H Silver

..These changes may be part of the mechanism of clinically effective drug action and may prove to be biomarkers of pharmacological response...

..In this paper, we review these studies and propose that modulation of the gamma-aminobutyric acid (GABA)-A receptor and its regulating system is the mechanism by which SSRI antipsychotic synergism exerts its clinical efficacy...

..NAL may thus serve as a selective marker of complex, hippocampus-based, cognitive functions in studies of normal cognitive aging and of its possible relationship to early dementia...

..Impaired processing of emotions may relate to violent behavior in schizophrenia patients. We compared emotional function in schizophrenia patients with and without a history of severe violent behavior...

..The relationship was independent of the age related reduction in DHEAS levels. These preliminary results suggest that DHEAS may be associated with cognitive impairment in schizophrenia...

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..Further studies of amantadine with different doses and treatment duration, as well as more glutamate selective agents such as memantine, are indicated...

..It has been proposed that social and cognitive deficits in schizophrenia may result from impaired error monitoring...

..Impaired ability to detect and correct errors may contribute to poor cognitive and social function in schizophrenia...

..The model presented may enable differentiation between impaired and compensating components in schizophrenia patients with an abstraction deficit...

..This preliminary study suggests that appropriate application of data-mining methods may contribute to investigation of cognitive functions...

..Although as yet limited in scope, the findings of definable molecular targets for synergistic SSRI-antipsychotic interaction provide new directions to inform future research and provide novel bio-molecular targets for drug development...

..Age-related cognitive decline might involve selective deterioration of specific brain systems. We studied the relationship between age and cognition by comparing cognitive function of older and younger high functioning men...

..Processing of neutral expressions was context dependent. Emotion impairment in schizophrenia appears to be selective for the emotion domain but not specific emotions. Test context influences how neutral facial expressions are processed...

..Some executive functions may be selectively impaired in normal aging over and above the general cognitive decline...

..This may be due to increased patient awareness of emotional aspects of stimuli and/or improvement in specific emotional perceptual skills. Further studies of Emotion Training as a potential treatment modality are warranted...

..A better understanding of these mechanisms can shed light on the pathogenesis of negative symptoms and provide new targets for drug development...

..The impairments were not related to medication dose or to extrapyramidal side effects. Visuomotor impairment may be part of illness-related pathology in schizophrenia...

..In this study we investigated the relationship among VSP, VWM and SWM...

..We compared performance on tests of perception of facial emotions with that in other cognitive areas...

..This study tested the hypothesis that impaired working memory is a core deficit underlying multiple neuropsychological deficits in schizophrenia patients...

..Persons suffering from schizophrenia have impaired perception of emotional expressions, but it is not clear whether this is part of a generalized deficit in cognitive function...

..An important goal of future studies will be to define which patient groups can benefit from combined treatment...

..Combination with clozapine may require particular caution because of potential toxicity if serum clozapine levels rise steeply. SSRI augmentation may be a useful addition to the treatment of schizophrenia...

..The combination was well tolerated. Fluvoxamine augmentation of antipsychotics is safe in chronic schizophrenic patients with mixed positive and negative symptoms and may ameliorate negative symptoms in such patients...

..The findings support the view that fluvoxamine augmentation can improve primary negative symptoms in chronic schizophrenia patients...

..Many symptoms, including those generally agreed to be core features of the illness such as alogia, improved within 2-3 weeks of treatment initiation...

..Our findings support an association between negative attitudes towards medication and poor cognitive performance, particularly of working memory...

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..The possibility that these may be relevant to the mechanism underlying the clinical effectiveness of augmentation treatment warrant further study...

..Many schizophrenic patients may have a greater capacity to experience pleasure than is apparent to the people around them...

..Our findings suggest that gene expression changes in PMC may be useful in investigating the mechanism of drug action in schizophrenia...

..The present findings support the existence of a unique mechanism for SSRI-antipsychotic combination, different from that of the individual drugs and suggest that it may involve modification of the gamma aminobutyric acid (GABA) system...

..Our findings support an association between poor insight and cognitive impairment in patients with chronic schizophrenia but suggest that the relationship may not specifically involve frontal lobe dysfunction...

..These results suggest that schizophrenia may result from an immunologic disorder, which is mediated mainly (but probably not only) by lymphocyte dysfunction...

..While as yet limited in scope, the evidence suggests definable molecular targets which may be implicated in drug development based on SSRI-antipsychotic synergistic actions...

..Patient's subjective response to these events rather than their number is more predictive of QOL...

..Nicotine can improve central processing in medicated schizophrenia patients and this may constitute part of the incentive for smoking...

..They also showed an improvement in the use of leisure time and a trend towards improvement in motivation. CONCLUSION: AAT may contribute to the psychosocial rehabilitation and quality of life of chronic schizophrenia patients...

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..The current study was designed to extend this finding by examining the relationship between neuropsychological functioning and homocysteine levels in euthymic bipolar patients...