D Joel

Summary

Affiliation: Tel Aviv University
Country: Israel

Publications

  1. ncbi The role of 5-HT2A and 5-HT2C receptors in the signal attenuation rat model of obsessive-compulsive disorder
    Shlomit Flaisher-Grinberg
    Department of Psychology, Tel Aviv University, Ramat Aviv, Tel Aviv, Israel
    Int J Neuropsychopharmacol 11:811-25. 2008
  2. ncbi The role of the striatum in compulsive behavior in intact and orbitofrontal-cortex-lesioned rats: possible involvement of the serotonergic system
    Eduardo A Schilman
    Department of Psychology, Tel Aviv University, Tel Aviv, Israel
    Neuropsychopharmacology 35:1026-39. 2010
  3. ncbi Fimbria-fornix cut affects spontaneous activity, two-way avoidance and delayed non matching to sample, but not latent inhibition
    I Weiner
    Department of Psychology, Tel Aviv University, Ramat Aviv, Israel
    Behav Brain Res 96:59-70. 1998
  4. ncbi Role of the orbital cortex and of the serotonergic system in a rat model of obsessive compulsive disorder
    D Joel
    Department of Psychology, Tel Aviv University, Ramat Aviv, Tel Aviv 69978, Israel
    Neuroscience 130:25-36. 2005
  5. ncbi Reinforcement learning signals in the human striatum distinguish learners from nonlearners during reward-based decision making
    Tom Schonberg
    Department of Psychology, Tel Aviv University, Tel Aviv 69978, Israel
    J Neurosci 27:12860-7. 2007
  6. ncbi 'Compulsive' lever-pressing in rats is attenuated by the serotonin re-uptake inhibitors paroxetine and fluvoxamine but not by the tricyclic antidepressant desipramine or the anxiolytic diazepam
    D Joel
    Department of Psychology, Tel Aviv University, Tel Aviv, Israel
    Behav Pharmacol 15:241-52. 2004
  7. ncbi 'Compulsive' lever pressing in rats is enhanced following lesions to the orbital cortex, but not to the basolateral nucleus of the amygdala or to the dorsal medial prefrontal cortex
    Daphna Joel
    Department of Psychology, Tel Aviv University, Ramat Aviv, Tel Aviv 69978, Israel
    Eur J Neurosci 21:2252-62. 2005
  8. ncbi Deficits induced by quinolinic acid lesion to the striatum in a position discrimination and reversal task are ameliorated by permanent and temporary lesion to the globus pallidus: a potential novel treatment in a rat model of Huntington's disease
    Daphna Joel
    Department of Psychology, Tel Aviv University, Tel Aviv, Israel
    Mov Disord 18:1499-507. 2003
  9. ncbi Current animal models of obsessive compulsive disorder: a critical review
    Daphna Joel
    Department of Psychology, Tel Aviv University, Ramat Aviv, Tel Aviv 69978, Israel
    Prog Neuropsychopharmacol Biol Psychiatry 30:374-88. 2006
  10. ncbi Selective alleviation of compulsive lever-pressing in rats by D1, but not D2, blockade: possible implications for the involvement of D1 receptors in obsessive-compulsive disorder
    Daphna Joel
    Department of Psychology, Tel Aviv University, Romat Aviv, Israel
    Neuropsychopharmacology 28:77-85. 2003

Collaborators

Detail Information

Publications32

  1. ncbi The role of 5-HT2A and 5-HT2C receptors in the signal attenuation rat model of obsessive-compulsive disorder
    Shlomit Flaisher-Grinberg
    Department of Psychology, Tel Aviv University, Ramat Aviv, Tel Aviv, Israel
    Int J Neuropsychopharmacol 11:811-25. 2008
    ..The results of these experiments suggest that blockade of 5-HT2Creceptors may have an anti-compulsive effect in OCD patients, and that this effect may be mediated by5-HT2C receptors within the orbitofrontal cortex...
  2. ncbi The role of the striatum in compulsive behavior in intact and orbitofrontal-cortex-lesioned rats: possible involvement of the serotonergic system
    Eduardo A Schilman
    Department of Psychology, Tel Aviv University, Tel Aviv, Israel
    Neuropsychopharmacology 35:1026-39. 2010
    ....
  3. ncbi Fimbria-fornix cut affects spontaneous activity, two-way avoidance and delayed non matching to sample, but not latent inhibition
    I Weiner
    Department of Psychology, Tel Aviv University, Ramat Aviv, Israel
    Behav Brain Res 96:59-70. 1998
    ..The implications of these results for the neural circuitry of LI are discussed...
  4. ncbi Role of the orbital cortex and of the serotonergic system in a rat model of obsessive compulsive disorder
    D Joel
    Department of Psychology, Tel Aviv University, Ramat Aviv, Tel Aviv 69978, Israel
    Neuroscience 130:25-36. 2005
    ....
  5. ncbi Reinforcement learning signals in the human striatum distinguish learners from nonlearners during reward-based decision making
    Tom Schonberg
    Department of Psychology, Tel Aviv University, Tel Aviv 69978, Israel
    J Neurosci 27:12860-7. 2007
    ..Thus, spontaneously observed individual differences in decision making performance demonstrate the suggested dependence of this type of learning on the functional integrity of the dopaminergic striatal system in humans...
  6. ncbi 'Compulsive' lever-pressing in rats is attenuated by the serotonin re-uptake inhibitors paroxetine and fluvoxamine but not by the tricyclic antidepressant desipramine or the anxiolytic diazepam
    D Joel
    Department of Psychology, Tel Aviv University, Tel Aviv, Israel
    Behav Pharmacol 15:241-52. 2004
    ..The present findings strengthen the suggestion that compulsive lever-pressing may serve to model compulsive behavior in OCD, and lends the model predictive validity...
  7. ncbi 'Compulsive' lever pressing in rats is enhanced following lesions to the orbital cortex, but not to the basolateral nucleus of the amygdala or to the dorsal medial prefrontal cortex
    Daphna Joel
    Department of Psychology, Tel Aviv University, Ramat Aviv, Tel Aviv 69978, Israel
    Eur J Neurosci 21:2252-62. 2005
    ....
  8. ncbi Deficits induced by quinolinic acid lesion to the striatum in a position discrimination and reversal task are ameliorated by permanent and temporary lesion to the globus pallidus: a potential novel treatment in a rat model of Huntington's disease
    Daphna Joel
    Department of Psychology, Tel Aviv University, Tel Aviv, Israel
    Mov Disord 18:1499-507. 2003
    ....
  9. ncbi Current animal models of obsessive compulsive disorder: a critical review
    Daphna Joel
    Department of Psychology, Tel Aviv University, Ramat Aviv, Tel Aviv 69978, Israel
    Prog Neuropsychopharmacol Biol Psychiatry 30:374-88. 2006
    ....
  10. ncbi Selective alleviation of compulsive lever-pressing in rats by D1, but not D2, blockade: possible implications for the involvement of D1 receptors in obsessive-compulsive disorder
    Daphna Joel
    Department of Psychology, Tel Aviv University, Romat Aviv, Israel
    Neuropsychopharmacology 28:77-85. 2003
    ..The implications of these results for the pathophysiology and treatment of obsessive-compulsive disorder are discussed...
  11. ncbi Actor-critic models of the basal ganglia: new anatomical and computational perspectives
    Daphna Joel
    Department of Psychology, Tel Aviv University, Ramat Aviv, Israel
    Neural Netw 15:535-47. 2002
    ..We conclude with a short discussion of the dual role of the dopamine signal in RL and in behavioral switching...
  12. ncbi Enhancement of excessive lever-pressing after post-training signal attenuation in rats by repeated administration of the D1 antagonist SCH 23390 or the D2 agonist quinpirole, but not the D1 agonist SKF 38393 or the D2 antagonist haloperidol
    D Joel
    Department of Psychology, Tel Aviv University, Israel
    Behav Neurosci 115:1291-300. 2001
    ..These results may link the hypothesis that obsessions and compulsions result from a deficient response feedback mechanism with findings implicating dopaminergic abnormalities in the production of obsessions and compulsions...
  13. ncbi Open interconnected model of basal ganglia-thalamocortical circuitry and its relevance to the clinical syndrome of Huntington's disease
    D Joel
    Department of Psychology, Tel Aviv University, Ramat Aviv, Tel Aviv 69978, Israel
    Mov Disord 16:407-23. 2001
    ..Finally, we suggest a potential novel treatment of HD and provide supportive evidence from a rat model of the disease...
  14. ncbi Excessive lever pressing following post-training signal attenuation in rats: a possible animal model of obsessive compulsive disorder?
    D Joel
    Department of Psychology, Tel Aviv University, Ramat Aviv, Tel Aviv 69978, Israel
    Behav Brain Res 123:77-87. 2001
    ..Based on these results we propose that post-training signal attenuation may provide a rat model of obsessive compulsive disorder...
  15. ncbi The connections of the dopaminergic system with the striatum in rats and primates: an analysis with respect to the functional and compartmental organization of the striatum
    D Joel
    Department of Psychology, Tel Aviv University, Ramat Aviv, Tel Aviv, Israel
    Neuroscience 96:451-74. 2000
    ..Finally, we incorporate the striatal connections with the dopaminergic system into an open-interconnected scheme of basal ganglia-thalamocortical circuitry...
  16. ncbi The signal attenuation rat model of obsessive-compulsive disorder: a review
    Daphna Joel
    Department of Psychology, Tel Aviv University, Ramat Aviv, Tel Aviv, 69978, Israel
    Psychopharmacology (Berl) 186:487-503. 2006
    ....
  17. ncbi The effects of temporary inactivation of the orbital cortex in the signal attenuation rat model of obsessive compulsive disorder
    Daphna Joel
    Department of Psychology, Tel Aviv University, Tel Aviv, Israel
    Behav Neurosci 120:976-83. 2006
    ....
  18. ncbi Impaired procedural learning in obsessive-compulsive disorder and Parkinson's disease, but not in major depressive disorder
    Daphna Joel
    Department of Psychology, Tel Aviv University, Ramat Aviv, Tel Aviv 69978, Israel
    Behav Brain Res 157:253-63. 2005
    ..Two different interpretations are suggested: that the striatal system is dysfunctional in OCD, or that inappropriate explicit processing in OCD interferes with the functioning of the striatal system...
  19. ncbi Amelioration of behavioral deficits in a rat model of Huntington's disease by an excitotoxic lesion to the globus pallidus
    Liat Ayalon
    Department of Psychology, Tel-Aviv University, Ramat-Aviv, Tel Aviv 69978, Israel
    Exp Neurol 186:46-58. 2004
    ....
  20. ncbi The connections of the primate subthalamic nucleus: indirect pathways and the open-interconnected scheme of basal ganglia-thalamocortical circuitry
    D Joel
    Department of Psychology, Tel Aviv University, Ramat Aviv, Tel Aviv, Israel
    Brain Res Brain Res Rev 23:62-78. 1997
    ..The clinical implications of this scheme for Huntington's disease are discussed...
  21. ncbi The effects of electrolytic lesion to the shell subterritory of the nucleus accumbens on delayed non-matching-to-sample and four-arm baited eight-arm radial-maze tasks
    G Gal
    Department of Psychology, Tel Aviv University, Israel
    Behav Neurosci 111:92-103. 1997
    ..The results suggest that the inappropriate use of response strategy by shell animals was a result of their inability to switch from initial response strategy to a later, more appropriate, memory-dependent strategy...
  22. ncbi Strain differences in 'compulsive' lever-pressing
    Lior Brimberg
    Department of Psychology, Tel Aviv University, Ramat Aviv, Tel Aviv 69978, Israel
    Behav Brain Res 179:141-51. 2007
    ..The possibility that these strain differences are related to strain differences in the serotonergic and dopaminergic systems are discussed in light of current knowledge of the pathophysiology and pharmacotherapy of OCD...
  23. ncbi A comparison of drug effects in latent inhibition and the forced swim test differentiates between the typical antipsychotic haloperidol, the atypical antipsychotics clozapine and olanzapine, and the antidepressants imipramine and paroxetine
    I Weiner
    Department of Psychology, Tel Aviv University, Tel Aviv, Israel
    Behav Pharmacol 14:215-22. 2003
    ..Thus, the comparison of drug effects in LI and FST enabled a discrimination between typical and atypical APDs without losing selectivity for APDs...
  24. ncbi High frequency stimulation and pharmacological inactivation of the subthalamic nucleus reduces 'compulsive' lever-pressing in rats
    Oded Klavir
    Department of Psychology, Tel Aviv University, Ramat Aviv, Tel Aviv 69978, Israel
    Exp Neurol 215:101-9. 2009
    ..These findings support the possibility that HFS of the STN may provide an additional therapeutic strategy for OCD...
  25. ncbi Selective impairment of prediction error signaling in human dorsolateral but not ventral striatum in Parkinson's disease patients: evidence from a model-based fMRI study
    Tom Schonberg
    Department of Psychology, Tel Aviv University Tel Aviv, Israel
    Neuroimage 49:772-81. 2010
    ..These results also provide evidence for a deficiency in PE signaling in the dorsolateral striatum of PD patients that may offer an explanation for their deficits observed in other reward learning tasks...
  26. ncbi Long-term functional consequences of quinolinic acid striatal lesions and their alteration following an addition of a globus pallidus lesion assessed using pharmacological magnetic resonance imaging
    Ricardo Tarrasch
    Psychology Department, Tel Aviv University, Tel Aviv, Israel
    Exp Neurol 196:244-53. 2005
    ..These results are further discussed in view of our previous demonstration that lesions to the GP can reverse several behavioral deficits produced by a striatal lesion...
  27. ncbi The role of NMDA receptors in the signal attenuation rat model of obsessive-compulsive disorder
    Noa Albelda
    Department of Psychology, Tel Aviv University, Tel Aviv, Israel
    Psychopharmacology (Berl) 210:13-24. 2010
    ....
  28. ncbi High frequency stimulation and temporary inactivation of the subthalamic nucleus reduce quinpirole-induced compulsive checking behavior in rats
    Christine Winter
    Department of Psychiatry and Psychotherapy, Charite Campus Mitte, Germany Department of Neurology, Charite Campus Mitte, Germany
    Exp Neurol 210:217-28. 2008
    ..We conclude that functional inhibition of the STN can alleviate compulsive checking, and suggest the STN as a potential target structure for HFS in the treatment of OCD...
  29. ncbi The orbital cortex in rats topographically projects to central parts of the caudate-putamen complex
    Eduardo A Schilman
    Department of Anatomy and Neurosciences, Institute for Clinical and Experimental Neurosciences, Graduate School Neuroscience Amsterdam, VU University Medical Center, Amsterdam, The Netherlands
    Neurosci Lett 432:40-5. 2008
    ..In contrast to nonhuman primates, the remainder of the rat nucleus accumbens is virtually free of orbital projections...
  30. ncbi The role of the subthalamic nucleus in 'compulsive' behavior in rats
    Christine Winter
    Department of Psychiatry and Psychotherapy, Charite Campus Mitte, University Medicine, Berlin, Germany
    Eur J Neurosci 27:1902-11. 2008
    ....
  31. ncbi Tonic dopamine: opportunity costs and the control of response vigor
    Yael Niv
    Interdisciplinary Center for Neural Computation, The Hebrew University of Jerusalem, Jerusalem, 91904, Israel
    Psychopharmacology (Berl) 191:507-20. 2007
    ....
  32. ncbi A normative perspective on motivation
    Yael Niv
    Interdisciplinary Center for Neural Computation, Hebrew University, Jerusalem, Israel
    Trends Cogn Sci 10:375-81. 2006
    ..However, in novel states, we propose that outcome-independent, global effects of the utilities can 'energize' habitual actions...