Y Assaf

Summary

Affiliation: Tel Aviv University
Country: Israel

Publications

  1. ncbi request reprint White matter changes in multiple sclerosis: correlation of q-space diffusion MRI and 1H MRS
    Yaniv Assaf
    Functional Brain Imaging Laboratory, Tel Aviv Sourasky Medical Center, Tel Aviv 64239, Israel
    Magn Reson Imaging 23:703-10. 2005
  2. ncbi request reprint Diffusion tensor imaging (DTI)-based white matter mapping in brain research: a review
    Yaniv Assaf
    Department of Neurobiochemistry, Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel
    J Mol Neurosci 34:51-61. 2008
  3. pmc Diffusion MRI of structural brain plasticity induced by a learning and memory task
    Tamar Blumenfeld-Katzir
    Department of Neurobiology, The George S Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel
    PLoS ONE 6:e20678. 2011
  4. ncbi request reprint High b value q-space-analyzed diffusion MRI in vascular dementia: a preliminary study
    Y Assaf
    Wohl Institute for Advanced Imaging, Tel Aviv Sourasky Medical Center, Tel Aviv 64239, Israel
    J Neurol Sci 203:235-9. 2002
  5. ncbi request reprint Characterization of displaced white matter by brain tumors using combined DTI and fMRI
    Tom Schonberg
    Department of Psychology, Tel Aviv University, Tel Aviv, Israel
    Neuroimage 30:1100-11. 2006
  6. ncbi request reprint New modeling and experimental framework to characterize hindered and restricted water diffusion in brain white matter
    Yaniv Assaf
    Functional Brain Imaging Unit, The Wohl Institute for Advanced Imaging, Tel Aviv Sourasky Medical Center, Israel
    Magn Reson Med 52:965-78. 2004
  7. ncbi request reprint High b-value q-space analyzed diffusion-weighted MRI: application to multiple sclerosis
    Y Assaf
    School of Chemistry, Raymond and Beverly Sackler Faculty of Exact Sciences, Tel Aviv University, Ramat Aviv, Tel Aviv, Israel
    Magn Reson Med 47:115-26. 2002
  8. ncbi request reprint The effect of rotational angle and experimental parameters on the diffraction patterns and micro-structural information obtained from q-space diffusion NMR: implication for diffusion in white matter fibers
    Liat Avram
    School of Chemistry, The Sackler Faculty of Exact Sciences, Tel Aviv University, Ramat Aviv, Tel Aviv 69978, Israel
    J Magn Reson 169:30-8. 2004
  9. doi request reprint Combinatorial fiber-tracking of the human brain
    Shlomi Lifshits
    Department of Neurobiology, Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel
    Neuroimage 48:532-40. 2009
  10. ncbi request reprint High b-value diffusion imaging of dementia: application to vascular dementia and alzheimer disease
    Orna Mayzel-Oreg
    School of Chemistry, The Sackler Faulty of Exact Sciences, Tel Aviv University, Ramat Aviv, Tel Aviv 69978, Israel
    J Neurol Sci 257:105-13. 2007

Collaborators

Detail Information

Publications39

  1. ncbi request reprint White matter changes in multiple sclerosis: correlation of q-space diffusion MRI and 1H MRS
    Yaniv Assaf
    Functional Brain Imaging Laboratory, Tel Aviv Sourasky Medical Center, Tel Aviv 64239, Israel
    Magn Reson Imaging 23:703-10. 2005
    ..More specifically, we aimed at evaluating the ability of this methodology to identify tissue damage in the so-called normal-appearing white matter (NAWM)...
  2. ncbi request reprint Diffusion tensor imaging (DTI)-based white matter mapping in brain research: a review
    Yaniv Assaf
    Department of Neurobiochemistry, Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel
    J Mol Neurosci 34:51-61. 2008
    ..This review summarizes the development of DTI in the last decade with respect to the specificity and utility of the technique in radiology and anatomy studies...
  3. pmc Diffusion MRI of structural brain plasticity induced by a learning and memory task
    Tamar Blumenfeld-Katzir
    Department of Neurobiology, The George S Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel
    PLoS ONE 6:e20678. 2011
    ..Although T1 and diffusion MRI have been used to study structural changes resulting from long-term training, the cellular basis of the findings obtained and their relationship to neuroplasticity are poorly understood...
  4. ncbi request reprint High b value q-space-analyzed diffusion MRI in vascular dementia: a preliminary study
    Y Assaf
    Wohl Institute for Advanced Imaging, Tel Aviv Sourasky Medical Center, Tel Aviv 64239, Israel
    J Neurol Sci 203:235-9. 2002
    ..This technique, therefore, might serve as a better indication for the extensive nerve fiber loss in the white matter that is caused by vascular disease...
  5. ncbi request reprint Characterization of displaced white matter by brain tumors using combined DTI and fMRI
    Tom Schonberg
    Department of Psychology, Tel Aviv University, Tel Aviv, Israel
    Neuroimage 30:1100-11. 2006
    ..With fMRI, one can more accurately define the seed ROI for DTI based tractography and to provide a more comprehensive, functionally related, white matter mapping, a very important tool used in pre-surgical mapping...
  6. ncbi request reprint New modeling and experimental framework to characterize hindered and restricted water diffusion in brain white matter
    Yaniv Assaf
    Functional Brain Imaging Unit, The Wohl Institute for Advanced Imaging, Tel Aviv Sourasky Medical Center, Israel
    Magn Reson Med 52:965-78. 2004
    ..This framework shows promise in determining the orientations of two or more fiber compartments more precisely and accurately than with diffusion tensor imaging...
  7. ncbi request reprint High b-value q-space analyzed diffusion-weighted MRI: application to multiple sclerosis
    Y Assaf
    School of Chemistry, Raymond and Beverly Sackler Faculty of Exact Sciences, Tel Aviv University, Ramat Aviv, Tel Aviv, Israel
    Magn Reson Med 47:115-26. 2002
    ....
  8. ncbi request reprint The effect of rotational angle and experimental parameters on the diffraction patterns and micro-structural information obtained from q-space diffusion NMR: implication for diffusion in white matter fibers
    Liat Avram
    School of Chemistry, The Sackler Faculty of Exact Sciences, Tel Aviv University, Ramat Aviv, Tel Aviv 69978, Israel
    J Magn Reson 169:30-8. 2004
    ..In addition, it was found that large delta results in extraction of a compartment size, which is smaller than the real one. The relevance of these results to q-space MRI of neuronal tissues and fiber tracking is discussed...
  9. doi request reprint Combinatorial fiber-tracking of the human brain
    Shlomi Lifshits
    Department of Neurobiology, Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel
    Neuroimage 48:532-40. 2009
    ..While the DTI ellipsoid served as input for the algorithms, any diffusion imaging based orientation density function (ODF) can be used. This framework can potentially turn diffusion imaging tractography into a true connectivity measure...
  10. ncbi request reprint High b-value diffusion imaging of dementia: application to vascular dementia and alzheimer disease
    Orna Mayzel-Oreg
    School of Chemistry, The Sackler Faulty of Exact Sciences, Tel Aviv University, Ramat Aviv, Tel Aviv 69978, Israel
    J Neurol Sci 257:105-13. 2007
    ..Conventional diffusion tensor imaging did not show significant changes between either of the groups and controls. These results demonstrate the potential of high b-value DWI in the diagnosis of dementia...
  11. doi request reprint Free water elimination and mapping from diffusion MRI
    Ofer Pasternak
    Blavatnik School of Computer Science, Raymond and Beverly Sackler Faculty of Exact Sciences, Tel Aviv University, Tel Aviv, Israel
    Magn Reson Med 62:717-30. 2009
    ..The analysis requires a conventional DTI acquisition and can be easily merged with existing DTI pipelines...
  12. doi request reprint Structural correlates of memory performance with diffusion tensor imaging
    Efrat Sasson
    Department of Neurobiology, Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel
    Neuroimage 50:1231-42. 2010
    ....
  13. doi request reprint AxCaliber: a method for measuring axon diameter distribution from diffusion MRI
    Yaniv Assaf
    Department of Neurobiology, The George S Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel
    Magn Reson Med 59:1347-54. 2008
    ..Applications are expected in longitudinal studies designed to follow nerve growth in normal and abnormal development, as well as in diagnosing disorders and diseases affecting specific populations of axons in the CNS and PNS...
  14. ncbi request reprint Susceptibility-matched envelope for the correction of EPI artifacts
    Arnon Neufeld
    The Wohl Institute for Advanced Imaging, Tel Aviv Sourasky Medical Center, 6 Weizmann St, Tel Aviv 64239, Israel
    Magn Reson Imaging 23:947-51. 2005
    ..This method causes minimal patient inconvenience and no interference with any function of the scanner, thus yielding a simple and efficient solution for the correction of B(0) variation...
  15. doi request reprint Variational multiple-tensor fitting of fiber-ambiguous diffusion-weighted magnetic resonance imaging voxels
    Ofer Pasternak
    School of Computer Science, Tel Aviv University, Tel Aviv 69978, Israel
    Magn Reson Imaging 26:1133-44. 2008
    ..We compare the results with diffusion tensor imaging analysis and discuss applications for the framework...
  16. ncbi request reprint High b-value q-space analyzed diffusion-weighted MRS and MRI in neuronal tissues - a technical review
    Yoram Cohen
    School of Chemistry, The Raymond and Beverly Sackler Faculty of Exact Sciences, Tel Aviv University, Ramat Aviv, Israel
    NMR Biomed 15:516-42. 2002
    ..The potentials and caveats of this approach are outlined and experimental data are presented that show the effect of violating the short gradient pulse (SGP) approximation on the extracted parameters from the q-space analysis...
  17. doi request reprint Characterization of brain lesions in a mouse model of progressive multiple sclerosis
    H Levy
    Department of Neurobiology, George S Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel
    Exp Neurol 226:148-58. 2010
    ..We suggest using NOD mice as a suitable model for studying MS using MRI methods toward future diagnostic and drug development...
  18. ncbi request reprint Hypertension and neuronal degeneration in excised rat spinal cord studied by high-b value q-space diffusion magnetic resonance imaging
    Yaniv Assaf
    TEVA Pharmaceutical Industries Ltd and Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel
    Exp Neurol 184:726-36. 2003
    ..These results seem to indicate that high b value q-space DWI might be a sensitive method for following demyelination and axonal loss associated with vascular insults...
  19. ncbi request reprint Improved detectability of experimental allergic encephalomyelitis in excised swine spinal cords by high b-value q-space DWI
    Inbal E Biton
    School of Chemistry, The Sackler Faculty of Exact Sciences, Tel Aviv University, Ramat Aviv, Tel Aviv 69978, Israel
    Exp Neurol 195:437-46. 2005
    ..This improved detection level of the EAE model by high b-value q-space DWI over conventional T1-, and T2-weighted MRI is briefly discussed...
  20. ncbi request reprint Composite hindered and restricted model of diffusion (CHARMED) MR imaging of the human brain
    Yaniv Assaf
    Functional Brain Imaging Unit, The Wohl Institute for Advanced Imaging, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
    Neuroimage 27:48-58. 2005
    ..We also provide here an experimental design and analysis framework to implement CHARMED MRI that is feasible on human clinical scanners...
  21. pmc In vivo measurement of axon diameter distribution in the corpus callosum of rat brain
    Daniel Barazany
    Department of Neurobiology, The George S Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel
    Brain 132:1210-20. 2009
    ..Being a magnetic resonance imaging based methodology, AxCaliber has the potential to be used in human scanners for morphological studies of white matter in normal and abnormal development, and white matter related diseases...
  22. doi request reprint Neurodegeneration in thiamine deficient rats-A longitudinal MRI study
    Vered Dror
    Department of Physiology and Pharmacology, Sackler School of Medicine, Tel Aviv University, Ramat Aviv 69978, Israel
    Brain Res 1308:176-84. 2010
    ..This longitudinal MRI study demonstrated that in TD MRI can detect neurodegeneration and neuronal recovery. DTI is more sensitive than T(2) mapping in the early detection of TD lesions...
  23. ncbi request reprint Delineating gray and white matter involvement in brain lesions: three-dimensional alignment of functional magnetic resonance and diffusion-tensor imaging
    Talma Hendler
    Functional Brain Imaging Unit, Wohl Institute for Advanced Imaging, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
    J Neurosurg 99:1018-27. 2003
    ..The main objective of this study was to improve the presurgical assessment of critical functionality in the vicinity of brain lesions by combining DT and fMR imaging methodologies...
  24. doi request reprint A mouse model for eukaryotic translation initiation factor 2B-leucodystrophy reveals abnormal development of brain white matter
    Michal Geva
    Department of Cell Research and Immunology, George S Wise Faculty of Life Science, Tel Aviv University, Tel Aviv, Israel
    Brain 133:2448-61. 2010
    ..The anomalous development of white matter in Eif2b5(R132H/R132H) mice underscores the importance of tight translational control to normal myelin formation and maintenance...
  25. ncbi request reprint Diffusion tensor imaging of the median nerve in healthy and carpal tunnel syndrome subjects
    Dan Stein
    Department of Neurobiology, Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel
    J Magn Reson Imaging 29:657-62. 2009
    ..To determine if diffusion tensor imaging (DTI) of the median nerve could allow identification of patients with carpal tunnel syndrome (CTS)...
  26. doi request reprint Mesenchymal stem cells induced to secrete neurotrophic factors attenuate quinolinic acid toxicity: a potential therapy for Huntington's disease
    O Sadan
    Felsenstein Medical Research Center, Department of Neurology, Rabin Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Israel
    Exp Neurol 234:417-27. 2012
    ..We conclude that NTF cellular treatment could serve as a novel therapy for managing HD...
  27. doi request reprint Cluster analysis of resting-state fMRI time series
    Aviv Mezer
    Department of Biochemistry, Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel
    Neuroimage 45:1117-25. 2009
    ..These contributions may include head motions, the underling microvasculature anatomy and cellular morphology...
  28. ncbi request reprint Changes in axonal morphology in experimental autoimmune neuritis as studied by high b-value q-space (1)H and (2)H DQF diffusion magnetic resonance spectroscopy
    Yaniv Assaf
    School of Chemistry, The Raymond and Beverly Sackler Faculty of Exact Sciences, Tel Aviv University, Ramat Aviv, Tel Aviv, Israel
    Magn Reson Med 48:71-81. 2002
    ..This study demonstrates the utility of high-b-value q-space diffusion MRS for studying white matter-associated disorders in general...
  29. ncbi request reprint Virtual definition of neuronal tissue by cluster analysis of multi-parametric imaging (virtual-dot-com imaging)
    Yossi Yovel
    Department of Neurobiochemistry, Tel Aviv University, Ramat Aviv, Tel Aviv, Israel
    Neuroimage 35:58-69. 2007
    ..The implications of this methodology are far-ranging, from non-invasive, in vivo, individual mapping of histologically distinct brain areas to automatic identification of pathological processes...
  30. ncbi request reprint Structural changes in glutamate cell swelling followed by multiparametric q-space diffusion MR of excised rat spinal cord
    Inbal E Biton
    School of Chemistry, The Sackler Faculty of Exact Sciences, Tel Aviv University, Ramat Aviv, Tel Aviv 69978, Israel
    Magn Reson Imaging 22:661-72. 2004
    ..Multiparametric high b-value q-space diffusion MR is useful for obtaining microstructural information in neuronal tissues...
  31. ncbi request reprint Sleep-anticipating effects of melatonin in the human brain
    Tali Gorfine
    Department of Neurobiochemistry, The George S Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv 69978, Israel
    Neuroimage 31:410-8. 2006
    ..Our findings highlight the role of melatonin in priming sleep-associated brain activation patterns in anticipation of sleep...
  32. doi request reprint Can we use diffusion MRI as a bio-marker of neurodegenerative processes?
    Yaniv Assaf
    Department of Neurobiology, Faculty of Life Sciences, Tel Aviv University, Tel Aviv 69978, Israel
    Bioessays 30:1235-45. 2008
    ..We will overview the current applications of diffusion MRI and its relation to cellular biology of brain tissue...
  33. doi request reprint The combined treatment of Copaxone and Salirasib attenuates experimental autoimmune encephalomyelitis (EAE) in mice
    Elizabeta Aizman
    Department of Neurobiology, The George S Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel
    J Neuroimmunol 229:192-203. 2010
    ..5%, 77.5% and 82.5% of mice treated with vehicle, GA and FTS, respectively, results supported by MRI, histological, immunological and biochemical data. Such a combined treatment may improve clinical outcome in MS patients...
  34. ncbi request reprint Normal white matter development from infancy to adulthood: comparing diffusion tensor and high b value diffusion weighted MR images
    Dafna Ben Bashat
    The Wohl Institute for Advanced Imaging, Department of Radiology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
    J Magn Reson Imaging 21:503-11. 2005
    ....
  35. ncbi request reprint Regional axonal abnormalities in first episode schizophrenia: preliminary evidence based on high b-value diffusion-weighted imaging
    Avi Mendelsohn
    Department of Psychology, Tel Aviv University, Tel Aviv, Israel
    Psychiatry Res 146:223-9. 2006
    ..These preliminary results suggest that WM abnormality, as measured by high b-value DWI, is already a significant pathological brain marker in early stage of schizophrenia...
  36. doi request reprint Clozapine administration in adolescence prevents postpubertal emergence of brain structural pathology in an animal model of schizophrenia
    Yael Piontkewitz
    Department of Psychology, Tel Aviv University, Israel
    Biol Psychiatry 66:1038-46. 2009
    ..We used a neurodevelopmental animal model of schizophrenia to assess the efficacy of the atypical antipsychotic clozapine to prevent neuroanatomical deterioration...
  37. doi request reprint Three-dimensional water diffusion in impermeable cylindrical tubes: theory versus experiments
    Liat Avram
    School of Chemistry, The Raymond and Beverly Sackler Faculty of Exact Sciences, Tel Aviv University, Tel Aviv, Israel
    NMR Biomed 21:888-98. 2008
    ..This three-dimensional modeling framework should aid in describing diffusion in numerous biological systems and in a myriad of materials sciences applications...
  38. ncbi request reprint MRI evidence of white matter damage in a mouse model of Nijmegen breakage syndrome
    Yaniv Assaf
    Department of Neurobiochemistry, George S Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel
    Exp Neurol 209:181-91. 2008
    ..Myelin index and protein levels were significantly reduced in these brains. Our results point to a novel function of Nbs1 in the development and organization of the white matter...
  39. doi request reprint Dynamic changes in the recovery after traumatic brain injury in mice: effect of injury severity on T2-weighted MRI abnormalities, and motor and cognitive functions
    Jeanna Tsenter
    Department of Pharmacology, Hebrew University, Jerusalem, Israel
    J Neurotrauma 25:324-33. 2008
    ..The combined assessment of neurobehavioral and cognitive function along with MRI is most useful in evaluating recovery from injury, especially when testing effectiveness of novel treatments or genetic manipulations...