Research Topics
Genomes and Genes | Gera NeufeldSummaryAffiliation: Technion-Israel Institute of Technology Country: Israel Publications
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Detail Information
Publications
Semaphorins in angiogenesis and tumor progressionGera Neufeld
Cancer and Vascular Biology Research Center, Rappaport Research Institute in the Medical Sciences, Bruce Rappaport Faculty of Medicine, Technion, Israel Institute of Technology, Haifa 31096, Israel
Cold Spring Harb Perspect Med 2:a006718. 2012..Furthermore, loss of endogenous inhibitory semaphorin expression or function on one hand, and overexpression of protumorigenic semaphorins on the other hand, is associated with the progression of some tumor types...
Vascular endothelial growth factor (VEGF) and its receptorsG Neufeld
Department of Biology, Technion, Israel Institute of Technology, Technion City, Haifa 32000, Israel
FASEB J 13:9-22. 1999....- Pro-angiogenic cytokines and their role in tumor angiogenesisGera Neufeld
Cancer and Vascular Biology Research Center, Rappaport Research Institute in the Medical Sciences, The Bruce Rappaport Faculty of Medicine, Technion, Israel Institute of Technology, 1 Efron St, P O Box 9679, Haifa 31096, Israel
Cancer Metastasis Rev 25:373-85. 2006..Indeed, the first FDA approved anti-angiogenic drug for the treatment of cancer is Avastin, a neutralizing antibody directed against VEGF. This review focuses on cytokines which have been reported to induce tumor angiogenesis... 
The semaphorins: versatile regulators of tumour progression and tumour angiogenesisGera Neufeld
Cancer Research and Vascular Biology Center, The Bruce Rappaport Faculty of Medicine, Technion, Israel Institute of Technology, P O Box 9679, 1 Efron Street, Haifa, 31096, Israel
Nat Rev Cancer 8:632-45. 2008..This Review focuses on the emerging role of the semaphorins in cancer...- Semaphorin signaling in vascular and tumor biologyGera Neufeld
Cancer and Vascular Biology Research Center, Rappaport Research Institute in the Medical Sciences, The Bruce Rappaport Faculty of Medicine, Technion, Israel Institute of Technology, 1 Efron St, P O Box 9679, Haifa, 31096, Israel
Adv Exp Med Biol 600:118-31. 2007..In this chapter we cover recent developments in this rapidly developing field of research... - The interaction of Neuropilin-1 and Neuropilin-2 with tyrosine-kinase receptors for VEGFGera Neufeld
Department of Biology, Technion, Israel Institute of Technology, Haifa, 32000, Israel
Adv Exp Med Biol 515:81-90. 2002..In contrast, it was recently reported by two laboratories that Neuropilins can form complexes with the second tyrosine-kinase receptor of VEGF, VEGFR1. However, the biological function of these complexes is still unclear... - Successful inhibition of tumor development by specific class-3 semaphorins is associated with expression of appropriate semaphorin receptors by tumor cellsBoaz Kigel
Cancer Research and Vascular Biology Center, The Bruce Rappaport Faculty of Medicine, Technion, Israel Institute of Technology, Haifa, Israel
PLoS ONE 3:e3287. 2008..Our results suggest that combinations of different class-3 semaphorins may be more effective than single semaphorins in cases in which tumor cells express more than one type of semaphorin receptors... - Semaphorin-3A and semaphorin-3F work together to repel endothelial cells and to inhibit their survival by induction of apoptosisNoga Guttmann-Raviv
Cancer and Vascular Biology Research Center, Rappaport Research Institute in the Medical Sciences, The Bruce Rappaport Faculty of Medicine, Technion, Israel Institute of Technology, Haifa 31096, Israel
J Biol Chem 282:26294-305. 2007..These observations suggest that combinations of sema3A and sema3F may be able to inhibit tumor angiogenesis more effectively than single semaphorins... - Semaphorins in cancerGera Neufeld
Cancer and Vascular Biology Research Center, Rappaport Research Institute in the Medical Sciences, The Bruce Rappaport Faculty of Medicine, Technion, Israel Institute of Technology, Haifa, Israel
Front Biosci 10:751-60. 2005..In this review we discuss the semaphorins, their receptors and their signal transduction mechanisms, and evidence linking semaphorins to the control of tumorigenesis and tumor progression... - Semaphorin-3F is an inhibitor of tumor angiogenesisOfra Kessler
Department of Cell Biology and Anatomy, Rappaport Family Institute for Research in the Medical Sciences, The Bruce Rappaport Faculty of Medicine, Technion, Israel Institute of Technology, Haifa, Israel
Cancer Res 64:1008-15. 2004..The tumors that did develop from s3f-expressing HEK293 cells developed at a much slower rate and had a significantly lower concentration of tumor-associated blood vessels, indicating that s3f is an inhibitor of tumor angiogenesis... - Abnormal deposition of collagen around hepatocytes in Wilson's disease is associated with hepatocyte specific expression of lysyl oxidase and lysyl oxidase like protein-2Zehava Vadasz
The Bruce Rappaport Faculty of Medicine, Cancer and Vascular Biology Research Center, Rappaport Family Institute for Research in the Medical Sciences, Technion, Israel Institute of Technology, P O Box 9697, 1 Efron St, 31096 Haifa, Israel
J Hepatol 43:499-507. 2005..Lysyl-oxidases catalyze the oxidation of lysine residues in collagen and elastin thereby promoting their polymerization. We have studied here the expression of four lysyl-oxidases in normal and diseased human liver... - Plexin-A4 promotes tumor progression and tumor angiogenesis by enhancement of VEGF and bFGF signalingBoaz Kigel
Cancer and Vascular Biology Research Center, Rappaport Research Institute in the Medical Sciences, The Bruce Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
Blood 118:4285-96. 2011..Our results suggest that plexin-A4 may represent a target for the development of novel anti-angiogenic and anti-tumorigenic drugs... - The neuropilins and their role in tumorigenesis and tumor progressionNoga Guttmann-Raviv
Cancer and Vascular Biology Research Center, Rappaport Research Institute in the Medical Sciences, The Bruce Rappaport Faculty of Medicine, Technion, Israel Institute of Technology, 1 Efron St, P.O. Box 9679, Haifa 31096, Israel
Cancer Lett 231:1-11. 2006.... - The neuropilins: multifunctional semaphorin and VEGF receptors that modulate axon guidance and angiogenesisGera Neufeld
Department of Biology, Technion, Israel Institute of Technology, Haifa, Israel
Trends Cardiovasc Med 12:13-9. 2002..This review focuses on the neuropilins, their interactions, and their biological roles in the nervous and cardiovascular systems... - Receptor activity modifying protein-3 mediates the protumorigenic activity of lysyl oxidase-like protein-2Vera Brekhman
Cancer Research and Vascular Biology Center, The Bruce Rappaport Faculty of Medicine, Technion, Israel Institute of Technology, Haifa, 31096, Israel
FASEB J 25:55-65. 2011..Our experiments suggest that the protumorigenic effects of LOXL2 are partially mediated by RAMP3 and that RAMP3 inhibitors may function as antitumorigenic agents. -.. - The enzymatic activity of lysyl oxidas-like-2 (LOXL2) is not required for LOXL2-induced inhibition of keratinocyte differentiationJennie Lugassy
Cancer and Vascular Biology Research Center, Bruce Rappaport Faculty of Medicine, Technion, Israel Institute of Technology, Haifa 31096, Israel
J Biol Chem 287:3541-9. 2012..Our results suggest that agents that inhibit the enzymatic activity of LOXL2 may not suffice to inhibit completely the effects of LOXL2 on complex processes that involve altered states of cellular differentiation... - Neuropilin-1 and neuropilin-2 enhance VEGF121 stimulated signal transduction by the VEGFR-2 receptorNiva Shraga Heled
Cancer and Vascular Biology Research Center, Rappaport Research Institute in the Medical Sciences, Bruce Rappoport Faculty of Medicine, Technion, Israel Institute of Technology, Haifa 31096, Israel
FASEB J 21:915-26. 2007.... - Semaphorin-3B is an angiogenesis inhibitor that is inactivated by furin-like pro-protein convertasesAsya Varshavsky
Cancer and Vascular Biology Research Center, Rappaport Research Institute in the Medical Sciences, The Bruce Rappaport Faculty of Medicine, Technion, Israel Institute of Technology, Haifa, Israel
Cancer Res 68:6922-31. 2008..These results suggest that up-regulation of furin-like pro-protein convertases in malignant cells may enable tumors to evade the antiangiogenic effects of sema3B... - VEGF162, a new heparin-binding vascular endothelial growth factor splice form that is expressed in transformed human cellsTali Lange
Department of Cell Biology and Anatomy, The Bruce Rappaport Faculty of Medicine, Technion, Israel Institute of Technology, PO Box 9697, 1 Efron Street, Haifa 31096, Israel
J Biol Chem 278:17164-9. 2003.... - Neuropilin-2 is a novel marker expressed in pancreatic islet cells and endocrine pancreatic tumoursTzafra Cohen
Department of Pathology, Carmel Medical Center and Rappaport Faculty of Medicine, Technion Institute of Technology, Haifa, Israel
J Pathol 198:77-82. 2002..In conclusion, the vast majority of EPTs examined expressed NP-2, suggesting its utility as a diagnostic marker for these tumours. The function of NP-2 in islet cell biology or tumourigenesis remains to be elucidated... - Segregation of arterial and venous markers in subpopulations of blood islands before vessel formationYael Herzog
Department of Cell Biology and Anatomy, and the Rappaport Family Institute for Research in the Medical Sciences, Bruce Rappaport Faculty of Medicine, Technion, Israel Institute of Technology, Haifa, 31096, Israel
Dev Dyn 232:1047-55. 2005..Of interest, even though s3f binds to np1 in vitro, np1-expressing arteries fail to bind s3f in whole-mount binding experiments... - Semaphorin-3D and semaphorin-3E inhibit the development of tumors from glioblastoma cells implanted in the cortex of the brainAdi D Sabag
Cancer Research and Vascular Biology Center, The Bruce Rappaport Faculty of Medicine, Technion, Israel Institute of Technology, Haifa, Israel
PLoS ONE 7:e42912. 2012..These results indicate that class-3 semaphorins such as sema3D and sema3E could perhaps be used to treat glioblastoma patients... - A novel asymmetric 3D in-vitro assay for the study of tumor cell invasionVera Brekhman
Cancer Research and Vascular Biology Center, The Bruce Rappaport Faculty of Medicine, Technion, Israel Institute of Technology, PO Box 9679, 1 Efron St, Haifa, 31096, Israel
BMC Cancer 9:415. 2009..Due to the cost and slowness of in-vivo invasion assays, there is need for quantitative in-vitro invasion assays that mimic as closely as possible the tumor environment and in which conditions can be rigorously controlled... - Neuropilin-1-dependent regulation of EGF-receptor signalingSabrina Rizzolio
Institute for Cancer Research at Candiolo, and University of Torino Medical School, Candiolo, Italy
Cancer Res 72:5801-11. 2012..Here we show that NRP1-blocking antibodies and NRP1 silencing can counteract ligand-induced EGFR activation in cancer cells. Thus our findings unveil a novel molecular mechanism by which NRP1 can control EGFR signaling and tumor growth... - Semaphorin 3A is a marker for disease activity and a potential immunoregulator in systemic lupus erythematosusZahava Vadasz
Division of Allergy and Clinical Immunology, Bnai Zion Medical Center, Rappaport Faculty of Medicine, Technion, Haifa 31048, Israel
Arthritis Res Ther 14:R146. 2012..This study was undertaken to evaluate the role of sema3A and NP-1 in the pathogenesis of systemic lupus erythematosus (SLE) and the specific effect of sema3A on the auto-reactive properties of B cells in SLE patients... - HVEGF165 increases survival of transplanted hepatocytes within portal radicles: suggested mechanism for early cell engraftmentHagit Shani-Peretz
Liver Unit, Rambam Medical Center, The Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, 31096 Haifa, Israel
Cell Transplant 14:49-57. 2005..Later they become included in the liver parenchyma as groups of organized cells in a process stimulated by VEGF... - Lysyl oxidase-related protein-1 promotes tumor fibrosis and tumor progression in vivoGal Akiri
Department of Cell Biology and Anatomy, The Bruce Rappaport Faculty of Medicine, Technion, Israel Institute of Technology, Haifa, 31096, Israel
Cancer Res 63:1657-66. 2003..We conclude that LOR-1 promotes tumor fibrosis and tumor invasiveness simultaneously, which indicates that these two processes may be associated... - Functional interaction of VEGF-C and VEGF-D with neuropilin receptorsTerhi Karpanen
Molecular Cancer Biology Laboratory and Ludwig Institute for Cancer Research, Biomedicum Helsinki, P O B 63, FI 00014 University of Helsinki, Helsinki, Finland
FASEB J 20:1462-72. 2006..Our results show that NP2 is directly involved in an active signaling complex with the key regulators of lymphangiogenesis and thus suggest a mechanism by which NP2 functions in the development of the lymphatic vasculature... - Neuropilin-2 interacts with VEGFR-2 and VEGFR-3 and promotes human endothelial cell survival and migrationBenoit Favier
Angiogenesis and Thrombosis Department, Sanofi Synthelabo Research, 31036 Toulouse, France
Blood 108:1243-50. 2006..Thus, our data indicate that NRP2 acts as a coreceptor that enhances human endothelial cell biological responses induced by VEGF-A and VEGF-C... - Aberrant expression of neuropilin-1 and -2 in human pancreatic cancer cellsKimi Fukahi
Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of California, Irvine, California, USA
Clin Cancer Res 10:581-90. 2004..Neuropilin (Np)-1 and -2 are coreceptors for vascular endothelial growth factor (VEGF). This study was designed to assess their role in pancreatic ductal adenocarcinoma (PDAC)... - Oncogenic transformation induces tumor angiogenesis: a role for PAR1 activationYong-Jun Yin
Department of Oncology, Hebrew University-Hadassah Medical School, Jerusalem, Israel
FASEB J 17:163-74. 2003..These data support the novel notion that initiation of cell signaling either by activating PAR1 or by the activated forms of oncogenes is sufficient to induce VEGF and hence angiogenesis... - Enhancing the vascularization of three-dimensional porous alginate scaffolds by incorporating controlled release basic fibroblast growth factor microspheresAnat Perets
Department of Biomedical Engineering, Ben-Gurion University of the Negev, Beer Sheva, Israel
J Biomed Mater Res A 65:489-97. 2003..The control over bFGF delivery and localizing its effects to areas of need, may aid in the wider application of bFGF in therapeutic angiogenesis as well as in tissue engineering... - Neuropilin-1-VEGFR-2 complexing requires the PDZ-binding domain of neuropilin-1Claudia Prahst
Joint Research Division Vascular Biology of the Medical Faculty Mannheim CBTM, University of Heidelberg
J Biol Chem 283:25110-4. 2008..Taken together, the experiments have identified a novel mechanism of NP-1 interaction with VEGFR-2, which involves the cytoplasmic domain of NP-1...