M H Glickman

Summary

Affiliation: Technion-Israel Institute of Technology
Country: Israel

Publications

  1. ncbi request reprint The ubiquitin-proteasome proteolytic pathway: destruction for the sake of construction
    Michael H Glickman
    Faculty of Biology and the Institute for Catalysis Science and Technology, Haifa, Israel
    Physiol Rev 82:373-428. 2002
  2. pmc MPN+, a putative catalytic motif found in a subset of MPN domain proteins from eukaryotes and prokaryotes, is critical for Rpn11 function
    Vered Maytal-Kivity
    Dept of Biology, Institute for Catalysis Science and Technology Technion Israel Institute of Technology, Israel
    BMC Biochem 3:28. 2002
  3. ncbi request reprint Getting in and out of the proteasome
    M H Glickman
    Department of Biology, The Technion Israel Institute of Technology, Haifa
    Semin Cell Dev Biol 11:149-58. 2000
  4. pmc The proteasome and the delicate balance between destruction and rescue
    Michael H Glickman
    Department of Biology, Technion Israel Institute of Technology in Haifa, Israel
    PLoS Biol 2:E13. 2004
  5. ncbi request reprint The COP9 signalosome-like complex in S. cerevisiae and links to other PCI complexes
    Vered Maytal-Kivity
    Department of Biology and Institute for Catalysis Science and Technology ICST, Technion Israel Institute of Technology, 32000, Haifa, Israel
    Int J Biochem Cell Biol 35:706-15. 2003
  6. ncbi request reprint Keepers at the final gates: regulatory complexes and gating of the proteasome channel
    M Bajorek
    Department of Biology and the Institute for Catalysis Science and Technology, Technion Israel Institute of Technology, Haifa, Israel
    Cell Mol Life Sci 61:1579-88. 2004
  7. ncbi request reprint Regulating the 26S proteasome
    M H Glickman
    Department of Biology, The Technion, Israel Institute of Technology, 32000 Haifa, Israel
    Curr Top Microbiol Immunol 268:43-72. 2002
  8. pmc Extraproteasomal Rpn10 restricts access of the polyubiquitin-binding protein Dsk2 to proteasome
    Yulia Matiuhin
    Department of Biology, Technion Israel Institute of Technology, Haifa 32000, Israel
    Mol Cell 32:415-25. 2008
  9. ncbi request reprint Proteasome disassembly and downregulation is correlated with viability during stationary phase
    Monika Bajorek
    Department of Biology, The Technion Israel Institute of Technology, 32000 Haifa, Israel
    Curr Biol 13:1140-4. 2003
  10. pmc The central unit within the 19S regulatory particle of the proteasome
    Rina Rosenzweig
    Department of Biology, Technion Israel Institute of Technology, 32000 Haifa, Israel
    Nat Struct Mol Biol 15:573-80. 2008

Collaborators

Detail Information

Publications21

  1. ncbi request reprint The ubiquitin-proteasome proteolytic pathway: destruction for the sake of construction
    Michael H Glickman
    Faculty of Biology and the Institute for Catalysis Science and Technology, Haifa, Israel
    Physiol Rev 82:373-428. 2002
    ..Among these are the modes of specific and timed recognition for the degradation of the many substrates and the mechanisms that underlie aberrations in the system that lead to pathogenesis of diseases...
  2. pmc MPN+, a putative catalytic motif found in a subset of MPN domain proteins from eukaryotes and prokaryotes, is critical for Rpn11 function
    Vered Maytal-Kivity
    Dept of Biology, Institute for Catalysis Science and Technology Technion Israel Institute of Technology, Israel
    BMC Biochem 3:28. 2002
    ..In particular Rpn11, a lid subunit, serves as the paradigm for MPN-containing proteins as it is highly conserved and important for proteasome function...
  3. ncbi request reprint Getting in and out of the proteasome
    M H Glickman
    Department of Biology, The Technion Israel Institute of Technology, Haifa
    Semin Cell Dev Biol 11:149-58. 2000
    ..This review will focus on the different proteasome functions, and how these are used in the multiple regulatory roles the proteasome plays in eukaryotic cells...
  4. pmc The proteasome and the delicate balance between destruction and rescue
    Michael H Glickman
    Department of Biology, Technion Israel Institute of Technology in Haifa, Israel
    PLoS Biol 2:E13. 2004
  5. ncbi request reprint The COP9 signalosome-like complex in S. cerevisiae and links to other PCI complexes
    Vered Maytal-Kivity
    Department of Biology and Institute for Catalysis Science and Technology ICST, Technion Israel Institute of Technology, 32000, Haifa, Israel
    Int J Biochem Cell Biol 35:706-15. 2003
    ..Pci8/Csn11 has previously been shown to interact with eIF3. Together, these results point to a network of interactions between these three structurally similar, yet functionally diverse, complexes...
  6. ncbi request reprint Keepers at the final gates: regulatory complexes and gating of the proteasome channel
    M Bajorek
    Department of Biology and the Institute for Catalysis Science and Technology, Technion Israel Institute of Technology, Haifa, Israel
    Cell Mol Life Sci 61:1579-88. 2004
    ..In this review, we will discuss the mechanisms proposed for channel gating and the interactions required to maintain stable closed and open conformations...
  7. ncbi request reprint Regulating the 26S proteasome
    M H Glickman
    Department of Biology, The Technion, Israel Institute of Technology, 32000 Haifa, Israel
    Curr Top Microbiol Immunol 268:43-72. 2002
    ..It is not be surprising that the proteasome plays diverse roles, and that its specific functions can be fine-tuned depending on biological context or need...
  8. pmc Extraproteasomal Rpn10 restricts access of the polyubiquitin-binding protein Dsk2 to proteasome
    Yulia Matiuhin
    Department of Biology, Technion Israel Institute of Technology, Haifa 32000, Israel
    Mol Cell 32:415-25. 2008
    ..This work highlights the importance of polyubiquitin shuttles such as Rpn10 and Dsk2 in controlling the ubiquitin landscape...
  9. ncbi request reprint Proteasome disassembly and downregulation is correlated with viability during stationary phase
    Monika Bajorek
    Department of Biology, The Technion Israel Institute of Technology, 32000 Haifa, Israel
    Curr Biol 13:1140-4. 2003
    ..Maintaining high viability during SP is essential for evolutionary fitness, which may explain the extreme conservation of channel gating residues in eukaryotic proteasomes...
  10. pmc The central unit within the 19S regulatory particle of the proteasome
    Rina Rosenzweig
    Department of Biology, Technion Israel Institute of Technology, 32000 Haifa, Israel
    Nat Struct Mol Biol 15:573-80. 2008
    ..Similar pairing of units is found in unfoldases and nuclear transporters, exposing common features of these protein nanomachines...
  11. doi request reprint PCI complexes: Beyond the proteasome, CSN, and eIF3 Troika
    Elah Pick
    Department of Biology, Haifa University at Oranim, Tivon, Israel
    Mol Cell 35:260-4. 2009
    ..The breadth of functions associated with the extended PCI family is a factor of shared subunits, among them a common factor Sem1/DSS1 that facilitates complex assembly...
  12. ncbi request reprint Proteasome plasticity
    Michael H Glickman
    Department of Biology, Technion Israel Institute of Technology, Haifa 32000, Israel
    FEBS Lett 579:3214-23. 2005
    ..Fascinating cross talk even occurs with ribosomes through common maturation factors. The dynamics of proteasome configurations and how they relate to diverse activities is the topic of this review...
  13. doi request reprint Chaperone-driven proteasome assembly
    Rina Rosenzweig
    Department of Biology, Technion Israel Institute of Technology, 32000 Haifa, Israel
    Biochem Soc Trans 36:807-12. 2008
    ..Both general and dedicated proteasome assembly chaperones regulate the efficiency and outcome of critical steps in proteasome biogenesis, and in complex association...
  14. pmc Participation of the proteasomal lid subunit Rpn11 in mitochondrial morphology and function is mapped to a distinct C-terminal domain
    Teresa Rinaldi
    Pasteur Institute Cenci Bolognetti Foundation and the Department of Cell and Developmental Biology, University of Rome I, 00185 Rome, Italy
    Biochem J 381:275-85. 2004
    ..Together, these results point to a unique role for the C-terminal region of Rpn11 in mitochondrial maintenance that may be independent of its role in proteasome-associated deubiquitination...
  15. ncbi request reprint Complementary roles for Rpn11 and Ubp6 in deubiquitination and proteolysis by the proteasome
    Adi Guterman
    Department of Biology and the Institute for Catalysis Science and Technology, The Technion, 32000 Haifa, Israel
    J Biol Chem 279:1729-38. 2004
    ..The fascinating observation that a single ubiquitin moiety is sufficient for targeting an otherwise stable substrate to proteasomes exposes how rapid deubiquitination of poorly ubiquitinated substrates may counteract degradation...
  16. ncbi request reprint Deubiquitinating enzymes are IN/(trinsic to proteasome function)
    Adi Guterman
    Department of Biology and the Institute for Catalysis Science and Technology, Technion Israel Institute of Technology, Haifa
    Curr Protein Pept Sci 5:201-11. 2004
    ..We hypothesize that polvubiquitin chains could also serve as "timers": by slowing down chain disassembly, longer chains allow ample time for unfolding and proteolysis of the substrate...
  17. pmc Dissection of the carboxyl-terminal domain of the proteasomal subunit Rpn11 in maintenance of mitochondrial structure and function
    Teresa Rinaldi
    Pasteur Institute Cenci Bolognetti Foundation, Department of Cell and Developmental Biology, University of Rome La Sapienza, 00185 Rome, Italy
    Mol Biol Cell 19:1022-31. 2008
    ..Finally, we investigate the mechanisms by which Rpn11 controls the mitochondrial shape and show that Rpn11 may regulate the mitochondrial fission and tubulation processes...
  18. ncbi request reprint A window of opportunity: timing protein degradation by trimming of sugars and ubiquitins
    Gerardo Z Lederkremer
    Department of Cell Research and Immunology, George Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv 69978, Israel
    Trends Biochem Sci 30:297-303. 2005
    ..Although these processes are compartmentalized to either side of the endoplasmic reticulum (ER) membrane, some proteins are sequentially subjected to both because they transverse this membrane for ER-associated degradation...
  19. ncbi request reprint Purification of proteasomes, proteasome subcomplexes, and proteasome-associated proteins from budding yeast
    David S Leggett
    ArQule Biomedical Institute, ArQule Inc, Norwood, MA, USA
    Methods Mol Biol 301:57-70. 2005
    ..When coupled with the genetic methods available in yeast, these biochemical procedures allow for detailed functional analysis of this unique protein complex...
  20. pmc COP9 signalosome components play a role in the mating pheromone response of S. cerevisiae
    Vered Maytal-Kivity
    Department of Biology and Institute for Catalysis Science and Technology, Technion Israel Institute of Technology, 32000 Haifa, Israel
    EMBO Rep 3:1215-21. 2002
    ..Csi1, a novel CSN interactor, exhibits opposite phenotypes. Deletants also accumulate Cdc53/cullin in a Rub1-modified form; however, this role of the CSN appears to be distinct from that in the mating pathway...
  21. doi request reprint Forging a proteasome alpha-ring with dedicated proteasome chaperones
    Rina Rosenzweig
    Nat Struct Mol Biol 15:218-20. 2008