Dalia Somjen

Summary

Country: Israel

Publications

  1. ncbi request reprint A synthetic peptide with estrogen-like activity derived from a phage-display peptide library
    Natarajan Venkatesh
    Departments of Biological Chemistry, The Weizmann Institute of Science, 76100, Rehovot, Israel
    Peptides 23:573-80. 2002
  2. ncbi request reprint Estrogenic activity of glabridin and glabrene from licorice roots on human osteoblasts and prepubertal rat skeletal tissues
    Dalia Somjen
    Institute of Endocrinology, Metabolism and Hypertension, Tel Aviv Sourasky Medical Center and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 64239, Israel
    J Steroid Biochem Mol Biol 91:241-6. 2004
  3. ncbi request reprint Diabetes modulates differentially creatine kinase-specific activity responsiveness to estradiol-17beta and to raloxifene in rat organs
    Dalia Somjen
    Institute of Endocrinology, Metabolism and Hypertension, Tel Aviv Sourasky Medical Center and the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 64239, Israel
    J Cell Biochem 99:133-9. 2006
  4. ncbi request reprint DT56a (Femarelle): a natural selective estrogen receptor modulator (SERM)
    Dalia Somjen
    Institute of Endocrinology, Metabolism and Hypertension, Sourasky Medical Center, Tel Aviv, Israel
    J Steroid Biochem Mol Biol 104:252-8. 2007
  5. pmc Nuclear vitamin D receptor expression is associated with improved survival in non-small cell lung cancer
    Malini Srinivasan
    Department of Epidemiology, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA 15261, USA
    J Steroid Biochem Mol Biol 123:30-6. 2011
  6. doi request reprint New vitamin D less-calcemic analog affect human bone cell line and cultured vascular smooth muscle cells similar to other less-calcemic analogs
    D Somjen
    Institute of Endocrinology, Metabolism and Hypertension, Tel Aviv Sourasky Medical Center and the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel Electronic address
    J Steroid Biochem Mol Biol 140:1-6. 2014
  7. doi request reprint Vitamin D less-calcemic analog modulates the expression of estrogen receptors, vitamin D receptor and 1α-hydroxylase 25-hydroxy vitamin D in human thyroid cancer cell lines
    D Somjen
    Institute of Endocrinology, Metabolism and Hypertension, Tel Aviv Sourasky Medical Centre and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    J Steroid Biochem Mol Biol 136:80-2. 2013
  8. ncbi request reprint Age-dependent responsiveness of human female bone cells to vitamin D analog and PTH
    D Somjen
    Institute of Endocrinology, Metabolism and Hypertension, Tel Aviv Sourasky Medical Centre and The Sackler Faculty of Medicine Tel Aviv University, Tel Aviv 64239, Israel
    J Endocrinol Invest 36:118-22. 2013
  9. doi request reprint Rivaroxaban, a direct inhibitor of the coagulation factor Xa interferes with hormonal-induced physiological modulations in human female osteoblastic cell line SaSO2
    Dalia Somjen
    Institute of Endocrinology, Metabolism and Hypertension, Tel Aviv Sourasky Medical Center and the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 64239, Israel
    J Steroid Biochem Mol Biol 135:67-70. 2013
  10. ncbi request reprint 25 hydroxy-vitamin D(3)-1alpha hydroxylase expression and activity in cultured human osteoblasts and their modulation by parathyroid hormone, estrogenic compounds and dihydrotestosterone
    Dalia Somjen
    Institute of Endocrinology, Metabolism and Hypertension, Tel Aviv University, Tel Aviv, Israel
    J Steroid Biochem Mol Biol 107:238-44. 2007

Collaborators

Detail Information

Publications46

  1. ncbi request reprint A synthetic peptide with estrogen-like activity derived from a phage-display peptide library
    Natarajan Venkatesh
    Departments of Biological Chemistry, The Weizmann Institute of Science, 76100, Rehovot, Israel
    Peptides 23:573-80. 2002
    ..This approach can be employed to design peptide mimetic for other hormones as well...
  2. ncbi request reprint Estrogenic activity of glabridin and glabrene from licorice roots on human osteoblasts and prepubertal rat skeletal tissues
    Dalia Somjen
    Institute of Endocrinology, Metabolism and Hypertension, Tel Aviv Sourasky Medical Center and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 64239, Israel
    J Steroid Biochem Mol Biol 91:241-6. 2004
    ..Glabrene activity was not inhibited by raloxifene. Therefore, glabridin shows greater similarity to estradiol-17beta and thus greater potential, with or without Vitamin D, to modulate bone disorders in post-menopausal women...
  3. ncbi request reprint Diabetes modulates differentially creatine kinase-specific activity responsiveness to estradiol-17beta and to raloxifene in rat organs
    Dalia Somjen
    Institute of Endocrinology, Metabolism and Hypertension, Tel Aviv Sourasky Medical Center and the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 64239, Israel
    J Cell Biochem 99:133-9. 2006
    ..The decreased response to E2 detected in organs derived from diabetic rats might be due to changes in nuclear and/or membrane estrogen receptors and/or other genomic and non-genomic pathways, as was shown in in vitro cellular models...
  4. ncbi request reprint DT56a (Femarelle): a natural selective estrogen receptor modulator (SERM)
    Dalia Somjen
    Institute of Endocrinology, Metabolism and Hypertension, Sourasky Medical Center, Tel Aviv, Israel
    J Steroid Biochem Mol Biol 104:252-8. 2007
    ..Further investigations regarding intra and extra cellular mechanism of action of DT56a are currently performed...
  5. pmc Nuclear vitamin D receptor expression is associated with improved survival in non-small cell lung cancer
    Malini Srinivasan
    Department of Epidemiology, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA 15261, USA
    J Steroid Biochem Mol Biol 123:30-6. 2011
    ....
  6. doi request reprint New vitamin D less-calcemic analog affect human bone cell line and cultured vascular smooth muscle cells similar to other less-calcemic analogs
    D Somjen
    Institute of Endocrinology, Metabolism and Hypertension, Tel Aviv Sourasky Medical Center and the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel Electronic address
    J Steroid Biochem Mol Biol 140:1-6. 2014
    ....
  7. doi request reprint Vitamin D less-calcemic analog modulates the expression of estrogen receptors, vitamin D receptor and 1α-hydroxylase 25-hydroxy vitamin D in human thyroid cancer cell lines
    D Somjen
    Institute of Endocrinology, Metabolism and Hypertension, Tel Aviv Sourasky Medical Centre and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    J Steroid Biochem Mol Biol 136:80-2. 2013
    ....
  8. ncbi request reprint Age-dependent responsiveness of human female bone cells to vitamin D analog and PTH
    D Somjen
    Institute of Endocrinology, Metabolism and Hypertension, Tel Aviv Sourasky Medical Centre and The Sackler Faculty of Medicine Tel Aviv University, Tel Aviv 64239, Israel
    J Endocrinol Invest 36:118-22. 2013
    ..5. PTH and JKF stimulated DNA and CK in both Ob. In conclusion Ob demonstrate some age-dependent response to calciotrophic hormones, but the mechanism and beneficial outcome for human is unclear...
  9. doi request reprint Rivaroxaban, a direct inhibitor of the coagulation factor Xa interferes with hormonal-induced physiological modulations in human female osteoblastic cell line SaSO2
    Dalia Somjen
    Institute of Endocrinology, Metabolism and Hypertension, Tel Aviv Sourasky Medical Center and the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 64239, Israel
    J Steroid Biochem Mol Biol 135:67-70. 2013
    ..The relevance of these findings to human bone physiology is yet to be investigated...
  10. ncbi request reprint 25 hydroxy-vitamin D(3)-1alpha hydroxylase expression and activity in cultured human osteoblasts and their modulation by parathyroid hormone, estrogenic compounds and dihydrotestosterone
    Dalia Somjen
    Institute of Endocrinology, Metabolism and Hypertension, Tel Aviv University, Tel Aviv, Israel
    J Steroid Biochem Mol Biol 107:238-44. 2007
    ..The role of this local autocrine/paracrine 1,25D system in bone physiology deserves further investigation...
  11. ncbi request reprint Less-calcemic vitamin D analogs enhance creatine kinase specific activity and modulate responsiveness to gonadal steroids in rat skeletal tissues
    D Somjen
    Institute of Endocrinology, Metabolism and Hypertension, Tel Aviv Sourasky Medical Center, 6 Weizmann Street, Tel Aviv 64239, Israel
    J Endocrinol Invest 30:91-6. 2007
    ..These results corroborate our previous studies in human bone cells, and further suggest that the vitamin D system plays an important physiological role in maintaining normal cell energy reservoir in the skeleton...
  12. ncbi request reprint Systemic treatments with the low-calcemic 1,25(OH)(2)D(3) analogs JKF or QW increase both the morphological and biochemical responses to estradiol-17beta in rat tibiae
    D Somjen
    Institute of Endocrinology, Hypertension and Metabolism, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
    J Cell Biochem 100:1406-14. 2007
    ..We, therefore, conclude that combined treatment of less calcemic analogs vitamin D and E(2) might be superior for treatment of bone damage caused by ovariectomy in female rats and might be applied for post-menopausal osteoporosis...
  13. ncbi request reprint Responsiveness to estradiol-17beta and to phytoestrogens in primary human osteoblasts is modulated differentially by high glucose concentration
    Dalia Somjen
    Institute of Endocrinology, Metabolism and Hypertension, Tel Aviv Sourasky Medical Center and the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 64239, Israel
    J Steroid Biochem Mol Biol 99:139-46. 2006
    ....
  14. ncbi request reprint Vitamin D modulation of the activity of estrogenic compounds in bone cells in vitro and in vivo
    Dalia Somjen
    Institute of Endocrinology, Metabolism and Hypertension, Tel Aviv Sourasky Medical Center and the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    Crit Rev Eukaryot Gene Expr 17:115-47. 2007
    ....
  15. ncbi request reprint Daidzein but not other phytoestrogens preserves bone architecture in ovariectomized female rats in vivo
    D Somjen
    Institute of Endocrinology, Metabolism and Hypertension, Tel Aviv Sourasky Medical Center and the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 64239, Israel
    J Cell Biochem 103:1826-32. 2008
    ....
  16. doi request reprint Dihydrotestosterone and estradiol-17beta mutually neutralize their inhibitory effects on human vascular smooth muscle cell growth in vitro
    Dalia Somjen
    Institute of Endocrinlology, Metabolism and Hypertension, Tel Aviv Sourasky Medical Center and Sackler Faculty of Medicine, Tel Aviv University, 6 Weizman Street, Tel Aviv, Israel
    J Steroid Biochem Mol Biol 113:171-6. 2009
    ..These results suggest that while female and male sex hormones affect VSMC growth similarly, they interfere in a dose-, hormone- and MEK-dependent manner with each other's effect...
  17. doi request reprint The effects of native and synthetic estrogenic compounds as well as vitamin D less-calcemic analogs on adipocytes content in rat bone marrow
    D Somjen
    Institute of Endocrinology, Metabolism and Hypertension, Tel Aviv Sourasky Medical Centre, 6 Weizmann Street, Tel Aviv 64239, Israel
    J Endocrinol Invest 34:106-10. 2011
    ..We demonstrated previously that phytoestrogens and vitamin D analogs like estradiol-17β (E2) modulate bone morphology in rat female model...
  18. doi request reprint The effects of peptides with estrogen-like activity on cell proliferation and energy metabolism in human derived vascular smooth muscle cells
    D Somjen
    Sackler Faculty of Medicine, Institute of Endocrinology, Tel Aviv Medical Center, Tel Aviv University, Tel Aviv 64239, Israel
    J Cell Biochem 110:1142-6. 2010
    ..The results presented here suggest that EMP-1 provided it acts similarly in vivo can replace E(2) for treatment of post-menopausal women in hyperglycemia due to diabetes...
  19. doi request reprint DT56a (Femarelle), contrary to estradiol-17β, is effective in human derived female osteoblasts in hyperglycemic condition
    D Somjen
    Institute of Endocrinology, Metabolism and Hypertension, Tel Aviv Sourasky Medical Center, 6 Weizman St, Tel Aviv 64239, Israel
    J Steroid Biochem Mol Biol 123:25-9. 2011
    ..Since DT56a unlike E(2) is active in HG environment as well as in normal glucose, it may be an effective bone restoring agent in diabetic post-menopausal women...
  20. doi request reprint Sex specific response of cultured human bone cells to ERα and ERβ specific agonists by modulation of cell proliferation and creatine kinase specific activity
    Dalia Somjen
    Institute of Endocrinology, Metabolism and Hypertension, Tel Aviv Sourasky Medical Center and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 64239, Israel
    J Steroid Biochem Mol Biol 125:226-30. 2011
    ..In conclusion, we provide herein evidence for the separation of age- and sex-dependent mediation via both ERα and ERβ pathways in the effects of estrogens on hObs, with a yet unknown mechanism...
  21. ncbi request reprint The role of non-calcemic analogs of vitamin D in differentiation of cultured rat bone marrow into osteoblast-like cells: age and sex differences
    D Somjen
    Institute of Endocrinology, Hypertension and Metabolism, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
    J Endocrinol Invest 28:910-8. 2005
    ..Also non-calcemic vitamin D analogs were more effective in this process than 1,25D and showed activity even in the absence of DEX and may be applied to the differentiation process for bone tissue engineering...
  22. ncbi request reprint DT56a stimulates creatine kinase specific activity in vascular tissues of rats
    D Somjen
    Institute of Endocrinology, Metabolism and Hypertension, Tel Aviv Sourasky Medical Center, Israel
    J Endocrinol Invest 26:966-71. 2003
    ..These findings suggest that DT56a--which has similar beneficial effects on vascular tissues like that of E2--is probably mediated via common receptor(s)...
  23. doi request reprint The effects of estrogen receptors α- and β-specific agonists and antagonists on cell proliferation and energy metabolism in human bone cell line
    D Somjen
    Institute of Endocrinology, Metabolism and Hypertension, Tel Aviv Sourasky Medical Center and the Sackler Faculty of Medicine, Tel Aviv, Israel
    J Cell Biochem 112:625-32. 2011
    ..DPI did not affect hormonal-induced DNA and CK. In conclusion, we provide evidence for the separation of mediation via ERα and ERβ pathways in the effects of estrogenic compounds on osteoblasts, but the role of LO/HETE/ROS is unclear...
  24. ncbi request reprint Modulation of the response to estradiol-17beta of rat vascular tissues by a non calcemic vitamin D analog
    Dalia Somjen
    Tel Aviv Sourasky Medical Center, Institute of Endocrinology, Metabolism and Hypertension, 6 Weizman St, Tel Aviv 64239, Israel
    J Steroid Biochem Mol Biol 89:339-41. 2004
    ..These results should prompt examination of the possibility that the effects estrogen therapy in postmenopausal women can be augmented by vitamin D or its analogs...
  25. ncbi request reprint Modulation of response to estrogens in cultured human female bone cells by a non-calcemic Vitamin D analog: changes in nuclear and membranal binding
    Dalia Somjen
    Institute of Endocrinology, Metabolism and Hypertension, Tel Aviv Sourasky Medical Center, 6 Weizman St, Tel Aviv 64239, Israel
    J Steroid Biochem Mol Biol 89:393-5. 2004
    ..JKF pretreatment increased nuclear but decreased membranal binding in both age groups. These results provide evidence for membranal, in addition to nuclear estrogen receptors which are differentially modulated by a Vitamin D analog...
  26. ncbi request reprint A non-calcemic Vitamin D analog modulates both nuclear and putative membranal estrogen receptors in cultured human vascular smooth muscle cells
    Dalia Somjen
    Institute of Endocrinology, Metabolism and Hypertension, Tel Aviv Sourasky Medical Center, 6 Weizman Street, Tel Aviv 64239, Israel
    J Steroid Biochem Mol Biol 89:397-9. 2004
    ..The results provide evidence that the effects of JKF on ERalpha/ERbeta as well as on membranal versus nuclear binding of estrogen are divergent and show differential modulation...
  27. ncbi request reprint Estrogen-like activity of licorice root constituents: glabridin and glabrene, in vascular tissues in vitro and in vivo
    Dalia Somjen
    Institute of Endocrinology, Metabolism and Hypertension, Tel Aviv Sourasky Medical Center and the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 64239, Israel
    J Steroid Biochem Mol Biol 91:147-55. 2004
    ..Therefore, we suggest the use of glb with or without E2 as a new agent for modulation of vascular injury and atherogenesis for the prevention of cardiovascular diseases in post-menopausal women...
  28. ncbi request reprint Membranal effects of phytoestrogens and carboxy derivatives of phytoestrogens on human vascular and bone cells: new insights based on studies with carboxy-biochanin A
    D Somjen
    Institute of Endocrinology, Metabolism and Hypertension, Tel Aviv Sourasky Medical Centre and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 64239, Israel
    J Steroid Biochem Mol Biol 93:293-303. 2005
    ..The extent to which these properties of the novel synthetic phytoestrogen derivatives may be utilized to avert human vascular and/or bone disease requires further study...
  29. doi request reprint Mutual interaction of special phytoestrogenic compounds, their synthetic carboxy-derivatives and the less-calcemic vitamin D analog activities in human derived female cultured osteoblasts
    D Somjen
    Institute of Endocrinology, Metabolism and Hypertension and Bone Diseases Unit, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
    J Steroid Biochem Mol Biol 127:351-7. 2011
    ....
  30. ncbi request reprint Role of putative membrane receptors in the effects of estradiol on human vascular cell growth
    Dalia Somjen
    Institute of Endocrinology, Metabolism, and Hypertension, Tel Aviv Sourasky Medical Center, 6 Weizman Street, Tel Aviv 64239, Israel
    Am J Hypertens 17:462-9. 2004
    ..Hence, the effects of E(2) on DNA synthesis in human VSMC, but not in endothelial cells, are apparently exerted by membrane-binding sites for E(2) and do not require intracellular entry of E(2) through the classic nuclear receptor route...
  31. ncbi request reprint DT56a stimulates gender-specific human cultured bone cells in vitro
    Dalia Somjen
    Institute of Endocrinology, Metabolism and Hypertension, Tel Aviv Sourasky Medical Center and the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 64239, Israel
    J Steroid Biochem Mol Biol 98:90-6. 2006
    ..In summary, DT56a stimulated sex-specifically female-derived Ob, indicating its unique nature compared to the compounds currently used for postmenopausal osteoporosis by being bone-forming and not only an anti-resorptive agent...
  32. ncbi request reprint 25-hydroxyvitamin D3-1alpha-hydroxylase is expressed in human vascular smooth muscle cells and is upregulated by parathyroid hormone and estrogenic compounds
    Dalia Somjen
    Institute of Endocrinology, Metabolism and Hypertension, Tel Aviv Sourasky Medical Center, and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    Circulation 111:1666-71. 2005
    ..We therefore tested the possibility that VSMCs possess an endogenous 25-hydroxyvitamin D3-1alpha-hydroxylase system, the final enzyme in the biosynthetic pathway of 1,25(OH)2D3...
  33. ncbi request reprint Responsiveness to phytoestrogens in primary human osteoblasts is modulated differentially by a "less-calcemic" analog of 1,25 dihydroxyvitamin D(3): JK 1624F(2)-2 (JKF)
    Dalia Somjen
    Institute of Endocrinology, Metabolism and Hypertension, Tel Aviv Sourasky Medical Center, 6 Weizman St, Tel Aviv 64239, Israel
    J Steroid Biochem Mol Biol 98:139-46. 2006
    ..This study raises the possibility of combined Vitamin D analog and phytoestrogen for hormonal replacement therapy to prevent post-menopausal osteoporosis, which is a subject of ongoing research in animal models...
  34. ncbi request reprint DT56a (Tofupill/Femarelle) selectively stimulates creatine kinase specific activity in skeletal tissues of rats but not in the uterus
    Dalia Somjen
    Institute of Endocrinology, Metabolism and Hypertension, Tel Aviv Sourasky Medical Center, 64239, Tel Aviv, Israel
    J Steroid Biochem Mol Biol 86:93-8. 2003
    ..The effect of DT56a on other systems, such as the vascular and the central nervous system, are currently under investigation...
  35. doi request reprint Anti-proliferative effects of a novel isoflavone derivative in medullary thyroid carcinoma: an in vitro study
    Yona Greenman
    Institute of Endocrinology, Metabolism and Hypertension, Tel Aviv Sourasky Medical Center and the Sackler Faculty of Medicine, Tel Aviv University, Israel
    J Steroid Biochem Mol Biol 132:256-61. 2012
    ..The potent anti-proliferative effects mediated by isoflavone derivatives in the human MTC cell line TT suggest and that this property may be utilized to design effective anti-neoplastic agents...
  36. doi request reprint Lipoxygenase metabolites are mediators of PTH-dependent human osteoblast growth
    Dalia Somjen
    Institute of Endocrinology, Metabolism and Hypertension, Tel Aviv Sourasky Medical Center, Tel Aviv University, Tel Aviv 64239, Israel
    Bone 42:491-7. 2008
    ..Finally, PTH- induced ERK1/2 phosphorylation, was blocked by a MEK inhibitor. These results demonstrate a novel mechanism of PTH-induced human bone cell proliferation operating through LO enzymes...
  37. ncbi request reprint Less calcemic Vitamin D analogs enhance creatine kinase specific activity and modulate responsiveness to gonadal steroids in the vasculature
    Dalia Somjen
    Institute of Endocrinology, Metabolism and Hypertension, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
    J Steroid Biochem Mol Biol 101:232-8. 2006
    ..These results corroborate our previous in vitro studies in human vascular cells and further suggest that the Vitamin D system plays an important physiological role in maintaining normal cell energy reservoir in the vasculature...
  38. doi request reprint Estrogens and hyperglycemic modulation of mRNAs expressions involved in bone metabolism: an overshadowed association?
    Dalia Somjen
    Institute of Endocrinology, Metabolism and Hypertension, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
    Connect Tissue Res 54:176-80. 2013
    ..The exact mechanism of HG effects on bone cell responses is yet to be investigated and its relationship to human bone physiology is not yet clear...
  39. doi request reprint The effects of direct factor Xa inhibitor (Rivaroxaban) on the human osteoblastic cell line SaOS2
    Roy Gigi
    Division of Orthopedic Surgery, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
    Connect Tissue Res 53:446-50. 2012
    ..These findings might indicate that rivaroxaban inhibits the first stage of bone formation but does not affect later stages (i.e., bone mineralization)...
  40. pmc High glucose blocks the effects of estradiol on human vascular cell growth: differential interaction with estradiol and raloxifene
    Dalia Somjen
    Institute of Endocrinology, Metabolism and Hypertension, Tel Aviv Sourasky Medical Center, and Sackler Faculty of Medicine Tel Aviv University, 6 Weizman Street, Tel Aviv 64239, Rehovot, Israel
    J Steroid Biochem Mol Biol 88:101-10. 2004
    ....
  41. ncbi request reprint Treatment with non-hypercalcemic analogs of 1,25-dihydroxyvitamin D3 increases responsiveness to 17beta-estradiol, dihydrotestosterone or raloxifene in primary human osteoblasts
    Sara Katzburg
    Institute of Endocrinology, Sourasky Medical Center, 6 Weizman St Tel Aviv 64239, Israel
    J Steroid Biochem Mol Biol 88:213-9. 2004
    ..This study raises the possibility of testing combined Vitamin D analog and estrogen replacement treatment for post-menopausal women to prevent osteoporosis...
  42. doi request reprint Growth inhibition of human thyroid carcinoma and goiter cells in vitro by the isoflavone derivative 7-(O)-carboxymethyl daidzein conjugated to N-t-boc-hexylenediamine
    Dalia Somjen
    Institute of Endocrinology, Metabolism, and Hypertension, Tel Aviv University, Tel Aviv, Israel
    Thyroid 22:809-13. 2012
    ..Here we tested the hypothesis that cD-tboc can likewise retard cell growth in cultured human thyroid papillary carcinoma cells, normal thyroid cells, and goiter cells removed during thyroidectomy...
  43. ncbi request reprint DT56a (Femarelle) stimulates bone formation in female rats
    Dalia Somjen
    Institute of Endocrinology, Metabolism and Hypertension, Sourasky Medical Center and Sackler Faculty of Medicine, Tel Aviv University, Israel
    BJOG 112:981-5. 2005
    ..The aim of this study was to examine the effects of long term treatment (two months) with DT56a on the skeletal tissues of intact and ovariectomised (OVX) adult rats...
  44. doi request reprint A daidzein-daunomycin conjugate improves the therapeutic response in an animal model of ovarian carcinoma
    Dalia Somjen
    Institute of Endocrinology, Metabolism and Hypertension, Tel Aviv Sourasky Medical Center and the Sackler Faculty of Medicine, Tel Aviv University, Israel
    J Steroid Biochem Mol Biol 110:144-9. 2008
    ..These results indicate that targeting of daunomycin via carboxymethyldaidzein retains daunomycin's cytotoxic effects while averting its toxicity in an ovarian xenograft...
  45. ncbi request reprint Design, synthesis, and evaluation of peptides with estrogen-like activity
    Roni Kasher
    Department of Biological Chemistry, Weizmann Institute of Science, Rehovot 76100, Israel
    Biopolymers 76:404-20. 2004
    ..The short peptides described in this study may be used as potential lead compounds for developing new ER ligands...
  46. ncbi request reprint Synthesis and evaluation of the antiproliferative activities of derivatives of carboxyalkyl isoflavones linked to N-t-Boc-hexylenediamine
    Fortune Kohen
    Department of Biological Regulation and Chemical Research Support Unit, Weizmann Institute of Science, Rehovot, Israel
    J Med Chem 50:6405-10. 2007
    ..When tested in vivo, compound 6 decreased tumor volume of ovarian xenografts by 50%, with no apparent toxicity. Compound 6 may be a promising agent for therapy of cancer either alone or in combination with chemotherapeutic agents...