R Nagler

Summary

Affiliation: Technion-Israel Institute of Technology
Country: Israel

Publications

  1. pmc Pleural fluid analysis of lung cancer vs benign inflammatory disease patients
    R Kremer
    Department of General Thoracic Surgery, Rambam Health Care Campus, Haifa, Israel
    Br J Cancer 102:1180-4. 2010
  2. pmc Saliva--a pivotal player in the pathogenesis of oropharyngeal cancer
    A Z Reznick
    Department of Oral and Maxillofacial Surgery, Oral Biochemistry Laboratory and Salivary Clinic, Rambam Medical Center and Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    Br J Cancer 91:111-8. 2004
  3. pmc Salivary analysis of oral cancer biomarkers
    T Shpitzer
    Department of Otorhinolaryngology, Rabin Medical Center, Petah Tiqva and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    Br J Cancer 101:1194-8. 2009
  4. ncbi request reprint Oral cancer induced by cigarette smoke--the mediatory role of the salivary antioxidant system
    Rafael M Nagler
    Department of Oral and Maxillofacial Surgery, Oral Biochemistry Laboratory and Salivary Clinic, Rambam Medical Center, Bruce Rappaport Faculty of Medicine, Technion Israel Institute of Technology, P O B 9649, 31096 Haifa, Israel
    Anticancer Res 23:5125-8. 2003
  5. ncbi request reprint Sialochemical and gustatory analysis in patients with oral sensory complaints
    Rafael M Nagler
    Department of Oral and Maxillofacial Surtery, Oral Biochemistry Laboratory and Salivary Clinic, Rambam Medical Center, Haifa, Israel
    J Pain 5:56-63. 2004
  6. ncbi request reprint Salivary gland involvement in graft-versus-host disease: the underlying mechanism and implicated treatment
    Raphael M Nagler
    Department of Oral and Maxillofacial Surgery, Oral Biochemistry Laboratory and Salivary Clinic, Rambam Medical Center, Affiliated to Technion Faculty of Medicine, Haifa, Israel
    Isr Med Assoc J 6:167-72. 2004
  7. ncbi request reprint The molecular basis of salivary gland involvement in graft--vs.--host disease
    R M Nagler
    Department of Oral and Maxillofacial Surgery, Oral Biochemistry Laboratory and Salivary Clinic, Rambam Medical Center, and Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    J Dent Res 83:98-103. 2004
  8. ncbi request reprint Salivary glands and the aging process: mechanistic aspects, health-status and medicinal-efficacy monitoring
    R M Nagler
    Department of Oral and Maxillofacial Surgery, Oral Biochemistry Laboratory and Salivary Clinic, Rambam Medical Center, Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    Biogerontology 5:223-33. 2004
  9. ncbi request reprint Cigarette smoke effects on salivary antioxidants and oral cancer--novel concepts
    Rafael M Nagler
    Department of Oral and Maxillofacial Surgery and Oral Biochemistry Laboratory, Rambam Medical Center, Haifa, Israel
    Isr Med Assoc J 6:691-4. 2004
  10. ncbi request reprint Relationships between age, drugs, oral sensorial complaints and salivary profile
    Rafael M Nagler
    Department of Oral and Maxillofacial Surgery, Oral Biochemistry Laboratory and Salivary Clinic, Rambam Medical Centre and Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    Arch Oral Biol 50:7-16. 2005

Collaborators

Detail Information

Publications71

  1. pmc Pleural fluid analysis of lung cancer vs benign inflammatory disease patients
    R Kremer
    Department of General Thoracic Surgery, Rambam Health Care Campus, Haifa, Israel
    Br J Cancer 102:1180-4. 2010
    ..Correct diagnosis of pleural effusion (PE) as either benign or malignant is crucial, although conventional cytological evaluation is of limited diagnostic accuracy, with relatively low sensitivity rates...
  2. pmc Saliva--a pivotal player in the pathogenesis of oropharyngeal cancer
    A Z Reznick
    Department of Oral and Maxillofacial Surgery, Oral Biochemistry Laboratory and Salivary Clinic, Rambam Medical Center and Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    Br J Cancer 91:111-8. 2004
    ....
  3. pmc Salivary analysis of oral cancer biomarkers
    T Shpitzer
    Department of Otorhinolaryngology, Rabin Medical Center, Petah Tiqva and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    Br J Cancer 101:1194-8. 2009
    ..Oral cancer is a common and lethal malignancy. Direct contact between saliva and the oral cancer lesion makes measurement of tumour markers in saliva an attractive alternative to serum testing...
  4. ncbi request reprint Oral cancer induced by cigarette smoke--the mediatory role of the salivary antioxidant system
    Rafael M Nagler
    Department of Oral and Maxillofacial Surgery, Oral Biochemistry Laboratory and Salivary Clinic, Rambam Medical Center, Bruce Rappaport Faculty of Medicine, Technion Israel Institute of Technology, P O B 9649, 31096 Haifa, Israel
    Anticancer Res 23:5125-8. 2003
  5. ncbi request reprint Sialochemical and gustatory analysis in patients with oral sensory complaints
    Rafael M Nagler
    Department of Oral and Maxillofacial Surtery, Oral Biochemistry Laboratory and Salivary Clinic, Rambam Medical Center, Haifa, Israel
    J Pain 5:56-63. 2004
    ..This report might add an important objective diagnostic tool to the clinician treating such patients...
  6. ncbi request reprint Salivary gland involvement in graft-versus-host disease: the underlying mechanism and implicated treatment
    Raphael M Nagler
    Department of Oral and Maxillofacial Surgery, Oral Biochemistry Laboratory and Salivary Clinic, Rambam Medical Center, Affiliated to Technion Faculty of Medicine, Haifa, Israel
    Isr Med Assoc J 6:167-72. 2004
    ..The present review describes the GVHD-related sialometric and sialochemical data available in the literature for both major and minor salivary glands in both human and rodent models, and discusses a possible mechanism...
  7. ncbi request reprint The molecular basis of salivary gland involvement in graft--vs.--host disease
    R M Nagler
    Department of Oral and Maxillofacial Surgery, Oral Biochemistry Laboratory and Salivary Clinic, Rambam Medical Center, and Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    J Dent Res 83:98-103. 2004
    ....
  8. ncbi request reprint Salivary glands and the aging process: mechanistic aspects, health-status and medicinal-efficacy monitoring
    R M Nagler
    Department of Oral and Maxillofacial Surgery, Oral Biochemistry Laboratory and Salivary Clinic, Rambam Medical Center, Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    Biogerontology 5:223-33. 2004
    ..The current review focuses on age-related histological, sialometrical and sialochemical changes and on the possible mechanisms which underlie these changes. Finally, directions for further exploring the subject are suggested...
  9. ncbi request reprint Cigarette smoke effects on salivary antioxidants and oral cancer--novel concepts
    Rafael M Nagler
    Department of Oral and Maxillofacial Surgery and Oral Biochemistry Laboratory, Rambam Medical Center, Haifa, Israel
    Isr Med Assoc J 6:691-4. 2004
  10. ncbi request reprint Relationships between age, drugs, oral sensorial complaints and salivary profile
    Rafael M Nagler
    Department of Oral and Maxillofacial Surgery, Oral Biochemistry Laboratory and Salivary Clinic, Rambam Medical Centre and Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    Arch Oral Biol 50:7-16. 2005
    ....
  11. ncbi request reprint Age-related changes in unstimulated salivary function and composition and its relations to medications and oral sensorial complaints
    Rafael M Nagler
    Department of Oral and Maxillofacial Surgery, Oral Biochemistry Laboratory and Salivary Clinic, Rambam Medical Center and Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    Aging Clin Exp Res 17:358-66. 2005
    ..OSC cover xerostomia, disturbed sense of taste, or burning mouth sensitivity with no established classical etiology (e.g., Sjogren's syndrome, or a response to radiotherapy)...
  12. ncbi request reprint Salivary antioxidant capacity in graft versus host disease
    Rafael Nagler
    Oral and Maxillofacial Surgical Department, Oral Biochemistry Laboratory and Salivary Clinic, Rambam Medical Center, Faculty of Medicine, Technion Institute, Haifa, Israel
    Cancer Invest 24:269-77. 2006
    ..Therapy with artificial saliva and free radical scavengers and/or antioxidants (administered either systemically or via oral rinses) thus, may be of clinical relevance...
  13. ncbi request reprint Concomitant analysis of salivary tumor markers--a new diagnostic tool for oral cancer
    Rafael Nagler
    Department of Oral and Maxillofacial Surgical and Oral Biochemistry Laboratory, Rambam Medical Center and Rappaport Faculty of Medicine, Israel Institute of Technology Technion, Haifa, Israel
    Clin Cancer Res 12:3979-84. 2006
    ..The purpose of the current study was to examine tumor markers in the saliva of OSCC patients...
  14. doi request reprint Penicillamine as a potent protector against injurious effects of cigarette smoke in aerodigestive tract cancer
    Rafael Nagler
    Department of Molecular Pharmacology, Rappaport Family Institute for Research in the Medical Sciences, Technion Israel Institute of Technology, Haifa 31096, Israel
    Oncology 78:12-9. 2010
    ..Cigarette smoke (CS) is the major risk factor for aerodigestive tract cancers such as lung and oral cancers...
  15. doi request reprint Oral cancer, cigarette smoke and mitochondrial 18kDa translocator protein (TSPO) - In vitro, in vivo, salivary analysis
    Rafael Nagler
    Department of Oral and Maxillofacial Surgery and Laboratory of Oral Biochemistry, Rambam Medical Center and the Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa, 31096, Israel
    Biochim Biophys Acta 1802:454-61. 2010
    ..We suggest that this may be related to a predisposition for occurrence of oral cancer...
  16. doi request reprint Saliva as a tool for oral cancer diagnosis and prognosis
    Rafael M Nagler
    Department of Oral and Maxillofacial Surgery and Oral Biochemistry Laboratory, Rambam Medical Center and Rappaport Faculty of Medicine, Israel Institute of Technology Technion, Haifa 31096, Israel
    Oral Oncol 45:1006-10. 2009
    ..At this point however, the aim of salivary analysis is mainly for screening which may be helpful in the future...
  17. doi request reprint The expression and prognostic significance of Cks1 in salivary cancer
    Rafael M Nagler
    Department of Oral and Maxillofacial Surgery and Oral Biochemistry Laboratory, Rambam Medical Center and Bruce Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    Cancer Invest 27:512-20. 2009
    ..High expression of Cks1 WAS strongly associated with lymph node metastases and poor prognosis and survival. Cks1 alterations may have a significant biological role in the pathogenesis of salivary cancer...
  18. ncbi request reprint Cigarette smoke decreases salivary 18 kDa translocator protein binding affinity--in association with oxidative stress
    R Nagler
    Department of Molecular Pharmacology, Medical Faculty, Rappaport Family Institute for Research in the Medical Sciences, Technion Israel Institute of Technology, 31096 Haifa, Israel
    Curr Med Chem 17:2539-46. 2010
    ..Thus, our study shows that TSPO is present in the cellular component of saliva. Interestingly, in vitro this cellular TSPO is affected by exposure of the whole saliva to cigarette smoke, in negative correlation with oxidative stress...
  19. doi request reprint Induced acute hereditary angioedema: a life-threatening condition
    Rafael Nagler
    Department of Oral and Maxillofacial Surgery, Baruch Padeh Medical Center Poriya, Tiberias, Israel
    J Oral Maxillofac Surg 66:1287-9. 2008
  20. ncbi request reprint Altered salivary profile in heavy smokers and its possible connection to oral cancer
    R M Nagler
    Department of Oral and Maxillofacial Surgery and Oral Biochemistry Laboratory, Rambam Medical Center and Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    Int J Biol Markers 22:274-80. 2007
    ..Hence, further research aimed at examining the possibility of administration of agents as antioxidants or saliva substitutes to the oral cavity of smokers should be considered...
  21. ncbi request reprint Heparanase up-regulation in tongue cancer: tissue and saliva analysis
    Rafael Nagler
    Department of Oral and Maxillofacial Surgery and Oral Biochemistry Laboratory, Rambam Medical Center and Bruce Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    Cancer 110:2732-9. 2007
    ..Heparanase up-regulation has been correlated with reduced postoperative survival in various cancers...
  22. ncbi request reprint The dual role of saliva in oral carcinogenesis
    Rafael Nagler
    Oral and Maxillofacial Surgery Department, Biochemistry Laboratory and Salivary Clinic, Rambam Medical Center and Bruce Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    Oncology 71:10-7. 2006
    ..This is a novel concept recognizing that when exposed to CS, salivary behavior is reversed and saliva loses its antioxidant capacity, becoming a potent pro-oxidant milieu...
  23. ncbi request reprint Effects of head and neck radiotherapy on major salivary glands--animal studies and human implications
    R M Nagler
    Department of Oral and Maxillofacial Surgery, Oral Biochemistry Laboratory and Salivary Clinic, Rambam Medical Center, Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    In Vivo 17:369-75. 2003
    ..The purpose of this review is to suggest an updated description of early and late irradiation effects on salivary glands in rodents. Based on this description, the mechanism of the underlying xerostomia will be discussed...
  24. ncbi request reprint Salivary gland involvement in rheumatoid arthritis and its relationship to induced oxidative stress
    R M Nagler
    Department of Oral and Maxillofacial Surgery, Rambam Medical Center and the Bruce Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa
    Rheumatology (Oxford) 42:1234-41. 2003
    ..The objective of the present study was to analyse salivary gland and free radical involvement in rheumatoid arthritis (RA)...
  25. ncbi request reprint Prognostic role of apoptotic, Bcl-2, c-erbB-2 and p53 tumor markers in salivary gland malignancies
    Rafael M Nagler
    Department of Pathology, Rambam Medical Center and Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    Oncology 64:389-98. 2003
    ....
  26. ncbi request reprint The effect of pilocarpine on salivary constituents in patients with chronic graft-versus-host disease
    R M Nagler
    Bone Marrow Transplantation Department and Cancer Biology Research Laboratory, Hadassah University Hospital, Jerusalem, Israel
    Arch Oral Biol 46:689-95. 2001
    ..As the biochemical and immunological composition of saliva provides its protective antimicrobial characteristics, the ability of pilocarpine to abrogate cGVHD salivary gland abnormalities may be of clinical significance...
  27. ncbi request reprint The effect of low-dose interleukin-2-based immunotherapy on salivary function and composition in patients with metastatic renal cell carcinoma
    R M Nagler
    Oral Biochemistry Laboratory, Rambam Medical Center and Technion Israel Institute of Technology, Haifa, Israel
    Arch Oral Biol 46:487-93. 2001
    ..We recommend salivary-supporting therapies and anticariogenic treatments for patients undergoing low-dose rIL-2-based immunotherapy...
  28. ncbi request reprint Short-term systemic effects of head and neck irradiation
    R M Nagler
    Department of Oral and Maxillofacial Surgery, Rambam Medical Center, Haifa, Israel
    Anticancer Res 20:1865-70. 2000
    ..The potential modulatory role of zinc-desferrioxamine [Zn-DFO] on IR effects was examined because of its known ability to protect against the damage induced by free radicals which are mediated by redox-active metal ions...
  29. ncbi request reprint The enigmatic mechanism of irradiation-induced damage to the major salivary glands
    R M Nagler
    Department of Oral and Maxillofacial Surgery, Rambam Medical Center, Faculty of Medicine, Technion Israel Institute of Technology, Haifa
    Oral Dis 8:141-6. 2002
    ..These metal ions, which seem to be associated with secretion granules, are not necessarily contained within the granules as previously suggested, but rather are probably located at sites more proximal to the DNA...
  30. ncbi request reprint Invading basal cell carcinoma of the jaw: an under-evaluated complex entity
    R M Nagler
    Department of Oral and Maxillofacial Surgery, Rambam Medical Center and Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    Anticancer Res 21:759-64. 2001
    ..Such therapy requires a combination of modalities offered by both plastic and maxillofacial surgeons, as well as oral and dental rehabilitators...
  31. ncbi request reprint Extended-term effects of head and neck irradiation in a rodent
    R M Nagler
    Department of Oral and Maxillofacial Surgery and Oral Biochemistry Laboratory, Rambam Medical Center and Faculty of Medicine, Technion, Israel Institute of Technology, Haifa, Israel
    Eur J Cancer 37:1938-45. 2001
    ..The clinical implications for head and neck patients require further evaluation, but our data should be considered, in the context of the available evidence for the long-term effects of head and neck irradiation in humans...
  32. ncbi request reprint Sarcoma of the maxillofacial region: follow-up of 25 cases
    R M Nagler
    Department of Oral and Maxillofacial Surgery, Rambam Medical Center, Haifa, Israel
    Anticancer Res 20:3735-41. 2000
    ..Approximately 10% of all cases of osteosarcoma, a subtype with a particularly poor prognosis, occur in the head and neck...
  33. ncbi request reprint Molecular aspects of oral cancer
    Rafael M Nagler
    Department of Oral and Maxillofacial Surgery, Oral Biochemistry and Salivary Clinic, Rambam Medical Center, Bruce Rappaort Faculty of Medicine, Technion Israel Institute of Technology, POB 9649, 31096 Haifa, Israel
    Anticancer Res 22:2977-80. 2002
    ..Particular attention is paid to quantitative DNA (aneuploidy) and oncogenes. The pivotal tumor suppressor gene, p53, is dealt with in depth...
  34. ncbi request reprint Sjögren's syndrome induced by estrogen therapy
    R M Nagler
    Department of Oral and Maxillofacial Surgery, Rambam Medical Center, Haifa, Israel
    Semin Arthritis Rheum 30:209-14. 2000
    ..To describe a possible role for estrogen in the induction or acceleration of Sjögren's syndrome (SS)...
  35. ncbi request reprint Multidisciplinary and multistage treatment of complex facial trauma: case report
    Rafael M Nagler
    Department of Oral and Maxillofacial Surgery, Rambam Medical Center, Haifa, Israel
    Aesthetic Plast Surg 26:40-3. 2002
    ..We present a patient with complex facial trauma, discuss his injury characteristics and the multistage treatment performed, and review the literature...
  36. ncbi request reprint Partial protection of rat parotid glands from irradiation-induced hyposalivation by manganese superoxide dismutase
    R M Nagler
    Department of Anatomy and Cell Biology, Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    Arch Oral Biol 45:741-7. 2000
    ..Both MnSOD and Cu/ZnSOD partially protect against irradiation-induced WBC loss. The parotid gland is partially protected by MnSOD but not Cu/ZnSOD, while the submandibular gland is not protected by either MnSOD or Cu/ZnSOD...
  37. ncbi request reprint Prophylactic treatment reduces the severity of xerostomia following radiation therapy for oral cavity cancer
    Rafael M Nagler
    Department of Oral and Maxillofacial Surgery, Rambam Medical Center, POB 9602, Haifa 31096, Israel
    Arch Otolaryngol Head Neck Surg 129:247-50. 2003
  38. ncbi request reprint Sialometrical and sialochemical analysis of patients with chronic graft-versus-host disease--a prolonged study
    R M Nagler
    Sheba Medical Center, Tel Hashamer, Israel
    Cancer Invest 21:34-40. 2003
    ....
  39. ncbi request reprint Selective embolization for head and neck vasculopathies
    Rafael M Nagler
    Oral and Maxillofacial Surgery Department, Rambam Medical Center, Technion Israel Institute of Technology, Haifa
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 93:127-31. 2002
    ..However, the reported experience with this therapeutic modality for head and neck lesions is rather limited...
  40. ncbi request reprint Major salivary gland involvement in graft-versus-host disease: considerations related to pathogenesis, the role of cytokines and therapy
    R M Nagler
    Department of Oral and Maxillofacial Surgery, Rambam Medical Center and Faculty of Medicine, Technion Israel Institute of Technology, Haifa
    Cytokines Cell Mol Ther 5:227-32. 1999
    ..The purpose of this review is to summarize the data that have been published recently concerning salivary involvement in GVHD and to suggest an underlying mechanism for the disease and its related 'state-of-the-art' therapeutic policy...
  41. ncbi request reprint Genioglossal advancement--a simple surgical procedure for sleep apnea. Case report and literature review
    R M Nagler
    Department of Oral and Maxillofacial Surgery, Rambam Medical Center and Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    Eur Surg Res 34:373-7. 2002
    ..We present a procedure for patients whose sleep apnea is due to extensive mandibular retrognathism with concomitant retrolingual narrowing and collapse...
  42. ncbi request reprint Saliva analysis in the clinical setting: revisiting an underused diagnostic tool
    Rafael M Nagler
    Department of Anatomy and Cell Biology, Rambam Medical Center and the Bruce Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa
    J Investig Med 50:214-25. 2002
    ..Another purpose was to concomitantly compare these and other oral/salivary parameters differentially in whole, parotid, and submandibular and sublingual saliva to examine the source of those parameters and their specific concentrations...
  43. ncbi request reprint Irradiation-induced damage to the salivary glands: the role of redox-active iron and copper
    R Nagler
    The Department of Cellular Biochemistry, The Hebrew University Hadassah School of Medicine, Jerusalem, Israel
    Radiat Res 147:468-76. 1997
    ....
  44. pmc Heparanase expression in malignant salivary gland tumors inversely correlates with long-term survival
    Ofer Ben-Izhak
    Department of Pathology, Rambam Medical Center, Bruce Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    Neoplasia 8:879-84. 2006
    ..Heparanase expression correlated with enhanced local and distant metastatic spread, increased vascular density, and reduced postoperative survival...
  45. ncbi request reprint [Oral cancer--molecular aberrations and tumor markers cellular aberrations]
    Rafael Nagler
    Oral and Maxillofacial Surgery Department, Oral Biochemistry Laboratory, Rambam Medical Center, Faculty of Medicine, Technion, Haifa, Israel
    Harefuah 142:272-6, 318, 317. 2003
    ..In any case, oral cancer remains a disfiguring disease associated with a high mortality rate...
  46. ncbi request reprint Salivary gland involvement and oxidative stress in juvenile idiopathic arthritis: novel observation in oligoarticular-type patients
    Riva Brik
    Department of Pediatrics and Pediatric Rheumatology Service, Meyer Children s Hospital of Haifa, Rambam Medical Center, Technion, Haifa, Israel
    J Rheumatol 33:2532-7. 2006
    ..We studied the salivary composition and the antioxidant profile in patients with JIA, as well as their serum antioxidant status...
  47. pmc Salivary antioxidants and metalloproteinases in juvenile idiopathic arthritis
    Riva Brik
    Meyer Children s Hospital, Haifa, Israel
    Mol Med 16:122-8. 2010
    ..Anti-TNF treatment may modulate the degradation process during the course of arthritis by inhibition of the activity of MMP...
  48. ncbi request reprint Effect of HAART on salivary composition and oxidative profile in HIV-infected patients
    Eduardo Shahar
    Institute of Allergy, Clinical Immunology and AIDS, Rambam Medical Center, Haifa, Israel
    Curr HIV Res 6:447-51. 2008
    ..Salivary collection is simple, non-invasive and not associated with risk of infection spread. Antioxidants in HIV patients may be recommended, as well as local oral means aimed at resuming salivary functions compromised in HIV patients...
  49. ncbi request reprint [Oral cancer--nuclear acid and genomic aberrations]
    R Nagler
    Oral and Maxillofacial Surgery Department, Oral Biochemistry Laboratory, Rambam Medical Center, Faculty of Medicine, Technion, Haifa, Israel
    Harefuah 142:862-6, 876. 2003
    ..In any case oral cancer remains a disfiguring disease associated with a high mortality rate. Abstinence from smoking and alcohol is the best approach to prevent its occurrence...
  50. ncbi request reprint Oxidative stress indices in COPD--Broncho-alveolar lavage and salivary analysis
    Mordechai Yigla
    Pulmunology Department, Rambam Medical Center and Bruce Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa 31096, Israel
    Arch Oral Biol 52:36-43. 2007
    ..The purpose of this study was to further evaluate this role as concomitantly expressed in the saliva and broncho-alveolar lavage (BAL/'lavage')...
  51. ncbi request reprint Oropharyngeal cancer pathogenesis: ubiquitin proteolytic, apoptotic and epidermal growth factor related pathways act in concert--first report
    Ofer Ben-Izhak
    Department of Pathology, Rambam Medical Center, Israel
    Oral Oncol 41:851-60. 2005
    ..The accumulated data may be employed in the future for a better understanding of the biology behind oral cancer and for developing better means of detection and treatment...
  52. ncbi request reprint Squamous cell carcinoma of the tongue: the prevalence and prognostic roles of p53, Bcl-2, c-erbB-2 and apoptotic rate as related to clinical and pathological characteristics in a retrospective study
    Rafael M Nagler
    Department of Oral and Maxillofacial Surgery, Rambam Medical Center and Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    Cancer Lett 186:137-50. 2002
    ..0001). The possible biological significance of these markers in tongue SCC is discussed in relation to the current literature, and an independent role for TUNEL and p53 is suggested...
  53. ncbi request reprint Lethal synergistic effect of cigarette smoke and saliva in an in vitro model: does saliva have a role in the development of oral cancer?
    Oded Hershkovich
    Department of Oral and Maxillofacial Surgery, Oral Biochemistry Laboratory, Rambam Medical Center, Technion Israel Institute of Technology, 31096 Haifa, Israel
    Eur J Cancer 40:1760-7. 2004
    ..OH(-)-free radicals. In light of these results, a comprehensive mechanism for the induction of oral cancer by cigarette smoke is suggested where saliva may be a pivotal player...
  54. ncbi request reprint Biochemical analysis of saliva and taste acuity evaluation in patients with burning mouth syndrome, xerostomia and/or gustatory disturbances
    Oded Hershkovich
    Oral Biochemistry Laboratory and Salivary Clinic, Department of Oral and Maxillofacial Surgery, Faculty of Medicine, Rambam Medical Center, Technion Israel Institute of Technology, P O B 9602, Haifa 31096, Israel
    Arch Oral Biol 49:515-22. 2004
    ..In the current study, we performed taste and salivary analysis on patients suffering from burning mouth syndrome and xerostomia or taste disturbances...
  55. ncbi request reprint Salivary analysis in oral cancer patients: DNA and protein oxidation, reactive nitrogen species, and antioxidant profile
    Gideon Bahar
    Department of Otorhinolaryngology, Rabin Medical Center, Petah Tiqva and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    Cancer 109:54-9. 2007
    ..The RNS (nitrosamines: nitrates, NO(3), and nitrites, NO(2)) are also produced by the reaction of ROS and other free radicals with nitric oxide (NO) and are therefore in equilibrium with it...
  56. ncbi request reprint Inhibition of oral peroxidase activity by cigarette smoke: in vivo and in vitro studies
    Abraham Z Reznick
    Department of Anatomy and Cell Biology, The Bruce Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    Free Radic Biol Med 34:377-84. 2003
    ..This may pave the way for the CS-induced and saliva-mediated initiation and progression of oral cancer...
  57. ncbi request reprint Synergistic effect of cigarette smoke and saliva on lymphocytes--the mediatory role of volatile aldehydes and redox active iron and the possible implications for oral cancer
    Erez Hasnis
    Department of Anatomy and Cell Biology, Rambam Medical Center and the Bruce Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    Int J Biochem Cell Biol 36:826-39. 2004
    ....
  58. ncbi request reprint Effect of cigarette smoke on oral peroxidase activity in human saliva: role of hydrogen cyanide
    Ifat Klein
    Department of Anatomy and Cell Biology, Bruce Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    Free Radic Biol Med 35:1448-52. 2003
    ..The finding of reduced salivary OPO levels after CS exposure may represent a contributory mechanism for CS-related compromises in antimicrobial defenses in the aerodigestive tract...
  59. ncbi request reprint Association between regional idiopathic neuropathy and salivary involvement as the possible mechanism for oral sensory complaints
    Michal Granot
    Faculty of Social Welfare and Health Studies, University of Haifa, Haifa, Israel
    J Pain 6:581-7. 2005
    ..Alternatively, a primary idiopathic salivary dysfunction might cause sensory neural dysfunction at the receptor level by changing the oral cavity milieu...
  60. doi request reprint Sialochemical and oxidative analyses in radioactive I131-treated patients with thyroid carcinoma
    Sophia Ish-Shalom
    Metabolic Bone Disease Unit, Rambam Medical Center, 31096 Haifa, Israel
    Eur J Endocrinol 158:677-81. 2008
    ..This study examined the effects of radioactive I131 on salivary gland activity, saliva composition and oxidative profile, and related oral discomfort complaints following thyroidectomy due to carcinoma of thyroid gland...
  61. ncbi request reprint Characterization of the differentiated antioxidant profile of human saliva
    Rafael M Nagler
    Department of Oral and Maxillofacial Surgery, Oral Biochemistry Laboratory and Salivary Clinic, Rambam Medical Center, Haifa, Israel
    Free Radic Biol Med 32:268-77. 2002
    ..This also may signify that our oral cavity environment is only partially protected against oxidative stress during most of the day and night...
  62. ncbi request reprint Age-related changes in salivary antioxidant profile: possible implications for oral cancer
    Oded Hershkovich
    Oral Biochemistry Laboratory, Rambam Medical Center and Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    J Gerontol A Biol Sci Med Sci 62:361-6. 2007
    ..Administration of local therapeutic agents (i.e., antioxidants) to the oral cavity should be considered...
  63. ncbi request reprint A comprehensive salivary analysis for oral cancer diagnosis
    Thomas Shpitzer
    Department of Otorhinolaryngology, Rabin Medical Center, Petah Tiqva and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    J Cancer Res Clin Oncol 133:613-7. 2007
    ..This study utilized comprehensive salivary analysis to evaluate biochemical and immunological parameters in the saliva of oral squamous cell carcinoma (OSCC) patients...
  64. ncbi request reprint Relationship of flow rate, uric acid, peroxidase, and superoxide dismutase activity levels with complications in diabetic patients: can saliva be used to diagnose diabetes?
    Moshe Zloczower
    Endocrine Department and Diabetes in Pregnancy Clinic, Rambam Medical Center, Haifa, Israel
    Antioxid Redox Signal 9:765-73. 2007
    ..This observation unveils the opportunity to use noninvasive saliva-based diagnostics for diabetes mellitus patients...
  65. ncbi request reprint Free radicals related effects and antioxidants in saliva and serum of adolescents with Type 1 diabetes mellitus
    Abraham Z Reznick
    Department of Anatomy and Cell Biology, Rambam Medical Center and Bruce Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    Arch Oral Biol 51:640-8. 2006
    ..The purpose of the current study was to analyze both serum and salivary composition and oxidative stress markers in Type 1 diabetes mellitus (DM) patients...
  66. ncbi request reprint Salivary oxidative stress in children during acute asthmatic attack and during remission
    Lea Bentur
    Pediatric Pulmonology Unit, Meyer Children s Hospital, Rambam Medical Center, P O Box 9602, Haifa 31092, Israel
    Respir Med 100:1195-201. 2006
    ..We undertook this study to analyze the salivary oxidative profile and composition in children with asthma during attack and remission, and to compare them with the levels of salivary antioxidants of healthy control children...
  67. doi request reprint Compositional and oxidative analysis in the saliva and serum of predialysis chronic kidney disease patients and end-stage renal failure patients on peritoneal dialysis
    Guy Bibi
    Rambam Medical Center and Bruce Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    Ther Apher Dial 12:164-70. 2008
    ..03). In contrast, salivary peroxidase and SOD were higher by 15% and 35%, respectively (P = 0.01), in these patients. We suggest monitoring salivary UA for assessing the baseline oral oxidative status of CRF and dialyzed patients...
  68. doi request reprint Salivary beta2-microglobulin analysis in chronic kidney disease and hemodialyzed patients
    Regina Michelis
    Eliachar Research Laboratory, Western Galilee Hospital, Nahariya, Israel
    Blood Purif 25:505-9. 2007
    ..Beta2-microglobulin (beta2m) is a major component in dialysis-related amyloidosis, a disabling disease affecting long-term dialysis patients...
  69. doi request reprint Saliva analysis for monitoring dialysis and renal function
    Rafael M Nagler
    Clin Chem 54:1415-7. 2008
  70. ncbi request reprint Effects of diabetes mellitus, chronic renal failure and hemodialysis on serum and salivary antioxidant status
    Ilan Ben-Zvi
    Nephrology Department, Rambam Medical Center and Bruce Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    Nephron Clin Pract 105:c114-20. 2007
    ..To analyze various oxidative stress parameters in the saliva and serum of patients with chronic renal failure (CRF) and/or diabetes mellitus (DM), and to compare them in dialytic vs. pre-dialytic patients...
  71. doi request reprint Serum and salivary oxidative analysis in Complex Regional Pain Syndrome
    Elon Eisenberg
    Pain Relief Unit, Rambam Medical Center, Bat Galim, Haifa, Israel
    Pain 138:226-32. 2008
    ..The accumulated data show that free radicals are involved in the pathophysiology of CRPS-I, which is reflected both in serum and salivary analyses. These data could be used for both diagnostic and therapeutic purposes in CRPS-I patients...