G Rennert

Summary

Affiliation: Technion-Israel Institute of Technology
Country: Israel

Publications

  1. ncbi request reprint Are we taking the right approach in planning chemoprevention studies?
    Gad Rennert
    Department of Community Medicine and Epidemiology at Carmel Medical Center, Israel
    Nat Clin Pract Oncol 3:464-5. 2006
  2. ncbi request reprint The effect of bisphosphonates on the risk of endometrial and ovarian malignancies
    Gad Rennert
    Department of Community Medicine and Epidemiology, Carmel Medical Center and Bruce Rappaport Faculty of Medicine, Technion Israel Institute of Technology and Clalit Health Services National Cancer Control Center, Haifa, Israel Electronic address
    Gynecol Oncol 133:309-13. 2014
  3. pmc A case-control study of levothyroxine and the risk of colorectal cancer
    Gad Rennert
    Department of Community Medicine and Epidemiology, Carmel Medical Center, Haifa 34362, Israel
    J Natl Cancer Inst 102:568-72. 2010
  4. pmc Use of hormone replacement therapy and the risk of colorectal cancer
    Gad Rennert
    Department of Community Medicine and Epidemiology, Carmel Medical Center, 7 Michal St, Haifa 34362, Israel
    J Clin Oncol 27:4542-7. 2009
  5. ncbi request reprint Differences in the characteristics of families with BRCA1 and BRCA2 mutations in Israel
    G Rennert
    CHS National Familial Cancer Consultation Service, CHS National Cancer Control Center, Carmel Medical Center and Technion Faculty of Medicine, Haifa 34362, Israel
    Eur J Cancer Prev 14:357-61. 2005
  6. pmc Recreational physical activity modifies the association between a common GH1 polymorphism and colorectal cancer risk
    Sana Khoury-Shakour
    Clalit Health Services National Cancer Control Center, at Carmel Medical Center, Haifa 34362, Israel
    Cancer Epidemiol Biomarkers Prev 17:3314-8. 2008
  7. ncbi request reprint Diet and cancer: where are we and where are we going?
    Gad Rennert
    Department of Community Medicine and Epidemiology and CHS National Israeli Cancer Control Center, Carmel Medical Center and Technion Faculty of Medicine, Haifa 34362, Israel
    Proc Nutr Soc 62:59-62. 2003
  8. pmc Detecting K-ras mutations in stool from fecal occult blood test cards in multiphasic screening for colorectal cancer
    Gad Rennert
    Department of Community Medicine and Epidemiology, CHS National Cancer Control Center, Carmel Medical Center, Technion, Haifa 34362, Israel
    Cancer Lett 253:258-64. 2007
  9. ncbi request reprint Clinical outcomes of breast cancer in carriers of BRCA1 and BRCA2 mutations
    Gad Rennert
    Clalit Health Services, National Cancer Control Center and Department of Community Medicine and Epidemiology, Carmel Medical Center and B Rappaport Faculty of Medicine, Technion, Haifa, Israel
    N Engl J Med 357:115-23. 2007
  10. ncbi request reprint Colorectal polyps in carriers of the APC I1307K polymorphism
    Gad Rennert
    Department of Community Medicine and Epidemiology, CHS National Cancer Control Center, Carmel Medical Center and Technion Faculty of Medicine, Haifa, Israel
    Dis Colon Rectum 48:2317-21. 2005

Detail Information

Publications71

  1. ncbi request reprint Are we taking the right approach in planning chemoprevention studies?
    Gad Rennert
    Department of Community Medicine and Epidemiology at Carmel Medical Center, Israel
    Nat Clin Pract Oncol 3:464-5. 2006
  2. ncbi request reprint The effect of bisphosphonates on the risk of endometrial and ovarian malignancies
    Gad Rennert
    Department of Community Medicine and Epidemiology, Carmel Medical Center and Bruce Rappaport Faculty of Medicine, Technion Israel Institute of Technology and Clalit Health Services National Cancer Control Center, Haifa, Israel Electronic address
    Gynecol Oncol 133:309-13. 2014
    ..The use of bisphosphonates has been associated with reduced risk and improved survival of breast and colorectal malignancies. This study was aimed at studying the effects of bisphosphonates on gynecological cancers...
  3. pmc A case-control study of levothyroxine and the risk of colorectal cancer
    Gad Rennert
    Department of Community Medicine and Epidemiology, Carmel Medical Center, Haifa 34362, Israel
    J Natl Cancer Inst 102:568-72. 2010
    ..60, 95% confidence interval = 0.44 to 0.81, P = .001). No statistically significant interactions were seen between use of levothyroxine and aspirin, statins, or hormone replacement therapy...
  4. pmc Use of hormone replacement therapy and the risk of colorectal cancer
    Gad Rennert
    Department of Community Medicine and Epidemiology, Carmel Medical Center, 7 Michal St, Haifa 34362, Israel
    J Clin Oncol 27:4542-7. 2009
    ..Such treatments have formerly been shown to be associated with lower colorectal cancer risk in an as yet unknown mechanism...
  5. ncbi request reprint Differences in the characteristics of families with BRCA1 and BRCA2 mutations in Israel
    G Rennert
    CHS National Familial Cancer Consultation Service, CHS National Cancer Control Center, Carmel Medical Center and Technion Faculty of Medicine, Haifa 34362, Israel
    Eur J Cancer Prev 14:357-61. 2005
    ..Marked phenotypic differences were found between families carrying different BRCA mutations warranting mutation-specific counselling to families seeking risk-reduction advice. 5382insC emerged as a most aggressive mutation...
  6. pmc Recreational physical activity modifies the association between a common GH1 polymorphism and colorectal cancer risk
    Sana Khoury-Shakour
    Clalit Health Services National Cancer Control Center, at Carmel Medical Center, Haifa 34362, Israel
    Cancer Epidemiol Biomarkers Prev 17:3314-8. 2008
    ..We investigated the association of this polymorphism and physical activity with colorectal cancer risk in a case-control study...
  7. ncbi request reprint Diet and cancer: where are we and where are we going?
    Gad Rennert
    Department of Community Medicine and Epidemiology and CHS National Israeli Cancer Control Center, Carmel Medical Center and Technion Faculty of Medicine, Haifa 34362, Israel
    Proc Nutr Soc 62:59-62. 2003
    ....
  8. pmc Detecting K-ras mutations in stool from fecal occult blood test cards in multiphasic screening for colorectal cancer
    Gad Rennert
    Department of Community Medicine and Epidemiology, CHS National Cancer Control Center, Carmel Medical Center, Technion, Haifa 34362, Israel
    Cancer Lett 253:258-64. 2007
    ..Sequential detection of cancer-associated genetic markers from FOBT-based stool samples may potentially help separate true from false positives in a FOBT-based screening process...
  9. ncbi request reprint Clinical outcomes of breast cancer in carriers of BRCA1 and BRCA2 mutations
    Gad Rennert
    Clalit Health Services, National Cancer Control Center and Department of Community Medicine and Epidemiology, Carmel Medical Center and B Rappaport Faculty of Medicine, Technion, Haifa, Israel
    N Engl J Med 357:115-23. 2007
    ..We conducted a national population-based study of Israeli women to determine the influence, if any, of a BRCA1 or a BRCA2 mutation on the prognosis in breast cancer...
  10. ncbi request reprint Colorectal polyps in carriers of the APC I1307K polymorphism
    Gad Rennert
    Department of Community Medicine and Epidemiology, CHS National Cancer Control Center, Carmel Medical Center and Technion Faculty of Medicine, Haifa, Israel
    Dis Colon Rectum 48:2317-21. 2005
    ..The prevalence of polyps and adenomas in specimens of colorectal cancer who are carriers and noncarriers of the APC I1307K polymorphism is compared...
  11. ncbi request reprint Dietary intervention studies and cancer prevention
    G Rennert
    Department of Community Medicine and Epidemiology, CHS National Israeli Cancer Control Center, Technion Faculty of Medicine, Haifa 34362, Israel
    Eur J Cancer Prev 11:419-25. 2002
  12. doi request reprint Use of bisphosphonates and risk of postmenopausal breast cancer
    Gad Rennert
    Carmel Medical Center, Haifa, Israel
    J Clin Oncol 28:3577-81. 2010
    ..However, the association between the use of bisphosphonates and the risk of developing breast cancer has not been reported...
  13. pmc Use of bisphosphonates and reduced risk of colorectal cancer
    Gad Rennert
    Department of Community Medicine and Epidemiology, Carmel Medical Center, Bruce Rappaport Faculty of Medicine, Technion Israel Institute of Technology, and Clalit Health Services National Cancer Control Center, Haifa, Israel
    J Clin Oncol 29:1146-50. 2011
    ....
  14. ncbi request reprint Prevalence of selected chronic diseases in Israel
    G Rennert
    Clalit Health Services Headquarters, Tel Aviv, Israel
    Isr Med Assoc J 3:404-8. 2001
    ..Knowledge of the prevalence of chronic disease in the population is essential for health planners and providers...
  15. ncbi request reprint Population colorectal cancer screening with fecal occult blood test
    G Rennert
    Department of Community Medicine, Carmel Medical Center and Technion Faculty of Medicine, Haifa 34362, Israel
    Cancer Epidemiol Biomarkers Prev 10:1165-8. 2001
    ..Given its proven power to significantly reduce mortality, use of this test is strongly advised to both medical organizations and the healthy population at average risk...
  16. doi request reprint BRCA1 breast cancer risk is modified by CYP19 polymorphisms in Ashkenazi Jews
    Leon Raskin
    Clalit Health Services National Cancer Control Center, Carmel Medical Center, Haifa 34362, Israel
    Cancer Epidemiol Biomarkers Prev 18:1617-23. 2009
    ..The present study suggests that the CYP19 Val(80) polymorphism and a haplotype that includes this polymorphism are associated with increased breast cancer risk in young women with BRCA1 mutations...
  17. pmc Double heterozygosity in the BRCA1 and BRCA2 genes in the Jewish population
    O Lavie
    Division of Gynecology and Oncology, Carmel Medical Center and B Rappaport Faculty of Medicine, Technion, Haifa, Israel
    Ann Oncol 22:964-6. 2011
    ..The frequency and characteristics of disease in individuals who concomitantly harbor pathogenic mutations in both BRCA1 and BRCA2 genes are not established...
  18. ncbi request reprint Proband family uptake of familial-genetic counselling
    L Hagoel
    Clalit Health Services, National Cancer Control Center at Carmel Medical Center, Haifa, Israel
    Psychooncology 9:522-7. 2000
    ....
  19. doi request reprint Smoking attenuates the negative association between carotenoids consumption and colorectal cancer risk
    Y Chaiter
    Department of Community Medicine and Epidemiology, CHS National Cancer Control Center, Carmel Medical Center and B Rappaport Faculty of Medicine, Technion, Israel Institute of Technology, 7 Michal St, 34362, Haifa, Israel
    Cancer Causes Control 20:1327-38. 2009
    ..The association between dietary intake of carotenoids from vegetables/fruits and risk of CRC in the context of cigarette smoking was studied in a nutritionally diverse population...
  20. doi request reprint Genetic variation in IGF-1 and breast cancer risk in Ashkenazi carriers and noncarriers of BRCA1/2 mutations
    Sana Khoury-Shakour
    Department of Community Medicine and Epidemiology and CHS National Cancer Control Center, Carmel Medical Center and B Rappaport Faculty of Medicine, Technion, Haifa, Israel
    Eur J Cancer Prev 18:361-7. 2009
    ..The IGF-1 gene seems to be associated with breast cancer risk in premenopausal Ashkenazi Jewish women who are not carriers of mutations in BRCA1/2 genes...
  21. pmc Spontaneous and therapeutic abortions and the risk of breast cancer among BRCA mutation carriers
    Eitan Friedman
    The Suzanne Levy Gertner Oncogenetics Unit, The Chaim Sheba Medical Center, Tel Hashomer, Israel, and the Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
    Breast Cancer Res 8:R15. 2006
    ....
  22. doi request reprint The relationship between obesity and the increase in serum 25(OH)D levels in response to vitamin D supplementation
    W Saliba
    Department of Community Medicine and Epidemiology, Carmel Medical Center, Clalit Health Services, and Bruce Rappaport Faculty of Medicine, Technion Israel Institute of Technology, 7 Michal St, Haifa, 34362, Israel
    Osteoporos Int 24:1447-54. 2013
    ..This study revealed that the increase in serum 25(OH)D in response to vitamin D supplementation was higher in lean subjects as compared to obese subjects...
  23. doi request reprint Serum 25(OH)D concentrations in sunny Israel
    W Saliba
    Department of Community Medicine and Epidemiology, Carmel Medical Center, Clalit Health Services, and Bruce Rappaport Faculty of Medicine, Technion Israel Institute of Technology, 7 Michal St, Haifa 34362, Israel
    Osteoporos Int 23:687-94. 2012
    ..Serum 25(OH)D levels <25 and <50 nmol/L are common in Israel with noted differences between Arabs and Jews, Arab females were particularly at high risk. These findings may require public health intervention at the population level...
  24. ncbi request reprint Screening with faecal occult blood test (FOBT) for colorectal cancer: assessment of two methods that attempt to improve compliance
    L Ore
    Department of Community Medicine and Epidemiology, Carmel Medical Center and the Faculty of Medicine, Technion, Haifa, Israel
    Eur J Cancer Prev 10:251-6. 2001
    ..9%) in the level of compliance for the relatively low cost of postage. More effort is needed to study additional means of convincing the non-responders to take part in this potentially life saving activity...
  25. ncbi request reprint BRCA germline mutations in Jewish women with uterine serous papillary carcinoma
    Ofer Lavie
    Division of Gynecologic Oncology, Carmel Medical Center, Haifa 34362, Israel
    Gynecol Oncol 92:521-4. 2004
    ..The purpose of this study was to determine the incidence of these mutations in an enlarged series of USPC...
  26. doi request reprint The risk of developing uterine sarcoma after tamoxifen use
    O Lavie
    Department of Obstetrics and Gynecology, Division of Gynecology and Oncology, Carmel Medical Center, Haifa, Israel
    Int J Gynecol Cancer 18:352-6. 2008
    ..08). We conclude that in this national breast cancer cohort, tamoxifen use was associated with elevated risks of uterine cancer incidence and mortality. Uterine sarcomas appear to be overrepresented among women who use tamoxifen...
  27. doi request reprint Single measurement of serum 25(OH)D: is classification into month-specific cutpoints useful in accounting for seasonal variation?
    W Saliba
    Department of Community Medicine and Epidemiology, Carmel Medical Center, Clalit Health Services, and Bruce Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    Eur J Clin Nutr 66:1069-71. 2012
    ..The month-specific cutpoint strategy does not seem to offer advantage over the overall cutpoints strategy...
  28. ncbi request reprint Utilization of K-ras mutations identified in stool DNA for the early detection of colorectal cancer
    Z Lev
    Department of Biology, Technion Israel Institute of Technology, Haifa
    J Cell Biochem Suppl 34:35-9. 2000
    ..As such they should be very effective when used in chemoprevention studies and screening protocols for colorectal cancer...
  29. doi request reprint Quality control in a National Program for the Early Detection of Breast Cancer: women's satisfaction with the mammography process
    Ronit Almog
    Department of Community Medicine and Epidemiology, Carmel Medical Center, The Faculty of Medicine, Technion, Haifa, Israel
    Womens Health Issues 18:110-7. 2008
    ..The study goal was to assess women's overall satisfaction with the mammography examination service provided by participating units in the National Program for the Early Detection of Breast Cancer in Israel...
  30. doi request reprint Gynecologic malignancies in Ashkenazi families with the MSH2 A636P founder mutation
    Ofer Lavie
    Division of Gynecology and Oncology, Carmel Medical Center, B Rappaport Faculty of Medicine, Technion, Haifa, Israel
    Am J Obstet Gynecol 199:148.e1-3. 2008
    ..Although the incidence of colorectal cancer in carriers is relatively well established, the frequency of other tumors is less clear...
  31. doi request reprint The public prefers fecal occult blood test over colonoscopy for colorectal cancer screening
    Ronit Almog
    Department of Community Medicine and Epidemiology, Clalit Health Services Cancer Control Center at Carmel Medical Center and The Faculty of Medicine, Technion, Haifa, Israel
    Eur J Cancer Prev 17:430-7. 2008
    ..6-3.0)], and with a more negative one toward FOBT [OR: 0.4 (95% CI: 0.3-0.7)]. Target population preferences for CRC screening supports a policy of FOBT screening for an average risk population and colonoscopy for high-risk individuals...
  32. ncbi request reprint Clustering women's health behaviors
    Lea Hagoel
    Department of Community Medicine and Epidemiology, Carmel Medical Center and the Faculty of Medicine, Technion, Haifa, Israel
    Health Educ Behav 29:170-82. 2002
    ..The concept of lifestyle was deemed appropriate to summarize the clustering of these behavioral, perceptual, and structural variables...
  33. ncbi request reprint BRCA1/2 mutation carriers: living with susceptibility
    Lea Hagoel
    Department of Community Medicine and Epidemiology, Carmel Medical Center, Technion, Haifa, Israel
    Community Genet 6:242-8. 2003
    ..To examine whether being a BRCA1/2 mutation carrier affects a wide array of aspects of life, and if so, how...
  34. doi request reprint Fecal occult blood test performance indicators in warfarin-treated patients
    Anne Kershenbaum
    Department of Community Medicine and Epidemiology, Carmel Medical Center and B Rappaport Faculty of Medicine, Clalit Health Services National Cancer Control Center, Haifa, Israel
    Dis Colon Rectum 53:224-9. 2010
    ..Antithrombotic drugs such as warfarin cause a general increase in bleeding tendency and therefore could influence fecal occult blood test results...
  35. ncbi request reprint Maternal mosaicism for a second mutational event--a novel deletion--in a familial adenomatous polyposis family harboring a new germ-line mutation in the alternatively spliced-exon 9 region of APC
    Sima Davidson
    Molecular Oncology Laboratory, Rambam Medical Center, Haifa, Israel
    Hum Mutat 19:83-4. 2002
    ..Our study is only the second report of parental mosaicism in the APC gene...
  36. ncbi request reprint Fecal occult blood screening--trial evidence, practice and beyond
    Gad Rennert
    Department of Community Medicine and Epidemiology, Carmel Medical Center and Technion Faculty of Medicine, Haifa 34362, Israel
    Recent Results Cancer Res 163:248-53; discussion 264-6. 2003
    ..Multiple policymakers are already recommending this procedure for routine screening of average risk population. Taking their recommendations into action is of major importance...
  37. ncbi request reprint Calcium intake and bone mass development among Israeli adolescent girls
    G S Rozen
    Department of Diet and Nutrition, Rambam Medical Center, Haifa, Israel
    J Am Coll Nutr 20:219-24. 2001
    ..To determine the possible relationship between food and life style habits and bone health in adolescent Israeli females...
  38. ncbi request reprint Dietary intake of carotenoid isomers in Israel
    Yoram Chaiter
    Department of Community Medicine and Epidemiology, CHS National Cancer Control Center, Carmel Medical Center, 7 Michal St, Haifa, Israel
    Int J Vitam Nutr Res 77:398-405. 2007
    ..Consumption in Israel seems to be generally higher than that reported in studies conducted elsewhere, and varies by ethnic group...
  39. ncbi request reprint BRCA2 germline mutation in a woman with uterine serous papillary carcinoma--case report
    Ofer Lavie
    Division of Gynecological Oncology, Carmel Medical Center, 7 Michal Street, Haifa 34362, Israel
    Gynecol Oncol 99:486-8. 2005
    ..Recently, a high incidence of BRCA1 cancer predisposing mutation was described among patients with Uterine Serous Papillary Carcinoma (USPC). A BRCA2 germline mutation in a USPC patient has never been reported...
  40. ncbi request reprint Ethnic differences in the epidemiological characteristics of severe trauma due to falls from heights among children in northern Israel
    Naomi Bar-Joseph
    Pediatric Intensive Care Unit, Meyer Children s Hospital, Rambam Medical Center, Haifa, Israel
    Isr Med Assoc J 9:603-6. 2007
    ..Road accidents constitute the most frequent cause of mortality among children older than 1 year and falls from heights are the most frequent cause of injuries requiring hospitalization...
  41. ncbi request reprint Neurobehavioral and cognitive performances of children exposed to low-dose radiation in the Chernobyl accident: the Israeli Chernobyl Health Effects Study
    N Bar Joseph
    CHS National Cancer Control Center and Department of Community Medicine and Epidemiology, Carmel Medical Center, Haifa 34362, Israel
    Am J Epidemiol 160:453-9. 2004
    ..There is a possible behavioral effect among offspring of pregnant mothers or mothers of very young children in all exposure levels...
  42. ncbi request reprint Ciliary ultrastructure in primary ciliary dyskinesia and other chronic respiratory conditions: the relevance of microtubular abnormalities
    M Lurie
    Department of Pathology, Carmel Hospital, Technion Medical School, Haifa, Israel
    Ultrastruct Pathol 16:547-53. 1992
    ..Ciliary microtubular abnormalities of any kind were no more frequent in cases of primary ciliary dyskinesia than in other cases. The same was true for transposition and radial spoke defects...
  43. ncbi request reprint Prevention and early detection of colorectal cancer--new horizons
    Gad Rennert
    CHS National Cancer Control Center, Carmel Medical Center, Haifa, Israel
    Recent Results Cancer Res 174:179-87. 2007
    ..With all of these developments taking place, the near future will undoubtedly bring about the expected reduction in colorectal cancer mortality...
  44. ncbi request reprint Political interpretation of scientific evidence--case study of breast cancer screening policies around the world
    Gad Rennert
    Department of Community Medicine and Epidemiology, Carmel Medical Center and Technion Faculty of Medicine, Haifa 34362, Israel
    Recent Results Cancer Res 163:140-8; discussion 264-6. 2003
    ..Inherent differences between the countries in structure of the health system, in the commitment to public health activities, and in opinions and health habits of the relevant populations may explain these different outcomes...
  45. doi request reprint The use of exercise stress testing for the management of low-risk patients with chest pain
    Asia Kogan
    Emergency Department, Carmel Medical Center, Haifa 34362, Israel
    Am J Emerg Med 27:889-92. 2009
    ..This retrospective study assessed the contribution of exercise stress testing (EST) in the evaluation of patients with low risk for coronary heart disease who presented to the emergency department (ED) with chest pain...
  46. ncbi request reprint Vascular disorders preceding diagnosis of cancer: distinguishing the causal relationship based on Bradford-Hill guidelines
    Jochanan E Naschitz
    Department of Internal Medicine A, Bnai Zion Medical Center, Haifa, Israel
    Angiology 54:11-7. 2003
    ..In conclusion, these data support the causal role of cancer in the pathogenesis of all seven categories of VDPCDs. Recognition of such a causal link between cancer and various vascular disorders may promote an earlier cancer diagnosis...
  47. ncbi request reprint Effect of pregnancy as a risk factor for breast cancer in BRCA1/BRCA2 mutation carriers
    Carey A Cullinane
    City of Hope National Medical Center, Duarte, CA, USA
    Int J Cancer 117:988-91. 2005
    ..Among BRCA2 carriers, increasing parity was associated with a significant increase in the risk of breast cancer before age 50 and this increase was greatest in the 2-year period following a pregnancy...
  48. ncbi request reprint RNASEL mutation screening and association study in Ashkenazi and non-Ashkenazi prostate cancer patients
    Avi Orr-Urtreger
    Genetic Institute, Tel Aviv Sourasky Medical Center, 6 Weizmann Street, 64239 Tel Aviv, Israel
    Cancer Epidemiol Biomarkers Prev 15:474-9. 2006
    ..Taken together, our analysis does not support a role for the RNASEL 471delAAAG Ashkenazi mutation nor for the other alterations detected in RNASEL in prostate cancer risk in Jewish men...
  49. ncbi request reprint Oral contraceptives and the risk of breast cancer in BRCA1 and BRCA2 mutation carriers
    Steven A Narod
    The Centre for Research on Women s Health, University of Toronto, 790 Bay Street, Toronto, Ontario M5G 1N8, Canada
    J Natl Cancer Inst 94:1773-9. 2002
    ..We examined whether this association is seen in women at high risk of breast cancer because they carry a mutation in one of two breast cancer susceptibility genes, BRCA1 and BRCA2...
  50. ncbi request reprint BLM heterozygosity and the risk of colorectal cancer
    Stephen B Gruber
    Departments of Internal Medicine and Epidemiology, University of Michigan, Ann Arbor, MI 48109, USA
    Science 297:2013. 2002
  51. ncbi request reprint K-ras mutations in sporadic colorectal tumors in Israel: unusual high frequency of codon 13 mutations and evidence for nonhomogeneous representation of mutation subtypes
    Dmitry Kislitsin
    Department of Biology, Technion Israel Institute of Technology, Haifa
    Dig Dis Sci 47:1073-9. 2002
    ..The heterogeneous distribution found may be due to a variable genetic background and different environmental factors involved in the initiation and propagation of sporadic colorectal cancer...
  52. ncbi request reprint APC I1307K and the risk of prostate cancer
    Jenny N Poynter
    Division of Molecular Medicine and Genetics, University of Michigan, 4301 MSRB III, Ann Arbor, MI 48109 0638, USA
    Cancer Epidemiol Biomarkers Prev 15:468-73. 2006
    ..Overall, the evidence for an association between APC I1307K and prostate cancer is not compelling. APC I1307K is unlikely to play a clinically meaningful role in susceptibility to prostate cancer...
  53. ncbi request reprint CDX2 polymorphisms, RNA expression, and risk of colorectal cancer
    Laura S Rozek
    Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan 48109 0638, USA
    Cancer Res 65:5488-92. 2005
    ....
  54. ncbi request reprint Fecal DNA biomarkers for the detection of colorectal neoplasia: attractive, but is it feasible?
    Dean E Brenner
    J Natl Cancer Inst 97:1107-9. 2005
  55. pmc Hormone therapy and the risk of breast cancer in BRCA1 mutation carriers
    Andrea Eisen
    Sunnybrook Regional Cancer Center, Toronto, Ontario, Canada
    J Natl Cancer Inst 100:1361-7. 2008
    ....
  56. doi request reprint FGFR2 is a breast cancer susceptibility gene in Jewish and Arab Israeli populations
    Leon Raskin
    Department of of Internal Medicine, University of Michigan Medical School and School of Public Health, Ann Arbor, MI 48109, USA
    Cancer Epidemiol Biomarkers Prev 17:1060-5. 2008
    ..The identification of population-specific risk haplotypes in FGFR2 is likely to help identify causal variants for breast cancer...
  57. ncbi request reprint The MLH1 D132H variant is associated with susceptibility to sporadic colorectal cancer
    Steven M Lipkin
    Division of Oncology, Department of Medicine, University of California, Irvine, Irvine, California 92697, USA
    Nat Genet 36:694-9. 2004
    ..These studies suggest that variants of mismatch repair proteins with attenuated function may account for a higher proportion of susceptibility to sporadic microsatellite-stable CRC than previously assumed...
  58. ncbi request reprint Statins and the risk of colorectal cancer
    Jenny N Poynter
    Department of Epidemiology, University of Michigan, Ann Arbor 48109 0638, USA
    N Engl J Med 352:2184-92. 2005
    ..Statins inhibit the growth of colon-cancer cell lines, and secondary analyses of some, but not all, clinical trials suggest that they reduce the risk of colorectal cancer...
  59. ncbi request reprint Age at first birth and the risk of breast cancer in BRCA1 and BRCA2 mutation carriers
    Joanne Kotsopoulos
    Centre for Research in Women s Health, Women s College Hospital, University of Toronto, Room 750, 790 Bay Street, 7th Floor, Toronto, ON M5G 1N8, Canada
    Breast Cancer Res Treat 105:221-8. 2007
    ..Nonetheless, BRCA mutation carriers opting for a prophylactic oophorectomy as a breast and/or ovarian cancer risk-reducing strategy should complete childbearing prior to age 40 when this prevention modality is most effective...
  60. ncbi request reprint Network modeling links breast cancer susceptibility and centrosome dysfunction
    Miguel Angel Pujana
    Center for Cancer Systems Biology CCSB, Dana Farber Cancer Institute and Department of Genetics, Harvard Medical School, 44 Binney St, Boston, Massachusetts 02115, USA
    Nat Genet 39:1338-49. 2007
    ..Our network modeling strategy should be useful for the discovery of additional cancer-associated genes...
  61. pmc RAD51 135G-->C modifies breast cancer risk among BRCA2 mutation carriers: results from a combined analysis of 19 studies
    Antonis C Antoniou
    Cancer Research UK, Genetic Epidemiology Unit, Strangeways Research Laboratory, Cambridge, CB1 8RN, UK
    Am J Hum Genet 81:1186-200. 2007
    ..Thus, 135G-->C may modify the risk of breast cancer in BRCA2 mutation carriers by altering the expression of RAD51. RAD51 is the first gene to be reliably identified as a modifier of risk among BRCA1/2 mutation carriers...
  62. ncbi request reprint Clinical phenotype of families with longevity
    Gil Atzmon
    Institute for Aging Research, Diabetes Research and Training Center, Department of Medicine, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Am Geriatr Soc 52:274-7. 2004
    ..To determine whether offspring of centenarians acquired protection from age-related diseases...
  63. ncbi request reprint BRCA1 and BRCA2 founder mutations and the risk of colorectal cancer
    Bethany L Niell
    Department of Internal Medicine, Division of Molecular Medicine and Genetics, University of Michigan Medical School, Ann Arbor, MI 48109 0638, USA
    J Natl Cancer Inst 96:15-21. 2004
    ..We investigated BRCA1/2 founder mutations and a family history of breast cancer as potential risk factors for colorectal cancer...
  64. pmc Common breast cancer-predisposition alleles are associated with breast cancer risk in BRCA1 and BRCA2 mutation carriers
    Antonis C Antoniou
    Cancer Research UK, Genetic Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, UK
    Am J Hum Genet 82:937-48. 2008
    ....
  65. ncbi request reprint APC E1317Q is not associated with Colorectal Cancer in a population-based case-control study in Northern Israel
    Laura S Rozek
    Division of Molecular Medicine and Genetics, University of Michigan, 1524 BSRB, 109 Zina Pitcher, Box 2200, Ann Arbor, MI 48109 2200, USA
    Cancer Epidemiol Biomarkers Prev 15:2325-7. 2006
    ..Given the substantial size of our study and the consistency of our findings with the results of our meta-analyses, we conclude that it is unlikely that APC E1317Q is associated with a clinically meaningful risk of colorectal cancer...
  66. pmc Genetic anthropology of the colorectal cancer-susceptibility allele APC I1307K: evidence of genetic drift within the Ashkenazim
    Bethany L Niell
    Department of Internal Medicine, Division of Molecular Medicine and Genetics, University of Michigan Medical School, Ann Arbor, MI 48109 0638, USA
    Am J Hum Genet 73:1250-60. 2003
    ..This research underscores the importance of the migratory patterns of ancestral populations in the ethnic and geographic distribution of APC I1307K...
  67. ncbi request reprint Phenotype of microsatellite unstable colorectal carcinomas: Well-differentiated and focally mucinous tumors and the absence of dirty necrosis correlate with microsatellite instability
    Joel K Greenson
    Department of Pathology, Universit of Michigan Health System, Ann Arbor, 48109, USA
    Am J Surg Pathol 27:563-70. 2003
    ..The combination of >2 tumor infiltrating lymphocytes per high power field and/or any mucinous differentiation and/or the absence of dirty necrosis identified all MSI-H tumors in this study...
  68. pmc A novel founder mutation in the RNASEL gene, 471delAAAG, is associated with prostate cancer in Ashkenazi Jews
    Hanna Rennert
    Genetic Institute, Tel Aviv Sourasky Medical Center, Israel
    Am J Hum Genet 71:981-4. 2002
    ..However, additional studies are required to determine whether this mutation confers increased risk for PRCA in this population...
  69. pmc Genome-wide association scan identifies a colorectal cancer susceptibility locus on 11q23 and replicates risk loci at 8q24 and 18q21
    Albert Tenesa
    Colon Cancer Genetics Group, Institute of Genetics and Molecular Medicine, University of Edinburgh and MRC Human Genetics Unit, Edinburgh EH4 2XU, UK
    Nat Genet 40:631-7. 2008
    ..008) and rs4939827 (P < 0.009). Carrying all six possible risk alleles yielded OR = 2.6 (95% CI = 1.75-3.89) for CRC. These findings extend our understanding of the role of common genetic variation in CRC etiology...
  70. ncbi request reprint Cancer prevention: from public health interventions to individual tailoring
    Gad Rennert
    Eur J Cancer Prev 16:165-6. 2007
  71. pmc Accurate molecular classification of human cancers based on gene expression using a simple classifier with a pathological tree-based framework
    Kerby A Shedden
    Department of Statistics, University of Michigan, Ann Arbor, MI 48109 1027, USA
    Am J Pathol 163:1985-95. 2003
    ..Our findings suggest that accurate and robust cancer diagnosis from gene expression profiles can be achieved by mimicking the classification strategies routinely used by surgical pathologists...