Keren Lasker

Summary

Affiliation: Tel Aviv University
Country: Israel

Publications

  1. pmc Inferential optimization for simultaneous fitting of multiple components into a CryoEM map of their assembly
    Keren Lasker
    Blavatnik School of Computer Science, Raymond and Beverly Sackler Faculty of Exact Sciences, Tel Aviv University, Tel Aviv 69978, Israel
    J Mol Biol 388:180-94. 2009
  2. ncbi request reprint EMatch: discovery of high resolution structural homologues of protein domains in intermediate resolution cryo-EM maps
    Keren Lasker
    School of Computer Science, Raymond and Beverly Sackler Faculty of Exact Sciences, Tel Aviv University, Israel
    IEEE/ACM Trans Comput Biol Bioinform 4:28-39. 2007
  3. pmc Determining macromolecular assembly structures by molecular docking and fitting into an electron density map
    Keren Lasker
    Raymond and Beverly Sackler Faculty of Exact Sciences, Blavatnik School of Computer Science, Tel Aviv University, Tel Aviv 69978, Israel
    Proteins 78:3205-11. 2010
  4. pmc EMatch: an efficient method for aligning atomic resolution subunits into intermediate-resolution cryo-EM maps of large macromolecular assemblies
    Oranit Dror
    School of Computer Science, Raymond and Beverly Sackler Faculty of Exact Sciences, Tel Aviv University, Tel Aviv 69978, Israel
    Acta Crystallogr D Biol Crystallogr 63:42-9. 2007
  5. pmc Conformational transitions in human translin enable nucleic acid binding
    Laura Perez-Cano
    Joint BSC IRB Research Programme in Computational Biology, Barcelona Supercomputing Center BSC, Jordi Girona 29, Barcelona 08034, Spain, Department of Biology, Technion Israel Institute of Technology, Haifa 32000, Israel, Blavatnik School of Computer Science, Raymond and Beverly Sackler Faculty of Exact Sciences, Tel Aviv University, Tel Aviv 69978, Israel, Bioinformatics Knowledge Unit, The Lorry I Lokey Interdisciplinary Center for Life Sciences and Engineering, Technion Israel Institute of Technology, Haifa 32000, Israel and Centre de Biochimie Structurale, INSERM U1054, CNRS UMR 5048, Universite Montpellier 1 and 2, F 34090 Montpellier, France
    Nucleic Acids Res 41:9956-66. 2013

Detail Information

Publications5

  1. pmc Inferential optimization for simultaneous fitting of multiple components into a CryoEM map of their assembly
    Keren Lasker
    Blavatnik School of Computer Science, Raymond and Beverly Sackler Faculty of Exact Sciences, Tel Aviv University, Tel Aviv 69978, Israel
    J Mol Biol 388:180-94. 2009
    ..A near-native configuration was usually found as the top-scoring model. Therefore, MultiFit can provide initial configurations for further refinement of many multicomponent assembly structures described by electron microscopy...
  2. ncbi request reprint EMatch: discovery of high resolution structural homologues of protein domains in intermediate resolution cryo-EM maps
    Keren Lasker
    School of Computer Science, Raymond and Beverly Sackler Faculty of Exact Sciences, Tel Aviv University, Israel
    IEEE/ACM Trans Comput Biol Bioinform 4:28-39. 2007
    ..The method is highly efficient and has been successfully validated on various simulated data. The strength of the method is demonstrated by a domain assembly of an experimental cryo-EM map of native GroEL at 6 A resolution...
  3. pmc Determining macromolecular assembly structures by molecular docking and fitting into an electron density map
    Keren Lasker
    Raymond and Beverly Sackler Faculty of Exact Sciences, Blavatnik School of Computer Science, Tel Aviv University, Tel Aviv 69978, Israel
    Proteins 78:3205-11. 2010
    ..The successful predictions and the increasing number of complexes being characterized by EM suggests that the CAPRI challenge could be extended to include docking-based modeling of macromolecular assemblies guided by EM...
  4. pmc EMatch: an efficient method for aligning atomic resolution subunits into intermediate-resolution cryo-EM maps of large macromolecular assemblies
    Oranit Dror
    School of Computer Science, Raymond and Beverly Sackler Faculty of Exact Sciences, Tel Aviv University, Tel Aviv 69978, Israel
    Acta Crystallogr D Biol Crystallogr 63:42-9. 2007
    ..The method recognizes and locates possible atomic resolution structural homologues of protein domains in the assembly. The strengths of EMatch are demonstrated on a cryo-EM map of native GroEL at 6 A resolution...
  5. pmc Conformational transitions in human translin enable nucleic acid binding
    Laura Perez-Cano
    Joint BSC IRB Research Programme in Computational Biology, Barcelona Supercomputing Center BSC, Jordi Girona 29, Barcelona 08034, Spain, Department of Biology, Technion Israel Institute of Technology, Haifa 32000, Israel, Blavatnik School of Computer Science, Raymond and Beverly Sackler Faculty of Exact Sciences, Tel Aviv University, Tel Aviv 69978, Israel, Bioinformatics Knowledge Unit, The Lorry I Lokey Interdisciplinary Center for Life Sciences and Engineering, Technion Israel Institute of Technology, Haifa 32000, Israel and Centre de Biochimie Structurale, INSERM U1054, CNRS UMR 5048, Universite Montpellier 1 and 2, F 34090 Montpellier, France
    Nucleic Acids Res 41:9956-66. 2013
    ..Our data thus provide a structural basis for the functions that translin performs in RNA metabolism and transport. ..