Irit Gil-Ad

Summary

Affiliation: Tel Aviv University
Country: Israel

Publications

  1. ncbi request reprint Characterization of phenothiazine-induced apoptosis in neuroblastoma and glioma cell lines: clinical relevance and possible application for brain-derived tumors
    Irit Gil-Ad
    Laboratory of Biological Psychiatry, Felsenstein Medical Research Center, Campus Rabin, Petah Tiqva 49100, Israel, and Sackler School of Medicine, Tel Aviv University, Ramat Aviv, Israel
    J Mol Neurosci 22:189-98. 2004
  2. ncbi request reprint Evaluation of the potential anti-cancer activity of the antidepressant sertraline in human colon cancer cell lines and in colorectal cancer-xenografted mice
    Irit Gil-Ad
    Laboratory of Biological Psychiatry, Felsentein Medical Research Center, Sackler Faculty of Medicine, Tel Aviv University and Campus Rabin, Petah Tikva 49100, Israel
    Int J Oncol 33:277-86. 2008
  3. ncbi request reprint Phenothiazines induce apoptosis in a B16 mouse melanoma cell line and attenuate in vivo melanoma tumor growth
    Irit Gil-Ad
    Laboratory of Biological Psychiatry, Felsenstein Medical Research Center, Rabin Medical Center Beilinson Campus, Petah Tiqva, Israel
    Oncol Rep 15:107-12. 2006
  4. ncbi request reprint Differential induction of apoptosis by antidepressants in glioma and neuroblastoma cell lines: evidence for p-c-Jun, cytochrome c, and caspase-3 involvement
    Yechiel Levkovitz
    Laboratory of Biological Psychiatry, Felsenstein Medical Research Center, Tel Aviv University, Rabin Campus, Petah Tiqva 49100, Israel
    J Mol Neurosci 27:29-42. 2005
  5. ncbi request reprint Immunomodulatory effect of selective serotonin reuptake inhibitors (SSRIs) on human T lymphocyte function and gene expression
    Michal Taler
    Laboratory of Biological Psychiatry, Felsenstein Medical Research Center and Sackler Faculty of Medicine, Tel Aviv University, Israel
    Eur Neuropsychopharmacol 17:774-80. 2007
  6. doi request reprint Evidence for an inhibitory immunomodulatory effect of selected antidepressants on rat splenocytes: possible relevance to depression and hyperactive-immune disorders
    Michal Taler
    Laboratory of Biological Psychiatry, Felsenstein Medical Research Center and Sackler Faculty of Medicine, Tel Aviv University, Israel
    Int Immunopharmacol 8:526-33. 2008
  7. doi request reprint The effects of reboxetine treatment on depression-like behavior, brain neurotrophins, and ERK expression in rats exposed to chronic mild stress
    Maya First
    Laboratory of Biological Psychiatry, Felsenstein Medical Research Center and Sackler Faculty of Medicine, Tel Aviv University, Petach Tikva 49100, Israel
    J Mol Neurosci 50:88-97. 2013
  8. doi request reprint The immunomodulatory effect of the antidepressant sertraline in an experimental autoimmune encephalomyelitis mouse model of multiple sclerosis
    Michal Taler
    Laboratory of Biological Psychiatry, Felsenstein Medical Research Center, Tel Aviv University, Petah Tikva, Israel
    Neuroimmunomodulation 18:117-22. 2011
  9. ncbi request reprint In vitro novel combinations of psychotropics and anti-cancer modalities in U87 human glioblastoma cells
    Sivan Tzadok
    Felsenstein Medical Research Center, Rabin Medical Center, Petah Tikva 49100, Israel
    Int J Oncol 37:1043-51. 2010
  10. doi request reprint Proapoptotic and chemosensitizing effects of selective serotonin reuptake inhibitors on T cell lymphoma/leukemia (Jurkat) in vitro
    Ben Hayman Amit
    Laboratory of Biological Psychiatry, Felsenstein Medical Research Center, Rabin Medical Center, Petah Tikva, Israel
    Eur Neuropsychopharmacol 19:726-34. 2009

Collaborators

Detail Information

Publications23

  1. ncbi request reprint Characterization of phenothiazine-induced apoptosis in neuroblastoma and glioma cell lines: clinical relevance and possible application for brain-derived tumors
    Irit Gil-Ad
    Laboratory of Biological Psychiatry, Felsenstein Medical Research Center, Campus Rabin, Petah Tiqva 49100, Israel, and Sackler School of Medicine, Tel Aviv University, Ramat Aviv, Israel
    J Mol Neurosci 22:189-98. 2004
    ..Overall, the marked apoptotic effect of phenothiazines in brain-derived cancer cells, and the low sensitivity of primary brain tissue suggest the potential use of selected agents as therapeutic modalities in brain cancer...
  2. ncbi request reprint Evaluation of the potential anti-cancer activity of the antidepressant sertraline in human colon cancer cell lines and in colorectal cancer-xenografted mice
    Irit Gil-Ad
    Laboratory of Biological Psychiatry, Felsentein Medical Research Center, Sackler Faculty of Medicine, Tel Aviv University and Campus Rabin, Petah Tikva 49100, Israel
    Int J Oncol 33:277-86. 2008
    ..Since SSRI therapy is frequently indicated in cancer patients, the use of sertraline in colon cancer patients with co-morbidity of depression seems attractive...
  3. ncbi request reprint Phenothiazines induce apoptosis in a B16 mouse melanoma cell line and attenuate in vivo melanoma tumor growth
    Irit Gil-Ad
    Laboratory of Biological Psychiatry, Felsenstein Medical Research Center, Rabin Medical Center Beilinson Campus, Petah Tiqva, Israel
    Oncol Rep 15:107-12. 2006
    ..resulted in the reduction of lung tumor burden and an increase in mice survival. In conclusion, several phenothiazines, and particularly thioridazine, induced apoptosis of B16 melanoma cells and demonstrated in vivo anti-tumor activity...
  4. ncbi request reprint Differential induction of apoptosis by antidepressants in glioma and neuroblastoma cell lines: evidence for p-c-Jun, cytochrome c, and caspase-3 involvement
    Yechiel Levkovitz
    Laboratory of Biological Psychiatry, Felsenstein Medical Research Center, Tel Aviv University, Rabin Campus, Petah Tiqva 49100, Israel
    J Mol Neurosci 27:29-42. 2005
    ..The high sensitivity to these drugs of the cancer cell, compared with primary brain tissue, suggests the potential use of these agents in the treatment of brain-derived tumors...
  5. ncbi request reprint Immunomodulatory effect of selective serotonin reuptake inhibitors (SSRIs) on human T lymphocyte function and gene expression
    Michal Taler
    Laboratory of Biological Psychiatry, Felsenstein Medical Research Center and Sackler Faculty of Medicine, Tel Aviv University, Israel
    Eur Neuropsychopharmacol 17:774-80. 2007
    ..These findings reveal an immunomodulatory effect of the SSRIs paroxetine and sertraline in human T cells. The clinical implications of our findings merit further investigation...
  6. doi request reprint Evidence for an inhibitory immunomodulatory effect of selected antidepressants on rat splenocytes: possible relevance to depression and hyperactive-immune disorders
    Michal Taler
    Laboratory of Biological Psychiatry, Felsenstein Medical Research Center and Sackler Faculty of Medicine, Tel Aviv University, Israel
    Int Immunopharmacol 8:526-33. 2008
    ..These findings reveal the immunomodulatory effect of the selected antidepressants. These data suggest a novel use of antidepressants or their derivatives...
  7. doi request reprint The effects of reboxetine treatment on depression-like behavior, brain neurotrophins, and ERK expression in rats exposed to chronic mild stress
    Maya First
    Laboratory of Biological Psychiatry, Felsenstein Medical Research Center and Sackler Faculty of Medicine, Tel Aviv University, Petach Tikva 49100, Israel
    J Mol Neurosci 50:88-97. 2013
    ..In conclusion, our study shows that BDNF, its receptor TrkB, and ERK participate in the neurobiological response to chronic stress and in the molecular and cellular activities of REB in the hippocampus...
  8. doi request reprint The immunomodulatory effect of the antidepressant sertraline in an experimental autoimmune encephalomyelitis mouse model of multiple sclerosis
    Michal Taler
    Laboratory of Biological Psychiatry, Felsenstein Medical Research Center, Tel Aviv University, Petah Tikva, Israel
    Neuroimmunomodulation 18:117-22. 2011
    ..We have previously demonstrated the immunomodulatory activity of some selective serotonin reuptake inhibitors...
  9. ncbi request reprint In vitro novel combinations of psychotropics and anti-cancer modalities in U87 human glioblastoma cells
    Sivan Tzadok
    Felsenstein Medical Research Center, Rabin Medical Center, Petah Tikva 49100, Israel
    Int J Oncol 37:1043-51. 2010
    ..Thus, it seems that further in vivo studies combining imatinib with psychotropic agents, especially fluoxetine and sertraline, are warranted...
  10. doi request reprint Proapoptotic and chemosensitizing effects of selective serotonin reuptake inhibitors on T cell lymphoma/leukemia (Jurkat) in vitro
    Ben Hayman Amit
    Laboratory of Biological Psychiatry, Felsenstein Medical Research Center, Rabin Medical Center, Petah Tikva, Israel
    Eur Neuropsychopharmacol 19:726-34. 2009
    ..5 microM) markedly enhanced the effects of both vincristine and doxorubicin, suggesting SSRI antidepressants as potential new chemosensitizers in chemotherapeutic regimens, pending further in vivo research...
  11. doi request reprint The effects of fluoxetine treatment in a chronic mild stress rat model on depression-related behavior, brain neurotrophins and ERK expression
    Maya First
    Laboratory of Biological Psychiatry, Felsenstein Medical Research Center and Sackler Faculty of Medicine, Tel Aviv University, Beilinson Campus, 49100 Petah Tikva, Israel
    J Mol Neurosci 45:246-55. 2011
    ..This study suggests that IGF-1R and ERK may have a role in mediating the neural stress response and the mode of action of FLX. This role seems to be independent of the BDNF alterations...
  12. ncbi request reprint Antidepressants induce cellular insulin resistance by activation of IRS-1 kinases
    Yechiel Levkovitz
    Laboratory of Biological Psychiatry, Felsenstein Medical Research Center, Rabin Campus, Petah Tiqva, Israel
    Mol Cell Neurosci 36:305-12. 2007
    ..These results implicate selected SSRIs as inhibitors of insulin signaling and as potential inducers of cellular insulin resistance...
  13. ncbi request reprint Relationship between antidepressants and IGF-1 system in the brain: possible role in cognition
    Nurit Grunbaum-Novak
    Lab of Biological Psychiatry, Felsenstein Medical Research Center and Sackler Faculty of Medicine, Tel Aviv University, Petach Tikva, Israel
    Eur Neuropsychopharmacol 18:431-8. 2008
    ..FLX did not affect cognitive performance. Thus, repeated FLX treatment leads to upregulation of IGF-1 system is FC. It is possible that FLX affect FC neuroplasticity through activation of the IGF-1 system...
  14. doi request reprint A mutual prodrug ester of GABA and perphenazine exhibits antischizophrenic efficacy with diminished extrapyramidal effects
    Abraham Nudelman
    Department of Chemistry, Bar Ilan University, Ramat Gan, Israel
    J Med Chem 51:2858-62. 2008
    ..Thus, 3 (BL-1020) constitutes a prototype of novel antipsychotics possessing GABAergic activity. A phase II study is in progress...
  15. doi request reprint Dominant negative DISC1 mutant mice display specific social behaviour deficits and aberration in BDNF and cannabinoid receptor expression
    Ayelet Kaminitz
    Biological Psychiatry Lab, Felsenstein Medical Research Center, Beilinson Campus, Sackler Faculty of Medicine, Tel Aviv University, Israel
    World J Biol Psychiatry 15:76-82. 2014
    ..Conclusions. We describe novel behavioural and biochemical abnormalities in the DN-DISC1 mouse model of schizophrenia. The data shows for the first time a possible link between DISC1 mutation and the cannabinoid system. ..
  16. doi request reprint Immunomodulatory effect of sertraline in a rat model of rheumatoid arthritis
    Ehud Baharav
    Laboratory of Joint Pathophysiology and Inflammation, Department of Medicine C, Rabin Medical Center, Petach Tikva, Israel
    Neuroimmunomodulation 19:309-18. 2012
    ..SSRIs are the preferred treatment for major depressive disorder (MDD). A high rate of MDD is observed in rheumatoid arthritis (RA) patients. The aim of this study was to evaluate immunological effects of SSRIs in a rat model of RA...
  17. ncbi request reprint Modulation of brain insulin-like growth factor I (IGF-I) binding sites and hypothalamic GHRH and somatostatin levels by exogenous growth hormone and IGF-I in juvenile rats
    Rina Eshet
    Laboratory of Endocrinology and Diabetes, Felsenstein Medical Research Center, Petah Tikva, Israel
    J Mol Neurosci 22:179-88. 2004
    ..Because IGF-I is a potent neurotrophic agent, this effect may have important implications for states of neurodegenerative diseases...
  18. doi request reprint Mesenchymal stem cells protect from sub-chronic phencyclidine insult in vivo and counteract changes in astrocyte gene expression in vitro
    Ran Barzilay
    Laboratory of Neuroscience, Felsenstein Medical Research Center, Rabin Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Israel Research Unit at Geha Mental Health Center, Israel Electronic address
    Eur Neuropsychopharmacol 23:1115-23. 2013
    ..The mechanism underlying the beneficial behavioral effect may involve modulation of host astrocyte functioning, including glutamate processing and antioxidant capacity...
  19. doi request reprint Neuroprotective and procognitive effects of sertraline: in vitro and in vivo studies
    Michal Taler
    Laboratory of Biological Psychiatry, Felsenstein Medical Research Center and Sackler Faculty of Medicine, Tel Aviv University, Israel
    Neurosci Lett 550:93-7. 2013
    ..Sertraline treatment resulted in up-regulation of brain BDNF, phospho-ERK and Bcl-2 that may be involved in the pro-cognitive effect of sertraline...
  20. doi request reprint Gamma-aminobutyric acid amides of nortriptyline and fluoxetine display improved pain suppressing activity
    Ada Rephaeli
    Laboratory of Pharmacology and Experimental Oncology, Felsenstein Medical Research Center, Sackler Faculty of Medicine, Tel Aviv University, Ramat Aviv, Israel
    J Med Chem 52:3010-7. 2009
    ..Amide 1 was most efficacious in lowering cytokine secretion, edema and hyperalgesia induced by formalin and lambda-carrageenan, respectively. Thus, 1 is a promising candidate for the treatment of pain...
  21. ncbi request reprint Olanzapine-induced weight gain in patients with first-episode schizophrenia: a double-blind, placebo-controlled study of fluoxetine addition
    Michael Poyurovsky
    Research Unit, Tirat Carmel Mental Health Center, Israel
    Am J Psychiatry 159:1058-60. 2002
    ....
  22. ncbi request reprint Attenuating effect of reboxetine on appetite and weight gain in olanzapine-treated schizophrenia patients: a double-blind placebo-controlled study
    Michael Poyurovsky
    Research Unit, Tirat Carmel Mental Health Center, P O Box 9, Tirat Carmel, 30200, Israel
    Psychopharmacology (Berl) 192:441-8. 2007
    ..In the present study, we sought to replicate our preliminary findings, which indicated that coadministration of the selective norepinephrine reuptake inhibitor reboxetine attenuates olanzapine-induced weight gain...
  23. ncbi request reprint The effect of famotidine addition on olanzapine-induced weight gain in first-episode schizophrenia patients: a double-blind placebo-controlled pilot study
    Michael Poyurovsky
    Research Unit, Tirat Carmel Mental Health Center, 9 Eshkol Street, 30200 Tirat Carmel, Israel
    Eur Neuropsychopharmacol 14:332-6. 2004
    ..In conclusion, famotidine (40 mg/day for 6 weeks) is not effective in preventing/attenuating weight gain in olanzapine-treated first-episode schizophrenia patients...