Gera Neufeld

Summary

Affiliation: Technion-Israel Institute of Technology
Country: Israel

Publications

  1. pmc Semaphorins in angiogenesis and tumor progression
    Gera Neufeld
    Cancer and Vascular Biology Research Center, Rappaport Research Institute in the Medical Sciences, Bruce Rappaport Faculty of Medicine, Technion, Israel Institute of Technology, Haifa 31096, Israel
    Cold Spring Harb Perspect Med 2:a006718. 2012
  2. ncbi request reprint Vascular endothelial growth factor (VEGF) and its receptors
    G Neufeld
    Department of Biology, Technion, Israel Institute of Technology, Technion City, Haifa 32000, Israel
    FASEB J 13:9-22. 1999
  3. doi request reprint The semaphorins: versatile regulators of tumour progression and tumour angiogenesis
    Gera Neufeld
    Cancer Research and Vascular Biology Center, The Bruce Rappaport Faculty of Medicine, Technion, Israel Institute of Technology, P O Box 9679, 1 Efron Street, Haifa, 31096, Israel
    Nat Rev Cancer 8:632-45. 2008
  4. ncbi request reprint Semaphorin signaling in vascular and tumor biology
    Gera Neufeld
    Cancer and Vascular Biology Research Center, Rappaport Research Institute in the Medical Sciences, The Bruce Rappaport Faculty of Medicine, Technion, Israel Institute of Technology, 1 Efron St, P O Box 9679, Haifa, 31096, Israel
    Adv Exp Med Biol 600:118-31. 2007
  5. ncbi request reprint Pro-angiogenic cytokines and their role in tumor angiogenesis
    Gera Neufeld
    Cancer and Vascular Biology Research Center, Rappaport Research Institute in the Medical Sciences, The Bruce Rappaport Faculty of Medicine, Technion, Israel Institute of Technology, 1 Efron St, P O Box 9679, Haifa 31096, Israel
    Cancer Metastasis Rev 25:373-85. 2006
  6. ncbi request reprint The interaction of Neuropilin-1 and Neuropilin-2 with tyrosine-kinase receptors for VEGF
    Gera Neufeld
    Department of Biology, Technion, Israel Institute of Technology, Haifa, 32000, Israel
    Adv Exp Med Biol 515:81-90. 2002
  7. ncbi request reprint Semaphorin-3A and semaphorin-3F work together to repel endothelial cells and to inhibit their survival by induction of apoptosis
    Noga Guttmann-Raviv
    Cancer and Vascular Biology Research Center, Rappaport Research Institute in the Medical Sciences, The Bruce Rappaport Faculty of Medicine, Technion, Israel Institute of Technology, Haifa 31096, Israel
    J Biol Chem 282:26294-305. 2007
  8. pmc Successful inhibition of tumor development by specific class-3 semaphorins is associated with expression of appropriate semaphorin receptors by tumor cells
    Boaz Kigel
    Cancer Research and Vascular Biology Center, The Bruce Rappaport Faculty of Medicine, Technion, Israel Institute of Technology, Haifa, Israel
    PLoS ONE 3:e3287. 2008
  9. ncbi request reprint Semaphorin-3F is an inhibitor of tumor angiogenesis
    Ofra Kessler
    Department of Cell Biology and Anatomy, Rappaport Family Institute for Research in the Medical Sciences, The Bruce Rappaport Faculty of Medicine, Technion, Israel Institute of Technology, Haifa, Israel
    Cancer Res 64:1008-15. 2004
  10. ncbi request reprint Semaphorins in cancer
    Gera Neufeld
    Cancer and Vascular Biology Research Center, Rappaport Research Institute in the Medical Sciences, The Bruce Rappaport Faculty of Medicine, Technion, Israel Institute of Technology, Haifa, Israel
    Front Biosci 10:751-60. 2005

Collaborators

  • Vera Brekhman
  • Marcelle Machluf
  • Zahava Vadasz
  • Elias Toubi
  • Guido Serini
  • Luca Tamagnone
  • Aharon Kessel
  • Hagit Dafni
  • Joel K Greenson
  • Jens Kroll
  • M Neeman
  • M Korc
  • Caroline A Heckman
  • Kari Alitalo
  • M Simons
  • H G Augustin
  • Herbert M Kagan
  • Ofra Kessler
  • Boaz Kigel
  • Niva Shraga-Heled
  • Noga Guttmann-Raviv
  • Asya Varshavsky
  • Yael Herzog
  • Tali Lange
  • Claudia Prahst
  • Jennie Lugassy
  • Adi D Sabag
  • Sabrina Rizzolio
  • Gal Akiri
  • Noa Rabinowicz
  • Tzafra Cohen
  • Benoit Favier
  • Terhi Karpanen
  • Hagit Shani-Peretz
  • Kimi Fukahi
  • Yaacov Baruch
  • Edmond Sabo
  • Limor Baruch
  • Yong Jun Yin
  • Anat Perets
  • Julia Bode
  • Victoria Smith
  • Sharon Soueid
  • Letizia Lanzetti
  • Amit Mordoviz
  • Jim Norman
  • Shelly Zaffryar-Eilot
  • Elena Rainero
  • Dorit Fink
  • Wilfried Kugler
  • Anthony A Lanahan
  • Noa Uziel
  • Shelly Zaffryar
  • Melanie Heroult
  • Sivan Abramovitch
  • Cinthya Guimaraes-Sternberg
  • Jean Pascal Herault
  • Pierre Savi
  • Jean Marc Herbert
  • Marie Mandron
  • Patricia Laboudie
  • Pauline Barron
  • Francoise Bono
  • Antoine Alam
  • Salla Keskitalo
  • Michael Jeltsch
  • Hanna Ollila
  • Pierre Fons
  • Jacques Bonnin
  • Vladislav Tsiperson
  • Ella Veitzman
  • Gideon Shoshani
  • Jun Itakura
  • Noga Gutmann-Raviv
  • Mitsuharu Fukasawa
  • Myriam Maoz
  • Noga Gan
  • Sharona Cohen Even Ram
  • Yelena Kartvelishvily
  • Zaidoun Salah
  • Smadar Cohen
  • Shalom Ochayon
  • Rachel Bar-Shavit
  • Murray Resnick
  • Shulamit Katzav
  • Felix Weisbuch
  • Gideon Shoshany
  • Asia Brodzky
  • Zoya Gluzman-Poltorak
  • Samuel Eldar

Detail Information

Publications33

  1. pmc Semaphorins in angiogenesis and tumor progression
    Gera Neufeld
    Cancer and Vascular Biology Research Center, Rappaport Research Institute in the Medical Sciences, Bruce Rappaport Faculty of Medicine, Technion, Israel Institute of Technology, Haifa 31096, Israel
    Cold Spring Harb Perspect Med 2:a006718. 2012
    ..Furthermore, loss of endogenous inhibitory semaphorin expression or function on one hand, and overexpression of protumorigenic semaphorins on the other hand, is associated with the progression of some tumor types...
  2. ncbi request reprint Vascular endothelial growth factor (VEGF) and its receptors
    G Neufeld
    Department of Biology, Technion, Israel Institute of Technology, Technion City, Haifa 32000, Israel
    FASEB J 13:9-22. 1999
    ....
  3. doi request reprint The semaphorins: versatile regulators of tumour progression and tumour angiogenesis
    Gera Neufeld
    Cancer Research and Vascular Biology Center, The Bruce Rappaport Faculty of Medicine, Technion, Israel Institute of Technology, P O Box 9679, 1 Efron Street, Haifa, 31096, Israel
    Nat Rev Cancer 8:632-45. 2008
    ..This Review focuses on the emerging role of the semaphorins in cancer...
  4. ncbi request reprint Semaphorin signaling in vascular and tumor biology
    Gera Neufeld
    Cancer and Vascular Biology Research Center, Rappaport Research Institute in the Medical Sciences, The Bruce Rappaport Faculty of Medicine, Technion, Israel Institute of Technology, 1 Efron St, P O Box 9679, Haifa, 31096, Israel
    Adv Exp Med Biol 600:118-31. 2007
    ..In this chapter we cover recent developments in this rapidly developing field of research...
  5. ncbi request reprint Pro-angiogenic cytokines and their role in tumor angiogenesis
    Gera Neufeld
    Cancer and Vascular Biology Research Center, Rappaport Research Institute in the Medical Sciences, The Bruce Rappaport Faculty of Medicine, Technion, Israel Institute of Technology, 1 Efron St, P O Box 9679, Haifa 31096, Israel
    Cancer Metastasis Rev 25:373-85. 2006
    ..Indeed, the first FDA approved anti-angiogenic drug for the treatment of cancer is Avastin, a neutralizing antibody directed against VEGF. This review focuses on cytokines which have been reported to induce tumor angiogenesis...
  6. ncbi request reprint The interaction of Neuropilin-1 and Neuropilin-2 with tyrosine-kinase receptors for VEGF
    Gera Neufeld
    Department of Biology, Technion, Israel Institute of Technology, Haifa, 32000, Israel
    Adv Exp Med Biol 515:81-90. 2002
    ..In contrast, it was recently reported by two laboratories that Neuropilins can form complexes with the second tyrosine-kinase receptor of VEGF, VEGFR1. However, the biological function of these complexes is still unclear...
  7. ncbi request reprint Semaphorin-3A and semaphorin-3F work together to repel endothelial cells and to inhibit their survival by induction of apoptosis
    Noga Guttmann-Raviv
    Cancer and Vascular Biology Research Center, Rappaport Research Institute in the Medical Sciences, The Bruce Rappaport Faculty of Medicine, Technion, Israel Institute of Technology, Haifa 31096, Israel
    J Biol Chem 282:26294-305. 2007
    ..These observations suggest that combinations of sema3A and sema3F may be able to inhibit tumor angiogenesis more effectively than single semaphorins...
  8. pmc Successful inhibition of tumor development by specific class-3 semaphorins is associated with expression of appropriate semaphorin receptors by tumor cells
    Boaz Kigel
    Cancer Research and Vascular Biology Center, The Bruce Rappaport Faculty of Medicine, Technion, Israel Institute of Technology, Haifa, Israel
    PLoS ONE 3:e3287. 2008
    ..Our results suggest that combinations of different class-3 semaphorins may be more effective than single semaphorins in cases in which tumor cells express more than one type of semaphorin receptors...
  9. ncbi request reprint Semaphorin-3F is an inhibitor of tumor angiogenesis
    Ofra Kessler
    Department of Cell Biology and Anatomy, Rappaport Family Institute for Research in the Medical Sciences, The Bruce Rappaport Faculty of Medicine, Technion, Israel Institute of Technology, Haifa, Israel
    Cancer Res 64:1008-15. 2004
    ..The tumors that did develop from s3f-expressing HEK293 cells developed at a much slower rate and had a significantly lower concentration of tumor-associated blood vessels, indicating that s3f is an inhibitor of tumor angiogenesis...
  10. ncbi request reprint Semaphorins in cancer
    Gera Neufeld
    Cancer and Vascular Biology Research Center, Rappaport Research Institute in the Medical Sciences, The Bruce Rappaport Faculty of Medicine, Technion, Israel Institute of Technology, Haifa, Israel
    Front Biosci 10:751-60. 2005
    ..In this review we discuss the semaphorins, their receptors and their signal transduction mechanisms, and evidence linking semaphorins to the control of tumorigenesis and tumor progression...
  11. ncbi request reprint Abnormal deposition of collagen around hepatocytes in Wilson's disease is associated with hepatocyte specific expression of lysyl oxidase and lysyl oxidase like protein-2
    Zehava Vadasz
    The Bruce Rappaport Faculty of Medicine, Cancer and Vascular Biology Research Center, Rappaport Family Institute for Research in the Medical Sciences, Technion, Israel Institute of Technology, P O Box 9697, 1 Efron St, 31096 Haifa, Israel
    J Hepatol 43:499-507. 2005
    ..Lysyl-oxidases catalyze the oxidation of lysine residues in collagen and elastin thereby promoting their polymerization. We have studied here the expression of four lysyl-oxidases in normal and diseased human liver...
  12. ncbi request reprint The neuropilins and their role in tumorigenesis and tumor progression
    Noga Guttmann-Raviv
    Cancer and Vascular Biology Research Center, Rappaport Research Institute in the Medical Sciences, The Bruce Rappaport Faculty of Medicine, Technion, Israel Institute of Technology, 1 Efron St, P O Box 9679, Haifa 31096, Israel
    Cancer Lett 231:1-11. 2006
    ....
  13. doi request reprint Plexin-A4 promotes tumor progression and tumor angiogenesis by enhancement of VEGF and bFGF signaling
    Boaz Kigel
    Cancer and Vascular Biology Research Center, Rappaport Research Institute in the Medical Sciences, The Bruce Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    Blood 118:4285-96. 2011
    ..Our results suggest that plexin-A4 may represent a target for the development of novel anti-angiogenic and anti-tumorigenic drugs...
  14. ncbi request reprint The neuropilins: multifunctional semaphorin and VEGF receptors that modulate axon guidance and angiogenesis
    Gera Neufeld
    Department of Biology, Technion, Israel Institute of Technology, Haifa, Israel
    Trends Cardiovasc Med 12:13-9. 2002
    ..This review focuses on the neuropilins, their interactions, and their biological roles in the nervous and cardiovascular systems...
  15. doi request reprint Receptor activity modifying protein-3 mediates the protumorigenic activity of lysyl oxidase-like protein-2
    Vera Brekhman
    Cancer Research and Vascular Biology Center, The Bruce Rappaport Faculty of Medicine, Technion, Israel Institute of Technology, Haifa, 31096, Israel
    FASEB J 25:55-65. 2011
    ..Our experiments suggest that the protumorigenic effects of LOXL2 are partially mediated by RAMP3 and that RAMP3 inhibitors may function as antitumorigenic agents. -..
  16. pmc The enzymatic activity of lysyl oxidas-like-2 (LOXL2) is not required for LOXL2-induced inhibition of keratinocyte differentiation
    Jennie Lugassy
    Cancer and Vascular Biology Research Center, Bruce Rappaport Faculty of Medicine, Technion, Israel Institute of Technology, Haifa 31096, Israel
    J Biol Chem 287:3541-9. 2012
    ..Our results suggest that agents that inhibit the enzymatic activity of LOXL2 may not suffice to inhibit completely the effects of LOXL2 on complex processes that involve altered states of cellular differentiation...
  17. ncbi request reprint VEGF162, a new heparin-binding vascular endothelial growth factor splice form that is expressed in transformed human cells
    Tali Lange
    Department of Cell Biology and Anatomy, The Bruce Rappaport Faculty of Medicine, Technion, Israel Institute of Technology, PO Box 9697, 1 Efron Street, Haifa 31096, Israel
    J Biol Chem 278:17164-9. 2003
    ....
  18. ncbi request reprint Neuropilin-1 and neuropilin-2 enhance VEGF121 stimulated signal transduction by the VEGFR-2 receptor
    Niva Shraga-Heled
    Cancer and Vascular Biology Research Center, Rappaport Research Institute in the Medical Sciences, Bruce Rappoport Faculty of Medicine, Technion, Israel Institute of Technology, Haifa 31096, Israel
    FASEB J 21:915-26. 2007
    ....
  19. ncbi request reprint Neuropilin-2 is a novel marker expressed in pancreatic islet cells and endocrine pancreatic tumours
    Tzafra Cohen
    Department of Pathology, Carmel Medical Center and Rappaport Faculty of Medicine, Technion Institute of Technology, Haifa, Israel
    J Pathol 198:77-82. 2002
    ..In conclusion, the vast majority of EPTs examined expressed NP-2, suggesting its utility as a diagnostic marker for these tumours. The function of NP-2 in islet cell biology or tumourigenesis remains to be elucidated...
  20. doi request reprint Semaphorin-3B is an angiogenesis inhibitor that is inactivated by furin-like pro-protein convertases
    Asya Varshavsky
    Cancer and Vascular Biology Research Center, Rappaport Research Institute in the Medical Sciences, The Bruce Rappaport Faculty of Medicine, Technion, Israel Institute of Technology, Haifa, Israel
    Cancer Res 68:6922-31. 2008
    ..These results suggest that up-regulation of furin-like pro-protein convertases in malignant cells may enable tumors to evade the antiangiogenic effects of sema3B...
  21. pmc Semaphorin-3D and semaphorin-3E inhibit the development of tumors from glioblastoma cells implanted in the cortex of the brain
    Adi D Sabag
    Cancer Research and Vascular Biology Center, The Bruce Rappaport Faculty of Medicine, Technion, Israel Institute of Technology, Haifa, Israel
    PLoS ONE 7:e42912. 2012
    ..These results indicate that class-3 semaphorins such as sema3D and sema3E could perhaps be used to treat glioblastoma patients...
  22. ncbi request reprint Segregation of arterial and venous markers in subpopulations of blood islands before vessel formation
    Yael Herzog
    Department of Cell Biology and Anatomy, and the Rappaport Family Institute for Research in the Medical Sciences, Bruce Rappaport Faculty of Medicine, Technion, Israel Institute of Technology, Haifa, 31096, Israel
    Dev Dyn 232:1047-55. 2005
    ..Of interest, even though s3f binds to np1 in vitro, np1-expressing arteries fail to bind s3f in whole-mount binding experiments...
  23. pmc Semaphorin 3A is a marker for disease activity and a potential immunoregulator in systemic lupus erythematosus
    Zahava Vadasz
    Division of Allergy and Clinical Immunology, Bnai Zion Medical Center, Rappaport Faculty of Medicine, Technion, Haifa 31048, Israel
    Arthritis Res Ther 14:R146. 2012
    ..This study was undertaken to evaluate the role of sema3A and NP-1 in the pathogenesis of systemic lupus erythematosus (SLE) and the specific effect of sema3A on the auto-reactive properties of B cells in SLE patients...
  24. ncbi request reprint Lysyl oxidase-related protein-1 promotes tumor fibrosis and tumor progression in vivo
    Gal Akiri
    Department of Cell Biology and Anatomy, The Bruce Rappaport Faculty of Medicine, Technion, Israel Institute of Technology, Haifa, 31096, Israel
    Cancer Res 63:1657-66. 2003
    ..We conclude that LOR-1 promotes tumor fibrosis and tumor invasiveness simultaneously, which indicates that these two processes may be associated...
  25. pmc A novel asymmetric 3D in-vitro assay for the study of tumor cell invasion
    Vera Brekhman
    Cancer Research and Vascular Biology Center, The Bruce Rappaport Faculty of Medicine, Technion, Israel Institute of Technology, PO Box 9679, 1 Efron St, Haifa, 31096, Israel
    BMC Cancer 9:415. 2009
    ..Due to the cost and slowness of in-vivo invasion assays, there is need for quantitative in-vitro invasion assays that mimic as closely as possible the tumor environment and in which conditions can be rigorously controlled...
  26. doi request reprint Neuropilin-1-dependent regulation of EGF-receptor signaling
    Sabrina Rizzolio
    Institute for Cancer Research at Candiolo, and University of Torino Medical School, Candiolo, Italy
    Cancer Res 72:5801-11. 2012
    ..Here we show that NRP1-blocking antibodies and NRP1 silencing can counteract ligand-induced EGFR activation in cancer cells. Thus our findings unveil a novel molecular mechanism by which NRP1 can control EGFR signaling and tumor growth...
  27. ncbi request reprint HVEGF165 increases survival of transplanted hepatocytes within portal radicles: suggested mechanism for early cell engraftment
    Hagit Shani-Peretz
    Liver Unit, Rambam Medical Center, The Bruce Rappaport Faculty of Medicine, Technion Israel Institute of Technology, 31096 Haifa, Israel
    Cell Transplant 14:49-57. 2005
    ..Later they become included in the liver parenchyma as groups of organized cells in a process stimulated by VEGF...
  28. ncbi request reprint Neuropilin-2 interacts with VEGFR-2 and VEGFR-3 and promotes human endothelial cell survival and migration
    Benoit Favier
    Angiogenesis and Thrombosis Department, Sanofi Synthelabo Research, 31036 Toulouse, France
    Blood 108:1243-50. 2006
    ..Thus, our data indicate that NRP2 acts as a coreceptor that enhances human endothelial cell biological responses induced by VEGF-A and VEGF-C...
  29. ncbi request reprint Aberrant expression of neuropilin-1 and -2 in human pancreatic cancer cells
    Kimi Fukahi
    Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of California, Irvine, California, USA
    Clin Cancer Res 10:581-90. 2004
    ..Neuropilin (Np)-1 and -2 are coreceptors for vascular endothelial growth factor (VEGF). This study was designed to assess their role in pancreatic ductal adenocarcinoma (PDAC)...
  30. ncbi request reprint Oncogenic transformation induces tumor angiogenesis: a role for PAR1 activation
    Yong Jun Yin
    Department of Oncology, Hebrew University Hadassah Medical School, Jerusalem, Israel
    FASEB J 17:163-74. 2003
    ..These data support the novel notion that initiation of cell signaling either by activating PAR1 or by the activated forms of oncogenes is sufficient to induce VEGF and hence angiogenesis...
  31. ncbi request reprint Functional interaction of VEGF-C and VEGF-D with neuropilin receptors
    Terhi Karpanen
    Molecular Cancer Biology Laboratory and Ludwig Institute for Cancer Research, Biomedicum Helsinki, P O B 63, FI 00014 University of Helsinki, Helsinki, Finland
    FASEB J 20:1462-72. 2006
    ..Our results show that NP2 is directly involved in an active signaling complex with the key regulators of lymphangiogenesis and thus suggest a mechanism by which NP2 functions in the development of the lymphatic vasculature...
  32. pmc Neuropilin-1-VEGFR-2 complexing requires the PDZ-binding domain of neuropilin-1
    Claudia Prahst
    Joint Research Division Vascular Biology of the Medical Faculty Mannheim CBTM, University of Heidelberg
    J Biol Chem 283:25110-4. 2008
    ..Taken together, the experiments have identified a novel mechanism of NP-1 interaction with VEGFR-2, which involves the cytoplasmic domain of NP-1...
  33. ncbi request reprint Enhancing the vascularization of three-dimensional porous alginate scaffolds by incorporating controlled release basic fibroblast growth factor microspheres
    Anat Perets
    Department of Biomedical Engineering, Ben Gurion University of the Negev, Beer Sheva, Israel
    J Biomed Mater Res A 65:489-97. 2003
    ..The control over bFGF delivery and localizing its effects to areas of need, may aid in the wider application of bFGF in therapeutic angiogenesis as well as in tissue engineering...