Shai Efrati

Summary

Affiliation: Tel Aviv University
Country: Israel

Publications

  1. ncbi request reprint Optimization of endotracheal tube cuff filling by continuous upper airway carbon dioxide monitoring
    Shai Efrati
    Department of Medicine A, Assaf Harofeh Medical Center, Zerifin, 70300, Israel
    Anesth Analg 101:1081-8, table of contents. 2005
  2. ncbi request reprint N-Acetylcysteine ameliorates lithium-induced renal failure in rats
    Shai Efrati
    Department of Medicine A, Assaf Harofeh Medical Center, Zerifin, Israel
    Nephrol Dial Transplant 20:65-70. 2005
  3. doi request reprint Hyperglycaemia emerging during general anaesthesia induces rat acute kidney injury via impaired microcirculation, augmented apoptosis and inhibited cell proliferation
    Shai Efrati
    Nephrology Division, Research and Development Unit, Assaf Harofeh Medical Center, Zerifin, Israel
    Nephrology (Carlton) 17:111-22. 2012
  4. ncbi request reprint Renal functional deterioration is not affected by the magnitude of sodium consumption in a normotensive model of moderate renal failure
    Joshua Weissgarten
    Division of Nephrology, Assaf Harofeh Medical Center, Zerifin, Israel
    Am J Nephrol 25:541-7. 2005
  5. ncbi request reprint Control of hypertension with captopril affords better renal protection as compared with irbesartan in salt-loaded uremic rats
    Joshua Weissgarten
    Nephrology Division, Assaf Harofeh Medical Center, Affiliated to Sackler Faculty of Medicine, Tel Aviv University, Zerifin, Israel
    Nephron Physiol 101:p14-20. 2005
  6. doi request reprint Rosiglitazone treatment attenuates renal tissue inflammation generated by urinary tract obstruction
    Shai Efrati
    Nephrology Division, Assaf Harofeh Medical Center, Zerifin, Affiliated to Sackler Faculty of Medicine, Tel Aviv University, Israel
    Nephrology (Carlton) 14:189-97. 2009
  7. doi request reprint Hyperglycaemia, inflammation, RAS activation: three culprits to blame for acute kidney injury emerging in healthy rats during general anaesthesia
    Shai Efrati
    Nephrology Division Research and Development Unit, Assaf Harofeh Medical Center, Zerifin, Sackler Faculty of Medicine, Tel Aviv University, Israel
    Nephrology (Carlton) 17:591-602. 2012
  8. ncbi request reprint Blockade of renin-angiotensin system reduces QT dispersion and improves intracellular Ca/Mg status in hemodialysis patients
    Zhan Averbukh
    Nephrology Division, Assaf Harofeh Medical Center, Affiliated to Sackler Medical School, Tel Aviv University, Zerifin, Israel
    Nephron Clin Pract 104:c176-84. 2006
  9. doi request reprint Application of normobaric hyperoxia therapy for amelioration of haemorrhagic shock-induced acute renal failure
    Shai Efrati
    Division of Nephrology, Assaf Harofeh Medical Center, Zerifin 70300, Affiliated to Sackler Faculty of Medicine, Tel Aviv University, Israel
    Nephrol Dial Transplant 23:2213-22. 2008
  10. doi request reprint Effect of captopril treatment on recuperation from ischemia/reperfusion-induced acute renal injury
    Shai Efrati
    Research and Development Unit, Assaf Harofeh Medical Center, Zerifin 70300, Tel Aviv University, Israel
    Nephrol Dial Transplant 27:136-45. 2012

Collaborators

Detail Information

Publications38

  1. ncbi request reprint Optimization of endotracheal tube cuff filling by continuous upper airway carbon dioxide monitoring
    Shai Efrati
    Department of Medicine A, Assaf Harofeh Medical Center, Zerifin, 70300, Israel
    Anesth Analg 101:1081-8, table of contents. 2005
    ..2 +/- 3.6 versus 18.2 +/- 7.8 mm Hg, respectively; P < 0.001). According to these findings, optimal ETT cuff filling pressure can be identified by monitoring P(CO2) at the nares or the oropharynx...
  2. ncbi request reprint N-Acetylcysteine ameliorates lithium-induced renal failure in rats
    Shai Efrati
    Department of Medicine A, Assaf Harofeh Medical Center, Zerifin, Israel
    Nephrol Dial Transplant 20:65-70. 2005
    ..The purpose of this study was to examine a possible renoprotective effect of NAC against lithium-induced renal failure in a rat model...
  3. doi request reprint Hyperglycaemia emerging during general anaesthesia induces rat acute kidney injury via impaired microcirculation, augmented apoptosis and inhibited cell proliferation
    Shai Efrati
    Nephrology Division, Research and Development Unit, Assaf Harofeh Medical Center, Zerifin, Israel
    Nephrology (Carlton) 17:111-22. 2012
    ..We investigated the role of anaesthesia-triggered systemic hyperglycaemia in impairment of renal functioning, renal tissue injury, intra-renal Angiotensin-II synthesis and endogenous insulin production in anaesthetized rats...
  4. ncbi request reprint Renal functional deterioration is not affected by the magnitude of sodium consumption in a normotensive model of moderate renal failure
    Joshua Weissgarten
    Division of Nephrology, Assaf Harofeh Medical Center, Zerifin, Israel
    Am J Nephrol 25:541-7. 2005
    ..We evaluated the effects of exaggerated dietary sodium and the resultant increase in proteinuria on renal function deterioration in experimental tubulointerstitial disease in rats...
  5. ncbi request reprint Control of hypertension with captopril affords better renal protection as compared with irbesartan in salt-loaded uremic rats
    Joshua Weissgarten
    Nephrology Division, Assaf Harofeh Medical Center, Affiliated to Sackler Faculty of Medicine, Tel Aviv University, Zerifin, Israel
    Nephron Physiol 101:p14-20. 2005
    ..We investigated the effects of a high-sodium (HS) diet on the progression of renal failure in rats maintained normotensive by angiotensin-converting enzyme inhibition or AT-1 blockade...
  6. doi request reprint Rosiglitazone treatment attenuates renal tissue inflammation generated by urinary tract obstruction
    Shai Efrati
    Nephrology Division, Assaf Harofeh Medical Center, Zerifin, Affiliated to Sackler Faculty of Medicine, Tel Aviv University, Israel
    Nephrology (Carlton) 14:189-97. 2009
    ..Inflammation significantly aggravates renal injury following urinary tract obstruction. The effect of rosiglitazone on renal inflammation following unilateral ureteral obstruction was investigated...
  7. doi request reprint Hyperglycaemia, inflammation, RAS activation: three culprits to blame for acute kidney injury emerging in healthy rats during general anaesthesia
    Shai Efrati
    Nephrology Division Research and Development Unit, Assaf Harofeh Medical Center, Zerifin, Sackler Faculty of Medicine, Tel Aviv University, Israel
    Nephrology (Carlton) 17:591-602. 2012
    ..We investigated the roles of hyperglycaemia, inflammation and renin-angiotensin system (RAS) activation in induction of AKI following anaesthesia by different anaesthetic drugs and/or regimens...
  8. ncbi request reprint Blockade of renin-angiotensin system reduces QT dispersion and improves intracellular Ca/Mg status in hemodialysis patients
    Zhan Averbukh
    Nephrology Division, Assaf Harofeh Medical Center, Affiliated to Sackler Medical School, Tel Aviv University, Zerifin, Israel
    Nephron Clin Pract 104:c176-84. 2006
    ..Consequently, QT dispersion (QTd) is prolonged, correlating with high intracellular magnesium. In patients with cardiac disorders, renin-angiotensin system (RAS) inhibition reduces QTd...
  9. doi request reprint Application of normobaric hyperoxia therapy for amelioration of haemorrhagic shock-induced acute renal failure
    Shai Efrati
    Division of Nephrology, Assaf Harofeh Medical Center, Zerifin 70300, Affiliated to Sackler Faculty of Medicine, Tel Aviv University, Israel
    Nephrol Dial Transplant 23:2213-22. 2008
    ..Application of normobaric hyperoxia therapy (NHT) is an acceptable treatment for acute haemorrhagic shock. We investigated the effect of NHT on amelioration of haemorrhagic shock-induced rat renal failure...
  10. doi request reprint Effect of captopril treatment on recuperation from ischemia/reperfusion-induced acute renal injury
    Shai Efrati
    Research and Development Unit, Assaf Harofeh Medical Center, Zerifin 70300, Tel Aviv University, Israel
    Nephrol Dial Transplant 27:136-45. 2012
    ..We investigated the role of angiotensin-converting enzyme (ACE) inhibition on the progression of AKI in a rat model of ischemia/reperfusion...
  11. ncbi request reprint Hypertension but not sodium intake determines progression of renal failure in experimentally uremic rats
    Joshua Weissgarten
    Nephrology Division, Assaf Harofeh Medical Center, Zerifin, Israel
    Nephron Physiol 98:p1-7. 2004
    ..We studied the effect of high sodium consumption on progression of rat experimental renal failure while sodium-induced hypertension was pharmacologically controlled...
  12. doi request reprint Clinical variables affecting survival in patients with decompensated diastolic versus systolic heart failure
    Oleg Gorelik
    Department of Internal Medicine F, Assaf Harofeh Medical Center Affiliated to Sackler School of Medicine, Tel Aviv University, Zerifin, Israel
    Clin Res Cardiol 98:224-32. 2009
    ..The impact of various clinical variables on long-term survival of patients with acutely decompensated diastolic heart failure (DHF) compared to systolic heart failure (SHF) has not been sufficiently investigated...
  13. doi request reprint Nutritional and inflammatory status of hemodialysis patients in relation to their body mass index
    Ilia Beberashvili
    Division of Nephrology, Assaf Harofeh Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Zerifin, Israel
    J Ren Nutr 19:238-47. 2009
    ..The study tested whether obese hemodialysis (HD) patients have a better nutritional and inflammatory state than those with overweight or normal body mass index (BMI)...
  14. doi request reprint N-acetylcysteine improves residual renal function in peritoneal dialysis patients: a pilot study
    Leonid Feldman
    Nephrology Division, Assaf Harofeh Medical Center, Zerifin, Israel
    Perit Dial Int 31:545-50. 2011
    ..The aim of this study was to investigate the effect of N-acetylcysteine on peritoneal and residual renal function in peritoneal dialysis patients...
  15. doi request reprint Hyperglycemia alters renal cell responsiveness to pressure in a model of malignant hypertension
    Shai Efrati
    Research and Development Department, Assaf Harofeh Medical Center, Zerifin, Affiliated to Sackler Faculty of Medicine, Tel Aviv University, Israel
    J Hypertens 27:365-75. 2009
    ..We investigated responsiveness to pressure of various renal cell subsets subjected to hyperglycemic environment in an in-vitro model of malignant hypertension...
  16. doi request reprint Differential effects of N-acetylcysteine, theophylline or bicarbonate on contrast-induced rat renal vasoconstriction
    Shai Efrati
    Research and Development Department, Assaf Harofeh Medical Center, Zerifin, Israel
    Am J Nephrol 29:181-91. 2009
    ..We compared the effects of N-acetylcysteine (NAC), theophylline or sodium bicarbonate on intrarenal vasoconstriction and ROS generation in a rat model of CM-induced nephropathy...
  17. ncbi request reprint N-acetylcysteine ameliorates amphotericin-induced nephropathy in rats
    Leonid Feldman
    Nephrology Division, Assaf Harofeh Medical Center Affiliated to Sackler Faculty of Medicine, Tel Aviv University, Zerifin, Israel
    Nephron Physiol 99:p23-7. 2005
    ..Amphotericin B may cause acute reduction in renal function. N-acetylcysteine (NAC) has a renoprotective activity in several nephrotoxic renal insults, but its effect on amphotericin-induced renal failure has not been investigated yet...
  18. ncbi request reprint Apoptosis and proliferation of mesangial cells isolated from kidneys undergoing compensatory growth following contralateral nephrectomy: role of the renin-angiotensin system
    Joshua Weissgarten
    Nephrology Division, Assaf Harofeh Medical Center, Affiliated to Sackler Faculty of Medicine, Tel Aviv University, Israel
    Med Sci Monit 13:BR16-23. 2007
    ..The proliferation and apoptosis of cultured rat mesangial cells isolated from the remaining kidney following contralateral nephrectomy were evaluated. The involvement of the renin-angiotensin system was concomitantly assessed...
  19. doi request reprint The effect of sitagliptin versus glibenclamide on arterial stiffness, blood pressure, lipids, and inflammation in type 2 diabetes mellitus patients
    Shlomit Koren
    Department of Internal Medicine A, Assaf Harofeh Medical Center, Zerifin, Israel
    Diabetes Technol Ther 14:561-7. 2012
    ..This study evaluated the effect of sitagliptin versus glibenclamide on arterial stiffness, blood pressure, lipid profile, oxidative stress, and high-sensitivity C-reactive protein (hsCRP) in type 2 diabetes mellitus patients...
  20. ncbi request reprint Enhanced angiotensin II production by renal mesangium is responsible for apoptosis/proliferation of endothelial and epithelial cells in a model of malignant hypertension
    Shai Efrati
    Division of Nephrology, Assaf Harofeh Medical Center, Zerifin, Israel
    J Hypertens 25:1041-52. 2007
    ..However, the intrarenal RAS might be at least equally important. We investigated the relationship between intrarenal RAS and mesangial, epithelial and endothelial cell proliferation/apoptosis in a model of malignant hypertension...
  21. ncbi request reprint Apoptosis and proliferation of cultured mesangial cells isolated from kidneys of rosiglitazone-treated pregnant diabetic rats
    Joshua Weissgarten
    Nephrology Division, Assaf Harofeh Medical Center, Zerifin 70300, Israel
    Nephrol Dial Transplant 21:1198-204. 2006
    ....
  22. ncbi request reprint N-acetylcysteine attenuates NSAID-induced rat renal failure by restoring intrarenal prostaglandin synthesis
    Shai Efrati
    Nephrology Division, Research and Development Unit, Department of Internal Medicine A, Assaf Harofeh Medical Center, Zerifin 70300, and Sackler Faculty of Medicine, Tel Aviv University, Israel
    Nephrol Dial Transplant 22:1873-81. 2007
    ..N-acetylcysteine (NAC) has renoprotective properties. We examined effects of NAC in a rat model of NSAID-induced renal failure...
  23. ncbi request reprint PPAR-gamma activation inhibits angiotensin II synthesis, apoptosis, and proliferation of mesangial cells from spontaneously hypertensive rats
    Shai Efrati
    Nephrology Division, Department of Nephrology, Assaf Harofeh Medical Center, Zerifin, Israel
    Nephron Exp Nephrol 106:e107-12. 2007
    ....
  24. ncbi request reprint Rosiglitazone treatment attenuates expression of inflammatory hallmarks in the remaining kidney following contralateral nephrectomy
    Shai Efrati
    Nephrology Division, Assaf Harofeh Medical Center, Affiliated to Sackler Faculty of Medicine, Tel Aviv University, Zerifin, Israel
    Am J Nephrol 28:238-45. 2008
    ..We applied rosiglitazone to attenuate inflammatory processes ongoing within the remaining kidney following contralateral nephrectomy...
  25. doi request reprint N-3 fatty acid supplementation to routine statin treatment inhibits platelet function, decreases patients' daytime blood pressure, and improves inflammatory status
    Keren Doenyas-Barak
    Research and Development Unit and Nephrology Division, Assaf Harofeh Medical Center, Tel Aviv University, Zerifin 70300, Israel
    Eur J Clin Pharmacol 68:1139-46. 2012
    ..Administration of N-3 fatty acids to patients treated with statins may potentiate the treatment effects. We examined the operating mechanisms underlying such a combination...
  26. ncbi request reprint The effect of N-acetylcysteine on renal function, nitric oxide, and oxidative stress after angiography
    Shai Efrati
    Department of Medicine A, Division of Cardiology, Asaf Harofeh Medical Center, Zerifin, Israel
    Kidney Int 64:2182-7. 2003
    ..We examined the hypothesis that NAC protected against contrast-induced renal impairment through effects on nitric oxide metabolism and oxidative stress...
  27. ncbi request reprint Serious consequences to the use of cephalosporins as the first line of antimicrobial therapy administered in hemodialysis units
    Dror Marchaim
    Department of Medicine A, Asaf Harofe Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Zerifin, Israel
    Nephron Clin Pract 101:c58-64. 2005
    ..The aim of the study was to examine the effects of this new regimen on the colonization rate of resistant bacteria among HD patients...
  28. ncbi request reprint Effect of various clinical variables on total intracellular magnesium in hospitalized normomagnesemic diabetic patients before discharge
    Oleg Gorelik
    Department of Internal Medicine F, Assaf Harofeh Medical Center, Sackler School of Medicine, Tel Aviv University, Ramat Aviv, Zerifin 70300, Israel
    Biol Trace Elem Res 120:102-9. 2007
    ..In conclusion, icMg is depleted in normomagnesemic DM patients. Insulin treatment is associated with worsening of icMg status, while metformin treatment may confer protective effect...
  29. ncbi request reprint Cell-associated magnesium and QT dispersion in hemodialysis patients
    Zhan Averbukh
    Nephrology Division and Department of Medicine F, Assaf Harofeh Medical Center, Zerifin, Israel
    Am J Kidney Dis 41:196-202. 2003
    ..Cardiac arrhythmias are common in patients on hemodialysis therapy...
  30. doi request reprint The effect of levothyroxine on arterial stiffness and lipid profile in patients with subclinical hypothyroidism
    Ronit Koren Peleg
    Department of Internal Medicine A, Assaf Harofeh Medical Center, Zerifin, Israel
    Thyroid 18:825-30. 2008
    ..The aim of this study was to evaluate the effect of levothyroxine on arterial stiffness, lipid profile, and inflammation...
  31. ncbi request reprint ACE inhibitors and survival of hemodialysis patients
    Shai Efrati
    Department of Internal Medicine A, Assaf Harofeh Medical Center, Zerifin, Israel
    Am J Kidney Dis 40:1023-9. 2002
    ..We investigated their effect on mortality in patients undergoing long-term hemodialysis therapy...
  32. doi request reprint Mesangial cells are responsible for orchestrating the renal podocytes injury in the context of malignant hypertension
    Sylvia Berman
    Research and Development Unit, Assaf Harofeh Medical Center, Zerifin, Israel
    Nephrology (Carlton) 18:292-8. 2013
    ..The role of podocytes in pathogenesis of malignant hypertension is unclear. We investigated responsiveness of normal vs. hyperglycaemic podocytes to pressure in a model of malignant hypertension...
  33. doi request reprint Endotracheal tube cuff--small important part of a big issue
    Shai Efrati
    Research and Development Unit, Assaf Harofeh Medical Center, 70300, Zerifin, Israel
    J Clin Monit Comput 26:53-60. 2012
    ..The article challenges the present paradigm of cuff use and reviews the current clinical practice in that area...
  34. doi request reprint Ventilator-associated pneumonia: current status and future recommendations
    Shai Efrati
    Research and Development Unit, Assaf Harofeh Medical Center, affiliated with the Sackler School of Medicine, Tel Aviv University, Zerifin, 70300, Israel
    J Clin Monit Comput 24:161-8. 2010
    ..Ventilator-associated pneumonia (VAP) is a common hazardous complication in ICU patients. The aim of the current review is to give an update on the current status and future recommendations for VAP prevention...
  35. doi request reprint Tracheal pressure and endotracheal tube obstruction can be detected by continuous cuff pressure monitoring: in vitro pilot study
    Shai Efrati
    Research and Development Unit, Assaf Harofeh Medical Center, Zerifin, Sackler School of Medicine, Tel Aviv University, Zerifin, Israel
    Intensive Care Med 36:984-90. 2010
    ..To evaluate whether the degree of endotracheal tube (ETT) obstruction can be predicted by changes of ETT cuff pressure (P (c)) as a function of peak inspiratory pressure...
  36. doi request reprint Application of muscle biopotential measurement for sustained, noninvasive blood glucose survey
    Alexander Vol
    Research and Development Unit, Assaf Harofeh Medical Center, Zerifin, Affiliated to Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    J Appl Physiol 107:253-60. 2009
    ..Biopotential measurements may be used for continuous, noninvasive estimation of changes in BGC. Further studies are needed to evaluate the applicability of this method to humans...
  37. ncbi request reprint Early onset of hyperkalemia in patients treated with low molecular weight heparin: a prospective study
    Maya Koren-Michowitz
    Department of Medicine A, Assaf Harofe Medical Center, Zerifin, Israel
    Pharmacoepidemiol Drug Saf 13:299-302. 2004
    ..Data on low molecular weight heparin (LMWH) and induction of hyperkalemia is scarce. Therefore, we conducted a prospective study evaluating potassium levels before and after three days of treatment with the LMWH Enoxaparin...
  38. ncbi request reprint Improved regional left ventricular function after successful satellite cell grafting in rabbits with myocardial infarction
    Alex Blatt
    Cardiology Department, Assaf Harofeh Medical Center, Zerifin 70300, Israel
    Eur J Heart Fail 5:751-7. 2003
    ..To evaluate whether satellite cells injected into infarct areas in rabbits remain viable during 6 weeks follow-up and can improve cardiac function as assessed by echocardiography...