    Department of Medicine, Rabin Medical Center, Beilinson Campus, Petah Tiqva, Israel
    J Antimicrob Chemother 48:535-40. 2001
    ..To look for a quantitative model linking departmental consumption of antibiotic drugs to the subsequent isolation of resistant hospital-acquired coliform pathogens...
  15. ncbi request reprint [The clinician-scientist: proposal for a new paradigm]
    Leonard Leibovici
    Department of Medicine E, Beilinson Tiqva
    Harefuah 149:661-4, 683. 2010
    ..The clinician-scientist should perform medical research. Investing in this paradigm wilt encourage young doctors to conduct research directly oriented to benefit their patients...
  16. ncbi request reprint Improving empirical antibiotic treatment: prospective, nonintervention testing of a decision support system
    L Leibovici
    Department of Medicine, Rabin Medical Centre, Beilinson Campus, Petah Tiqva, Israel
    J Intern Med 242:395-400. 1997
    ..Develop a problem-orientated and data-based decision support system (DSS) to improve empirical antibiotic treatment, and compare the performance of the system to that of the physician...
  17. ncbi request reprint The benefit of appropriate empirical antibiotic treatment in patients with bloodstream infection
    L Leibovici
    Department of Medicine E, Beilinson Hospital, Petah Tiqva, Israel
    J Intern Med 244:379-86. 1998
    ..To test whether empirical antibiotic treatment that matches the in vitro susceptibility of the pathogen (appropriate treatment) improves survival in patients with bloodstream infections; and to measure the improvement...
  18. ncbi request reprint The need for macrolides in hospitalised community-acquired pneumonia: propensity analysis
    M Paul
    Department of Medicine E, Rabin Medical Center, Beilinson Hospital, 49100 Petah Tiqva, Israel
    Eur Respir J 30:525-31. 2007
    ..69 (95% confidence interval 0.32-1.48). The benefit of combination therapy versus monotherapy cannot be reliably assessed in observational studies, since the propensity to prescribe these regimens differs markedly...
  19. ncbi request reprint The significance of Acinetobacter baumannii bacteraemia compared with Klebsiella pneumoniae bacteraemia: risk factors and outcomes
    E Robenshtok
    Department of Medicine E, Rabin Medical Centre, Beilinson Campus, Petach Tikva, Israel
    J Hosp Infect 64:282-7. 2006
    ..e. those who were not ventilated and those who did not present with septic shock. These results support the view that nosocomial bacteraemia due to A. baumannii is associated with increased mortality...
  20. ncbi request reprint Seven-year study of bacteraemic pneumonia in a single institution
    J Bishara
    Department of Internal Medicine C, Rabin Medical Centre, Sackler School of Medicine, Tel Aviv University, Petach Tikvah, Israel
    Eur J Clin Microbiol Infect Dis 19:926-31. 2000
    ....
  21. ncbi request reprint Excess mortality in women with hospital-acquired bloodstream infection
    L Leibovici
    Department of Medicine, Rabin Medical Center, Beilinson Campus, Petah-Tiqva, Israel
    Am J Med 111:120-5. 2001
    ..The excess mortality was concentrated in women with severe underlying disorders, suggesting that sepsis might have accentuated differences in the outcome of underlying disorders in women...
  22. doi request reprint Are all beta-lactams similarly effective in the treatment of methicillin-sensitive Staphylococcus aureus bacteraemia?
    M Paul
    Unit of Infectious Diseases, Rabin Medical Center, Beilinson Hospital, Petah Tikva, Israel
    Clin Microbiol Infect 17:1581-6. 2011
    ....
  23. doi request reprint Consequences of treated versus untreated asymptomatic bacteriuria in the first year following kidney transplantation: retrospective observational study
    H Green
    Department of Nephrology and Hypertension, Rabin Medical Center, Beilinson Campus, Petah Tikva 49100, Israel
    Eur J Clin Microbiol Infect Dis 32:127-31. 2013
    ..We observed no benefit for the antibiotic treatment of AB in the short- and long-term follow-up. A prospective observational study is needed...
  24. ncbi request reprint Persistent bacteremia in the absence of defined intravascular foci: clinical significance and risk factors
    M Y Chowers
    Sackler Faculty of Medicine, Tel Aviv University, Ramat Aviv, Tel Aviv, Israel
    Eur J Clin Microbiol Infect Dis 22:592-6. 2003
    ..Because of the high mortality associated with persistent bacteremia, a thorough search for the source of infection is essential to ensure timely and appropriate therapy...
  25. ncbi request reprint Antibiotic prophylaxis of bacterial infections in cirrhotic inpatients: a meta-analysis of randomized controlled trials
    K Soares-Weiser
    Dept of Medicine E, Beilinson Campus, Rabin Medical Center, Petah Tikva, Israel
    Scand J Gastroenterol 38:193-200. 2003
    ..We performed a systematic review to evaluate the efficacy of antibiotic prophylaxis in inpatients with cirrhosis, regardless of the underlying risk factors that led to hospital admission...
  26. ncbi request reprint Correlation between candiduria and departmental antibiotic use
    M Weinberger
    The Sackler School of Medicine, Tel Aviv University, Ramat Aviv, Israel
    J Hosp Infect 53:183-6. 2003
    ..These results add an important new dimension to the strategy of restricting broad-spectrum antibiotics...
  27. ncbi request reprint Patterns of multiple resistance to antibiotics in gram-negative bacteria demonstrated by factor analysis
    L Leibovici
    Department of Medicine B, Beilinson Medical Centre, Petah Tiqva, Israel
    Eur J Clin Microbiol Infect Dis 11:782-8. 1992
    ..Factor analysis can be used to describe phenotypic associations between resistance to antibiotics, and the factor score used to compare groups of isolates and to demonstrate temporal and other trends...
  28. doi request reprint Macrolides vs. quinolones for community-acquired pneumonia: meta-analysis of randomized controlled trials
    K Skalsky
    Medicine E, Rabin Medical Center, Beilinson Hospital, Petah Tikva, Israel
    Clin Microbiol Infect 19:370-8. 2013
    ..The clinical significance of this advantage is unclear...
  29. ncbi request reprint Characteristics of candidaemia with Candida-albicans compared with non-albicans Candida species and predictors of mortality
    M Weinberger
    Internal Medicine C and Infectious Diseases, Rabin Medical Centre, Beilinson Campus, Petach Tikva, Israel
    J Hosp Infect 61:146-54. 2005
    ..When shock was excluded from analysis, antifungal therapy was shown to be protective. Unlike previous concerns, infection with Candida species other than C. albicans has not been shown to result in an increased fatality rate...
  30. pmc Beta lactam monotherapy versus beta lactam-aminoglycoside combination therapy for fever with neutropenia: systematic review and meta-analysis
    Mical Paul
    Rabin Medical Centre, Beilinson Campus, Infectious Diseases Unit and Department of Medicine E, Petah Tiqva 49100, Israel
    BMJ 326:1111. 2003
    ..To compare the effectiveness of beta lactam monotherapy versus beta lactam-aminoglycoside combination therapy in the treatment of patients with fever and neutropenia...
  31. ncbi request reprint Long-term outcome of infective endocarditis: the impact of early surgical intervention
    J Bishara
    Department of Internal Medicine C, Rabin Medical Center, Beilinson Campus, Petach Tikvah, Israel
    Clin Infect Dis 33:1636-43. 2001
    ..1). Early surgical intervention compared with medical therapy alone is associated with increased short- and long-term survival rates in patients with IE, primarily when IE is caused by S. aureus...
  32. ncbi request reprint Antibiotic use in patients with erysipelas: a retrospective study
    J Bishara
    Department of Internal Medicine, Rabin Medical Center Beilinson Campus, Petah Tiqva, Israel
    Isr Med Assoc J 3:722-4. 2001
    ..Erysipelas is a skin infection generally caused by group A streptococci. Although penicillin is the drug of choice, some physicians tend to treat erysipelas with antibiotics other than penicillin...
  33. ncbi request reprint Prophylactic use of antibiotics for prevention of meningococcal infections: systematic review and meta-analysis of randomised trials
    A Fraser
    Department of Medicine E, Rabin Medical Center, Beilinson Campus, Petah Tiqva, 49100, Israel
    Eur J Clin Microbiol Infect Dis 24:172-81. 2005
    ..Given that the use of rifampin in an outbreak setting might lead to the circulation of isolates resistant to rifampin, the use of ciprofloxacin and ceftriaxone should be considered...
  34. pmc Evidence based case report. Antibiotic treatment for spontaneous bacterial peritonitis
    K Soares-Weiser
    Department of Medicine E, Rabin Medical Center, Petah Tikva, Israel
    BMJ 324:100-2. 2002
  35. ncbi request reprint The anti-cancer effects of quinolone antibiotics?
    M Paul
    Department of Medicine E and Infectious Diseases Unit, Rabin Medical Center, Beilinson Hospital, Petah Tikva, 49100, Israel
    Eur J Clin Microbiol Infect Dis 26:825-31. 2007
    ..93, 15 trials, 3,320 patients). This finding might represent biased attribution of deaths to infection or might be compatible with an anti-cancer effect of quinolone antibiotics. We present further analyses addressing these possibilities...
  36. doi request reprint Importance of appropriate empirical antibiotic therapy for methicillin-resistant Staphylococcus aureus bacteraemia
    Mical Paul
    Unit of Infectious Diseases, Rabin Medical Center, Beilinson Hospital, Petah Tiqva, Israel
    J Antimicrob Chemother 65:2658-65. 2010
    ....
  37. ncbi request reprint Antibiotic prophylaxis in neutropenic patients
    Anat Gafter-Gvili
    Department of Medicine E, Rabin Medical Center Beilinson Campus, Petah Tikva, Israel
    Isr Med Assoc J 9:460-2. 2007
  38. pmc Systematic review and meta-analysis of the efficacy of appropriate empiric antibiotic therapy for sepsis
    Mical Paul
    Unit of Infectious Diseases, Rabin Medical Center, Beilinson Hospital, Petach Tikva, Israel
    Antimicrob Agents Chemother 54:4851-63. 2010
    ..However, the methods used in the observational studies significantly affect the effect size reported. Methods of observational studies assessing the effects of antibiotic treatment should be improved and standardized...
  39. doi request reprint Reporting of adverse events in randomized controlled trials of highly active antiretroviral therapy: systematic review
    Michal Y Chowers
    Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    J Antimicrob Chemother 64:239-50. 2009
    ....
  40. doi request reprint Effectiveness and safety of colistin: prospective comparative cohort study
    Mical Paul
    Unit of Infectious Diseases, Rabin Medical Center, Beilinson Hospital, Petah Tikva, Israel
    J Antimicrob Chemother 65:1019-27. 2010
    ..Colistin has re-entered clinical use by necessity. We aimed to assess its effectiveness and safety compared with newer antibiotics...
  41. ncbi request reprint Effect of quinolone prophylaxis in afebrile neutropenic patients on microbial resistance: systematic review and meta-analysis
    Anat Gafter-Gvili
    Department of Medicine E, Beilinson Campus, Rabin Medical Center, Petah Tiqva, Israel
    J Antimicrob Chemother 59:5-22. 2007
    ..To assess the effect of quinolone prophylaxis following chemotherapy for malignancies on the emergence of resistant bacteria in neutropenic patients...
  42. ncbi request reprint Oral versus intravenous antibiotic treatment for febrile neutropenia in cancer patients: a systematic review and meta-analysis of randomized trials
    Liat Vidal
    Department of Medicine E, Beilinson Campus, Rabin Medical Center, Petah Tiqva 49100
    J Antimicrob Chemother 54:29-37. 2004
    ..Oral therapy could be an alternative approach for selected patients...
  43. pmc Assessing ethics of trials in systematic reviews
    Michael A Weingarten
    Department of Family Medicine, Tel Aviv University, Tel Aviv, Israel
    BMJ 328:1013-4. 2004
  44. ncbi request reprint Screening for cervical cancer--an evidence-based approach
    A Fraser
    Department of Medicine E, Rabin Medical Center, Beilinson Campus, Petah Tikva, Israel
    Eur J Gynaecol Oncol 26:372-5. 2005
    ..In Israel only opportunistic screening exists and still the incidence of invasive cervical cancer is among the lowest in the world...
  45. doi request reprint Lamivudine prevents reactivation of hepatitis B and reduces mortality in immunosuppressed patients: systematic review and meta-analysis
    L H Katz
    Department of Medicine D and Liver Institute, Beilinson Campus, Rabin Medical Center, Petah Tiqva, Israel
    J Viral Hepat 15:89-102. 2008
    ..Lamivudine should be administered prophylactically to HBsAg-positive patients who are about to receive immunosuppressive therapy...
  46. ncbi request reprint Empirical antibiotics against Gram-positive infections for febrile neutropenia: systematic review and meta-analysis of randomized controlled trials
    Mical Paul
    Department of Medicine E, Rabin Medical Center, Beilinson Campus, 49100 Petah Tiqva
    J Antimicrob Chemother 55:436-44. 2005
    ..To assess the value of empirical anti-Gram-positive antibiotics for the treatment of febrile neutropenia...
  47. ncbi request reprint Three-day vs longer duration of antibiotic treatment for cystitis in women: systematic review and meta-analysis
    Eugene A Katchman
    Department of Medicine E, Rabin Medical Center, Beilinson Campus, Petah Tiqva, Israel
    Am J Med 118:1196-207. 2005
    ..We performed a meta-analysis to ascertain the efficacy and safety of the currently practiced 3-day antibiotic therapy for cystitis versus prolonged therapy (5 days or longer) to relieve symptoms and to achieve bacteriological cure...
  48. ncbi request reprint Meta-analysis: antibiotic prophylaxis reduces mortality in neutropenic patients
    Anat Gafter-Gvili
    Rabin Medical Center, Petah Tiqva, Israel
    Ann Intern Med 142:979-95. 2005
    ..Trials have shown the efficacy of antibiotic prophylaxis in decreasing the incidence of bacterial infections but not in reducing mortality rates...
  49. ncbi request reprint The epidemiology of bacteremia with febrile neutropenia: experience from a single center, 1988-2004
    Mical Paul
    Department of Medicine E, Rabin Medical Center Beilinson Campus, Petah Tikva, Israel
    Isr Med Assoc J 9:424-9. 2007
    ..The epidemiology of bacteremic febrile neutropenia differs between locations and constitutes the basis for selection of empiric antibiotic therapy for febrile neutropenia...
  50. ncbi request reprint Seven-year study of bacteremia in hospitalized patients on chronic hemodialysis in a single tertiary hospital
    Haim Shmuely
    Department of Internal Medicine C Unit of Infectious Diseases, Rabin Medical Center, Beilinson Campus, Petach Tikva, Israel
    Ren Fail 25:579-88. 2003
    ..Predictors of mortality were: advanced age, decreased functional capacity, and malignancies. Most common organisms recovered were Staphylococcus aureus (30%), coagulase negative Staphylococcus (15%), and polymicrobial agents (15%)...
  51. pmc Beta lactam monotherapy versus beta lactam-aminoglycoside combination therapy for sepsis in immunocompetent patients: systematic review and meta-analysis of randomised trials
    Mical Paul
    Department of Medicine E and Infectious Diseases Unit, Rabin Medical Centre, Beilinson Campus, Petah Tikva 49100, Israel
    BMJ 328:668. 2004
    ..To compare beta lactam monotherapy with beta lactam-aminoglycoside combination therapy for severe infections...
  52. ncbi request reprint Prediction of specific pathogens in patients with sepsis: evaluation of TREAT, a computerized decision support system
    Mical Paul
    Department of Medicine E, Rabin Medical Center, Beilinson Campus, Petah Tiqva, Israel
    J Antimicrob Chemother 59:1204-7. 2007
    ..Prediction of bacterial infections and their pathogens allows for early, directed investigation and treatment. We assessed the ability of TREAT, a computerized decision support system, to predict specific pathogens...
  53. ncbi request reprint Efficacy and safety of cefepime: a systematic review and meta-analysis
    Dafna Yahav
    Department of Medicine E, Rabin Medical Center, Petah Tiqva, Israel
    Lancet Infect Dis 7:338-48. 2007
    ..This Review provides evidence and offers possible explanations for increased mortality among patients treated with cefepime in randomised trials...
  54. ncbi request reprint Efficacy and safety of aminoglycoside monotherapy: systematic review and meta-analysis of randomized controlled trials
    Liat Vidal
    Department of Internal Medicine E, Rabin Medical Center, Beilinson Campus, Petah Tikva 49100, Israel
    J Antimicrob Chemother 60:247-57. 2007
    ..This study sought to compare the efficacy and adverse effects of any aminoglycoside as a single antibiotic with other antibiotics for the treatment of patients with infection...
  55. doi request reprint Systematic reviews and meta-analyses in infectious diseases: topics that merit special attention
    L Leibovici
    Department of Medicine E, Rabin Medical Centre, Beilinson Hospital, Petah Tiqva, Israel Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    Clin Microbiol Infect 20:101-4. 2014
    ..Resistance as an outcome is a topic that should be addressed in all SRs of antibiotic treatment. Ethical aspects and especially patients' safety should be addressed in SRs. ..
  56. doi request reprint Benchmarking inappropriate empirical antibiotic treatment
    G Kariv
    Department of Medicine E, Rabin Medical Centre, Beilinson Hospital, Petah Tikva, Israel
    Clin Microbiol Infect 19:629-33. 2013
    ..Based on the control limits found, at least 500 patients should be evaluated before establishing a local rate. Lower and higher than expected rates might indicate overly aggressive treatment or poor performance, respectively...
  57. doi request reprint Cost-benefit of infection control interventions targeting methicillin-resistant Staphylococcus aureus in hospitals: systematic review
    L Farbman
    Medicine E, Rabin Medical Centre, Beilinson Hospital, Petah Tikva, Israel Leon Recanati Faculty of Management and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    Clin Microbiol Infect 19:E582-93. 2013
    ..This was true also for high MRSA endemicity settings. Unresolved economic issues include rapid screening using molecular techniques and universal versus targeted screening...
  58. ncbi request reprint Treatment of latent tuberculosis in persons at risk for multidrug-resistant tuberculosis: systematic review
    A Fraser
    Department of Medicine E, Beilinson Campus, Rabin Medical Center, Petah Tiqva 49100, Israel
    Int J Tuberc Lung Dis 10:19-23. 2006
    ..The emergence and spread of multidrug-resistant tuberculosis (MDR-TB), caused by Mycobacterium tuberculosis resistant to at least isoniazid (INH) and rifampicin, is a threat to global TB control...
  59. ncbi request reprint Anti-pseudomonal beta-lactams for the initial, empirical, treatment of febrile neutropenia: comparison of beta-lactams
    Mical Paul
    Infectious Diseases Unit, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel, 49100
    Cochrane Database Syst Rev 11:CD005197. 2010
    ..Several beta-lactams are recommended as single agents for the treatment of febrile neutropenia...
  60. doi request reprint Combination antimicrobial treatment versus monotherapy: the contribution of meta-analyses
    Mical Paul
    Unit of Infectious Diseases, Rabin Medical Center, Beilinson Campus, Petah Tikva, Israel
    Infect Dis Clin North Am 23:277-93. 2009
    ....
  61. pmc Comparative efficacy and safety of vancomycin versus teicoplanin: systematic review and meta-analysis
    Shuli Svetitsky
    Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    Antimicrob Agents Chemother 53:4069-79. 2009
    ..44; 95% CI, 0.32 to 0.61), and red man syndrome were significantly less frequent with teicoplanin. Teicoplanin is not inferior to vancomycin with regard to efficacy and is associated with a lower adverse event rate than vancomycin...
  62. doi request reprint Infection-control interventions for cancer patients after chemotherapy: a systematic review and meta-analysis
    Agata Schlesinger
    Department of Medicine E, Rabin Medical Center, Beilinson Campus, Petah Tikva, Israel
    Lancet Infect Dis 9:97-107. 2009
    ..72 [95% CI 0.55-0.95]. We conclude that prophylactic antibiotics are the most effective treatment within the protective environment. Randomised trials on outpatient management of haematological cancer patients are needed...
  63. pmc Treatment of human brucellosis: systematic review and meta-analysis of randomised controlled trials
    Keren Skalsky
    Internal Medicine E, Rabin Medical Center, Beilinson Hospital, Petah Tikva 49100, Israel
    BMJ 336:701-4. 2008
    ..To determine and quantify differences in efficacy between treatment regimens for brucellosis...
  64. ncbi request reprint Improving empirical antibiotic treatment using TREAT, a computerized decision support system: cluster randomized trial
    Mical Paul
    Department of Medicine E, Rabin Medical Center, Beilinson Campus, 49100 Petah Tiqva, Israel
    J Antimicrob Chemother 58:1238-45. 2006
    ..Appropriate antibiotic treatment decreases mortality, while superfluous treatment is associated with antibiotic resistance. We built a computerized decision support system for antibiotic treatment (TREAT) targeting these outcomes...
  65. ncbi request reprint Empirical antibiotic monotherapy for febrile neutropenia: systematic review and meta-analysis of randomized controlled trials
    Mical Paul
    Department of Medicine E, Rabin Medical Center, Beilinson Campus, 49100 Petah Tiqva, Israel
    J Antimicrob Chemother 57:176-89. 2006
    ..Early, empirical broad-spectrum antibiotic treatment is the established practice for febrile neutropenia. Several beta-lactams are accepted for monotherapy. We asked whether patients' outcomes are influenced by the chosen beta-lactam...
  66. doi request reprint Colistin: new lessons on an old antibiotic
    D Yahav
    Internal Medicine E, Rabin Medical Centre, Beilinson Hospital, Petah Tikva, Israel
    Clin Microbiol Infect 18:18-29. 2012
    ..Synergy with carbapenem, rifampin and other antibiotics has been reported in vitro. Randomized controlled trials are ongoing or in planning to assess this and other aspects of colistin use in clinical practice...
  67. doi request reprint Nucleoside reverse transcriptase inhibitors in combination therapy for HIV patients: systematic review and meta-analysis
    M Chowers
    Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    Eur J Clin Microbiol Infect Dis 29:779-86. 2010
    ..This combination, soon to be generic, should be compared to the current standard of care in a large randomized trial. An effective, safe, and inexpensive alternative to current options is needed...
  68. ncbi request reprint Empirical atypical coverage for inpatients with community-acquired pneumonia: systematic review of randomized controlled trials
    Daphna Shefet
    Department of Medicine E, Beilinson Campus, Rabin Medical Center, Petah Tiqva, Israel
    Arch Intern Med 165:1992-2000. 2005
    ..Our goal was to assess the efficacy of empirical coverage of atypical pathogens in terms of mortality and clinical and bacteriological success...
  69. doi request reprint Co-trimoxazole versus vancomycin for the treatment of methicillin-resistant Staphylococcus aureus bacteraemia: a retrospective cohort study
    Elad Goldberg
    Infectious Diseases Unit, Rabin Medical Center, Beilinson Hospital, Petah Tiqva, Israel
    J Antimicrob Chemother 65:1779-83. 2010
    ..To evaluate the efficacy and safety of co-trimoxazole versus that of vancomycin in adults with methicillin-resistant Staphylococcus aureus (MRSA) bacteraemia...
  70. doi request reprint Empirical antifungal therapy for patients with neutropenia and persistent fever: Systematic review and meta-analysis
    Elad Goldberg
    Department of Medicine E, Rabin Medical Center, Beilinson Campus, 49100 Petah Tiqva, Israel
    Eur J Cancer 44:2192-203. 2008
    ..To assess the evidence for the current standard of practice of using empirical antifungal treatment in febrile neutropenic cancer patients...
  71. pmc Prophylactic antibiotics for burns patients: systematic review and meta-analysis
    Tomer Avni
    Department of Medicine E, Rabin Medical Center, Beilinson Hospital, Sackler Faculty of Medicine, Tel Aviv University, Israel
    BMJ 340:c241. 2010
    ..To assess the evidence for prophylactic treatment with systemic antibiotics in burns patients...
  72. doi request reprint Rituximab maintenance for the treatment of patients with follicular lymphoma: systematic review and meta-analysis of randomized trials
    Liat Vidal
    Institute of Hematology, Beilinson Hospital, Rabin Medical Center, Petah Tikva, Israel
    J Natl Cancer Inst 101:248-55. 2009
    ..We aimed to evaluate the effect of maintenance treatment with rituximab on the overall survival of patients with follicular lymphoma...
  73. ncbi request reprint Surveillance of infectious complications in hemato-oncological patients
    Ron Ram
    Institute of Hematology, Rabin Medical Center, Beilinson Campus, Petah Tikva, Israel
    Isr Med Assoc J 11:133-7. 2009
    ..Monitoring the rate of infections in individual centers that treat patients with hematological malignancies is of major importance. However, there are no uniform guidelines for infection surveillance...
  74. ncbi request reprint The TREAT project: decision support and prediction using causal probabilistic networks
    Leonard Leibovici
    Department of Medicine E, Rabin Medical Center, Beilinson Campus, Petah Tiqva, Israel
    Int J Antimicrob Agents 30:S93-102. 2007
    ..In the present review we discuss the advantages of using causal probabilistic models for prediction and decision support, and the various decisions that were taken in the TREAT project...
  75. pmc Co-trimoxazole-sensitive, methicillin-resistant Staphylococcus aureus, Israel, 1988-1997
    Jihad Bishara
    Department of Internal Medicine C, Rabin Medical Center, Beilinson Campus, Petach Tikvah, Israel
    Emerg Infect Dis 9:1168-9. 2003
    ..0001). If also observed in other institutions, these findings should encourage the performance of a clinical trial of sufficient size to compare co-trimoxazole to vancomycin in treating MRSA infections...
  76. doi request reprint Duration of antibiotic prophylaxis for cardiac surgery: prospective observational study
    Mical Paul
    Unit of Infectious Diseases, Rabin Medical Center, Beilinson Hospital and Sackler Faculty of Medicine, Tel Aviv University, Petah Tikva, Israel
    J Infect 58:291-8. 2009
    ..To assess the effect of prolonging antibiotic prophylaxis in cardiac surgery...
  77. ncbi request reprint Thyroxine-triiodothyronine combination therapy versus thyroxine monotherapy for clinical hypothyroidism: meta-analysis of randomized controlled trials
    Simona Grozinsky-Glasberg
    Department of Medicine E, Beilinson Campus, Petah Tiqva 49100, Israel
    J Clin Endocrinol Metab 91:2592-9. 2006
    ..In some patients symptoms of hypothyroidism persist despite therapy with T(4)...
  78. ncbi request reprint Combination antibiotic therapy for Pseudomonas aeruginosa bacteraemia
    Mical Paul
    Department of Internal Medicine E, Rabin Medical Centre, Beilinson Campus, Petach Tikva, Israel
    Lancet Infect Dis 5:192-3; discussion 193-4. 2005
  79. ncbi request reprint Prediction of bacteremia using TREAT, a computerized decision-support system
    Mical Paul
    Department of Medicine E, Rabin Medical Center, Beilinson Campus, Petah Tikva, Israel
    Clin Infect Dis 42:1274-82. 2006
    ..Prediction of bloodstream infection at the time of sepsis onset allows one to make appropriate and economical management decisions...
  80. doi request reprint Antimicrobial lock solutions for the prevention of infections associated with intravascular catheters in patients undergoing hemodialysis: systematic review and meta-analysis of randomized, controlled trials
    Dafna Yahav
    Department of Medicine E, Rabin Medical Center, Beilinson Campus, 49100 Petah Tiqva, Israel
    Clin Infect Dis 47:83-93. 2008
    ..Prevention of catheter-related bloodstream infections in patients undergoing hemodialysis by use of antimicrobial catheter lock solutions has been examined in several trials, but no consensus is available for clinical practice...
  81. ncbi request reprint Prophylaxis of Pneumocystis pneumonia in immunocompromised non-HIV-infected patients: systematic review and meta-analysis of randomized controlled trials
    Hefziba Green
    Unit of Infectious Diseases, Rabin Medical Centre, Beilison Hospital, Petah Tikva 49100, Israel
    Mayo Clin Proc 82:1052-9. 2007
    ..To assess the efficacy of prophylaxis for Pneumocystis pneumonia (PCP), caused by Pneumocystis jirovecii (formerly Pneumocystis carinii), for immunocompromised non-HIV-infected patients by conducting a systematic review and meta-analysis...
  82. ncbi request reprint Sternal wound infection after coronary artery bypass graft surgery: validation of existing risk scores
    Mical Paul
    Department of Internal Medicine E, Rabin Medical Center, Beilinson Hospital and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    J Thorac Cardiovasc Surg 133:397-403. 2007
    ..Prediction of surgical site infection and mortality after cardiac surgery might allow for interventions to reduce adverse outcomes. We sought to evaluate existing risk scores...
  83. ncbi request reprint Benefit of appropriate empirical antibiotic treatment: thirty-day mortality and duration of hospital stay
    Abigail Fraser
    Department of Medicine E, Rabin Medical Center, Beilinson Campus, Petah Tiqva, Israel
    Am J Med 119:970-6. 2006
    ..We evaluated the effect of inappropriate antibiotic treatment on mortality and duration of hospital stay in medical inpatients with bacterial infections...
  84. ncbi request reprint Antifungal prophylaxis in cancer patients after chemotherapy or hematopoietic stem-cell transplantation: systematic review and meta-analysis
    Eyal Robenshtok
    Department of Medicine E, Rabin Medical Center, Petah Tiqva, Israel
    J Clin Oncol 25:5471-89. 2007
    ..Many studies have evaluated the role of antifungal prophylaxis in cancer patients, with inconsistent conclusions...
  85. doi request reprint Pharmacological interventions for fertility preservation during chemotherapy: a systematic review and meta-analysis
    Irit Ben-Aharon
    Institute of Oncology, Davidoff Center, Rabin Medical Center, Beilinson Campus, Petah Tiqwa, Israel
    Breast Cancer Res Treat 122:803-11. 2010
    ..Nevertheless, randomized prospective trials are less conclusive for their real value in conserving ovarian reserve and pregnancy. Large-scale prospective randomized trials are warranted to evaluate the role of GnRHa in preventing CIOF...
  86. doi request reprint Treatment of invasive candidal infections: systematic review and meta-analysis
    Anat Gafter-Gvili
    Department of Hematology, Davidoff Cancer Center, Rabin Medical Center, Beilinson Campus, 49100 Petah Tiqva, Israel
    Mayo Clin Proc 83:1011-21. 2008
    ..To compare available antifungal treatments for invasive candidiasis, a leading cause of nosocomial bloodstream infections...
  87. doi request reprint Antiviral prophylaxis in haematological patients: systematic review and meta-analysis
    Dafna Yahav
    Department of Medicine E, Rabin Medical Center, Beilinson Hospital, Sackler Faculty of Medicine, Tel Aviv University, Israel
    Eur J Cancer 45:3131-48. 2009
    ..Antiviral prophylaxis is commonly prescribed to haematological cancer patients. We conducted a systematic review and meta-analysis to quantify its overall benefit in specific clinical scenarios...
  88. ncbi request reprint Systematic reviews and meta-analyses in the Journal of Antimicrobial Chemotherapy
    Leonard Leibovici
    Department of Medicine E, Rabin Medical Center, Beilinson Campus, 49100 Petah Tiqva, Israel
    J Antimicrob Chemother 56:803-4. 2005
    ..In this article we outline the advantages and limitations inherent in these approaches, and the features that we look for when this type of article is submitted to JAC...
  89. ncbi request reprint Systematic reviews and meta-analysis of febrile neutropenia
    Mical Paul
    Mayo Clin Proc 80:1122-5. 2005
  90. ncbi request reprint Atypical coverage for community-acquired pneumonia
    Eyal Robenshtok
    Am J Respir Crit Care Med 176:1289; author reply 1289-90. 2007
  91. pmc Antibiotic treatment for cystitis
    Leonard Leibovici
    Br J Gen Pract 52:708-10. 2002
  92. ncbi request reprint A stochastic model of susceptibility to antibiotic therapy--The effects of cross-resistance and treatment history
    Alina Zalounina
    Center for Model Based Medical Decision Support, Niels Jernes Vej 14, Aalborg University, 9220 Aalborg East, Denmark
    Artif Intell Med 40:57-63. 2007
    ....
  93. ncbi request reprint Propensity-matched analysis of appropriate empirical antibiotic treatment
    Mical Paul
    Clin Infect Dis 44:1251-2. 2007
  94. pmc Community acquired pneumonia: Antibiotic coverage is atypical: evidence from randomised trials
    Leonard Leibovici
    BMJ 335:1109. 2007
  95. ncbi request reprint Comment on guidelines for the prophylaxis and treatment of methicillin-resistant Staphylococcus aureus (MRSA) infections in the UK
    Leonard Leibovici
    J Antimicrob Chemother 58:220. 2006
  96. ncbi request reprint Benefit associated with appropriate antibiotic treatment
    Leonard Leibovici
    Clin Infect Dis 45:1400; author reply 1401-2. 2007
  97. ncbi request reprint Chlamydia pneumoniae and acute coronary syndrome
    Mical Paul
    N Engl J Med 353:525-8; author reply 525-8. 2005
  98. doi request reprint Interventions for alleviating cancer-related dyspnea: a systematic review
    Irit Ben-Aharon
    Institute of Oncology, Davidoff Center, Rabin Medical Center Campus, 49100 Petah Tiqva, Israel
    J Clin Oncol 26:2396-404. 2008
    ..Dyspnea is one of the most distressing symptoms experienced by terminally ill cancer patients. This study aimed to evaluate the role of interventions for the palliation of dyspnea...