Herman Wolosker

Summary

Affiliation: Technion-Israel Institute of Technology
Country: Israel

Publications

  1. ncbi request reprint D-serine regulation of NMDA receptor activity
    Herman Wolosker
    Department of Biochemistry, B Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa 31096, Israel
    Sci STKE 2006:pe41. 2006
  2. doi request reprint Serine racemase: an unconventional enzyme for an unconventional transmitter
    Herman Wolosker
    Department of Biochemistry, B Rappaport Faculty of Medicine, Technion Israel Institute of Technology, 31096, Haifa, Israel
    Amino Acids 43:1895-904. 2012
  3. doi request reprint Serine racemase and the serine shuttle between neurons and astrocytes
    Herman Wolosker
    Department of Biochemistry, B Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa 31096, Israel
    Biochim Biophys Acta 1814:1558-66. 2011
  4. ncbi request reprint Neurobiology through the looking-glass: D-serine as a new glial-derived transmitter
    Herman Wolosker
    Department of Biochemistry, B Rappaport Faculty of Medicine, Technion Israel Institute of Technology, P O Box 9649, Bat Galim, 31096, Haifa, Israel
    Neurochem Int 41:327-32. 2002
  5. doi request reprint D-amino acids in the brain: D-serine in neurotransmission and neurodegeneration
    Herman Wolosker
    Department of Biochemistry, B Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    FEBS J 275:3514-26. 2008
  6. ncbi request reprint NMDA receptor regulation by D-serine: new findings and perspectives
    Herman Wolosker
    Department of Biochemistry, B Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa, 31096, Israel
    Mol Neurobiol 36:152-64. 2007
  7. ncbi request reprint Modulation of D-serine levels via ubiquitin-dependent proteasomal degradation of serine racemase
    Elena Dumin
    Department of Biochemistry, The Bruce Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa 31096, Israel
    J Biol Chem 281:20291-302. 2006
  8. doi request reprint Neuronal D-serine and glycine release via the Asc-1 transporter regulates NMDA receptor-dependent synaptic activity
    Dina Rosenberg
    Department of Biochemistry, The Rappaport Faculty of Medicine and Research Institute, Technion Israel Institute of Technology, Haifa 31096, Israel
    J Neurosci 33:3533-44. 2013
  9. ncbi request reprint Neuron-derived D-serine release provides a novel means to activate N-methyl-D-aspartate receptors
    Elena Kartvelishvily
    Department of Biochemistry, Bruce Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa 31096, Israel
    J Biol Chem 281:14151-62. 2006
  10. doi request reprint D-serine: physiology and pathology
    Inna Radzishevsky
    Department of Biochemistry, B Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    Curr Opin Clin Nutr Metab Care 16:72-5. 2013

Collaborators

  • Rogerio Panizzutti
  • Simone Engelender
  • Hisashi Mori
  • Jean Marie Billard
  • Akio Kihara
  • Galila Agam
  • Robert F Miller
  • Eric C Gustafson
  • Veronika N Foltyn
  • Inna Radzishevsky
  • Elena Kartvelishvily
  • Dina Rosenberg
  • Elena Dumin
  • Maria Shleper
  • Livia Balan
  • Joari De Miranda
  • Inna Bendikov
  • Joseph Haskin
  • Elena Dikopoltsev
  • Raymonde Szargel
  • Vered Shani
  • Ruth Rott
  • Martin Zehl
  • Ole N Jensen
  • Caroline Madeira
  • Seth M Dixon
  • Michael D Toney
  • Pu Li
  • Cátia S Ribeiro
  • Grace G Y Lim
  • Samar Artoul
  • Ran Inoue
  • Hagit Sason
  • Adi C Segal
  • Goren Kolodney
  • Rina Bandopadhyay
  • Kah Leong Lim
  • Lucy N Mekies
  • Chanda M C Klinker
  • Michael T Bowser
  • Inna S Radzishevsky
  • Diana Knoh
  • Yusuke Ohno
  • Allon Eyal
  • Maria Eliza Freitas
  • Charles Vargas-Lopes
  • Carmit Nadri
  • Shirly Amar
  • Mark J Kurth
  • Yoshio Misumi
  • Kit S Lam
  • Yukio Ikehara
  • Ruiwu Liu
  • Marcelo Reis

Detail Information

Publications25

  1. ncbi request reprint D-serine regulation of NMDA receptor activity
    Herman Wolosker
    Department of Biochemistry, B Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa 31096, Israel
    Sci STKE 2006:pe41. 2006
    ..Here, we discuss these new findings, which begin to shed light on the relative roles of glia and neurons in D-serine signaling...
  2. doi request reprint Serine racemase: an unconventional enzyme for an unconventional transmitter
    Herman Wolosker
    Department of Biochemistry, B Rappaport Faculty of Medicine, Technion Israel Institute of Technology, 31096, Haifa, Israel
    Amino Acids 43:1895-904. 2012
    ..Here, we review the mechanisms of D-serine synthesis by serine racemase and discuss the lessons we can learn from serine racemase knockout mice, focusing on the roles attributed to D-serine and its cellular origin...
  3. doi request reprint Serine racemase and the serine shuttle between neurons and astrocytes
    Herman Wolosker
    Department of Biochemistry, B Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa 31096, Israel
    Biochim Biophys Acta 1814:1558-66. 2011
    ..SR and the serine shuttle pathway are therapeutic targets in neurodegenerative diseases in which NMDA receptor dysfunction plays pathological roles. This article is part of a Special Issue entitled: Pyridoxal Phospate Enzymology...
  4. ncbi request reprint Neurobiology through the looking-glass: D-serine as a new glial-derived transmitter
    Herman Wolosker
    Department of Biochemistry, B Rappaport Faculty of Medicine, Technion Israel Institute of Technology, P O Box 9649, Bat Galim, 31096, Haifa, Israel
    Neurochem Int 41:327-32. 2002
    ....
  5. doi request reprint D-amino acids in the brain: D-serine in neurotransmission and neurodegeneration
    Herman Wolosker
    Department of Biochemistry, B Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    FEBS J 275:3514-26. 2008
    ..We now review these findings, focusing on recent questions regarding the roles of glia versus neurons in d-serine signaling...
  6. ncbi request reprint NMDA receptor regulation by D-serine: new findings and perspectives
    Herman Wolosker
    Department of Biochemistry, B Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa, 31096, Israel
    Mol Neurobiol 36:152-64. 2007
    ..In this review, I discuss recent advances in the field and propose a novel model of D-serine signaling that includes a bidirectional flow of D-serine between astrocytes and neurons...
  7. ncbi request reprint Modulation of D-serine levels via ubiquitin-dependent proteasomal degradation of serine racemase
    Elena Dumin
    Department of Biochemistry, The Bruce Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa 31096, Israel
    J Biol Chem 281:20291-302. 2006
    ..Modulation of serine racemase degradation, such as that promoted by Golga3, provides a new mechanism for regulating brain d-serine levels and NMDA receptor activity...
  8. doi request reprint Neuronal D-serine and glycine release via the Asc-1 transporter regulates NMDA receptor-dependent synaptic activity
    Dina Rosenberg
    Department of Biochemistry, The Rappaport Faculty of Medicine and Research Institute, Technion Israel Institute of Technology, Haifa 31096, Israel
    J Neurosci 33:3533-44. 2013
    ..Our data also highlight an important role of neuron-derived D-serine and glycine, indicating that astrocytic D-serine is not solely responsible for activating synaptic NMDARs...
  9. ncbi request reprint Neuron-derived D-serine release provides a novel means to activate N-methyl-D-aspartate receptors
    Elena Kartvelishvily
    Department of Biochemistry, Bruce Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa 31096, Israel
    J Biol Chem 281:14151-62. 2006
    ..Our results suggest that neurons are a major source of D-serine. Glutamate-induced neuronal D-serine release provides a novel mechanism for activating NMDA receptors by an autocrine or paracrine way...
  10. doi request reprint D-serine: physiology and pathology
    Inna Radzishevsky
    Department of Biochemistry, B Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    Curr Opin Clin Nutr Metab Care 16:72-5. 2013
    ..Here, we discuss the recent data on the role of different N-methyl D-aspartate receptor (NMDAR) coagonists, D-serine and glycine, in regulating NMDAR activity and neurotoxicity...
  11. doi request reprint Phosphorylation of mouse serine racemase regulates D-serine synthesis
    Veronika N Foltyn
    Department of Biochemistry, B Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    FEBS Lett 584:2937-41. 2010
    ..Experiments with a phosphorylation-deficient SR mutant indicate that Thr71 phosphorylation increases SR activity, suggesting a novel mechanism for regulating D-serine production...
  12. pmc AF-6 is a positive modulator of the PINK1/parkin pathway and is deficient in Parkinson's disease
    Joseph Haskin
    Department of Pharmacology, The Rappaport Faculty of Medicine and Research Institute, Technion Israel Institute of Technology, Bat Galim, Haifa, Israel
    Hum Mol Genet 22:2083-96. 2013
    ..The identification of AF-6 as a positive modulator of parkin translocation to the mitochondria sheds light on the mechanisms involved in PD and underscores AF-6 as a novel target for future therapeutics...
  13. pmc Neuronal release of D-serine: a physiological pathway controlling extracellular D-serine concentration
    Dina Rosenberg
    Department of Biochemistry, B Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa 31096, Israel
    FASEB J 24:2951-61. 2010
    ..Our data indicate that the neuronal pool of D-serine plays a major role in D-serine dynamics, with implications for the regulation of NMDAR transmission...
  14. ncbi request reprint A CSF and postmortem brain study of D-serine metabolic parameters in schizophrenia
    Inna Bendikov
    Department of Biochemistry, B Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa 31096, Israel
    Schizophr Res 90:41-51. 2007
    ..Our results suggest that reduced brain serine racemase and elevated D-amino acid oxidase protein levels may contribute to the lower CSF D-serine levels in schizophrenia...
  15. ncbi request reprint Serine racemase modulates intracellular D-serine levels through an alpha,beta-elimination activity
    Veronika N Foltyn
    Department of Biochemistry, Technion Israel Institute of Technology, The B Rappaport Faculty of Medicine, Haifa 31096, Israel
    J Biol Chem 280:1754-63. 2005
    ..Extracellular D-serine is more stable toward alpha,beta-elimination, likely due to physical separation from serine racemase and its elimination activity...
  16. pmc Feedback inactivation of D-serine synthesis by NMDA receptor-elicited translocation of serine racemase to the membrane
    Livia Balan
    Department of Biochemistry, Bruce Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa 31096, Israel
    Proc Natl Acad Sci U S A 106:7589-94. 2009
    ..We propose that the inhibition of D-serine synthesis caused by translocation of SR to the membrane provides a fail-safe mechanism to prevent NMDAR overactivation in vicinal cells or synapses...
  17. pmc Synphilin-1A inhibits seven in absentia homolog (SIAH) and modulates alpha-synuclein monoubiquitylation and inclusion formation
    Raymonde Szargel
    Department of Pharmacology, The B Rappaport Faculty of Medicine and Institute of Medical Research, Technion Israel Institute of Technology, Haifa 31096, Israel
    J Biol Chem 284:11706-16. 2009
    ..Our results suggest a novel function for synphilin-1A as a regulator of SIAH activity and formation of Lewy body-like inclusions...
  18. ncbi request reprint D-serine is the dominant endogenous coagonist for NMDA receptor neurotoxicity in organotypic hippocampal slices
    Maria Shleper
    Department of Biochemistry, B Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa 31096, Israel
    J Neurosci 25:9413-7. 2005
    ..The results suggest an essential role for this unusual D-amino acid, with implications for the mechanism of neuronal death in the nervous system...
  19. doi request reprint An enzymatic-HPLC assay to monitor endogenous D-serine release from neuronal cultures
    Inna Radzishevsky
    Department of Biochemistry, Technion Israel Institute of Technology, Haifa, Israel
    Methods Mol Biol 794:291-7. 2012
    ....
  20. doi request reprint The serine shuttle between glia and neurons: implications for neurotransmission and neurodegeneration
    Herman Wolosker
    Department of Biochemistry, The Rappaport Faculty of Medicine and Research Institute, Technion Israel Institute of Technology, Haifa 31096, Israel
    Biochem Soc Trans 41:1546-50. 2013
    ..We incorporate these new findings in a revised model of serine dynamics, called the glia-neuron serine shuttle, which highlights the role of glia-neuron cross-talk for optimal NMDAR activity and brain development. ..
  21. ncbi request reprint Glial transport of the neuromodulator D-serine
    Cátia S Ribeiro
    Department of Biochemistry, Federal University of Rio de Janeiro, Rio de Janeiro 21491 590, Brazil
    Brain Res 929:202-9. 2002
    ..The features of D-serine transport we describe reveal possible new mechanisms controlling the synaptic concentration of D-serine...
  22. pmc Cofactors of serine racemase that physiologically stimulate the synthesis of the N-methyl-D-aspartate (NMDA) receptor coagonist D-serine
    Joari De Miranda
    Department of Biochemistry, Federal University of Rio de Janeiro, Rio de Janeiro RJ 21941 590, Brazil
    Proc Natl Acad Sci U S A 99:14542-7. 2002
    ..Our data link the production of d-serine to the energy metabolism, with implications for the metabolic and transmitter crosstalk between glia and neurons...
  23. ncbi request reprint Endogenous D-serine contributes to NMDA-receptor-mediated light-evoked responses in the vertebrate retina
    Eric C Gustafson
    Department of Neuroscience, 6 145 Jackson Hall, University of Minnesota, Minneapolis, MN 55455, USA
    J Neurophysiol 98:122-30. 2007
    ..Furthermore under our experimental conditions, these coagonist sites are not saturated so that modulation of NMDAR sensitivity can be achieved with further modulaton of d-serine...
  24. ncbi request reprint Slow-binding human serine racemase inhibitors from high-throughput screening of combinatorial libraries
    Seth M Dixon
    Department of Chemistry, University of California, One Shields Avenue, Davis, CA 95616, USA
    J Med Chem 49:2388-97. 2006
    ..They provide a pharmacophore for the future isolation of more potent ligands that may prove useful in probing and understanding the biological role of hSR...
  25. doi request reprint Increased brain D-amino acid oxidase (DAAO) activity in schizophrenia
    Caroline Madeira
    Dept de Anatomia, Instituto de Ciencias Biomedicas, Universidade Federal do Rio de Janeiro, Brazil
    Schizophr Res 101:76-83. 2008
    ..These findings provide indications that D-serine availability in the nervous system may be altered in schizophrenia because of increased D-amino acid degradation by DAAO...