Y Assaf

..More specifically, we aimed at evaluating the ability of this methodology to identify tissue damage in the so-called normal-appearing white matter (NAWM)...

..This review summarizes the development of DTI in the last decade with respect to the specificity and utility of the technique in radiology and anatomy studies...

..This technique, therefore, might serve as a better indication for the extensive nerve fiber loss in the white matter that is caused by vascular disease...

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..With fMRI, one can more accurately define the seed ROI for DTI based tractography and to provide a more comprehensive, functionally related, white matter mapping, a very important tool used in pre-surgical mapping...

..This framework shows promise in determining the orientations of two or more fiber compartments more precisely and accurately than with diffusion tensor imaging...

..Applications are expected in longitudinal studies designed to follow nerve growth in normal and abnormal development, as well as in diagnosing disorders and diseases affecting specific populations of axons in the CNS and PNS...

..Conventional diffusion tensor imaging did not show significant changes between either of the groups and controls. These results demonstrate the potential of high b-value DWI in the diagnosis of dementia...

..While the DTI ellipsoid served as input for the algorithms, any diffusion imaging based orientation density function (ODF) can be used. This framework can potentially turn diffusion imaging tractography into a true connectivity measure...

..The analysis requires a conventional DTI acquisition and can be easily merged with existing DTI pipelines...

..We compare the results with diffusion tensor imaging analysis and discuss applications for the framework...

..This method causes minimal patient inconvenience and no interference with any function of the scanner, thus yielding a simple and efficient solution for the correction of B(0) variation...

..The potentials and caveats of this approach are outlined and experimental data are presented that show the effect of violating the short gradient pulse (SGP) approximation on the extracted parameters from the q-space analysis...

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..In addition, it was found that large delta results in extraction of a compartment size, which is smaller than the real one. The relevance of these results to q-space MRI of neuronal tissues and fiber tracking is discussed...

..We suggest using NOD mice as a suitable model for studying MS using MRI methods toward future diagnostic and drug development...

..These results seem to indicate that high b value q-space DWI might be a sensitive method for following demyelination and axonal loss associated with vascular insults...

..This improved detection level of the EAE model by high b-value q-space DWI over conventional T1-, and T2-weighted MRI is briefly discussed...

..We also provide here an experimental design and analysis framework to implement CHARMED MRI that is feasible on human clinical scanners...

..This longitudinal MRI study demonstrated that in TD MRI can detect neurodegeneration and neuronal recovery. DTI is more sensitive than T(2) mapping in the early detection of TD lesions...

..Being a magnetic resonance imaging based methodology, AxCaliber has the potential to be used in human scanners for morphological studies of white matter in normal and abnormal development, and white matter related diseases...

..The anomalous development of white matter in Eif2b5(R132H/R132H) mice underscores the importance of tight translational control to normal myelin formation and maintenance...

..To determine if diffusion tensor imaging (DTI) of the median nerve could allow identification of patients with carpal tunnel syndrome (CTS)...

..Furthermore, the use of three-dimensional visualization seems crucial and unique for viewing and understanding the complicated spatial relationship among the lesion, gray matter activation, and white matter fiber bundles...

..We conclude that NTF cellular treatment could serve as a novel therapy for managing HD...

..These contributions may include head motions, the underling microvasculature anatomy and cellular morphology...

..This study demonstrates the utility of high-b-value q-space diffusion MRS for studying white matter-associated disorders in general...

..The implications of this methodology are far-ranging, from non-invasive, in vivo, individual mapping of histologically distinct brain areas to automatic identification of pathological processes...

..Multiparametric high b-value q-space diffusion MR is useful for obtaining microstructural information in neuronal tissues...

..Our findings highlight the role of melatonin in priming sleep-associated brain activation patterns in anticipation of sleep...

..This three-dimensional modeling framework should aid in describing diffusion in numerous biological systems and in a myriad of materials sciences applications...

..5%, 77.5% and 82.5% of mice treated with vehicle, GA and FTS, respectively, results supported by MRI, histological, immunological and biochemical data. Such a combined treatment may improve clinical outcome in MS patients...

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..We used a neurodevelopmental animal model of schizophrenia to assess the efficacy of the atypical antipsychotic clozapine to prevent neuroanatomical deterioration...

..These preliminary results suggest that WM abnormality, as measured by high b-value DWI, is already a significant pathological brain marker in early stage of schizophrenia...

..We will overview the current applications of diffusion MRI and its relation to cellular biology of brain tissue...

..Myelin index and protein levels were significantly reduced in these brains. Our results point to a novel function of Nbs1 in the development and organization of the white matter...

..The combined assessment of neurobehavioral and cognitive function along with MRI is most useful in evaluating recovery from injury, especially when testing effectiveness of novel treatments or genetic manipulations...