Doron Aronson

Summary

Affiliation: Technion-Israel Institute of Technology
Country: Israel

Publications

  1. doi request reprint Impact of red blood cell transfusion on clinical outcomes in patients with acute myocardial infarction
    Doron Aronson
    Department of Cardiology, Rambam Medical Center and the Bruce Rappaport Faculty of Medicine, Haifa, Israel
    Am J Cardiol 102:115-9. 2008
  2. doi request reprint The impact of body mass index on clinical outcomes after acute myocardial infarction
    Doron Aronson
    Department of Cardiology, Rambam Medical Center, Technion, Israel Institute of Technology, Haifa, Israel
    Int J Cardiol 145:476-80. 2010
  3. ncbi request reprint Inverse association between pulmonary function and C-reactive protein in apparently healthy subjects
    Doron Aronson
    Department of Cardiology, Rambam Medical Center, POB 9602, Haifa 31096, Israel
    Am J Respir Crit Care Med 174:626-32. 2006
  4. ncbi request reprint Changes in haemoglobin levels during hospital course and long-term outcome after acute myocardial infarction
    Doron Aronson
    Department of Cardiology, Rambam Medical Center, Rappaport Family Faculty of Medicine, Technion, Haifa 31096, Israel
    Eur Heart J 28:1289-96. 2007
  5. ncbi request reprint Impact of platelet glycoprotein IIb/IIIa receptor inhibitors on renal function in patients with ST-segment elevation myocardial infarction treated with primary or rescue percutaneous coronary intervention
    Azriel B Osherov
    Rambam Health Care Campus Cardiology Department, Haifa, Israel
    EuroIntervention 5:604-9. 2009
  6. ncbi request reprint Prognostic importance of hyponatremia in acute ST-elevation myocardial infarction
    Alexander Goldberg
    Department of Cardiology, Rambam Medical Center, Haifa, Israel
    Am J Med 117:242-8. 2004
  7. doi request reprint The impact of transient and persistent acute kidney injury on long-term outcomes after acute myocardial infarction
    Alexander Goldberg
    Department of Cardiology, Sieff Medical Center, Safed, Israel
    Kidney Int 76:900-6. 2009
  8. ncbi request reprint Inhospital and 1-year mortality of patients who develop worsening renal function following acute ST-elevation myocardial infarction
    Alexander Goldberg
    Department of Cardiology, Rambam Medical Center, and Rappaport Medical School, Haifa, Israel
    Am Heart J 150:330-7. 2005
  9. doi request reprint Velocity Vector Imaging: standard tissue-tracking results acquired in normals--the VVI-STRAIN study
    Shemy Carasso
    Rambam Health Care Campus, Haifa, Israel School of Medicine, The Technion, Israel Institute of Technology, Haifa, Israel
    J Am Soc Echocardiogr 25:543-52. 2012
  10. ncbi request reprint Effect of obesity on the relationship between plasma C-reactive protein and coronary artery stenosis in patients with stable angina
    Doron Aronson
    Department of Cardiology, Rambam Medical Center, B Rappaport Faculty of Medicine, Technion Medical School, Haifa, Israel
    Atherosclerosis 185:137-42. 2006

Collaborators

Detail Information

Publications99

  1. doi request reprint Impact of red blood cell transfusion on clinical outcomes in patients with acute myocardial infarction
    Doron Aronson
    Department of Cardiology, Rambam Medical Center and the Bruce Rappaport Faculty of Medicine, Haifa, Israel
    Am J Cardiol 102:115-9. 2008
    ..The increased mortality observed in transfused patients with nadir hemoglobin above 8 g/dL underscores the clinical difficulty of balancing risks and benefits of RBC transfusion in the setting of ACS...
  2. doi request reprint The impact of body mass index on clinical outcomes after acute myocardial infarction
    Doron Aronson
    Department of Cardiology, Rambam Medical Center, Technion, Israel Institute of Technology, Haifa, Israel
    Int J Cardiol 145:476-80. 2010
    ..However, the existence of the obesity paradox in AMI patients remains controversial...
  3. ncbi request reprint Inverse association between pulmonary function and C-reactive protein in apparently healthy subjects
    Doron Aronson
    Department of Cardiology, Rambam Medical Center, POB 9602, Haifa 31096, Israel
    Am J Respir Crit Care Med 174:626-32. 2006
    ..Increased levels of systemic markers of inflammation have been reported in patients with impaired lung function due to obstructive or restrictive lung disease...
  4. ncbi request reprint Changes in haemoglobin levels during hospital course and long-term outcome after acute myocardial infarction
    Doron Aronson
    Department of Cardiology, Rambam Medical Center, Rappaport Family Faculty of Medicine, Technion, Haifa 31096, Israel
    Eur Heart J 28:1289-96. 2007
    ..To study the prevalence and long-term prognostic significance of changes in haemoglobin levels during hospital course in survivors of acute myocardial infarction (AMI)...
  5. ncbi request reprint Impact of platelet glycoprotein IIb/IIIa receptor inhibitors on renal function in patients with ST-segment elevation myocardial infarction treated with primary or rescue percutaneous coronary intervention
    Azriel B Osherov
    Rambam Health Care Campus Cardiology Department, Haifa, Israel
    EuroIntervention 5:604-9. 2009
    ....
  6. ncbi request reprint Prognostic importance of hyponatremia in acute ST-elevation myocardial infarction
    Alexander Goldberg
    Department of Cardiology, Rambam Medical Center, Haifa, Israel
    Am J Med 117:242-8. 2004
    ..To determine the prevalence and prognostic implications of hyponatremia in the setting of acute ST-elevation myocardial infarction...
  7. doi request reprint The impact of transient and persistent acute kidney injury on long-term outcomes after acute myocardial infarction
    Alexander Goldberg
    Department of Cardiology, Sieff Medical Center, Safed, Israel
    Kidney Int 76:900-6. 2009
    ..Our study shows that dynamic changes in renal function during acute myocardial infarction are strongly related to long-term mortality and heart failure...
  8. ncbi request reprint Inhospital and 1-year mortality of patients who develop worsening renal function following acute ST-elevation myocardial infarction
    Alexander Goldberg
    Department of Cardiology, Rambam Medical Center, and Rappaport Medical School, Haifa, Israel
    Am Heart J 150:330-7. 2005
    ..However, the prevalence and prognostic significance of worsening renal function (WRF) in patients with acute ST-elevation myocardial infarction are unknown...
  9. doi request reprint Velocity Vector Imaging: standard tissue-tracking results acquired in normals--the VVI-STRAIN study
    Shemy Carasso
    Rambam Health Care Campus, Haifa, Israel School of Medicine, The Technion, Israel Institute of Technology, Haifa, Israel
    J Am Soc Echocardiogr 25:543-52. 2012
    ..Different software algorithms have at times yielded conflicting results. The aim of this study was to determine normal myocardial mechanical parameters in a healthy population using Velocity Vector Imaging...
  10. ncbi request reprint Effect of obesity on the relationship between plasma C-reactive protein and coronary artery stenosis in patients with stable angina
    Doron Aronson
    Department of Cardiology, Rambam Medical Center, B Rappaport Faculty of Medicine, Technion Medical School, Haifa, Israel
    Atherosclerosis 185:137-42. 2006
    ..Obesity is strongly associated with elevated CRP levels, potentially confounding the relationship between CRP and CAD severity...
  11. ncbi request reprint Hyponatremia and long-term mortality in survivors of acute ST-elevation myocardial infarction
    Alexander Goldberg
    Department of Cardiology, Rambam Medical Center and Rappaport Medical School, Haifa, Israel
    Arch Intern Med 166:781-6. 2006
    ..The long-term prognostic value of hyponatremia during the acute phase of infarction is not known...
  12. ncbi request reprint Relation of C-reactive protein and new-onset atrial fibrillation in patients with acute myocardial infarction
    Doron Aronson
    Department of Cardiology, Rambam Medical Center and the Rappaport Family Faculty of Medicine, Technion Medical School, Haifa, Israel
    Am J Cardiol 100:753-7. 2007
    ..In conclusion, in a large cohort of patients with AMI, there was a graded positive association between increased CRP and new-onset AF. Inflammation may contribute to the development of AF in the setting of AMI...
  13. ncbi request reprint Fasting glucose in acute myocardial infarction: incremental value for long-term mortality and relationship with left ventricular systolic function
    Doron Aronson
    Department of Cardiology, Rambam Medical Center, Haifa, Israel
    Diabetes Care 30:960-6. 2007
    ..However, few data are available concerning the long-term prognostic value of elevated fasting glucose during the acute phase of infarction...
  14. ncbi request reprint Excessive respiratory variation in tricuspid regurgitation systolic velocities in patients with severe tricuspid regurgitation
    Diab Mutlak
    Echocardiography Laboratory and Heart Valves Clinic, Department of Cardiology, Rambam Health Care Campus and the Bruce Rappaport Faculty of Medicine, Technion Israel Institute of Technology, P O Box 9602, Haifa 31096, Israel
    Eur Heart J Cardiovasc Imaging 14:957-62. 2013
    ..We tested the hypothesis that excessive respiratory changes in TR velocities are diagnostic of severe TR...
  15. doi request reprint Utility of pulmonary hypertension for the prediction of heart failure following acute myocardial infarction
    Diab Mutlak
    Department of Cardiology, Rambam Medical Center, Haifa, Israel
    Am J Cardiol 109:1254-9. 2012
    ..In AMI, PH at the index admission is a useful marker in unmasking latent subclinical HF and predicting the development of overt HF...
  16. ncbi request reprint The impact of GP IIb/IIIa inhibitors during primary percutaneous coronary intervention in acute myocardial infarction patients
    Shahar Lavi
    Rambam Medical Center, Department of Cardiology, Bat Galim, Haifa, Israel, 31096
    J Invasive Cardiol 17:296-9. 2005
    ..99, CI: 1.29-6.9; p=0.01). Therefore, adjunctive therapy with GP IIbIIIa inhibitors during primary PCI is associated with improved short-term outcomes and one-year survival without an increased risk of bleeding...
  17. ncbi request reprint Haptoglobin polymorphism predicts 30-day mortality and heart failure in patients with diabetes and acute myocardial infarction
    Mahmoud Suleiman
    Technion Faculty of Medicine, Rappaport Building, Bat Galim, Haifa, 31096, Israel
    Diabetes 54:2802-6. 2005
    ..Finally, among patients with diabetes, Hp 1-1 was associated with smaller infarct size. This study demonstrates that in patients with diabetes and AMI, the Hp type is an important determinant of clinical outcome and infarct size...
  18. doi request reprint Relation of myocardial mechanics in severe aortic stenosis to left ventricular ejection fraction and response to aortic valve replacement
    Shemy Carasso
    Department of Cardiology, Rambam Health Care Campus, Haifa, Israel
    Am J Cardiol 107:1052-7. 2011
    ..Compensatory mechanics were lost in patients with severe LV dysfunction. AVR partly reversed these changes in patients with LV dysfunction...
  19. ncbi request reprint Association between elevated liver enzymes and C-reactive protein: possible hepatic contribution to systemic inflammation in the metabolic syndrome
    Arthur Kerner
    Department of Cardiology, Rambam Medical Center and Rappaport Faculty of Medicine, Haifa, Israel
    Arterioscler Thromb Vasc Biol 25:193-7. 2005
    ..The objective of this study was to test whether the frequent association between liver enzyme elevations and various components of the metabolic syndrome is associated with higher C-reactive protein (CRP) levels...
  20. doi request reprint Restrictive left ventricular filling pattern and risk of new-onset atrial fibrillation after acute myocardial infarction
    Doron Aronson
    Department of Cardiology, Rambam Medical Center, and Rappaport Faculty of Medicine and Research Institute, Technion, Israel Institute of Technology, Haifa, Israel
    Am J Cardiol 107:1738-43. 2011
    ..In conclusion, in patients with AMI, presence of advanced diastolic dysfunction was independently associated with new-onset AF, suggesting that increased filling pressures may contribute to the development of AF after AMI...
  21. doi request reprint Direct comparison between coronary computed tomography and invasive angiography for calculation of SYNTAX score
    Arthur Kerner
    Cardiology Department, Rambam Health Care Campus, Haifa, Israel
    EuroIntervention 8:1428-34. 2013
    ..We aimed to test the feasibility of calculating SYNTAX score from coronary computed tomographic angiography (CCTA) compared to from invasive coronary angiography (ICA)...
  22. ncbi request reprint Early inflammation and risk of long-term development of heart failure and mortality in survivors of acute myocardial infarction predictive role of C-reactive protein
    Mahmoud Suleiman
    Department of Cardiology, Rambam Medical Center and the Bruce Rappaport Faculty of Medicine, Haifa, Israel
    J Am Coll Cardiol 47:962-8. 2006
    ..We aimed to study the relationship between C-reactive-protein (CRP), obtained within 12 to 24 h of symptoms onset, and long-term risk of death and heart failure (HF) in survivors of acute myocardial infarction (MI)...
  23. ncbi request reprint Relation of C-reactive protein to coronary collaterals in patients with stable angina pectoris and coronary artery disease
    Arthur Kerner
    Department of Cardiology, Rambam Medical Center, Haifa, Israel
    Am J Cardiol 99:509-12. 2007
    ..15 to 0.75; p = 0.008) for patients in the third CRP tertile (p for trend = 0.008). In conclusion, an inverse graded association exists between CRP and the presence of coronary collaterals in patients with stable angina pectoris...
  24. ncbi request reprint Haptoglobin genotype determines myocardial infarct size in diabetic mice
    Shany Blum
    Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    J Am Coll Cardiol 49:82-7. 2007
    ..We sought to understand the importance of oxidative stress in explaining why the haptoglobin (Hp) genotype determines myocardial infarction (MI) size in diabetes mellitus (DM)...
  25. ncbi request reprint Factor analysis of risk variables associated with low-grade inflammation
    Doron Aronson
    Department of Cardiology, Rambam Medical Center and the Ruth and Bruce Rappaport School of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    Atherosclerosis 200:206-12. 2008
    ..The pathophysiology of low-grade inflammation is complex, and multiple intercorrelated conditions have been associated with elevated CRP...
  26. ncbi request reprint Preprocedural C-reactive protein levels predict myocardial necrosis after successful coronary stenting in patients with stable angina
    Alexander Goldberg
    Department of Cardiology, Rambam Medical Center, Haifa, Israel
    Am Heart J 151:1265-70. 2006
    ..Mechanical factors have been implicated in this complication and the role of systemic inflammation is not known...
  27. doi request reprint Cardiac troponin I elevation in hospitalized patients without acute coronary syndromes
    Miry Blich
    Department of Cardiology, Rambam Medical Center and the Technion Medical School, Haifa, Israel
    Am J Cardiol 101:1384-8. 2008
    ..Most of these patients have an alternative explanation for cardiac troponin increase. Cardiac diagnostic procedures are frequently unhelpful in excluding a non-ACS-related troponin increase...
  28. ncbi request reprint Relation of statin therapy to risk of heart failure after acute myocardial infarction
    Doron Aronson
    Department of Cardiology Rambam Health Care Campus, and Rappaport Medical School, Technion, Haifa, Israel
    Am J Cardiol 102:1706-10. 2008
    ..The effect of statins is driven largely by the reduction in events in patients without concomitant hemodynamically significant MR...
  29. doi request reprint Impact of diastolic dysfunction on the development of heart failure in diabetic patients after acute myocardial infarction
    Doron Aronson
    Department of Cardiology, Rambam Medical Center, Haifa, Israel
    Circ Heart Fail 3:125-31. 2010
    ..However, there are no data regarding the contribution of diastolic dysfunction to the development of heart failure (HF) in diabetic patients after acute myocardial infarction...
  30. doi request reprint Usefulness of changes in fasting glucose during hospitalization to predict long-term mortality in patients with acute myocardial infarction
    Doron Aronson
    Department of Cardiology, Rambam Medical Center, and Bruce Rappaport Faculty of Medicine, Haifa, Israel
    Am J Cardiol 104:1013-7. 2009
    ..Changes in FG during hospitalization are simple and sensitive indicators of dynamic changes in risk...
  31. ncbi request reprint The association between cardiorespiratory fitness and C-reactive protein in subjects with the metabolic syndrome
    Doron Aronson
    Department of Cardiology, Rambam Medical Center and Rappaport Faculty of Medicine, Haifa, Israel
    J Am Coll Cardiol 44:2003-7. 2004
    ..We sought to study relationship between cardiorespiratory fitness and C-reactive protein (CRP) in subjects with the metabolic syndrome...
  32. doi request reprint Multidetector computed tomography predictors of late ventricular remodeling and function after acute myocardial infarction
    Jonathan Lessick
    Cardiology Department, Rambam Health Care Campus, Haaliya Street, Haifa, Israel Technion IIT, Haaliya Street, Haifa, Israel j
    Eur J Radiol 81:2648-57. 2012
    ..We aimed to study the association between multidetector row computed tomography (MDCT) perfusion defects and ventricular remodeling post-AMI...
  33. ncbi request reprint Predictive value of white blood cell subtypes for long-term outcome following myocardial infarction
    Robert Dragu
    Department of Cardiology, Rambam Medical Center, Bruce Rappaport Faculty of Medicine, Haifa, Israel
    Atherosclerosis 196:405-12. 2008
    ..However, it is unknown which specific subset of leukocytes best correlates with increased risk of adverse outcome...
  34. doi request reprint Functional tricuspid regurgitation in patients with pulmonary hypertension: is pulmonary artery pressure the only determinant of regurgitation severity?
    Diab Mutlak
    Department of Cardiology, Echocardiography Laboratory and Heart Valves Clinic, Bruce Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    Chest 135:115-21. 2009
    ..The objectives of our study were to determine the distribution of TR severity in relation to pulmonary artery systolic pressure (PASP) and to define the determinants of TR severity...
  35. doi request reprint Relationship of functional mitral regurgitation to new-onset atrial fibrillation in acute myocardial infarction
    Fadel Bahouth
    Department of Cardiology, Rambam Medical Center, Bat Galim, POB 9602, Haifa 31096, Israel
    Heart 96:683-8. 2010
    ..This study was designed to test the hypothesis that functional mitral regurgitation (FMR) occurring after AMI may promote AF by producing left atrial volume overload...
  36. ncbi request reprint Serum blood urea nitrogen and long-term mortality in acute ST-elevation myocardial infarction
    Doron Aronson
    Department of Cardiology Rambam Medical Center, and Rappaport Medical School, Haifa, Israel
    Int J Cardiol 127:380-5. 2008
    ..Few data are available on the prognostic significance of blood urea nitrogen (BUN), a sensitive marker of hemodynamic alterations and renal perfusion...
  37. doi request reprint Prevalence and prognostic significance of transient, persistent, and new-onset anemia after acute myocardial infarction
    Tal Hasin
    Department of Cardiology, Rambam Medical Center and Bruce Rappaport Faculty of Medicine and Research Institute, Haifa, Israel
    Am J Cardiol 104:486-91. 2009
    ..Whereas the resolution of anemia after AMI is associated with better outcomes, persistent or new-onset anemia portends increased risk for heart failure and death...
  38. ncbi request reprint Pulmonary hypertension, right ventricular function, and clinical outcome in acute decompensated heart failure
    Doron Aronson
    Department of Cardiology, Rambam Medical Center and The Ruth and Bruce Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel Electronic address
    J Card Fail 19:665-71. 2013
    ..However, data are lacking in the setting of acute decompensated heart failure (ADHF). We sought to determine prognostic significance of PH in patients with ADHF and its interaction with RV function...
  39. ncbi request reprint Procalcitonin and interleukin 6 for predicting blood culture positivity in sepsis
    Mohammad Naffaa
    Department of Internal Medicine B, Rambam Health Care Campus, Haifa, Israel Ruth and Bruce Rappaport Faculty of Medicine, Technion, Israel Institute of Technology, Haifa, Israel
    Am J Emerg Med 32:448-51. 2014
    ..This study aims to examine and compare the performance of procalcitonin and IL-6, measured concomitantly, in predicting blood culture positivity in patients with sepsis...
  40. ncbi request reprint Chest pain unit in an internal medicine department: comparison of a year with the facility to a year without
    Shadi Hamoud
    Department of Internal Medicine E, Rambam Health Care Campus, Haifa, Israel
    Isr Med Assoc J 15:79-84. 2013
    ..Chest pain units (CPU) are being incorporated in tertiary hospitals for rapid and effective management of patients with chest pain. In Israel prior to 2010, only one chest pain unit existed in a tertiary hospital...
  41. doi request reprint Relation between red cell distribution width and clinical outcomes after acute myocardial infarction
    Saleem Dabbah
    Department of Cardiology, Rambam Medical Center, and the Bruce Rappaport Faculty of Medicine and Research Institute, Technion, Israel Institute of Technology, Haifa, Israel
    Am J Cardiol 105:312-7. 2010
    ..In conclusion, there is a graded, independent association between increased RDW and mortality after AMI. An increase in RDW during hospitalization also portends adverse clinical outcome...
  42. ncbi request reprint Admission C-reactive protein levels and 30-day mortality in patients with acute myocardial infarction
    Mahmoud Suleiman
    Department of Cardiology, Rambam Medical Center and the Bruce Rappaport Faculty of Medicine, Haifa, Israel
    Am J Med 115:695-701. 2003
    ..However, limited information is available concerning the value of C-reactive protein levels in patients with acute myocardial infarction...
  43. ncbi request reprint Frequency, characteristics, and outcome of patients with aortic stenosis, left ventricular dysfunction, and high (versus low) trans-aortic pressure gradient
    Diab Mutlak
    Echocardiography Laboratory and Heart Valves Clinic, Department of Cardiology, Rambam Health Care Campus, affiliated with Rappaport Faculty of Medicine, Technion lsrael Institute of Technology, Haifa, Israel
    Isr Med Assoc J 12:563-7. 2010
    ..Trans-aortic pressure gradient in patients with aortic stenosis and left ventricular systolic dysfunction is typically low but occasionally high...
  44. doi request reprint Incidence of early left ventricular thrombus after acute anterior wall myocardial infarction in the primary coronary intervention era
    Azriel B Osherov
    Faculty of Medicine, Department of Cardiology, Rambam Medical Center, B Rappaport, Technion Israel Institute of Technology Haifa, Israel
    Am Heart J 157:1074-80. 2009
    ..We sought to demonstrate the incidence of LVT after AMI in patients treated with PPCI compared with those treated with thrombolysis or with conservative management...
  45. ncbi request reprint Ischemic mitral regurgitation and risk of heart failure after myocardial infarction
    Doron Aronson
    Department of Cardiology, Rambam Medical Center and Rappaport Medical School, Haifa, Israel
    Arch Intern Med 166:2362-8. 2006
    ..However, few data are available on the relationship between ischemic MR and the long-term risk for HF...
  46. ncbi request reprint Elevated blood urea nitrogen level as a predictor of mortality in patients admitted for decompensated heart failure
    Doron Aronson
    Division of Cardiology, Rambam Medical Center, Haifa, Israel
    Am J Med 116:466-73. 2004
    ..In heart failure, renal function involves both cardiovascular and hemodynamic properties. We studied the relation between renal dysfunction and mortality in patients admitted for decompensated heart failure...
  47. ncbi request reprint Five-year clinical follow up after intracoronary radiation for the prevention of in-stent restenosis
    Luis Gruberg
    Division of Invasive Cardiology, Rambam Medical Center and the Bruce Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    J Invasive Cardiol 18:494-8. 2006
    ..6 +/- 15 months. Therefore, during long-term follow up following IRT for the prevention of ISR, half of all patients developed a major cardiovascular event, mainly due to the need for repeat revascularization procedures...
  48. ncbi request reprint Retinal capillary basement membrane thickness in diabetic mice genetically modified at the haptoglobin locus
    Rachel Miller-Lotan
    Technion Israel Institute of Technology, Haifa, Israel
    Diabetes Metab Res Rev 23:152-6. 2007
    ..We sought to recapitulate these findings in DM mice genetically modified at the Hp locus...
  49. ncbi request reprint Impact of functional mitral regurgitation on right ventricular function and outcome in patients with right ventricular infarction
    Sergey Yalonetsky
    Department of Cardiology, Rambam Medical Center, Haifa, Israel The Ruth and Bruce Rappaport Faculty of Medicine, Technion, Israel Institute of Technology, Haifa, Israel
    Am J Cardiol 114:36-41. 2014
    ..The risk for mortality is increased predominantly in patients with both RV dysfunction and FMR. ..
  50. doi request reprint Frequency, determinants and outcome of pulmonary hypertension in patients with aortic valve stenosis
    Diab Mutlak
    Echocardiography Laboratory and Heart Valves Clinic, Department of Cardiology, Rambam Health Care Campus, Haifa, Israel
    Am J Med Sci 343:397-401. 2012
    ....
  51. ncbi request reprint Fasting glucose is an important independent risk factor for 30-day mortality in patients with acute myocardial infarction: a prospective study
    Mahmoud Suleiman
    Department of Cardiology, Rambam Medical Center, and the Bruce Rappaport Faculty of Medicine, Haifa, Israel
    Circulation 111:754-60. 2005
    ..Most studies looked at the relationship between admission glucose (AG) and outcome; limited information is available about the clinical significance of fasting glucose (FG)...
  52. ncbi request reprint Vitamin E supplementation reduces cardiovascular events in a subgroup of middle-aged individuals with both type 2 diabetes mellitus and the haptoglobin 2-2 genotype: a prospective double-blinded clinical trial
    Uzi Milman
    Clalit Health Services, Haifa, Israel
    Arterioscler Thromb Vasc Biol 28:341-7. 2008
    ..We sought to test the hypothesis that vitamin E could reduce cardiovascular events in DM individuals with the Hp 2-2 genotype, a subgroup that comprises 2% to 3% of the general population...
  53. ncbi request reprint A combined cell therapy and in-situ tissue-engineering approach for myocardial repair
    Manhal Habib
    Bruce Rappaport Faculty of Medicine and Technion Israel Institute of Technology, Haifa, Israel
    Biomaterials 32:7514-23. 2011
    ..We conclude that an injectable in-situ forming hydrogel can act as a cardiomyocyte cell-carrier and add to the beneficial effects of the grafted cells in preventing unfavorable post-infarction cardiac remodeling...
  54. doi request reprint Integrated SPECT/CT for assessment of haemodynamically significant coronary artery lesions in patients with acute coronary syndrome
    Shmuel Rispler
    Department of Cardiology, Rambam Health Care Campus and the B Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    Eur J Nucl Med Mol Imaging 38:1917-25. 2011
    ..In the present study we assessed whether hybrid single photon emission computed tomography (SPECT)/coronary computed tomography angiography (CCTA) technology could be an appropriate tool in stratifying patients with NSTE-ACS...
  55. doi request reprint Interleukin-6 at discharge predicts all-cause mortality in patients with sepsis
    Mohammad Naffaa
    Department of Internal Medicine B, Rambam Health Care Campus, Haifa, Israel
    Am J Emerg Med 31:1361-4. 2013
    ..Interleukin-6 (IL-6) is a proinflammatory cytokine that plays a central role in the pathogenesis of sepsis. We aim to investigate the association between IL-6 and all-cause mortality in patients with sepsis...
  56. pmc The relation between serum phosphorus levels and clinical outcomes after acute myocardial infarction
    Doron Aronson
    Department of Cardiology, Rambam Medical Center, Haifa, Israel
    PLoS ONE 8:e58348. 2013
    ..Elevated serum phosphorus levels have been linked with cardiovascular disease and mortality with conflicting results, especially in the presence of normal renal function...
  57. pmc Macrophage activation by heparanase is mediated by TLR-2 and TLR-4 and associates with plaque progression
    Miry Blich
    Department of Cardiology and Pathology, Rambam Health Care Campus, Haifa, Israel
    Arterioscler Thromb Vasc Biol 33:e56-65. 2013
    ..Factors and mechanisms that activate macrophages in atherosclerotic plaques are incompletely understood. We examined the capacity of heparanase to activate macrophages...
  58. doi request reprint Relationship between reactive pulmonary hypertension and mortality in patients with acute decompensated heart failure
    Doron Aronson
    Department of Cardiology, Rambam Medical Center, Haifa, Israel
    Circ Heart Fail 4:644-50. 2011
    ..However, few data are available on the prognostic implications of reactive (precapillary) PH superimposed on passive (postcapillary) PH...
  59. ncbi request reprint C-Reactive protein is inversely related to physical fitness in middle-aged subjects
    Doron Aronson
    Department of Cardiology, Rambam Medical Center and Rappaport Faculty of Medicine, POB 9602, Haifa 31096, Israel
    Atherosclerosis 176:173-9. 2004
    ..C-reactive protein (CRP) levels are directly related to increased risk of coronary disease and diabetes. However, data on the association between physical fitness and CRP are sparse...
  60. ncbi request reprint Relation between pulse pressure and survival in patients with decompensated heart failure
    Doron Aronson
    Division of Cardiology, Rambam Medical Center, Haifa, Israel
    Am J Cardiol 93:785-8. 2004
    ..We found that the association of PP with outcome in this setting is reversed, with low PP being an independent predictor of mortality...
  61. ncbi request reprint Echocardiography-based spectrum of severe tricuspid regurgitation: the frequency of apparently idiopathic tricuspid regurgitation
    Diab Mutlak
    Echocardiography Laboratory and Heart Valves Clinic, Department of Cardiology, Rambam Health Care Campus and the Bruce Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    J Am Soc Echocardiogr 20:405-8. 2007
    ....
  62. doi request reprint Fluid loss, venous congestion, and worsening renal function in acute decompensated heart failure
    Doron Aronson
    Department of Cardiology, Rambam Medical Center, and the Rappaport Faculty of Medicine, Technion, Israel Institute of Technology, Haifa, Israel
    Eur J Heart Fail 15:637-43. 2013
    ..To investigate the relationship between decongestion, central venous pressure, and risk of worsening renal function (WRF) in patients with acute decompensated heart failure (ADHF)...
  63. doi request reprint Phosphodiesterase-5 inhibition attenuates early renal ischemia-reperfusion-induced acute kidney injury: assessment by quantitative measurement of urinary NGAL and KIM-1
    Rima Sohotnik
    Department of Nephrology and Hypertension, Carmel Medical Center, Haifa, Israel
    Am J Physiol Renal Physiol 304:F1099-104. 2013
    ..These findings demonstrate that Tadalafil possesses early nephroprotective effects in rat kidneys subjected to I/R insult. This approach may suggest a prophylactic therapy for patients with ischemic AKI...
  64. doi request reprint Endothelial progenitor cells in acute myocardial infarction and sleep-disordered breathing
    Slava Berger
    The Lloyd Rigler Sleep Apnea Research Laboratory, Unit of Anatomy and Cell Biology, The Ruth and Bruce Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    Am J Respir Crit Care Med 187:90-8. 2013
    ..Mobilization and functions of endothelial progenitor cells (EPCs) are increased in patients with acute myocardial infarction (AMI). Yet, sleep-disordered breathing (SDB) is highly prevalent in patients with AMI...
  65. doi request reprint Novel therapies in acute and chronic heart failure
    Doron Aronson
    Division of Cardiology, Rambam Medical Center, Haifa, Israel
    Pharmacol Ther 135:1-17. 2012
    ..Finally, new therapies for the treatment of heart failure complications, such as pulmonary hypertension and anemia, are discussed...
  66. ncbi request reprint Integrated single-photon emission computed tomography and computed tomography coronary angiography for the assessment of hemodynamically significant coronary artery lesions
    Shmuel Rispler
    Department of Cardiology, Technion Israel Institute of Technology, Haifa, Israel
    J Am Coll Cardiol 49:1059-67. 2007
    ..The purpose of this study was to assess the physiologic significance of coronary artery lesions with an integrated single-photon emission computed tomography (SPECT) and computed tomography coronary angiography (CTCA) device...
  67. doi request reprint Circadian pattern of life-threatening ventricular arrhythmia in patients with sleep-disordered breathing and implantable cardioverter-defibrillators
    Tawfiq Zeidan-Shwiri
    Department of Cardiology, Rambam Medical Center, Haifa, Israel
    Heart Rhythm 8:657-62. 2011
    ..Sleep-disordered breathing (SDB) has been associated with various benign cardiac arrhythmias occurring during sleep...
  68. doi request reprint Hyperglycemia and the pathobiology of diabetic complications
    Doron Aronson
    Department of Cardiology, Rambam Medical Center, Haifa, Israel
    Adv Cardiol 45:1-16. 2008
    ..For example, hyperglycemia-induced oxidative stress promotes both the formation of advanced glycosylation end products and PKC activation...
  69. ncbi request reprint Diagnostic coronary angiography induces a systemic inflammatory response in patients with stable angina
    Alexander Goldberg
    Department of Cardiology, Rambam Medical Center and Rappaport Medical School, Haifa, Israel
    Am Heart J 146:819-23. 2003
    ..The aim of this study was the determine whether diagnostic coronary angiography performed in patients with stable angina triggers a systemic inflammatory response...
  70. doi request reprint Cell therapy for modification of the myocardial electrophysiological substrate
    Lior Yankelson
    Sohnis Laboratory for Cardiac Electrophysiology and Regenerative Medicine, Bruce Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    Circulation 117:720-31. 2008
    ..We present a novel approach for the modification of the myocardial electrophysiological substrate using cell grafts genetically engineered to express specific ionic channels...
  71. ncbi request reprint Measures of heart period variability as predictors of mortality in hospitalized patients with decompensated congestive heart failure
    Doron Aronson
    Division of Cardiology, Rambam Medical Center, Haifa, Israel
    Am J Cardiol 93:59-63. 2004
    ..Together with previous studies, our findings suggest that indexes of overall HRV provide useful prognostic information in the full spectrum of CHF severity...
  72. ncbi request reprint Increased renal hypertrophy in diabetic mice genetically modified at the haptoglobin locus
    Rachel Miller-Lotan
    Technion Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    Diabetes Metab Res Rev 21:332-7. 2005
    ..These studies have presented a compelling argument that diabetic individuals homozygous for the Hp 1 allele are at decreased risk of vascular complications as compared to diabetic individuals with the Hp 2 allele...
  73. ncbi request reprint Serum chelatable redox-active iron is an independent predictor of mortality after myocardial infarction in individuals with diabetes
    Mahmoud Sulieman
    Department of Cardiology, Rambam Medical Center, Haifa, Israel
    Diabetes Care 27:2730-2. 2004
  74. ncbi request reprint Left ventricular filling hemodynamics in patients with pulmonary edema and preserved versus reduced left ventricular ejection fraction: a prospective Doppler echocardiographic study
    Salim Dabbah
    Department of Cardiology, Rambam Medical Center, Haifa, Israel
    J Am Soc Echocardiogr 19:733-43. 2006
    ..The objective of this study was to examine whether elevated LV filling pressures can be demonstrated noninvasively in consecutive patients with HF and preserved (vs reduced) LVEF...
  75. ncbi request reprint Effect of nesiritide (human b-type natriuretic peptide) and dobutamine on heart rate variability in decompensated heart failure
    Doron Aronson
    Division of Cardiology, Rambam Medical Center, Haifa, Israel
    Am Heart J 148:e16. 2004
    ..We sought to assess the effects of nesiritide compared with dobutamine on time-domain indices of heart rate variability (HRV) in patients with decompensated CHF...
  76. doi request reprint The relationship between transient and persistent worsening renal function and mortality in patients with acute decompensated heart failure
    Doron Aronson
    Department of Cardiology, Rambam Medical Center, Haifa, Israel
    J Card Fail 16:541-7. 2010
    ..Worsening renal function (WRF) is an ominous complication in patients with acute heart failure syndrome (AHFS). Few data are available with regard to the clinical implications of transient versus persistent WRF in this setting...
  77. doi request reprint Cross-sectional analysis of cardiovascular risk factors in children with parental history of premature ischemic heart disease
    Gal Neuman
    Department of Pediatrics, Meyer Children s Hospital, Rambam Health Care Campus, Haifa, Israel
    Pediatr Cardiol 32:628-33. 2011
    ..375; p < 0.005). Most patients (83%) had ≥ 2 risk factors; half of them had ≥ 3 risk factors. We concluded that these at-risk children should be carefully screened for all known risk factors...
  78. ncbi request reprint Inflammatory markers: linking unstable plaques to coronary event, an interventional perspective
    Doron Aronson
    Department of Cardiology, Rambam Medical Center, Haifa, Israel
    Int J Cardiovasc Intervent 6:110-8. 2004
    ..This review article provides an overview on the potential use of inflammatory markers in the context of coronary interventions...
  79. ncbi request reprint Haptoglobin genotype is predictive of major adverse cardiac events in the 1-year period after percutaneous transluminal coronary angioplasty in individuals with diabetes
    Ariel Roguin
    Technion Israel Institute of Technology, Haifa, Israel
    Diabetes Care 26:2628-31. 2003
    ..The goal of this study was to determine whether the haptoglobin (Hp) genotype was predictive of restenosis and major adverse cardiac events (MACEs) after percutaneous transluminal coronary angioplasty (PTCA) in individuals with diabetes...
  80. ncbi request reprint Contrast enhanced multi-detector computed tomography coronary angiography versus conventional invasive quantitative coronary angiography in acute coronary syndrome patients-correlation and bias
    Robert Dragu
    Division of Invasive Cardiology, Rambam Health Care Campus and the Bruce Rappaport Faculty of Medicine, The Technion Isreal Institute of Technology, Haifa, Isreal
    Acute Card Care 8:99-104. 2006
    ..The aim of the present study was to assess prospectively the correlation and bias between 16-slice MDCT coronary angiography and quantitative coronary angiography analysis (QCA) in these patients...
  81. ncbi request reprint Comparison of two platelet glycoprotein IIb/IIIa inhibitors, eptifibatide and abciximab: outcomes, complications and thrombocytopenia during percutaneous coronary intervention
    Mahmoud Suleiman
    Division of Invasive Cardiology, Department of Cardiology, Rambam Medical Center, Haifa 31096, Israel
    J Invasive Cardiol 15:319-23. 2003
    ..There has not been a direct comparison between eptifibatide and abciximab in the rates of major adverse cardiac events, major complications and thrombocytopenia...
  82. ncbi request reprint Effects of sulfonylurea hypoglycemic agents and adenosine triphosphate dependent potassium channel antagonists on ventricular arrhythmias in patients with decompensated heart failure
    Doron Aronson
    Division of Cardiology, Rambam Medical Center, Haifa, Israel
    Pacing Clin Electrophysiol 26:1254-61. 2003
    ..These results suggest that cardiac K(ATP) channel activation may be involved in the genesis of ventricular arrhythmias in CHF...
  83. ncbi request reprint The effect of sex on ventricular arrhythmic events in patients with congestive heart failure
    Doron Aronson
    Cardiology Division, Rambam Medical Center, Haifa, Israel
    Pacing Clin Electrophysiol 25:1206-11. 2002
    ..Further understanding of the mechanisms involved in the protection conferred by the patient's sex would advance our understanding about arrhythmias in heart failure...
  84. pmc Revascularization for coronary artery disease in diabetes mellitus: angioplasty, stents and coronary artery bypass grafting
    Doron Aronson
    Department of Cardiology, Rambam Medical Center and the Rappaport Research Institute, Technion, Israel Institute of Technology, Haifa, Israel
    Rev Endocr Metab Disord 11:75-86. 2010
    ..Only further study will continue to unravel the mechanisms at play and optimal therapy in the face of the profoundly virulent atherosclerotic potential that accompanies diabetes mellitus...
  85. ncbi request reprint Non-myxomatous flail mitral valve: clinical and echocardiographic characteristics and long-term clinical outcome
    Salim Adawil
    Department of Cardiovascular Medicine, Lady Davis Carmel Medical Center, Haifa, Israel
    J Heart Valve Dis 16:336-43. 2007
    ..The study aim was to determine the prevalence and clinical and echocardiographic characteristics of non-myxomatous versus myxomatous flail mitral valve...
  86. ncbi request reprint Cross-linking of glycated collagen in the pathogenesis of arterial and myocardial stiffening of aging and diabetes
    Doron Aronson
    Department of Cardiology, Rambam Medical Center, POB 9602, Haifa 31096, Israel
    J Hypertens 21:3-12. 2003
    ..The development of AGEs cross-link breakers may have important role for future therapy of isolated systolic hypertension and diastolic heart failure in these conditions...
  87. ncbi request reprint Potential role of advanced glycosylation end products in promoting restenosis in diabetes and renal failure
    Doron Aronson
    Department of Cardiology, Rambam Medical Center, Haifa, Israel
    Med Hypotheses 59:297-301. 2002
    ..Thus, accumulation of AGEs in vessel wall provides a common mechanism for the high restenosis rates of patients with diabetes and renal failure...
  88. ncbi request reprint Transplantation of human embryonic stem cell-derived cardiomyocytes improves myocardial performance in infarcted rat hearts
    Oren Caspi
    Sohnis Family Research Laboratory for Cardiac Electrophysiology and Regenerative Medicine, The Rappaport Family Institute for Research in the Medical Sciences, Technion Israel Institute of Technology, Haifa, Israel
    J Am Coll Cardiol 50:1884-93. 2007
    ..We evaluated the ability of human embryonic stem cells (hESCs) and their cardiomyocyte derivatives (hESC-CMs) to engraft and improve myocardial performance in the rat chronic infarction model...
  89. ncbi request reprint Neurohumoral activation and ventricular arrhythmias in patients with decompensated congestive heart failure: role of endothelin
    Doron Aronson
    Cardiology Division, Rambam Medical Center, Haifa, Israel
    Pacing Clin Electrophysiol 26:703-10. 2003
    ..Proarrhythmic effects may account, in part, for the poor outcome associated with increased endothelin-1 levels in patients with decompensated CHF...
  90. ncbi request reprint Concomitant beta-blocker therapy is associated with a lower occurrence of ventricular arrhythmias in patients with decompensated heart failure
    Doron Aronson
    Division of Cardiology, Rambam Medical Center, Haifa, Israel
    J Card Fail 8:79-85. 2002
    ..However, supporting data in patients with CHF are sparse, especially in the setting of excessive neurohumoral activation associated with symptomatic decompensated heart failure...
  91. pmc Pharmacological prevention of cardiovascular aging--targeting the Maillard reaction
    Doron Aronson
    Department of Cardiology, Rambam Medical Center, POB 9602, Haifa 31096, Israel
    Br J Pharmacol 142:1055-8. 2004
    ..show that aminoguanidine, an inhibitor of protein crosslinking, retards age-related decline in the elastic properties of the left ventricle and arteries. The significance of these findings is discussed in this commentary...
  92. ncbi request reprint Age and sex as determinants of ventricular arrhythmic events in patients with decompensated congestive heart failure
    Andrew J Burger
    Beth Israel Deaconess Medical Center, Noninvasive Cardiology Laboratory, Boston, Massachusetts 02215, USA
    Ann Noninvasive Electrocardiol 7:234-41. 2002
    ..Patients with congestive heart failure (CHF) have a high prevalence of ventricular ectopy. However, in the setting of CHF, it is not known whether sex-related or age-dependent differences exist in the susceptibility to arrhythmias...
  93. ncbi request reprint Effect of elevated admission serum creatinine and its worsening on outcome in hospitalized patients with decompensated heart failure
    Mohammed W Akhter
    Heart Failure Program, Division of Cardiovascular Medicine, University of Southern California, Keck School of Medicine, Los Angeles, California 90033, USA
    Am J Cardiol 94:957-60. 2004
    ..Similarly, an increase in serum creatinine (>0.5 mg/dl) in the hospital results in a significantly longer length of stay and has an independent effect on long-term mortality...
  94. ncbi request reprint Haptoglobin type and 30-day mortality in diabetic individuals presenting with acute myocardial infarction
    Mahmoud Suleiman
    Diabetes Care 26:2699-700. 2003
  95. ncbi request reprint Prognosis assessment in patients with decompensated heart failure. Simple clinical parameters or neurohormonal factors
    Doron Aronson
    Ital Heart J 5:494-7. 2004
  96. ncbi request reprint Primary percutaneous coronary intervention after out-of-hospital cardiac arrest: patients and outcomes
    Erez Marcusohn
    Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
    Isr Med Assoc J 9:257-9. 2007
    ..There are few published studies and no randomized trial has yet been performed in this specific group of patients...
  97. ncbi request reprint Prognostic impact of diabetes mellitus in patients with acute decompensated heart failure
    Andrew J Burger
    Beth Israel Deaconess Medical Center, Noninvasive Cardiology Laboratory, Boston, Massachusetts 02215, USA
    Am J Cardiol 95:1117-9. 2005
    ..DM is common among patients admitted with decompensated HF, and diabetes-related biologic differences contribute to the progression of HF...
  98. ncbi request reprint Clinical and experimental pain perception is attenuated in patients with painless myocardial infarction
    Michal Granot
    Faculty of Social Welfare and Health Studies, University of Haifa, Israel
    Pain 133:120-7. 2007
    ..We aimed to explore whether reduced systemic pain perception in response to experimental stimuli and pain related personality variables characterizes painless MI patients...
  99. ncbi request reprint New therapies for the treatment of congestive heart failure
    Andrew J Burger
    Division of Cardiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston Massachusetts 02215, USA
    Drugs Today (Barc) 38:31-48. 2002
    ..All are being actively investigated and many show significant promise as beneficial therapies in the treatment of heart failure...