Ari Barzilai

Summary

Affiliation: Tel Aviv University
Country: Israel

Publications

  1. ncbi request reprint Accumulation of DNA damage and reduced levels of nicotine adenine dinucleotide in the brains of Atm-deficient mice
    Nora Stern
    Department of Neurobiochemistry, George S Wise Faculty of Life Sciences, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel
    J Biol Chem 277:602-8. 2002
  2. ncbi request reprint The contribution of the DNA damage response to neuronal viability
    Ari Barzilai
    Department of Neurobiochemistry, George S Wise Faculty of Life Sciences, Tel Aviv University, Israel
    Antioxid Redox Signal 9:211-8. 2007
  3. ncbi request reprint The molecular mechanism of dopamine-induced apoptosis: identification and characterization of genes that mediate dopamine toxicity
    A Barzilai
    Department of Neurobiochemistry, George S Wise Faculty of Life Sciences, Tel Aviv University, Israel
    J Neural Transm Suppl . 2000
  4. doi request reprint The role of the DNA damage response in neuronal development, organization and maintenance
    Ari Barzilai
    Department of Neurobiology, George S Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv 69978, Israel
    DNA Repair (Amst) 7:1010-27. 2008
  5. ncbi request reprint Molecular mechanisms of selective dopaminergic neuronal death in Parkinson's disease
    Ari Barzilai
    Dept of Neurobiochemistry, George S Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv 69978, Israel
    Trends Mol Med 9:126-32. 2003
  6. doi request reprint DNA damage, neuronal and glial cell death and neurodegeneration
    Ari Barzilai
    Department of Neurobiology, George S Wise Faculty of Life Sciences, Tel Aviv University, 69978 Tel Aviv, Israel
    Apoptosis 15:1371-81. 2010
  7. ncbi request reprint Is there a rationale for neuroprotection against dopamine toxicity in Parkinson's disease?
    A Barzilai
    Department of Neurobiochemistry, George S Wise Faculty of Life Sciences, Tel Aviv University, Israel
    Cell Mol Neurobiol 21:215-35. 2001
  8. doi request reprint The neuro-glial-vascular interrelations in genomic instability symptoms
    Ari Barzilai
    Department of Neurobiology, George S Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv 69978, Israel
    Mech Ageing Dev 132:395-404. 2011
  9. doi request reprint Analysis of the relationships between ATM and the Rad54 paralogs involved in homologous recombination repair
    Michal Kirshner
    Department of Neurobiology, George S Wise, Faculty of Life Sciences, Tel Aviv University, Tel Aviv 69978, Israel
    DNA Repair (Amst) 8:253-61. 2009
  10. pmc Investigation of the functional link between ATM and NBS1 in the DNA damage response in the mouse cerebellum
    Inbal Dar
    Department of Neurobiology, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel
    J Biol Chem 286:15361-76. 2011

Collaborators

Detail Information

Publications48

  1. ncbi request reprint Accumulation of DNA damage and reduced levels of nicotine adenine dinucleotide in the brains of Atm-deficient mice
    Nora Stern
    Department of Neurobiochemistry, George S Wise Faculty of Life Sciences, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel
    J Biol Chem 277:602-8. 2002
    ..Taken together, our findings support the hypothesis that absence of functional ATM results in continuous stress, which may be an important cause of the degeneration of cerebellar neurons in A-T...
  2. ncbi request reprint The contribution of the DNA damage response to neuronal viability
    Ari Barzilai
    Department of Neurobiochemistry, George S Wise Faculty of Life Sciences, Tel Aviv University, Israel
    Antioxid Redox Signal 9:211-8. 2007
    ..Defective DNA damage response in older human age can generate neurodegenerative disorders such as Alzheimer's or Parkinson diseases...
  3. ncbi request reprint The molecular mechanism of dopamine-induced apoptosis: identification and characterization of genes that mediate dopamine toxicity
    A Barzilai
    Department of Neurobiochemistry, George S Wise Faculty of Life Sciences, Tel Aviv University, Israel
    J Neural Transm Suppl . 2000
    ..These findings suggest a functional role for collapsin-1 and TCP-1delta as positive mediators of DA-induced neuronal apoptosis...
  4. doi request reprint The role of the DNA damage response in neuronal development, organization and maintenance
    Ari Barzilai
    Department of Neurobiology, George S Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv 69978, Israel
    DNA Repair (Amst) 7:1010-27. 2008
    ..This review focuses on the DNA damage response in neuronal cells and points to the importance of this elaborate network to the integrity of the nervous system from its early development and throughout the lifetime of the organism...
  5. ncbi request reprint Molecular mechanisms of selective dopaminergic neuronal death in Parkinson's disease
    Ari Barzilai
    Dept of Neurobiochemistry, George S Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv 69978, Israel
    Trends Mol Med 9:126-32. 2003
    ..These factors, and the interactions among them, might hold the secret to the underlying causes of the selective death of dopaminergic neurons in PD...
  6. doi request reprint DNA damage, neuronal and glial cell death and neurodegeneration
    Ari Barzilai
    Department of Neurobiology, George S Wise Faculty of Life Sciences, Tel Aviv University, 69978 Tel Aviv, Israel
    Apoptosis 15:1371-81. 2010
    ....
  7. ncbi request reprint Is there a rationale for neuroprotection against dopamine toxicity in Parkinson's disease?
    A Barzilai
    Department of Neurobiochemistry, George S Wise Faculty of Life Sciences, Tel Aviv University, Israel
    Cell Mol Neurobiol 21:215-35. 2001
    ..The signal transduction pathways and genes, which are associated with DA toxicity are described in detail...
  8. doi request reprint The neuro-glial-vascular interrelations in genomic instability symptoms
    Ari Barzilai
    Department of Neurobiology, George S Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv 69978, Israel
    Mech Ageing Dev 132:395-404. 2011
    ..Here I describe various aspects of neural and glial cell fate and the vascular system in genomic instability disorders including ataxia telangiectasia (A-T) and Nijmegen breakage syndrome...
  9. doi request reprint Analysis of the relationships between ATM and the Rad54 paralogs involved in homologous recombination repair
    Michal Kirshner
    Department of Neurobiology, George S Wise, Faculty of Life Sciences, Tel Aviv University, Tel Aviv 69978, Israel
    DNA Repair (Amst) 8:253-61. 2009
    ..Our results reveal a differential interaction of the ATM-mediated DNA damage response and Rad54 paralog-mediated HR depending on the DNA damaging agent that initiates the response...
  10. pmc Investigation of the functional link between ATM and NBS1 in the DNA damage response in the mouse cerebellum
    Inbal Dar
    Department of Neurobiology, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel
    J Biol Chem 286:15361-76. 2011
    ..Combined loss of Nbs1 and Atm in the CNS significantly abrogated the DSB response compared with the single mutation genotypes. Importantly, the data indicate that Atm has cellular roles not regulated by Nbs1 in the murine cerebellum...
  11. ncbi request reprint Analysis of the ataxia telangiectasia mutated-mediated DNA damage response in murine cerebellar neurons
    Inbal Dar
    Department of Neurobiochemistry, George S Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv 69978, Israel
    J Neurosci 26:7767-74. 2006
    ..These results support the notion that the cerebellar degeneration in A-T patients results from defective DNA damage response...
  12. doi request reprint Conditional inactivation of the NBS1 gene in the mouse central nervous system leads to neurodegeneration and disorganization of the visual system
    Koby Baranes
    Department of Neurobiology, George S Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, 69978 Israel
    Exp Neurol 218:24-32. 2009
    ..Electroretinogram analysis revealed marked reduction in a- and b-waves, indicative of decreased retinal function. Our study points to a novel role for Nbs1 in the development, organization and function of the visual system...
  13. doi request reprint The neurological phenotype of ataxia-telangiectasia: solving a persistent puzzle
    Sharon Biton
    Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel
    DNA Repair (Amst) 7:1028-38. 2008
    ..A-T remains a prototype disease for the study of the DDR's role in CNS development and maintenance...
  14. ncbi request reprint Nuclear ataxia-telangiectasia mutated (ATM) mediates the cellular response to DNA double strand breaks in human neuron-like cells
    Sharon Biton
    The David and Inez Myers Laboratory for Genetic Research, Department of Molecular Genetics and Biochemistry, Tel Aviv University, Tel Aviv 69978, Israel
    J Biol Chem 281:17482-91. 2006
    ..We concluded that nuclear ATM mediates the DSB response in NLCs similarly to in proliferating cells. Attempts to understand the neurodegeneration in A-T should be directed to investigating the DSB response in the nervous system...
  15. doi request reprint Sema-3A indirectly disrupts the regeneration process of goldfish optic nerve after controlled injury
    Shira Rosenzweig
    Departments of Neurobiology, George S Wise, Faculty of Life Sciences, Tel Aviv University, Tel Aviv, 69978, Israel
    Graefes Arch Clin Exp Ophthalmol 248:1423-35. 2010
    ..Semaphorin-3A (sema-3A), a member of the class 3 semaphorins known for its repellent and apoptotic activities, has previously been shown to play a key role in the formation of a non-permissive environment after CNS injury in mammalians...
  16. ncbi request reprint Contribution of the Atm protein to maintaining cellular homeostasis evidenced by continuous activation of the AP-1 pathway in Atm-deficient brains
    Nir Weizman
    Department of Neurobiochemistry, George S Wise Faculty of Life Sciences, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978 Israel
    J Biol Chem 278:6741-7. 2003
    ..Our results further demonstrate that inactivation of the ATM gene results in a state of constant stress...
  17. doi request reprint Malfunctioning DNA damage response (DDR) leads to the degeneration of nigro-striatal pathway in mouse brain
    Michal Kirshner
    Department of Neurobiology, George S Wise, Faculty of Life Sciences, Tel Aviv University, Tel Aviv, 69978, Israel
    J Mol Neurosci 46:554-68. 2012
    ..These results indicate that malfunctioning DNA damage response severely affects the integrity of the nigro-striatal pathway and suggest a new neurodegenerative pathway in Parkinsonian syndromes...
  18. doi request reprint Astrocyte dysfunction associated with cerebellar attrition in a Nijmegen breakage syndrome animal model
    Ronit Galron
    Department of Neurobiology, George S Wise, Faculty of Life Sciences, Tel Aviv University, Tel Aviv 69978, Israel
    J Mol Neurosci 45:202-11. 2011
    ..Understanding the contribution of malfunctioning astrocytes to the etiology of NBS can elucidate a hitherto unknown aspect of this disorder...
  19. doi request reprint Upregulation of Semaphorin 3A and the associated biochemical and cellular events in a rat model of retinal detachment
    Olga Klebanov
    Goldschleger Eye Research Institute, Faculty of Medicine, Tel Aviv University, Haim Sheba Medical Center, Tel Hashomer, Israel
    Graefes Arch Clin Exp Ophthalmol 247:73-86. 2009
    ..Despite advanced surgical repair techniques, the visual acuity of patients is often limited. We investigated some of the biochemical and morphological alterations following experimental retinal detachment in laboratory animals...
  20. ncbi request reprint ATM deficiency and oxidative stress: a new dimension of defective response to DNA damage
    Ari Barzilai
    Department of Neurobiochemistry, George S Wise Faculty of Life Sciences, Tel Aviv University, 69978, Tel Aviv, Israel
    DNA Repair (Amst) 1:3-25. 2002
    ..This connection may provide new insights into the phenotypes associated with genetic deficiencies of DNA damage responses, and point to new strategies to alleviate some of their clinical symptoms...
  21. doi request reprint The interrelations between malfunctioning DNA damage response (DDR) and the functionality of the neuro-glio-vascular unit
    Ari Barzilai
    Department of Neurobiology, George S Wise Faculty of Life Sciences and Sagol School of Neuroscience, Tel Aviv University, Tel Aviv 69978, Israel
    DNA Repair (Amst) 12:543-57. 2013
    ..These events lead to systematic neural cell death on a scale that appears to be proportional to the severity of the neurological deficit. ..
  22. pmc A role for vascular deficiency in retinal pathology in a mouse model of ataxia-telangiectasia
    Dorit Raz-Prag
    Department of Neurobiology, George S Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel
    Am J Pathol 179:1533-41. 2011
    ....
  23. ncbi request reprint Impaired genomic stability and increased oxidative stress exacerbate different features of Ataxia-telangiectasia
    Shelly Ziv
    Department of Neurobiochemistry, George S Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv 69978, Israel
    Hum Mol Genet 14:2929-43. 2005
    ....
  24. ncbi request reprint The molecular mechanisms of dopamine toxicity
    Ari Barzilai
    Department of Neurobiochemistry, George S Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel
    Adv Neurol 91:73-82. 2003
  25. doi request reprint Studying the cerebellar DNA damage response in the tissue culture dish
    Aya Tzur-Gilat
    The David and Inez Myers Laboratory for Cancer Genetics, Department of Human Molecular Genetics and Biochemistry, Tel Aviv 69978, Israel
    Mech Ageing Dev 134:496-505. 2013
    ..Our results to date, which indicate special chromatin organization in Purkinje cells that affects certain pathways of the DDR, demonstrate the usefulness of cerebellar organotypic cultures for addressing the above questions. ..
  26. ncbi request reprint MRI evidence of white matter damage in a mouse model of Nijmegen breakage syndrome
    Yaniv Assaf
    Department of Neurobiochemistry, George S Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel
    Exp Neurol 209:181-91. 2008
    ..Myelin index and protein levels were significantly reduced in these brains. Our results point to a novel function of Nbs1 in the development and organization of the white matter...
  27. ncbi request reprint DNA damage responses to oxidative stress
    Ari Barzilai
    Department of Neurobiochemistry, George S Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv 69978, Israel
    DNA Repair (Amst) 3:1109-15. 2004
    ..To allow time for DNA repair, the cells activate their cell cycle checkpoints, leading to cell cycle arrest and preventing the replication of damage and defective DNA...
  28. ncbi request reprint Effect of lipoteichoic acid on the uptake of Streptococcus pyogenes by HEp-2 cells
    S Sela
    Department of Human Microbiology, Sackler School of Medicine, Tel Aviv University, Ramat Aviv, Israel
    FEMS Microbiol Lett 193:187-93. 2000
    ..A possible target for LTA activity might be the actin cytoskeleton, which is known to be essential for bacterial uptake...
  29. ncbi request reprint UVB therapy of pityriasis lichenoides--our experience with 29 patients
    F Pavlotsky
    Phototherapy Unit, Department of Dermatology, Sheba Medical Center, Tel Hashomer and Sackler School of Medicine, Tel Aviv University, Israel
    J Eur Acad Dermatol Venereol 20:542-7. 2006
    ..Pityriasis lichenoides comprises a clinical and pathological spectrum of disorders. So far no highly effective treatment has been reported. Previous small studies have suggested that ultraviolet B (UVB) is a good alternative...
  30. ncbi request reprint UVB in the management of early stage mycosis fungoides
    F Pavlotsky
    Phototherapy Unit, Department of Dermatology, Sheba Medical Center, Tel Hashomer, Israel
    J Eur Acad Dermatol Venereol 20:565-72. 2006
    ..Several options for treatment of early mycosis fungoides (MF) offer similar success rates. Previous small studies have shown UVB to be at least as effective as PUVA...
  31. ncbi request reprint Relationship between asymptomatic carriage of Streptococcus pyogenes and the ability of the strains to adhere to and be internalised by cultured epithelial cells
    S Sela
    Department of Human Microbiology, Sackler School of Medicine, Tel Aviv University, Israel
    J Med Microbiol 49:499-502. 2000
    ..4 (SE 1.6)% in the control group. The results are in agreement with the hypothesis that, in a significant number of cases, streptococcal internalisation might contribute to eradication failure and persistent throat carriage...
  32. ncbi request reprint Acute respiratory distress syndrome in children: a 10 year experience
    G Paret
    Department of Pediatric Intensive Care, Sheba Medical Center, Tel Hashomer, Israel
    Isr Med Assoc J 1:149-53. 1999
    ..Acute respiratory distress syndrome is a well-recognized condition resulting in high permeability pulmonary edema associated with a high morbidity...
  33. ncbi request reprint Insect bite-like reaction in patients with hematologic malignant neoplasms
    A Barzilai
    Department of Dermatology, Sheba Medical Center, Tel Hashomer, Israel
    Arch Dermatol 135:1503-7. 1999
    ..Skin lesions usually appear months to years after the diagnosis of leukemia and are unrelated to laboratory findings, disease course, or therapy...
  34. ncbi request reprint Ventilation index and outcome in children with acute respiratory distress syndrome
    G Paret
    Pediatric Intensive Care Unit, The Chaim Sheba Medical Center, Tel Hashomer, Israel
    Pediatr Pulmonol 26:125-8. 1998
    ..We conclude that the VI provides a reliable prognostic marker in children with ARDS, and its increase above 65 indicates a need for orderly intervention with alternative modalities of care...
  35. doi request reprint Astrocytes from old Alzheimer's disease mice are impaired in Aβ uptake and in neuroprotection
    Tal Iram
    Department of Neurobiology, George S Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel
    Neurobiol Dis 96:84-94. 2016
    ..Further understanding of the impact of astrocyte impairment on AD pathology may provide insights into the etiology of AD...
  36. doi request reprint Genome instability: Linking ageing and brain degeneration
    Ari Barzilai
    Department of Neurobiology, George S Wise, Faculty of Life Sciences, Sagol School of Neuroscience, Israel
    Mech Ageing Dev . 2016
    ..This review discusses these similarities and differences and highlights cell classes whose role in these processes might have been underestimated-glia and microglia...
  37. pmc Connecting Malfunctioning Glial Cells and Brain Degenerative Disorders
    Natalie Kaminsky
    Department of Neurobiology, George S Wise, Faculty of Life Sciences, Tel Aviv University, Tel Aviv 6997801, Israel
    Genomics Proteomics Bioinformatics 14:155-65. 2016
    ..These events can lead to systematic neural demise on a scale that appears to be proportional to the severity of the neurological deficit. ..
  38. ncbi request reprint The role of IVIg treatment in severe pemphigus vulgaris
    S Baum
    Department of Dermatology, Sheba Medical Center, affiliated with the Sackler Faculty of Medicine, Tel Aviv University, Israel
    J Eur Acad Dermatol Venereol 20:548-52. 2006
    ..Some consider IVIg as an adjuvant steroid sparing agent in PV, while others as disease modifying that can be used as monotherapy...
  39. ncbi request reprint Predictors of adverse outcome from candidal infection in a tertiary care hospital
    R Ben-Abraham
    Department of Anesthesiology and Critical Care, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    J Infect 49:317-23. 2004
    ..To retrospectively delineate predictors of adverse outcome by looking at the demographic features, therapy and outcome of systemic candida infection in a large tertiary care university-affiliated medical center...
  40. ncbi request reprint Glutaredoxin protects cerebellar granule neurons from dopamine-induced apoptosis by dual activation of the ras-phosphoinositide 3-kinase and jun n-terminal kinase pathways
    D Daily
    Department of Neurobiochemistry, George S. Wise Faculty of Life Sciences, Tel Aviv University, Ramat Aviv, Tel Aviv 69978, Israel
    J Biol Chem 276:21618-26. 2001
    ..These results demonstrate that dual activation of Ras/phosphoinositide 3-kinase and AP-1 cascades, which are mediated by Ref-1, is an essential component of the Grx2 mechanism of action...
  41. ncbi request reprint Increased oxidative stress in ataxia telangiectasia evidenced by alterations in redox state of brains from Atm-deficient mice
    A Kamsler
    Department of Neurobiochemistry, George S. Wise Faculty of Life Sciences, Tel Aviv University, Israel
    Cancer Res 61:1849-54. 2001
    ..Our findings support the hypothesis that the absence of functional ATM results in oxidative stress, which may be an important cause of the degeneration of cerebellar neurons in A-T...
  42. ncbi request reprint Glutaredoxin protects cerebellar granule neurons from dopamine-induced apoptosis by activating NF-kappa B via Ref-1
    D Daily
    Department of Neurobiochemistry, George S. Wise Faculty of Life Sciences, Tel Aviv University, Ramat Aviv, Tel Aviv 69978 Israel
    J Biol Chem 276:1335-44. 2001
    ..These results show that Grx2 exerts its anti apoptotic activity through the activation of Ref-1, which then activates NF-kappaB...
  43. ncbi request reprint Involvement of T-complex protein-1delta in dopamine triggered apoptosis in chick embryo sympathetic neurons
    R Zilkha-Falb
    Department of Neurobiochemistry, George S Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv 69978, Israel
    J Biol Chem 275:36380-7. 2000
    ..These findings suggest a functional role for TCP-1delta as a positive mediator of DA-induced neuronal apoptosis...
  44. ncbi request reprint The susceptibility of Streptococcus pneumoniae to levofloxacin and other antibiotics
    N Keller
    Chaim Sheba Medical Centre, Tel Aviv University, School of Medicine, Tel Hashomer, Israel
    J Antimicrob Chemother 43:1-3. 1999
    ..We conclude that all S. pneumoniae isolates tested were susceptible to levofloxacin, ofloxacin and sparfloxacin. However, about 85% were susceptible to amoxycillin and the other beta-lactam antibiotics tested...
  45. ncbi request reprint CuZn-SOD deficiency, rather than overexpression, is associated with enhanced recovery and attenuated activation of NF-kappaB after brain trauma in mice
    Sara M Beni
    Department of Pharmacology, School of Pharmacy, The Hebrew University of Jerusalem, Jerusalem, Israel
    J Cereb Blood Flow Metab 26:478-90. 2006
    ..We suggest that SOD1 deficiency impairs H2O2-mediated activation of NF-kappaB, decreasing death-promoting signals, and leading to better outcome...
  46. ncbi request reprint Up-regulation of semaphorin expression in retina of glaucomatous rabbits
    Arieh S Solomon
    Goldchleger Eye Research Institute, Chaim Sheba Medical Center, Tel Hashomer, Israel
    Graefes Arch Clin Exp Ophthalmol 241:673-81. 2003
    ..The purpose of this study was to analyze the effect of increased IOP on RGC viability and to analyze semaphorin expression pattern in glaucomatous retinas...
  47. ncbi request reprint Mammalian meiosis involves DNA double-strand breaks with 3' overhangs
    Drora Zenvirth
    Department of Genetics, The Hebrew University, Jerusalem 91904, Israel
    Chromosoma 111:369-76. 2003
    ..Thus the processing of DSBs into 3' overhangs is common to meiotic cells in mammals and yeast, and probably in all eukaryotes...
  48. ncbi request reprint Anti-semaphorin 3A antibodies rescue retinal ganglion cells from cell death following optic nerve axotomy
    Anat Shirvan
    Department of Neurology and the Felsenstein Medical Research Center, Rabin Medical Center, Beilinson Campus, and the Sackler School of Medicine, Petach Tiqva 49100, Israel
    J Biol Chem 277:49799-807. 2002
    ....