Lazaro Gotloib

Summary

Affiliation: Tel Aviv University
Country: Israel

Publications

  1. ncbi request reprint The mesothelium under the siege of dialysis solutions: old glucose, new glucose, and glucose-free osmotic agents
    Lazaro Gotloib
    Laboratory of Experimental Nephrology, Ha Emek Medical Center, Afula, Israel
    Adv Perit Dial 25:6-10. 2009
  2. ncbi request reprint Use of peritoneal dialysis and mesothelium in non primary renal conditions
    Lazaro Gotloib
    Laboratory of Experimental Nephrology, Ha Emek Medical Center, Afula, Israel
    Adv Perit Dial 25:2-5. 2009
  3. doi request reprint Preservation and modulation of peritoneal function. A potential role of pyruvate and betaine
    Lazaro Gotloib
    Laboratory for Experimental Nephrology, Ha Emek Medical Center, Afula, Israel
    Contrib Nephrol 163:74-81. 2009
  4. doi request reprint Mechanisms of cell death during peritoneal dialysis. A role for osmotic and oxidative stress
    Lazaro Gotloib
    Laboratory of Experimental Nephrology, Ha Emek Medical Center, Afula, Israel
    Contrib Nephrol 163:35-44. 2009
  5. ncbi request reprint The use of peritoneal mesothelium as a potential source of adult stem cells
    L Gotloib
    Laboratory for Experimental Nephrology, Ha Emek Medical Center, Afula 18101, Israel
    Int J Artif Organs 30:501-12. 2007
  6. ncbi request reprint Iron deficiency is a common cause of anemia in chronic kidney disease and can often be corrected with intravenous iron
    Lazaro Gotloib
    Department of Nephrology and Hypertension, Ha Emek Medical Center, Afula, Israel
    J Nephrol 19:161-7. 2006
  7. ncbi request reprint The impact of peritoneal dialysis upon quality of life and mortality of patients with end-stage congestive heart failure
    Lazaro Gotloib
    Department of Nephrology, Ha Emek Medical Center, Afula, Israel
    Contrib Nephrol 150:247-53. 2006
  8. ncbi request reprint Repopulation of the mesothelial monolayer during long-term experimental peritoneal dialysis
    Lazaro Gotloib
    Department of Nephrology, Ha Emek Medical Center, Afula, Israel
    Contrib Nephrol 150:54-61. 2006
  9. ncbi request reprint Peritoneal dialysis in refractory end-stage congestive heart failure: a challenge facing a no-win situation
    Lazaro Gotloib
    Center for Experimental Nephrology, Ha Emek Medical Center, Afula 18101, Israel
    Nephrol Dial Transplant 20:vii32-6. 2005
  10. ncbi request reprint A short review of experimental peritoneal sclerosis: from mice to men
    L Gotloib
    Department of Nephrology, Hypertension and the Research Center for Experimental Nephrology, Ha Emek Medical Center, Afula 18101, Israel
    Int J Artif Organs 28:97-104. 2005

Collaborators

Detail Information

Publications17

  1. ncbi request reprint The mesothelium under the siege of dialysis solutions: old glucose, new glucose, and glucose-free osmotic agents
    Lazaro Gotloib
    Laboratory of Experimental Nephrology, Ha Emek Medical Center, Afula, Israel
    Adv Perit Dial 25:6-10. 2009
    ..Icodextrin does not appear to be more biocompatible than glucose. Amino-acid-based solution is less harmful to the mesothelium, but its usefulness is still limited...
  2. ncbi request reprint Use of peritoneal dialysis and mesothelium in non primary renal conditions
    Lazaro Gotloib
    Laboratory of Experimental Nephrology, Ha Emek Medical Center, Afula, Israel
    Adv Perit Dial 25:2-5. 2009
    ....
  3. doi request reprint Preservation and modulation of peritoneal function. A potential role of pyruvate and betaine
    Lazaro Gotloib
    Laboratory for Experimental Nephrology, Ha Emek Medical Center, Afula, Israel
    Contrib Nephrol 163:74-81. 2009
    ..To review interventions aimed at protecting the peritoneal membrane from the detrimental effects of dialysis solutions, and to analyze proposed pharmacological interventions aiming to modulate peritoneal permeability. Main..
  4. doi request reprint Mechanisms of cell death during peritoneal dialysis. A role for osmotic and oxidative stress
    Lazaro Gotloib
    Laboratory of Experimental Nephrology, Ha Emek Medical Center, Afula, Israel
    Contrib Nephrol 163:35-44. 2009
    ..To offer a condensed description of the modes of cell death and the involved mechanisms behind them as detected in the different layers of the peritoneal tissue during experimental and clinical, long-term peritoneal dialysis (PD)...
  5. ncbi request reprint The use of peritoneal mesothelium as a potential source of adult stem cells
    L Gotloib
    Laboratory for Experimental Nephrology, Ha Emek Medical Center, Afula 18101, Israel
    Int J Artif Organs 30:501-12. 2007
    ..Intensive research is required to define the best environmental conditions to take advantage of this plasticity and make the peritoneal mesothelium an actual option to be applied in regenerative medicine...
  6. ncbi request reprint Iron deficiency is a common cause of anemia in chronic kidney disease and can often be corrected with intravenous iron
    Lazaro Gotloib
    Department of Nephrology and Hypertension, Ha Emek Medical Center, Afula, Israel
    J Nephrol 19:161-7. 2006
    ..The purpose of this work was to study the effects of intravenous (i.v.) iron administration (ferric gluconate - Ferrlecit) on hemoglobin (Hb) of patients with CKD...
  7. ncbi request reprint The impact of peritoneal dialysis upon quality of life and mortality of patients with end-stage congestive heart failure
    Lazaro Gotloib
    Department of Nephrology, Ha Emek Medical Center, Afula, Israel
    Contrib Nephrol 150:247-53. 2006
    ..Use of automated peritoneal dialysis resulted in a significantly improved quality of life and survival...
  8. ncbi request reprint Repopulation of the mesothelial monolayer during long-term experimental peritoneal dialysis
    Lazaro Gotloib
    Department of Nephrology, Ha Emek Medical Center, Afula, Israel
    Contrib Nephrol 150:54-61. 2006
    ..This study describes repopulation of a 'doughnut' like mesothelial ring exfoliated from the anterior liver surface of rats...
  9. ncbi request reprint Peritoneal dialysis in refractory end-stage congestive heart failure: a challenge facing a no-win situation
    Lazaro Gotloib
    Center for Experimental Nephrology, Ha Emek Medical Center, Afula 18101, Israel
    Nephrol Dial Transplant 20:vii32-6. 2005
    ..Peritoneal dialysis applied to CHF patients with or without renal impairment showed clinical functional improvement...
  10. ncbi request reprint A short review of experimental peritoneal sclerosis: from mice to men
    L Gotloib
    Department of Nephrology, Hypertension and the Research Center for Experimental Nephrology, Ha Emek Medical Center, Afula 18101, Israel
    Int J Artif Organs 28:97-104. 2005
    ..It is concluded that peritoneal sclerosis derives mostly from sustained oxidative injury to the peritoneal membrane. Loss of the mesothelial monolayer is the first step in the chain of events leading to this complication...
  11. ncbi request reprint Acute oxidative stress induces peritoneal hyperpermeability, mesothelial loss, and fibrosis
    Lazaro Gotloib
    Department of Nephrology and Hypertension, Ha Emek Medical Center, Afula, Israel
    J Lab Clin Med 143:31-40. 2004
    ....
  12. ncbi request reprint Osmotic agents hamper mesothelial repopulation as seen in the doughnut in vivo model
    Lazaro Gotloib
    Department of Nephrology and Hypertension and the Research Centerfor Experimental Nephrology, Ha Emek Medical Center, Afula, Israel
    Perit Dial Int 25:S26-30. 2005
    ..Conversely, the eventual detrimental effects upon mesothelial cell regeneration have awaked less investigative efforts than those focused on injury...
  13. ncbi request reprint Icodextrin-induced lipid peroxidation disrupts the mesothelial cell cycle engine
    Lazaro Gotloib
    Department of Nephrology and Hypertension and the Research Center for Experimental Nephrology, Ha Emek Medical Center, Afula, Israel
    Free Radic Biol Med 34:419-28. 2003
    ..The 7.5% icodextrin dialysis fluid induces through lipid peroxidation substantial genomic damage, which, in turn, sets the biological mechanisms leading to protective cellular suicide in motion...
  14. ncbi request reprint Mesothelial dysplastic changes and lipid peroxidation induced by 7.5% icodextrin
    Lazaro Gotloib
    Department of Nephrology and Hypertension and the Research Center for Experimental Nephrology, Ha Emek Medical Center, Afula, Israel
    Nephron 92:142-55. 2002
    ..The present investigation exposes the first attempt to investigate the biocompatibility issue in an in vivo and in situ setup...
  15. ncbi request reprint Protective effect of aminoguanidine upon capillary and submesothelial anionic sites
    A Shostak
    Department of Nephrology and Hypertension, Ha'Emek Medical Center, Afula, Israel
    Microvasc Res 61:166-78. 2001
    ..We conclude that the shielding effect of aminoguanidine upon the permselectivity capabilities of the endothelial and mesothelial monolayers appears to be connected, basically to the preservation of anionic fixed charges...
  16. ncbi request reprint Peritoneal transport after long-term exposure to Icodextrin in rats
    Victor Frajewicki
    Institute of Nephrology and Hypertension, Carmel Medical Center, Haifa, Israel
    Nephron 92:174-82. 2002
    ..Icodextrin, an effective osmotic substance that has been proposed as an alternative agent for peritoneal dialysis induces ultrafiltration over long dwells. This study examines the peritoneal transport after exposure to Icodextrin in rats...
  17. ncbi request reprint Agents that modulate peritoneal membrane structure and function
    Jose A Diaz-Buxo
    Home Therapies Development, Fresenius Medical Care North America, Lexington Massachusetts, USA
    Perit Dial Int 27:16-30. 2007
    ..Nonetheless, there is room for further significant improvement in solution biocompatibility and for compounds that may restore peritoneal function...