Amos Frisch

Summary

Affiliation: Tel Aviv University
Country: Israel

Publications

  1. pmc Genotype-phenotype correlation in 22q11.2 deletion syndrome
    Elena Michaelovsky
    Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    BMC Med Genet 13:122. 2012
  2. ncbi request reprint Association of anorexia nervosa with the high activity allele of the COMT gene: a family-based study in Israeli patients
    A Frisch
    Felsenstein Medical Research Center, Petah Tikva, 49 100 Israel
    Mol Psychiatry 6:243-5. 2001
  3. ncbi request reprint Origin and spread of the 1278insTATC mutation causing Tay-Sachs disease in Ashkenazi Jews: genetic drift as a robust and parsimonious hypothesis
    Amos Frisch
    Felsenstein Medical Research Center, Rabin Medical Center, 49100, Petah Tikva, Israel
    Hum Genet 114:366-76. 2004
  4. ncbi request reprint A rare short allele of the serotonin transporter promoter region (5-HTTLPR) found in an aggressive schizophrenic patient of Jewish Libyan origin
    A Frisch
    Laboratory of Biochemical Genetics, Felsenstein Medical Research Center, Rabin Medical Center, Petah Tikva, Israel
    Psychiatr Genet 10:179-83. 2000
  5. doi request reprint Effectiveness and tolerability of citalopram for the treatment of depression and anxiety disorders in children and adolescents: an open-label study
    Shella Schirman
    Feinberg Child Study Center, Schneider Children s Medical Center of Israel and Sackler Faculty of Medicine, Tel Aviv University, 14 Kaplan Street, 49202, Petach Tikva, Tel Aviv, Israel
    J Neural Transm 117:139-45. 2010
  6. doi request reprint Psychiatric disorders and intellectual functioning throughout development in velocardiofacial (22q11.2 deletion) syndrome
    Tamar Green
    Sackler Faculty of Medicine, Tel Aviv University, Israel
    J Am Acad Child Adolesc Psychiatry 48:1060-8. 2009
  7. ncbi request reprint Association between a common haplotype in the COMT gene region and psychiatric disorders in individuals with 22q11.2DS
    Elena Michaelovsky
    Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    Int J Neuropsychopharmacol 11:351-63. 2008
  8. doi request reprint The feasibility and safety of S-adenosyl-L-methionine (SAMe) for the treatment of neuropsychiatric symptoms in 22q11.2 deletion syndrome: a double-blind placebo-controlled trial
    Tamar Green
    The Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    J Neural Transm 119:1417-23. 2012
  9. ncbi request reprint Family-based association study of 5-HT(2A) receptor T102C polymorphism and suicidal behavior in Ashkenazi inpatient adolescents
    Gil Zalsman
    Child and Adolescent Division, Geha Mental Health Center, Petach Tikva, and a Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    Int J Adolesc Med Health 17:231-8. 2005
  10. ncbi request reprint Haplotype analysis of the COMT-ARVCF gene region in Israeli anorexia nervosa family trios
    Elena Michaelovsky
    Felsenstein Medical Research Center, Rabin Medical Center, Petah Tikva, Israel
    Am J Med Genet B Neuropsychiatr Genet 139:45-50. 2005

Collaborators

Detail Information

Publications26

  1. pmc Genotype-phenotype correlation in 22q11.2 deletion syndrome
    Elena Michaelovsky
    Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    BMC Med Genet 13:122. 2012
    ..We explored the genotype-phenotype relationship in a relatively large 22q11.2DS cohort treated and monitored in our clinic using comprehensive clinical evaluation and detailed molecular characterization of the deletion...
  2. ncbi request reprint Association of anorexia nervosa with the high activity allele of the COMT gene: a family-based study in Israeli patients
    A Frisch
    Felsenstein Medical Research Center, Petah Tikva, 49 100 Israel
    Mol Psychiatry 6:243-5. 2001
    ..015). Our study suggests that the COMT gene is associated with genetic susceptibility to AN, and that individuals homozygous for the high activity allele (HH) have a two-fold increased risk for development of the disorder...
  3. ncbi request reprint Origin and spread of the 1278insTATC mutation causing Tay-Sachs disease in Ashkenazi Jews: genetic drift as a robust and parsimonious hypothesis
    Amos Frisch
    Felsenstein Medical Research Center, Rabin Medical Center, 49100, Petah Tikva, Israel
    Hum Genet 114:366-76. 2004
    ..Therefore, the founder effect in a rapidly expanding population arising from a bottleneck provides a robust parsimonious hypothesis explaining the spread of 1278insTATC-linked TSD in AJ individuals...
  4. ncbi request reprint A rare short allele of the serotonin transporter promoter region (5-HTTLPR) found in an aggressive schizophrenic patient of Jewish Libyan origin
    A Frisch
    Laboratory of Biochemical Genetics, Felsenstein Medical Research Center, Rabin Medical Center, Petah Tikva, Israel
    Psychiatr Genet 10:179-83. 2000
    ..The role of the allele in serotonin transport and possible association with disease phenotype should be further investigated...
  5. doi request reprint Effectiveness and tolerability of citalopram for the treatment of depression and anxiety disorders in children and adolescents: an open-label study
    Shella Schirman
    Feinberg Child Study Center, Schneider Children s Medical Center of Israel and Sackler Faculty of Medicine, Tel Aviv University, 14 Kaplan Street, 49202, Petach Tikva, Tel Aviv, Israel
    J Neural Transm 117:139-45. 2010
    ..No increase in suicidality was observed during the study. Citalopram was moderately effective, generally well tolerated and safe for the acute treatment of depressed and anxious children and adolescents...
  6. doi request reprint Psychiatric disorders and intellectual functioning throughout development in velocardiofacial (22q11.2 deletion) syndrome
    Tamar Green
    Sackler Faculty of Medicine, Tel Aviv University, Israel
    J Am Acad Child Adolesc Psychiatry 48:1060-8. 2009
    ..We report the data from two large cohorts of individuals with VCFS from Israel and Western Europe to characterize the neuropsychiatric phenotype from childhood to adulthood in a large sample...
  7. ncbi request reprint Association between a common haplotype in the COMT gene region and psychiatric disorders in individuals with 22q11.2DS
    Elena Michaelovsky
    Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    Int J Neuropsychopharmacol 11:351-63. 2008
    ..2DS and supports the hypothesis that COMT gene variations contribute to genetic predisposition to psychiatric disorders in the general population...
  8. doi request reprint The feasibility and safety of S-adenosyl-L-methionine (SAMe) for the treatment of neuropsychiatric symptoms in 22q11.2 deletion syndrome: a double-blind placebo-controlled trial
    Tamar Green
    The Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    J Neural Transm 119:1417-23. 2012
    ..In conclusion SAMe treatment up to 1,600 mg/day for 6 weeks in 22q11.2DS individuals appears to be safe, well tolerated and with no serious side effects. No significant benefit in depressive or ADHD symptoms was detected...
  9. ncbi request reprint Family-based association study of 5-HT(2A) receptor T102C polymorphism and suicidal behavior in Ashkenazi inpatient adolescents
    Gil Zalsman
    Child and Adolescent Division, Geha Mental Health Center, Petach Tikva, and a Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    Int J Adolesc Med Health 17:231-8. 2005
    ..This study used a family-based method and one homogenous ethnic group to overcome ethnic stratification in order to test this association...
  10. ncbi request reprint Haplotype analysis of the COMT-ARVCF gene region in Israeli anorexia nervosa family trios
    Elena Michaelovsky
    Felsenstein Medical Research Center, Rabin Medical Center, Petah Tikva, Israel
    Am J Med Genet B Neuropsychiatr Genet 139:45-50. 2005
    ..The risk and protective haplotypes may carry molecular variations in the COMT gene or its vicinity that are relevant to the pathophysiology of restrictive anorexia nervosa in the Israeli-Jewish population...
  11. ncbi request reprint DRD4 exon III polymorphism and response to risperidone in Israeli adolescents with schizophrenia: a pilot pharmacogenetic study
    Gil Zalsman
    Adolescent Inpatient Department, Geha Mental Health Center, Rabin Medical Center, Petach Tikva 49100, Israel
    Eur Neuropsychopharmacol 13:183-5. 2003
    ..0/4, P=0.11). Studies in larger groups of adolescent schizophrenia patients are warranted to clarify the possible association between DRD4 exon III repeat alleles and the response to risperidone...
  12. doi request reprint Serotonin transporter polymorphism (5-HTTLPR) and citalopram effectiveness and side effects in children with depression and/or anxiety disorders
    Sefi Kronenberg
    Feinberg Child Study Center, Schneider s Children s Medical Center of Israel and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    J Child Adolesc Psychopharmacol 17:741-50. 2007
    ....
  13. doi request reprint The effect of methylphenidate on prefrontal cognitive functioning, inattention, and hyperactivity in velocardiofacial syndrome
    Tamar Green
    Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    J Child Adolesc Psychopharmacol 21:589-95. 2011
    ..Yet concerns have been raised regarding its safety and efficacy in VCFS. The goal of this study was to examine the safety and efficacy of MPH in children with VCFS...
  14. ncbi request reprint Genetics of suicidal behavior: candidate association genetic approach
    Gil Zalsman
    Geha Mental Health Center, Felsenstein Medical Research Center, Rabin Medical Center, Beilinson Campus, Petach Tikva, Israel
    Isr J Psychiatry Relat Sci 39:252-61. 2002
    ..Recent data from the study of COMT. MAO and serotonin receptors genes polymorphisms are controversial at this stage. Future directions for research includes alternative phenotypes, endo-phenotypes and genome scan...
  15. ncbi request reprint Effect of ADH1B genotype on alcohol consumption in young Israeli Jews
    Baruch Spivak
    Beer Yaa kov Mental Hospital, Tel Aviv, Israel
    Alcohol Clin Exp Res 31:1297-301. 2007
    ..Alcohol consumption is increasing among younger Israeli Jews, reflecting environmental influences. We investigated whether the relationship of ADH1B genotype with alcohol consumption differed between younger and older adult Israelis...
  16. ncbi request reprint Methylphenidate treatment for attention-deficit/hyperactivity disorder in children and adolescents with velocardiofacial syndrome: an open-label study
    Doron Gothelf
    Feinberg Child Study Center, Schneider Children s Medical Center of Israel, 14 Kaplan Street, PO Box 559, Petah Tiqwa, Israel 49202
    J Clin Psychiatry 64:1163-9. 2003
    ..Indeed, clinicians have commonly avoided the use of methylphenidate in children with VCFS because of concerns about ineffectiveness or psychotic exacerbation...
  17. doi request reprint Association of polymorphisms of the serotonergic pathways with clinical traits of impulsive-aggression and suicidality in adolescents: a multi-center study
    Gil Zalsman
    Child and Adolescent Psychiatry Division, Geha Mental Health Center, Petach Tikva, Israel
    World J Biol Psychiatry 12:33-41. 2011
    ..Suicidal behaviour runs in families. This study evaluated association between common polymorphisms in the serotonergic and adrenergic candidate genes (HTR2A, 5HTTLPR, and MAOA) and suicidality, psychopathology and aggression in adolescents...
  18. ncbi request reprint Obsessive-compulsive disorder in patients with velocardiofacial (22q11 deletion) syndrome
    Doron Gothelf
    Behavioral Genetics Clinic, Schneider Children s Medical Center of Israel, 14 Kaplan Street, PO Box 559, Petah Tiqwa 49202, Israel
    Am J Med Genet B Neuropsychiatr Genet 126:99-105. 2004
    ..2%) had psychotic disorder. The results of our study suggest that there is a strong association between VCFS and early-onset OCD. This finding may be significant in the understanding of the underlying genetic basis of OCD...
  19. ncbi request reprint Genetic, developmental, and physical factors associated with attention deficit hyperactivity disorder in patients with velocardiofacial syndrome
    Doron Gothelf
    Behavioral Genetics Clinic, Feinberg Child Study Center, Schneider Children s Medical Center of Israel, 14 Kaplan Street, PO Box 559, Petah Tiqwa 49202, Israel
    Am J Med Genet B Neuropsychiatr Genet 126:116-21. 2004
    ..These findings indicate that ADHD in VCFS has a genetic contribution and the patients' VCFS-related developmental factors and physical illnesses play a lesser role...
  20. ncbi request reprint Association of tetralogy of Fallot with a distinct region of del22q11.2
    Gania Kessler-Icekson
    Basil and Gerald Felsenstein Medical Research Center, Tel Aviv University, Tel Aviv, Israel
    Am J Med Genet 107:294-8. 2002
    ..Our findings support an association between TOF and hemizygosity in 22q11.2, suggesting a distinct region, between markers D22S1638 and COMT, that may harbor TOF susceptibility genes...
  21. ncbi request reprint Specific mutations in the HEXA gene among Iraqi Jewish Tay-Sachs disease carriers: dating of founder ancestor
    Mazal Karpati
    Danek Gertner Institute of Human Genetics, Sheba Medical Center, 52621 Tel Hashomer, Israel
    Neurogenetics 5:35-40. 2004
    ..0-72.6 g] and C1351G arose 80.4 +/- 35.9 g ago (95% CI 44.5-116.3 g). Thus, the estimated dates for introduction of mutations are: 626 +/- 426 A.D. (200-1052 A.D.) for G749T and 442 +/- 1077 B.C. (1519 B.C. to 635 A.D.) for C1351G...
  22. ncbi request reprint Dual contribution of NR2B subunit of NMDA receptor and SK3 Ca(2+)-activated K+ channel to genetic predisposition to anorexia nervosa
    Maya Koronyo-Hamaoui
    The Danek Gertner Institute of Human Genetics, Sheba Medical Center, Tel Hashomer 52621, Israel
    J Psychiatr Res 41:160-7. 2007
    ..8 for the combined NR2B/SK3 genotypes including high-risk alleles). These findings point to the contribution of genes associated with the NMDA-R signaling pathway to predisposition and development of AN...
  23. ncbi request reprint Association of the serotonin transporter promotor polymorphism with suicide attempters with a high medical damage
    Danuta Wasserman
    The National and the Stockholm County Centre for Suicide Research and Prevention of Mental Ill Health, Dep of the Public Health Sciences, Karolinska Institute, Stockholm, Sweden
    Eur Neuropsychopharmacol 17:230-3. 2007
    ..054, df=1, p=0.0026). The results suggest that the S-allele may predispose for suicidal behavior characterized by high determination...
  24. ncbi request reprint Association of the low-activity COMT 158Met allele with ADHD and OCD in subjects with velocardiofacial syndrome
    Doron Gothelf
    The Behavioral Neurogenetics Center, Feinberg Child Study Center, Schneider Children s Medical Center of Israel, Petah Tiqwa 49202, Israel
    Int J Neuropsychopharmacol 10:301-8. 2007
    ..Future longitudinal studies focusing on additional COMT polymorphic sites and other candidate genes from the deleted region will elucidate the molecular pathways leading to schizophrenia and other psychiatric disorders in VCFS...
  25. ncbi request reprint CAG repeat polymorphism within the KCNN3 gene is a significant contributor to susceptibility to anorexia nervosa: a case-control study of female patients and several ethnic groups in the Israeli Jewish population
    Maya Koronyo-Hamaoui
    Danek Gertner Institute of Human Genetics, Sheba Medical Center, Tel Hashomer, Israel
    Am J Med Genet B Neuropsychiatr Genet 131:76-80. 2004
    ..These findings further implicate KCNN3 as a significant contributor to predisposition to AN...
  26. ncbi request reprint COMT Val158Met polymorphism in schizophrenia with obsessive-compulsive disorder: a case-control study
    Michael Poyurovsky
    Tirat HaCarmel Mental Health Center, Tirat Carmel, Israel
    Neurosci Lett 389:21-4. 2005
    ..These results do not support the hypothesis that the COMT Val158Met gene polymorphism is associated with liability to schizophrenia-OCD...