Bianca Fuhrman

Summary

Affiliation: Technion-Israel Institute of Technology
Country: Israel

Publications

  1. ncbi request reprint Anti-atherogenicity of nutritional antioxidants
    B Fuhrman
    The Lipid Research Laboratory, Rambam Medical Center, Haifa, Israel
    IDrugs 4:82-92. 2001
  2. pmc Regulation of hepatic paraoxonase-1 expression
    Bianca Fuhrman
    The Lipid Research Laboratory, The Ruth and Bruce Rappaport Faculty of Medicine, Technion Israel Institute of Technology and Rambam Medical Center, 31096 Haifa, Israel
    J Lipids 2012:684010. 2012
  3. doi request reprint Urokinase plasminogen activator upregulates paraoxonase 2 expression in macrophages via an NADPH oxidase-dependent mechanism
    Bianca Fuhrman
    Lipid Research Laboratory, Rambam Medical Center, Haifa, Israel
    Arterioscler Thromb Vasc Biol 28:1361-7. 2008
  4. ncbi request reprint Urokinase plasminogen activator (uPA) stimulates cholesterol biosynthesis in macrophages through activation of SREBP-1 in a PI3-kinase and MEK-dependent manner
    Bianca Fuhrman
    The Lipid Research Laboratory, Technion Faculty of Medicine, The Rappaport Family Institute for Research in the Medical Sciences, and Rambam Medical Center, Haifa 31096, Israel
    Atherosclerosis 195:e108-16. 2007
  5. ncbi request reprint Ox-LDL induces monocyte-to-macrophage differentiation in vivo: Possible role for the macrophage colony stimulating factor receptor (M-CSF-R)
    Bianca Fuhrman
    The Lipid Research Laboratory, Technion Faculty of Medicine, The Rappaport Family Institute for Research in the Medical Sciences and Rambam Medical Center, Haifa 31096, Israel
    Atherosclerosis 196:598-607. 2008
  6. doi request reprint Pomegranate juice polyphenols increase recombinant paraoxonase-1 binding to high-density lipoprotein: studies in vitro and in diabetic patients
    Bianca Fuhrman
    Rambam Medical Center, Rappaport Family Institute for Research in Medical Sciences and Technion Faculty of Medicine, Haifa, Israel
    Nutrition 26:359-66. 2010
  7. doi request reprint Paraoxonase 1 (PON1) deficiency in mice is associated with reduced expression of macrophage SR-BI and consequently the loss of HDL cytoprotection against apoptosis
    Bianca Fuhrman
    The Lipid Research Laboratory, Technion Faculty of Medicine, The Rappaport Family Institute for Research in the Medical Sciences, and Rambam Medical Center, 31096 Haifa, Israel
    Atherosclerosis 211:61-8. 2010
  8. ncbi request reprint Grape powder polyphenols attenuate atherosclerosis development in apolipoprotein E deficient (E0) mice and reduce macrophage atherogenicity
    Bianca Fuhrman
    Lipid Research Laboratory and Department of Anatomy and Cell Biology, Technion Faculty of Medicine, Rappaport Family Institute for Research in the Medical Sciences and Rambam Medical Center, Haifa, Israel
    J Nutr 135:722-8. 2005
  9. doi request reprint Urokinase activates macrophage PON2 gene transcription via the PI3K/ROS/MEK/SREBP-2 signalling cascade mediated by the PDGFR-beta
    Bianca Fuhrman
    The Lipid Research Laboratory, Technion Faculty of Medicine, The Rappaport Family Institute for Research in the Medical Sciences, Rambam Medical Center, Haifa 31096, Israel
    Cardiovasc Res 84:145-54. 2009
  10. ncbi request reprint Preservation of paraoxonase activity by wine flavonoids: possible role in protection of LDL from lipid peroxidation
    Bianca Fuhrman
    Lipid Research Laboratory, Technion Faculty of Medicine, The Rappaport Family Institute for Research in the Medical Sciences, and Rambam Medical Center, Haifa, Israel
    Ann N Y Acad Sci 957:321-4. 2002

Collaborators

Detail Information

Publications36

  1. ncbi request reprint Anti-atherogenicity of nutritional antioxidants
    B Fuhrman
    The Lipid Research Laboratory, Rambam Medical Center, Haifa, Israel
    IDrugs 4:82-92. 2001
    ..This review reports on the recent data of the anti-atherosclerotic effects and mechanistical aspects of three major groups of dietary antioxidants: vitamin E, carotenoids and flavonoids...
  2. pmc Regulation of hepatic paraoxonase-1 expression
    Bianca Fuhrman
    The Lipid Research Laboratory, The Ruth and Bruce Rappaport Faculty of Medicine, Technion Israel Institute of Technology and Rambam Medical Center, 31096 Haifa, Israel
    J Lipids 2012:684010. 2012
    ..This paper summarizes recent progress in understanding the regulation of PON1 expression in hepatocytes...
  3. doi request reprint Urokinase plasminogen activator upregulates paraoxonase 2 expression in macrophages via an NADPH oxidase-dependent mechanism
    Bianca Fuhrman
    Lipid Research Laboratory, Rambam Medical Center, Haifa, Israel
    Arterioscler Thromb Vasc Biol 28:1361-7. 2008
    ..Increased macrophage oxidative stress in turn was shown to enhance PON2 expression. In the present study we investigated the effect of uPA on macrophage PON2 expression in relation to cellular oxidative stress...
  4. ncbi request reprint Urokinase plasminogen activator (uPA) stimulates cholesterol biosynthesis in macrophages through activation of SREBP-1 in a PI3-kinase and MEK-dependent manner
    Bianca Fuhrman
    The Lipid Research Laboratory, Technion Faculty of Medicine, The Rappaport Family Institute for Research in the Medical Sciences, and Rambam Medical Center, Haifa 31096, Israel
    Atherosclerosis 195:e108-16. 2007
    ..These findings provide new insight into the atherogenicity of uPA and may suggest new novel therapeutic means...
  5. ncbi request reprint Ox-LDL induces monocyte-to-macrophage differentiation in vivo: Possible role for the macrophage colony stimulating factor receptor (M-CSF-R)
    Bianca Fuhrman
    The Lipid Research Laboratory, Technion Faculty of Medicine, The Rappaport Family Institute for Research in the Medical Sciences and Rambam Medical Center, Haifa 31096, Israel
    Atherosclerosis 196:598-607. 2008
    ..We thus conclude that Ox-LDL induces monocyte differentiation to macrophages in vivo and this phenomenon involves activation of the M-CSF-receptor...
  6. doi request reprint Pomegranate juice polyphenols increase recombinant paraoxonase-1 binding to high-density lipoprotein: studies in vitro and in diabetic patients
    Bianca Fuhrman
    Rambam Medical Center, Rappaport Family Institute for Research in Medical Sciences and Technion Faculty of Medicine, Haifa, Israel
    Nutrition 26:359-66. 2010
    ....
  7. doi request reprint Paraoxonase 1 (PON1) deficiency in mice is associated with reduced expression of macrophage SR-BI and consequently the loss of HDL cytoprotection against apoptosis
    Bianca Fuhrman
    The Lipid Research Laboratory, Technion Faculty of Medicine, The Rappaport Family Institute for Research in the Medical Sciences, and Rambam Medical Center, 31096 Haifa, Israel
    Atherosclerosis 211:61-8. 2010
    ..Paraoxonase 1 (PON1) was shown to stimulate HDL binding and HDL-mediated cholesterol efflux from macrophages. This study examined the role of PON1 in the expression of proteins that enhance macrophage HDL binding, i.e. ABCA1 and SR-BI...
  8. ncbi request reprint Grape powder polyphenols attenuate atherosclerosis development in apolipoprotein E deficient (E0) mice and reduce macrophage atherogenicity
    Bianca Fuhrman
    Lipid Research Laboratory and Department of Anatomy and Cell Biology, Technion Faculty of Medicine, Rappaport Family Institute for Research in the Medical Sciences and Rambam Medical Center, Haifa, Israel
    J Nutr 135:722-8. 2005
    ..Both of these processes can eventually reduce macrophage cholesterol accumulation and foam cell formation and hence attenuate atherosclerosis development...
  9. doi request reprint Urokinase activates macrophage PON2 gene transcription via the PI3K/ROS/MEK/SREBP-2 signalling cascade mediated by the PDGFR-beta
    Bianca Fuhrman
    The Lipid Research Laboratory, Technion Faculty of Medicine, The Rappaport Family Institute for Research in the Medical Sciences, Rambam Medical Center, Haifa 31096, Israel
    Cardiovasc Res 84:145-54. 2009
    ..Here, we investigated the signalling pathway that leads to the expression of PON2 in macrophages in response to uPA...
  10. ncbi request reprint Preservation of paraoxonase activity by wine flavonoids: possible role in protection of LDL from lipid peroxidation
    Bianca Fuhrman
    Lipid Research Laboratory, Technion Faculty of Medicine, The Rappaport Family Institute for Research in the Medical Sciences, and Rambam Medical Center, Haifa, Israel
    Ann N Y Acad Sci 957:321-4. 2002
    ....
  11. ncbi request reprint Atorvastatin therapy in hypercholesterolemic patients suppresses cellular uptake of oxidized-LDL by differentiating monocytes
    Bianca Fuhrman
    The Lipid Research Laboratory, Technion Faculty of Medicine, The Rappaport Family Institute for Research in the Medical Sciences and Rambam Medical Center, 31096, Haifa, Israel
    Atherosclerosis 164:179-85. 2002
    ..These effects may account for the attenuation of atherogenesis in hypercholesterolemic patients following atorvastatin treatment...
  12. doi request reprint The urokinase system in the pathogenesis of atherosclerosis
    Bianca Fuhrman
    The Lipid Research Laboratory, Technion Faculty of Medicine, Rambam Medical Center, Haifa 31096, Israel
    Atherosclerosis 222:8-14. 2012
    ..An imbalance in the uPA/uPAR system leads to dis-orders in tissue structure and function. This review summarizes recent progress in understanding the role and mechanisms of the uPA/uPAR system in atherogenesis...
  13. ncbi request reprint Cell-induced copper ion-mediated low density lipoprotein oxidation increases during in vivo monocyte-to-macrophage differentiation
    Bianca Fuhrman
    Lipid Research Laboratory, Technion Faculty of Medicine, The Rappaport Family Institute for Research in the Medical Sciences and Rambam Medical Center, Haifa, Israel 31096
    Free Radic Biol Med 37:259-71. 2004
    ....
  14. ncbi request reprint Paraoxonase 2 (PON2) expression is upregulated via a reduced-nicotinamide-adenine-dinucleotide-phosphate (NADPH)-oxidase-dependent mechanism during monocytes differentiation into macrophages
    Maayan Shiner
    Lipid Research Laboratory, Technion Faculty of Medicine, The Rappaport Family Institute for Research in the Medical Sciences and Rambam Medical Center, Haifa 31096, Israel
    Free Radic Biol Med 37:2052-63. 2004
    ..PON2 stimulation may represent a compensatory mechanism against the increase in cellular superoxide anion production and atherogenesis...
  15. ncbi request reprint Macrophage paraoxonase 2 (PON2) expression is up-regulated by pomegranate juice phenolic anti-oxidants via PPAR gamma and AP-1 pathway activation
    Maayan Shiner
    Lipid Research Laboratory, Technion Faculty of Medicine, The Rappaport Family Institute for Research in the Medical Sciences and Rambam Medical Center, Haifa 31096, Israel
    Atherosclerosis 195:313-21. 2007
    ....
  16. ncbi request reprint Oxidative stress increases the expression of the CD36 scavenger receptor and the cellular uptake of oxidized low-density lipoprotein in macrophages from atherosclerotic mice: protective role of antioxidants and of paraoxonase
    Bianca Fuhrman
    The Lipid Research Laboratory, Technion Faculty of Medicine, The Rappaport Family Institute for Research in the Medical Sciences and Rambam Medical Center, Haifa 31096, Israel
    Atherosclerosis 161:307-16. 2002
    ..In conclusion, our results are the first to demonstrate that macrophage lipid peroxidation stimulates CD36 mRNA expression and enhances the cellular uptake of Ox-LDL...
  17. ncbi request reprint Pomegranate juice inhibits oxidized LDL uptake and cholesterol biosynthesis in macrophages
    Bianca Fuhrman
    Lipid Research Laboratory, Technion Faculty of Medicine, The Rappaport Family Institute for Research in the Medical Sciences, Rambam Medical Center, Haifa 31096, Israel
    J Nutr Biochem 16:570-6. 2005
    ..We conclude that PJ-mediated suppression of Ox-LDL degradation and of cholesterol biosynthesis in macrophages can lead to reduced cellular cholesterol accumulation and foam cell formation...
  18. ncbi request reprint Macrophage paraoxonase 2 (PON2) expression is upregulated by unesterified cholesterol through activation of the phosphatidylinositol 3-kinase (PI3K) pathway
    Maayan Shiner
    Lipid Research Laboratory, Technion Faculty of Medicine, The Rappaport Family Institute for Research in the Medical Sciences and Rambam Medical Center, Haifa 31096, Israel
    Biol Chem 388:1353-8. 2007
    ..Thus, we conclude from our data that macrophage PON2 expression is upregulated in UC-enriched macrophages through activation of the PI(3)K signal pathway...
  19. doi request reprint Paraoxonase 1 (PON1) expression in hepatocytes is upregulated by pomegranate polyphenols: a role for PPAR-gamma pathway
    Jasmin Khateeb
    The Lipid Research Laboratory, Technion Faculty of Medicine, The Rappaport Family Institute for Research in the Medical Sciences, and Rambam Medical Center, Haifa, Israel
    Atherosclerosis 208:119-25. 2010
    ..Because promoter sequence of PON1 gene indicates that it could be regulated by nuclear receptors, we investigated the effect of PJ polyphenols on PON1 gene expression in HuH7 hepatocytes...
  20. ncbi request reprint Antiatherosclerotic effects of licorice extract supplementation on hypercholesterolemic patients: increased resistance of LDL to atherogenic modifications, reduced plasma lipid levels, and decreased systolic blood pressure
    Bianca Fuhrman
    Lipid Research Laboratory, Technion Faculty of Medicine, The Rappaport Family Institute for Research in the Medical Sciences and Rambam Medical Center, Haifa, Israel
    Nutrition 18:268-73. 2002
    ..In the present study, we extended our investigation to analyze the antiatherogenic effects of licorice-root extract consumption in moderately hypercholesterolemic patients...
  21. ncbi request reprint Consumption of pomegranate decreases serum oxidative stress and reduces disease activity in patients with active rheumatoid arthritis: a pilot study
    Alexandra Balbir-Gurman
    Rheumatology Unit, Rambam Health Care Campus, Haifa, Israel
    Isr Med Assoc J 13:474-9. 2011
    ..Pomegranate extract (POMx) consumption has been shown to reduce the incidence and severity of collagen-induced arthritis in mice...
  22. doi request reprint Paraoxonase 1 (PON1) reduces macrophage inflammatory responses
    Saar Aharoni
    The Lipid Research Laboratory, Technion Faculty of Medicine, The Rappaport Family Institute for Research in the Medical Sciences, and Rambam Medical Center, Haifa 31096, Israel
    Atherosclerosis 228:353-61. 2013
    ..Paraoxonase 1 (PON1) was suggested to play an anti-inflammatory role. In the present study we questioned whether PON1 has a direct impact on macrophage inflammatory responses, and the possible functional implications of such effects...
  23. ncbi request reprint Wine flavonoids protect against LDL oxidation and atherosclerosis
    Michael Aviram
    The Lipid Research Laboratory, Technion Faculty of Medicine, The Rappaport Family Institute for Research in the Medical Sciences and Rambam Medical Center, Haifa, Israel
    Ann N Y Acad Sci 957:146-61. 2002
    ....
  24. ncbi request reprint Acetylcholine esterase protects LDL against oxidation
    Bianca Fuhrman
    The Lipid Research Laboratory, Technion Faculty of Medicine, The Rappaport Family Institute for Research in the Medical Sciences and Rambam Medical Center, Haifa, Israel
    Biochem Biophys Res Commun 322:974-8. 2004
    ..We conclude that AChE, similar to PON1, can hydrolyze lipid peroxides and thus may prevent the accumulation of oxidized LDL and attenuate atherosclerosis development...
  25. doi request reprint Urokinase-type plasminogen activator downregulates paraoxonase 1 expression in hepatocytes by stimulating peroxisome proliferator-activated receptor-γ nuclear export
    Jasmin Khateeb
    Lipid Research Laboratory, Rambam Medical Center, Haifa, Israel, 31096
    Arterioscler Thromb Vasc Biol 32:449-58. 2012
    ..Because the liver is the main site for PON1 production, in the present study, we tested whether uPA influences PON1 expression in hepatocytes...
  26. doi request reprint Amphiphilic/Bipolar metallocorroles that catalyze the decomposition of reactive oxygen and nitrogen species, rescue lipoproteins from oxidative damage, and attenuate atherosclerosis in mice
    Adi Haber
    Schulich Faculty of Chemistry, Technion Israel Institute of Technology, Technion City, Haifa, Israel
    Angew Chem Int Ed Engl 47:7896-900. 2008
  27. doi request reprint High glucose stimulates macrophage SR-BI expression and induces a switch in its activity from cholesterol efflux to cholesterol influx
    Anna Gantman
    The Lipid Research Laboratory, Technion Faculty of Medicine, The Rappaport Family Institute for Research in the Medical Sciences, and Rambam Medical Center, Haifa, Israel
    Biochem Biophys Res Commun 391:523-8. 2010
    ..This study examined the expression of proteins involved in cholesterol transport, i.e. ABCA1 and SR-BI, under diabetic conditions...
  28. ncbi request reprint A biphasic U-shape effect of cellular oxidative stress on the macrophage anti-oxidant paraoxonase 2 (PON2) enzymatic activity
    Maayan Shiner
    Lipid Research Laboratory, Technion Faculty of Medicine, The Rappaport Family Institute for Research in the Medical Sciences and Rambam Medical Center, Haifa 31096, Israel
    Biochem Biophys Res Commun 349:1094-9. 2006
    ....
  29. ncbi request reprint Paraoxonase 1 (PON1) is present in postprandial chylomicrons
    Bianca Fuhrman
    The Lipid Research Laboratory, Technion Faculty of Medicine, The Rappaport Family Institute for Research in the Medical Sciences and Rambam Medical Center, Haifa 31096, Israel
    Atherosclerosis 180:55-61. 2005
    ..We conclude that postprandial chylomicrons contain PON1, which may function in the removal of atherogenic oxidized lipids...
  30. doi request reprint Urokinase-type plasminogen activator (uPA) stimulates triglyceride synthesis in Huh7 hepatoma cells via p38-dependent upregulation of DGAT2
    Nicole Paland
    The Lipid Research Laboratory, Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    Atherosclerosis 237:200-7. 2014
    ..In this study we questioned whether uPA modulates triglyceride metabolism in the liver, and investigated the mechanisms involved in the observed processes...
  31. doi request reprint Urokinase-type plasminogen activator (uPA) modulates monocyte-to-macrophage differentiation and prevents Ox-LDL-induced macrophage apoptosis
    Nicole Paland
    The Lipid Research Laboratory, Technion Faculty of Medicine, Rambam Medical Center, Haifa 31096, Israel
    Atherosclerosis 231:29-38. 2013
    ..In the present study we investigated the effect and mechanisms of action of uPA on monocyte-to-macrophage differentiation and on macrophage apoptotic death...
  32. ncbi request reprint Consumption of a novel dietary formula of plant sterol esters of canola oil fatty acids, in a canola oil matrix containing 1,3-diacylglycerol, reduces oxidative stress in atherosclerotic apolipoprotein E-deficient mice
    Bianca Fuhrman
    The Lipid Research Laboratory, Technion Faculty of Medicine and Rambam Medical Center, 31096 Haifa, Israel
    J Agric Food Chem 55:2028-33. 2007
    ..These findings indicate that PS-CO supplementation is beneficial in reducing serum lipid levels, and serum and macrophage oxidative stress, thus contributing to the reduction in atherogenic risk factors...
  33. ncbi request reprint Aspirin promotes low density lipoprotein susceptibility to oxidative modification in healthy volunteers
    Matti Waterman
    Department of Internal Medicine A, Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    Isr Med Assoc J 11:730-4. 2009
    ..However, the effect of the more common lower dose aspirin on LDL oxidation is not known...
  34. doi request reprint Urokinase-type plasminogen activator (uPA) decreases hepatic SR-BI expression and impairs HDL-mediated reverse cholesterol transport
    Semyon Chulsky
    The Lipid Research Laboratory, Technion Faculty of Medicine, The Rappaport Family Institute for Research in the Medical Sciences, and Rambam Medical Center, Haifa 31096, Israel
    Atherosclerosis 233:11-8. 2014
    ....
  35. doi request reprint Pomegranate juice polyphenols induce a phenotypic switch in macrophage polarization favoring a M2 anti-inflammatory state
    Saar Aharoni
    The Lipid Research Laboratory, Technion Faculty of Medicine, The Rappaport Family Institute for Research in the Medical Sciences, and Rambam Medical Center, Haifa, Israel
    Biofactors 41:44-51. 2015
    ....
  36. ncbi request reprint High plasma high-density lipoprotein levels, very low cardiovascular risk profile, and subclinical carotid atherosclerosis in postmenopausal women
    Shlomo Keidar
    The Lipid Research Laboratory, The Rappaport Faculty of Medicine, Technion The Rappaport Family Institute for Research in the Medical Sciences and Rambam Medical Center, Haifa, Israel Internal Medicine Department A, Rambam Medical Center, Haifa 31096, Israel
    J Clin Lipidol 3:345-50. 2009
    ..Low plasma concentrations of high-density lipoprotein (HDL) are associated with increased risk of cardiovascular disease. However, recently several studies have questioned the protective role of high plasma HDL levels...