D Gothelf

Summary

Affiliation: Tel Aviv University
Country: Israel

Publications

  1. pmc Genotype-phenotype correlation in 22q11.2 deletion syndrome
    Elena Michaelovsky
    Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    BMC Med Genet 13:122. 2012
  2. ncbi request reprint Methylphenidate treatment for attention-deficit/hyperactivity disorder in children and adolescents with velocardiofacial syndrome: an open-label study
    Doron Gothelf
    Feinberg Child Study Center, Schneider Children s Medical Center of Israel, 14 Kaplan Street, PO Box 559, Petah Tiqwa, Israel 49202
    J Clin Psychiatry 64:1163-9. 2003
  3. ncbi request reprint Obsessive-compulsive disorder in patients with velocardiofacial (22q11 deletion) syndrome
    Doron Gothelf
    Behavioral Genetics Clinic, Schneider Children s Medical Center of Israel, 14 Kaplan Street, PO Box 559, Petah Tiqwa 49202, Israel
    Am J Med Genet B Neuropsychiatr Genet 126:99-105. 2004
  4. ncbi request reprint Genetic, developmental, and physical factors associated with attention deficit hyperactivity disorder in patients with velocardiofacial syndrome
    Doron Gothelf
    Behavioral Genetics Clinic, Feinberg Child Study Center, Schneider Children s Medical Center of Israel, 14 Kaplan Street, PO Box 559, Petah Tiqwa 49202, Israel
    Am J Med Genet B Neuropsychiatr Genet 126:116-21. 2004
  5. ncbi request reprint Abnormal cortical activation during response inhibition in 22q11.2 deletion syndrome
    Doron Gothelf
    The Behavioral Neurogenetics Center, Child Psychiatry Department, Schneider Children s Medical Center of Israel, Petah Tiqwa, Israel
    Hum Brain Mapp 28:533-42. 2007
  6. ncbi request reprint Schizophrenia in adolescent twins: a case study
    Doron Gothelf
    Behavioral Genetic Clinic, Feinberg Child Study Center, Schneider Children s Medical Center of Israel, 14 Kaplan St, POB 559, Petah Tiqwa 49202, Israel
    Isr J Psychiatry Relat Sci 41:54-60. 2004
  7. pdf Risk factors for the emergence of psychotic disorders in adolescents with 22q11.2 deletion syndrome
    Doron Gothelf
    Department of Child Psychiatry, Schneider Children s Medical Center of Israel, Petah Tiqwa, Israel 49202
    Am J Psychiatry 164:663-9. 2007
  8. ncbi request reprint Follow-up of preschool children with severe emotional and behavioral symptoms
    Doron Gothelf
    Feinberg Child Study Center, Schneider Children s Medical Center of Israel, Petah Tiqwa, Israel
    Isr J Psychiatry Relat Sci 43:16-20. 2006
  9. ncbi request reprint Hyperacusis in Williams syndrome: characteristics and associated neuroaudiologic abnormalities
    D Gothelf
    Behavioral Neurogenetics Center, Schneider Children s Medical Center of Israel, Petah Tiqwa, Israel
    Neurology 66:390-5. 2006
  10. ncbi request reprint Cognition, psychosocial adjustment and coping in familial cases of velocardiofacial syndrome
    D Gothelf
    The Behavioral Neurogenetics Center, Schneider Children s Medical Center of Israel, Petah Tiqwa, Israel
    J Neural Transm 114:1495-501. 2007

Detail Information

Publications39

  1. pmc Genotype-phenotype correlation in 22q11.2 deletion syndrome
    Elena Michaelovsky
    Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    BMC Med Genet 13:122. 2012
    ..We explored the genotype-phenotype relationship in a relatively large 22q11.2DS cohort treated and monitored in our clinic using comprehensive clinical evaluation and detailed molecular characterization of the deletion...
  2. ncbi request reprint Methylphenidate treatment for attention-deficit/hyperactivity disorder in children and adolescents with velocardiofacial syndrome: an open-label study
    Doron Gothelf
    Feinberg Child Study Center, Schneider Children s Medical Center of Israel, 14 Kaplan Street, PO Box 559, Petah Tiqwa, Israel 49202
    J Clin Psychiatry 64:1163-9. 2003
    ..Indeed, clinicians have commonly avoided the use of methylphenidate in children with VCFS because of concerns about ineffectiveness or psychotic exacerbation...
  3. ncbi request reprint Obsessive-compulsive disorder in patients with velocardiofacial (22q11 deletion) syndrome
    Doron Gothelf
    Behavioral Genetics Clinic, Schneider Children s Medical Center of Israel, 14 Kaplan Street, PO Box 559, Petah Tiqwa 49202, Israel
    Am J Med Genet B Neuropsychiatr Genet 126:99-105. 2004
    ..2%) had psychotic disorder. The results of our study suggest that there is a strong association between VCFS and early-onset OCD. This finding may be significant in the understanding of the underlying genetic basis of OCD...
  4. ncbi request reprint Genetic, developmental, and physical factors associated with attention deficit hyperactivity disorder in patients with velocardiofacial syndrome
    Doron Gothelf
    Behavioral Genetics Clinic, Feinberg Child Study Center, Schneider Children s Medical Center of Israel, 14 Kaplan Street, PO Box 559, Petah Tiqwa 49202, Israel
    Am J Med Genet B Neuropsychiatr Genet 126:116-21. 2004
    ..These findings indicate that ADHD in VCFS has a genetic contribution and the patients' VCFS-related developmental factors and physical illnesses play a lesser role...
  5. ncbi request reprint Abnormal cortical activation during response inhibition in 22q11.2 deletion syndrome
    Doron Gothelf
    The Behavioral Neurogenetics Center, Child Psychiatry Department, Schneider Children s Medical Center of Israel, Petah Tiqwa, Israel
    Hum Brain Mapp 28:533-42. 2007
    ..2DS may recruit additional cingulate activation for tasks requiring attention and inhibition. 22q11.2DS is a unique model for learning about the deleterious effects of decreased dosage of the COMT gene on brain function...
  6. ncbi request reprint Schizophrenia in adolescent twins: a case study
    Doron Gothelf
    Behavioral Genetic Clinic, Feinberg Child Study Center, Schneider Children s Medical Center of Israel, 14 Kaplan St, POB 559, Petah Tiqwa 49202, Israel
    Isr J Psychiatry Relat Sci 41:54-60. 2004
    ..The recent treatment of identical schizophrenic twins has allowed us to review the literature and revisit some of these issues...
  7. pdf Risk factors for the emergence of psychotic disorders in adolescents with 22q11.2 deletion syndrome
    Doron Gothelf
    Department of Child Psychiatry, Schneider Children s Medical Center of Israel, Petah Tiqwa, Israel 49202
    Am J Psychiatry 164:663-9. 2007
    ..The authors conducted a longitudinal evaluation of adolescents with 22q11.2 deletion syndrome to identify early risk factors for the development of psychotic disorders...
  8. ncbi request reprint Follow-up of preschool children with severe emotional and behavioral symptoms
    Doron Gothelf
    Feinberg Child Study Center, Schneider Children s Medical Center of Israel, Petah Tiqwa, Israel
    Isr J Psychiatry Relat Sci 43:16-20. 2006
    ..The objective of the study was to identify the factors predicting the clinical outcome in preschool inpatients with emotional and behavioral disorders...
  9. ncbi request reprint Hyperacusis in Williams syndrome: characteristics and associated neuroaudiologic abnormalities
    D Gothelf
    Behavioral Neurogenetics Center, Schneider Children s Medical Center of Israel, Petah Tiqwa, Israel
    Neurology 66:390-5. 2006
    ..Hyperacusis and phonophobia are common, debilitating symptoms in Williams syndrome (WS), yet little is known about their underlying audiologic and neurologic processes...
  10. ncbi request reprint Cognition, psychosocial adjustment and coping in familial cases of velocardiofacial syndrome
    D Gothelf
    The Behavioral Neurogenetics Center, Schneider Children s Medical Center of Israel, Petah Tiqwa, Israel
    J Neural Transm 114:1495-501. 2007
    ..Thus, although familial VCFS seems to be associated with a milder physical phenotype than nonfamilial VCFS, the neuropsychiatric deficits are significant in both types, at all ages...
  11. ncbi request reprint Velocardiofacial syndrome
    Doron Gothelf
    Department of Child Psychiatry, Behavioral Neurogenetics Center, Schneider Children s Medical Center of Israel, Petah Tiqwa, Israel 49202
    Child Adolesc Psychiatr Clin N Am 16:677-93. 2007
    ..There is an urgent need to conduct treatment trials in this high-risk population...
  12. pmc Association between cerebral shape and social use of language in Williams syndrome
    Doron Gothelf
    Behavioral Neurogenetics Center, Department of Child Psychiatry, Schneider Children s Medical Center of Israel, Petah Tiqwa, Israel
    Am J Med Genet A 146:2753-61. 2008
    ....
  13. ncbi request reprint Weight gain associated with increased food intake and low habitual activity levels in male adolescent schizophrenic inpatients treated with olanzapine
    Doron Gothelf
    Behavioral Genetic Clinic, Richard E Feinberg Department of Psychiatry, Schneider Children s Medical Center of Israel, Petah Tiqwa
    Am J Psychiatry 159:1055-7. 2002
    ..The authors studied weight gain mechanisms and energy balance in patients treated with olanzapine...
  14. doi request reprint Genes, brain development and psychiatric phenotypes in velo-cardio-facial syndrome
    Doron Gothelf
    Feinberg Department of Child Psychiatry, The Behavioral Neurogenetics Center, Schneider Children s Medical Center of Israel, Petah Tiqwa, Israel
    Dev Disabil Res Rev 14:59-68. 2008
    ..The other genes and environmental factors that shape the unique neuropsychiatric phenotype of VCFS are yet to be discovered...
  15. doi request reprint Psychiatric morbidity with focus on obsessive-compulsive disorder in an Israeli cohort of adolescents with mild to moderate mental retardation
    Doron Gothelf
    The Behavioral Neurogenetics Center, Feinberg Department of Child Psychiatry, Schneider Children s Medical Center of Israel, Petah Tikva, Israel
    J Neural Transm 115:929-36. 2008
    ..Further studies are required in adolescents with mental retardation to better delineate psychiatric morbidities and their appropriate treatment in this at-risk population...
  16. pmc Developmental trajectories of brain structure in adolescents with 22q11.2 deletion syndrome: a longitudinal study
    Doron Gothelf
    The Behavioral Neurogenetics Center, Child Psychiatry Department, Schneider Children s Medical Center of Israel, Petah Tiqwa, Israel
    Schizophr Res 96:72-81. 2007
    ..2DS varies from that observed in healthy controls. Further longitudinal studies are likely to elucidate brain developmental trajectories in 22q11.2DS and their association to psychotic disorders and cognitive deficits in this population...
  17. ncbi request reprint Pilot study: fluvoxamine treatment for depression and anxiety disorders in children and adolescents with cancer
    Doron Gothelf
    Feinberg Department of Child Psychiatry, Schneider Children s Medical Center of Israel, Petah Tiqwa, Israel
    J Am Acad Child Adolesc Psychiatry 44:1258-62. 2005
    ..To evaluate the safety, tolerability, and benefit of fluvoxamine for the treatment of major depressive disorder or anxiety disorders in children and adolescents with cancer...
  18. ncbi request reprint Association of the low-activity COMT 158Met allele with ADHD and OCD in subjects with velocardiofacial syndrome
    Doron Gothelf
    The Behavioral Neurogenetics Center, Feinberg Child Study Center, Schneider Children s Medical Center of Israel, Petah Tiqwa 49202, Israel
    Int J Neuropsychopharmacol 10:301-8. 2007
    ..Future longitudinal studies focusing on additional COMT polymorphic sites and other candidate genes from the deleted region will elucidate the molecular pathways leading to schizophrenia and other psychiatric disorders in VCFS...
  19. ncbi request reprint Clinical characteristics of schizophrenia associated with velo-cardio-facial syndrome
    D Gothelf
    Geha Psychiatric Hospital, Petah Tiqwa, Israel
    Schizophr Res 35:105-12. 1999
    ..The implications of this study for psychiatric phenotype, nosology, disease mechanism, and possible new treatments in the future are discussed...
  20. doi request reprint Serotonin transporter polymorphism (5-HTTLPR) and citalopram effectiveness and side effects in children with depression and/or anxiety disorders
    Sefi Kronenberg
    Feinberg Child Study Center, Schneider s Children s Medical Center of Israel and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    J Child Adolesc Psychopharmacol 17:741-50. 2007
    ....
  21. doi request reprint Effectiveness and tolerability of citalopram for the treatment of depression and anxiety disorders in children and adolescents: an open-label study
    Shella Schirman
    Feinberg Child Study Center, Schneider Children s Medical Center of Israel and Sackler Faculty of Medicine, Tel Aviv University, 14 Kaplan Street, 49202, Petach Tikva, Tel Aviv, Israel
    J Neural Transm 117:139-45. 2010
    ..No increase in suicidality was observed during the study. Citalopram was moderately effective, generally well tolerated and safe for the acute treatment of depressed and anxious children and adolescents...
  22. ncbi request reprint Measurement of aggression in psychiatric patients
    D Gothelf
    Geha Psychiatric Hospital, Petah Tiqwa, Israel
    Psychiatry Res 71:83-95. 1997
    ..g. state vs. trait aggression, dynamic or biological aspects of aggression) and the target population. Practical suggestions in this regard are offered...
  23. ncbi request reprint DRD4 exon III polymorphism and response to risperidone in Israeli adolescents with schizophrenia: a pilot pharmacogenetic study
    Gil Zalsman
    Adolescent Inpatient Department, Geha Mental Health Center, Rabin Medical Center, Petach Tikva 49100, Israel
    Eur Neuropsychopharmacol 13:183-5. 2003
    ..0/4, P=0.11). Studies in larger groups of adolescent schizophrenia patients are warranted to clarify the possible association between DRD4 exon III repeat alleles and the response to risperidone...
  24. ncbi request reprint Life events and personality factors in children and adolescents with obsessive-compulsive disorder and other anxiety disorders
    Doron Gothelf
    Richard E Feinberg Department of Psychiatry, Schneider Children s Medical Center of Israel, Petah Tiqwa, and Sacker Faculty of Medicine, Tel Aviv University, Israel
    Compr Psychiatry 45:192-8. 2004
    ..Thus, quantity, quality, and specificity of life events may be associated with AD in young people, especially OCD. This association may be related to the personality characteristic of harm avoidance...
  25. ncbi request reprint Depression and suicidal behavior in adolescent inpatients with obsessive compulsive disorder
    Alan Apter
    Feinberg Child Study Center, Schneider Children s Medical Center of Israel, 14 Kaplan Street, Petach Tikva 49202, Israel
    J Affect Disord 75:181-9. 2003
    ..To investigate the prevalence and correlations of suicidal behavior in obsessive compulsive disorder (OCD) among adolescent psychiatric inpatients...
  26. ncbi request reprint Autosomal recessive mental retardation syndrome with anterior maxillary protrusion and strabismus: MRAMS syndrome
    Lina Basel-Vanagaite
    Department of Medical Genetics, Schneider Children s Medical Center of Israel and Rabin Medical Center, Beilinson Campus, Petah Tikva, Israel
    Am J Med Genet A 143:1687-91. 2007
    ....
  27. ncbi request reprint Auditory and visual processing in Williams syndrome
    Omer Zarchi
    Behavioral Neurogenetics Center, Feinberg Department of Child Psychiatry, Schneider Children s Medical Center of Israel, Petah Tikva, Israel
    Isr J Psychiatry Relat Sci 47:125-31. 2010
    ..The findings may also have important implications for other developmental psychopathologies, such as autism, schizophrenia and attention deficit hyperactivity disorder...
  28. ncbi request reprint Relationship between self-disclosure and serious suicidal behavior
    A Apter
    Department of Psychiatry, Geha Psychiatric Hospital, Petah Tiqwa, Israel
    Compr Psychiatry 42:70-5. 2001
    ..Further studies are needed to investigate related variables, wider patients groups, and the use of different instruments...
  29. pmc Neuroanatomy of fragile X syndrome is associated with aberrant behavior and the fragile X mental retardation protein (FMRP)
    Doron Gothelf
    Behavioral Neurogenetics Center, Child Psychiatry Department, Schneider Children s Medical Center of Israel, Petah Tiqwa
    Ann Neurol 63:40-51. 2008
    ..To determine how neuroanatomic variation in children and adolescents with fragile X syndrome is linked to reduced levels of the fragile X mental retardation-1 protein and to aberrant cognition and behavior...
  30. ncbi request reprint Hyperglycemia from olanzapine treatment in adolescents
    Yuval Bloch
    Shalvata Mental Health Center, Hod Hasharon, PO Box 94, Israel
    J Child Adolesc Psychopharmacol 13:97-102. 2003
    ..quot; We consider the findings of the presented case series as justification for regular metabolic follow-up for apparently healthy adolescents receiving olanzapine therapy...
  31. ncbi request reprint COMT genotype predicts longitudinal cognitive decline and psychosis in 22q11.2 deletion syndrome
    Doron Gothelf
    Center for Interdisciplinary Brain Sciences Research, Stanford University School of Medicine, 401 Quarry Road, Stanford, California 94305 5795, USA
    Nat Neurosci 8:1500-2. 2005
    ..The 22q11.2 deletion syndrome is a promising model for identifying biomarkers related to the development of schizophrenia...
  32. ncbi request reprint Psychosocial situations, quality of depression and schizophrenia in adolescents
    Gil Zalsman
    Adolescent Inpatient Unit, Geha Psychiatric Hospital, Petah Tiqva, and Tel Aviv University, Tel Aviv, Israel
    Psychiatry Res 129:149-57. 2004
    ..Environmental factors play an important role in the course of schizophrenia in adolescents and should remain a focus of study. Object relations theory may be of heuristic value in the investigation of these factors...
  33. ncbi request reprint Weight gain associated with olanzapine and risperidone in adolescent patients: a comparative prospective study
    Gidi Ratzoni
    Adolescent Inpatient Unit, Shalvata Mental Health Center, Hod Hasharon, Israel
    J Am Acad Child Adolesc Psychiatry 41:337-43. 2002
    ..To evaluate weight gain associated with olanzapine, risperidone, and haloperidol treatment and its clinical risk factors in adolescent patients...
  34. ncbi request reprint A follow-up study of adolescent attempted suicide in Israel
    Ilana Farbstein
    Department of Child and Adolescent Psychiatry, Rivka Ziv Hospital, Safed, Israel
    J Am Acad Child Adolesc Psychiatry 41:1342-9. 2002
    ..2) To compare the prognosis of those attempters who received intensive psychiatric inpatient evaluation in a general hospital with the prognosis of those who received emergency room treatment only...
  35. ncbi request reprint Association between a common haplotype in the COMT gene region and psychiatric disorders in individuals with 22q11.2DS
    Elena Michaelovsky
    Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    Int J Neuropsychopharmacol 11:351-63. 2008
    ..2DS and supports the hypothesis that COMT gene variations contribute to genetic predisposition to psychiatric disorders in the general population...
  36. ncbi request reprint Comparison of the suicidal behavior of adolescent inpatients with borderline personality disorder and major depression
    Netta Horesh
    Department of Psychology, Bar Ilan University, Ramat Gan, Israel
    J Nerv Ment Dis 191:582-8. 2003
    ..We conclude that the nature of suicidal behavior in adolescents with BPD differs from that seen in MDD with respect to the role of anger and aggression...
  37. ncbi request reprint The contribution of novel brain imaging techniques to understanding the neurobiology of mental retardation and developmental disabilities
    Doron Gothelf
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California 94305 5719, USA
    Ment Retard Dev Disabil Res Rev 11:331-9. 2005
    ....
  38. ncbi request reprint Sexual function and behavior in social phobia
    Liron Bodinger
    Geha Psychiatric Hospital, Petah Tiqva, Israel
    J Clin Psychiatry 63:874-9. 2002
    ..The aim of the present study was to evaluate sexual function and behavior in patients with social phobia compared with mentally healthy subjects...
  39. ncbi request reprint Pediatric palliative care
    Doron Gothelf
    N Engl J Med 351:301-2; author reply 301-2. 2004