Research Topics
| Lazaro GotloibSummaryAffiliation: Tel Aviv University Country: Israel Publications
| Collaborators
|
Detail Information
Publications
The mesothelium under the siege of dialysis solutions: old glucose, new glucose, and glucose-free osmotic agentsLazaro Gotloib
Laboratory of Experimental Nephrology, Ha Emek Medical Center, Afula, Israel
Adv Perit Dial 25:6-10. 2009..Icodextrin does not appear to be more biocompatible than glucose. Amino-acid-based solution is less harmful to the mesothelium, but its usefulness is still limited...- Use of peritoneal dialysis and mesothelium in non primary renal conditionsLazaro Gotloib
Laboratory of Experimental Nephrology, Ha Emek Medical Center, Afula, Israel
Adv Perit Dial 25:2-5. 2009.... - Preservation and modulation of peritoneal function. A potential role of pyruvate and betaineLazaro Gotloib
Laboratory for Experimental Nephrology, Ha Emek Medical Center, Afula, Israel
Contrib Nephrol 163:74-81. 2009..Conversely, interventions designed to preserve the peritoneum as a reusable dialyzing living membrane are more promising, especially those aimed at neutralizing oxidative and osmotic injury... - Mechanisms of cell death during peritoneal dialysis. A role for osmotic and oxidative stressLazaro Gotloib
Laboratory of Experimental Nephrology, Ha Emek Medical Center, Afula, Israel
Contrib Nephrol 163:35-44. 2009..Since liberation of oxygen radicals is thereby causally involved in apoptosis, reduced levels of GDPs and/or use of antioxidants appear to be indicated in order to prevent mesothelial, endothelial cells and leukocyte death... - The use of peritoneal mesothelium as a potential source of adult stem cellsL Gotloib
Laboratory for Experimental Nephrology, Ha Emek Medical Center, Afula 18101, Israel
Int J Artif Organs 30:501-12. 2007..Intensive research is required to define the best environmental conditions to take advantage of this plasticity and make the peritoneal mesothelium an actual option to be applied in regenerative medicine... - Iron deficiency is a common cause of anemia in chronic kidney disease and can often be corrected with intravenous ironLazaro Gotloib
Department of Nephrology and Hypertension, Ha Emek Medical Center, Afula, Israel
J Nephrol 19:161-7. 2006..The purpose of this work was to study the effects of intravenous (i.v.) iron administration (ferric gluconate - Ferrlecit) on hemoglobin (Hb) of patients with CKD... - The impact of peritoneal dialysis upon quality of life and mortality of patients with end-stage congestive heart failureLazaro Gotloib
Department of Nephrology, Ha Emek Medical Center, Afula, Israel
Contrib Nephrol 150:247-53. 2006..Use of automated peritoneal dialysis resulted in a significantly improved quality of life and survival... - Repopulation of the mesothelial monolayer during long-term experimental peritoneal dialysisLazaro Gotloib
Department of Nephrology, Ha Emek Medical Center, Afula, Israel
Contrib Nephrol 150:54-61. 2006..This study describes repopulation of a 'doughnut' like mesothelial ring exfoliated from the anterior liver surface of rats... - Peritoneal dialysis in refractory end-stage congestive heart failure: a challenge facing a no-win situationLazaro Gotloib
Center for Experimental Nephrology, Ha Emek Medical Center, Afula 18101, Israel
Nephrol Dial Transplant 20:vii32-6. 2005..Peritoneal dialysis applied to CHF patients with or without renal impairment showed clinical functional improvement... - A short review of experimental peritoneal sclerosis: from mice to menL Gotloib
Department of Nephrology, Hypertension and the Research Center for Experimental Nephrology, Ha Emek Medical Center, Afula 18101, Israel
Int J Artif Organs 28:97-104. 2005..It is concluded that peritoneal sclerosis derives mostly from sustained oxidative injury to the peritoneal membrane. Loss of the mesothelial monolayer is the first step in the chain of events leading to this complication... - Acute oxidative stress induces peritoneal hyperpermeability, mesothelial loss, and fibrosisLazaro Gotloib
Department of Nephrology and Hypertension, Ha Emek Medical Center, Afula, Israel
J Lab Clin Med 143:31-40. 2004.... - Osmotic agents hamper mesothelial repopulation as seen in the doughnut in vivo modelLazaro Gotloib
Department of Nephrology and Hypertension and the Research Centerfor Experimental Nephrology, Ha Emek Medical Center, Afula, Israel
Perit Dial Int 25:S26-30. 2005..Conversely, the eventual detrimental effects upon mesothelial cell regeneration have awaked less investigative efforts than those focused on injury... - Icodextrin-induced lipid peroxidation disrupts the mesothelial cell cycle engineLazaro Gotloib
Department of Nephrology and Hypertension and the Research Center for Experimental Nephrology, Ha Emek Medical Center, Afula, Israel
Free Radic Biol Med 34:419-28. 2003..The 7.5% icodextrin dialysis fluid induces through lipid peroxidation substantial genomic damage, which, in turn, sets the biological mechanisms leading to protective cellular suicide in motion... - Mesothelial dysplastic changes and lipid peroxidation induced by 7.5% icodextrinLazaro Gotloib
Department of Nephrology and Hypertension and the Research Center for Experimental Nephrology, Ha Emek Medical Center, Afula, Israel
Nephron 92:142-55. 2002..The present investigation exposes the first attempt to investigate the biocompatibility issue in an in vivo and in situ setup... - Protective effect of aminoguanidine upon capillary and submesothelial anionic sitesA Shostak
Department of Nephrology and Hypertension, Ha'Emek Medical Center, Afula, Israel
Microvasc Res 61:166-78. 2001..We conclude that the shielding effect of aminoguanidine upon the permselectivity capabilities of the endothelial and mesothelial monolayers appears to be connected, basically to the preservation of anionic fixed charges... - Peritoneal transport after long-term exposure to Icodextrin in ratsVictor Frajewicki
Institute of Nephrology and Hypertension, Carmel Medical Center, Haifa, Israel
Nephron 92:174-82. 2002..CONCLUSION: The long-term use of Icodextrin does not affect small molecule transport, but induces changes in the peritoneal protein excretion, especially when Icodextrin and glucose are injected together... - Agents that modulate peritoneal membrane structure and functionJose A Diaz-Buxo
Home Therapies Development, Fresenius Medical Care North America, Lexington Massachusetts, USA
Perit Dial Int 27:16-30. 2007..Nonetheless, there is room for further significant improvement in solution biocompatibility and for compounds that may restore peritoneal function...