Affiliation: Technion-Israel Institute of Technology
Glickman M, Ciechanover A. The ubiquitin-proteasome proteolytic pathway: destruction for the sake of construction. Physiol Rev. 2002;82:373-428 pubmed
..Among these are the modes of specific and timed recognition for the degradation of the many substrates and the mechanisms that underlie aberrations in the system that lead to pathogenesis of diseases. ..
Mansour W, Nakasone M, von DelbrÃ¼ck M, Yu Z, Krutauz D, Reis N, et al. Disassembly of Lys11 and mixed linkage polyubiquitin conjugates provides insights into function of proteasomal deubiquitinases Rpn11 and Ubp6. J Biol Chem. 2015;290:4688-704 pubmed publisher
..The reduced ability to disassemble homogeneous Lys(48)-linked chains longer than 4 Ub units may prolong residency time on the proteasome. ..
Yu Z, Livnat Levanon N, Kleifeld O, Mansour W, Nakasone M, Castaneda C, et al. Base-CP proteasome can serve as a platform for stepwise lid formation. Biosci Rep. 2015;35: pubmed publisher
Chojnacki M, Mansour W, Hameed D, Singh R, El Oualid F, Rosenzweig R, et al. Polyubiquitin-Photoactivatable Crosslinking Reagents for Mapping Ubiquitin Interactome Identify Rpn1 as a Proteasome Ubiquitin-Associating Subunit. Cell Chem Biol. 2017;24:443-457.e6 pubmed publisher
..Our work demonstrates the value of UbPT, and we expect that its future uses will help define and investigate the ubiquitin interactome. ..