Lena Lavie

Summary

Affiliation: Technion-Israel Institute of Technology
Country: Israel

Publications

  1. ncbi request reprint Obstructive sleep apnoea syndrome--an oxidative stress disorder
    Lena Lavie
    Anatomy and Cell Biology, Bruce Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    Sleep Med Rev 7:35-51. 2003
  2. pmc Bax/Mcl-1 balance affects neutrophil survival in intermittent hypoxia and obstructive sleep apnea: effects of p38MAPK and ERK1/2 signaling
    Larissa Dyugovskaya
    The Lloyd Rigler Sleep Apnea Research Laboratory, The Ruth and Bruce Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    J Transl Med 10:211. 2012
  3. ncbi request reprint Smoking interacts with sleep apnea to increase cardiovascular risk
    Lena Lavie
    Lloyd Rigler Sleep Apnea Research Laboratory Ruth and Bruce Rappaport, Faculty of Medicine, Technion Israel Institute of Technology, Efron Street 7, Bat Galim, Haifa, Israel
    Sleep Med 9:247-53. 2008
  4. doi request reprint Endothelial progenitor cells in acute myocardial infarction and sleep-disordered breathing
    Slava Berger
    The Lloyd Rigler Sleep Apnea Research Laboratory, Unit of Anatomy and Cell Biology, The Ruth and Bruce Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    Am J Respir Crit Care Med 187:90-8. 2013
  5. doi request reprint Short-term fibronectin treatment induces endothelial-like and angiogenic properties in monocyte-derived immature dendritic cells: involvement of intracellular VEGF and MAPK regulation
    Slava Berger
    The Lloyd Rigler Sleep Apnea Research Laboratory, Unit of Anatomy and Cell Biology, The Ruth and Bruce Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    Eur J Cell Biol 91:640-53. 2012
  6. doi request reprint Unexpected survival advantage in elderly people with moderate sleep apnoea
    Peretz Lavie
    Lloyd Rigler Sleep Apnea Research Laboratory, Ruth and Bruce Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    J Sleep Res 18:397-403. 2009
  7. ncbi request reprint Biology of peripheral blood cells in obstructive sleep apnea--the tip of the iceberg
    Lena Lavie
    Lloyd Rigler Sleep Apnea Research Laboratory, Unit of Anatomy and Cell Biology, The Ruth and Bruce Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    Arch Physiol Biochem 114:244-54. 2008
  8. doi request reprint Heat-shock protein 70: expression in monocytes of patients with sleep apnoea and association with oxidative stress and tumour necrosis factor-alpha
    Lena Lavie
    Lloyd Rigler Sleep Apnea Research Laboratory, Unit of Anatomy and Cell Biology, The Bruce Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    J Sleep Res 19:139-47. 2010
  9. ncbi request reprint Mortality risk factors in sleep apnoea: a matched case-control study
    Peretz Lavie
    Lloyd Rigler Sleep Apnea Research Laboratory, Ruth and Bruce Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    J Sleep Res 16:128-34. 2007
  10. ncbi request reprint Evidence for lipid peroxidation in obstructive sleep apnea
    Lena Lavie
    The Lloyd Rigler Sleep Apnea Research Laboratory, The Bruce Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    Sleep 27:123-8. 2004

Collaborators

Detail Information

Publications43

  1. ncbi request reprint Obstructive sleep apnoea syndrome--an oxidative stress disorder
    Lena Lavie
    Anatomy and Cell Biology, Bruce Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    Sleep Med Rev 7:35-51. 2003
    ..Cumulatively, these processes may exacerbate atherogenic sequelae in OSA...
  2. pmc Bax/Mcl-1 balance affects neutrophil survival in intermittent hypoxia and obstructive sleep apnea: effects of p38MAPK and ERK1/2 signaling
    Larissa Dyugovskaya
    The Lloyd Rigler Sleep Apnea Research Laboratory, The Ruth and Bruce Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    J Transl Med 10:211. 2012
    ..Specifically, the balance between pro-apoptotic Bax and anti-apoptotic Mcl-1 protein expression, and the potential involvement of p38MAPK and ERK1/2 signaling pathways in the control of Mcl-1 expression were investigated...
  3. ncbi request reprint Smoking interacts with sleep apnea to increase cardiovascular risk
    Lena Lavie
    Lloyd Rigler Sleep Apnea Research Laboratory Ruth and Bruce Rappaport, Faculty of Medicine, Technion Israel Institute of Technology, Efron Street 7, Bat Galim, Haifa, Israel
    Sleep Med 9:247-53. 2008
    ..We investigated oxidative stress and inflammatory markers in 70 non-smoking and smoking patients with sleep apnea...
  4. doi request reprint Endothelial progenitor cells in acute myocardial infarction and sleep-disordered breathing
    Slava Berger
    The Lloyd Rigler Sleep Apnea Research Laboratory, Unit of Anatomy and Cell Biology, The Ruth and Bruce Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    Am J Respir Crit Care Med 187:90-8. 2013
    ..Mobilization and functions of endothelial progenitor cells (EPCs) are increased in patients with acute myocardial infarction (AMI). Yet, sleep-disordered breathing (SDB) is highly prevalent in patients with AMI...
  5. doi request reprint Short-term fibronectin treatment induces endothelial-like and angiogenic properties in monocyte-derived immature dendritic cells: involvement of intracellular VEGF and MAPK regulation
    Slava Berger
    The Lloyd Rigler Sleep Apnea Research Laboratory, Unit of Anatomy and Cell Biology, The Ruth and Bruce Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    Eur J Cell Biol 91:640-53. 2012
    ..Collectively, these findings may support a role for FN and Mo-iDCs in vascular function and angiogenesis...
  6. doi request reprint Unexpected survival advantage in elderly people with moderate sleep apnoea
    Peretz Lavie
    Lloyd Rigler Sleep Apnea Research Laboratory, Ruth and Bruce Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    J Sleep Res 18:397-403. 2009
    ....
  7. ncbi request reprint Biology of peripheral blood cells in obstructive sleep apnea--the tip of the iceberg
    Lena Lavie
    Lloyd Rigler Sleep Apnea Research Laboratory, Unit of Anatomy and Cell Biology, The Ruth and Bruce Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    Arch Physiol Biochem 114:244-54. 2008
    ..However, inter-individual differences in response to intermittent hypoxia and activation of anti-inflammatory cytokine profiles in T lymphocytes can serve as protective mechanisms...
  8. doi request reprint Heat-shock protein 70: expression in monocytes of patients with sleep apnoea and association with oxidative stress and tumour necrosis factor-alpha
    Lena Lavie
    Lloyd Rigler Sleep Apnea Research Laboratory, Unit of Anatomy and Cell Biology, The Bruce Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    J Sleep Res 19:139-47. 2010
    ..Correlations with oxidative stress and TNF-alpha further support this conclusion...
  9. ncbi request reprint Mortality risk factors in sleep apnoea: a matched case-control study
    Peretz Lavie
    Lloyd Rigler Sleep Apnea Research Laboratory, Ruth and Bruce Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    J Sleep Res 16:128-34. 2007
    ..We conclude that all-cause mortality in sleep apnoea is associated with co-morbidities and obesity. Severity of sleep apnoea affects mortality by interacting with obesity and lung disease...
  10. ncbi request reprint Evidence for lipid peroxidation in obstructive sleep apnea
    Lena Lavie
    The Lloyd Rigler Sleep Apnea Research Laboratory, The Bruce Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    Sleep 27:123-8. 2004
    ....
  11. ncbi request reprint Plasma vascular endothelial growth factor in sleep apnea syndrome: effects of nasal continuous positive air pressure treatment
    Lena Lavie
    Unit of Anatomy and Cell Biology, Bruce Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    Am J Respir Crit Care Med 165:1624-8. 2002
    ..9 +/- 23.6 versus 54.0 +/- 21.5 pg/ml, ns). These results raise the possibility that VEGF may contribute to the long-term adaptation of sleep apnea syndrome to recurrent nocturnal hypoxia...
  12. ncbi request reprint Elevated plasma homocysteine in older shift-workers: a potential risk factor for cardiovascular morbidity
    Lena Lavie
    Ruth and Bruce Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    Chronobiol Int 24:115-28. 2007
    ..The elevated homocysteine levels may play a role in the increased rates of cardiovascular morbidity in shift-workers, and they may have practical implications regarding the nutrition of shift-workers...
  13. ncbi request reprint Sleep-disordered breathing and cerebrovascular disease: a mechanistic approach
    Lena Lavie
    The Lloyd Rigler Sleep Apnea Research Laboratory, Unit of Anatomy and Cell Biology, The Ruth and Bruce Rappaport Faculty of Medicine, Technion Israel Institute of Technology, POB 9649, 31096, Haifa, Israel
    Neurol Clin 23:1059-75. 2005
    ..These may be exaggerated in patients who have sleep apnea in response to the intermittent hypoxia...
  14. ncbi request reprint Haptoglobin polymorphism is a risk factor for cardiovascular disease in patients with obstructive sleep apnea syndrome
    Lena Lavie
    Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    Sleep 26:592-5. 2003
    ..We therefore sought to determine if the haptoglobin phenotype was a determinant of cardiovascular disease in patients with obstructive sleep apnea syndrome...
  15. ncbi request reprint Cardiovascular aspects in obstructive sleep apnea syndrome--molecular issues, hypoxia and cytokine profiles
    Lena Lavie
    Lloyd Rigler Sleep Apnea Research Laboratory, Unit of Anatomy and Cell Biology, The Bruce Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    Respiration 78:361-70. 2009
    ..In light of the new findings in the field of cytokines, their potential involvement in endothelial dysfunction and cardiovascular morbidity in OSAS is discussed...
  16. ncbi request reprint Lymphocyte activation as a possible measure of atherosclerotic risk in patients with sleep apnea
    Larissa Dyugovskaya
    Lloyd Rigler Sleep Apnea Research Laboratory, Unit of Anatomy and Cell Biology, The Ruth and Bruce Rappaport Faculty of Medicine, Technion Israel Institute of Technology, 31096 Haifa, Israel
    Ann N Y Acad Sci 1051:340-50. 2005
    ..In conclusion, increased cytotoxicity and cytokine imbalance in CD4 and CD8 T cells may be involved in atherogenesis in OSA. Nasal CPAP treatment ameliorates some lymphocyte dysfunctions and thus may moderate some atherogenic pathways...
  17. doi request reprint Oxidative stress--a unifying paradigm in obstructive sleep apnea and comorbidities
    Lena Lavie
    Lloyd Rigler Sleep Apnea Research Laboratory, Unit of Anatomy and Cell Biology, The Bruce Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    Prog Cardiovasc Dis 51:303-12. 2009
    ..If left untreated, this cascade of events may eventually lead to overt cardiovascular morbidity...
  18. ncbi request reprint Ischemic preconditioning as a possible explanation for the age decline relative mortality in sleep apnea
    Lena Lavie
    Lloyd Rigler Sleep Apnea Research Laboratory, Ruth and Bruce Rappaport Faculty of Medicine, Rappaport Building, Technion Israel Institute of Technology, Bat Galim, Haifa
    Med Hypotheses 66:1069-73. 2006
    ....
  19. doi request reprint Circadian pattern of life-threatening ventricular arrhythmia in patients with sleep-disordered breathing and implantable cardioverter-defibrillators
    Tawfiq Zeidan-Shwiri
    Department of Cardiology, Rambam Medical Center, Haifa, Israel
    Heart Rhythm 8:657-62. 2011
    ..Sleep-disordered breathing (SDB) has been associated with various benign cardiac arrhythmias occurring during sleep...
  20. ncbi request reprint Endothelial dysfunction in obstructive sleep apnea measured by peripheral arterial tone response in the finger to reactive hyperemia
    Sarah Itzhaki
    Lloyd Rigler Sleep Apnea Research Laboratory, Ruth and Bruce Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    Sleep 28:594-600. 2005
    ..The aim of this study was to investigate endothelial functioning in sleep apnea patients using a novel plethysmographic device that monitors peripheral arterial tone response in the finger to reactive hyperemia induced by forearm ischemia...
  21. ncbi request reprint Plasma levels of nitric oxide and L-arginine in sleep apnea patients: effects of nCPAP treatment
    Lena Lavie
    Unit of Anatomy and Cell Biology, Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    J Mol Neurosci 21:57-63. 2003
    ..These results demonstrate that sleep apnea is associated with a chronic state of diminished circulating NO concentrations that can be ameliorated by nCPAP treatment...
  22. doi request reprint Molecular pathways of spontaneous and TNF-{alpha}-mediated neutrophil apoptosis under intermittent hypoxia
    Larissa Dyugovskaya
    Unit of Anatomy and Cell Biology, The Ruth and Bruce Rappaport Faculty of Medicine, Technion, POB 9649, 31096, Haifa, Israel
    Am J Respir Cell Mol Biol 45:154-62. 2011
    ..Collectively, these findings provide insights into the mechanisms that prolong PMN survival after IH exposure and demonstrate the essential role played by NF-κB, the p38MAPK signaling pathway, and downstream genes in this process...
  23. ncbi request reprint Intermittent hypoxia: the culprit of oxidative stress, vascular inflammation and dyslipidemia in obstructive sleep apnea
    Lena Lavie
    Unit of Anatomy and Cell Biology, The Ruth and Bruce Rappaport Faculty of Medicine, Technion, PO Box 9649, 31096, Haifa, Israel
    Expert Rev Respir Med 2:75-84. 2008
    ..If left untreated, this cascade of events may eventually lead to overt cardiovascular morbidity...
  24. pmc Clinical implications of sleep disordered breathing in acute myocardial infarction
    Doron Aronson
    Department of Cardiology, Rambam Medical Center, Haifa, Israel
    PLoS ONE 9:e88878. 2014
    ..This prospective study investigated whether the metabolic perturbations associated with SDB are present when these patients develop AMI and if they affect clinical outcomes...
  25. ncbi request reprint The development of giant phagocytes in long-term neutrophil cultures
    Larissa Dyugovskaya
    The Lloyd Rigler Sleep Apnea Research Laboratory, Unit of Anatomy and Cell Biology, The Ruth and Bruce Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    J Leukoc Biol . 2014
    ..This may lead to cell adaptation and survival, resulting in their transformation into long-lived Gϕ and potentially suggesting their involvement in inflammatory/anti-inflammatory processes...
  26. ncbi request reprint Oxidative stress inflammation and endothelial dysfunction in obstructive sleep apnea
    Lena Lavie
    Lloyd Rigler Sleep Apnea Research Laboratory, Unit of Anatomy and Cell Biology, The Ruth and Bruce Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    Front Biosci (Elite Ed) 4:1391-403. 2012
    ....
  27. doi request reprint Endothelial progenitor cells in cardiovascular disease and hypoxia--potential implications to obstructive sleep apnea
    Slava Berger
    Lloyd Rigler Sleep Apnea Research Laboratory, Unit of Anatomy and Cell Biology, The Bruce and Ruth Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    Transl Res 158:1-13. 2011
    ..The current review highlights the potential role of EPCs in the pathogenesis of vascular diseases that is pertinent to OSA...
  28. ncbi request reprint Endothelial cell dysfunction in women with cardiac syndrome X and MTHFR C677T mutation
    Sharon Alroy
    Department of Cardiovascular Medicine, Lady Davis Carmel Medical Center, Haifa, Israel
    Isr Med Assoc J 9:321-5. 2007
    ..Multiple factors are implicated in the pathophysiology, including elevated levels of homocysteine in the blood. Mutations in the MTHFR gene are associated with elevated levels of homocysteine...
  29. ncbi request reprint Cardiovascular morbidity and mortality in obstructive sleep apnea
    Peretz Lavie
    Lloyd Rigler Sleep Apnea Research Laboratory, B Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    Curr Pharm Des 14:3466-73. 2008
    ..Results demonstrating that effective treatment of the syndrome can abort and even reverse the atherogenic process suggest that OSA should be diagnosed and treated as early as possible in order to prevent cardiovascular sequlea...
  30. ncbi request reprint Relation of C-reactive protein to coronary collaterals in patients with stable angina pectoris and coronary artery disease
    Arthur Kerner
    Department of Cardiology, Rambam Medical Center, Haifa, Israel
    Am J Cardiol 99:509-12. 2007
    ..15 to 0.75; p = 0.008) for patients in the third CRP tertile (p for trend = 0.008). In conclusion, an inverse graded association exists between CRP and the presence of coronary collaterals in patients with stable angina pectoris...
  31. ncbi request reprint Increased adhesion molecules expression and production of reactive oxygen species in leukocytes of sleep apnea patients
    Larissa Dyugovskaya
    Unit of Anatomy and Cell Biology and Sleep Laboratory, Technion Israel Institute of Technology, The Bruce Rappaport Faculty of Medicine, Haifa, Israel
    Am J Respir Crit Care Med 165:934-9. 2002
    ..Monocyte adherence to endothelial cells decreased as well. Our findings provide one of the possible mechanisms for explaining the high rate of cardiovascular morbidity in patients with sleep apnea...
  32. ncbi request reprint Decreased pituitary-gonadal secretion in men with obstructive sleep apnea
    Rafael Luboshitzky
    Endocrine Institute, Haemek Medical Center, Afula 18101, Israel
    J Clin Endocrinol Metab 87:3394-8. 2002
    ....
  33. ncbi request reprint Phenotypic and functional characterization of blood gammadelta T cells in sleep apnea
    Larissa Dyugovskaya
    Unit of Anatomy and Cell Biology, The Bruce Rappaport Faculty of Medicine, Technion, POB 9649, 31096 Haifa, Israel
    Am J Respir Crit Care Med 168:242-9. 2003
    ..5-fold higher than that of control subjects and could be prevented by pretreatment with anti-TNF-alpha. Collectively these data implicate gammadelta T lymphocyte function in atherogenic sequelae in OSA...
  34. ncbi request reprint The effects of 1-year treatment with a herbst mandibular advancement splint on obstructive sleep apnea, oxidative stress, and endothelial function
    Sarah Itzhaki
    Sleep Laboratory, Rambam Medical Center, Haifa 31096, Israel
    Chest 131:740-9. 2007
    ..In the current study, we assessed the effect of long-term modified Herbst mandibular advancement splint (MAS) treatment on OSA, oxidative stress markers, and on endothelial function (EF)...
  35. ncbi request reprint Sleep apnea syndrome, endothelial dysfunction, and cardiovascular morbidity
    Lena Lavie
    Sleep 27:1053-5. 2004
  36. ncbi request reprint Obstructive sleep apnoea and plasma homocysteine
    Lena Lavie
    Eur Heart J 26:526-7. 2005
  37. ncbi request reprint Delayed neutrophil apoptosis in patients with sleep apnea
    Larissa Dyugovskaya
    Unit of Anatomy and Cell Biology, The Ruth and Bruce Rappaport Faculty of Medicine, Technion, POB 9649, 31096 Haifa, Israel
    Am J Respir Crit Care Med 177:544-54. 2008
    ..PMN apoptosis is a fundamental, injury-limiting mechanism, which prevents their destructive potential...
  38. ncbi request reprint Sleep-apnea-related intermittent hypoxia and atherogenesis: adhesion molecules and monocytes/endothelial cells interactions
    Lena Lavie
    Atherosclerosis 183:183-4. 2005
  39. ncbi request reprint Obstructive sleep apnoea and plasma homocysteine
    Lena Lavie
    Eur Heart J 26:2210; author reply 2210-1. 2005
  40. ncbi request reprint Pituitary-gonadal function in men with obstructive sleep apnea. The effect of continuous positive airways pressure treatment
    Rafael Luboshitzky
    Endocrine Institute, Haemek Medical Center, Afula 18101, Israel
    Neuro Endocrinol Lett 24:463-7. 2003
    ..Our study aimed to evaluate the pituitary-gonadal axis in middle age men with OSA before and after treatment with nasal continuous positive airway pressure (CPAP)...
  41. ncbi request reprint Risk factors for cardiovascular disease in women with subclinical hypothyroidism
    Rafael Luboshitzky
    Endocrine Institute, Haemek Medical Center, Afula, Israel
    Thyroid 12:421-5. 2002
    ..This may increase the risk of accelerated atherosclerosis and premature coronary artery disease in some patients...
  42. ncbi request reprint Is the severity of sleep apnea associated with ischemic stroke in the elderly?
    Peretz Lavie
    Stroke 38:249; author reply 250. 2007
  43. ncbi request reprint Altered luteinizing hormone and testosterone secretion in middle-aged obese men with obstructive sleep apnea
    Rafael Luboshitzky
    Endocrine Institute, Haemek Medical Center, Afula 18101, Israel
    Obes Res 13:780-6. 2005
    ..To elucidate the causes for the decline in testosterone levels observed in men with obstructive sleep apnea (OSA)...