Orly Weinreb

Summary

Affiliation: Technion-Israel Institute of Technology
Country: Israel

Publications

  1. ncbi request reprint cDNA gene expression profile homology of antioxidants and their antiapoptotic and proapoptotic activities in human neuroblastoma cells
    Orly Weinreb
    Department of Pharmacology, Technion Faculty of Medicine, P O B 9697, 31096 Haifa, Israel
    FASEB J 17:935-7. 2003
  2. ncbi request reprint Involvement of multiple survival signal transduction pathways in the neuroprotective, neurorescue and APP processing activity of rasagiline and its propargyl moiety
    O Weinreb
    Eve Topf and USA National Parkinson Foundation Centers of Excellence for Neurodegenerative Diseases Research, Department of Pharmacology, Rappaport Family Research Institute, Technion Faculty of Medicine, Haifa, Israel
    J Neural Transm Suppl . 2006
  3. ncbi request reprint The novel multi-target iron chelator, M30 modulates HIF-1α-related glycolytic genes and insulin signaling pathway in the frontal cortex of APP/PS1 Alzheimer's disease mice
    Danit Mechlovich
    Eve Topf Center, Technion Faculty of Medicine P O BOX 9697, 31096 Haifa, Israel
    Curr Alzheimer Res 11:119-27. 2014
  4. pmc Recent advances in amyotrophic lateral sclerosis research: perspectives for personalized clinical application
    Chen Benkler
    Felsenstein Medical Research Center, Tel Aviv University, Tel Aviv, Israel
    EPMA J 1:343-61. 2010
  5. doi request reprint Targeting dysregulation of brain iron homeostasis in Parkinson's disease by iron chelators
    Orly Weinreb
    Eve Topf Centers of Excellence for Neurodegenerative Diseases Research, Department of Pharmacology, Faculty of Medicine, Technion Israel Institute of Technology, Haifa 31096, Israel
    Free Radic Biol Med 62:52-64. 2013
  6. pmc Neuroprotective molecular mechanisms of (-)-epigallocatechin-3-gallate: a reflective outcome of its antioxidant, iron chelating and neuritogenic properties
    Orly Weinreb
    Eve Topf and USA National Parkinson Foundation Centers of Excellence for Neurodegenerative Diseases Research, Technion Faculty of Medicine, Haifa, Israel
    Genes Nutr 4:283-96. 2009
  7. ncbi request reprint Ladostigil: a novel multimodal neuroprotective drug with cholinesterase and brain-selective monoamine oxidase inhibitory activities for Alzheimer's disease treatment
    Orly Weinreb
    Department of Pharmacology, Rappaport Family Research Institute, Haifa, Israel
    Curr Drug Targets 13:483-94. 2012
  8. doi request reprint Genomic and proteomic study to survey the mechanism of action of the anti-Parkinson's disease drug, rasagiline compared with selegiline, in the rat midbrain
    Orly Weinreb
    Department of Pharmacology, Technion Faculty of Medicine, Rappaport Family Research Institute, Eve Topf Centers of Excellence for Neurodegenerative Diseases Research, Haifa, Israel
    J Neural Transm (Vienna) 116:1457-72. 2009
  9. doi request reprint Neuroprotective multifunctional iron chelators: from redox-sensitive process to novel therapeutic opportunities
    Orly Weinreb
    Eve Topf Centers of Excellence for Neurodegenerative Diseases Research and Department of Pharmacology, Rappaport Family Research Institute, Technion Faculty of Medicine, Haifa, Israel
    Antioxid Redox Signal 13:919-49. 2010
  10. ncbi request reprint The neuroprotective mechanism of action of the multimodal drug ladostigil
    Orly Weinreb
    Eve Topf and USA National Parkinson Foundation Centers of Excellence for Neurodegenerative Diseases Research and Department of Pharmacology, Rappaport Family Research Institute, Technion Faculty of Medicine, Haifa, 31096, Israel
    Front Biosci 13:5131-7. 2008

Collaborators

Detail Information

Publications70

  1. ncbi request reprint cDNA gene expression profile homology of antioxidants and their antiapoptotic and proapoptotic activities in human neuroblastoma cells
    Orly Weinreb
    Department of Pharmacology, Technion Faculty of Medicine, P O B 9697, 31096 Haifa, Israel
    FASEB J 17:935-7. 2003
    ..Our results provide for the first time new insights into the molecular events involved in the dose-dependent neuroprotective and neurotoxic activities of catechols and indole amine compounds...
  2. ncbi request reprint Involvement of multiple survival signal transduction pathways in the neuroprotective, neurorescue and APP processing activity of rasagiline and its propargyl moiety
    O Weinreb
    Eve Topf and USA National Parkinson Foundation Centers of Excellence for Neurodegenerative Diseases Research, Department of Pharmacology, Rappaport Family Research Institute, Technion Faculty of Medicine, Haifa, Israel
    J Neural Transm Suppl . 2006
    ....
  3. ncbi request reprint The novel multi-target iron chelator, M30 modulates HIF-1α-related glycolytic genes and insulin signaling pathway in the frontal cortex of APP/PS1 Alzheimer's disease mice
    Danit Mechlovich
    Eve Topf Center, Technion Faculty of Medicine P O BOX 9697, 31096 Haifa, Israel
    Curr Alzheimer Res 11:119-27. 2014
    ....
  4. pmc Recent advances in amyotrophic lateral sclerosis research: perspectives for personalized clinical application
    Chen Benkler
    Felsenstein Medical Research Center, Tel Aviv University, Tel Aviv, Israel
    EPMA J 1:343-61. 2010
    ..This review will discuss novel pharmacological approaches concerning adjusted therapy for ALS patients: iron-binding brain permeable multimodal compounds, genetic manipulation and cell-based treatment...
  5. doi request reprint Targeting dysregulation of brain iron homeostasis in Parkinson's disease by iron chelators
    Orly Weinreb
    Eve Topf Centers of Excellence for Neurodegenerative Diseases Research, Department of Pharmacology, Faculty of Medicine, Technion Israel Institute of Technology, Haifa 31096, Israel
    Free Radic Biol Med 62:52-64. 2013
    ....
  6. pmc Neuroprotective molecular mechanisms of (-)-epigallocatechin-3-gallate: a reflective outcome of its antioxidant, iron chelating and neuritogenic properties
    Orly Weinreb
    Eve Topf and USA National Parkinson Foundation Centers of Excellence for Neurodegenerative Diseases Research, Technion Faculty of Medicine, Haifa, Israel
    Genes Nutr 4:283-96. 2009
    ..In the current review, we discuss the studies concerning the mechanisms of action implicated in EGCG-induced neuroprotection and discuss the vision to translate these findings into a lifestyle arena...
  7. ncbi request reprint Ladostigil: a novel multimodal neuroprotective drug with cholinesterase and brain-selective monoamine oxidase inhibitory activities for Alzheimer's disease treatment
    Orly Weinreb
    Department of Pharmacology, Rappaport Family Research Institute, Haifa, Israel
    Curr Drug Targets 13:483-94. 2012
    ....
  8. doi request reprint Genomic and proteomic study to survey the mechanism of action of the anti-Parkinson's disease drug, rasagiline compared with selegiline, in the rat midbrain
    Orly Weinreb
    Department of Pharmacology, Technion Faculty of Medicine, Rappaport Family Research Institute, Eve Topf Centers of Excellence for Neurodegenerative Diseases Research, Haifa, Israel
    J Neural Transm (Vienna) 116:1457-72. 2009
    ....
  9. doi request reprint Neuroprotective multifunctional iron chelators: from redox-sensitive process to novel therapeutic opportunities
    Orly Weinreb
    Eve Topf Centers of Excellence for Neurodegenerative Diseases Research and Department of Pharmacology, Rappaport Family Research Institute, Technion Faculty of Medicine, Haifa, Israel
    Antioxid Redox Signal 13:919-49. 2010
    ..This review discusses two interrelated approaches concerning therapy targets in neurodegeneration, sharing in common the implementation of iron chelation activity: antioxidation and HIF-1-pathway activation...
  10. ncbi request reprint The neuroprotective mechanism of action of the multimodal drug ladostigil
    Orly Weinreb
    Eve Topf and USA National Parkinson Foundation Centers of Excellence for Neurodegenerative Diseases Research and Department of Pharmacology, Rappaport Family Research Institute, Technion Faculty of Medicine, Haifa, 31096, Israel
    Front Biosci 13:5131-7. 2008
    ..Altogether, these scientific findings make ladostigil a potentially valuable drug for the treatment of AD...
  11. doi request reprint Does 1-(R)-aminoindan possess neuroprotective properties against experimental Parkinson's disease?
    Orly Weinreb
    Eve Topf Center of Excellence for Neurodegenerative Diseases Research and Department of Pharmacology, Technion Faculty of Medicine, Rappaport Family Research Institute, Haifa, Israel
    Antioxid Redox Signal 14:767-75. 2011
    ..These observations indicate that 1-(R)-aminoindan may contribute to the overall neuroprotective activity of its parental compound, rasagiline...
  12. doi request reprint Iron-chelating backbone coupled with monoamine oxidase inhibitory moiety as novel pluripotential therapeutic agents for Alzheimer's disease: a tribute to Moussa Youdim
    Orly Weinreb
    Eve Topf Centers of Excellence for Neurodegenerative Diseases Research and Department of Pharmacology, Rappaport Family Research Institute, Technion Faculty of Medicine, P O B 9697, 31096, Haifa, Israel
    J Neural Transm (Vienna) 118:479-92. 2011
    ....
  13. doi request reprint The application of proteomics for studying the neurorescue activity of the polyphenol (-)-epigallocatechin-3-gallate
    Orly Weinreb
    Eve Topf and USA National Parkinson Foundation Centers of Excellence for Neurodegenerative Diseases Research and Department of Pharmacology, Rappaport Family Research Institute, Technion Faculty of Medicine, Haifa 31096, Israel
    Arch Biochem Biophys 476:152-60. 2008
    ....
  14. pmc Multifunctional neuroprotective derivatives of rasagiline as anti-Alzheimer's disease drugs
    Orly Weinreb
    Eve Topf and USA National Parkinson Foundation Centers of Excellence for Neurodegenerative Diseases Research and Department of Pharmacology, Rappaport Family Research Institute, Technion Faculty of Medicine, Haifa, 31096, Israel
    Neurotherapeutics 6:163-74. 2009
    ..Altogether, these scientific findings make these multifunctional compounds potentially valuable drugs for the treatment of Alzheimer's disease...
  15. doi request reprint The novel cholinesterase-monoamine oxidase inhibitor and antioxidant, ladostigil, confers neuroprotection in neuroblastoma cells and aged rats
    Orit Bar-Am
    Eve Topf and USA National Parkinson Foundation Centers of Excellence for Neurodegenerative Diseases Research and Department of Pharmacology, Rappaport Family Research Institute, Faculty of Medicine, Technion, Haifa, 31096, Israel
    J Mol Neurosci 37:135-45. 2009
    ....
  16. ncbi request reprint Regulation of Bcl-2 family proteins, neurotrophic factors, and APP processing in the neurorescue activity of propargylamine
    Orit Bar-Am
    Eve Topf and USA National Parkinson Foundation Centers of Excellence for Neurodegenerative Diseases Research, and Department of Pharmacology, Rappaport Family Research Institute, Technion Faculty of Medicine, Haifa, Israel
    FASEB J 19:1899-901. 2005
    ..These results indicate that both rasagiline and propargylamine possess neurorescue activity, associated with regulation of Bcl-2 family proteins, neurotrophic factors, and APP metabolism...
  17. ncbi request reprint A novel approach of proteomics and transcriptomics to study the mechanism of action of the antioxidant-iron chelator green tea polyphenol (-)-epigallocatechin-3-gallate
    Orly Weinreb
    Eve Topf and USA National Parkinson Foundation Centers of Excellence for Neurodegenerative Diseases Research and Department of Pharmacology, Rappaport Family Research Institute, Technion Faculty of Medicine, Haifa 31096, Israel
    Free Radic Biol Med 43:546-56. 2007
    ..Thus, the present study sheds some light on the antioxidative-iron chelating activities of EGCG underlying its neuroprotective/neurorescue mechanism of action, further suggesting a potential neurodegenerative-modifying effect for EGCG...
  18. ncbi request reprint Neurological mechanisms of green tea polyphenols in Alzheimer's and Parkinson's diseases
    Orly Weinreb
    Eve Topf and USA National Parkinson Foundation Centers of Excellence for Neurodegenerative Diseases Research and Department of Pharmacology, Rappaport Family Research Institute, Technion Faculty of Medicine, 31096 Haifa, Israel
    J Nutr Biochem 15:506-16. 2004
    ..In particular, literature on the putative novel neuroprotective mechanism of the major green tea polyphenol, (-)-epigallocatechin-3-gallate, are examined and discussed in this review...
  19. ncbi request reprint Green tea catechins as brain-permeable, natural iron chelators-antioxidants for the treatment of neurodegenerative disorders
    Silvia Mandel
    Eve Topf, Haifa, Israel
    Mol Nutr Food Res 50:229-34. 2006
    ....
  20. ncbi request reprint A multifunctional, neuroprotective drug, ladostigil (TV3326), regulates holo-APP translation and processing
    Merav Yogev-Falach
    Eve Topf Center of Excellence for Neurodegenerative Diseases Research and Dept of Pharmacology, Rappaport Family Research Institute, Technion Faculty of Medicine, 31096 Haifa, Israel
    FASEB J 20:2177-9. 2006
    ..Similar to ladostigil, its S-isomer, TV3279, which is a ChE inhibitor but lacks MAO inhibitory activity, exerted neuroprotective properties and regulated APP processing, indicating that these effects are independent of MAO inhibition...
  21. ncbi request reprint The application of proteomics and genomics to the study of age-related neurodegeneration and neuroprotection
    Orly Weinreb
    Eve Topf Center of Excellence for Neurodegenerative Diseases Research and Department of Pharmacology, Rappaport Family Research Institute, Faculty of Medicine, Technion, Haifa, Israel
    Antioxid Redox Signal 9:169-79. 2007
    ..These results support the hypothesis that OS and mitochondrial dysfunction may play a pivotal role in aging and age-associated neurodegenerative diseases, and can serve as potential clinical targets for future therapy...
  22. doi request reprint Additive Neuroprotective Effects of the Multifunctional Iron Chelator M30 with Enriched Diet in a Mouse Model of Amyotrophic Lateral Sclerosis
    Sagit Golko-Perez
    Eve Topf Center, Faculty of Medicine, Technion Israel Institute of Technology, P O B 9697, 31096, Haifa, Israel
    Neurotox Res 29:208-17. 2016
    ..These results suggest that a combination of drug/agents with different, but complementary mechanisms may be beneficial in the treatment of ALS. ..
  23. ncbi request reprint Gene and protein expression profiles of anti- and pro-apoptotic actions of dopamine, R-apomorphine, green tea polyphenol (-)-epigallocatechine-3-gallate, and melatonin
    Orly Weinreb
    Eve Topf, Haifa, Israel
    Ann N Y Acad Sci 993:351-61; discussion 387-93. 2003
    ..We have shown that DA, R-APO, EGCG, and melatonin exhibit similar gene expression and protein profiles...
  24. doi request reprint Simultaneous manipulation of multiple brain targets by green tea catechins: a potential neuroprotective strategy for Alzheimer and Parkinson diseases
    Silvia A Mandel
    Eve Topf Center for Neurodegenerative Diseases Research and Department of Pharmacology, Faculty of Medicine, Technion, Haifa, Israel
    CNS Neurosci Ther 14:352-65. 2008
    ..In the current article, we review the literature on the impact of the multimodal activities of green tea polyphenols and their neuroprotective effect on AD and PD...
  25. doi request reprint Effects of novel neuroprotective and neurorestorative multifunctional drugs on iron chelation and glucose metabolism
    Yulia Pollak
    Pediatric Research and Electron Microscopy Unit, Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    J Neural Transm (Vienna) 120:37-48. 2013
    ..Such effects can have therapeutic significance in conditions with abnormal local or systemic iron metabolism, including neurological diseases...
  26. doi request reprint Neuroprotection by the multitarget iron chelator M30 on age-related alterations in mice
    Lana Kupershmidt
    Eve Topf Centers of Excellence for Neurodegenerative Diseases Research and Department of Pharmacology, Rappaport Family Research Institute Technion Faculty of Medicine, Haifa 31096, Israel
    Mech Ageing Dev 133:267-74. 2012
    ....
  27. doi request reprint Rasagiline: a novel anti-Parkinsonian monoamine oxidase-B inhibitor with neuroprotective activity
    Orly Weinreb
    Eve Topf Centre of Excellence for Neurodegenerative Diseases, Technion Rappaport Faculty of Medicine, Efron St PO Box 9697, Haifa 31096, Israel
    Prog Neurobiol 92:330-44. 2010
    ..This paper will review the earlier and present studies in the development of rasagiline for treatment of PD and discuss its pharmacology and applicable mechanism of action...
  28. ncbi request reprint Novel neuroprotective mechanism of action of rasagiline is associated with its propargyl moiety: interaction of Bcl-2 family members with PKC pathway
    Orly Weinreb
    Eve Topf and USA National Parkinson Foundation Centers of Excellence for Neurodegenerative Diseases Research, Department of Pharmacology, Rappaport Family Research Institute, Technion Faculty of Medicine, Haifa, Israel
    Ann N Y Acad Sci 1053:348-55. 2005
    ..These results have led us to develop several multifunctional neuroprotective drugs containing the propargyl moiety and iron-chelating property for the treatment and/or prevention of neurodegenerative diseases...
  29. doi request reprint The neuroprotective effect of ladostigil against hydrogen peroxide-mediated cytotoxicity
    Orly Weinreb
    Eve Topf and USA National Parkinson Foundation Centers of Excellence for Neurodegenerative Diseases Research and Department of Pharmacology, Rappaport Family Research Institute, Technion Faculty of Medicine, Haifa, Israel
    Chem Biol Interact 175:318-26. 2008
    ....
  30. ncbi request reprint Cell signaling pathways and iron chelation in the neurorestorative activity of green tea polyphenols: special reference to epigallocatechin gallate (EGCG)
    Silvia A Mandel
    Eve Topf Center for Neurodegenerative Diseases Research and Department of Pharmacology, Faculty of Medicine, Technion, Haifa, Israel
    J Alzheimers Dis 15:211-22. 2008
    ..This review provides a detailed overview on the multimodal activities of green tea polyphenols with emphasis on their iron chelating, neurorescue/neuroregenerative and mitochondrial stabilization action...
  31. doi request reprint DJ-1 deficiency triggers microglia sensitivity to dopamine toward a pro-inflammatory phenotype that is attenuated by rasagiline
    Dorit Trudler
    Department of Neurobiology, George S Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel Sagol School of Neuroscience, George S Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel
    J Neurochem 129:434-47. 2014
    ..Further studies of DJ-1-mediated cellular pathways in microglia may contribute useful insights into the development of PD providing future avenues for therapeutic intervention..
  32. ncbi request reprint Rasagiline: neurodegeneration, neuroprotection, and mitochondrial permeability transition
    Moussa B H Youdim
    Eve Topf and USA National Parkinson Foundation Centers of Excellence for Neurodegenerative Diseases Research and Department of Pharmacology, Technion Faculty of Medicine, 31096 Haifa, Israel
    J Neurosci Res 79:172-9. 2005
    ....
  33. ncbi request reprint Neurorescue activity, APP regulation and amyloid-beta peptide reduction by novel multi-functional brain permeable iron- chelating- antioxidants, M-30 and green tea polyphenol, EGCG
    Yael Avramovich-Tirosh
    Eve Topf and USA NPF Centers of Excellence, Technion Rappaport Family Faculty of Medicine and Department of Pharmacology, Haifa, Israel
    Curr Alzheimer Res 4:403-11. 2007
    ....
  34. pmc Physiological and pathological aspects of Abeta in iron homeostasis via 5'UTR in the APP mRNA and the therapeutic use of iron-chelators
    Yael Avramovich-Tirosh
    Department of Pharmacology, Eve Topf and USA NPF Centers of Excellence, Technion Faculty of Medicine, Haifa, Israel
    BMC Neurosci 9:S2. 2008
    ....
  35. doi request reprint The involvement of GABA(A) receptor in the molecular mechanisms of combined selective serotonin reuptake inhibitor-antipsychotic treatment
    Lena Danovich
    Molecular Neuropsychiatry Unit, Shaar Menashe Brain Behavior Laboratory, Shaar Menashe MHC and Technion Faculty of Medicine, Haifa, Israel
    Int J Neuropsychopharmacol 14:143-55. 2011
    ..Inhibition of ERK2 did not alter the effect of drugs on GABA(A) receptor phosphorylation levels. Our findings provide evidence that the combined treatment regulates GABA(A) receptor function and does so via a PKC-dependent pathway...
  36. ncbi request reprint Neuroprotection via pro-survival protein kinase C isoforms associated with Bcl-2 family members
    Orly Weinreb
    Eve Topf and Rappaport Family Research Institute, Technion Faculty of Medicine, Haifa, Israel
    FASEB J 18:1471-3. 2004
    ..Furthermore, these studies have established that PKC- and Bcl-2-dependent neuroprotective activity of rasagiline is dependent on its propargyl moiety, because propargylamine had similar effects with the same potency...
  37. doi request reprint Neuroprotective and neuritogenic activities of novel multimodal iron-chelating drugs in motor-neuron-like NSC-34 cells and transgenic mouse model of amyotrophic lateral sclerosis
    Lana Kupershmidt
    Eve Topf and USA National Parkinson Foundation Centers of Excellence for Neurodegenerative Diseases Research, Haifa, Israel
    FASEB J 23:3766-79. 2009
    ..These properties of the novel multimodal iron-chelating drugs possessing neuroprotective/neuritogenic activities may offer future therapeutic possibilities for motor neurodegenerative diseases...
  38. ncbi request reprint Molecular mechanisms of the neuroprotective/neurorescue action of multi-target green tea polyphenols
    Silvia A Mandel
    Eve Topf Center for Neurodegenerative Diseases Research and Department of Molecular Pharmacology, Faculty of Medicine, Technion, Haifa, Israel
    Front Biosci (Schol Ed) 4:581-98. 2012
    ....
  39. doi request reprint Multi-target, neuroprotective and neurorestorative M30 improves cognitive impairment and reduces Alzheimer's-like neuropathology and age-related alterations in mice
    Lana Kupershmidt
    Eve Topf and USA National Parkinson Foundation Centers of Excellence for Neurodegenerative Diseases Research and Department of Pharmacology, Technion Faculty of Medicine, P O Box 9697, Haifa 31096, Israel
    Mol Neurobiol 46:217-20. 2012
    ..The diverse pharmacological properties and several pathological targets of M30 make this drug potential valuable for therapeutic strategy of Alzheimer's-like neuropathology and aging...
  40. ncbi request reprint Multifunctional activities of green tea catechins in neuroprotection. Modulation of cell survival genes, iron-dependent oxidative stress and PKC signaling pathway
    Silvia A Mandel
    Eve Topf and USA National Parkinson Foundation Centers of Excellence for Neurodegenerative Diseases Research, Technion Faculty of Medicine, Haifa, Israel
    Neurosignals 14:46-60. 2005
    ..In particular, their transitional metal (iron and copper) chelating property and inhibition of oxidative stress...
  41. doi request reprint SSRI augmentation of antipsychotic alters expression of GABA(A) receptor and related genes in PMC of schizophrenia patients
    Henry Silver
    Molecular Neuropsychiatry Unit, Sha ar Menashe Brain Behavior Laboratory, Sha ar Menashe Mental Health Center, and Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    Int J Neuropsychopharmacol 14:573-84. 2011
    ..These changes may be part of the mechanism of clinically effective drug action and may prove to be biomarkers of pharmacological response...
  42. doi request reprint Understanding the broad-spectrum neuroprotective action profile of green tea polyphenols in aging and neurodegenerative diseases
    Silvia A Mandel
    Eve Topf Center for Neurodegenerative Diseases Research and Department of Molecular Pharmacology, Faculty of Medicine, Technion, Haifa, Israel
    J Alzheimers Dis 25:187-208. 2011
    ....
  43. doi request reprint The novel multi-target iron chelating-radical scavenging compound M30 possesses beneficial effects on major hallmarks of Alzheimer's disease
    Lana Kupershmidt
    Eve Topf and USA National Parkinson Foundation Centers of Excellence for Neurodegenerative Diseases Research, Haifa, Israel
    Antioxid Redox Signal 17:860-77. 2012
    ....
  44. doi request reprint Neuroprotective profile of the multitarget drug rasagiline in Parkinson's disease
    Orly Weinreb
    Eve Topf Centre of Excellence for Neurodegenerative Diseases and Department of Molecular Pharmacology, Technion Rappaport Faculty of Medicine, Efron Street, P O Box 9697, Haifa, Israel
    Int Rev Neurobiol 100:127-49. 2011
    ..This review reflects on earlier and present evidence supporting a role for rasagiline as a neuroprotective molecule in the treatment of PD...
  45. doi request reprint A novel anti-Alzheimer's disease drug, ladostigil neuroprotective, multimodal brain-selective monoamine oxidase and cholinesterase inhibitor
    Orly Weinreb
    Eve Topf Centre of Excellence for Neurodegenerative Diseases and Department of Molecular Pharmacology, Technion Rappaport Faculty of Medicine, Efron Street, P O Box 9697, Haifa, Israel
    Int Rev Neurobiol 100:191-215. 2011
    ..This chapter will discuss the preclinical scientific evidence for the therapeutic potential use of ladostigil in the clinic and molecular signaling pathways that are considered to be involved in the molecular activities of the drug...
  46. doi request reprint Propargylamine containing compounds as modulators of proteolytic cleavage of amyloid-beta protein precursor: involvement of MAPK and PKC activation
    Orit Bar-Am
    Eve Topf and USA National Parkinson Foundation Centers of Excellence for Neurodegenerative Diseases Research and Department of Pharmacology, Rappaport Family Research Institute, Technion Faculty of Medicine, Haifa, Israel
    J Alzheimers Dis 21:361-71. 2010
    ..This review will summarize and discuss current research, focused on the effect of propargylamine-related derivatives on the proteolytic processing of AbetaPP and signal transduction mechanisms...
  47. ncbi request reprint Cell signaling pathways in the neuroprotective actions of the green tea polyphenol (-)-epigallocatechin-3-gallate: implications for neurodegenerative diseases
    Silvia Mandel
    Eve Topf and USA National Parkinson Foundation Centers of Excellence for Neurodegenerative Diseases Research and Department of Pharmacology, Technion Faculty of Medicine, Haifa, Israel
    J Neurochem 88:1555-69. 2004
    ....
  48. ncbi request reprint Gene expression changes in peripheral mononuclear cells from schizophrenic patients treated with a combination of antipsychotic with fluvoxamine
    Yael Chertkow
    Molecular Neuropsychiatry Unit, Shaar Menashe Brain Behavior Laboratory, Shaar Menashe MHC, and Technion Faculty of Medicine, Haifa, Israel
    Prog Neuropsychopharmacol Biol Psychiatry 31:1356-62. 2007
    ..Our findings suggest that gene expression changes in PMC may be useful in investigating the mechanism of drug action in schizophrenia...
  49. doi request reprint Neuroprotective and neurorestorative potential of propargylamine derivatives in ageing: focus on mitochondrial targets
    Orit Bar-Am
    Eve Topf Centers of Excellence for Neurodegenerative Diseases Research, Faculty of Medicine, Technion Israel Institute of Technology, P O B 9697, 31096, Haifa, Israel
    J Neural Transm (Vienna) 123:125-35. 2016
    ..g., the monoamine oxidase-B inhibitors, selegiline and rasagiline and the multifunctional drugs, ladostigil, M30 and VAR10303) in ageing with a special focus on mitochondrial molecular protective mechanisms. ..
  50. ncbi request reprint Induction of neurotrophic factors GDNF and BDNF associated with the mechanism of neurorescue action of rasagiline and ladostigil: new insights and implications for therapy
    Orly Weinreb
    Department of Pharmacology, Rappaport Family Research Institute, Technion Faculty of Medicine, P O Box 9697, 31096 Haifa, Israel
    Ann N Y Acad Sci 1122:155-68. 2007
    ..These studies indicate that the induction of NTFs by rasagiline and ladostigil might suppress apoptosis and induce neurorescue in neurodegenerative disorders and may support the drugs' possible disease-modifying mechanism of action...
  51. doi request reprint Chronic treatment with serotonin reuptake inhibitor antidepressant (SSRI) combined with an antipsychotic regulates GABA-A receptor in rat prefrontal cortex
    Lena Danovich
    Molecular Neuropsychiatry Unit, Shaar Menashe Brain Behavior Laboratory, Shaar Menashe MHC and Technion Faculty of Medicine, Mobile Post, 38814, Haifa, Israel
    Psychopharmacology (Berl) 220:763-70. 2012
    ....
  52. ncbi request reprint Using cDNA microarray to assess Parkinson's disease models and the effects of neuroprotective drugs
    Silvia Mandel
    Eve Topf and US National Parkinson Foundation Centers of Excellence for Neurodegenerative Diseases Research and Department of Pharmacology, Technion Rappaport Faculty of Medicine, PO Box 9697, Haifa 31096, Israel
    Trends Pharmacol Sci 24:184-91. 2003
    ....
  53. doi request reprint Improvement in verbal memory following SSRI augmentation of antipsychotic treatment is associated with changes in the expression of mRNA encoding for the GABA-A receptor and BDNF in PMC of schizophrenic patients
    Henry Silver
    aMolecular Neuropsychiatry Unit bClinical Research Unit, Sha ar Menashe Brain Behavior Laboratory, Sha ar Menashe Mental Health Center cEve Topf and National Parkinson Foundation Centers of Excellence for Neurodegenerative Diseases Research, Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel dDepartment of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Int Clin Psychopharmacol 30:158-66. 2015
    ..Addition of fluvoxamine to antipsychotics improves verbal memory. It is postulated that the mechanism involves enhanced GABA-A receptor/BDNF-dependent synaptic plasticity in the hippocampus...
  54. ncbi request reprint The role of GABA-A receptor in the synergism between SSRI and antipsychotic in schizophrenia; implications for antipsychotic modes of actions
    Henry Silver
    Molecular Neuropsychiatry Unit, Brain Behavior Laboratory, Technion Faculty of Medicine, Haifa, Israel
    Curr Med Chem 20:363-70. 2013
    ..In this paper, we review these studies and propose that modulation of the gamma-aminobutyric acid (GABA)-A receptor and its regulating system is the mechanism by which SSRI antipsychotic synergism exerts its clinical efficacy...
  55. doi request reprint Novel therapeutic approach for neurodegenerative pathologies: multitarget iron-chelating drugs regulating hypoxia-inducible factor 1 signal transduction pathway
    Orly Weinreb
    Eve Topf Centers of Excellence for Neurodegenerative Diseases Research and Department of Molecular Pharmacology, Rappaport Family Research Institute, Technion Faculty of Medicine, Haifa, Israel
    Neurodegener Dis 10:112-5. 2012
    ..This mini-review will discuss the multifunctional mechanisms of action of the drugs, M30 and HLA20 in preclinical models of neurodegeneration with a specific emphasis on their ability to activate the HIF-1 signal transduction pathway...
  56. doi request reprint The neuroprotective mechanism of 1-(R)-aminoindan, the major metabolite of the anti-parkinsonian drug rasagiline
    Orit Bar-Am
    Eve Topf and USA National Parkinson Foundation Centers of Excellence for Neurodegenerative Diseases Research and Department of Pharmacology, Rappaport Family Research Institute, Technion Faculty of Medicine, Haifa, Israel
    J Neurochem 112:1131-7. 2010
    ..This review article briefly highlights the molecular mechanisms underlying the neuroprotective properties of the active metabolite of rasagiline, 1-(R)-aminoindan, supporting the valuable potential of rasagiline for disease modification...
  57. doi request reprint Molecular mechanisms underlying synergistic effects of SSRI-antipsychotic augmentation in treatment of negative symptoms in schizophrenia
    Yael Chertkow
    Eve Topf Center of Excellence for Neurodegenerative Diseases Research, Department of Pharmacology, Technion Faculty of Medicine, Haifa, Israel
    J Neural Transm (Vienna) 116:1529-41. 2009
    ..While as yet limited in scope, the evidence suggests definable molecular targets which may be implicated in drug development based on SSRI-antipsychotic synergistic actions...
  58. doi request reprint Promises of novel multi-target neuroprotective and neurorestorative drugs for Parkinson's disease
    Moussa B H Youdim
    Technion Rappaport Faculty of Medicine, Eve Topf and NPF Centers of Excellence for Neurodegenerative Diseases, Haifa, Israel Abital Pharma Pipeline Ltd, Tel Aviv, Israel Electronic address
    Parkinsonism Relat Disord 20:S132-6. 2014
    ..These unique multiple actions of M30 make it potentially useful as a disease modifying drug for the treatment of PD. ..
  59. ncbi request reprint Proceedings from the "Third International Conference on Mechanism of Action of Nutraceuticals"
    Silvia Mandel
    Eve Topf, USA National Parkinson Foundation Centers of Excellence for Neurodegenerative Diseases Research, Rappaport Family Research Institute, Technion Faculty of Medicine, Haifa 31096, Israel
    J Nutr Biochem 16:513-20. 2005
    ..This review summarizes the latest research finding in functional foods and micronutrients in the promotion of health and reduction of risk for major chronic diseases as presented in this symposium...
  60. doi request reprint Design, synthesis and evaluation of novel dual monoamine-cholinesterase inhibitors as potential treatment for Alzheimer's disease
    Wei Liu
    Eve Topf Centers of Excellence for Neurodegenerative Diseases Research, Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    Neuropharmacology 109:376-85. 2016
    ....
  61. doi request reprint A Novel Iron Chelator-Radical Scavenger Ameliorates Motor Dysfunction and Improves Life Span and Mitochondrial Biogenesis in SOD1G93A ALS Mice
    Sagit Golko-Perez
    Eve Topf Center, Faculty of Medicine, Technion Israel Institute of Technology, P O B 9697, 31096, Haifa, Israel
    Neurotox Res 31:230-244. 2017
    ..These results provide evidence of therapeutic potential of VAR-ced in SOD1G93A mice with underlying molecular mechanisms, further supporting the importance role of multitarget iron chelators in ALS treatment...
  62. doi request reprint Beneficial behavioral, neurochemical and molecular effects of 1-(R)-aminoindan in aged mice
    Felix Badinter
    Eve Topf Centers of Excellence for Neurodegenerative Diseases Research, Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    Neuropharmacology 99:264-72. 2015
    ..Altogether, the present findings indicate that AI can induce neuroprotective effects on age-related alterations in neurobehavioral functions and exerts neurotrophic up-regulatory and anti-apoptotic properties in aged animals. ..
  63. pmc Molecular targets of the multifunctional iron-chelating drug, M30, in the brains of mouse models of type 2 diabetes mellitus
    Danit Mechlovich
    Eve Topf Center for Neurodegenerative Diseases Research, Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    Br J Pharmacol 171:5636-49. 2014
    ..Here, we have characterized the molecular targets of M30 in the brains of animal models of type 2 diabetes mellitus (T2DM)...
  64. ncbi request reprint Implications of co-morbidity for etiology and treatment of neurodegenerative diseases with multifunctional neuroprotective-neurorescue drugs; ladostigil
    Moussa B H Youdim
    Technion Rappaport Family Faculty of Medicine, Eve Topf and NPF Centers for Neurodegenerative Diseases Department of Pharmacology Haifa, Israel
    Neurotox Res 10:181-92. 2006
    ..These findings indicate that the dual actions of the anti-apoptotic-neuroprotective activity and the ability to modulate APP processing, could make ladostigil a potentially valuable drug for the treatment of Alzheimer's disease...
  65. pmc Multifunctional pharmacotherapy: what can we learn from study of selective serotonin reuptake inhibitor augmentation of antipsychotics in negative-symptom schizophrenia?
    Henry Silver
    Molecular Neuropsychiatry Unit, Brain Behavior Laboratory, Shaar Menashe Mental Health Center, and Technion Faculty of Medicine, Haifa 32000, Israel
    Neurotherapeutics 6:86-93. 2009
    ..Although as yet limited in scope, the findings of definable molecular targets for synergistic SSRI-antipsychotic interaction provide new directions to inform future research and provide novel bio-molecular targets for drug development...
  66. doi request reprint Effect of long-term treatment with rasagiline on cognitive deficits and related molecular cascades in aged mice
    Orly Weinreb
    Eve Topf Centers of Excellence for Neurodegenerative Diseases Research, Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    Neurobiol Aging 36:2628-36. 2015
    ....
  67. ncbi request reprint A model of MPTP-induced Parkinson's disease in the goldfish
    Orly Weinreb
    Eve Topf and USA National Parkinson Foundation Centers of Excellence for Neurodegenerative Diseases Research, Department of Pharmacology, and Rappaport Family Research Institute, Technion Faculty of Medicine, Haifa, 31096, Israel
    Nat Protoc 2:3016-21. 2007
    ....
  68. ncbi request reprint The effect of chronic co-administration of fluvoxamine and haloperidol compared to clozapine on the GABA system in the rat frontal cortex
    Yael Chertkow
    Molecular Neuropsychiatry Unit, Shaar Menashe MHC, and Technion Faculty of Medicine, Haifa, Israel
    Int J Neuropsychopharmacol 9:287-96. 2006
    ..The present findings support the existence of a unique mechanism for SSRI-antipsychotic combination, different from that of the individual drugs and suggest that it may involve modification of the gamma aminobutyric acid (GABA) system...
  69. ncbi request reprint Mechanism of neuroprotective action of the anti-Parkinson drug rasagiline and its derivatives
    Silvia Mandel
    Eve Topf and NPF Centers of Excellence for Neurodegenerative Diseases Research, Israel
    Brain Res Brain Res Rev 48:379-87. 2005
    ..The neuroprotective activity of propargylamine has led us to develop novel bifunctional neuroprotective iron-chelating MAO-inhibiting drugs possessing propargyl moiety for the treatment of other neurodegenerative diseases...
  70. ncbi request reprint Novel multifunctional anti-Alzheimer drugs with various CNS neurotransmitter targets and neuroprotective moieties
    Cornelis J Van der Schyf
    Department of Pharmaceutical Science, Northwestern Ohio Universities College of Pharmacy, Rootstown, OH 44272, USA
    Curr Alzheimer Res 4:522-36. 2007
    ..In this review we explore some examples of multifunctional drugs which may be useful in the treatment of neurodegenerative diseases, such as Alzheimer's and Parkinson's disease...