H Silver

Summary

Affiliation: Technion-Israel Institute of Technology
Country: Israel

Publications

  1. doi request reprint SSRI augmentation of antipsychotic alters expression of GABA(A) receptor and related genes in PMC of schizophrenia patients
    Henry Silver
    Molecular Neuropsychiatry Unit, Sha ar Menashe Brain Behavior Laboratory, Sha ar Menashe Mental Health Center, and Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    Int J Neuropsychopharmacol 14:573-84. 2011
  2. doi request reprint Pathways to similar executive impairment: comparison of schizophrenia patients and healthy aging individuals
    Henry Silver
    Brain Behavior Laboratory, Sha ar Menashe Mental Health Center, Mobile Post Hefer 38814, Israel Rappaport Faculty of Medicine, Technion Institute of Technology, Haifa, Israel Electronic address
    Psychiatry Res 210:694-701. 2013
  3. ncbi request reprint The role of GABA-A receptor in the synergism between SSRI and antipsychotic in schizophrenia; implications for antipsychotic modes of actions
    Henry Silver
    Molecular Neuropsychiatry Unit, Brain Behavior Laboratory, Technion Faculty of Medicine, Haifa, Israel
    Curr Med Chem 20:363-70. 2013
  4. doi request reprint Impairment in associative memory in healthy aging is distinct from that in other types of episodic memory
    Henry Silver
    Sha ar Menashe Mental Health Center, Mobile Post Hefer, Israel
    Psychiatry Res 197:135-9. 2012
  5. ncbi request reprint Blood DHEAS concentrations correlate with cognitive function in chronic schizophrenia patients: a pilot study
    Henry Silver
    Brain Behavior Laboratory, Sha ar Menashe Mental Health Center, Mobile Post Hefer 38814, Israel
    J Psychiatr Res 39:569-75. 2005
  6. ncbi request reprint Evidence for sustained attention and working memory in schizophrenia sharing a common mechanism
    Henry Silver
    Sha ar Menashe Mental Health Center, and Director, Brain Behavior Laboratory, Mobile Post Hefer 38814, Israel
    J Neuropsychiatry Clin Neurosci 17:391-8. 2005
  7. ncbi request reprint A double-blind, cross-over comparison of the effects of amantadine or placebo on visuomotor and cognitive function in medicated schizophrenia patients
    Henry Silver
    Brain Behavior Laboratory, Sha ar Menashe Mental Health Center, Hadera, Israel
    Int Clin Psychopharmacol 20:319-26. 2005
  8. ncbi request reprint Impaired error monitoring contributes to face recognition deficit in schizophrenia patients
    Henry Silver
    Brain Behavior Laboratory, Sha ar Menashe Mental Health Center, Hadera, Israel
    Schizophr Res 85:151-61. 2006
  9. ncbi request reprint Impairment in error monitoring predicts poor executive function in schizophrenia patients
    Henry Silver
    Brain Behavior Laboratory, Sha ar Menashe Mental Health Center, Mobile Post Hefer, Israel
    Schizophr Res 94:156-63. 2007
  10. ncbi request reprint Suboptimal processing strategy and working-memory impairments predict abstraction deficit in schizophrenia
    Henry Silver
    Brain Behavior Laboratory, Sha ar Menashe Mental Health Center, Hadera, Israel
    J Clin Exp Neuropsychol 29:823-30. 2007

Collaborators

Detail Information

Publications43

  1. doi request reprint SSRI augmentation of antipsychotic alters expression of GABA(A) receptor and related genes in PMC of schizophrenia patients
    Henry Silver
    Molecular Neuropsychiatry Unit, Sha ar Menashe Brain Behavior Laboratory, Sha ar Menashe Mental Health Center, and Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    Int J Neuropsychopharmacol 14:573-84. 2011
    ..These changes may be part of the mechanism of clinically effective drug action and may prove to be biomarkers of pharmacological response...
  2. doi request reprint Pathways to similar executive impairment: comparison of schizophrenia patients and healthy aging individuals
    Henry Silver
    Brain Behavior Laboratory, Sha ar Menashe Mental Health Center, Mobile Post Hefer 38814, Israel Rappaport Faculty of Medicine, Technion Institute of Technology, Haifa, Israel Electronic address
    Psychiatry Res 210:694-701. 2013
    ..These constitute distinct targets for customized treatment in the two conditions. ..
  3. ncbi request reprint The role of GABA-A receptor in the synergism between SSRI and antipsychotic in schizophrenia; implications for antipsychotic modes of actions
    Henry Silver
    Molecular Neuropsychiatry Unit, Brain Behavior Laboratory, Technion Faculty of Medicine, Haifa, Israel
    Curr Med Chem 20:363-70. 2013
    ..In this paper, we review these studies and propose that modulation of the gamma-aminobutyric acid (GABA)-A receptor and its regulating system is the mechanism by which SSRI antipsychotic synergism exerts its clinical efficacy...
  4. doi request reprint Impairment in associative memory in healthy aging is distinct from that in other types of episodic memory
    Henry Silver
    Sha ar Menashe Mental Health Center, Mobile Post Hefer, Israel
    Psychiatry Res 197:135-9. 2012
    ..NAL may thus serve as a selective marker of complex, hippocampus-based, cognitive functions in studies of normal cognitive aging and of its possible relationship to early dementia...
  5. ncbi request reprint Blood DHEAS concentrations correlate with cognitive function in chronic schizophrenia patients: a pilot study
    Henry Silver
    Brain Behavior Laboratory, Sha ar Menashe Mental Health Center, Mobile Post Hefer 38814, Israel
    J Psychiatr Res 39:569-75. 2005
    ..The relationship was independent of the age related reduction in DHEAS levels. These preliminary results suggest that DHEAS may be associated with cognitive impairment in schizophrenia...
  6. ncbi request reprint Evidence for sustained attention and working memory in schizophrenia sharing a common mechanism
    Henry Silver
    Sha ar Menashe Mental Health Center, and Director, Brain Behavior Laboratory, Mobile Post Hefer 38814, Israel
    J Neuropsychiatry Clin Neurosci 17:391-8. 2005
    ....
  7. ncbi request reprint A double-blind, cross-over comparison of the effects of amantadine or placebo on visuomotor and cognitive function in medicated schizophrenia patients
    Henry Silver
    Brain Behavior Laboratory, Sha ar Menashe Mental Health Center, Hadera, Israel
    Int Clin Psychopharmacol 20:319-26. 2005
    ..Further studies of amantadine with different doses and treatment duration, as well as more glutamate selective agents such as memantine, are indicated...
  8. ncbi request reprint Impaired error monitoring contributes to face recognition deficit in schizophrenia patients
    Henry Silver
    Brain Behavior Laboratory, Sha ar Menashe Mental Health Center, Hadera, Israel
    Schizophr Res 85:151-61. 2006
    ..It has been proposed that social and cognitive deficits in schizophrenia may result from impaired error monitoring...
  9. ncbi request reprint Impairment in error monitoring predicts poor executive function in schizophrenia patients
    Henry Silver
    Brain Behavior Laboratory, Sha ar Menashe Mental Health Center, Mobile Post Hefer, Israel
    Schizophr Res 94:156-63. 2007
    ..Impaired ability to detect and correct errors may contribute to poor cognitive and social function in schizophrenia...
  10. ncbi request reprint Suboptimal processing strategy and working-memory impairments predict abstraction deficit in schizophrenia
    Henry Silver
    Brain Behavior Laboratory, Sha ar Menashe Mental Health Center, Hadera, Israel
    J Clin Exp Neuropsychol 29:823-30. 2007
    ..The model presented may enable differentiation between impaired and compensating components in schizophrenia patients with an abstraction deficit...
  11. doi request reprint Verbal as well as spatial working memory predicts visuospatial processing in male schizophrenia patients
    Henry Silver
    Brain Behavior Laboratory, Sha ar Menashe Mental Health Center, Mobile Post Hefer 38814, Israel
    Schizophr Res 101:210-7. 2008
    ..In this study we investigated the relationship among VSP, VWM and SWM...
  12. doi request reprint Analysis of cognitive performance in schizophrenia patients and healthy individuals with unsupervised clustering models
    Henry Silver
    Brain Behavior Laboratory, Sha ar Menashe Mental Health Center, Mobile Post Hefer 38814, Israel
    Psychiatry Res 159:167-79. 2008
    ..This preliminary study suggests that appropriate application of data-mining methods may contribute to investigation of cognitive functions...
  13. doi request reprint Multifunctional pharmacotherapy: what can we learn from study of selective serotonin reuptake inhibitor augmentation of antipsychotics in negative-symptom schizophrenia?
    Henry Silver
    Molecular Neuropsychiatry Unit, Brain Behavior Laboratory, Shaar Menashe Mental Health Center, and Technion Faculty of Medicine, Haifa 32000, Israel
    Neurotherapeutics 6:86-93. 2009
    ..Although as yet limited in scope, the findings of definable molecular targets for synergistic SSRI-antipsychotic interaction provide new directions to inform future research and provide novel bio-molecular targets for drug development...
  14. doi request reprint Age in high-functioning healthy men is associated with nonlinear decline in some 'executive' functions in late middle age
    Henry Silver
    Brain Behavior Laboratory, Sha ar Menashe Mental Health Center, Sha ar Menashe, Israel
    Dement Geriatr Cogn Disord 27:292-300. 2009
    ..Age-related cognitive decline might involve selective deterioration of specific brain systems. We studied the relationship between age and cognition by comparing cognitive function of older and younger high functioning men...
  15. doi request reprint 'Executive' functions and normal aging: selective impairment in conditional exclusion compared to abstraction and inhibition
    Henry Silver
    Brain Behavior Laboratory, Sha ar Menashe Mental Health Center, Mobile Post Hefer, Israel
    Dement Geriatr Cogn Disord 31:53-62. 2011
    ..Some executive functions may be selectively impaired in normal aging over and above the general cognitive decline...
  16. ncbi request reprint Schizophrenia patients with a history of severe violence differ from nonviolent schizophrenia patients in perception of emotions but not cognitive function
    Henry Silver
    Brain Behavior Laboratory, Sha ar Menashe Mental Health Center, Mobile Post Hefer 38814, Israel
    J Clin Psychiatry 66:300-8. 2005
    ..Impaired processing of emotions may relate to violent behavior in schizophrenia patients. We compared emotional function in schizophrenia patients with and without a history of severe violent behavior...
  17. ncbi request reprint Brief emotion training improves recognition of facial emotions in chronic schizophrenia. A pilot study
    Henry Silver
    Brain Behavior Laboratory Sha ar Menashe Mental Health Center, Mobile Post Hefer 38814, Israel
    Psychiatry Res 128:147-54. 2004
    ..This may be due to increased patient awareness of emotional aspects of stimuli and/or improvement in specific emotional perceptual skills. Further studies of Emotion Training as a potential treatment modality are warranted...
  18. ncbi request reprint Fluvoxamine as an adjunctive agent in schizophrenia
    H Silver
    Sha ar Menashe Mental Health Center, Rappaport Faculty of Medicine, Technion, Haifa, Israel
    CNS Drug Rev 7:283-304. 2001
    ..An important goal of future studies will be to define which patient groups can benefit from combined treatment...
  19. ncbi request reprint Perception of happy and sad facial expressions in chronic schizophrenia: evidence for two evaluative systems
    Henry Silver
    Flugelman Mazra Psychiatric Hospital, Doar Na Ashrat, Israel
    Schizophr Res 55:171-7. 2002
    ..Persons suffering from schizophrenia have impaired perception of emotional expressions, but it is not clear whether this is part of a generalized deficit in cognitive function...
  20. ncbi request reprint Impaired visuomotor function in schizophrenic patients compared with control subjects
    Henry Silver
    Flugelman Psychiatric Hospital, Mobile Post Ashrat, Israel
    J Neuropsychiatry Clin Neurosci 14:72-6. 2002
    ..The impairments were not related to medication dose or to extrapyramidal side effects. Visuomotor impairment may be part of illness-related pathology in schizophrenia...
  21. ncbi request reprint The onset and time course of response of negative symptoms to add-on fluvoxamine treatment
    Henry Silver
    Sha ar Menashe Mental Health Center, Hadera Rappaport Faculty of Medicine, Technion Institute of Technology, Haifa, Israel
    Int Clin Psychopharmacol 18:87-92. 2003
    ..Many symptoms, including those generally agreed to be core features of the illness such as alogia, improved within 2-3 weeks of treatment initiation...
  22. ncbi request reprint Working memory deficit as a core neuropsychological dysfunction in schizophrenia
    Henry Silver
    Brain Behavior Laaboratory, Sha ar Menashe Mental Health Center, Hadera, Israel
    Am J Psychiatry 160:1809-16. 2003
    ..This study tested the hypothesis that impaired working memory is a core deficit underlying multiple neuropsychological deficits in schizophrenia patients...
  23. ncbi request reprint Selective serotonin reuptake inhibitor augmentation in the treatment of negative symptoms of schizophrenia
    Henry Silver
    Sha ar Menashe Mental Health Center, Israel Rappaport Faculty of Medicine, Technion Institute of Technology, Haifa, Israel
    Int Clin Psychopharmacol 18:305-13. 2003
    ..Combination with clozapine may require particular caution because of potential toxicity if serum clozapine levels rise steeply. SSRI augmentation may be a useful addition to the treatment of schizophrenia...
  24. doi request reprint Impaired recognition of happy, sad and neutral expressions in schizophrenia is emotion, but not valence, specific and context dependent
    Henry Silver
    Brain Behavior Laboratory, Sha ar Menashe Mental Health Center, Hadera, Israel Bruce Rappaport Faculty of Medicine, Technion Institute of Technology, Haifa, Israel
    Psychiatry Res 169:101-6. 2009
    ..Processing of neutral expressions was context dependent. Emotion impairment in schizophrenia appears to be selective for the emotion domain but not specific emotions. Test context influences how neutral facial expressions are processed...
  25. ncbi request reprint Add-on fluvoxamine improves primary negative symptoms: evidence for specificity from response analysis of individual symptoms
    Henry Silver
    Brain Behavior Laboratory, Sha ar Menashe Mental Health Center, Mobile Post Hefer, Israel
    Schizophr Bull 29:541-6. 2003
    ..The findings support the view that fluvoxamine augmentation can improve primary negative symptoms in chronic schizophrenia patients...
  26. ncbi request reprint Perception of facial emotions in chronic schizophrenia does not correlate with negative symptoms but correlates with cognitive and motor dysfunction
    H Silver
    Flugelman Mazra Psychiatric Hospital, Doar Na Ashrat, Israel
    Schizophr Res 52:265-73. 2001
    ..We compared performance on tests of perception of facial emotions with that in other cognitive areas...
  27. ncbi request reprint Selective serotonin re-uptake inhibitor augmentation in the treatment of negative symptoms of schizophrenia
    Henry Silver
    Sha ar Menashe Mental Health Center, Mobile Post Hefer 38814, Israel
    Expert Opin Pharmacother 5:2053-8. 2004
    ..A better understanding of these mechanisms can shed light on the pathogenesis of negative symptoms and provide new targets for drug development...
  28. ncbi request reprint Fluvoxamine augmentation of antipsychotics improves negative symptoms in psychotic chronic schizophrenic patients: a placebo-controlled study
    H Silver
    Clinical Research Unit, Flugelman Mazra Psychiatric Hospital, Doar Na Ashrat Acco, Israel
    Int Clin Psychopharmacol 15:257-61. 2000
    ..The combination was well tolerated. Fluvoxamine augmentation of antipsychotics is safe in chronic schizophrenic patients with mixed positive and negative symptoms and may ameliorate negative symptoms in such patients...
  29. ncbi request reprint Decreased platelet peripheral-type benzodiazepine receptors in persistently violent schizophrenia patients
    Michael Ritsner
    Sha ar Menashe Mental Health Center, Mobile Post Hefer 38814, Israel
    J Psychiatr Res 37:549-56. 2003
    ....
  30. ncbi request reprint Negative attitude towards medication is associated with working memory impairment in schizophrenia patients
    Craig Goodman
    Brain Behavior Laboratory, Sha ar Menashe Mental Health Center, Hefer, Israel
    Int Clin Psychopharmacol 20:93-6. 2005
    ..Our findings support an association between negative attitudes towards medication and poor cognitive performance, particularly of working memory...
  31. ncbi request reprint Dopamine and serotonin metabolism in response to chronic administration of fluvoxamine and haloperidol combined treatment
    Y Chertkow
    Molecular Neuropsychiatry Unit, Shaar Menashe Brain Behavior Laboratory, Shaar Menashe MHC and Technion Faculty of Medicine, Haifa, Israel
    J Neural Transm 114:1443-54. 2007
    ..The possibility that these may be relevant to the mechanism underlying the clinical effectiveness of augmentation treatment warrant further study...
  32. ncbi request reprint Anhedonia and schizophrenia: how much is in the eye of the beholder?
    Henry Silver
    Flugelman Mazra Psychiatric Hospital, Doar Na Ashrat, Israel
    Compr Psychiatry 43:65-8. 2002
    ..Many schizophrenic patients may have a greater capacity to experience pleasure than is apparent to the people around them...
  33. ncbi request reprint Gene expression changes in peripheral mononuclear cells from schizophrenic patients treated with a combination of antipsychotic with fluvoxamine
    Yael Chertkow
    Molecular Neuropsychiatry Unit, Shaar Menashe Brain Behavior Laboratory, Shaar Menashe MHC, and Technion Faculty of Medicine, Haifa, Israel
    Prog Neuropsychopharmacol Biol Psychiatry 31:1356-62. 2007
    ..Our findings suggest that gene expression changes in PMC may be useful in investigating the mechanism of drug action in schizophrenia...
  34. ncbi request reprint The effect of chronic co-administration of fluvoxamine and haloperidol compared to clozapine on the GABA system in the rat frontal cortex
    Yael Chertkow
    Molecular Neuropsychiatry Unit, Shaar Menashe MHC, and Technion Faculty of Medicine, Haifa, Israel
    Int J Neuropsychopharmacol 9:287-96. 2006
    ..The present findings support the existence of a unique mechanism for SSRI-antipsychotic combination, different from that of the individual drugs and suggest that it may involve modification of the gamma aminobutyric acid (GABA) system...
  35. ncbi request reprint Insight into illness in schizophrenia
    Craig Goodman
    Brain Behavior Laboratory, Sha ar Menashe Mental Health Center, Mobile Post Hefer 38814, Israel
    Compr Psychiatry 46:284-90. 2005
    ..Our findings support an association between poor insight and cognitive impairment in patients with chronic schizophrenia but suggest that the relationship may not specifically involve frontal lobe dysfunction...
  36. ncbi request reprint Lymphocytes, autoantibodies and psychosis--coincidence versus etiological factor: an update
    M Schwartz
    Dept of Neurology, Bnai Zion Medical Center, Haifa, Israel
    Isr J Psychiatry Relat Sci 37:32-6. 2000
    ..These results suggest that schizophrenia may result from an immunologic disorder, which is mediated mainly (but probably not only) by lymphocyte dysfunction...
  37. doi request reprint Molecular mechanisms underlying synergistic effects of SSRI-antipsychotic augmentation in treatment of negative symptoms in schizophrenia
    Yael Chertkow
    Eve Topf Center of Excellence for Neurodegenerative Diseases Research, Department of Pharmacology, Technion Faculty of Medicine, Haifa, Israel
    J Neural Transm 116:1529-41. 2009
    ..While as yet limited in scope, the evidence suggests definable molecular targets which may be implicated in drug development based on SSRI-antipsychotic synergistic actions...
  38. ncbi request reprint The impact of side-effects of antipsychotic agents on life satisfaction of schizophrenia patients: a naturalistic study
    Michael Ritsner
    Institute for Psychiatric Studies, Sha ar Menashe Mental Health Center, Hadera, Israel
    Eur Neuropsychopharmacol 12:31-8. 2002
    ..Patient's subjective response to these events rather than their number is more predictive of QOL...
  39. ncbi request reprint Schizophrenic patients who smoke have a faster finger tapping rate than non-smokers
    Henry Silver
    Flugelman Mazra Psychiatric Hospital, Doar Na Ashrat, Israel
    Eur Neuropsychopharmacol 12:141-4. 2002
    ..Nicotine can improve central processing in medicated schizophrenia patients and this may constitute part of the incentive for smoking...
  40. ncbi request reprint Animal-assisted therapy ameliorates anhedonia in schizophrenia patients. A controlled pilot study
    Inbar Nathans-Barel
    Brain Behavior Laboratory, Sha ar Menashe Mental Health Center, Mobile Post Hefer, Haifa, Israel
    Psychother Psychosom 74:31-5. 2005
    ..We tested the hypothesis that animal-assisted therapy (AAT) may improve anhedonia...
  41. ncbi request reprint Fluvoxamine augmentation of olanzapine in chronic schizophrenia: pharmacokinetic interactions and clinical effects
    Christoph Hiemke
    Department of Psychiatry, University of Mainz, Germany
    J Clin Psychopharmacol 22:502-6. 2002
    ....
  42. ncbi request reprint Neuropsychological correlates of homocysteine levels in euthymic bipolar patients
    Yamima Osher
    Beer Sheva Mental Health Center, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
    J Affect Disord 105:229-33. 2008
    ..The current study was designed to extend this finding by examining the relationship between neuropsychological functioning and homocysteine levels in euthymic bipolar patients...
  43. ncbi request reprint Selective serotonin reuptake inhibitor add-on therapy for the negative symptoms of schizophrenia
    Henry Silver
    J Clin Psychiatry 69:163-4. 2008