Affiliation: Tel Aviv University
Cohen Tayar Y, Cohen H, Mitiagin Y, Abravanel Z, Levy C, Idelson M, et al
. Pax6 regulation of Sox9 in the mouse retinal pigmented epithelium controls its timely differentiation and choroid vasculature development. Development. 2018;145: pubmed publisher
..These factors might be involved in choroid development and in the pathogenesis of the common blinding disease: age-related macular degeneration (AMD). ..
Menuchin Lasowski Y, Oren Giladi P, Xie Q, Ezra Elia R, Ofri R, Peled Hajaj S, et al
. Sip1 regulates the generation of the inner nuclear layer retinal cell lineages in mammals. Development. 2016;143:2829-41 pubmed publisher
Ohana R, Weiman Kelman B, Raviv S, Tamm E, Pasmanik Chor M, Rinon A, et al
. MicroRNAs are essential for differentiation of the retinal pigmented epithelium and maturation of adjacent photoreceptors. Development. 2015;142:2487-98 pubmed publisher
..This study reveals the combined regulatory activity of miRNAs that is required for RPE differentiation and for the development of the adjacent neuroretina. ..
Gueta K, David A, Cohen T, Menuchin Lasowski Y, Nobel H, Narkis G, et al
. The stage-dependent roles of Ldb1 and functional redundancy with Ldb2 in mammalian retinogenesis. Development. 2016;143:4182-4192 pubmed
..An intricate regulatory network exists that is mediated by Ldb1 and Ldb2, and promotes RPC proliferation and multipotency; it also controls specification of mammalian retina cells. ..
Remez L, Onishi A, Menuchin Lasowski Y, Biran A, Blackshaw S, Wahlin K, et al
. Pax6 is essential for the generation of late-born retinal neurons and for inhibition of photoreceptor-fate during late stages of retinogenesis. Dev Biol. 2017;432:140-150 pubmed publisher
..Taken together, these data show that Pax6 acts in RPCs to control differentiation of multiple late-born neuronal cell types. ..