Edith Hochhauser

Summary

Affiliation: Tel Aviv University
Country: Israel

Publications

  1. ncbi request reprint Recombinant human erythropoietin attenuates hepatic injury induced by ischemia/reperfusion in an isolated mouse liver model
    Edith Hochhauser
    Cardiac Research Laboratory of Department of Cardiothoracic Surgery, Rabin Medical Center, Beilinson Campus, Petah Tiqva and Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
    Apoptosis 13:77-86. 2008
  2. ncbi request reprint Bax ablation protects against myocardial ischemia-reperfusion injury in transgenic mice
    Edith Hochhauser
    Cardiac Research Laboratory, Department of Cardiothoracic Surgery, Tel Aviv University, Israel
    Am J Physiol Heart Circ Physiol 284:H2351-9. 2003
  3. ncbi request reprint Role of adenosine receptor activation in antioxidant enzyme regulation during ischemia-reperfusion in the isolated rat heart
    Edith Hochhauser
    The Cardiac Research Laboratory of the Department of Cardiothoracic Surgery, Felsenstein Medical Research Center, Sackler Faculty of Medicine, Tel Aviv University, Rabin Medical Center, Petah Tikva, Israel
    Antioxid Redox Signal 6:335-44. 2004
  4. ncbi request reprint The protective effect of prior ischemia reperfusion adenosine A1 or A3 receptor activation in the normal and hypertrophied heart
    Edith Hochhauser
    Department of Cardiothoracic Surgery, The Cardiac Research Laboratory, Felsenstein Medical Research Center, Rabin Medical Center, Petach Tikva 49100, Tel Aviv University, Israel
    Interact Cardiovasc Thorac Surg 6:363-8. 2007
  5. ncbi request reprint Bax deficiency reduces infarct size and improves long-term function after myocardial infarction
    E Hochhauser
    Department of Cardiothoracic Surgery, Felsenstein Medical Research Center, Rabin Medical Center, Petah Tikva, Israel
    Cell Biochem Biophys 47:11-20. 2007
  6. doi request reprint Dual effect of erythropoietin on liver protection and regeneration after subtotal hepatectomy in rats
    Franklin Greif
    Department of Surgery A, Rabin Medical Center, Beilinson Hospital, Petah Tiqwa, Israel
    Liver Transpl 16:631-8. 2010
  7. pmc Exercise training improves cardiac function and attenuates arrhythmia in CPVT mice
    Efrat Kurtzwald-Josefson
    Leviev Heart Center, Sheba Medical Center, Tel Hashomer, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
    J Appl Physiol (1985) 113:1677-83. 2012
  8. doi request reprint Erythropoietin increases survival and attenuates fulminant hepatic failure injury induced by D-galactosamine/lipopolysaccharide in mice
    Ziv Ben-Ari
    Liver Institute, Rabin Medical Center, Beilinson Hospital, Petah Tikva, Israel
    Transplantation 92:18-24. 2011
  9. ncbi request reprint Bax ablation protects against hepatic ischemia/reperfusion injury in transgenic mice
    Ziv Ben-Ari
    Liver Institute and Department of Medicine D, Tel Aviv University, Tel Aviv, Israel
    Liver Transpl 13:1181-8. 2007
  10. doi request reprint Elevated level of pro-inflammatory eicosanoids and EPC dysfunction in diabetic patients with cardiac ischemia
    Yossi Issan
    Cardiac Research Laboratory at the Felsenstein Medical Research Institute, Rabin Medical Center, Petah Tikva and the Sackler Faculty of Medicine, Tel Aviv University, Israel
    Prostaglandins Other Lipid Mediat 100:15-21. 2013

Collaborators

Detail Information

Publications30

  1. ncbi request reprint Recombinant human erythropoietin attenuates hepatic injury induced by ischemia/reperfusion in an isolated mouse liver model
    Edith Hochhauser
    Cardiac Research Laboratory of Department of Cardiothoracic Surgery, Rabin Medical Center, Beilinson Campus, Petah Tiqva and Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
    Apoptosis 13:77-86. 2008
    ..The aim of the study was to investigate the effect of different regimens of rhEPO in preventing apoptosis following I/R-induced hepatic injury...
  2. ncbi request reprint Bax ablation protects against myocardial ischemia-reperfusion injury in transgenic mice
    Edith Hochhauser
    Cardiac Research Laboratory, Department of Cardiothoracic Surgery, Tel Aviv University, Israel
    Am J Physiol Heart Circ Physiol 284:H2351-9. 2003
    ..The superior tolerance of Bax knockout hearts to I/R injury recommends this gene as a potential target for therapeutic intervention in patients with severe and intractable myocardial ischemia...
  3. ncbi request reprint Role of adenosine receptor activation in antioxidant enzyme regulation during ischemia-reperfusion in the isolated rat heart
    Edith Hochhauser
    The Cardiac Research Laboratory of the Department of Cardiothoracic Surgery, Felsenstein Medical Research Center, Sackler Faculty of Medicine, Tel Aviv University, Rabin Medical Center, Petah Tikva, Israel
    Antioxid Redox Signal 6:335-44. 2004
    ..This protection was partially related to the higher myocardial activity of superoxide dismutase and catalase...
  4. ncbi request reprint The protective effect of prior ischemia reperfusion adenosine A1 or A3 receptor activation in the normal and hypertrophied heart
    Edith Hochhauser
    Department of Cardiothoracic Surgery, The Cardiac Research Laboratory, Felsenstein Medical Research Center, Rabin Medical Center, Petach Tikva 49100, Tel Aviv University, Israel
    Interact Cardiovasc Thorac Surg 6:363-8. 2007
    ..In addition, we examined the p38 MAPK activation in this process...
  5. ncbi request reprint Bax deficiency reduces infarct size and improves long-term function after myocardial infarction
    E Hochhauser
    Department of Cardiothoracic Surgery, Felsenstein Medical Research Center, Rabin Medical Center, Petah Tikva, Israel
    Cell Biochem Biophys 47:11-20. 2007
    ..The Bax gene appears to play a significant role in the post-MI response that should be further investigated...
  6. doi request reprint Dual effect of erythropoietin on liver protection and regeneration after subtotal hepatectomy in rats
    Franklin Greif
    Department of Surgery A, Rabin Medical Center, Beilinson Hospital, Petah Tiqwa, Israel
    Liver Transpl 16:631-8. 2010
    ..05) in comparison with the control group. In conclusion, rhEPO treatment may offer a unique beneficial dual-function strategy for hepatic protection and regeneration immediately after subtotal hepatectomy in rats...
  7. pmc Exercise training improves cardiac function and attenuates arrhythmia in CPVT mice
    Efrat Kurtzwald-Josefson
    Leviev Heart Center, Sheba Medical Center, Tel Hashomer, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
    J Appl Physiol (1985) 113:1677-83. 2012
    ..We conclude that, in KO mice, which recapitulate the phenotype of human CPVT2, exercise training is well tolerated and could offer a strategy for heart conditioning against stress-induced arrhythmia...
  8. doi request reprint Erythropoietin increases survival and attenuates fulminant hepatic failure injury induced by D-galactosamine/lipopolysaccharide in mice
    Ziv Ben-Ari
    Liver Institute, Rabin Medical Center, Beilinson Hospital, Petah Tikva, Israel
    Transplantation 92:18-24. 2011
    ..Erythropoietin has a powerful tissue-protective effect in animal models. The aim of this study was to investigate the effect and mechanism of recombinant human erythropoietin (rhEPO) administration in FHF mice...
  9. ncbi request reprint Bax ablation protects against hepatic ischemia/reperfusion injury in transgenic mice
    Ziv Ben-Ari
    Liver Institute and Department of Medicine D, Tel Aviv University, Tel Aviv, Israel
    Liver Transpl 13:1181-8. 2007
    ..In conclusion, The better tolerance of Bax knockout livers to I/R injury suggests that the Bax gene may serve as a potential target for therapeutic intervention in hepatic I/R injury...
  10. doi request reprint Elevated level of pro-inflammatory eicosanoids and EPC dysfunction in diabetic patients with cardiac ischemia
    Yossi Issan
    Cardiac Research Laboratory at the Felsenstein Medical Research Institute, Rabin Medical Center, Petah Tikva and the Sackler Faculty of Medicine, Tel Aviv University, Israel
    Prostaglandins Other Lipid Mediat 100:15-21. 2013
    ....
  11. doi request reprint The role of excessive versus acute administration of erythropoietin in attenuating hepatic ischemia-reperfusion injury
    Orit Pappo
    Department of Histopathology, Rabin Medical Center, Beilinson Hospital, Petah Tiqva, Israel
    Can J Physiol Pharmacol 88:1130-7. 2010
    ..However, in excessive EPO overexpression, the initial liver injury abolished the beneficial effect of EPO. These findings have important implications for the potential use of acute EPO in I/R injury during liver transplantation...
  12. ncbi request reprint The role of mutant protein level in autosomal recessive catecholamine dependent polymorphic ventricular tachycardia (CPVT2)
    Guy Katz
    Leviev Heart Center, Sheba Medical Center, Tel Hashomer and Sackler School of, Medicine, Tel Aviv University, Tel Aviv, Israel
    Biochem Pharmacol 86:1576-83. 2013
    ..Its expression decreases with age and is inversely related to arrhythmia severity. Preventing the degradation of mutant protein should be explored as a possible therapeutic strategy in appropriate CPVT2 patients...
  13. doi request reprint Reduced hepatic injury in Toll-like receptor 4-deficient mice following D-galactosamine/lipopolysaccharide-induced fulminant hepatic failure
    Ziv Ben Ari
    Liver Institute, Beilinson Hospital Rabin Medical Center, Petah Tiqwa, Israel
    Cell Physiol Biochem 29:41-50. 2012
    ..Down-regulation of TLR4 expression plays a pivotal role in GalN/LPS induced FHF. These findings might have important implications for the use of the anti TLR4 protein signaling as a potential target for therapeutic intervention in FHF...
  14. doi request reprint Increased glycogen stores due to gamma-AMPK overexpression protects against ischemia and reperfusion damage
    Michal Ofir
    The Cardiac Research Laboratory, Felsenstein Medical Research Center, Rabin Medical Center, Tel Aviv University, Petah Tikva 49100, Israel
    Biochem Pharmacol 75:1482-91. 2008
    ..These findings demonstrate the potential of heart protection from ischemia and reperfusion injury through metabolic manipulation increasing the level and utilization of myocardial glycogen...
  15. doi request reprint Uridine-5'-triphosphate protects against hepatic- ischemic/reperfusion injury in mice
    Ziv Ben-Ari
    Liver Institute, Rabin Medical Center, Beilinson Hospital, Petah Tiqwa, Israel
    Transplantation 87:1155-62. 2009
    ..ATP and UTP binds to cell membranes of the hepatocytes through P2Y receptors. Our aim was to investigate the role of UTP on the hepatic injury induced by ischemia...
  16. pmc Heme oxygenase-1 induction improves cardiac function following myocardial ischemia by reducing oxidative stress
    Yossi Issan
    Cardiac Research Laboratory, Felsenstein Medical Research Institute, Tel Aviv University, Petah Tikva, Israel
    PLoS ONE 9:e92246. 2014
    ..We aimed to investigate the protection and the mechanisms of HO-1 induction in cardiomyocytes subjected to hypoxia and in diabetic mice subjected to LAD ligation...
  17. pmc Rosiglitazone and bezafibrate modulate gene expression in a rat model of non-alcoholic fatty liver disease--a historical prospective
    Hemda Schmilovitz-Weiss
    Division of Gastroenterology, Rabin Medical Center, Hasharon Hospital, Petach Tikva, Israel
    Lipids Health Dis 12:41. 2013
    ..Our aim was to characterize three genes involved in a rat model of non-alcoholic fatty liver disease and investigate the effect of rosiglitazone and bezafibrate...
  18. ncbi request reprint Optimizing catecholaminergic polymorphic ventricular tachycardia therapy in calsequestrin-mutant mice
    Guy Katz
    Heart Institute, Sheba Medical Center, Tel Hashomer and Sackler School of Medicine, Tel Aviv University, Israel
    Heart Rhythm 7:1676-82. 2010
    ..Beta-adrenergic blockers are the therapy of choice but fail to control arrhythmia in up to 50% of patients...
  19. pmc Bone marrow and nonbone marrow Toll like receptor 4 regulate acute hepatic injury induced by endotoxemia
    Edith Hochhauser
    Felsenstein Medical Research Center, Rabin Medical Center, Petach Tikva, Israel
    PLoS ONE 8:e73041. 2013
    ..We examined whether hepatic Toll-like receptor 4 (TLR4) is involved in the acute hepatic injury caused by the administration of lipopolysaccharide (LPS) (septic shock model)...
  20. ncbi request reprint Role of anti-tumor necrosis factor-alpha in ischemia/reperfusion injury in isolated rat liver in a blood-free environment
    Ziv Ben-Ari
    Liver Institute and Department of Medicine D, Rabin Medical Center, Beilinson Campus, Petah Tiqva, Israel
    Transplantation 73:1875-80. 2002
    ..Specifically, its effect on liver cell apoptosis through the modulation of caspase activity was examined in a blood-free environment...
  21. pmc Popeye domain containing 1 (Popdc1/Bves) is a caveolae-associated protein involved in ischemia tolerance
    Yifat Alcalay
    The Felsenstein Medical Research Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    PLoS ONE 8:e71100. 2013
    ..The results indicate that Popdc1 is a caveolae-associated protein important for the preservation of caveolae structural and functional integrity and for heart protection. ..
  22. ncbi request reprint [AMP-activated protein kinase: how a mistake in energy gauge causes glycogen storage]
    Michal Ofir
    The Cardiac Research Laboratory, Felsenstein Medical Research Center, Rabin Medical Center, Petah Tikva
    Harefuah 146:770-5, 813-4. 2007
    ..Will AMPK ever emerge as a therapeutic target? Bench experiments suggest its potential in treating diabetes, ischemia and cell cycle regulation but much work is needed until these developments reach the bedside...
  23. pmc P2Y2 receptor agonist with enhanced stability protects the heart from ischemic damage in vitro and in vivo
    Edith Hochhauser
    Cardiac Research Laboratory of the Department of Cardiothoracic Surgery, Felsenstein Medical Research Center, Rabin Medical Center, Tel Aviv University, Petach Tikva, Israel
    Purinergic Signal 9:633-42. 2013
    ..05) and c-Jun phosphorylation increased. Thus, P2Y2R activation protects cardiomyocytes from hypoxia in vitro and reduces post-ischemic myocardial damage in vivo. ..
  24. doi request reprint Endothelial progenitor cell function inversely correlates with long-term glucose control in diabetic patients: association with the attenuation of the heme oxygenase-adiponectin axis
    Yossi Issan
    Cardiac Research Laboratory, The Felsenstein Medical Research Center, Tel Aviv University, Tel Aviv, Israel
    Can J Cardiol 28:728-36. 2012
    ....
  25. doi request reprint Protective effect of Bax ablation against cell loss in the retinal ganglion layer induced by optic nerve crush in transgenic mice
    Nitza Goldenberg-Cohen
    Department of Ophthalmology, Schneider Children s Medical Center of Israel, Petah Tiqwa, Israel
    J Neuroophthalmol 31:331-8. 2011
    ..This study sought to elucidate the role of the mitochondrial apoptotic pathway in RGCs using a Bax transgenic knockout mouse model...
  26. doi request reprint Vasoreactivity and histology of the radial artery: comparison of open versus endoscopic approaches
    Benjamin Medalion
    Department of Cardiac Surgery, Rabin Medical Center, Beilinson Campus, Israel
    Eur J Cardiothorac Surg 34:845-9. 2008
    ..To assess this hypothesis, radial artery segments harvested endoscopically or conventionally were studied for reactivity and integrity...
  27. ncbi request reprint TPEN attenuates hepatic apoptotic ischemia/ reperfusion injury and remote early cardiac dysfunction
    E Hochhauser
    The Cardiac Research Laboratory of the Department of Cardiothoracic Surgery, Felsenstein Medical Research Center, Tel Aviv, Israel
    Apoptosis 10:53-62. 2005
    ..In conclusion, TPEN attenuates post-ischemic apoptotic hepatic injury by modulating caspase-3-like activity and reduces the cardioactive substances released from the liver...
  28. ncbi request reprint Effect of adenosine A2A receptor agonist (CGS) on ischemia/reperfusion injury in isolated rat liver
    Z Ben-Ari
    Liver Institute and Department of Medicine D, Rabin Medical Center, Beilinson Campus, Petah Tiqva 49100, Israel
    Apoptosis 10:955-62. 2005
    ..Apoptotic hepatic injury seems to be mediated through caspase-3 activity...
  29. ncbi request reprint Uridine-5'-triphosphate (UTP) reduces infarct size and improves rat heart function after myocardial infarct
    Smadar Yitzhaki
    The Mina and Everard Goodman Faculty of Life Sciences, Bar Ilan University, Ramat Gan 52900, Israel
    Biochem Pharmacol 72:949-55. 2006
    ..The resulting cardioprotection following UTP treatment post ischemia demonstrates a reduction in mitochondrial calcium overload, which can explain the beneficial effect of UTP...
  30. ncbi request reprint Uridine-5'-triphosphate (UTP) maintains cardiac mitochondrial function following chemical and hypoxic stress
    Smadar Yitzhaki
    The Mina and Everard Goodman Faculty of Life Sciences, Bar Ilan University, Ramat Gan, 52900 Israel
    J Mol Cell Cardiol 43:653-62. 2007
    ..We suggest that UTP may act as an uncoupling agent, which exerts a modest mitochondrial depolarization, resulting in a reduction of Ca(2+) uptake, preserving mitochondrial activity, thereby reducing cell damage during hypoxia...