Jacob Ablin

Summary

Affiliation: Tel Aviv University
Country: Israel

Publications

  1. doi request reprint Pathogenesis of fibromyalgia - a review
    Jacob Ablin
    Department of Rheumatology, Institute of Rheumatology, Tel Aviv Sourasky Medical Center and Sackler Faculty of Medicine, 6 Weizman St, Tel Aviv University, Tel Aviv 64239, Israel
    Joint Bone Spine 75:273-9. 2008
  2. ncbi request reprint Effects of sleep restriction and exercise deprivation on somatic symptoms and mood in healthy adults
    Jacob N Ablin
    Institute of Rheumatology, Sourasky Medical Center, and Tel Aviv University faculty of Medicine, Israel
    Clin Exp Rheumatol 31:S53-9. 2013
  3. doi request reprint Fibromyalgia syndrome--novel therapeutic targets
    Jacob N Ablin
    Institute of Rheumatology, Tel Aviv Sourasky Medical Center and Tel Aviv University, Faculty of Medicine, Tel Aviv, Israel
    Maturitas 75:335-40. 2013
  4. ncbi request reprint Prevalence of fibromyalgia in the Israeli population: a population-based study to estimate the prevalence of fibromyalgia in the Israeli population using the London Fibromyalgia Epidemiology Study Screening Questionnaire (LFESSQ)
    Jacob N Ablin
    Department of Rheumatology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
    Clin Exp Rheumatol 30:39-43. 2012
  5. doi request reprint Personalized treatment of pain
    Jacob N Ablin
    Institute of Rheumatology, Tel Aviv Sourasky Medical Center and Sackler Faculty of Medicine, Tel Aviv University, 6 Weizmann Street, Tel Aviv 64239, Israel
    Curr Rheumatol Rep 15:298. 2013
  6. pmc Evaluation of leptin levels among fibromyalgia patients before and after three months of treatment, in comparison with healthy controls
    Jacob Nadav Ablin
    Department of Rheumatology, Tel Aviv Sourasky Medical Center, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
    Pain Res Manag 17:89-92. 2012
  7. ncbi request reprint Sexual dysfunction is correlated with tenderness in female fibromyalgia patients
    J N Ablin
    Rheumatology Institute, Tel Aviv Sourasky Medical Center, Israel
    Clin Exp Rheumatol 29:S44-8. 2011
  8. doi request reprint The Hebrew version of the FibroFatigue scale: validation of a questionnaire for assessment of fibromyalgia and chronic fatigue syndrome
    Jacob N Ablin
    Institute of Rheumatology and Internal Medicine 6, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
    Rheumatol Int 30:1173-6. 2010
  9. doi request reprint Association between fibromyalgia and coronary heart disease and coronary catheterization
    Jacob N Ablin
    Department of Internal Medicine 6, Tel Aviv Sourasky Medical Center, affiliated with the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    Clin Cardiol 32:E7-11. 2009
  10. ncbi request reprint Effect of anti-TNFalpha treatment on circulating endothelial progenitor cells (EPCs) in rheumatoid arthritis
    Jacob N Ablin
    Department of Rheumatology, Tel Aviv Sourasky Medical Center and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    Life Sci 79:2364-9. 2006

Collaborators

Detail Information

Publications82

  1. doi request reprint Pathogenesis of fibromyalgia - a review
    Jacob Ablin
    Department of Rheumatology, Institute of Rheumatology, Tel Aviv Sourasky Medical Center and Sackler Faculty of Medicine, 6 Weizman St, Tel Aviv University, Tel Aviv 64239, Israel
    Joint Bone Spine 75:273-9. 2008
    ....
  2. ncbi request reprint Effects of sleep restriction and exercise deprivation on somatic symptoms and mood in healthy adults
    Jacob N Ablin
    Institute of Rheumatology, Sourasky Medical Center, and Tel Aviv University faculty of Medicine, Israel
    Clin Exp Rheumatol 31:S53-9. 2013
    ....
  3. doi request reprint Fibromyalgia syndrome--novel therapeutic targets
    Jacob N Ablin
    Institute of Rheumatology, Tel Aviv Sourasky Medical Center and Tel Aviv University, Faculty of Medicine, Tel Aviv, Israel
    Maturitas 75:335-40. 2013
    ..In the current review, current and emerging therapeutic options for the syndrome of fibromyalgia are covered. ..
  4. ncbi request reprint Prevalence of fibromyalgia in the Israeli population: a population-based study to estimate the prevalence of fibromyalgia in the Israeli population using the London Fibromyalgia Epidemiology Study Screening Questionnaire (LFESSQ)
    Jacob N Ablin
    Department of Rheumatology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
    Clin Exp Rheumatol 30:39-43. 2012
    ..We have attempted to estimate the prevalence of fibromyalgia in the Israeli population, using the London Fibromyalgia Epidemiology Study Screening Questionnaire (LFESSQ), an instrument previously utilised in several European countries...
  5. doi request reprint Personalized treatment of pain
    Jacob N Ablin
    Institute of Rheumatology, Tel Aviv Sourasky Medical Center and Sackler Faculty of Medicine, Tel Aviv University, 6 Weizmann Street, Tel Aviv 64239, Israel
    Curr Rheumatol Rep 15:298. 2013
    ..Last, listening to the patient and understanding the context in which pain has affected his or her life is an important part of maintaining the personal nature of therapeutic interaction with patients suffering from pain...
  6. pmc Evaluation of leptin levels among fibromyalgia patients before and after three months of treatment, in comparison with healthy controls
    Jacob Nadav Ablin
    Department of Rheumatology, Tel Aviv Sourasky Medical Center, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
    Pain Res Manag 17:89-92. 2012
    ..The pathogenesis involves a disturbance in pain processing and transmission by the central nervous system, leading to a general increase in pain perception...
  7. ncbi request reprint Sexual dysfunction is correlated with tenderness in female fibromyalgia patients
    J N Ablin
    Rheumatology Institute, Tel Aviv Sourasky Medical Center, Israel
    Clin Exp Rheumatol 29:S44-8. 2011
    ..The purpose of the current study was to evaluate sexual dysfunction among female fibromyalgia syndrome (FMS) patients...
  8. doi request reprint The Hebrew version of the FibroFatigue scale: validation of a questionnaire for assessment of fibromyalgia and chronic fatigue syndrome
    Jacob N Ablin
    Institute of Rheumatology and Internal Medicine 6, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
    Rheumatol Int 30:1173-6. 2010
    ..These results support the reliability and validity of the data obtained with the Hebrew version of the FSS for detecting and measuring symptom severity in Hebrew speaking patients with FM...
  9. doi request reprint Association between fibromyalgia and coronary heart disease and coronary catheterization
    Jacob N Ablin
    Department of Internal Medicine 6, Tel Aviv Sourasky Medical Center, affiliated with the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    Clin Cardiol 32:E7-11. 2009
    ..Both FM and ischemic heart disease have been linked with depression. The purpose of this study was to retrospectively investigate the frequency of FM symptoms and physical findings among patients undergoing coronary catheterization...
  10. ncbi request reprint Effect of anti-TNFalpha treatment on circulating endothelial progenitor cells (EPCs) in rheumatoid arthritis
    Jacob N Ablin
    Department of Rheumatology, Tel Aviv Sourasky Medical Center and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    Life Sci 79:2364-9. 2006
    ..Endothelial progenitor cells (EPCs) have the ability to differentiate into mature endothelium and have a potentially reparative role protecting against ischemia and atherosclerosis...
  11. ncbi request reprint Fibromyalgia, infection and vaccination: two more parts in the etiological puzzle
    Jacob N Ablin
    Department of Rheumatology, Tel Aviv Sourasky Medical Center and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    J Autoimmun 27:145-52. 2006
    ..Based on this example a model is proposed, wherein vaccinations function as co-triggers for the development of functional disorders including fibromyalgia, in conjunction with additional contributing factors...
  12. pmc Protective effect of eotaxin-2 inhibition in adjuvant-induced arthritis
    J N Ablin
    Sourasky Medical Center, Rheumatology Institute, Tel Aviv University, Tel Aviv, Israel
    Clin Exp Immunol 161:276-83. 2010
    ..Inhibition of eotaxin-2 by monoclonal antibodies has a significant protective effect in adjuvant arthritis. These results may introduce a novel therapeutic target in rheumatoid arthritis and additional inflammatory joint disorders...
  13. ncbi request reprint Mechanisms of Disease: genetics of fibromyalgia
    Jacob N Ablin
    Department of Rheumatology, Tel Aviv Sourasky Medical Center, Tel Aviv University, 6 Weizman Street, Tel Aviv 64239, Israel
    Nat Clin Pract Rheumatol 2:671-8. 2006
    ....
  14. ncbi request reprint A tale of two cities - the effect of low intensity conflict on prevalence and characteristics of musculoskeletal pain and somatic symptoms associated with chronic stress
    J N Ablin
    Tel Aviv Sourasky Medical Center, Institute of Rheumatology and Tel Aviv University, Tel Aviv, Israel
    Clin Exp Rheumatol 28:S15-21. 2010
    ..Ofakim, a town of similar demographic and socioeconomic characteristics, had not been targeted, as of the period of our study. We examined the occurrence and characteristics of pain and related somatic symptoms in Sderot and Ofakim...
  15. ncbi request reprint Treatment of Machado-Joseph disease with trimethoprim-sulphamethoxazole following successful desensitisation
    Jacob Ablin
    Department of Rheumatology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
    N Z Med J 117:U819. 2004
  16. ncbi request reprint Holocaust survivors: the pain behind the agony. Increased prevalence of fibromyalgia among Holocaust survivors
    J N Ablin
    Institute of Rheumatology, Tel Aviv Sourasky Medical Centre, Israel
    Clin Exp Rheumatol 28:S51-6. 2010
    ....
  17. ncbi request reprint Coping styles in fibromyalgia: effect of co-morbid posttraumatic stress disorder
    Jacob N Ablin
    Institute of Rheumatology, Tel Aviv Sourasky Medical Center and Sackler Faculty of Medicine, Tel Aviv University, 6 Weizman St, Tel Aviv 64239, Israel
    Rheumatol Int 28:649-56. 2008
    ..Our results may serve to further characterize cognitive and behavioral aspects of FM patients and subsequently guide therapeutic interventions...
  18. doi request reprint The Ras antagonist farnesylthiosalicylic acid ameliorates experimental myocarditis in the rat
    Rakefet Pando
    Department of Cardiology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
    Cardiovasc Pathol 19:94-101. 2010
    ..We thus hypothesized that S-farnesylthiosalicylic acid (FTS), a synthetic small molecule that detaches Ras from the inner cell membrane and induces its rapid degradation, will attenuate experimental autoimmune myocarditis (EAM)...
  19. ncbi request reprint Functional inhibition of Ras by S-trans,trans-farnesyl thiosalicylic acid attenuates atherosclerosis in apolipoprotein E knockout mice
    Jacob George
    Department of Cardiology and the Cardiovascular Research Laboratory, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
    Circulation 105:2416-22. 2002
    ..The processes that are involved in atherosclerosis would likely require intact Ras pathways, which play a key role in the control of cell growth, differentiation, and apoptosis...
  20. pmc Circulating endothelial progenitor cells and clinical outcome in patients with congestive heart failure
    Yoav Michowitz
    The Department of Cardiology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
    Heart 93:1046-50. 2007
    ..EPC levels were also shown to predict outcome in patients with atherosclerotic vascular disease. We tested the hypothesis that circulating EPC can predict outcome in patients with congestive heart failure (CHF)...
  21. doi request reprint B-type natriuretic peptide enhances vasculogenesis by promoting number and functional properties of early endothelial progenitor cells
    Haim Shmilovich
    Department of Cardiology, Tel Aviv Sourasky Medical Center, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
    Tissue Eng Part A 15:2741-9. 2009
    ..To test the hypothesis that B-type natriuretic peptide (BNP) acts as a potent vasculogenic agent by enhancing the number, proliferation, adhesion, and migration of endothelial progenitor cells (EPCs)...
  22. doi request reprint N-Ras or K-Ras inhibition increases the number and enhances the function of Foxp3 regulatory T cells
    Adi Mor
    Cardiovascular Research Center, Department of Cardiology, Tel Aviv Sourasky Medical Center, affiliated with the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    Eur J Immunol 38:1493-502. 2008
    ..Thus, inhibition of the N- or K-Ras isoform triggers an anti-inflammatory effect by up-regulating, via Foxp3 elevation, the numbers and functional suppressive properties of Treg...
  23. ncbi request reprint A functional role for inducible costimulator (ICOS) in atherosclerosis
    Arnon Afek
    Department of Cardiology and the Cardiovascular Research Laboratory, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, 6 Weizmann St, Tel Aviv, Israel
    Atherosclerosis 183:57-63. 2005
    ..Inducible costimulator (ICOS) is a newly discovered T cell molecule with a dual role in immune mediated disorders. Herein, we tested the importance of ICOS in atherosclerosis...
  24. doi request reprint Normal levels and function of endothelial progenitor cells in patients with psoriatic arthritis
    Jacob N Ablin
    The Department of Rheumatology, Rheumatology Institute, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
    Rheumatol Int 29:257-62. 2009
    ..A significant correlation was found between levels of VGEF and the BASDAI score. The results of the current study do not support a significant role for EPCs in the pathogenesis of psoriasis and psoriatic arthritis...
  25. doi request reprint Clopidogrel attenuates atheroma formation and induces a stable plaque phenotype in apolipoprotein E knockout mice
    Arnon Afek
    The Department of Cardiology, Tel Aviv Sourasky Medical Center, Tel Aviv University, Sackler School of Medicine, Tel Aviv, Israel
    Microvasc Res 77:364-9. 2009
    ..Herein, we tested the hypothesis that clopidogrel will influence plaque size and composition in the atherosclerosis prone apolipoprotein E knockout (apoE KO) mouse model...
  26. ncbi request reprint Predictive value of high sensitivity CRP in patients with diastolic heart failure
    Yoav Michowitz
    The Department of Cardiology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
    Int J Cardiol 125:347-51. 2008
    ..However, the role of C-reactive protein (CRP) in patients with diastolic HF is not established. We studied the predictive role of high sensitivity CRP (hsCRP) in patients with diastolic HF...
  27. doi request reprint Antibodies to oxidized LDL as predictors of morbidity and mortality in patients with chronic heart failure
    Gideon Charach
    Department of Cardiology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
    J Card Fail 15:770-4. 2009
    ..Ox LDL Abs have been shown to correlate with clinical control in HF patients. We evaluated the predictive power of Ox LDL Abs on the outcome in patients with HF...
  28. doi request reprint Ras inhibition attenuates myocardial ischemia-reperfusion injury
    Rakefet Pando
    The Department of Cardiology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
    Biochem Pharmacol 77:1593-601. 2009
    ..3+/-2.5% vs. 36+/-7% compared with control I/R rats (in vivo) p<0.05. These effects may be associated with the down regulation of JNK as a short-term effector and with Mst-1 in the long-term remodeling process...
  29. ncbi request reprint Evidence for the involvement of T cell costimulation through the B-7/CD28 pathway in atherosclerotic plaques from apolipoprotein E knockout mice
    Arnon Afek
    The Institute of Pathology, Sheba Medical Center, Tel Aviv, Israel
    Exp Mol Pathol 76:219-23. 2004
    ..These results suggest that primary T cell activation may assume a functional proinflammatory program within the plaque by involvement of CD28/B7 costimulatory pathway...
  30. ncbi request reprint Safety and efficacy of vaccination against streptococcus pneumonia in patients with rheumatic diseases
    Ori Elkayam
    Department of Rheumatology, Tel Aviv Medical Center and the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    Autoimmun Rev 6:312-4. 2007
    ..Several trials have shown that the vaccine does not induce clinical exacerbation of RA and that it does induce an adequate humoral response, albeit one lower than that in healthy controls...
  31. ncbi request reprint Usefulness of serum myeloperoxidase in prediction of mortality in patients with severe heart failure
    Yoav Michowitz
    Department of Cardiology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
    Isr Med Assoc J 10:884-8. 2008
    ..Myeloperoxidase levels were shown to reflect endothelial dysfunction, inflammation, atherosclerosis and oxidative stress...
  32. doi request reprint Whole-body hyperthermia attenuates experimental autoimmune myocarditis in the rat
    Alon Barsheshet
    Cardiovascular Research Center, Tel Aviv Sourasky Medical Center affiliated to the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    Cardiovasc Pathol 17:375-81. 2008
    ..We evaluated the effects of whole-body hyperthermia (WBH) on experimental autoimmune myocarditis (EAM) induced either by injection of myosin or by adoptive transfer of lymphocytes...
  33. doi request reprint A potential role for islet-1 in post-natal angiogenesis and vasculogenesis
    Aya Barzelay
    Cardiovascular Research Center, The Department of Cardiology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
    Thromb Haemost 103:188-97. 2010
    ..These data suggest, for the first time, that Isl1 promotes postnatal angiogenesis and vasculogenesis by improving the angiogenic properties of endothelial cells and MSCs...
  34. pmc Circulating apoptotic progenitor cells in patients with congestive heart failure
    Dael Geft
    Department of Cardiology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
    PLoS ONE 3:e3238. 2008
    ..We sought to quantify the numbers of apoptotic progenitors in patients with congestive heart failure...
  35. doi request reprint Constitutive expression of HIF-1alpha and HIF-2alpha in bone marrow stromal cells differentially promotes their proangiogenic properties
    Jeremy Ben-Shoshan
    Department of Cardiology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
    Stem Cells 26:2634-43. 2008
    ..Our results support the use of HIF-alpha genes, particularly HIF-2alpha, to augment the efficacy of future cell-based therapy. Disclosure of potential conflicts of interest is found at the end of this article...
  36. ncbi request reprint Serum levels of interleukin-18 in patients with stable and unstable angina pectoris
    Rafael Rosso
    Department of Cardiology, Tel Aviv Sourasky Medical Center, Tel Aviv University, Tel Aviv, Israel
    Int J Cardiol 98:45-8. 2005
    ..Although IL-18 serum levels appear elevated in the presence of coronary atherosclerosis, there is no evidence to associate this progression towards plaque instability...
  37. ncbi request reprint Circulating apoptotic progenitor cells: a novel biomarker in patients with acute coronary syndromes
    Shmuel Schwartzenberg
    Tel Aviv University, Sackler School of Medicine, Tel Aviv, Israel
    Arterioscler Thromb Vasc Biol 27:e27-31. 2007
    ..We tested the hypothesis that circulating apoptotic progenitors are detectable in healthy subjects and altered in ACS patients...
  38. ncbi request reprint Zinc reduces intimal hyperplasia in the rat carotid injury model
    Michael Berger
    The Cardiovascular Research Laboratory, The Department of Cardiology, Elias Sourasky, Tel Aviv Medical Center, Tel Aviv University Sackler Faculty of Medicine, 6 Weizmann St, Tel Aviv, Israel
    Atherosclerosis 175:229-34. 2004
    ..Interestingly, it has been shown to have anti-inflammatory and anti-proliferative properties. We thus sought to investigate its effect on smooth muscle cell proliferation and intimal thickening in the rat carotid artery injury model...
  39. doi request reprint Influence of non-toxic doses of bevacizumab and ranibizumab on endothelial functions and inhibition of angiogenesis
    Aya Barzelay
    Tel Aviv Medical Center, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
    Curr Eye Res 35:835-41. 2010
    ..The purpose of this study was to compare the influence of Bevacizumab and Ranibizumab on angiogenesis in an in vitro model...
  40. doi request reprint Mechanisms of disease: the evolving role of regulatory T cells in atherosclerosis
    Jacob George
    Department of Cardiology and the Cardiovascular Research Center, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Israel
    Nat Clin Pract Cardiovasc Med 5:531-40. 2008
    ..The growing knowledge of the role of regulatory T cells could result in the future development of novel therapeutic modalities to attenuate atherosclerosis and stabilize vulnerable plaques...
  41. ncbi request reprint L-arginine attenuates lymphocyte activation and anti-oxidized LDL antibody levels in patients undergoing angioplasty
    Jacob George
    The Department of Cardiology, Tel Aviv Medical Center affiliated to the Sackler Faculty of Medicine, 6 Weizman Street, Tel Aviv University, Tel Aviv, Israel
    Atherosclerosis 174:323-7. 2004
    ..We sought to investigate the effect of L-arginine administration on the extent of lymphocyte activation and anti-oxLDL antibodies in patients with unstable angina undergoing PCI with stent placement...
  42. ncbi request reprint Role of naturally occurring CD4+ CD25+ regulatory T cells in experimental atherosclerosis
    Adi Mor
    Department of Cardiology, Tel Aviv Sourasky Medical Center, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
    Arterioscler Thromb Vasc Biol 27:893-900. 2007
    ..We investigated the importance and potential role of Tregs in murine atherogenesis...
  43. ncbi request reprint Functional T-lymphocyte dichotomy in the peripheral blood of patients with unstable angina
    Arnon Adler
    The Department of Cardiology, Tel Aviv Souraski Medical Center, Tel Aviv, Israel
    Int J Cardiovasc Intervent 7:146-51. 2005
    ..Herein, we investigated the percentage of T-helper (Th1) and Th2 cells among the general T-cell population in the peripheral blood of patients with stable angina (SA) and unstable angina (UA)...
  44. ncbi request reprint Transfer of endothelial progenitor and bone marrow cells influences atherosclerotic plaque size and composition in apolipoprotein E knockout mice
    Jacob George
    Department of Cardiology, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Israel
    Arterioscler Thromb Vasc Biol 25:2636-41. 2005
    ..We explored the effect of BM cell- or spleen cell-derived EPC transfer on plaque size and stability markers in the apolipoprotein E knockout (apoE KO) mouse model...
  45. ncbi request reprint Circulating matrix metalloproteinase-2 but not matrix metalloproteinase-3, matrix metalloproteinase-9, or tissue inhibitor of metalloproteinase-1 predicts outcome in patients with congestive heart failure
    Jacob George
    Department of Cardiology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
    Am Heart J 150:484-7. 2005
    ..Herein we evaluated the potential significance of circulating MMP and TIMP levels in patients with congestive HF (CHF) speculating it may assume prognostic value...
  46. ncbi request reprint Number and adhesive properties of circulating endothelial progenitor cells in patients with in-stent restenosis
    Jacob George
    The Department of Cardiology, Tel Aviv Sourasky Medical Center, The Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    Arterioscler Thromb Vasc Biol 23:e57-60. 2003
    ..We reasoned that robust in-stent intimal growth could be partially related to impaired endothelialization resulting from reduced circulating EPC number or function...
  47. ncbi request reprint Suppression of myosin-induced and adoptively transferred myocarditis by prior treatment with complete Freund's adjuvant
    Jacob George
    Department of Cardiology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
    Cardiovasc Pathol 13:221-4. 2004
    ..We evaluated the effect of pretreatment with complete Freund's adjuvant (CFA) on experimentally induced myocarditis concomitant with the assessment of antigen-specific properties of disease-triggering lymphocytes...
  48. ncbi request reprint Eptifibatide does not influence lymphocyte activation and CRP levels in patients with undergoing coronary angioplasty
    Ariel Finkelstein
    The Department of Cardiology, Tel Aviv Sourasky Medical Center, Israel
    Int J Cardiovasc Intervent 6:107-9. 2004
    ..These results may explain the differences in clinical outcome following PCI by use of different IIB-IIIA agents...
  49. ncbi request reprint The involvement of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) in atherosclerosis
    Yoav Michowitz
    Department of Cardiology, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    J Am Coll Cardiol 45:1018-24. 2005
    ..Herein, we determined the significance of tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) in atherosclerotic vascular disease...
  50. ncbi request reprint Usefulness of anti-oxidized LDL antibody determination for assessment of clinical control in patients with heart failure
    Jacob George
    The Department of Cardiology, Tel Aviv Sourasky Medical Center, Israel The Sackler Faculty of Medicine, Tel Aviv University, Israel
    Eur J Heart Fail 8:58-62. 2006
    ..Therefore, we tested the hypothesis that anti-oxLDL antibodies correlate with the control of heart failure (HF), as manifested by hospital admissions for cardiac dysfunction...
  51. ncbi request reprint Erythropoietin promotes endothelial progenitor cell proliferative and adhesive properties in a PI 3-kinase-dependent manner
    Jacob George
    The Department of Cardiology, Tel Aviv Sourasky Medical Center, Tel Aviv University, Israel
    Cardiovasc Res 68:299-306. 2005
    ..We explored the effect of chronic treatment with Epo on the numbers and functional properties of EPC in CHF patients...
  52. ncbi request reprint Cellular autoimmunity to cardiac myosin in patients with a recent myocardial infarction
    Miriam Moraru
    Department of Cardiology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
    Int J Cardiol 107:61-6. 2006
    ..Thus, in patients with a recent history of MI, cellular autoimmunity to cardiac myosin is present as compared with controls. It remains to be determined whether this autoimmune response is associated with an adverse outcome...
  53. ncbi request reprint Circulating endothelial progenitor cells in patients with unstable angina: association with systemic inflammation
    Jacob George
    The Department of Cardiology and the Haematology Institute, Tel Aviv Sourasky Medical Center and the Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
    Eur Heart J 25:1003-8. 2004
    ..We investigated the number and adhesive properties of EPCs from patients with unstable angina and no evidence of cardiac necrosis...
  54. ncbi request reprint Suppression of early atherosclerosis in LDL-receptor deficient mice by oral tolerance with beta 2-glycoprotein I
    Jacob George
    Department of Cardiology, Tel Aviv Medical Center, Israel
    Cardiovasc Res 62:603-9. 2004
    ..Herein, we tested the hypothesis, that inhibiting cellular immunity to beta 2GPI would result in suppression of fatty streak formation in mice...
  55. pmc Circulating endothelial progenitor cells in patients with cardiac syndrome X
    Haim Shmilovich
    Department of Cardiology, Tel Aviv Sourasky Medical Centre, Tel Aviv, Israel
    Heart 93:1071-6. 2007
    ..Endothelial progenitor cells (EPCs) in the peripheral circulation contribute to tissue vascularisation...
  56. ncbi request reprint Oral tolerance with heat shock protein 65 attenuates Mycobacterium tuberculosis-induced and high-fat-diet-driven atherosclerotic lesions
    Dror Harats
    Institute of Lipid and Atherosclerosis Research, Sheba Medical Center, Tel Hashomer, Israel
    J Am Coll Cardiol 40:1333-8. 2002
    ..The goal of this study was to explore the efficacy of oral tolerance with heat shock protein (HSP) 65 in two apparently non-overlapping models of murine atherosclerosis...
  57. ncbi request reprint Immunity to heat shock protein 65--an additional determinant in intimal thickening
    Jacob George
    Cardiovascular Research Laboratory, Department of Cardiology, Tel Aviv Sourasky Medical Center, Tel Aviv University Sackler School of Medicine, 6 Weizman St, Israel
    Atherosclerosis 168:33-8. 2003
    ..These results should be further investigated in humans as they may provide a possible link between infections and restenosis/accelerated arteriosclerosis...
  58. ncbi request reprint Tyrphostin AG-556 reduces myocardial infarct size and improves cardiac performance in the rat
    Jacob George
    Department of Cardiology and the Cardiovascular Research Laboratory, Tel Aviv Medical Center, Tel Aviv, Israel
    Exp Mol Pathol 74:314-8. 2003
    ..AG-556 has proven beneficial in reducing myocardial infarct size and attenuated consequent hemodynamic deterioration in the rat model. If reconfirmed, AG-556 may be of potential clinical use in post-MI patients...
  59. ncbi request reprint Circulating erythropoietin levels and prognosis in patients with congestive heart failure: comparison with neurohormonal and inflammatory markers
    Jacob George
    Department of Cardiology, Tel Aviv Sourasky Medical Center, and Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
    Arch Intern Med 165:1304-9. 2005
    ..We prospectively evaluated the predictive value of baseline EPO, N-terminal pro-B-type natriuretic peptide, and C-reactive protein levels in patients with clinically controlled chronic CHF...
  60. ncbi request reprint The effect of tyrphostin AG-556 on intimal thickening in a mouse model of arterial injury
    Jacob George
    Department of Cardiology, Tel Aviv Sourasky Medical Center, affiliated to the Sackler Faculty of Medicine, 6 Weizman Street, Tel Aviv University, Israel
    Exp Mol Pathol 78:233-8. 2005
    ..In the current study, we investigated the effect of the tyrphostin AG-556 on neointimal thickening and cytokine profile in a model of arterial injury in the mouse...
  61. ncbi request reprint Inhibition of intimal thickening in the rat carotid artery injury model by a nontoxic Ras inhibitor
    Jacob George
    Department of Cardiology and the Cardiovascular Research Laboratory, Tel Aviv Sourasky Medical Center, Tel Aviv University, Sackler School of Medicine, Israel
    Arterioscler Thromb Vasc Biol 24:363-8. 2004
    ..In the present study, we tested the hypothesis that systemic administration of FTS will suppress intimal thickening in the rat carotid injury model...
  62. ncbi request reprint Neurohormonal and inflammatory markers as predictors of short-term outcome in patients with heart failure and cardiac resynchronization therapy
    Aharon Glick
    Department of Cardiology, Tel Aviv Sourasky Medical Center, Israel
    Isr Med Assoc J 8:391-5. 2006
    ..Nevertheless, not all patients respond favorably to CRT. Natriuretic peptides and inflammatory markers are elevated in congestive heart failure and reflect disease severity...
  63. ncbi request reprint The effect of early and late treatment with the tyrphostin AG-556 on the progression of experimental autoimmune myocarditis
    Jacob George
    Department of Cardiology and the Cardiovascular Research Laboratory, Tel Aviv Medical Center, Tel Aviv University, Sackler School of Medicine, Tel Aviv, Israel
    Exp Mol Pathol 76:234-41. 2004
    ..Thus, AG-556 may represent a novel strategy of ameliorating the progression of myocarditis without non-selectively compromising the immune system...
  64. ncbi request reprint Comparative analysis of methods for assessment of circulating endothelial progenitor cells
    Jacob George
    The Department of Cardiology, Tel Aviv University, Israel
    Tissue Eng 12:331-5. 2006
    ..These findings may suggest that CD34/KDR is more appropriate for the definition of circulating EPC, whereas CFU numbers are more likely to reflect their ability to proliferate...
  65. ncbi request reprint Temporal association between circulating proteolytic, inflammatory and neurohormonal markers in patients with coronary ectasia
    Ariel Finkelstein
    The Department of Cardiology, Tel Aviv Sourasky Medical Center, 6 Weizmann Street, Tel Aviv, Israel
    Atherosclerosis 179:353-9. 2005
    ..We also evaluated the association of MMP with inflammatory or the neurohormonal markers...
  66. ncbi request reprint Serum levels of anti heat shock protein 70 antibodies in patients with stable and unstable angina pectoris
    Itzhak Herz
    The Department of Cardiology, Tel Aviv Sourasky Medical Center and the Sackler Faculty of Medicine, Tel Aviv University, Israel
    Acute Card Care 8:46-50. 2006
    ..In this retrospective, case control study, we investigated whether patients with established atherosclerosis, with either stable or unstable angina have high levels of antibodies to HSP70...
  67. ncbi request reprint Stent thrombosis in patients treated with thienopyridines: clinical description of 10 cases
    Yoav Michowitz
    Tel Aviv Sourasky Medical Center, Israel
    Int J Cardiovasc Intervent 6:160-4. 2004
    ..Prospective studies should be performed to elucidate drug interactions that may reduce clopidogrel efficacy and contribute to stent thrombosis...
  68. ncbi request reprint Erythropoietin improves myocardial performance in doxorubicin-induced cardiomyopathy
    Saher Hamed
    Department of Cardiology, Tel Aviv Sourasky Medical Center, The Sackler Faculty of Medicine, Tel Aviv University, Israel
    Eur Heart J 27:1876-83. 2006
    ..We tested the hypothesis that EPC are compromised in rats with Dox-induced cardiotoxicity and correction of this functional impairment by treatment with Epo could result in attenuation of myocardial dysfunction...
  69. ncbi request reprint Large aorta and narrow arteries: two short stories of too long diagnostic delay
    Doron Boltin
    Department of Internal Medicine F, Tel Aviv Medical Center and the Sackler Faculty of Medicine, Tel Aviv University, 6 Weizman Street, 64239 Tel Aviv, Israel
    Rheumatol Int 27:985-7. 2007
    ....
  70. ncbi request reprint An unlikely cause of anemia and abdominal pain
    Tatiana Levit
    Department of Internal Medicine F, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
    Isr Med Assoc J 9:408-9. 2007
  71. doi request reprint Ras inhibition increases the frequency and function of regulatory T cells and attenuates type-1 diabetes in non-obese diabetic mice
    Adi Mor
    Department of Neurobiology, George S Wise Faculty of Life Sciences, Tel Aviv University, Israel
    Eur J Pharmacol 616:301-5. 2009
    ..Ras inhibition might therefore be worth developing as a new treatment modality in patients with type 1 diabetes...
  72. ncbi request reprint [The role of cytokines secreted by T cells in the pathogenesis of angina pectoris]
    Arnon Adler
    Department of Cardiology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
    Harefuah 142:612-5, 645. 2003
    ..Interleukin 10 diminishes the secretion of interferon-gamma, inhibits the secretion of enzymes which destroy connective tissue in the atheromatous lesion and interferes with clot formation on the unstable lesion...
  73. doi request reprint Ras inhibition attenuates pancreatic cell death and experimental type 1 diabetes: possible role of regulatory T cells
    Elizabeta Aizman
    Department of Neurobiology, George S Wise Faculty of Life Sciences, Tel Aviv University, 69978 Tel Aviv, Israel
    Eur J Pharmacol 643:139-44. 2010
    ..It thus appears that F-FTS induces Treg to play a protective role in the progression of experimental type-1 diabetes, suggesting that these cells represent a potential target for the treatment of this disorder...
  74. ncbi request reprint Endothelial progenitor cells as therapeutic vectors in cardiovascular disorders: from experimental models to human trials
    Jeremy Ben-Shoshan
    Department of Cardiology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
    Pharmacol Ther 115:25-36. 2007
    ..Here, we review the experimental data that has accumulated so far from animal and clinical studies regarding the potential importance of EPCs. In addition, we discuss the potential hurdles as well as future options of EPC-based therapy...
  75. ncbi request reprint The role of erythropoietin in myocardial protection: potential mechanisms and applications
    Shmuel Schwartzenberg
    Department of Cardiology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
    Expert Rev Cardiovasc Ther 4:41-50. 2006
    ..The purpose of this review is to summarize the pleiotropic cardioprotective effects of erythropoietin in the cardiovascular system and to evaluate its potential role as a biomarker in these disorders...
  76. doi request reprint Hypoxia-inducible factor-1alpha and -2alpha additively promote endothelial vasculogenic properties
    Jeremy Ben-Shoshan
    Department of Cardiology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
    J Vasc Res 46:299-310. 2009
    ..We studied the discrete and common effects of HIF-1alpha and HIF-2alpha on the cytokine expression and vasculogenic properties of ECs...
  77. doi request reprint HIF-1alpha overexpression and experimental murine atherosclerosis
    Jeremy Ben-Shoshan
    Department of Cardiology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
    Arterioscler Thromb Vasc Biol 29:665-70. 2009
    ..We studied the effects of overexpression of HIF-1alpha in ApoE knockout murine lymphocytes, on experimental atherosclerosis...
  78. doi request reprint Tocilizumab in Adult-onset Still's Disease: the Israeli Experience
    Ori Elkayam
    From the Department of Rheumatology, Tel Aviv Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv Department of Rheumatology, Bnai Zion Medical Center, Haifa Department of Medicine, Hadassah Hebrew University Medical Center, Jerusalem Rheumatology Unit, The Chaim Sheba Medical Center, Tel Hashomer Rheumatology Unit, Assaf Harofe Medical Center Rheumatology Unit, Soroka Medical Center, Beer Sheva, Israel
    J Rheumatol 41:244-7. 2014
    ..To describe the Israeli experience of treating adult-onset Still's disease (AOSD) with tocilizumab (TCZ)...
  79. doi request reprint Antiphospholipid antibodies from a patient with primary antiphospholipid syndrome enhance experimental atherosclerosis
    Arnon Adler
    Department of Cardiology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
    Nat Clin Pract Cardiovasc Med 6:215-8. 2009
    ..A 35-year-old man with primary antiphospholipid syndrome and no risk factors for atherosclerosis presented with postinfarction angina...
  80. doi request reprint Baseline low-density lipoprotein cholesterol levels and outcome in patients with heart failure
    Gideon Charach
    Department of Internal Medicine, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
    Am J Cardiol 105:100-4. 2010
    ....
  81. ncbi request reprint Autoantibodies to cardiac troponin I in patients with idiopathic dilated and ischemic cardiomyopathy
    Haim Shmilovich
    The Department of Cardiology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
    Int J Cardiol 117:198-203. 2007
    ..Herein, we studied the presence and functional properties of autoantibodies to cTpnI in patients with idiopathic dilated cardiomyopathy (DCM) and ischemic cardiomyopathy (ICM)...
  82. ncbi request reprint Altered status of CD4(+)CD25(+) regulatory T cells in patients with acute coronary syndromes
    Adi Mor
    Department of Cardiology, Tel Aviv Sourasky Medical Center, Tel Aviv University, Sackler School of Medicine, Tel Aviv 64239, Israel
    Eur Heart J 27:2530-7. 2006
    ..We have hypothesized that peripheral numbers and function of Tregs would be deranged in patients with acute coronary syndromes (ACS)...