M Aviram

Summary

Affiliation: Technion-Israel Institute of Technology
Country: Israel

Publications

  1. ncbi request reprint Pomegranate juice consumption reduces oxidative stress, atherogenic modifications to LDL, and platelet aggregation: studies in humans and in atherosclerotic apolipoprotein E-deficient mice
    M Aviram
    Lipid Research Laboratory and the Division of Morphological Sciences, Technion Faculty of Medicine, The Rappaport Family Institute for Research in the Medical Sciences and Rambam Medical Center, Haifa, Israel
    Am J Clin Nutr 71:1062-76. 2000
  2. ncbi request reprint HDL--associated paraoxonase 1 (PON1) and dietary antioxidants attenuate lipoprotein oxidation, macrophage foam cells formation and atherosclerosis development
    Michael Aviram
    The Lipid Research Laboratory, Technion Faculty of Medicine, The Rappaport Family Institute for Research in the Medical Sciencesand Rambam Medical Center, Haifa, Israel
    Pathophysiol Haemost Thromb 35:146-51. 2006
  3. ncbi request reprint Macrophage foam cell formation during early atherogenesis is determined by the balance between pro-oxidants and anti-oxidants in arterial cells and blood lipoproteins
    M Aviram
    The Lipid Research Laboratory, Rambam Medical Center, The Bruce Rappaport Faculty of Medicine, Technion, Haifa, Israel
    Antioxid Redox Signal 1:585-94. 1999
  4. ncbi request reprint Does paraoxonase play a role in susceptibility to cardiovascular disease?
    M Aviram
    The Lipid Research Laboratory, Technion Faculty of Medicine, The Rappaport Family Institute for Research in the Medical Sciences, Haifa, Israel
    Mol Med Today 5:381-6. 1999
  5. ncbi request reprint Human serum paraoxonases (PON1) Q and R selectively decrease lipid peroxides in human coronary and carotid atherosclerotic lesions: PON1 esterase and peroxidase-like activities
    M Aviram
    Lipid Research Laboratory, Technion Faculty of Medicine, The Rappaport Family Institute for Research in the Medical Sciences, Rambam Medical Center, Haifa, Israel
    Circulation 101:2510-7. 2000
  6. ncbi request reprint Pomegranate juice flavonoids inhibit low-density lipoprotein oxidation and cardiovascular diseases: studies in atherosclerotic mice and in humans
    M Aviram
    Lipid Research Laboratory, Technion Faculty of Medicine, Rappaport Family Institute for Research in the Medical Sciences, Rambam Medical Center, Haifa, Israel, 31096
    Drugs Exp Clin Res 28:49-62. 2002
  7. ncbi request reprint Review of human studies on oxidative damage and antioxidant protection related to cardiovascular diseases
    M Aviram
    The Lipid Research Laboratory, Technion Faculty of Medicine, The Rappaport Family Institute for Research in the Medical Sciences and Rambam Medical Center, Haifa, Israel
    Free Radic Res 33:S85-97. 2000
  8. ncbi request reprint Introduction to the serial review on paraoxonases, oxidative stress, and cardiovascular diseases
    Michael Aviram
    The Lipid Research Laboratory, Ramban Medical Center, Technion Faculty of Medicine, 31096 Bat Galim, Haifa, Israel
    Free Radic Biol Med 37:1301-3. 2004
  9. ncbi request reprint Paraoxonases 1, 2, and 3, oxidative stress, and macrophage foam cell formation during atherosclerosis development
    Michael Aviram
    The Lipid Research Laboratory, Technion Faculty of Medicine, The Rappaport Family Institute for Research in the Medical Sciences and Rambam Medical Center, 31096 Haifa, Israel
    Free Radic Biol Med 37:1304-16. 2004
  10. ncbi request reprint Wine flavonoids protect against LDL oxidation and atherosclerosis
    Michael Aviram
    The Lipid Research Laboratory, Technion Faculty of Medicine, The Rappaport Family Institute for Research in the Medical Sciences and Rambam Medical Center, Haifa, Israel
    Ann N Y Acad Sci 957:146-61. 2002

Collaborators

Detail Information

Publications100

  1. ncbi request reprint Pomegranate juice consumption reduces oxidative stress, atherogenic modifications to LDL, and platelet aggregation: studies in humans and in atherosclerotic apolipoprotein E-deficient mice
    M Aviram
    Lipid Research Laboratory and the Division of Morphological Sciences, Technion Faculty of Medicine, The Rappaport Family Institute for Research in the Medical Sciences and Rambam Medical Center, Haifa, Israel
    Am J Clin Nutr 71:1062-76. 2000
    ..Pomegranates are a source of polyphenols and other antioxidants...
  2. ncbi request reprint HDL--associated paraoxonase 1 (PON1) and dietary antioxidants attenuate lipoprotein oxidation, macrophage foam cells formation and atherosclerosis development
    Michael Aviram
    The Lipid Research Laboratory, Technion Faculty of Medicine, The Rappaport Family Institute for Research in the Medical Sciencesand Rambam Medical Center, Haifa, Israel
    Pathophysiol Haemost Thromb 35:146-51. 2006
  3. ncbi request reprint Macrophage foam cell formation during early atherogenesis is determined by the balance between pro-oxidants and anti-oxidants in arterial cells and blood lipoproteins
    M Aviram
    The Lipid Research Laboratory, Rambam Medical Center, The Bruce Rappaport Faculty of Medicine, Technion, Haifa, Israel
    Antioxid Redox Signal 1:585-94. 1999
    ..Thus, the combination of antioxidants together with active paraoxonase decreases the formation of Ox-LDL and preserves PON1's ability to hydrolyze this atherogenic lipoprotein and hence, to attenuate atherosclerosis...
  4. ncbi request reprint Does paraoxonase play a role in susceptibility to cardiovascular disease?
    M Aviram
    The Lipid Research Laboratory, Technion Faculty of Medicine, The Rappaport Family Institute for Research in the Medical Sciences, Haifa, Israel
    Mol Med Today 5:381-6. 1999
    ..Interventions that preserve or enhance PON1 activity, as well as manipulations of PON1 polymorphisms, might help delay the onset of CHD...
  5. ncbi request reprint Human serum paraoxonases (PON1) Q and R selectively decrease lipid peroxides in human coronary and carotid atherosclerotic lesions: PON1 esterase and peroxidase-like activities
    M Aviram
    Lipid Research Laboratory, Technion Faculty of Medicine, The Rappaport Family Institute for Research in the Medical Sciences, Rambam Medical Center, Haifa, Israel
    Circulation 101:2510-7. 2000
    ..PON1 protects LDL from oxidation, and during LDL oxidation, PON1 is inactivated...
  6. ncbi request reprint Pomegranate juice flavonoids inhibit low-density lipoprotein oxidation and cardiovascular diseases: studies in atherosclerotic mice and in humans
    M Aviram
    Lipid Research Laboratory, Technion Faculty of Medicine, Rappaport Family Institute for Research in the Medical Sciences, Rambam Medical Center, Haifa, Israel, 31096
    Drugs Exp Clin Res 28:49-62. 2002
    ..Dietary supplementation of polyphenol-rich pomegranate juice to atherosclerotic mice significantly inhibited the development of atherosclerotic lesions and this may be attributed to the protection of LDL against oxidation...
  7. ncbi request reprint Review of human studies on oxidative damage and antioxidant protection related to cardiovascular diseases
    M Aviram
    The Lipid Research Laboratory, Technion Faculty of Medicine, The Rappaport Family Institute for Research in the Medical Sciences and Rambam Medical Center, Haifa, Israel
    Free Radic Res 33:S85-97. 2000
    ....
  8. ncbi request reprint Introduction to the serial review on paraoxonases, oxidative stress, and cardiovascular diseases
    Michael Aviram
    The Lipid Research Laboratory, Ramban Medical Center, Technion Faculty of Medicine, 31096 Bat Galim, Haifa, Israel
    Free Radic Biol Med 37:1301-3. 2004
  9. ncbi request reprint Paraoxonases 1, 2, and 3, oxidative stress, and macrophage foam cell formation during atherosclerosis development
    Michael Aviram
    The Lipid Research Laboratory, Technion Faculty of Medicine, The Rappaport Family Institute for Research in the Medical Sciences and Rambam Medical Center, 31096 Haifa, Israel
    Free Radic Biol Med 37:1304-16. 2004
    ..Intervention to increase the paraoxonases (cellular and humoral) by dietary or pharmacological means can reduce macrophage foam cell formation and attenuate atherosclerosis development...
  10. ncbi request reprint Wine flavonoids protect against LDL oxidation and atherosclerosis
    Michael Aviram
    The Lipid Research Laboratory, Technion Faculty of Medicine, The Rappaport Family Institute for Research in the Medical Sciences and Rambam Medical Center, Haifa, Israel
    Ann N Y Acad Sci 957:146-61. 2002
    ....
  11. ncbi request reprint Pomegranate juice consumption inhibits serum angiotensin converting enzyme activity and reduces systolic blood pressure
    M Aviram
    The Lipid Research Laboratory, Technion Faculty of Medicine, The Rappaport Family Institute for Research in the Medical Sciences, 31096 Haifa, Israel
    Atherosclerosis 158:195-8. 2001
    ....
  12. ncbi request reprint Paraoxonases and cardiovascular diseases: pharmacological and nutritional influences
    Michael Aviram
    The Lipid Research Laboratory, Technion Faculty of Medicine, The Rappaport Family Institute for Research in the Medical Sciences and Rambam Medical Center, Haifa, Israel
    Curr Opin Lipidol 16:393-9. 2005
    ..To summarize the new articles published in the last year on paraoxonases, including their expression in cardiovascular diseases, and regulation by pharmacological and nutritional means...
  13. ncbi request reprint Human serum paraoxonase (PON 1) is inactivated by oxidized low density lipoprotein and preserved by antioxidants
    M Aviram
    The Lipid Research Laboratory, Technion Faculty of Medicine, The Rappaport Family Institute for Research in the Medical Sciences and Rambam Medical Center, Haifa, Israel
    Free Radic Biol Med 26:892-904. 1999
    ..e. prevention of its formation, and removal of Ox-LDL associated oxidized lipids which are generated during LDL oxidation...
  14. ncbi request reprint Atorvastatin and gemfibrozil metabolites, but not the parent drugs, are potent antioxidants against lipoprotein oxidation
    M Aviram
    The Lipid Research Laboratory, Technion Faculty of Medicine, The Rappaport Family Institute for Research in the Medical Sciences and Rambam Medical Center, Haifa, Israel
    Atherosclerosis 138:271-80. 1998
    ..We hypothesize that in addition to their beneficial lipid regulating activity, specific metabolites of both drugs may also reduce the atherogenic potential of lipoproteins through their antioxidant properties...
  15. ncbi request reprint Pomegranate juice consumption for 3 years by patients with carotid artery stenosis reduces common carotid intima-media thickness, blood pressure and LDL oxidation
    Michael Aviram
    The Lipid Research Laboratory, Rappaport Family Institute for Research in the Medical Sciences, Rambam Medical Center, Haifa 31096, Israel
    Clin Nutr 23:423-33. 2004
    ..The results of the present study thus suggest that PJ consumption by patients with CAS decreases carotid IMT and systolic blood pressure and these effects could be related to the potent antioxidant characteristics of PJ polyphenols...
  16. ncbi request reprint Interaction of oxidized low density lipoprotein with macrophages in atherosclerosis, and the antiatherogenicity of antioxidants
    M Aviram
    Lipid Research Laboratory, Technion Faculty of Medicine, Rappaport Family Institute for Research, Haifa, Israel
    Eur J Clin Chem Clin Biochem 34:599-608. 1996
    ..This effect could be associated with a reduction in the size of the atherosclerotic lesion and may thus contribute to attenuation of the atherosclerotic process...
  17. ncbi request reprint Microsomal cytochromes P450 catalyze the oxidation of low density lipoprotein
    M Aviram
    The Lipid Research Laboratory, Technion Faculty of Medicine, The Rappaport Family Institute for Research in the Medical Sciences and Rambam Medical Center, Haifa, Israel
    Atherosclerosis 143:253-60. 1999
    ..We thus conclude that LDL can be oxidized by some cytochrome P450s and, as some of these enzymes are present in liver and in arterial wall, they may have a physio/pathological relevance to LDL oxidation and atherogenesis...
  18. ncbi request reprint Paraoxonase active site required for protection against LDL oxidation involves its free sulfhydryl group and is different from that required for its arylesterase/paraoxonase activities: selective action of human paraoxonase allozymes Q and R
    M Aviram
    Lipid Research Laboratory, Technion Faculty of Medicine, The Rappaport Family Institute for Research in the Medical Sciences and Rambam Medical Center, Haifa, Israel
    Arterioscler Thromb Vasc Biol 18:1617-24. 1998
    ....
  19. doi request reprint Pomegranate phenolics from the peels, arils, and flowers are antiatherogenic: studies in vivo in atherosclerotic apolipoprotein e-deficient (E 0) mice and in vitro in cultured macrophages and lipoproteins
    Michael Aviram
    The Lipid Research Laboratory, Rambam Medical Center, Haifa, Israel
    J Agric Food Chem 56:1148-57. 2008
    ..We conclude that attenuation of atherosclerosis development by some of the POM extracts and, in particular, POMf, could be related to the combined beneficial effects on serum lipids levels and on macrophage atherogenic properties...
  20. pmc Paraoxonase inhibits high-density lipoprotein oxidation and preserves its functions. A possible peroxidative role for paraoxonase
    M Aviram
    The Lipid Research Laboratory, Technion Faculty of Medicine, The Rappaport Family Institute for Research in the Medical Sciences and Rambam Medical Center, Haifa, Israel, 31096
    J Clin Invest 101:1581-90. 1998
    ..The presence of PON in HDL may thus be a major contributor to the antiatherogenicity of this lipoprotein...
  21. ncbi request reprint Polyphenolic flavonoids inhibit macrophage-mediated oxidation of LDL and attenuate atherogenesis
    M Aviram
    The Bruce Rappaport Faculty of Medicine Technion, The Rappaport Family Institute for Research in the Medical Sciences, and Rambam Medical Center, Haifa, Israel
    Atherosclerosis 137:S45-50. 1998
    ..The present review article summarizes our current data on these aspects of the antiatherogenic potential of polyphenolic flavonoids...
  22. ncbi request reprint Pomegranate juice supplementation to atherosclerotic mice reduces macrophage lipid peroxidation, cellular cholesterol accumulation and development of atherosclerosis
    M Kaplan
    The Lipid Research Laboratory, Bruce Rappaport Faculty of Medicine, Technion, The Rappaport Family Institute for Research in the Medical Sciences and Rambam Medical Center, Haifa 31096, Israel
    J Nutr 131:2082-9. 2001
    ..Moreover, a tannin-fraction isolated from PJ had a significant antiatherosclerotic activity...
  23. ncbi request reprint Oxidized monocyte-derived macrophages in aortic atherosclerotic lesion from apolipoprotein E-deficient mice and from human carotid artery contain lipid peroxides and oxysterols
    I Maor
    Lipid Research Laboratory, The Rappaport Family Institute for Research in the Medical Sciences and Rambam Medical Center, Haifa, Israel
    Biochem Biophys Res Commun 269:775-80. 2000
    ..The arterial oxidized macrophages could be considered key contributors to foam cell formation, the hallmark of early atherosclerosis...
  24. ncbi request reprint Paraoxonase (PON1) deficiency is associated with increased macrophage oxidative stress: studies in PON1-knockout mice
    Orit Rozenberg
    Lipid Research Laboratory, Department of Anatomy and Cell Biology, The Technion Faculty of Medicine, The Rappaport Family Institute for Research in the Medical Sciences and Rambam Medical Center, Haifa, Israel
    Free Radic Biol Med 34:774-84. 2003
    ....
  25. doi request reprint Pomegranate juice (PJ) consumption antioxidative properties on mouse macrophages, but not PJ beneficial effects on macrophage cholesterol and triglyceride metabolism, are mediated via PJ-induced stimulation of macrophage PON2
    Mira Rosenblat
    The Lipid Research Laboratory, Technion Faculty of Medicine, The Rappaport Family Institute for Research in the Medical Sciences, Rambam Medical Center, Haifa 31096, Israel
    Atherosclerosis 212:86-92. 2010
    ..To examine whether the beneficial effects of PJ consumption by mice on their macrophages are mediated via PJ-induced increment in serum paraoxonase 1 (PON1) activity and/or in macrophage PON2 expression...
  26. ncbi request reprint Increased plasma and lipoprotein lipid peroxidation in apo E-deficient mice
    T Hayek
    Lipid Research Laboratory, Rambam Medical Center, Bruce Rappaport Faculty of Medicine, Technion, Israel
    Biochem Biophys Res Commun 201:1567-74. 1994
    ....
  27. ncbi request reprint Angiotensin II administration to atherosclerotic mice increases macrophage uptake of oxidized ldl: a possible role for interleukin-6
    S Keidar
    Lipid Research Laboratory, Technion Faculty of Medicine, The Rappaport Family Institute for Research in the Medical Sciences and Rambam Medical Center, Haifa, Israel
    Arterioscler Thromb Vasc Biol 21:1464-9. 2001
    ..Thus, we conclude that a novel mechanism for Ang II atherogenicity, related to macrophage cholesterol accumulation and foam cell formation, may involve its stimulatory effect on macrophage uptake of Ox-LDL, a process mediated byIL-6...
  28. ncbi request reprint Oxidative stress increases the expression of the CD36 scavenger receptor and the cellular uptake of oxidized low-density lipoprotein in macrophages from atherosclerotic mice: protective role of antioxidants and of paraoxonase
    Bianca Fuhrman
    The Lipid Research Laboratory, Technion Faculty of Medicine, The Rappaport Family Institute for Research in the Medical Sciences and Rambam Medical Center, Haifa 31096, Israel
    Atherosclerosis 161:307-16. 2002
    ..In conclusion, our results are the first to demonstrate that macrophage lipid peroxidation stimulates CD36 mRNA expression and enhances the cellular uptake of Ox-LDL...
  29. ncbi request reprint White wine with red wine-like properties: increased extraction of grape skin polyphenols improves the antioxidant capacity of the derived white wine
    B Fuhrman
    The Lipid Research Laboratory, Technion Faculty of Medicine, The Rappaport Family Institute for Research in the Medical Sciences and Rambam Medical Center, Haifa, Israel
    J Agric Food Chem 49:3164-8. 2001
    ....
  30. ncbi request reprint Cell-induced copper ion-mediated low density lipoprotein oxidation increases during in vivo monocyte-to-macrophage differentiation
    Bianca Fuhrman
    Lipid Research Laboratory, Technion Faculty of Medicine, The Rappaport Family Institute for Research in the Medical Sciences and Rambam Medical Center, Haifa, Israel 31096
    Free Radic Biol Med 37:259-71. 2004
    ....
  31. ncbi request reprint Paraoxonase 2 (PON2) expression is upregulated via a reduced-nicotinamide-adenine-dinucleotide-phosphate (NADPH)-oxidase-dependent mechanism during monocytes differentiation into macrophages
    Maayan Shiner
    Lipid Research Laboratory, Technion Faculty of Medicine, The Rappaport Family Institute for Research in the Medical Sciences and Rambam Medical Center, Haifa 31096, Israel
    Free Radic Biol Med 37:2052-63. 2004
    ..PON2 stimulation may represent a compensatory mechanism against the increase in cellular superoxide anion production and atherogenesis...
  32. ncbi request reprint Mouse macrophage paraoxonase 2 activity is increased whereas cellular paraoxonase 3 activity is decreased under oxidative stress
    Mira Rosenblat
    The Lipid Research Laboratory, Technion Faculty of Medicine, The Rappaport Family Institute for Research in the Medical Sciences and Rambam Medical Center, Haifa, Israel
    Arterioscler Thromb Vasc Biol 23:468-74. 2003
    ..To determine whether paraoxonases (PONs) are expressed in macrophages and to analyze the oxidative stress effect on their expression and activities...
  33. doi request reprint Paraoxonase 1 (PON1) attenuates diabetes development in mice through its antioxidative properties
    Orit Rozenberg
    The Lipid Research Laboratory, The Technion Faculty of Medicine, The Rappaport Family Institute for Research in the Medical Sciences and Rambam Medical Center, Haifa, Israel
    Free Radic Biol Med 44:1951-9. 2008
    ....
  34. ncbi request reprint Macrophage NADPH oxidase activation, impaired cholesterol fluxes, and increased cholesterol biosynthesis in diabetic mice: a stimulatory role for D-glucose
    Tony Hayek
    Lipid Research Laboratory, Faculty of Medicine, Technion, Rambam Medical Center, Haifa, Israel
    Atherosclerosis 195:277-86. 2007
    ..The above mechanisms in diabetic mice could be the result of the effect of high D-glucose on macrophages...
  35. doi request reprint Monocyte-macrophage membrane possesses free radicals scavenging activity: stimulation by polyphenols or by paraoxonase 1 (PON1)
    M Rosenblat
    Lipid Research Laboratory, Rappaport Faculty of Medicine and Research Institute, Technion Israel Institute of Technology, Rambam Medical Center, Haifa, Israel
    Free Radic Res 47:257-67. 2013
    ..We conclude that monocytes-macrophages possess free radicals scavenging activity, which is decreased under atherogenic conditions, and increased upon cell enrichment with potent antioxidants such as nutritional polyphenols, or PON1...
  36. ncbi request reprint Flavonoids protect LDL from oxidation and attenuate atherosclerosis
    B Fuhrman
    The Lipid Research Laboratory, Technion Faculty of Medicine, The Rappaport Family Institute for Research in the Medical Sciences and Rambam Medical Center, Haifa, Israel
    Curr Opin Lipidol 12:41-8. 2001
    ..Thus, plant flavonoids, as potent natural antioxidants that protect against lipid peroxidation in arterial cells and lipoproteins, significantly attenuate the development of atherosclerosis...
  37. ncbi request reprint Antiatherogenicity of extra virgin olive oil and its enrichment with green tea polyphenols in the atherosclerotic apolipoprotein-E-deficient mice: enhanced macrophage cholesterol efflux
    Mira Rosenblat
    The Lipid Research Laboratory, Technion Faculty of Medicine, The Rappaport Family Institute for Research in the Medical Sciences, Rambam Medical Center, Haifa 31096, Israel
    J Nutr Biochem 19:514-23. 2008
    ..We thus conclude that EVOO possesses beneficial antiatherogenic effects, and its enrichment with GTPPs further improved these effects, leading to the attenuation of atherosclerosis development...
  38. ncbi request reprint Aldosterone administration to mice stimulates macrophage NADPH oxidase and increases atherosclerosis development: a possible role for angiotensin-converting enzyme and the receptors for angiotensin II and aldosterone
    Shlomo Keidar
    Lipid Research Laboratory, Technion Faculty of Medicine, the Rappaport Family Institute for Research in Medical Sciences and Rambam Medical Center, Haifa, Israel
    Circulation 109:2213-20. 2004
    ..We questioned the effect and mechanisms of action of administration of aldosterone to apolipoprotein E-deficient (E(0)) mice on their macrophages and aorta oxidative status and the ability of pharmacological agents to block this effect...
  39. ncbi request reprint Macrophage paraoxonase 2 (PON2) expression is up-regulated by pomegranate juice phenolic anti-oxidants via PPAR gamma and AP-1 pathway activation
    Maayan Shiner
    Lipid Research Laboratory, Technion Faculty of Medicine, The Rappaport Family Institute for Research in the Medical Sciences and Rambam Medical Center, Haifa 31096, Israel
    Atherosclerosis 195:313-21. 2007
    ....
  40. ncbi request reprint Decreased macrophage paraoxonase 2 expression in patients with hypercholesterolemia is the result of their increased cellular cholesterol content: effect of atorvastatin therapy
    Mira Rosenblat
    Lipid Research Laboratory, Technion Faculty of Medicine, The Rappaport Family Institute for Research in the Medical Sciences and Rambam Medical Center, Haifa, Israel
    Arterioscler Thromb Vasc Biol 24:175-80. 2004
    ..To analyze paraoxonase2 (PON2) expression in human monocyte-derived macrophages (HMDM) from patients with hypercholesterolemia in relation to cellular cholesterol and oxidative stress...
  41. ncbi request reprint Pomegranate juice sugar fraction reduces macrophage oxidative state, whereas white grape juice sugar fraction increases it
    Orit Rozenberg
    The Lipid Research Laboratory, The Technion Faculty of Medicine, The Rappaport Family Institute for Research in the Medical Sciences and Rambam Medical Center, Haifa, Israel
    Atherosclerosis 188:68-76. 2006
    ..These antioxidant/antiatherogenic effects could be due to the presence of unique complex sugars and/or phenolic sugars in PJ...
  42. ncbi request reprint Pomegranate juice inhibits oxidized LDL uptake and cholesterol biosynthesis in macrophages
    Bianca Fuhrman
    Lipid Research Laboratory, Technion Faculty of Medicine, The Rappaport Family Institute for Research in the Medical Sciences, Rambam Medical Center, Haifa 31096, Israel
    J Nutr Biochem 16:570-6. 2005
    ..We conclude that PJ-mediated suppression of Ox-LDL degradation and of cholesterol biosynthesis in macrophages can lead to reduced cellular cholesterol accumulation and foam cell formation...
  43. ncbi request reprint Anti-oxidative effects of pomegranate juice (PJ) consumption by diabetic patients on serum and on macrophages
    Mira Rosenblat
    The Lipid Research Laboratory, Technion Faculty of Medicine, The Rappaport Family Institute for Research in the Medical Sciences, Rambam Medical Center, 31096 Haifa, Israel
    Atherosclerosis 187:363-71. 2006
    ....
  44. ncbi request reprint Angiotensin II atherogenicity in apolipoprotein E deficient mice is associated with increased cellular cholesterol biosynthesis
    S Keidar
    Bruce Rappaport Technion Faculty of Medicine and the Rappaport Family Institute for Research in the Medical Sciences, Haifa, Israel
    Atherosclerosis 146:249-57. 1999
    ....
  45. ncbi request reprint Macrophage foam-cell formation in streptozotocin-induced diabetic mice: stimulatory effect of glucose
    Tony Hayek
    The Lipid Research Laboratory, The Bruce Rappaport Faculty of Medicine, Technion, The Rappaport Family Institute for Research in the Medical Sciences, Rambam Medical Center, 31096 Haifa, Israel
    Atherosclerosis 183:25-33. 2005
    ..Diabetes is associated with an increased risk for atherosclerosis. We investigated the effect of diabetes induction on atherogenesis and on macrophage-foam cell formation...
  46. ncbi request reprint Anti-oxidant and anti-atherogenic properties of liposomal glutathione: studies in vitro, and in the atherosclerotic apolipoprotein E-deficient mice
    Mira Rosenblat
    The Lipid Research Laboratory, Technion Faculty of Medicine, The Rappaport Family Institute for Research in the Medical Sciences, Rambam Medical Center, Haifa 31096, Israel
    Atherosclerosis 195:e61-8. 2007
    ..We thus conclude that liposomal glutathione possesses anti-oxidative and anti-atherogenic properties towards lipoproteins and macrophages, leading to attenuation of atherosclerosis development...
  47. ncbi request reprint Paraoxonase 1 (PON1) is a more potent antioxidant and stimulant of macrophage cholesterol efflux, when present in HDL than in lipoprotein-deficient serum: relevance to diabetes
    Mira Rosenblat
    The Lipid Research Laboratory, Technion Faculty of Medicine, The Rappaport Family Institute for Research in the Medical Sciences and Rambam Medical Center, 31096 Haifa, Israel
    Atherosclerosis 187:74-81. 2006
    ..We conclude that PON1 is less antiatherogenic when present in LPDS than in HDL. The abnormal serum PON1 distribution in diabetic patients, could be responsible for the accelerated atherosclerosis development in these patients...
  48. ncbi request reprint Antiatherosclerotic effects of licorice extract supplementation on hypercholesterolemic patients: increased resistance of LDL to atherogenic modifications, reduced plasma lipid levels, and decreased systolic blood pressure
    Bianca Fuhrman
    Lipid Research Laboratory, Technion Faculty of Medicine, The Rappaport Family Institute for Research in the Medical Sciences and Rambam Medical Center, Haifa, Israel
    Nutrition 18:268-73. 2002
    ..In the present study, we extended our investigation to analyze the antiatherogenic effects of licorice-root extract consumption in moderately hypercholesterolemic patients...
  49. ncbi request reprint Oxysterol-induced activation of macrophage NADPH-oxidase enhances cell-mediated oxidation of LDL in the atherosclerotic apolipoprotein E deficient mouse: inhibitory role for vitamin E
    Mira Rosenblat
    The Lipid Research Laboratory, Rambam Medical Center, 31096 Haifa, Israel
    Atherosclerosis 160:69-80. 2002
    ....
  50. ncbi request reprint Tissue angiotensin-converting-enzyme (ACE) deficiency leads to a reduction in oxidative stress and in atherosclerosis: studies in ACE-knockout mice type 2
    Tony Hayek
    Lipid Research Laboratory, Bruce Rappaport Faculty of Medicine, Technion, Rappaport Institute for Research in the Medical Sciences, Rambam Medical Center, Haifa, Israel
    Arterioscler Thromb Vasc Biol 23:2090-6. 2003
    ..CONCLUSIONS: Reduction of tissue ACE with the ACE-knockout mouse type-2 model inhibited oxidative stress and atherogenesis...
  51. ncbi request reprint Retention of oxidized LDL by extracellular matrix proteoglycans leads to its uptake by macrophages: an alternative approach to study lipoproteins cellular uptake
    M Kaplan
    Lipid Research Laboratory, Bruce Rappaport Faculty of Medicine, Technion, The Rappaport Family Institute for Research in the Medical Sciences and Rambam Medical Center, Haifa, Israel
    Arterioscler Thromb Vasc Biol 21:386-93. 2001
    ..This may represent a physiopathological phenomenon that leads to cholesterol and oxysterol accumulation in arterial macrophages, the hallmark of early atherosclerosis...
  52. ncbi request reprint Ramipril administration to atherosclerotic mice reduces oxidized low-density lipoprotein uptake by their macrophages and blocks the progression of atherosclerosis
    Tony Hayek
    The Lipid Research Laboratory, The Bruce Rappaport Faculty of Medicine, Technion, The Rappaport Family Institute for Research in the Medical Sciences and Rambam Medical Center, 31096 Haifa, Israel
    Atherosclerosis 161:65-74. 2002
    ....
  53. ncbi request reprint Effect of eplerenone, a selective aldosterone blocker, on blood pressure, serum and macrophage oxidative stress, and atherosclerosis in apolipoprotein E-deficient mice
    Shlomo Keidar
    Lipid Research Laboratory, Technion Faculty of Medicine, Rambam Medical Center, Haifa, Israel
    J Cardiovasc Pharmacol 41:955-63. 2003
    ..These data suggest that aldosterone could have a significant pro-oxidative role in the pathogenesis of atherosclerosis...
  54. doi request reprint Paraoxonases (PON1, PON2, PON3) analyses in vitro and in vivo in relation to cardiovascular diseases
    Michael Aviram
    Lipid Research Laboratory, Technion Faculty of Medicine and Department of Laboratory Medicine, Rambam Medical Center, Haifa, Israel
    Methods Mol Biol 477:259-76. 2008
    ....
  55. ncbi request reprint Increased macrophage glutathione content reduces cell-mediated oxidation of LDL and atherosclerosis in apolipoprotein E-deficient mice
    Mira Rosenblat
    The Lipid Research Laboratory, Technion Faculty of Medicine, The Rappaport Family Institute for Research in the Medical Sciences and Rambam Medical Center, 31096 Haifa, Israel
    Atherosclerosis 163:17-28. 2002
    ....
  56. ncbi request reprint Pomegranate byproduct administration to apolipoprotein e-deficient mice attenuates atherosclerosis development as a result of decreased macrophage oxidative stress and reduced cellular uptake of oxidized low-density lipoprotein
    Mira Rosenblat
    The Lipid Research Laboratory, Technion Faculty of Medicine, The Rappaport Family Institute for Research in the Medical Sciences, Rambam Medical Center, Haifa, Israel
    J Agric Food Chem 54:1928-35. 2006
    ..It was thus concluded that PBP significantly attenuates atherosclerosis development by its antioxidant properties...
  57. ncbi request reprint Lysophosphatidylcholine (LPC) attenuates macrophage-mediated oxidation of LDL
    Mira Rosenblat
    The Lipid Research Laboratory, Technion Faculty of Medicine, The Rappaport Family Institute for Research in the Medical Sciences, Rambam Medical Center, Haifa, Israel
    Biochem Biophys Res Commun 344:1271-7. 2006
    ..We thus conclude that inhibition of macrophage-mediated oxidation of LDL by LPC can contribute to attenuation of macrophage foam cell formation and atherosclerotic lesion development...
  58. ncbi request reprint The catalytic histidine dyad of high density lipoprotein-associated serum paraoxonase-1 (PON1) is essential for PON1-mediated inhibition of low density lipoprotein oxidation and stimulation of macrophage cholesterol efflux
    Mira Rosenblat
    Lipid Research Laboratory, Technion Faculty of Medicine, Haifa 31096, Israel
    J Biol Chem 281:7657-65. 2006
    ....
  59. ncbi request reprint Macrophage paraoxonase 2 (PON2) expression is upregulated by unesterified cholesterol through activation of the phosphatidylinositol 3-kinase (PI3K) pathway
    Maayan Shiner
    Lipid Research Laboratory, Technion Faculty of Medicine, The Rappaport Family Institute for Research in the Medical Sciences and Rambam Medical Center, Haifa 31096, Israel
    Biol Chem 388:1353-8. 2007
    ..Thus, we conclude from our data that macrophage PON2 expression is upregulated in UC-enriched macrophages through activation of the PI(3)K signal pathway...
  60. pmc Paraoxonase 2 attenuates macrophage triglyceride accumulation via inhibition of diacylglycerol acyltransferase 1
    Mira Rosenblat
    Lipid Research Laboratory, Technion Faculty of Medicine, Rappaport Family Institute for Research in the Medical Sciences, Rambam Medical Center, Haifa, Israel
    J Lipid Res 50:870-9. 2009
    ..We thus conclude that PON2 attenuates macrophage triglyceride accumulation and foam cell formation via inhibition of microsomal DGAT1 activity, which appears to be sensitive to oxidative state...
  61. doi request reprint Paraoxonase 2 (PON2) decreases high glucose-induced macrophage triglycerides (TG) accumulation, via inhibition of NADPH-oxidase and DGAT1 activity: studies in PON2-deficient mice
    Edna Meilin
    The Lipid Research Laboratory, Technion, The Rappaport Family Institute for Research in the Medical Science, Rambam Medical Center, Haifa, Israel
    Atherosclerosis 208:390-5. 2010
    ..The present study investigates the role of paraoxonase 2 (PON2) in the attenuation of macrophage triglycerides (TG) biosynthesis, and oxidative stress, under diabetic conditions...
  62. ncbi request reprint Red wine administration to apolipoprotein E-deficient mice reduces their macrophage-derived extracellular matrix atherogenic properties
    Marielle Kaplan
    Lipid Research Laboratory, Technion Faculty of Medicine, The Rappaport Family Institute for Research in the Medical Sciences, Haifa, Israel
    Biol Res 37:239-45. 2004
    ..The present study thus clearly demonstrated the inhibitory effect of red wine consumption by E0 mice on their peritoneal macrophage-derived extracellular matrix atherogenic properties...
  63. doi request reprint Increased macrophage cholesterol biosynthesis and decreased cellular paraoxonase 2 (PON2) expression in Delta6-desaturase knockout (6-DS KO) mice: beneficial effects of arachidonic acid
    Mira Rosenblat
    The Lipid Research Laboratory, Technion Faculty of Medicine, The Rappaport Family Institute for Research in the Medical Sciences, Rambam Medical Center, 31096 Haifa, Israel
    Atherosclerosis 210:414-21. 2010
    ..To analyze the possible role of arachidonic acid (AA) in macrophage cholesterol biosynthesis and in PON2 expression...
  64. ncbi request reprint Human serum paraoxonase 1 decreases macrophage cholesterol biosynthesis: possible role for its phospholipase-A2-like activity and lysophosphatidylcholine formation
    Orit Rozenberg
    Technion Faculty of Medicine, The Rappaport Institute for Research in Medical Sciences, Rambam Medical Center, Haifa
    Arterioscler Thromb Vasc Biol 23:461-7. 2003
    ..To assess a possible mechanism for this relationship, we analyzed the effect of PON1 on cellular cholesterol biosynthesis...
  65. ncbi request reprint Angiotensin II-modified LDL is taken up by macrophages via the scavenger receptor, leading to cellular cholesterol accumulation
    S Keidar
    Lipid Research Laboratory, Rambam Medical Center, Rappaport Institute for Research in the Medical Sciences, Bruce Rappaport Technion Faculty of Medicine, Haifa, Israel
    Arterioscler Thromb Vasc Biol 16:97-105. 1996
    ..We conclude that Ang II can modify LDL to a form that is not oxidized or aggregated but is still taken up at an enhanced rate by macrophages via the scavenger receptor...
  66. ncbi request reprint Role of HDL apolipoprotein E in cellular cholesterol efflux: studies in apo E knockout transgenic mice
    T Hayek
    Lipid Research Laboratory, Rambam Medical Center, Bruce Rappaport Faculty of Medicine, Technion, Israel
    Biochem Biophys Res Commun 205:1072-8. 1994
    ..It is concluded that the enhanced atherosclerosis in apo E-deficient mice could be related, at least partly, to the impaired efflux of LDL derived cholesterol from macrophages of the arterial wall...
  67. doi request reprint Effects of date ( Phoenix dactylifera L., Medjool or Hallawi Variety) consumption by healthy subjects on serum glucose and lipid levels and on serum oxidative status: a pilot study
    Wasseem Rock
    The Lipid Research Laboratory, Rappaport Faculty of Medicine and the Rappaport Family Institute for Research in the Medical Sciences, Technion Israel Institute of Technology, Haifa, Israel
    J Agric Food Chem 57:8010-7. 2009
    ....
  68. ncbi request reprint S-Glutathionylation regulates HDL-associated paraoxonase 1 (PON1) activity
    Orit Rozenberg
    The Lipid Research Laboratory, The Technion Faculty of Medicine, The Rappaport Family Institute for Research in the Medical Sciences and Rambam Medical Center, 31096 Haifa, Israel
    Biochem Biophys Res Commun 351:492-8. 2006
    ..We thus conclude that HDL-associated serum PON1 can undergo S-glutathionylation under oxidative stress with a consequent reversible inactivation...
  69. ncbi request reprint Haptoglobin genotype is a regulator of reverse cholesterol transport in diabetes in vitro and in vivo
    Rabea Asleh
    Rappaport Faculty of Medicine, Technion Israel Institute of Technology, POB 9649, Haifa 31096, Israel
    Circ Res 99:1419-25. 2006
    ..03). reverse cholesterol transport is decreased in Hp2-2 DM. This may explain in part the increased atherosclerotic burden found in Hp2-2 DM individuals...
  70. ncbi request reprint Serum paraoxonase activity and the extent of lipid peroxidation are not affected by increased levels of human apolipoprotein A-I: studies in transgenic mice
    Mira Rosenblat
    The Lipid Research Laboratory, Technion Faculty of Medicine, The Rappaport Family Institute for Research in the Medical Sciences and Rambam Medical Center, Haifa, Israel
    Clin Chem Lab Med 40:9-14. 2002
    ..We thus conclude that the increased human apoA-I concentration in the mouse serum neither affect serum paraoxonase activity, nor protects against lipid peroxidation, whereas paraoxonase significantly inhibits serum lipid peroxidation...
  71. ncbi request reprint Omapatrilat decreased macrophage oxidative status and atherosclerosis progression in atherosclerotic apolipoprotein E-deficient mice
    Tony Hayek
    Lipid Research Laboratory, The Bruce Rappaport Faculty of Medicine, Technion, Israel
    J Cardiovasc Pharmacol 43:140-7. 2004
    ..Angiotensin-converting enzyme (ACE) inhibitors attenuate atherosclerosis and oxidative stress in animal models. Omapatrilat, a VasoPeptidase-inhibitor, selectively inhibits both Neutral-Endo-Peptidase (NEP) and ACE...
  72. ncbi request reprint Paraoxonase 1 (PON1) enhances HDL-mediated macrophage cholesterol efflux via the ABCA1 transporter in association with increased HDL binding to the cells: a possible role for lysophosphatidylcholine
    Mira Rosenblat
    The Lipid Research Laboratory, Technion Faculty of Medicine, The Rappaport Family Institute for Research in the Medical Sciences and Rambam Medical Center, Haifa 31096, Israel
    Atherosclerosis 179:69-77. 2005
    ....
  73. ncbi request reprint Oxidative stress increases the expression of the angiotensin-II receptor type 1 in mouse peritoneal macrophages
    Shlomo Keidar
    The Lipid Research Laboratory, Technion Faculty of Medicine, The Rappaport Family Institute in the Medical Sciences and Rambam Medical Center, Haifa, Israel
    J Renin Angiotensin Aldosterone Syst 3:24-30. 2002
    ..This phenomenon can stimulate the interaction of Ang II with macrophages and hence accelerate macrophage foam cell formation and early atherogenesis...
  74. ncbi request reprint Paraoxonase 1 (PON1) attenuates macrophage oxidative status: studies in PON1 transfected cells and in PON1 transgenic mice
    Orit Rozenberg
    The Lipid Research Laboratory, Department of Anatomy and Cell Biology, The Technion Faculty of Medicine, The Rappaport Family Institute for Research in the Medical Sciences, Rambam Medical Center, Haifa, Israel
    Atherosclerosis 181:9-18. 2005
    ..Thus, the aim of the present study is to characterize the direct effect of PON1 on oxidative status processes in macrophages...
  75. ncbi request reprint Dietary supplementation of a natural isomer mixture of beta-carotene inhibits oxidation of LDL derived from patients with diabetes mellitus
    Y Levy
    Lipid Research and Diabetes and Metabolism Units, Rambam Medical Center, Bruce Rappaport Faculty of Medicine, Technion, Israel
    Ann Nutr Metab 44:54-60. 2000
    ..Therefore, we compared the oxidation of LDL derived from patients with diabetes to normoglycemic controls and followed-up the effect of dietary beta-carotene supplementation on LDL oxidation...
  76. ncbi request reprint Consumption of a novel dietary formula of plant sterol esters of canola oil fatty acids, in a canola oil matrix containing 1,3-diacylglycerol, reduces oxidative stress in atherosclerotic apolipoprotein E-deficient mice
    Bianca Fuhrman
    The Lipid Research Laboratory, Technion Faculty of Medicine and Rambam Medical Center, 31096 Haifa, Israel
    J Agric Food Chem 55:2028-33. 2007
    ..These findings indicate that PS-CO supplementation is beneficial in reducing serum lipid levels, and serum and macrophage oxidative stress, thus contributing to the reduction in atherogenic risk factors...
  77. ncbi request reprint Valsartan therapy has additive anti-oxidative effect to that of fluvastatin therapy against low-density lipoprotein oxidation: studies in hypercholesterolemic and hypertensive patients
    Osamah Hussein
    Lipid Research Laboratory, Internal Medicine Department A, Sieff Government Hospital, Safed, Israel
    J Cardiovasc Pharmacol 40:28-34. 2002
    ..This may be related both to the anti-oxidative properties of valsartan and to the blocking of angiotensin II-induced oxidative stress...
  78. ncbi request reprint Preservation of paraoxonase activity by wine flavonoids: possible role in protection of LDL from lipid peroxidation
    Bianca Fuhrman
    Lipid Research Laboratory, Technion Faculty of Medicine, The Rappaport Family Institute for Research in the Medical Sciences, and Rambam Medical Center, Haifa, Israel
    Ann N Y Acad Sci 957:321-4. 2002
    ....
  79. doi request reprint Urokinase activates macrophage PON2 gene transcription via the PI3K/ROS/MEK/SREBP-2 signalling cascade mediated by the PDGFR-beta
    Bianca Fuhrman
    The Lipid Research Laboratory, Technion Faculty of Medicine, The Rappaport Family Institute for Research in the Medical Sciences, Rambam Medical Center, Haifa 31096, Israel
    Cardiovasc Res 84:145-54. 2009
    ..Here, we investigated the signalling pathway that leads to the expression of PON2 in macrophages in response to uPA...
  80. ncbi request reprint Acetylcholine esterase protects LDL against oxidation
    Bianca Fuhrman
    The Lipid Research Laboratory, Technion Faculty of Medicine, The Rappaport Family Institute for Research in the Medical Sciences and Rambam Medical Center, Haifa, Israel
    Biochem Biophys Res Commun 322:974-8. 2004
    ..We conclude that AChE, similar to PON1, can hydrolyze lipid peroxides and thus may prevent the accumulation of oxidized LDL and attenuate atherosclerosis development...
  81. doi request reprint Urokinase plasminogen activator upregulates paraoxonase 2 expression in macrophages via an NADPH oxidase-dependent mechanism
    Bianca Fuhrman
    Lipid Research Laboratory, Rambam Medical Center, Haifa, Israel
    Arterioscler Thromb Vasc Biol 28:1361-7. 2008
    ..Increased macrophage oxidative stress in turn was shown to enhance PON2 expression. In the present study we investigated the effect of uPA on macrophage PON2 expression in relation to cellular oxidative stress...
  82. doi request reprint Pomegranate juice polyphenols increase recombinant paraoxonase-1 binding to high-density lipoprotein: studies in vitro and in diabetic patients
    Bianca Fuhrman
    Rambam Medical Center, Rappaport Family Institute for Research in Medical Sciences and Technion Faculty of Medicine, Haifa, Israel
    Nutrition 26:359-66. 2010
    ....
  83. doi request reprint Paraoxonase 1 (PON1) deficiency in mice is associated with reduced expression of macrophage SR-BI and consequently the loss of HDL cytoprotection against apoptosis
    Bianca Fuhrman
    The Lipid Research Laboratory, Technion Faculty of Medicine, The Rappaport Family Institute for Research in the Medical Sciences, and Rambam Medical Center, 31096 Haifa, Israel
    Atherosclerosis 211:61-8. 2010
    ..Paraoxonase 1 (PON1) was shown to stimulate HDL binding and HDL-mediated cholesterol efflux from macrophages. This study examined the role of PON1 in the expression of proteins that enhance macrophage HDL binding, i.e. ABCA1 and SR-BI...
  84. ncbi request reprint Grape powder polyphenols attenuate atherosclerosis development in apolipoprotein E deficient (E0) mice and reduce macrophage atherogenicity
    Bianca Fuhrman
    Lipid Research Laboratory and Department of Anatomy and Cell Biology, Technion Faculty of Medicine, Rappaport Family Institute for Research in the Medical Sciences and Rambam Medical Center, Haifa, Israel
    J Nutr 135:722-8. 2005
    ..Both of these processes can eventually reduce macrophage cholesterol accumulation and foam cell formation and hence attenuate atherosclerosis development...
  85. ncbi request reprint A mouse model for human atherosclerosis: long-term histopathological study of lesion development in the aortic arch of apolipoprotein E-deficient (E0) mice
    Raymond Coleman
    Department of Anatomy and Cell Biology, Rappaport Faculty of Medicine, Technion Israel Institute of Technology, P O Box 9649, Haifa 31096, Israel
    Acta Histochem 108:415-24. 2006
    ....
  86. ncbi request reprint Urokinase plasminogen activator (uPA) stimulates cholesterol biosynthesis in macrophages through activation of SREBP-1 in a PI3-kinase and MEK-dependent manner
    Bianca Fuhrman
    The Lipid Research Laboratory, Technion Faculty of Medicine, The Rappaport Family Institute for Research in the Medical Sciences, and Rambam Medical Center, Haifa 31096, Israel
    Atherosclerosis 195:e108-16. 2007
    ..These findings provide new insight into the atherogenicity of uPA and may suggest new novel therapeutic means...
  87. ncbi request reprint Ox-LDL induces monocyte-to-macrophage differentiation in vivo: Possible role for the macrophage colony stimulating factor receptor (M-CSF-R)
    Bianca Fuhrman
    The Lipid Research Laboratory, Technion Faculty of Medicine, The Rappaport Family Institute for Research in the Medical Sciences and Rambam Medical Center, Haifa 31096, Israel
    Atherosclerosis 196:598-607. 2008
    ..We thus conclude that Ox-LDL induces monocyte differentiation to macrophages in vivo and this phenomenon involves activation of the M-CSF-receptor...
  88. ncbi request reprint Atorvastatin therapy in hypercholesterolemic patients suppresses cellular uptake of oxidized-LDL by differentiating monocytes
    Bianca Fuhrman
    The Lipid Research Laboratory, Technion Faculty of Medicine, The Rappaport Family Institute for Research in the Medical Sciences and Rambam Medical Center, 31096, Haifa, Israel
    Atherosclerosis 164:179-85. 2002
    ..These effects may account for the attenuation of atherogenesis in hypercholesterolemic patients following atorvastatin treatment...
  89. ncbi request reprint Plasmalogen phospholipids are involved in HDL-mediated cholesterol efflux: insights from investigations with plasmalogen-deficient cells
    H Mandel
    Department of Pediatrics, Rambam Medical Center, Haifa, Israel
    Biochem Biophys Res Commun 250:369-73. 1998
    ..The novel finding that HDL-MCE is reduced in plasmalogen-deficient cells and increases following plasmalogen restoration leads us to suggest that plasmalogen has an important function in the mediation of cellular cholesterol efflux...
  90. pmc Compound heterozygosity for abetalipoproteinaemia and familial hypobetalipoproteinaemia
    S Keidar
    Lipid Research Centre, Rambam Medical Centre, Haifa, Israel
    J Med Genet 27:133-4. 1990
    ..This is the first report of abetalipoproteinaemia resulting from compound heterozygosity for abetalipoproteinaemia and familial hypobetalipoproteinaemia...
  91. ncbi request reprint Choosing an oestrogen replacement therapy in young adult women with Turner syndrome
    H Guttmann
    Department of Paediatrics, Rambam Medical Center, Haifa, Israel
    Clin Endocrinol (Oxf) 54:159-64. 2001
    ..In the short term, neither regimen is effective for bone turnover in adult women with Turner syndrome...
  92. doi request reprint Consumption of polyphenolic-rich beverages (mostly pomegranate and black currant juices) by healthy subjects for a short term increased serum antioxidant status, and the serum's ability to attenuate macrophage cholesterol accumulation
    Mira Rosenblat
    The Lipid Research Laboratory, Technion Israel Institute of Technology Faculty of Medicine, The Rappaport Family Institute for Research in the Medical Sciences, Rambam Medical Center, Haifa 31096, Israel
    Food Funct 1:99-109. 2010
    ..In this respect, 100% Wonderful-variety pomegranate and 100% black currant juices were most the potent...
  93. ncbi request reprint Phase II study of pomegranate juice for men with rising prostate-specific antigen following surgery or radiation for prostate cancer
    Allan J Pantuck
    Department of Urology, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California 90095 1738, USA
    Clin Cancer Res 12:4018-26. 2006
    ..We sought to determine the effects of pomegranate juice (a major source of antioxidants) consumption on prostate-specific antigen (PSA) progression in men with a rising PSA following primary therapy...
  94. ncbi request reprint Characterization of oxidative stress in blood from diabetic vs. hypercholesterolaemic patients, using a novel synthesized marker
    Andrea Szuchman
    The Laboratory of Natural Medicinal Compounds, Migal Galilee Technology Center, Kiryat Shmona 11016, Israel
    Biomarkers 13:119-31. 2008
    ..The use of an exogenous marker to characterize OS in blood samples yields important information on the extent of OS, and can provide a fingerprint for the early identification of different pathological conditions associated with OS...
  95. ncbi request reprint Lipid peroxidation and atherosclerosis: the importance of selected patient group analysis
    Michael Aviram
    Isr Med Assoc J 5:734-5. 2003
  96. doi request reprint Comparison of antioxidant potency of commonly consumed polyphenol-rich beverages in the United States
    Navindra P Seeram
    Center for Human Nutrition, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA
    J Agric Food Chem 56:1415-22. 2008
    ..Although in vitro antioxidant potency does not prove in vivo biological activity, there is also consistent clinical evidence of antioxidant potency for the most potent beverages including both PJ and red wine...
  97. ncbi request reprint Red wine consumption and inhibition of LDL oxidation: what are the important components?
    Alan Howard
    The Howard Foundation, Whitehill House, Granhams Road, Great Shelford, Cambridge, UK
    Med Hypotheses 59:101-4. 2002
    ..In the present report, we have examined the polyphenol composition of red wines used in the various studies and have suggested a few possible reasons for discrepancies in their effects on lipoprotein oxidation...
  98. ncbi request reprint Oxidative stress in arteriogenic erectile dysfunction: prophylactic role of antioxidants
    Kazem M Azadzoi
    Department of Urology, Boston University School of Medicine and Veterans Affairs Boston Healthcare System, Boston, Massachusetts, USA
    J Urol 174:386-93. 2005
    ..We searched for markers of oxidative stress in cavernous ischemia and examined the effect of long-term antioxidant intake on arteriogenic erectile dysfunction (ED) in the rabbit...
  99. doi request reprint Consumption of wonderful variety pomegranate juice and extract by diabetic patients increases paraoxonase 1 association with high-density lipoprotein and stimulates its catalytic activities
    Wasseem Rock
    Internal Medicine C Department, Ha Emek Medical Center, Afula, Israel
    J Agric Food Chem 56:8704-13. 2008
    ..These beneficial effects of pomegranate consumption on serum PON1 stability and activity could lead to retardation of atherosclerosis development in diabetic patients...
  100. ncbi request reprint Antioxidant activity, polyphenol content, and related compounds in different fruit juices and homogenates prepared from 29 different pomegranate accessions
    Revital Tzulker
    Migal Galilee Technology Center, P O Box 831, Kiryat Shmona, 11016, Israel
    J Agric Food Chem 55:9559-70. 2007
    ..Unlike the arils, the antioxidant level in the homogenates correlated significantly to the content of the four hydrolyzable tannins in which punicalagin is predominant, while no correlation was found to the level of anthocyanins...