A D Korczyn

Summary

Affiliation: Tel Aviv University
Country: Israel

Publications

  1. ncbi request reprint Mixed dementia--the most common cause of dementia
    Amos D Korczyn
    Tel Aviv University Medical School, Ramat Aviv 69978, Israel
    Ann N Y Acad Sci 977:129-34. 2002
  2. ncbi request reprint Muscarinic M(1) agonists in the treatment of Alzheimer's disease
    A D Korczyn
    Sieratzki Chair of Neurology, Sackler School of Medicine, Tel Aviv University, Ramat Aviv 69978, Israel
    Expert Opin Investig Drugs 9:2259-67. 2000
  3. ncbi request reprint Emerging therapies in the pharmacological treatment of Parkinson's disease
    Amos D Korczyn
    Department of Neurology, Sackler School of Medicine, Tel Aviv University Medical School, Ramat Aviv, Israel
    Drugs 62:775-86. 2002
  4. doi request reprint The amyloid cascade hypothesis
    Amos D Korczyn
    Sieratzki Chair of Neurology, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
    Alzheimers Dement 4:176-8. 2008
  5. ncbi request reprint Drug trials in dementia: challenging ethical dilemmas
    Amos D Korczyn
    The Sieratzki Chair of Neurology, Sackler School of Medicine, Tel Aviv University, Ramat Aviv, Israel
    Curr Alzheimer Res 4:468-72. 2007
  6. ncbi request reprint Computerized methods in the assessment and prediction of dementia
    Amos D Korczyn
    Sieratzki Chair of Neurology, Sackler Faculty of Medicine, Tel Aviv University, Ramat Aviv, Israel
    Curr Alzheimer Res 4:364-9. 2007
  7. ncbi request reprint The prevention of the dementia epidemic
    Amos D Korczyn
    The Sieratzki Chair of Neurology, Tel Aviv University Medical School, Ramat Aviv 69978, Israel
    J Neurol Sci 257:2-4. 2007
  8. ncbi request reprint The complex nosological concept of vascular dementia
    Amos D Korczyn
    Tel Aviv University Medical School, Ramat Aviv 69978, Israel
    J Neurol Sci 203:3-6. 2002
  9. ncbi request reprint Dementia in Parkinson's disease
    A D Korczyn
    Sackler Faculty of Medicine, Tel Aviv University Medical School, Ramat Aviv, Israel
    J Neurol 248:III1-4. 2001
  10. ncbi request reprint The underdiagnosis of the vascular contribution to dementia
    Amos D Korczyn
    The Sieratzki Chair of Neurology, Tel Aviv University Medical School, Ramat Aviv 69978, Israel
    J Neurol Sci 229:3-6. 2005

Detail Information

Publications119 found, 100 shown here

  1. ncbi request reprint Mixed dementia--the most common cause of dementia
    Amos D Korczyn
    Tel Aviv University Medical School, Ramat Aviv 69978, Israel
    Ann N Y Acad Sci 977:129-34. 2002
    ..This surprising finding highlights the importance of mixed vascular-degenerative dementia as a disorder that has to be properly defined and has important implications on prevention and treatment...
  2. ncbi request reprint Muscarinic M(1) agonists in the treatment of Alzheimer's disease
    A D Korczyn
    Sieratzki Chair of Neurology, Sackler School of Medicine, Tel Aviv University, Ramat Aviv 69978, Israel
    Expert Opin Investig Drugs 9:2259-67. 2000
    ..Several reasons might account for this failure, which are discussed, as well as the prospects for the future...
  3. ncbi request reprint Emerging therapies in the pharmacological treatment of Parkinson's disease
    Amos D Korczyn
    Department of Neurology, Sackler School of Medicine, Tel Aviv University Medical School, Ramat Aviv, Israel
    Drugs 62:775-86. 2002
    ..One of the recent trends is early employment of dopamine agonists. Additional efforts are being directed towards protecting and restoring dopamine neurons. Novel therapies acting on non-dopaminergic systems are also being researched...
  4. doi request reprint The amyloid cascade hypothesis
    Amos D Korczyn
    Sieratzki Chair of Neurology, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
    Alzheimers Dement 4:176-8. 2008
    ..This article looks critically at the basis of the "amyloid cascade hypothesis" to conclude that there are many issues that need to be resolved since they are inconsistent with the hypothesis...
  5. ncbi request reprint Drug trials in dementia: challenging ethical dilemmas
    Amos D Korczyn
    The Sieratzki Chair of Neurology, Sackler School of Medicine, Tel Aviv University, Ramat Aviv, Israel
    Curr Alzheimer Res 4:468-72. 2007
    ..It would be helpful and justified to enable subjects to continue in the study in an open-label design in this situation, once they sign a suitable informed consent. A no-fault insurance could be provided to the patient in this situation...
  6. ncbi request reprint Computerized methods in the assessment and prediction of dementia
    Amos D Korczyn
    Sieratzki Chair of Neurology, Sackler Faculty of Medicine, Tel Aviv University, Ramat Aviv, Israel
    Curr Alzheimer Res 4:364-9. 2007
    ....
  7. ncbi request reprint The prevention of the dementia epidemic
    Amos D Korczyn
    The Sieratzki Chair of Neurology, Tel Aviv University Medical School, Ramat Aviv 69978, Israel
    J Neurol Sci 257:2-4. 2007
    ..Interestingly, attention to risk factors, such as hypertension, coronary artery disease, hyperlipidemia and smoking could reduce or delay the incidence of dementia, both vascular and AD...
  8. ncbi request reprint The complex nosological concept of vascular dementia
    Amos D Korczyn
    Tel Aviv University Medical School, Ramat Aviv 69978, Israel
    J Neurol Sci 203:3-6. 2002
    ..These unexpected findings highlight the importance of mixed vascular-degenerative dementia as a disorder which has to be properly defined and has important implications on prevention and treatment...
  9. ncbi request reprint Dementia in Parkinson's disease
    A D Korczyn
    Sackler Faculty of Medicine, Tel Aviv University Medical School, Ramat Aviv, Israel
    J Neurol 248:III1-4. 2001
    ..We have treated several patients with the cholinesterase inhibitor rivastigmine which produced gratifying results. Future studies should define the exact role of this agent in the treatment of the dementia of PD...
  10. ncbi request reprint The underdiagnosis of the vascular contribution to dementia
    Amos D Korczyn
    The Sieratzki Chair of Neurology, Tel Aviv University Medical School, Ramat Aviv 69978, Israel
    J Neurol Sci 229:3-6. 2005
    ..These surprising findings highlight the importance of mixed vascular-degenerative dementia as a disorder that has to be properly defined...
  11. ncbi request reprint Dementia with Lewy bodies
    Amos D Korczyn
    Sieratzki Chair of Neurology, Tel Aviv University Medical School, Ramat Aviv 69978, Tel Aviv, Israel
    J Neurol Sci 248:3-8. 2006
    ....
  12. ncbi request reprint Rotigotine transdermal system for perioperative administration
    A D Korczyn
    Tel Aviv University Medical School, Ramat Aviv, Israel
    J Neural Transm 114:219-21. 2007
    ..Perioperative administration of rotigotine appeared to be feasible and efficacious. No safety issues emerged from these observations...
  13. ncbi request reprint Management of sleep problems in Parkinson's disease
    Amos D Korczyn
    Sieratzki Chair of Neurology, Tel Aviv University Medical School, Ramat Aviv 69978, Israel
    J Neurol Sci 248:163-6. 2006
    ..These may respond to atypical neuroleptics. Clozapine and quetiapine are particularly useful, but require attention to possible adverse effects...
  14. ncbi request reprint Risk factors for dementia, depression and psychosis in long-standing Parkinson's disease
    N Giladi
    Department of Neurology, Tel Aviv Medical Center, Sackler School of Medicine, Tel Aviv University, Israel
    J Neural Transm 107:59-71. 2000
    ..To study the relationships between clinical features of Parkinson's disease (PD) and the development of dementia, depression or psychosis in patients with long-standing disease...
  15. ncbi request reprint Freezing of gait in patients with advanced Parkinson's disease
    N Giladi
    Department of Neurology, Tel-Aviv Medical Center, Sackler Faculty of Medicine, Tel-Aviv University, Israel
    J Neural Transm 108:53-61. 2001
    ..002), early morning foot dystonia (p < 0.003) and significant postural instability (p < 0.0005). CONCLUSION: FOG is a common symptom in advanced PD. It is mainly related to disease progression and levodopa treatment...
  16. ncbi request reprint Hyperactivity in a mouse model of the antiphospholipid syndrome
    A Katzav
    Department of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel Aviv, Israel
    Lupus 10:496-9. 2001
    ..023) and higher number of stairs climbed (P < 0.019) by the mice in 3 min. This simple test demonstrated that experimental APS animals are significantly hyperactive and may serve as a marker for CNS involvement in this model...
  17. doi request reprint Subjective memory complaints in elders: depression, anxiety, or cognitive decline?
    Y Balash
    Sackler School of Medicine, Tel Aviv University, Israel
    Acta Neurol Scand 127:344-50. 2013
    ..To study the association of subjective memory complaints (SMC) with affective state and cognitive performance in elders...
  18. doi request reprint The role of apolipoprotein E polymorphisms in levodopa-induced dyskinesia
    I Molchadski
    Chaim Sheba Medical Center, Tel Hashomer, Ramat Gan, Tel Aviv, Israel
    Acta Neurol Scand 123:117-21. 2011
    ..To determine the relationship between apolipoprotein E (APOE) polymorphisms to the time to appearance of levodopa-induced dyskinesia (LID) in patients with Parkinson's disease...
  19. ncbi request reprint Rivastigmine (Exelon) for dementia in patients with Parkinson's disease
    N Giladi
    Department of Neurology, Tel Aviv Sourasky Medical Center, Israel
    Acta Neurol Scand 108:368-73. 2003
    ..To study the efficacy of cholinesterase inhibitors in the treatment of dementia in patients with Parkinson's disease (PD)...
  20. doi request reprint Cognitive assessment in proximity to acute ischemic stroke/transient ischemic attack: comparison of the montreal cognitive assessment test and mindstreams computerized cognitive assessment battery
    L Shopin
    Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
    Dement Geriatr Cogn Disord 36:36-42. 2013
    ....
  21. ncbi request reprint Clinical characteristics of neuroleptic-induced parkinsonism
    S Hassin-Baer
    Department of Neurology, Tel-Aviv Medical Center, Israel
    J Neural Transm 108:1299-308. 2001
    ..NIP develops unrelated to duration of neuroleptic treatment or age of the patient, suggesting an individual predisposition to blockage of the dopaminergic receptors...
  22. ncbi request reprint Prevalence of Alzheimer's type dementia in an elderly Arab population
    A Bowirrat
    Department of Neurology, Sackler Faculty of Medicine, Tel Aviv University, Israel
    Eur J Neurol 8:119-23. 2001
    ..While the results support a protective effect of schooling against the development of dementia, other factors (e.g. genetic) must be sought to explain this high frequency...
  23. doi request reprint Cerebral vasomotor reactivity and dementia after ischemic stroke
    Alexander Y Gur
    Stroke Unit, Department of Neurology, Tel Aviv Sourasky Medical Center and the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    Acta Neurol Scand 122:383-8. 2010
    ..We compared cerebral vasomotor reactivity (VMR) assessed in the acute phase of ischemic stroke (IS) in patients with and without PSD. VMR was also assessed and compared in demented and non-demented patients in the late phase of IS...
  24. ncbi request reprint EEG changes during long-term treatment with donepezil in Alzheimer's disease patients
    E A Kogan
    EEG and Epilepsy Unit, Department of Neurology, Tel-Aviv Sourasky Medical Center, Israel
    J Neural Transm 108:1167-73. 2001
    ..The differences in qEEG in patients with different stages of dementia under donepezil treatment may be related to different compensatory capacities due to structural and functional brain disturbances...
  25. ncbi request reprint Possible remote functional reorganization in left temporal lobe epilepsy
    S Kipervasser
    EEG and Epilepsy Unit, Department of Neurology, Wohl Institute for Advanced Imaging, Tel Aviv, Israel
    Acta Neurol Scand 117:324-31. 2008
    ..To provide functional magnetic resonance imaging-based insight into the impact of left temporal lobe epilepsy (TLE) on language-related functional re-organization...
  26. ncbi request reprint A 3-year randomized trial of ropinirole and bromocriptine in early Parkinson's disease. The 053 Study Group
    A D Korczyn
    Department of Neurology, Sackler Faculty of Medicine, Tel Aviv University, Israel
    Neurology 53:364-70. 1999
    ..To compare the long-term efficacy and safety of ropinirole with bromocriptine over 3 years in patients with early PD with limited or no previous dopaminergic therapy...
  27. doi request reprint Vasomotor reactivity as a predictor for syncope in patients with orthostatism
    A Y Gur
    The Department of Neurology, Barzilai Medical Center, Tel Aviv, Israel
    Acta Neurol Scand 126:32-6. 2012
    ..Cerebral autoregulation status can be determined by assessing cerebral vasomotor reactivity (VMR). We assessed and compared VMR in patients with OH with and without syncope...
  28. ncbi request reprint The value of muscle exercise in patients with amyotrophic lateral sclerosis
    V E Drory
    ALS Clinic, Department of Neurology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
    J Neurol Sci 191:133-7. 2001
    ..Our results show that a regular moderate physical exercise program has a short-lived positive effect on disability in ALS patients and should be recommended...
  29. ncbi request reprint Physically traumatic events in patients with epilepsy compared with non-epileptic subjects
    M Y Neufeld
    EEG and Epilepsy Unit, Department of Neurology, Tel Aviv Sourasky Medical Center, 6 Weizmann St, Tel Aviv 64239, Israel
    Seizure 9:595-7. 2000
    ..We conclude that physically traumatic events not related to seizures are fewer among patients with epilepsy with and without seizures compared with controls, probably because of increased cautiousness...
  30. ncbi request reprint Autonomic dysfunction in experimental autoimmune neuritis: heart rate
    N Wang
    Department of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    J Neurol Sci 184:183-8. 2001
    ..m.) and 10 tachycardia (>400 b.p.m.) (P<0.01, F-test). sHR in EAN rats was significantly lower (P<0.01), suggesting sympathetic system impairment. These findings may serve as a basis for testing treatments of ANS dysfunction in EAN...
  31. pmc Antiphospholipid antibodies bind ATP: a putative mechanism for the pathogenesis of neuronal dysfunction
    J Chapman
    Department of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel Aviv University, Ramat Aviv 69978, Israel
    Clin Dev Immunol 12:175-80. 2005
    ..We conclude that aPL IgG bind ATP, probably through beta32-GPI. This binding could interfere with the normal extracellular function of ATP and similar neurotransmitters...
  32. ncbi request reprint The diagnostic aid of routine EEG findings in patients presenting with a presumed first-ever unprovoked seizure
    M Y Neufeld
    EEG and Epilepsy Unit, Department of Neurology, Tel Aviv Sourasky Medical Center, 6 Weizmann St, 6439, Tel Aviv, Israel
    Epilepsy Res 42:197-202. 2000
    ..The EEG is particularly helpful in supporting the epileptic nature of the event in younger patients and in those with seizures of unknown origin...
  33. pmc Treatment of MRL/lpr mice, a genetic autoimmune model, with the Ras inhibitor, farnesylthiosalicylate (FTS)
    A Katzav
    Department of Physiology, Sackler Faculty of Medicine, Tel Aviv University, Ramat Aviv, Israel
    Clin Exp Immunol 126:570-7. 2001
    ..These findings indicate that modulation of Ras activation has a significant impact on the MRL/lpr model and may represent a new therapeutic approach for the treatment of systemic autoimmune diseases such as SLE and APS...
  34. ncbi request reprint Antiparkinsonian medication is not a risk factor for the development of hallucinations in Parkinson's disease
    D Merims
    Movement Disorders Unit, Department of Neurology, Tel Aviv Sourasky Medical Center, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
    J Neural Transm 111:1447-53. 2004
    ..Accumulating evidence suggests the existence of other risk factors for psychosis in PD. Aims. To evaluate the contribution of the drug profile of patients with PD to emergence of hallucinations...
  35. pmc Quantitative anal sphincter EMG in multisystem atrophy and 100 controls
    R Gilad
    Department of Neurology, Wolfson Medical Center, Holon 58100, Israel
    J Neurol Neurosurg Psychiatry 71:596-9. 2001
    ..To evaluate data of quantitative anal sphincter EMG in normal controls and to compare them with patients with multiple system atrophy (MSA)...
  36. doi request reprint Biomarkers for evaluation of clinical efficacy of multipotential neuroprotective drugs for Alzheimer's and Parkinson's diseases
    Ilan Halperin
    Tel Aviv Sourasky Medical Center, Department of Neurology, Memory Clinic, Tel Aviv 64239, Israel
    Neurotherapeutics 6:128-40. 2009
    ....
  37. pmc Evoked potential studies in the antiphospholipid syndrome: differential diagnosis from multiple sclerosis
    D Paran
    Department of Rheumatology, Tel Aviv Sourasky Medical Centre, Sackler Faculty of Medicine, Tel Aviv University, Israel
    Ann Rheum Dis 65:525-8. 2006
    ..The CNS manifestations of the antiphospholipid syndrome (APS) can mimic multiple sclerosis both clinically and radiologically...
  38. doi request reprint Microembolism, silent brain infarcts and dementia
    I Goldberg
    Department of Neurology, Hadassah Medical Center and Faculty of Medicine, Hebrew University of Jerusalem, Israel
    J Neurol Sci 322:250-3. 2012
    ..The role of transcranial Doppler as an objective tool for detecting and quantifying microemboli is discussed in light of recent clinical evidence...
  39. ncbi request reprint EEG and topographic frequency analysis in common and classic migraine
    M Y Neufeld
    Department of Neurology, Tel-Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel-Aviv University, Israel
    Headache 31:232-6. 1991
    ..They may suggest some difference in the posterior background activity in the EEG in migraine patients as compared to the controls, but are not useful in differentiating migraine from non-migraine patients...
  40. ncbi request reprint Recruitment rate to drug trials for dementia of the Alzheimer type
    T A Treves
    Department of Neurology, Sourasky Medical Center, Tel Aviv, Israel
    Alzheimer Dis Assoc Disord 14:209-11. 2000
    ..Further, the high selection may limit the generalizability of the results of such studies...
  41. ncbi request reprint Parkin mutation associated parkinsonism and cognitive decline, comparison to early onset Parkinson's disease
    B R Benbunan
    Movement Disorders Unit, Department of Neurology, Tel Aviv Sourasky Medical Center, Tel Aviv University, Tel Aviv, Israel
    J Neural Transm 111:47-57. 2004
    ..Patients with Parkinson's disease (PD) have cognitive changes resulting, presumably, from a progressive disruption of the functional integrity of frontostriatal circuitry...
  42. ncbi request reprint Effects of rivastigmine on the quantitative EEG in demented Parkinsonian patients
    N Fogelson
    Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    Acta Neurol Scand 107:252-5. 2003
    ..Quantitative electroencephalogram (qEEG) can be used to measure the effects of drugs on the brain. We studied the effects of rivastigmine on the qEEG in Parkinson's disease (PD) patients with dementia...
  43. ncbi request reprint Cold pressor test in tetraplegia and paraplegia suggests an independent role of the thoracic spinal cord in the hemodynamic responses to cold
    A Catz
    The Spinal Department, Loewenstein Rehabilitation Hospital, Raanana, Israel
    Spinal Cord 46:33-8. 2008
    ..Cold application to the hand (CAH) is associated in healthy people with increase in heart rate (HR) and blood pressure (BP)...
  44. ncbi request reprint High b value q-space-analyzed diffusion MRI in vascular dementia: a preliminary study
    Y Assaf
    Wohl Institute for Advanced Imaging, Tel Aviv Sourasky Medical Center, Tel Aviv 64239, Israel
    J Neurol Sci 203:235-9. 2002
    ..This technique, therefore, might serve as a better indication for the extensive nerve fiber loss in the white matter that is caused by vascular disease...
  45. ncbi request reprint Prion diseases
    A D Korczyn
    Sackler School of Medicine, Tel Aviv University, Ramat Aviv, Israel
    Curr Opin Neurol 10:273-81. 1997
    ..The mechanisms underlying the evolution of the disease, as well as the species barrier are better understood...
  46. ncbi request reprint Neuronal-binding antibodies from patients with antiphospholipid syndrome induce cognitive deficits following intrathecal passive transfer
    Y Shoenfeld
    Department of Medicine B and Research Center for Autoimmune Diseases, Sheba MedicalCenter, Tel Hashomer, Israel
    Lupus 12:436-42. 2003
    ..These results support the hypothesis that aPL that gain access to the central nervous system may play a direct role in the pathogenesis of neurological manifestations of APS...
  47. ncbi request reprint A novel mutation of presenilin 1 in familial Alzheimer's disease in Israel detected by denaturing gradient gel electrophoresis
    H Reznik-Wolf
    Oncogenetics Unit, Chaim Sheba Medical Center, Tel Hashomer, Israel
    Hum Genet 98:700-2. 1996
    ..These results also demonstrate that DGGE can be used effectively to screen for mutations within this gene...
  48. ncbi request reprint Effect of rivastigmine on tremor in patients with Parkinson's disease and dementia
    Tanya Y Gurevich
    Tel Aviv Medical Center, Department of Neurology, Movement Disorders Unit, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    Mov Disord 21:1663-6. 2006
    ..08 +/- 0.03 xg at baseline; 0.12 +/- 0.02 xg at Week 12 of treatment, P = 0.02). Left-hand tremor amplitude did not change. Rivastigmine caused only slight worsening of tremor in demented PD patients, while improving cognition...
  49. ncbi request reprint White matter changes in multiple sclerosis: correlation of q-space diffusion MRI and 1H MRS
    Yaniv Assaf
    Functional Brain Imaging Laboratory, Tel Aviv Sourasky Medical Center, Tel Aviv 64239, Israel
    Magn Reson Imaging 23:703-10. 2005
    ..More specifically, we aimed at evaluating the ability of this methodology to identify tissue damage in the so-called normal-appearing white matter (NAWM)...
  50. doi request reprint Parkinson's disease: before the motor symptoms and beyond
    Amos D Korczyn
    Tel Aviv University Medical School, Ramat Aviv, Israel
    J Neurol Sci 289:2-6. 2010
    ..We review those manifestations and their contribution to the clarification of the pathophysiologic processes of PD, and discuss the implications for treatment of the disease...
  51. doi request reprint Vascular contribution to dementia in Parkinson's disease
    Amos D Korczyn
    Sackler School of Medicine, Tel Aviv University, IL 69978 Ramat Aviv, Israel
    Neurodegener Dis 7:127-30. 2010
    ..This article discusses the possible contribution of vascular factors to the cognitive impairment in Parkinson's disease and its implication for the management...
  52. doi request reprint 2nd World congress on controversies in neurology
    Amos D Korczyn
    Sieratzki Chair of Neurology, Tel Aviv University Medical School, Ramat Aviv, Tel Aviv, Israel
    Expert Rev Neurother 9:317-8. 2009
    ..Several debates were held between opposing leaders in the fields of multiple sclerosis, stroke, Parkinson's disease, dementia, epilepsy and headache...
  53. doi request reprint Depression and dementia
    Amos D Korczyn
    Tel Aviv University Medical School, Sieratzki Chair of Neurology, Ramat Aviv 69978, Israel
    J Neurol Sci 283:139-42. 2009
    ..Here we review the complex relationships between dementia and depression and suggest that excessive release of corticosteroids may have a neurotoxic effects...
  54. ncbi request reprint Prevalence and clinical features of dementia associated with the antiphospholipid syndrome and circulating anticoagulants
    Joab Chapman
    Department of Neurology, Tel Aviv Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Israel
    J Neurol Sci 203:81-4. 2002
    ..CAC-positive APS patients seem to be at risk for developing dementia with age, suggesting a pathogenic role for prolonged exposure to elevated aPL...
  55. pmc Is dementia preventable?
    Amos D Korczyn
    Tel Aviv University Medical School, Ramat Aviv, Tel Aviv, Israel
    Dialogues Clin Neurosci 11:213-6. 2009
    ....
  56. doi request reprint Antiphospholipid syndrome induction exacerbates a transgenic Alzheimer disease model on a female background
    Aviva Katzav
    Department of Neurology and Joseph Sagol Neuroscience Center, Sheba Medical Center, Tel Hashomer, 52621, Israel
    Neurobiol Aging 32:272-9. 2011
    ..The results indicate a significant interaction between APP genotype and the induction of APS on a female background. The mechanisms involved may also be important in human APS-AD co-morbidity...
  57. doi request reprint Is vascular cognitive impairment a useful concept?
    Amos D Korczyn
    Tel Aviv University Medical School, Ramat Aviv 69978, Israel
    J Neurol Sci 299:2-4. 2010
    ....
  58. ncbi request reprint The effects of APOE genotype on age at onset and progression of neurodegenerative diseases
    J Chapman
    Department of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel Aviv University, Israel
    Neurology 57:1482-5. 2001
    ..Early diagnosis facilitates the measurement of effects on disease progression rate, whereas late diagnosis results in a marked effect of APOE genotype on disease onset...
  59. ncbi request reprint Incidence of dementia in patients with subjective memory complaints
    T A Treves
    Department of Neurology, Rabin Medical Center, Petah Tikva 49100, Israel
    Int Psychogeriatr 17:265-73. 2005
    ..The risk of developing dementia by elderly patients with only subjective memory complaints (SMC) is unclear. Our objective was to assess the prognosis of such patients regarding subsequent development of dementia...
  60. ncbi request reprint Postmeningitis headache
    M Y Neufeld
    Department of Neurology, Sourasky Medical Center, Tel Aviv University, Tel Aviv, Israel
    Headache 39:132-4. 1999
    ..We conclude that there is an association between meningitis, either bacterial or aseptic, and subsequent persistent recurrent migrainous or nonmigrainous headache...
  61. ncbi request reprint The use of intravenous immunoglobulin as maintenance therapy in myasthenia gravis
    O Hilkevich
    Department of Neurology, Tel Aviv University, Tel Aviv, Israel
    Clin Neuropharmacol 24:173-6. 2001
    ..There were no serious side effects related to intravenous immunoglobulin. These results suggest that intravenous immunoglobulin maintenance therapy is a valid modality in patients with MG...
  62. ncbi request reprint Cortical lesions associated with transient neurological symptoms - not always a matter of cause and effect
    S Kipervasser
    EEG and Epilepsy Unit, Department of Neurology, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    Eur J Neurol 10:721-5. 2003
    ..Therefore, even in the presence of a confirmed brain lesion, the presenting paroxysmal events may be of a non-organic origin and should not necessarily be assumed to be caused by the concomitantly existing structural abnormality...
  63. ncbi request reprint Serial EEG recordings following intrathecal metrizamide administration
    V E Drory
    Department of Neurology, Tel Aviv Medical Center, Israel
    Clin Electroencephalogr 20:202-8. 1989
    ..The causes inducing these time-related disturbances are discussed, as compared to pharmacokinetics of intrathecally administered metrizamide...
  64. ncbi request reprint Cerebral vasomotor reactivity of patients with acute ischemic stroke: Cortical versus subcortical infarcts: an Israeli-Turkish collaborative study
    Alexander Y Gur
    Stroke Unit of the Department of Neurology, Tel Aviv Sourasky Medical Center and the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    J Neurol Sci 257:121-5. 2007
    ..Cerebral hemodynamic features of patients with different types of acute ischemic stroke are still obscure. We compared cerebral vasomotor reactivity (VMR) in acute cortical (CI) and subcortical (SI) brain infarcts...
  65. ncbi request reprint Fasting headache, weight loss, and dehydration
    A Mosek
    Department of Neurology, Sourasky Medical Center, Tel Aviv, Israel
    Headache 39:225-7. 1999
    ..This small difference was not statistically significant. We conclude that dehydration, as reflected by acute weight loss, is an unlikely cause of headache during a single day of fasting. The mechanism of fasting headache remains unclear...
  66. ncbi request reprint R-R interval variation in Parkinson's disease and multiple system atrophy
    T Yu Gurevich
    Department of Neurology, Tel Aviv Sourasky Medical Center, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
    Acta Neurol Scand 109:276-9. 2004
    ..To investigate whether the cardiac R-R interval variation (RRIV) is of value in differentiating patients with Parkinson's disease (PD) from multiple system atrophy (MSA)...
  67. ncbi request reprint Dosing with ropinirole in a clinical setting
    A D Korczyn
    Sieratzki Chair of Neurology, Tel Aviv University, Tel Aviv, Israel
    Acta Neurol Scand 106:200-4. 2002
    ..To determine the optimal dose of ropinirole (ReQuip) for treatment of early Parkinson's disease (PD)...
  68. ncbi request reprint Quantitative measurements of mouse brain thrombin-like and thrombin inhibition activities
    O Beilin
    Department of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 69978 Israel
    Neuroreport 12:2347-51. 2001
    ..2 mU thrombin/mg brain tissue. The present study offers a simple and reliable method for measuring total thrombin inhibitory activity in brain...
  69. ncbi request reprint Naproxen sodium versus ergotamine tartrate in the treatment of acute migraine attacks
    T A Treves
    Department of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel Aviv University Ramat Aviv, Israel
    Headache 32:280-2. 1992
    ....
  70. ncbi request reprint Oculopharyngeal MD among Bukhara Jews is due to a founder (GCG)9 mutation in the PABP2 gene
    S C Blumen
    Department of Neurology, Hillel Yaffe Medical Center, Hadera, Israel
    Neurology 55:1267-70. 2000
    ..To determine whether all cases of oculopharyngeal muscular dystrophy (OPMD) among Bukhara Jews share the same founder mutation...
  71. ncbi request reprint Plasma homocysteine, vitamin B12 and folate in Alzheimer's patients and healthy Arabs in Israel
    E H Mizrahi
    Department of Geriatric Medicine, Chaim Sheba Medical Center, affiliated to the Tel Aviv University, Sackler School of Medicine, Tel Hashomer, Israel
    J Neurol Sci 227:109-13. 2004
    ..There was not a significant association between plasma tHcy, B12 and folate levels in controls or AD patients. High levels of tHcy may suggest the need for folate and vitamin B12 supplementation in this population...
  72. ncbi request reprint Ropinirole in Gilles de la Tourette syndrome
    Marietta H Anca
    Department of Neurology, Tel Aviv Medical Center, and the Sieratzki Chair of Neurology, Sackler Faculty of Medicine, Tel Aviv University, Israel
    Neurology 62:1626-7. 2004
    ..All patients completed the study, and most showed an improvement in their tics during treatment. Low-dose ropinirole may improve the motor features in GdlT, but further controlled studies are necessary...
  73. ncbi request reprint Rotigotine transdermal patch in early Parkinson's disease: a randomized, double-blind, controlled study versus placebo and ropinirole
    Nir Giladi
    Movement Disorders Unit, Department of Neurology, Tel Aviv Sourasky Medical Center, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
    Mov Disord 22:2398-404. 2007
    ..Application-site reactions were predominantly mild or moderate in intensity. In conclusion, the rotigotine transdermal patch represents an effective and safe option for the treatment of patients with early Parkinson's disease...
  74. doi request reprint Modeling the dementia epidemic
    T A Treves
    Memory Disorders Clinic, Rabin Medical Center, Petach Tikva, Israel
    CNS Neurosci Ther 18:175-81. 2012
    ....
  75. ncbi request reprint Behavioral and cognitive deficits occur only after prolonged exposure of mice to antiphospholipid antibodies
    S Shrot
    Department of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel Aviv University, Israel
    Lupus 11:736-43. 2002
    ..The mechanism involved in these CNS manifestations remains to be elucidated...
  76. ncbi request reprint The assessment of radiating low back pain by thermal sensory testing
    A Mosek
    Pain Control Unit, Sourasky Medical Center, Tel Aviv, Israel
    Eur J Pain 5:347-51. 2001
    ..Thermal testing should be considered among the testing modalities that are capable of demonstrating objective findings in patients with radiating low back pain...
  77. ncbi request reprint Sound lateralization and interaural discrimination. Effects of brainstem infarcts and multiple sclerosis lesions
    M Furst
    Department of Electrical Engineering Systems, Faculty of Engineering, Tel Aviv University, Tel Aviv, Israel
    Hear Res 143:29-42. 2000
    ..These results suggest that neural processing of binaural stimuli is multilevel and begins with independent interaural time and level analyzers in the caudal pons...
  78. ncbi request reprint Subdivision of essential tremor patients according to physiologic characteristics
    D Golan
    Movement Disorders Unit, Department of Neurology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
    Acta Neurol Scand 109:393-7. 2004
    ..To test the effect of different forearm postures on tremor characteristics. We hypothesized that changes in tremor characteristics in relation to posture can subclassify essential tremor (ET) patients...
  79. ncbi request reprint Cerebral vasomotor reactivity in Parkinson's disease, multiple system atrophy and pure autonomic failure
    Tanya Gurevich
    Neurology Department, Tel Aviv Medical Center, Israel Sieratzki Chair of Neurology, Tel Aviv University, Israel
    J Neurol Sci 243:57-60. 2006
    ..We conclude that BFV is normal in PD, MSA and PAF and that the VMR, as investigated by TCD and the Diamox test, did not disclose differences in cerebral vasomotor responses between these conditions...
  80. doi request reprint Smoking and tea consumption delay onset of Parkinson's disease
    Boris Kandinov
    Department of Physiology and Pharmacology, Tel Aviv University, Tel Aviv, Israel
    Parkinsonism Relat Disord 15:41-6. 2009
    ..7 years (p<0.01). Coffee consumption exceeding 3 cups per day advanced the age of PD onset by 4.8 years (p=0.03). Thus, tea consumption and smoking can delay the age of PD onset, while coffee drinking may have the opposite effect...
  81. ncbi request reprint The effect of cigarette smoking, tea, and coffee consumption on the progression of Parkinson's disease
    Boris Kandinov
    Department of Physiology and Pharmacology, Tel Aviv University, Israel
    Parkinsonism Relat Disord 13:243-5. 2007
    ..We found that disease progression was not affected by cigarette smoking, tea or coffee consumption. The present study suggests that these variables do not have a disease modifying effect in already diagnosed PD patients...
  82. ncbi request reprint Inhibition of ras by farnesylthiosalicylate significantly reduces the levels of autoantibodies in two animal models of the antiphospholipid syndrome
    Aviva Katzav
    Dept of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel Aviv, Israel
    Immunobiology 207:47-50. 2003
    ..Antiphospholipid antibodies (aPL) are a heterogeneous group of antibodies detected in patients with antiphospholipid syndrome (APS), which is associated with thrombosis, pregnancy losses, and thrombocytopenia...
  83. ncbi request reprint Quality of sexual life in Parkinson's disease
    O Moore
    The Movement Disorders Unit, Department of Neurology, Tel Aviv Sourasky Medical Center, Sackler School of Medicine, 6 Weizmann Street, 64239 Tel Aviv, Israel
    Parkinsonism Relat Disord 8:243-6. 2002
    ..The correlation between the PDQ-39 and GSL (r=-0.334) improved by adding the QoSL-Q, as a 9th dimension to the PDQ-39 (r=-0.405). The QoSL-Q is a reliable tool assessed a unique and important dimension not evaluated by the PDQ-39...
  84. ncbi request reprint Unverricht-Lundborg disease in a five-generation Arab family: instability of dodecamer repeats
    A Mazarib
    Department of Neurology, Tel Aviv Sourasky Medical Center, Israel
    Neurology 57:1050-4. 2001
    ..ULD is caused by mutations in the cystatin B (CSTB) gene; the most common mutation is expansion of a dodecamer repeat near the promoter. The authors studied a five-generation Arab family with ULD lacking photosensitivity...
  85. ncbi request reprint Stroke in hospitalized patients: are there special risk factors?
    L Nadav
    Internal Medicine Department H, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    Cerebrovasc Dis 13:127-31. 2002
    ..The aim of our study was to evaluate the potential risk factors associated with stroke, which occurred in patients hospitalized for other illnesses...
  86. ncbi request reprint High b-value q-space analyzed diffusion-weighted MRI: application to multiple sclerosis
    Y Assaf
    School of Chemistry, Raymond and Beverly Sackler Faculty of Exact Sciences, Tel Aviv University, Ramat Aviv, Tel Aviv, Israel
    Magn Reson Med 47:115-26. 2002
    ....
  87. ncbi request reprint APOE genotype is a major predictor of long-term progression of disability in MS
    J Chapman
    Department of Neurology, Sackler Faculty of Medicine, Tel Aviv Medical Center, Israel
    Neurology 56:312-6. 2001
    ..In this study, these findings are substantiated and extended in a much larger group of patients followed for up to 40 years...
  88. doi request reprint Visual evoked potentials in idiopathic intracranial hypertension
    Anat Kesler
    Department of Ophthalmology, Neuro Ophthalmology Unit, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
    Clin Neurol Neurosurg 111:433-6. 2009
    ..Since visual loss is a serious complication of idiopathic intracranial hypertension (IIH), we measured VEP in an attempt to evaluate quantitatively the optic nerve damage in patients with chronic IIH...
  89. doi request reprint Phosphatidylserine containing omega-3 fatty acids may improve memory abilities in non-demented elderly with memory complaints: a double-blind placebo-controlled trial
    Veronika Vakhapova
    Neurology Department, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
    Dement Geriatr Cogn Disord 29:467-74. 2010
    ..We evaluated the efficacy of a novel preparation of PS containing omega-3 long-chain polyunsaturated fatty acids attached to its backbone (PS-DHA) in non-demented elderly with memory complaints...
  90. ncbi request reprint Changes in axonal morphology in experimental autoimmune neuritis as studied by high b-value q-space (1)H and (2)H DQF diffusion magnetic resonance spectroscopy
    Yaniv Assaf
    School of Chemistry, The Raymond and Beverly Sackler Faculty of Exact Sciences, Tel Aviv University, Ramat Aviv, Tel Aviv, Israel
    Magn Reson Med 48:71-81. 2002
    ..This study demonstrates the utility of high-b-value q-space diffusion MRS for studying white matter-associated disorders in general...
  91. ncbi request reprint Oral solution of levodopa ethylester for treatment of response fluctuations in patients with advanced Parkinson's disease
    Ruth Djaldetti
    Department of Neurology, Rabin Medical Center, Petah Tiqva, Israel
    Mov Disord 17:297-302. 2002
    ..Results indicate that LDEE solution is beneficial in ameliorating delayed on and no-on response fluctuations. This effect of LDEE is due to more rapid levodopa absorption...
  92. ncbi request reprint Identification of histidine-rich glycoprotein, a potential autoantigen, in human and rat brain preparations
    Catrin Ball-Rosen
    Department of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel Aviv University, Ramat Aviv 69978, Israel
    Ann N Y Acad Sci 1109:473-83. 2007
    ..IgG from most APS patients bound to HRGP, which shares distinct biochemical properties with beta2-GPI, is present in the brain and may be an important autoantigen...
  93. ncbi request reprint Increased thrombin inhibition in experimental autoimmune encephalomyelitis
    Orit Beilin
    Department of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    J Neurosci Res 79:351-9. 2005
    ..005). Increased brain thrombin inhibition at the clinical peak of EAE probably reflects increased influx of plasma thrombin inhibitors. Early PN-1 changes represent a potential target for thrombin modulating drugs in EAE and MS...
  94. ncbi request reprint Inhibition of Ras attenuates the course of experimental autoimmune neuritis
    Michal Kafri
    Department of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel Aviv University, Israel
    J Neuroimmunol 168:46-55. 2005
    ..Effects were confirmed by rotarod and nerve conduction studies. An inactive analogue, geranylthiosalicylate, had no clinical effect. Inhibition of Ras is of potential use in the treatment of inflammatory neuropathies...
  95. ncbi request reprint Sexual dysfunction in Parkinson's disease
    Gila Bronner
    Movement Disorders Unit, Department of Neurology, Tel Aviv Souraski Medical Center, Tel Aviv, Israel
    J Sex Marital Ther 30:95-105. 2004
    ..3% men and 21.9% women). Associated illnesses, use of medications, and advanced stage of PD contributed to sexual dysfunction...
  96. ncbi request reprint Development of dyskinesias in a 5-year trial of ropinirole and L-dopa
    Olivier Rascol
    Clinical Investigation Centre, Department of Pharmacology and INSERM U455, Toulouse Hospital, Toulouse, France
    Mov Disord 21:1844-50. 2006
    ..Early use of ropinirole postpones the onset of dyskinesias, but these benefits decline when levodopa therapy is started, with no evidence of a subsequent rapid "catch-up" or a persisting preventive effect...
  97. ncbi request reprint [Depression precedes development of dementia]
    Ilan Halperin
    Tel Aviv Sourasky Medical Center, Neurology Department, Memory Clinic
    Harefuah 147:335-9, 373. 2008
    ....
  98. ncbi request reprint Transdermal therapy in Parkinson's disease
    Amos D Korczyn
    Lancet Neurol 6:475-6. 2007
  99. ncbi request reprint [The real and ideal in the evaluation of functional competence among demented patients]
    Alon Ariel
    Harefuah 141:795-8, 858. 2002
    ..The limits of available methods are discussed with practical suggestions for the development of such a test...
  100. ncbi request reprint Homocysteine, stroke, and dementia
    Amos D Korczyn
    Stroke 33:2343-4. 2002
  101. ncbi request reprint [Mild cognitive impairment (MCI): characteristics, risk factors and prevention]
    Ilan Halperin
    Sourasky Medical Center, Department of Neurololgy, Memory Clinic, Tel Aviv University
    Harefuah 145:229-34, 243. 2006
    ..Despite the controversies regarding the diagnosis of MCI and its exact definition, great progress has been achieved in identifying brain changes, genetic risk factors and prevention factors associated with MCI...