Ruth Koren

Summary

Affiliation: Tel Aviv University
Country: Israel

Publications

  1. pmc Hardship financing of healthcare among rural poor in Orissa, India
    Erika Binnendijk
    Institute of Health Policy and Management, Erasmus University Rotterdam, PO Box 1738, 3000 DR Rotterdam, The Netherlands
    BMC Health Serv Res 12:23. 2012
  2. ncbi request reprint Vitamin D receptor defects: the story of hereditary resistance to vitamin D
    Ruth Koren
    Felsenstein Medical Research Center, Department of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel Aviv University, Israel
    Pediatr Endocrinol Rev 3:470-5. 2006
  3. ncbi request reprint Calcitriol sensitizes colon cancer cells to H2O2-induced cytotoxicity while inhibiting caspase activation
    Ruth Koren
    Basil and Gerald Felsenstein Medical Research Center, Sackler Faculty of Medicine, Tel Aviv University, Rabin Medical Center, Beilinson Campus, Petah Tikva 49100, Israel
    J Steroid Biochem Mol Biol 101:151-60. 2006
  4. ncbi request reprint Synergistic anticancer activity of 1,25-dihydroxyvitamin D(3) and immune cytokines: the involvement of reactive oxygen species
    R Koren
    Department of Physiology and Pahrmacology, The Basil and Gerald Felsenstein Medical Research Center, Rabin Medical Center, Petah Tikva, Israel
    J Steroid Biochem Mol Biol 73:105-12. 2000
  5. ncbi request reprint Vitamin D is a prooxidant in breast cancer cells
    R Koren
    Basil and Gerald Felsenstein Medical Research Center, Rabin Medical Center, Petah Tikva, Israel
    Cancer Res 61:1439-44. 2001
  6. ncbi request reprint Vitamin D sensitizes breast cancer cells to the action of H2O2: mitochondria as a convergence point in the death pathway
    Gregory E Weitsman
    Basil and Gerald Felsenstein Medical Research Center, Sackler Faculty of Medicine, Tel Aviv University, Beilinson Campus, Petah Tikva 49100, Israel
    Free Radic Biol Med 39:266-78. 2005
  7. ncbi request reprint Vitamin D enhances caspase-dependent and -independent TNFalpha-induced breast cancer cell death: The role of reactive oxygen species and mitochondria
    Gregory E Weitsman
    Department of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    Int J Cancer 106:178-86. 2003
  8. ncbi request reprint The role of p38 MAP kinase in the synergistic cytotoxic action of calcitriol and TNF-alpha in human breast cancer cells
    Gregory E Weitsman
    Department of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    J Steroid Biochem Mol Biol 89:361-4. 2004
  9. doi request reprint The inflammatory response of keratinocytes and its modulation by vitamin D: the role of MAPK signaling pathways
    Mor Miodovnik
    Basil and Gerald Felsenstein Medical Research Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    J Cell Physiol 227:2175-83. 2012
  10. ncbi request reprint Two modes of ERK activation by TNF in keratinocytes: different cellular outcomes and bi-directional modulation by vitamin D
    Ester Ziv
    The Basil and Gerald Felsenstein Medical Research Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    J Cell Biochem 104:606-19. 2008

Collaborators

  • M Weinreb
  • A Ravid
  • Romy Zemel
  • E Fenig
  • C E Nemcovsky
  • E Golomb
  • E Zeldich
  • Gregory E Weitsman
  • Mor Miodovnik
  • M Dard
  • Uri A Liberman
  • Erika Binnendijk
  • Meital Gal-Tanamy
  • K Bahar-Shany
  • M Langberg
  • Ester Ziv
  • Carmela Rotem
  • T Diker-Cohen
  • Talia Diker-Cohen
  • G E Weitsman
  • Esther Ziv
  • David M Dror
  • Larisa Bachmetov
  • Arie Erman
  • Ran Tur-Kaspa
  • E Weinberg
  • C Rotem
  • Efrat Zuck
  • U A Liberman

Detail Information

Publications23

  1. pmc Hardship financing of healthcare among rural poor in Orissa, India
    Erika Binnendijk
    Institute of Health Policy and Management, Erasmus University Rotterdam, PO Box 1738, 3000 DR Rotterdam, The Netherlands
    BMC Health Serv Res 12:23. 2012
    ..We define hardship financing as having to borrow money with interest or to sell assets to pay out-of-pocket healthcare costs...
  2. ncbi request reprint Vitamin D receptor defects: the story of hereditary resistance to vitamin D
    Ruth Koren
    Felsenstein Medical Research Center, Department of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel Aviv University, Israel
    Pediatr Endocrinol Rev 3:470-5. 2006
    ..Interference with one or more of these steps results in the clinical syndrome of HVDRR...
  3. ncbi request reprint Calcitriol sensitizes colon cancer cells to H2O2-induced cytotoxicity while inhibiting caspase activation
    Ruth Koren
    Basil and Gerald Felsenstein Medical Research Center, Sackler Faculty of Medicine, Tel Aviv University, Rabin Medical Center, Beilinson Campus, Petah Tikva 49100, Israel
    J Steroid Biochem Mol Biol 101:151-60. 2006
    ..The sensitization of colon cancer cells to ROS-induced cytotoxicity may contribute to its assumed action as a chemopreventive agent and to its therapeutic potential alone or in combination with other anti-cancer modalities...
  4. ncbi request reprint Synergistic anticancer activity of 1,25-dihydroxyvitamin D(3) and immune cytokines: the involvement of reactive oxygen species
    R Koren
    Department of Physiology and Pahrmacology, The Basil and Gerald Felsenstein Medical Research Center, Rabin Medical Center, Petah Tikva, Israel
    J Steroid Biochem Mol Biol 73:105-12. 2000
    ..We conclude that 1,25(OH)(2)D(3) can act synergistically with anticancer cytokines present in the tumor milieu and that ROS plays a mediatory role in this interaction...
  5. ncbi request reprint Vitamin D is a prooxidant in breast cancer cells
    R Koren
    Basil and Gerald Felsenstein Medical Research Center, Rabin Medical Center, Petah Tikva, Israel
    Cancer Res 61:1439-44. 2001
    ....
  6. ncbi request reprint Vitamin D sensitizes breast cancer cells to the action of H2O2: mitochondria as a convergence point in the death pathway
    Gregory E Weitsman
    Basil and Gerald Felsenstein Medical Research Center, Sackler Faculty of Medicine, Tel Aviv University, Beilinson Campus, Petah Tikva 49100, Israel
    Free Radic Biol Med 39:266-78. 2005
    ..These findings indicate that calcitriol sensitizes breast cancer cells to ROS-induced death by affecting event(s) common to both caspase-dependent and -independent modes of cell death upstream to mitochondrial damage...
  7. ncbi request reprint Vitamin D enhances caspase-dependent and -independent TNFalpha-induced breast cancer cell death: The role of reactive oxygen species and mitochondria
    Gregory E Weitsman
    Department of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    Int J Cancer 106:178-86. 2003
    ..It is possible that the interaction of TNFalpha and calcitriol on the level of the mitochondria is the underlying mechanism responsible for the enhancement of TNFalpha-induced, ROS-mediated caspase-dependent and -independent cell death...
  8. ncbi request reprint The role of p38 MAP kinase in the synergistic cytotoxic action of calcitriol and TNF-alpha in human breast cancer cells
    Gregory E Weitsman
    Department of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    J Steroid Biochem Mol Biol 89:361-4. 2004
    ....
  9. doi request reprint The inflammatory response of keratinocytes and its modulation by vitamin D: the role of MAPK signaling pathways
    Mor Miodovnik
    Basil and Gerald Felsenstein Medical Research Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    J Cell Physiol 227:2175-83. 2012
    ....
  10. ncbi request reprint Two modes of ERK activation by TNF in keratinocytes: different cellular outcomes and bi-directional modulation by vitamin D
    Ester Ziv
    The Basil and Gerald Felsenstein Medical Research Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    J Cell Biochem 104:606-19. 2008
    ..It is possible that effects on the ERK cascade contribute to the effects of calcitriol and its synthetic analogs on cutaneous inflammation and keratinocyte proliferation...
  11. ncbi request reprint The role of reactive oxygen species in the anticancer activity of vitamin D
    Amiram Ravid
    Laboratory for Endocrine Immunology, Felsenstein Medical Research Center, Beilinson Campus, 49100 Petah Tikva, Israel
    Recent Results Cancer Res 164:357-67. 2003
    ....
  12. ncbi request reprint Vitamin D protects keratinocytes from apoptosis induced by osmotic shock, oxidative stress, and tumor necrosis factor
    Talia Diker-Cohen
    Department of Physiology and Pharmacology, Felsenstein Medical Research Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    Ann N Y Acad Sci 1010:350-3. 2003
    ..These results are in accordance with previous in vivo findings that vitamin D protects epidermal keratinocytes from apoptosis due to UV radiation or chemotherapy...
  13. ncbi request reprint Programmed cell death of stressed keratinocytes and its inhibition by vitamin D: the role of death and survival signaling pathways
    T Diker-Cohen
    Basil and Gerald Felsenstein Medical Research Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, 69978, Israel
    Apoptosis 11:519-34. 2006
    ..Since mimicking this effect by pharmacological inhibition resulted in the attenuation of caspase activation, we infer that these pathways are involved in keratinocyte protection by 1,25(OH)2D3...
  14. doi request reprint Upregulation of MMP-9 production by TNFalpha in keratinocytes and its attenuation by vitamin D
    K Bahar-Shany
    Basil and Gerald Felsenstein Medical Research Center, Tel Aviv University, Tel Aviv, Israel
    J Cell Physiol 222:729-37. 2010
    ..By down-regulating MMP-9 levels active vitamin D derivatives may attenuate deleterious effects due to excessive TNFalpha-induced proteolytic activity associated with cutaneous inflammation...
  15. ncbi request reprint Vitamin D inhibits the activation of stress-activated protein kinases by physiological and environmental stresses in keratinocytes
    A Ravid
    Basil and Gerald Felsenstein Medical Research Center, Sackler Faculty of Medicine, Tel Aviv University, Beilinson Campus, Petah Tikva 49100, Israel
    J Endocrinol 173:525-32. 2002
    ....
  16. ncbi request reprint Effects of senescence and citral on neuronal vacuolar degeneration in rat pelvic ganglia
    E Golomb
    Department of Pathology, Sackler Medical School, Tel Aviv University, Ramat Aviv, Israel
    Neurotoxicology 22:73-7. 2001
    ..This shows that environmental stimuli enhance age-related processes of vacuolar neuronal degeneration in PG, and may contribute to the dysfunction of pelvic organs in the elderly...
  17. ncbi request reprint Vitamin D enhances caspase-dependent and independent TNF-induced breast cancer cell death: the role of reactive oxygen species
    G E Weitsman
    Felsenstein Medical Research Center, Department of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    Ann N Y Acad Sci 1010:437-40. 2003
    ..We postulate that the interaction of TNF and calcitriol on the level of the mitochondria underlies the enhancement of TNF-induced, ROS-mediated caspase-dependent and -independent cell death...
  18. doi request reprint Vitamin D: an innate antiviral agent suppressing hepatitis C virus in human hepatocytes
    Meital Gal-Tanamy
    Molecular Hepatology Research Laboratory, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
    Hepatology 54:1570-9. 2011
    ..Importantly, the combination of vitamin D(3) or calcitriol and interferon-α synergistically inhibited viral production...
  19. ncbi request reprint Enamel matrix derivative stimulates human gingival fibroblast proliferation via ERK
    E Zeldich
    Department of Oral Biology, Tel Aviv University, Israel
    J Dent Res 86:41-6. 2007
    ..This study characterized the mitogenic effect of Emdogain on primary human gingival fibroblasts, its cooperation with serum growth factors, and the key mediatory role of the ERK cascade...
  20. doi request reprint Enamel matrix derivative induces the expression of tissue inhibitor of matrix metalloproteinase-3 in human gingival fibroblasts via extracellular signal-regulated kinase
    E Zeldich
    Department of Oral Biology, Goldschleger School of Dental Medicine, Tel Aviv University, Tel Aviv, Israel
    J Periodontal Res 45:200-6. 2010
    ..In the present study, the modulation of MMP and TIMP expression by EMD was investigated...
  21. doi request reprint Vitamin D protects keratinocytes from deleterious effects of ionizing radiation
    M Langberg
    The Basil and Gerald Felsenstein Medical Research Center, Sackler Faculty of Medicine, Tel Aviv University, Beilinson Campus, Rabin Medical Center, Petah Tikva 49100, Israel
    Br J Dermatol 160:151-61. 2009
    ..Calcitriol, the hormonally active vitamin D metabolite, protects keratinocytes from programmed cell death induced by various noxious stimuli...
  22. ncbi request reprint EGFR in Enamel Matrix Derivative-induced gingival fibroblast mitogenesis
    E Zeldich
    Department of Oral Biology, The Maurice and Gabriela Goldschleger School of Dental Medicine, Tel Aviv University, Tel Aviv, Israel
    J Dent Res 87:850-5. 2008
    ..Taken together, these results indicate that, at least in human gingival fibroblasts, EMD-induced ERK activation and proliferation are partially due to a Src-dependent, metalloproteinase-mediated transactivation of EGFR...
  23. ncbi request reprint Enamel matrix derivative protects human gingival fibroblasts from TNF-induced apoptosis by inhibiting caspase activation
    E Zeldich
    Department of Oral Biology, The Maurice and Gabriela Goldschleger School of Dental Medicine, Tel Aviv University, Tel Aviv, Israel
    J Cell Physiol 213:750-8. 2007
    ....