Edna Efrati

Summary

Affiliation: Technion-Israel Institute of Technology
Country: Israel

Publications

  1. doi request reprint Distribution of TPMT risk alleles for thiopurine [correction of thioupurine] toxicity in the Israeli population
    Edna Efrati
    Center for Translational Genetics, B Rappaport Institute for Research in the Medical Sciences, Faculty of Medicine, Technion Israel Institute of Technology and Rambam Health Care Campus, Haifa, Israel
    Eur J Clin Pharmacol 65:257-62. 2009
  2. ncbi request reprint Distribution of CYP2C9 and VKORC1 risk alleles for warfarin sensitivity and resistance in the Israeli population
    Edna Efrati
    Center for Translational Genetics, B Rappaport Institute for Research in Medical Sciences, Faculty of Medicine, Technion Israel Institute of Technology and Rambam Health Care Campus, Haifa, Israel
    Curr Drug Saf 5:190-3. 2010
  3. ncbi request reprint Risk factors for serious adverse effects of thiopurines in patients with Crohn's disease
    Yoav Mazor
    Gastroenterology Department, Rambam Health Care Campus, Haifa, Israel
    Curr Drug Saf 8:181-5. 2013
  4. doi request reprint Thiopurine effectiveness in patients with Crohn's disease: a study of genetic and clinical predictive factors
    Eduard Koifman
    Department of Gastroenterology, Rambam Health Care Campus, Haifa, Israel
    Inflamm Bowel Dis 19:1639-44. 2013
  5. doi request reprint Population distribution of methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C risk alleles for methotrexate toxicity in Israel
    Edna Efrati
    Center for Translational Genetics, B Rappaport Institute for Research in the Medical Sciences, Faculty of Medicine, Technion Israel Institute of Technology and Rambam Health Care Campus, Haifa, Israel
    Rheumatol Int 33:1001-4. 2013
  6. doi request reprint Non-Jewish Israeli IBD patients have significantly higher glutathione S-transferase GSTT1-null frequency
    Amir Karban
    Internal Medicine C, Rambam Health Care Campus, P O Box 9602, Haifa, 31096, Israel
    Dig Dis Sci 56:2081-7. 2011
  7. pmc Pendrin, a novel transcriptional target of the uroguanylin system
    Julia Rozenfeld
    Laboratory of Developmental Nephrology, Department of Physiology and Biophysics, Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    Cell Physiol Biochem 32:221-37. 2013
  8. pmc The pendrin anion exchanger gene is transcriptionally regulated by uroguanylin: a novel enterorenal link
    Julia Rozenfeld
    Laboratory of Developmental Nephrology, Department of Physiology and Biophysics, Haifa, Israel
    Am J Physiol Renal Physiol 302:F614-24. 2012
  9. ncbi request reprint Pharmacokinetic and pharmacogenetic analysis of oral busulfan in stem cell transplantation: prediction of poor drug metabolism to prevent drug toxicity
    Norberto Krivoy
    Rappaport Rambam Center for Translational Genetics, Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    Curr Drug Saf 7:211-7. 2012
  10. ncbi request reprint Autosomal recessive renal proximal tubulopathy and hypercalciuria: a new syndrome
    Daniella Magen
    Pediatric Nephrology Unit, Meyer Children s Hospital, Rambam Medical Center and Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    Am J Kidney Dis 43:600-6. 2004

Collaborators

Detail Information

Publications13

  1. doi request reprint Distribution of TPMT risk alleles for thiopurine [correction of thioupurine] toxicity in the Israeli population
    Edna Efrati
    Center for Translational Genetics, B Rappaport Institute for Research in the Medical Sciences, Faculty of Medicine, Technion Israel Institute of Technology and Rambam Health Care Campus, Haifa, Israel
    Eur J Clin Pharmacol 65:257-62. 2009
    ..The purpose of this study was to determine the frequency and distribution of TPMT polymorphic variants, known to functionally impair TPMT activity, in the highly heterogeneous Israeli population...
  2. ncbi request reprint Distribution of CYP2C9 and VKORC1 risk alleles for warfarin sensitivity and resistance in the Israeli population
    Edna Efrati
    Center for Translational Genetics, B Rappaport Institute for Research in Medical Sciences, Faculty of Medicine, Technion Israel Institute of Technology and Rambam Health Care Campus, Haifa, Israel
    Curr Drug Saf 5:190-3. 2010
    ..This study was designed to delineate the relative frequency of CYP2C9 and VKORC1 polymorphisms known to affect warfarin response in the highly heterogeneous Israeli population...
  3. ncbi request reprint Risk factors for serious adverse effects of thiopurines in patients with Crohn's disease
    Yoav Mazor
    Gastroenterology Department, Rambam Health Care Campus, Haifa, Israel
    Curr Drug Saf 8:181-5. 2013
    ..e. myelosuppression, hepatotoxicity and pancreatitis) in patients with CD. Corroboration of these associations in larger cohorts is warranted. ..
  4. doi request reprint Thiopurine effectiveness in patients with Crohn's disease: a study of genetic and clinical predictive factors
    Eduard Koifman
    Department of Gastroenterology, Rambam Health Care Campus, Haifa, Israel
    Inflamm Bowel Dis 19:1639-44. 2013
    ..To assess whether polymorphisms in Rac1 and other apoptosis-related genes, combined with clinical parameters, can predict response to thiopurines...
  5. doi request reprint Population distribution of methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C risk alleles for methotrexate toxicity in Israel
    Edna Efrati
    Center for Translational Genetics, B Rappaport Institute for Research in the Medical Sciences, Faculty of Medicine, Technion Israel Institute of Technology and Rambam Health Care Campus, Haifa, Israel
    Rheumatol Int 33:1001-4. 2013
    ..01 for C677T, p < 0.05 for A1298C). These data underscore the importance of geographic genetic analysis for a better understanding of human pharmacotherapy and personalized medicine...
  6. doi request reprint Non-Jewish Israeli IBD patients have significantly higher glutathione S-transferase GSTT1-null frequency
    Amir Karban
    Internal Medicine C, Rambam Health Care Campus, P O Box 9602, Haifa, 31096, Israel
    Dig Dis Sci 56:2081-7. 2011
    ....
  7. pmc Pendrin, a novel transcriptional target of the uroguanylin system
    Julia Rozenfeld
    Laboratory of Developmental Nephrology, Department of Physiology and Biophysics, Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    Cell Physiol Biochem 32:221-37. 2013
    ....
  8. pmc The pendrin anion exchanger gene is transcriptionally regulated by uroguanylin: a novel enterorenal link
    Julia Rozenfeld
    Laboratory of Developmental Nephrology, Department of Physiology and Biophysics, Haifa, Israel
    Am J Physiol Renal Physiol 302:F614-24. 2012
    ..UGN exerts its inhibitory activity on the hPDS promoter likely via HSF1 action at a defined HSE site. These data define a novel signaling pathway involved in the enterorenal axis controlling electrolyte and water homeostasis...
  9. ncbi request reprint Pharmacokinetic and pharmacogenetic analysis of oral busulfan in stem cell transplantation: prediction of poor drug metabolism to prevent drug toxicity
    Norberto Krivoy
    Rappaport Rambam Center for Translational Genetics, Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    Curr Drug Saf 7:211-7. 2012
    ..In conclusion, GST and ABCB1 genotyping may assist care-givers in personalizing BU dosage with less trial-and-error and may enable preemptive identification of patients at risk for BU toxicity...
  10. ncbi request reprint Autosomal recessive renal proximal tubulopathy and hypercalciuria: a new syndrome
    Daniella Magen
    Pediatric Nephrology Unit, Meyer Children s Hospital, Rambam Medical Center and Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    Am J Kidney Dis 43:600-6. 2004
    ....
  11. doi request reprint Influence of glutathione S-transferase A1, P1, M1, T1 polymorphisms on oral busulfan pharmacokinetics in children with congenital hemoglobinopathies undergoing hematopoietic stem cell transplantation
    Ronit Elhasid
    Pediatric Hemato Oncology and Bone Marrow Transplant Department, Meyer Children s Hospital, Rambam Health Care Campus, Haifa, Israel
    Pediatr Blood Cancer 55:1172-9. 2010
    ....
  12. doi request reprint LNA-based PCR clamping enrichment assay for the identification of KRAS mutations
    Edna Efrati
    Center for Translational Genetics, B Rappaport Institute for Research in the Medical Sciences, Technion Israel Institute of Technology and Rambam Health Care Campus, Haifa, Israel
    Cancer Biomark 8:89-94. 2010
    ..In the present study, we developed a KRAS mutations detection method that is both simple and sensitive...
  13. pmc Transcriptional regulation of the pendrin gene
    Julia Rozenfeld
    Laboratory of Developmental Nephrology, Department of Physiology and Biophysics, Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    Cell Physiol Biochem 28:385-96. 2011
    ..The distinct response elements and the corresponding transcription factors mediating the effect of these modulators on the PDS promoter remain to be identified and characterized...