Silvia A Mandel

Summary

Affiliation: Technion-Israel Institute of Technology
Country: Israel

Publications

  1. ncbi request reprint Gene and protein expression profiles of anti- and pro-apoptotic actions of dopamine, R-apomorphine, green tea polyphenol (-)-epigallocatechine-3-gallate, and melatonin
    Orly Weinreb
    Eve Topf, Haifa, Israel
    Ann N Y Acad Sci 993:351-61; discussion 387-93. 2003
  2. pmc Epigallocatechin-3-gallate: a useful, effective and safe clinical approach for targeted prevention and individualised treatment of neurological diseases?
    Anja Mähler
    Experimental and Clinical Research Center, A Joint Cooperation between the Charité University Medicine Berlin and Max Delbrueck Center for Molecular Medicine, Berlin, D 13125, Germany
    EPMA J 4:5. 2013
  3. pmc Biomarkers for prediction and targeted prevention of Alzheimer's and Parkinson's diseases: evaluation of drug clinical efficacy
    Silvia A Mandel
    Eve Topf Center for Neurodegenerative Diseases Research and Department of Molecular Pharmacology, Faculty of Medicine, Technion, Haifa, Israel
    EPMA J 1:273-92. 2010
  4. doi request reprint Applying transcriptomic and proteomic knowledge to Parkinson's disease drug discovery
    Silvia Mandel
    Eve Topf Center for Neurodegenerative Diseases Research, Department of Pharmacology, Faculty of Medicine, Technion, Efron Street, PO Box 9697, Haifa 31096, Israel 972 4 8295289 972 4 8513145
    Expert Opin Drug Discov 2:1225-40. 2007
  5. ncbi request reprint In the rush for green gold: Can green tea delay age-progressive brain neurodegeneration?
    Silvia A Mandel
    Eve Topf Center of Excellence for Neurodegenerative Diseases Research and Department of Molecular Pharmacology, Faculty of Medicine, Technion, Haifa, Israel
    Recent Pat CNS Drug Discov 7:205-17. 2012
  6. pmc A molecular signature in blood identifies early Parkinson's disease
    Leonid Molochnikov
    Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
    Mol Neurodegener 7:26. 2012
  7. doi request reprint Targeting SKP1, an ubiquitin E3 ligase component found decreased in sporadic Parkinson's disease
    Silvia A Mandel
    Eve Topf Center for Neurodegenerative Diseases Research and Department of Molecular Pharmacology, Faculty of Medicine, Technion, Haifa, Israel
    Neurodegener Dis 10:220-3. 2012
  8. ncbi request reprint Molecular mechanisms of the neuroprotective/neurorescue action of multi-target green tea polyphenols
    Silvia A Mandel
    Eve Topf Center for Neurodegenerative Diseases Research and Department of Molecular Pharmacology, Faculty of Medicine, Technion, Haifa, Israel
    Front Biosci (Schol Ed) 4:581-98. 2012
  9. doi request reprint Modeling sporadic Parkinson's disease by silencing the ubiquitin E3 ligase component, SKP1A
    Silvia A Mandel
    Eve Topf Center for Neurodegenerative Diseases Research and Department of Molecular Pharmacology, Faculty of Medicine Technion, Haifa, Israel
    Parkinsonism Relat Disord 15:S148-51. 2009
  10. ncbi request reprint Green tea catechins as brain-permeable, natural iron chelators-antioxidants for the treatment of neurodegenerative disorders
    Silvia Mandel
    Eve Topf, Haifa, Israel
    Mol Nutr Food Res 50:229-34. 2006

Collaborators

Detail Information

Publications42

  1. ncbi request reprint Gene and protein expression profiles of anti- and pro-apoptotic actions of dopamine, R-apomorphine, green tea polyphenol (-)-epigallocatechine-3-gallate, and melatonin
    Orly Weinreb
    Eve Topf, Haifa, Israel
    Ann N Y Acad Sci 993:351-61; discussion 387-93. 2003
    ..We have shown that DA, R-APO, EGCG, and melatonin exhibit similar gene expression and protein profiles...
  2. pmc Epigallocatechin-3-gallate: a useful, effective and safe clinical approach for targeted prevention and individualised treatment of neurological diseases?
    Anja Mähler
    Experimental and Clinical Research Center, A Joint Cooperation between the Charité University Medicine Berlin and Max Delbrueck Center for Molecular Medicine, Berlin, D 13125, Germany
    EPMA J 4:5. 2013
    ..pro-oxidative properties of the tea catechin important for dosage recommendations...
  3. pmc Biomarkers for prediction and targeted prevention of Alzheimer's and Parkinson's diseases: evaluation of drug clinical efficacy
    Silvia A Mandel
    Eve Topf Center for Neurodegenerative Diseases Research and Department of Molecular Pharmacology, Faculty of Medicine, Technion, Haifa, Israel
    EPMA J 1:273-92. 2010
    ..In the long run the availability of reliable BMs will significantly advance the research and therapeutics of AD and PD...
  4. doi request reprint Applying transcriptomic and proteomic knowledge to Parkinson's disease drug discovery
    Silvia Mandel
    Eve Topf Center for Neurodegenerative Diseases Research, Department of Pharmacology, Faculty of Medicine, Technion, Efron Street, PO Box 9697, Haifa 31096, Israel 972 4 8295289 972 4 8513145
    Expert Opin Drug Discov 2:1225-40. 2007
    ..In addition, the application of transcriptomics and proteomics in the quest for multifunctional neuroprotective-neurorescue drugs that might possess disease-modifying action is discussed...
  5. ncbi request reprint In the rush for green gold: Can green tea delay age-progressive brain neurodegeneration?
    Silvia A Mandel
    Eve Topf Center of Excellence for Neurodegenerative Diseases Research and Department of Molecular Pharmacology, Faculty of Medicine, Technion, Haifa, Israel
    Recent Pat CNS Drug Discov 7:205-17. 2012
    ..To conclude, a future perspective on the utility and assigned patents with green tea constituents will be presented...
  6. pmc A molecular signature in blood identifies early Parkinson's disease
    Leonid Molochnikov
    Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
    Mol Neurodegener 7:26. 2012
    ..We aim to assess whether a gene signature could be detected in blood from early/mild PD patients that could support the diagnosis of early PD, focusing on genes found particularly altered in the substantia nigra of sporadic PD...
  7. doi request reprint Targeting SKP1, an ubiquitin E3 ligase component found decreased in sporadic Parkinson's disease
    Silvia A Mandel
    Eve Topf Center for Neurodegenerative Diseases Research and Department of Molecular Pharmacology, Faculty of Medicine, Technion, Haifa, Israel
    Neurodegener Dis 10:220-3. 2012
    ..Thus, strategies aimed at increasing the activity or content of Skp1 may represent a novel therapeutic approach that has the potential to treat PD...
  8. ncbi request reprint Molecular mechanisms of the neuroprotective/neurorescue action of multi-target green tea polyphenols
    Silvia A Mandel
    Eve Topf Center for Neurodegenerative Diseases Research and Department of Molecular Pharmacology, Faculty of Medicine, Technion, Haifa, Israel
    Front Biosci (Schol Ed) 4:581-98. 2012
    ....
  9. doi request reprint Modeling sporadic Parkinson's disease by silencing the ubiquitin E3 ligase component, SKP1A
    Silvia A Mandel
    Eve Topf Center for Neurodegenerative Diseases Research and Department of Molecular Pharmacology, Faculty of Medicine Technion, Haifa, Israel
    Parkinsonism Relat Disord 15:S148-51. 2009
    ....
  10. ncbi request reprint Green tea catechins as brain-permeable, natural iron chelators-antioxidants for the treatment of neurodegenerative disorders
    Silvia Mandel
    Eve Topf, Haifa, Israel
    Mol Nutr Food Res 50:229-34. 2006
    ....
  11. ncbi request reprint Targeting multiple neurodegenerative diseases etiologies with multimodal-acting green tea catechins
    Silvia A Mandel
    Eve Topf Center for Neurodegenerative Diseases Research and Department of Pharmacology, Faculty of Medicine, Technion, Haifa, Israel
    J Nutr 138:1578S-1583S. 2008
    ..This article elaborates on the multimodal activities of green tea polyphenols with emphasis on their recently described neurorescue/neuroregenerative and mitochondrial stabilization actions...
  12. doi request reprint Gene and protein signatures in sporadic Parkinson's disease and a novel genetic model of PD
    Silvia A Mandel
    Eve Topf Center for Neurodegenerative Diseases Research and Department of Pharmacology, Faculty of Medicine, Technion, Haifa, Israel
    Parkinsonism Relat Disord 13:S242-7. 2007
    ..The uncovered signatures may serve as future predictive biomarkers for early PD diagnosis, disease progression and drug development...
  13. ncbi request reprint Cell signaling pathways and iron chelation in the neurorestorative activity of green tea polyphenols: special reference to epigallocatechin gallate (EGCG)
    Silvia A Mandel
    Eve Topf Center for Neurodegenerative Diseases Research and Department of Pharmacology, Faculty of Medicine, Technion, Haifa, Israel
    J Alzheimers Dis 15:211-22. 2008
    ..This review provides a detailed overview on the multimodal activities of green tea polyphenols with emphasis on their iron chelating, neurorescue/neuroregenerative and mitochondrial stabilization action...
  14. doi request reprint Simultaneous manipulation of multiple brain targets by green tea catechins: a potential neuroprotective strategy for Alzheimer and Parkinson diseases
    Silvia A Mandel
    Eve Topf Center for Neurodegenerative Diseases Research and Department of Pharmacology, Faculty of Medicine, Technion, Haifa, Israel
    CNS Neurosci Ther 14:352-65. 2008
    ..In the current article, we review the literature on the impact of the multimodal activities of green tea polyphenols and their neuroprotective effect on AD and PD...
  15. doi request reprint Understanding the broad-spectrum neuroprotective action profile of green tea polyphenols in aging and neurodegenerative diseases
    Silvia A Mandel
    Eve Topf Center for Neurodegenerative Diseases Research and Department of Molecular Pharmacology, Faculty of Medicine, Technion, Haifa, Israel
    J Alzheimers Dis 25:187-208. 2011
    ....
  16. doi request reprint Genetic reduction of the E3 ubiquitin ligase element, SKP1A and environmental manipulation to emulate cardinal features of Parkinson's disease
    Silvia A Mandel
    Eve Topf Center for Neurodegenerative Diseases Research and Department of Molecular Pharmacology, Faculty of Medicine, Technion, Haifa, Israel
    Parkinsonism Relat Disord 18:S177-9. 2012
    ..To assess whether reduction of Skp1 will increase the vulnerability of dopaminergic neurons to genetic/environmental factors known to play a role in the pathological process of PD...
  17. doi request reprint Effects of novel neuroprotective and neurorestorative multifunctional drugs on iron chelation and glucose metabolism
    Yulia Pollak
    Pediatric Research and Electron Microscopy Unit, Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    J Neural Transm 120:37-48. 2013
    ..Such effects can have therapeutic significance in conditions with abnormal local or systemic iron metabolism, including neurological diseases...
  18. pmc A sporadic Parkinson disease model via silencing of the ubiquitin-proteasome/E3 ligase component SKP1A
    Tali Fishman-Jacob
    Eve Topf and National Parkinson Foundation Centers for Neurodegenerative Diseases and the Department of Molecular Pharmacology, Faculty of Medicine, Technion, 31096 Haifa, Israel
    J Biol Chem 284:32835-45. 2009
    ..In summary, this new model has reproduced to a significant extent the molecular alterations described in sporadic PD at the cellular level, implicating Skp1 as a potential modifier in sporadic PD neurodegeneration...
  19. ncbi request reprint Multifunctional activities of green tea catechins in neuroprotection. Modulation of cell survival genes, iron-dependent oxidative stress and PKC signaling pathway
    Silvia A Mandel
    Eve Topf and USA National Parkinson Foundation Centers of Excellence for Neurodegenerative Diseases Research, Technion Faculty of Medicine, Haifa, Israel
    Neurosignals 14:46-60. 2005
    ..In particular, their transitional metal (iron and copper) chelating property and inhibition of oxidative stress...
  20. doi request reprint Low dosage of rasagiline and epigallocatechin gallate synergistically restored the nigrostriatal axis in MPTP-induced parkinsonism
    Lydia Reznichenko
    Eve Topf Center for Neurodegenerative Diseases Research and Department of Molecular Pharmacology, Faculty of Medicine, Technion, Haifa, Israel
    Neurodegener Dis 7:219-31. 2010
    ..This may have important implications for rasagiline-treated PD patients who could further benefit from an adjunct administration of EGCG...
  21. doi request reprint Neuroprotective profile of the multitarget drug rasagiline in Parkinson's disease
    Orly Weinreb
    Eve Topf Centre of Excellence for Neurodegenerative Diseases and Department of Molecular Pharmacology, Technion Rappaport Faculty of Medicine, Efron Street, P O Box 9697, Haifa, Israel
    Int Rev Neurobiol 100:127-49. 2011
    ..This review reflects on earlier and present evidence supporting a role for rasagiline as a neuroprotective molecule in the treatment of PD...
  22. ncbi request reprint Green tea polyphenol (-) -epigallocatechin-3-gallate promotes the rapid protein kinase C- and proteasome-mediated degradation of Bad: implications for neuroprotection
    Limor Kalfon
    Eve Topf Center for Neurodegenerative Diseases, and Department of Pharmacology, Faculty of Medicine, Technion, Haifa, Israel
    J Neurochem 100:992-1002. 2007
    ..6-fold). The present study reveals a novel pathway in the neuroprotective mechanism of the action of EGCG, which involves a rapid PKC-mediated degradation of Bad by the proteasome...
  23. doi request reprint The novel multifunctional, iron-chelating drugs M30 and HLA20 protect pancreatic beta-cell lines from oxidative stress damage
    Danit Mechlovich
    Eve Topf Center of Excellence for Neurodegenerative Diseases Research and Department of Molecular Pharmacology, Rappaport Faculty of Medicine, Technion, Israel
    J Pharmacol Exp Ther 333:874-82. 2010
    ....
  24. ncbi request reprint Rasagiline promotes regeneration of substantia nigra dopaminergic neurons in post-MPTP-induced Parkinsonism via activation of tyrosine kinase receptor signaling pathway
    Silvia A Mandel
    Eve Topf Center of Excellence for Neurodegenerative Diseases Research, Department of Pharmacology, Technion Rappaport Faculty of Medicine, P O Box 9697, Haifa, 31096, Israel
    Neurochem Res 32:1694-9. 2007
    ..It is interesting to determine whether a similar effect is seen in Parkinsonian patients after long-term treatment with rasagiline, which may have implications as a possible disease modifying agent...
  25. doi request reprint Silencing/overexpressing selected genes as a model of sporadic Parkinson's disease
    Tali Fishman-Jacob
    Eve Topf Center for Neurodegenerative Diseases Research and Department of Molecular Pharmacology, Faculty of Medicine, Technion, Haifa, Israel
    Neurodegener Dis 7:108-11. 2010
    ....
  26. ncbi request reprint Iron and alpha-synuclein in the substantia nigra of MPTP-treated mice: effect of neuroprotective drugs R-apomorphine and green tea polyphenol (-)-epigallocatechin-3-gallate
    Silvia Mandel
    Eve Topf and USA National Parkinson Foundation Centers of Excellence for Neurodegenerative Diseases Research and Department of Pharmacology and Rappaport Family Research Institute, Technion Faculty of Medicine, Haifa, 31096, Israel
    J Mol Neurosci 24:401-16. 2004
    ..This study supports the notion that a combination of iron chelation and antioxidant therapy, as emphasized on several occasions, might be a significant approach to neuroprotection in PD and other neurodegenerative diseases...
  27. doi request reprint Iron-chelating backbone coupled with monoamine oxidase inhibitory moiety as novel pluripotential therapeutic agents for Alzheimer's disease: a tribute to Moussa Youdim
    Orly Weinreb
    Eve Topf Centers of Excellence for Neurodegenerative Diseases Research and Department of Pharmacology, Rappaport Family Research Institute, Technion Faculty of Medicine, P O B 9697, 31096, Haifa, Israel
    J Neural Transm 118:479-92. 2011
    ....
  28. ncbi request reprint Attenuation of 6-hydroxydopamine (6-OHDA)-induced nuclear factor-kappaB (NF-kappaB) activation and cell death by tea extracts in neuronal cultures
    Yona Levites
    Eve Topf and USA National Parkinson Foundation Centers of Excellence for Neurodegenerative Diseases Research, Technion Faculty of Medicine, Haifa, Israel
    Biochem Pharmacol 63:21-9. 2002
    ..Brain penetrating property of polyphenols may make such compounds an important class of drugs for treatment of neurodegenerative diseases...
  29. ncbi request reprint Genes and oxidative stress in parkinsonism: cDNA microarray studies
    Silvia Mandel
    Eve Topf and U S National Parkinson s Foundation Centers of Excellence for Neurodegenerative Diseases, Bruce Rappaport Family Research Institute, Department of Pharmacology, Faculty of Medicine, Technion, Haifa, Israel
    Adv Neurol 91:123-32. 2003
  30. doi request reprint Neuroprotective multifunctional iron chelators: from redox-sensitive process to novel therapeutic opportunities
    Orly Weinreb
    Eve Topf Centers of Excellence for Neurodegenerative Diseases Research and Department of Pharmacology, Rappaport Family Research Institute, Technion Faculty of Medicine, Haifa, Israel
    Antioxid Redox Signal 13:919-49. 2010
    ..This review discusses two interrelated approaches concerning therapy targets in neurodegeneration, sharing in common the implementation of iron chelation activity: antioxidation and HIF-1-pathway activation...
  31. ncbi request reprint cDNA gene expression profile homology of antioxidants and their antiapoptotic and proapoptotic activities in human neuroblastoma cells
    Orly Weinreb
    Department of Pharmacology, Technion Faculty of Medicine, P O B 9697, 31096 Haifa, Israel
    FASEB J 17:935-7. 2003
    ..Our results provide for the first time new insights into the molecular events involved in the dose-dependent neuroprotective and neurotoxic activities of catechols and indole amine compounds...
  32. doi request reprint Multifunctional neuroprotective derivatives of rasagiline as anti-Alzheimer's disease drugs
    Orly Weinreb
    Eve Topf and USA National Parkinson Foundation Centers of Excellence for Neurodegenerative Diseases Research and Department of Pharmacology, Rappaport Family Research Institute, Technion Faculty of Medicine, Haifa, 31096, Israel
    Neurotherapeutics 6:163-74. 2009
    ..Altogether, these scientific findings make these multifunctional compounds potentially valuable drugs for the treatment of Alzheimer's disease...
  33. ncbi request reprint Targeting multiple Alzheimer's disease etiologies with multimodal neuroprotective and neurorestorative iron chelators
    Tamar Amit
    Eve Topf Center of Excellence for Neurodegenerative Diseases Research, Department of Pharmacology, Faculty of Medicine, Technion, Faculty of Medicine, Haifa, Israel
    FASEB J 22:1296-305. 2008
    ..A similar approach in drug design is being investigated for treatment of cancer, AIDS, cardiovascular diseases, and depression...
  34. ncbi request reprint Neuroprotection and neurorescue against Abeta toxicity and PKC-dependent release of nonamyloidogenic soluble precursor protein by green tea polyphenol (-)-epigallocatechin-3-gallate
    Yona Levites
    Eve Topf and USA National Parkinson Foundation, Centers of Excellence for Neurodegenerative Diseases Research, Technion Faculty of Medicine, Haifa, Israel
    FASEB J 17:952-4. 2003
    ..Thus, EGCG has protective effects against Abeta-induced neurotoxicity and regulates secretory processing of non-amyloidogenic APP via PKC pathway...
  35. ncbi request reprint Cell signaling pathways in the neuroprotective actions of the green tea polyphenol (-)-epigallocatechin-3-gallate: implications for neurodegenerative diseases
    Silvia Mandel
    Eve Topf and USA National Parkinson Foundation Centers of Excellence for Neurodegenerative Diseases Research and Department of Pharmacology, Technion Faculty of Medicine, Haifa, Israel
    J Neurochem 88:1555-69. 2004
    ....
  36. doi request reprint Metallocorroles as cytoprotective agents against oxidative and nitrative stress in cellular models of neurodegeneration
    Lana Kupershmidt
    Eve Topf and USA National Parkinson Foundation Centers of Excellence for Neurodegenerative Diseases Research and Department of Pharmacology, Faculty of Medicine, Rappaport Family Research Institute, Technion Israel Institute of Technology, Haifa, 31096, Israel
    J Neurochem 113:363-73. 2010
    ..These results highlight the large potential of corrole complexes as novel agents for therapeutic approaches in degenerative disorders of the central and peripheral nervous systems, where oxidative and nitrative stresses are involved...
  37. ncbi request reprint Gene expression profiling of sporadic Parkinson's disease substantia nigra pars compacta reveals impairment of ubiquitin-proteasome subunits, SKP1A, aldehyde dehydrogenase, and chaperone HSC-70
    Silvia Mandel
    Eve Topf and USA National Parkinson Foundation Centers of Excellence and Department of Pharmacology, Family Research Institute, Technion Rappaport Family Faculty of Medicine, Haifa, Israel
    Ann N Y Acad Sci 1053:356-75. 2005
    ....
  38. ncbi request reprint Neurorescue activity, APP regulation and amyloid-beta peptide reduction by novel multi-functional brain permeable iron- chelating- antioxidants, M-30 and green tea polyphenol, EGCG
    Yael Avramovich-Tirosh
    Eve Topf and USA NPF Centers of Excellence, Technion Rappaport Family Faculty of Medicine and Department of Pharmacology, Haifa, Israel
    Curr Alzheimer Res 4:403-11. 2007
    ....
  39. doi request reprint Neuroprotective and neuritogenic activities of novel multimodal iron-chelating drugs in motor-neuron-like NSC-34 cells and transgenic mouse model of amyotrophic lateral sclerosis
    Lana Kupershmidt
    Eve Topf and USA National Parkinson Foundation Centers of Excellence for Neurodegenerative Diseases Research, Haifa, Israel
    FASEB J 23:3766-79. 2009
    ..These properties of the novel multimodal iron-chelating drugs possessing neuroprotective/neuritogenic activities may offer future therapeutic possibilities for motor neurodegenerative diseases...
  40. ncbi request reprint Proceedings from the "Third International Conference on Mechanism of Action of Nutraceuticals"
    Silvia Mandel
    Eve Topf, USA National Parkinson Foundation Centers of Excellence for Neurodegenerative Diseases Research, Rappaport Family Research Institute, Technion Faculty of Medicine, Haifa 31096, Israel
    J Nutr Biochem 16:513-20. 2005
    ..This review summarizes the latest research finding in functional foods and micronutrients in the promotion of health and reduction of risk for major chronic diseases as presented in this symposium...
  41. ncbi request reprint Neuroprotective strategies in Parkinson's disease : an update on progress
    Silvia Mandel
    Department of Pharmacology, Technion Faculty of Medicine, Eve Topf and US National Parkinson s Foundation Centers for Neurodegenerative Diseases, Bruce Rappaport Family Research Institute, Haifa, Israel
    CNS Drugs 17:729-62. 2003
    ..Even with the advent of powerful new tools such as genomics, proteomics, brain imaging, gene replacement therapy and knockout animal models, the desired end result of neuroprotection is still beyond our current capability...
  42. ncbi request reprint Early and late gene changes in MPTP mice model of Parkinson's disease employing cDNA microarray
    Silvia Mandel
    Eye Topf and U S National Parkinson s Foundation Centers of Excellence for Neurodegenerative Diseases, Bruce Rappaport Family Research Institute and Department of Pharmacology, Haifa, Israel
    Neurochem Res 27:1231-43. 2002
    ..The time course of these gene expression changes indicates the importance of investigating the early gene cascade of events occurring prior to late nigrostriatal dopamine neuronal cell death...