A Achiron

Summary

Affiliation: Tel Aviv University
Country: Israel

Publications

  1. ncbi request reprint T-cell vaccination in multiple sclerosis
    Anat Achiron
    Center for Multiple Sclerosis, Sheba Medical Center, Tel Hashomer 52621, Israel
    Autoimmun Rev 3:25-32. 2004
  2. pmc Unique gene expression patterns in human T-cell lines generated from multiple sclerosis patients by stimulation with a synthetic MOG peptide
    Mathilda Mandel
    Blood Center, Sheba Medical Center, Tel Hashomer 52621, Israel
    Clin Dev Immunol 12:203-9. 2005
  3. pmc Prediction of acute multiple sclerosis relapses by transcription levels of peripheral blood cells
    Michael Gurevich
    Multiple Sclerosis Center, Sheba Medical Center, Tel Hashomer, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
    BMC Med Genomics 2:46. 2009
  4. doi request reprint Characterization of multiple sclerosis traits: nuclear receptors (NR) impaired apoptosis pathway and the role of 1-α 25-dihydroxyvitamin D3
    Anat Achiron
    Multiple Sclerosis Center, Sheba Medical Center, and Sackler School of Medicine Tel Aviv University, Israel
    J Neurol Sci 311:9-14. 2011
  5. pmc Understanding autoimmune mechanisms in multiple sclerosis using gene expression microarrays: treatment effect and cytokine-related pathways
    A Achiron
    Sheba Medical Center, Tel Hashomer, and Sackler School of Medicine, Tel Aviv University, 52621, Israel
    Clin Dev Immunol 11:299-305. 2004
  6. ncbi request reprint Predicting the course of relapsing-remitting MS using longitudinal disability curves
    Anat Achiron
    Multiple Sclerosis, Center Sheba Medical Center affiliated to Tel Aviv University, Sackler School of Medicine, Israel, Tel Hashomer, Israel
    J Neurol 251:v65-v68. 2004
  7. ncbi request reprint [Multiple sclerosis and anti-phospholipid syndrome--one or two diseases?]
    Anat Achiron
    The Center for Multiple Sclerosis, Sheba Medical Center, Tel Hashomer
    Harefuah 143:724-6, 766, 765. 2004
  8. ncbi request reprint Intravenous immunoglobulin treatment following the first demyelinating event suggestive of multiple sclerosis: a randomized, double-blind, placebo-controlled trial
    Anat Achiron
    Multiple Sclerosis Center and Neuroradiology Unit, Sheba Medical Center, Tel Hashomer 52621, Israel
    Arch Neurol 61:1515-20. 2004
  9. ncbi request reprint Bone strength in multiple sclerosis: cortical midtibial speed-of-sound assessment
    Anat Achiron
    Multiple Sclerosis Center, Sheba Medical Center, Tel Hashomer, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
    Mult Scler 10:488-93. 2004
  10. ncbi request reprint T cell vaccination in multiple sclerosis relapsing-remitting nonresponders patients
    A Achiron
    Multiple Sclerosis Center, Sheba Medical Center, Tel Hashomer, Israel
    Clin Immunol 113:155-60. 2004

Detail Information

Publications77

  1. ncbi request reprint T-cell vaccination in multiple sclerosis
    Anat Achiron
    Center for Multiple Sclerosis, Sheba Medical Center, Tel Hashomer 52621, Israel
    Autoimmun Rev 3:25-32. 2004
    ..Specifically, it is important to examine the effect of early TCV, given after the first episode suggestive of the disease, in order to prevent the process of epitope spreading...
  2. pmc Unique gene expression patterns in human T-cell lines generated from multiple sclerosis patients by stimulation with a synthetic MOG peptide
    Mathilda Mandel
    Blood Center, Sheba Medical Center, Tel Hashomer 52621, Israel
    Clin Dev Immunol 12:203-9. 2005
    ....
  3. pmc Prediction of acute multiple sclerosis relapses by transcription levels of peripheral blood cells
    Michael Gurevich
    Multiple Sclerosis Center, Sheba Medical Center, Tel Hashomer, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
    BMC Med Genomics 2:46. 2009
    ..Similar approach can be also useful for dealing with other autoimmune diseases that characterized by relapsing-remitting nature...
  4. doi request reprint Characterization of multiple sclerosis traits: nuclear receptors (NR) impaired apoptosis pathway and the role of 1-α 25-dihydroxyvitamin D3
    Anat Achiron
    Multiple Sclerosis Center, Sheba Medical Center, and Sackler School of Medicine Tel Aviv University, Israel
    J Neurol Sci 311:9-14. 2011
    ..These findings prove a role for Vit D(3) as a possible therapeutic intervention in MS patients aimed to activate the repressed apoptosis and enhance better control of the disease...
  5. pmc Understanding autoimmune mechanisms in multiple sclerosis using gene expression microarrays: treatment effect and cytokine-related pathways
    A Achiron
    Sheba Medical Center, Tel Hashomer, and Sackler School of Medicine, Tel Aviv University, 52621, Israel
    Clin Dev Immunol 11:299-305. 2004
    ..Our results indicate that cytokine-associated genes are involved in various pathogenic pathways in MS and also related to immunomodulatory treatment effects...
  6. ncbi request reprint Predicting the course of relapsing-remitting MS using longitudinal disability curves
    Anat Achiron
    Multiple Sclerosis, Center Sheba Medical Center affiliated to Tel Aviv University, Sackler School of Medicine, Israel, Tel Hashomer, Israel
    J Neurol 251:v65-v68. 2004
    ..The aim of this review is to present longitudinal disability curves enabling the assessment of disease progression in patients with relapsing-remitting (RR)MS...
  7. ncbi request reprint [Multiple sclerosis and anti-phospholipid syndrome--one or two diseases?]
    Anat Achiron
    The Center for Multiple Sclerosis, Sheba Medical Center, Tel Hashomer
    Harefuah 143:724-6, 766, 765. 2004
    ..The current review approaches this problem and discusses whether multiple sclerosis and anti-phospholipid syndrome are actually one or two diseases...
  8. ncbi request reprint Intravenous immunoglobulin treatment following the first demyelinating event suggestive of multiple sclerosis: a randomized, double-blind, placebo-controlled trial
    Anat Achiron
    Multiple Sclerosis Center and Neuroradiology Unit, Sheba Medical Center, Tel Hashomer 52621, Israel
    Arch Neurol 61:1515-20. 2004
    ....
  9. ncbi request reprint Bone strength in multiple sclerosis: cortical midtibial speed-of-sound assessment
    Anat Achiron
    Multiple Sclerosis Center, Sheba Medical Center, Tel Hashomer, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
    Mult Scler 10:488-93. 2004
    ..05). Bone strength was preserved in MS patients. In a subgroup of female patients increased SOS was conceivably related to spasticity...
  10. ncbi request reprint T cell vaccination in multiple sclerosis relapsing-remitting nonresponders patients
    A Achiron
    Multiple Sclerosis Center, Sheba Medical Center, Tel Hashomer, Israel
    Clin Immunol 113:155-60. 2004
    ..TCV could serve as a potential alternative therapy for this subgroup of nonresponders patients...
  11. ncbi request reprint Effect of intravenous immunoglobulin treatment on pregnancy and postpartum-related relapses in multiple sclerosis
    Anat Achiron
    Multiple Sclerosis Center, Sheba Medical Center, Sacker School of Medicine, Tel Aviv University, Tel Aviv, Israel, Tel Hashomer 52621, Israel
    J Neurol 251:1133-7. 2004
    ..Further randomized double-blind studies are needed to confirm our findings...
  12. ncbi request reprint Blood transcriptional signatures of multiple sclerosis: unique gene expression of disease activity
    Anat Achiron
    Multiple Sclerosis Center, Sheba Medical Center, Tel Hashomer 52621, Israel
    Ann Neurol 55:410-7. 2004
    ....
  13. ncbi request reprint Cancer incidence in multiple sclerosis and effects of immunomodulatory treatments
    Anat Achiron
    Multiple Sclerosis Center, Sheba Medical Center, Tel Hashomer, Sacker School of Medicine, Tel Aviv University, Tel Aviv, Israel
    Breast Cancer Res Treat 89:265-70. 2005
    ..122 and 0.072, respectively). Further study is needed to assess possible associations between long-term exposure to the novel immunomodulatory treatments in MS and rate of cancer...
  14. ncbi request reprint Intravenous immunoglobulin and multiple sclerosis
    Anat Achiron
    Multiple Sclerosis Center, Sheba Medical Center, Tel Hashomer, Israel
    Clin Rev Allergy Immunol 29:247-54. 2005
    ..In the current review, we summarize the up-to-date data related to IVIg clinical trials in MS, and the suggested mechanisms of action by which IVIg modulates the relevant immunological pathways impaired in MS...
  15. pmc Cognitive patterns and progression in multiple sclerosis: construction and validation of percentile curves
    A Achiron
    Multiple Sclerosis Center, Sheba Medical Center, Tel Hashomer 52621, Israel
    J Neurol Neurosurg Psychiatry 76:744-9. 2005
    ..The present study aimed to identify correlations between cognitive tests and disease duration, construct longitudinal cognitive curves, and assess pattern of change over time...
  16. doi request reprint Microarray analysis identifies altered regulation of nuclear receptor family members in the pre-disease state of multiple sclerosis
    Anat Achiron
    Multiple Sclerosis Center, Sheba Medical Center, Tel Hashomer, Israel
    Neurobiol Dis 38:201-9. 2010
    ....
  17. ncbi request reprint [Physical activity: positive impact on brain plasticity]
    Anat Achiron
    Multiple Sclerosis Center, Sheba Medical Center, Tel Hashomer, Israel
    Harefuah 147:252-5, 276. 2008
    ..Physical activity should be employed as a tool to improve neural function in healthy subjects and in patients suffering from neurological damage...
  18. ncbi request reprint Prolonged response times characterize cognitive performance in multiple sclerosis
    A Achiron
    Multiple Sclerosis Center, Sheba Medical Center, Tel Hashomer, Israel
    Eur J Neurol 14:1102-8. 2007
    ..We conclude that in MS prolonged response times on a range of cognitive tasks signify abnormal conduction within demyelinative tracts...
  19. ncbi request reprint Impaired expression of peripheral blood apoptotic-related gene transcripts in acute multiple sclerosis relapse
    Anat Achiron
    Multiple Sclerosis Center, Sheba Medical Center, Tel Hashomer, 52621, Israel
    Ann N Y Acad Sci 1107:155-67. 2007
    ..This suggests that the inflammatory process in active disease is targeted by inhibition of proapoptotic and repression of antiapoptotic genes that allow prolonged abnormal immune responses...
  20. pmc Zinc-ion binding and cytokine activity regulation pathways predicts outcome in relapsing-remitting multiple sclerosis
    A Achiron
    Multiple Sclerosis Center, Sheba Medical Center, Tel Hashomer, Sackler School of Medicine, Tel Aviv University, Israel
    Clin Exp Immunol 149:235-42. 2007
    ..Our findings provide a basis for monitoring patients by prediction of disease outcome and can be incorporated into clinical decision-making in relapsing-remitting MS...
  21. ncbi request reprint Peripheral blood gene expression signature mirrors central nervous system disease: the model of multiple sclerosis
    A Achiron
    Multiple Sclerosis Center, Sheba Medical Center, Tel Hashomer, Sackler School of Medicine, Tel Aviv University, Tel Hashomer, Israel
    Autoimmun Rev 5:517-22. 2006
    ....
  22. ncbi request reprint Cognitive changes in early MS: a call for a common framework
    A Achiron
    Multiple Sclerosis Center, Sheba Medical Center, Tel Hashomer, 52621, Israel, affiliated with the Sackler Faculty of Medicine, Tel Aviv University, Israel
    J Neurol Sci 245:47-51. 2006
    ..The present review proposes a framework aimed to help neurologists in approaching cognitive impairment in early MS and stimulate discussions and evaluations of the suggested recommendations...
  23. ncbi request reprint Does the flap of a butterfly's wings in Brazil set off a tornado in Texas?--The JC Virus Story in multiple sclerosis
    Anat Achiron
    Multiple Sclerosis Center, Sheba Medical Center, Tel Hashomer, Israel
    Isr Med Assoc J 7:283-5. 2005
  24. ncbi request reprint Longitudinal disability curves for predicting the course of relapsing-remitting multiple sclerosis
    Anat Achiron
    Multiple Sclerosis Center, Sheba Medical Center, Tel Hashomer, Israel
    Mult Scler 9:486-91. 2003
    ..Identifying the rate of progression of disability for an individual patient early in the disease process can influence treatment decisions as well as enable monitoring of the disease overtime...
  25. ncbi request reprint Immunoglobulin treatment in refractory Myasthenia gravis
    A Achiron
    Neuroimmunology Unit, Sheba Medical Center, Tel Hashomer, 52621 Israel
    Muscle Nerve 23:551-5. 2000
    ..01). Intravenous Ig therapy seems to be highly potent for inducing rapid improvement in refractory myasthenia during acute deterioration as well as for maintaining remission...
  26. doi request reprint Gender effects in relapsing-remitting multiple sclerosis: correlation between clinical variables and gene expression molecular pathways
    A Achiron
    Multiple Sclerosis Center, Sheba Medical Center, Tel Hashomer and Sackler School of Medicine, Tel Aviv University, Israel
    J Neurol Sci 286:47-53. 2009
    ..Our findings open possibilities to explore gender-dependent immunomodulatory treatments that will be based on gene expression mechanisms that set the difference between male and female RRMS patients...
  27. ncbi request reprint Multiple sclerosis-from probable to definite diagnosis: a 7-year prospective study
    A Achiron
    Multiple Sclerosis Center, Sheba Medical Center, Tel Hashomer 52621, Israel
    Arch Neurol 57:974-9. 2000
    ..To investigate the rate of progression from probable to clinically definite multiple sclerosis (MS) and to define patients who had rapidly (within 1 year) progressed to a definite diagnosis...
  28. ncbi request reprint Dexanabinol (HU-211) effect on experimental autoimmune encephalomyelitis: implications for the treatment of acute relapses of multiple sclerosis
    A Achiron
    Multiple Sclerosis Center, Sheba Medical Center, Ramat Gan, Israel
    J Neuroimmunol 102:26-31. 2000
    ..The results suggest that dexanabinol may provide an alternative mode of treatment for acute exacerbations of multiple sclerosis (MS)...
  29. pmc Cognitive impairment in probable multiple sclerosis
    A Achiron
    Multiple Sclerosis Center, Sheba Medical Center, Tel Hashomer, 52621 Israel
    J Neurol Neurosurg Psychiatry 74:443-6. 2003
    ..To evaluate and characterise cognitive impairment in the very early stage of multiple sclerosis (MS), in which patients are still diagnosed as suffering from probable MS...
  30. ncbi request reprint Fluoxetine treatment for weight reduction in steroid-induced obesity: a pilot study in myasthenia gravis patients
    A Achiron
    Sheba Medical Center, affiliated to the Sackler Faculty of Medicine, Tel Aviv University Tel Hashomer, Israel
    Eur Neuropsychopharmacol 9:111-3. 1999
    ..8 to 32.2 kg/m2 over the study period. No significant side effects were noted. We conclude that patients suffering from steroid-induced obesity respond to fluoxetine treatment of overweight by significant weight loss...
  31. ncbi request reprint Brain MRI lesion load quantification in multiple sclerosis: a comparison between automated multispectral and semi-automated thresholding computer-assisted techniques
    Anat Achiron
    Multiple Sclerosis Center, Sheba Medical Center, Tel Hashomer, Israel
    Magn Reson Imaging 20:713-20. 2002
    ..The MSA multispectral technique is a promising tool for evaluating MS patients. Non-biased recognition and delineation algorithms enable high accuracy, low intra-and inter-observer variances and fast assessment of MS related lesion load...
  32. doi request reprint Laquinimod suppress antigen presentation in relapsing-remitting multiple sclerosis: in-vitro high-throughput gene expression study
    M Gurevich
    Multiple Sclerosis Center, Sheba Medical Center, Tel Hashomer, Israel
    J Neuroimmunol 221:87-94. 2010
    ..These findings were demonstrated mainly via the NFkB pathway. Analysis of PBMC subpopulations identified activation of Th2 response in CD14+ and CD4+ cells and suppression of proliferation in CD8+ cells...
  33. ncbi request reprint Analysis of allelic association between D6S461 marker and multiple sclerosis in Ashkenazi and Iraqi Jewish patients
    Y Shinar
    Multiple Sclerosis Center, Sheba Medical Center, Tel Hashomer, Israel
    J Mol Neurosci 11:265-9. 1998
    ..5% of the 260-bp allele (n = 121, p = 0.045). The results suggest that the D6S461 region may contain a locus contributing to an early onset of relapsing-remitting MS...
  34. pmc Autoimmunity gene expression portrait: specific signature that intersects or differentiates between multiple sclerosis and systemic lupus erythematosus
    M Mandel
    Blood Bank, Sheba Medical Centre, Tel Hashomer, Israel
    Clin Exp Immunol 138:164-70. 2004
    ..These results provide insights into the genetic pathways underlying autoimmune diseases, and identify specific disease-associated signatures that may enable targetted disease-related specific therapies to be developed...
  35. ncbi request reprint Late-onset multiple sclerosis
    M L Polliack
    Multiple Sclerosis Center, Sheba Medical Center, Tel-Hashomer, Israel
    J Am Geriatr Soc 49:168-71. 2001
    ....
  36. doi request reprint Common and specific signatures of gene expression and protein-protein interactions in autoimmune diseases
    T Tuller
    School of Medicine, Tel Aviv University, Ramat Aviv, Israel
    Genes Immun 14:67-82. 2013
    ..The relevant genes and pathways reported in this study are discussed at length, and may be helpful in the diagnoses and understanding of autoimmunity and/or specific autoimmune diseases...
  37. ncbi request reprint Effect of a cognitive task on postural control in patients with a clinically isolated syndrome suggestive of multiple sclerosis
    A Kalron
    Multiple Sclerosis Center, Sheba Medical Center, Tel Hashomer Israel and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    Eur J Phys Rehabil Med 47:579-86. 2011
    ..As postural control consumes attentional resources, it is essential to test stability during a cognitive task...
  38. ncbi request reprint Gene expression studies in systemic lupus erythematosus
    M Mandel
    Blood Center, Sheba Medical Center, Tel Hashomer, Israel
    Lupus 15:451-6. 2006
    ....
  39. doi request reprint Molecular profiling of glatiramer acetate early treatment effects in multiple sclerosis
    Anat Achiron
    Multiple Sclerosis Center, Sheba Medical Center, Tel Hashomer, Israel
    Dis Markers 27:63-73. 2009
    ..Glatiramer acetate (GA, Copaxone) has beneficial effects on the clinical course of relapsing-remitting multiple sclerosis (RRMS). However, the exact molecular mechanisms of GA effects are only partially understood...
  40. ncbi request reprint Chemokine polymorphisms: candidates for MS susceptibility and disease course
    A Achiron
    Multiple Sclerosis Centre, Sheba Medical Centre, Tel Hashomer, Israel
    Int MS J 11:71-7. 2004
    ..This is due to the key role chemokines play in the physiology of inflammation and regulation of central nervous system trafficking across the blood-brain barrier, and their exploitation by certain micro-organisms to initiate infection...
  41. ncbi request reprint Sex-related differences in the development of the human fetal corpus callosum: in utero ultrasonographic study
    R Achiron
    Diagnostic Ultrasound Unit, Department of Obstetrics and Gynecology, The Chaim Sheba Medical Center, Tel Hashomer, and Faculty of Medicine, Tel Aviv University, Israel
    Prenat Diagn 21:116-20. 2001
    ..These findings support previous studies suggesting sex dimorphism of human CC and raise the possibility that prenatal sex hormones may play a role in determining callosal development...
  42. ncbi request reprint Common mutations in the familial Mediterranean fever gene associate with rapid progression to disability in non-Ashkenazi Jewish multiple sclerosis patients
    Y Shinar
    Heller Institute of Medical Research, Sheba Medical Center, Tel Hashomer, Israel
    Genes Immun 4:197-203. 2003
    ..In conclusion, non-Asheknazi MS patients carrying one mutated MEFV gene, particularly M694V, expressed rapid progression to disability. The expressed mutation may increase inflammatory damage inflicted by autoimmune responses...
  43. doi request reprint Lessons from randomised direct comparative trials
    Anat Achiron
    Multiple Sclerosis Center, Sheba Medical Center, Tel Hashomer, and Sackler School of Medicine, Tel Aviv University, Israel
    J Neurol Sci 277:S19-24. 2009
    ..The results of the direct comparative studies provide evidence that glatiramer acetate and high-dose interferon-beta preparations have comparable clinical efficacy...
  44. ncbi request reprint Interaction of disease-related antigen-reactive T-cell lines from multiple sclerosis patients with type IV collagen: role of integrin VLA-1 and effects of irradiation
    Ilan Bank
    Department of Medicine F, Sheba Medical Center and Tel Aviv University, Tel Hashomer, Israel
    J Clin Immunol 22:153-63. 2002
    ..These findings may have important implications for understanding the pathogenesis of MS and how irradiation of potentially pathogenic T cells produces a reagent with possible therapeutic effects in T-cell vaccination (TCV)...
  45. ncbi request reprint A mutated CCR5 gene may have favorable prognostic implications in MS
    Rami Kantor
    Division of Infectious Diseases, Sheba Medical Center, Tel Hashomer, Israel
    Neurology 61:238-40. 2003
    ..Progression to disability was prolonged in Delta32CCR5 homozygotes and heterozygotes compared with MS patients with the CCR5 wild-type genotype (p < 0.005). Mutated CCR5 allele may be considered a favorable prognostic factor in MS...
  46. ncbi request reprint Reflexology treatment relieves symptoms of multiple sclerosis: a randomized controlled study
    I Siev-Ner
    Complementary Medicine Clinic, Department of Orthopedic Rehabilitation, Sheba Medical Center, Tel Hashomer, Israel
    Mult Scler 9:356-61. 2003
    ..To evaluate the effect of reflexology on symptoms of multiple sclerosis (MS) in a randomized, sham-controlled clinical trial...
  47. ncbi request reprint Development of the human fetal corpus callosum: a high-resolution, cross-sectional sonographic study
    R Achiron
    Department of Obstetrics and Gynecology, The Chaim Sheba Medical Center, Tel Hashomer, Israel
    Ultrasound Obstet Gynecol 18:343-7. 2001
    ..To establish reference ranges during human pregnancy for normal fetal corpus callosum dimensions...
  48. ncbi request reprint Effect of interferon-beta-1b on cognitive functions in multiple sclerosis
    Yoram Barak
    Multiple Sclerosis Center, Sheba Medical Center, Tel Hashomer, Israel
    Eur Neurol 47:11-4. 2002
    ..Multiple sclerosis (MS) is recognised as a central nervous system disease also affecting cognition. The rate of cognitive dysfunction in MS is in the range of 45-65% and adversely affect the quality of life...
  49. ncbi request reprint Cognitive fatigue in multiple sclerosis: findings from a two-wave screening project
    Yoram Barak
    Multiple Sclerosis Center, Sheba Medical Center, Tel Hashomer, affiliated with the Sackler Faculty of Medicine, Tel Aviv University, Israel
    J Neurol Sci 245:73-6. 2006
    ..However, the relationship of fatigue to cognitive functions and its impact on quality of life have not been widely studied...
  50. pmc Clone clusters in autoreactive CD4 T-cell lines from probable multiple sclerosis patients form disease-characteristic signatures
    Mathilda Mandel
    Blood Centre, Sheba Medical Centre, Tel Hashomer, 52621, Israel
    Immunology 128:287-300. 2009
    ..Analyses of clonal-clustering patterns may potentially aid in subclassification of MS or in characterizing aetiological agents of this disease...
  51. ncbi request reprint Circulatory neurosteroid levels in underweight female adolescent anorexia nervosa inpatients and following weight restoration
    D Stein
    Pediatric Psychosomatic Department, Chaim Sheba Medical Center, Tel Hashomer, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    Eur Neuropsychopharmacol 15:647-53. 2005
    ..DHEA(-S) levels following weight restoration, may in part account for the feeding difficulties in AN, particularly during refeeding...
  52. ncbi request reprint Lack of evidence for an association between two genetic polymorphisms in the tumor necrosis factor receptor 1 gene and multiple sclerosis in Ashkenazi Jews
    E Pras
    Danek Gertner Institute of Human Genetics, Sheba Medical Center, Tel Hashomer, Israel
    Eur Neurol 46:153-5. 2001
    ..No significant differences were observed for both polymorphisms between the patients and the controls. These findings suggest that genetic variants in TNFR1 do not play a significant role in Ashkenazi Jews...
  53. doi request reprint Suicide attempts of schizophrenia patients: a case-controlled study in tertiary care
    Yoram Barak
    Abarbanel Mental Health Center, Sackler School of Medicine, Tel Aviv University, Bat Yam, Israel
    J Psychiatr Res 42:822-6. 2008
    ..However, there is paucity of data regarding suicide attempts by schizophrenia patients. The aim of the present study was to characterize a large sample of schizophrenia patients in tertiary care who had attempted suicide...
  54. ncbi request reprint Long term safety of IVIg therapy in multiple sclerosis: 10 years experience
    Uriel Katz
    Department of Internal Medicine B, Center for Autoimmune Diseases, The Chaim Sheba Medical Center, Tel Hashomer, 52621, Israel
    Autoimmunity 39:513-7. 2006
    ..Adverse events during the loading dose did not predict adverse events during the maintenance phase. No severe adverse events were recorded. We conclude that IVIg is a safe therapy in MS either for short or for long-term periods...
  55. ncbi request reprint Perspectives in multiple sclerosis health care: special focus on the costs of multiple sclerosis
    Zeev Rotstein
    Multiple Sclerosis Center, Sheba Medical Center, Tel Hashomer, Sackler School of Medicine, Tel Aviv University, Israel
    Autoimmun Rev 5:511-6. 2006
    ....
  56. doi request reprint Gait analysis in multiple sclerosis: characterization of temporal-spatial parameters using GAITRite functional ambulation system
    Uri Givon
    Department of Pediatric Orthopaedics, Safra Hospital for Children and Motion Analysis Laboratory, Sheba Medical Center, Tel Hashomer, Israel
    Gait Posture 29:138-42. 2009
    ..However, specific characterization of abnormal gait in MS patients has only been described in small groups of patients, mainly using observational tools...
  57. ncbi request reprint Bowel circulation in normally grown and growth-restricted fetuses
    Zvi Kivilevitch
    Ultrasound Unit, Department of Obstetrics and Gynecology, Chaim Sheba Medical Center, Tel Hashomer, 52621 Ramat Gan, Israel
    J Ultrasound Med 30:1529-37. 2011
    ..The purpose of this study was to characterize bowel blood flow and its relationship with cerebral and placental circulations in normally grown and growth-restricted fetuses...
  58. doi request reprint Effect of craniosacral therapy on lower urinary tract signs and symptoms in multiple sclerosis
    Gil Raviv
    Urology Department, Sheba Medical Center, Tel Hashomer, Israel
    Complement Ther Clin Pract 15:72-5. 2009
    ..001>p>0.0001). CST was found to be an effective means for treating lower urinary tract symptoms and improving quality of life in MS patients...
  59. doi request reprint Happiness and neurological diseases
    Yoram Barak
    MS Center, Sheba Medical Center, Tel Hashomer and the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, 52612, Israel
    Expert Rev Neurother 9:445-59. 2009
    ....
  60. ncbi request reprint Sandlike appearance of Virchow-Robin spaces in early multiple sclerosis: a novel neuroradiologic marker
    Anat Achiron
    Multiple Sclerosis Center, Sheba Medical Center, Tel Hashomer, Israel
    AJNR Am J Neuroradiol 23:376-80. 2002
    ..However, Virchow-Robin spaces (VRSs), especially in early MS, have not been described. Our purpose was to determine the frequency of VRSs in recent-onset MS...
  61. ncbi request reprint Application of spherical harmonics derived space rotation invariant indices to the analysis of multiple sclerosis lesions' geometry by MRI
    Daniel Goldberg-Zimring
    Multiple Sclerosis Center, Sheba Medical Center, Tel Hashomer, Israel
    Magn Reson Imaging 22:815-25. 2004
    ..In conclusion, our proposed method circumvents the need for precise patient repositioning and can be advantageous in MRI longitudinal studies of MS patients...
  62. ncbi request reprint Screening for early cognitive impairment in multiple sclerosis patients using the clock drawing test
    Yoram Barak
    The Doly Steindling Multiple Sclerosis Center, Sheba Medical Center, Tel Hashomer, Israel
    J Clin Neurosci 9:629-32. 2002
    ..The absence of correlation with total EDSS score coupled with significant correlation with the mental functional system suggests that the CDT may be useful for screening MS patients...
  63. ncbi request reprint Safety of intravenous immunoglobulin (IVIG) therapy
    Uriel Katz
    Center for Autoimmune Diseases, Department of Internal Medicine B, The Chaim Sheba Medical Center, Tel Hashomer 52621, Israel
    Autoimmun Rev 6:257-9. 2007
    ..We conclude that IVIg is a safe therapy when given in a slow infusion rate in well-hydrated patients, better avoiding patients with known risk factors...
  64. pmc Can blood gene expression predict which patients with multiple sclerosis will respond to interferon?
    Naftali Kaminski
    Division of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    PLoS Med 2:e33; quiz e51. 2005
  65. ncbi request reprint Reduced cancer incidence among patients with schizophrenia
    Yoram Barak
    Psychogeriatric Department, Abarbanel Mental Health Center, Bat Yam, Israel
    Cancer 104:2817-21. 2005
    ..The current study was performed to evaluate the frequency of cancer in a large cohort of patients with schizophrenia and to determine the standardized incidence ratios (SIRs) of any malignancy in this group...
  66. ncbi request reprint G-CSF enhances the adhesion of encephalitogenic T cells to extracellular matrix components: a possible mechanism for exacerbation of multiple sclerosis
    Omri Snir
    Faculty of Life Science, Bar Ilan University, Ramat Gan, Israel
    J Neuroimmunol 172:145-55. 2006
    ..We propose a link between clinical worsening of MS symptoms induced by G-CSF and the hyperstimulation of T cell adhesion to ECM elicited by G-CSF...
  67. ncbi request reprint Selecting a disease-modifying agent as platform therapy in the long-term management of multiple sclerosis
    William H Stuart
    Peachtree Neurological Clinic, 3200 Downwood Circle, Suite 550, Atlanta, Georgia 30327, USA
    Neurology 63:S19-27. 2004
    ..Research is ongoing to identify other appropriate add-on agents (e.g., antigen-specific therapies) to be used in combination with existing DMAs to effectively manage MS...
  68. doi request reprint Breast cancer in women suffering from serious mental illness
    Yoram Barak
    Psychogeriatric Department, Abarbanel Mental Health Center, Bat Yam, Israel
    Schizophr Res 102:249-53. 2008
    ..However, it has been argued that psychiatric morbidity itself may be the confounding factor that affects cancer incidence and not particularly schizophrenia...
  69. ncbi request reprint Concordance for cognitive impairment: a study of 50 community-dwelling elderly female-female twin pairs
    Yoram Barak
    Pyschogeriatric Department, Abarbanel Mental Health Center, Bat Yam, Israel
    Compr Psychiatry 44:117-20. 2003
    ....
  70. ncbi request reprint Dysregulation of affect in multiple sclerosis: new phenomenological approach
    Yermi Harel
    Lewenstein Rehabilitation Hospital, Raanana, Israel
    Psychiatry Clin Neurosci 61:94-8. 2007
    ..It is concluded that the new phenomenological definition of DyA aids in distinguishing this symptom from other psychopathologies and can serve as a tool for neurologists in defining this unique entity...
  71. ncbi request reprint Three-dimensional analysis of the geometry of individual multiple sclerosis lesions: detection of shape changes over time using spherical harmonics
    Daniel Goldberg-Zimring
    Department of Biomedical Engineering, Technion, Israel Institute of Technology, Haifa, Israel
    J Magn Reson Imaging 18:291-301. 2003
    ..To suggest a quantitative method for assessing the temporal changes in the geometry of individual multiple sclerosis (MS) lesions in follow-up studies of MS patients...
  72. ncbi request reprint Randomized, controlled trial of dextromethorphan/quinidine for pseudobulbar affect in multiple sclerosis
    Hillel S Panitch
    Neurology Health Care Service, Fletcher Allen Health Care, University of Vermont, Burlington, 05401, USA
    Ann Neurol 59:780-7. 2006
    ....
  73. ncbi request reprint Alfacalcidol treatment in multiple sclerosis
    Anat Achiron
    Clin Neuropharmacol 26:53. 2003
  74. ncbi request reprint Very late-onset schizophrenia-like psychosis: clinical and imaging characteristics in comparison with elderly patients with schizophrenia
    Yoram Barak
    Psychogeriatric Department, Abarbanel Mental Health Center, 15 KKL Street, Bat Yam 59100, Israel
    J Nerv Ment Dis 190:733-6. 2002
    ..The authors suggest that VLOSLP is a valid diagnostic entity and that its features imply that involvement of neurodegenerative process may be etiologically relevant to psychosis with onset in late life...
  75. pmc Assessment of multiple sclerosis lesions with spherical harmonics: comparison of MR imaging and pathologic findings
    Daniel Goldberg-Zimring
    Department of Biomedical Engineering, Technion, Israel Institute of Technology, Haifa, Israel
    Radiology 235:1036-44. 2005
    ..Mean DSC was significantly higher than 70% (P < .001). SH method provided unbiased lesion volume and added geometric information that may enable a better understanding of the pathogenesis and lesion evolution over time...
  76. ncbi request reprint Therapeutic considerations for disease progression in multiple sclerosis: evidence, experience, and future expectations
    Elliot M Frohman
    Department of Ophthalmology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Arch Neurol 62:1519-30. 2005
    ....
  77. ncbi request reprint Human T-lymphotropic virus type-1 (HTLV-1) in Israeli patients and their family relatives and its transmission to rats
    Michael Shohat
    Department of Dermatology, Rabin Medical Center, Petah T ikva, Israel
    Med Microbiol Immunol 195:93-9. 2006
    ....