Doron Aronson

..Increased levels of systemic markers of inflammation have been reported in patients with impaired lung function due to obstructive or restrictive lung disease...

..To study the prevalence and long-term prognostic significance of changes in haemoglobin levels during hospital course in survivors of acute myocardial infarction (AMI)...

..However, the existence of the obesity paradox in AMI patients remains controversial...

..The increased mortality observed in transfused patients with nadir hemoglobin above 8 g/dL underscores the clinical difficulty of balancing risks and benefits of RBC transfusion in the setting of ACS...

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..Small elevations of serum creatinine may serve as a simple marker to identify patients at a very high risk...

..Further studies are required to determine if plasma sodium levels may serve as a simple marker to identify patients at high risk...

..Our study shows that dynamic changes in renal function during acute myocardial infarction are strongly related to long-term mortality and heart failure...

..Different software algorithms have at times yielded conflicting results. The aim of this study was to determine normal myocardial mechanical parameters in a healthy population using Velocity Vector Imaging...

..Obesity is strongly associated with elevated CRP levels, potentially confounding the relationship between CRP and CAD severity...

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..However, few data are available concerning the long-term prognostic value of elevated fasting glucose during the acute phase of infarction...

..In conclusion, in a large cohort of patients with AMI, there was a graded positive association between increased CRP and new-onset AF. Inflammation may contribute to the development of AF in the setting of AMI...

..In AMI, PH at the index admission is a useful marker in unmasking latent subclinical HF and predicting the development of overt HF...

..99, CI: 1.29-6.9; p=0.01). Therefore, adjunctive therapy with GP IIbIIIa inhibitors during primary PCI is associated with improved short-term outcomes and one-year survival without an increased risk of bleeding...

..Finally, among patients with diabetes, Hp 1-1 was associated with smaller infarct size. This study demonstrates that in patients with diabetes and AMI, the Hp type is an important determinant of clinical outcome and infarct size...

..In conclusion, in patients with AMI, presence of advanced diastolic dysfunction was independently associated with new-onset AF, suggesting that increased filling pressures may contribute to the development of AF after AMI...

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..CONCLUSIONS: Elevations of liver enzymes are associated with higher CRP concentrations. Hepatic inflammation secondary to liver steatosis is a potential contributor to the low-grade inflammation associated with the metabolic syndrome...

..Compensatory mechanics were lost in patients with severe LV dysfunction. AVR partly reversed these changes in patients with LV dysfunction...

..However, there are no data regarding the contribution of diastolic dysfunction to the development of heart failure (HF) in diabetic patients after acute myocardial infarction...

..The effect of statins is driven largely by the reduction in events in patients without concomitant hemodynamically significant MR...

..These results underscore the role of systemic inflammation in the pathogenesis of periprocedural myocardial injury...

..We sought to understand the importance of oxidative stress in explaining why the haptoglobin (Hp) genotype determines myocardial infarction (MI) size in diabetes mellitus (DM)...

..15 to 0.75; p = 0.008) for patients in the third CRP tertile (p for trend = 0.008). In conclusion, an inverse graded association exists between CRP and the presence of coronary collaterals in patients with stable angina pectoris...

..Most of these patients have an alternative explanation for cardiac troponin increase. Cardiac diagnostic procedures are frequently unhelpful in excluding a non-ACS-related troponin increase...

..The pathophysiology of low-grade inflammation is complex, and multiple intercorrelated conditions have been associated with elevated CRP...

..Changes in FG during hospitalization are simple and sensitive indicators of dynamic changes in risk...

..We sought to study relationship between cardiorespiratory fitness and C-reactive protein (CRP) in subjects with the metabolic syndrome...

..We aimed to study the association between multidetector row computed tomography (MDCT) perfusion defects and ventricular remodeling post-AMI...

..However, it is unknown which specific subset of leukocytes best correlates with increased risk of adverse outcome...

..Whereas the resolution of anemia after AMI is associated with better outcomes, persistent or new-onset anemia portends increased risk for heart failure and death...

..The objectives of our study were to determine the distribution of TR severity in relation to pulmonary artery systolic pressure (PASP) and to define the determinants of TR severity...

..Few data are available on the prognostic significance of blood urea nitrogen (BUN), a sensitive marker of hemodynamic alterations and renal perfusion...

..This study was designed to test the hypothesis that functional mitral regurgitation (FMR) occurring after AMI may promote AF by producing left atrial volume overload...

..These findings suggest that C-reactive protein levels may be related to inflammatory processes associated with infarct expansion and postinfarction ventricular remodeling...

..We sought to demonstrate the incidence of LVT after AMI in patients treated with PPCI compared with those treated with thrombolysis or with conservative management...

..In this setting, elevated blood urea nitrogen levels probably reflect the cumulative effects of hemodynamic and neurohormonal alterations that result in renal hypoperfusion...

..In conclusion, there is a graded, independent association between increased RDW and mortality after AMI. An increase in RDW during hospitalization also portends adverse clinical outcome...

..However, few data are available on the relationship between ischemic MR and the long-term risk for HF...

..6 +/- 15 months. Therefore, during long-term follow up following IRT for the prevention of ISR, half of all patients developed a major cardiovascular event, mainly due to the need for repeat revascularization procedures...

..We sought to recapitulate these findings in DM mice genetically modified at the Hp locus...

..Trans-aortic pressure gradient in patients with aortic stenosis and left ventricular systolic dysfunction is typically low but occasionally high...

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..We conclude that an injectable in-situ forming hydrogel can act as a cardiomyocyte cell-carrier and add to the beneficial effects of the grafted cells in preventing unfavorable post-infarction cardiac remodeling...

..We sought to test the hypothesis that vitamin E could reduce cardiovascular events in DM individuals with the Hp 2-2 genotype, a subgroup that comprises 2% to 3% of the general population...

..4, 3 df, P<0.0001). CONCLUSIONS: There is a graded relation between elevated FG and AG and 30-day mortality in patients with acute myocardial infarction. FG is superior to AG in the assessment of short-term risk...

..In the present study we assessed whether hybrid single photon emission computed tomography (SPECT)/coronary computed tomography angiography (CCTA) technology could be an appropriate tool in stratifying patients with NSTE-ACS...

..We found that the association of PP with outcome in this setting is reversed, with low PP being an independent predictor of mortality...

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..C-reactive protein (CRP) levels are directly related to increased risk of coronary disease and diabetes. However, data on the association between physical fitness and CRP are sparse...

..However, few data are available on the prognostic implications of reactive (precapillary) PH superimposed on passive (postcapillary) PH...

..Finally, new therapies for the treatment of heart failure complications, such as pulmonary hypertension and anemia, are discussed...

..The purpose of this study was to assess the physiologic significance of coronary artery lesions with an integrated single-photon emission computed tomography (SPECT) and computed tomography coronary angiography (CTCA) device...

..For example, hyperglycemia-induced oxidative stress promotes both the formation of advanced glycosylation end products and PKC activation...

..Sleep-disordered breathing (SDB) has been associated with various benign cardiac arrhythmias occurring during sleep...

..The contribution of coronary angiography should be considered in interpreting the significance of the systemic inflammatory response observed after PCI...

..These studies have presented a compelling argument that diabetic individuals homozygous for the Hp 1 allele are at decreased risk of vascular complications as compared to diabetic individuals with the Hp 2 allele...

..We present a novel approach for the modification of the myocardial electrophysiological substrate using cell grafts genetically engineered to express specific ionic channels...

..Thus, Doppler echocardiography can provide objective noninvasive evidence of abnormal LV filling in a large proportion of patients with HF and preserved LVEF...

..Together with previous studies, our findings suggest that indexes of overall HRV provide useful prognostic information in the full spectrum of CHF severity...

..375; p < 0.005). Most patients (83%) had ≥ 2 risk factors; half of them had ≥ 3 risk factors. We concluded that these at-risk children should be carefully screened for all known risk factors...

..The goal of this study was to determine whether the haptoglobin (Hp) genotype was predictive of restenosis and major adverse cardiac events (MACEs) after percutaneous transluminal coronary angioplasty (PTCA) in individuals with diabetes...

..Dobutamine and possibly high-dose nesiritide can potentially lead to further deterioration of autonomic dysregulation...

..This review article provides an overview on the potential use of inflammatory markers in the context of coronary interventions...

..Worsening renal function (WRF) is an ominous complication in patients with acute heart failure syndrome (AHFS). Few data are available with regard to the clinical implications of transient versus persistent WRF in this setting...

..The aim of the present study was to assess prospectively the correlation and bias between 16-slice MDCT coronary angiography and quantitative coronary angiography analysis (QCA) in these patients...

..There has not been a direct comparison between eptifibatide and abciximab in the rates of major adverse cardiac events, major complications and thrombocytopenia...

..Further understanding of the mechanisms involved in the protection conferred by the patient's sex would advance our understanding about arrhythmias in heart failure...

..These results suggest that cardiac K(ATP) channel activation may be involved in the genesis of ventricular arrhythmias in CHF...

..Thus, accumulation of AGEs in vessel wall provides a common mechanism for the high restenosis rates of patients with diabetes and renal failure...

..We evaluated the ability of human embryonic stem cells (hESCs) and their cardiomyocyte derivatives (hESC-CMs) to engraft and improve myocardial performance in the rat chronic infarction model...

..The study aim was to determine the prevalence and clinical and echocardiographic characteristics of non-myxomatous versus myxomatous flail mitral valve...

..This effect of beta-blockers may play an important protective role by preventing serious ventricular arrhythmias during transient increases in sympathetic activity...

..Proarrhythmic effects may account, in part, for the poor outcome associated with increased endothelin-1 levels in patients with decompensated CHF...

..The development of AGEs cross-link breakers may have important role for future therapy of isolated systolic hypertension and diastolic heart failure in these conditions...

..Only further study will continue to unravel the mechanisms at play and optimal therapy in the face of the profoundly virulent atherosclerotic potential that accompanies diabetes mellitus...

..show that aminoguanidine, an inhibitor of protein crosslinking, retards age-related decline in the elastic properties of the left ventricle and arteries. The significance of these findings is discussed in this commentary...

..Patients with congestive heart failure (CHF) have a high prevalence of ventricular ectopy. However, in the setting of CHF, it is not known whether sex-related or age-dependent differences exist in the susceptibility to arrhythmias...

..Similarly, an increase in serum creatinine (>0.5 mg/dl) in the hospital results in a significantly longer length of stay and has an independent effect on long-term mortality...

..There are few published studies and no randomized trial has yet been performed in this specific group of patients...

..DM is common among patients admitted with decompensated HF, and diabetes-related biologic differences contribute to the progression of HF...

..All are being actively investigated and many show significant promise as beneficial therapies in the treatment of heart failure...

..We aimed to explore whether reduced systemic pain perception in response to experimental stimuli and pain related personality variables characterizes painless MI patients...