L S Freedman

Summary

Affiliation: Sieff Government Hospital
Country: Israel

Publications

  1. pmc Methods of epidemiology: evaluating the fat-breast cancer hypothesis--comparing dietary instruments and other developments
    Laurence S Freedman
    Gertner Institute for Epidemiology, Sheba Medical Center, Tel Hashomer, Israel
    Cancer J 14:69-74. 2008
  2. pmc Diabetes, glucose control, glucose lowering medications, and cancer risk: a 10-year population-based historical cohort
    Rachel Dankner
    Unit for Cardiovascular Epidemiology, The Gertner Institute for Epidemiology and Health Policy Research, Sheba Medical Center, Tel Hashomer, 52621, Israel
    BMC Cancer 12:364. 2012
  3. pmc A simple method for analyzing data from a randomized trial with a missing binary outcome
    Stuart G Baker
    Biometry Research Group, Division of Cancer Prevention, National Cancer Institute, USA
    BMC Med Res Methodol 3:8. 2003
  4. pmc Traumeel S for pain relief following hallux valgus surgery: a randomized controlled trial
    Shepherd R Singer
    The Center for Integrative Complementary Medicine, Shaare Zedek Medical Center, Jerusalem, Israel
    BMC Clin Pharmacol 10:9. 2010
  5. pmc A comparison of regression calibration, moment reconstruction and imputation for adjusting for covariate measurement error in regression
    Laurence S Freedman
    Gertner Institute for Epidemiology and Health Policy Research, Tel Hashomer, Israel
    Stat Med 27:5195-216. 2008
  6. pmc A population's mean Healthy Eating Index-2005 scores are best estimated by the score of the population ratio when one 24-hour recall is available
    Laurence S Freedman
    Gertner Institute for Epidemiology and Health Policy Research, Tel Hashomer, 52161 Israel
    J Nutr 138:1725-9. 2008
  7. doi request reprint An analysis of the controversy over classical one-sided tests
    Laurence S Freedman
    Gertner Institute for Epidemiology and Health Policy Research, Tel Hashomer 52161, Israel
    Clin Trials 5:635-40. 2008
  8. pmc The population distribution of ratios of usual intakes of dietary components that are consumed every day can be estimated from repeated 24-hour recalls
    Laurence S Freedman
    Gertner Institute for Epidemiology and Health Policy Research, Tel Hashomer 52161, Israel
    J Nutr 140:111-6. 2010
  9. pmc Can we use biomarkers in combination with self-reports to strengthen the analysis of nutritional epidemiologic studies?
    Laurence S Freedman
    Biostatistics Unit, Gertner Institute for Epidemiology, Tel Hashomer 52161, Israel
    Epidemiol Perspect Innov 7:2. 2010
  10. pmc A population's distribution of Healthy Eating Index-2005 component scores can be estimated when more than one 24-hour recall is available
    Laurence S Freedman
    Gertner Institute for Epidemiology and Health Policy Research, Tel Hashomer, Israel
    J Nutr 140:1529-34. 2010

Collaborators

Detail Information

Publications36

  1. pmc Methods of epidemiology: evaluating the fat-breast cancer hypothesis--comparing dietary instruments and other developments
    Laurence S Freedman
    Gertner Institute for Epidemiology, Sheba Medical Center, Tel Hashomer, Israel
    Cancer J 14:69-74. 2008
    ..The evidence is not yet conclusive, but additional follow-up in the randomized trial, as well as efforts to improve dietary assessment methodology for cohort studies, may be sufficient to provide a convincing answer...
  2. pmc Diabetes, glucose control, glucose lowering medications, and cancer risk: a 10-year population-based historical cohort
    Rachel Dankner
    Unit for Cardiovascular Epidemiology, The Gertner Institute for Epidemiology and Health Policy Research, Sheba Medical Center, Tel Hashomer, 52621, Israel
    BMC Cancer 12:364. 2012
    ....
  3. pmc A simple method for analyzing data from a randomized trial with a missing binary outcome
    Stuart G Baker
    Biometry Research Group, Division of Cancer Prevention, National Cancer Institute, USA
    BMC Med Res Methodol 3:8. 2003
    ..Although many previous adjustments for missing binary outcomes have been proposed, none of these makes explicit use of randomization to bound the bias when the data are not missing at random...
  4. pmc Traumeel S for pain relief following hallux valgus surgery: a randomized controlled trial
    Shepherd R Singer
    The Center for Integrative Complementary Medicine, Shaare Zedek Medical Center, Jerusalem, Israel
    BMC Clin Pharmacol 10:9. 2010
    ..We examined whether a well known and frequently prescribed homeopathic preparation could mitigate post-operative pain...
  5. pmc A comparison of regression calibration, moment reconstruction and imputation for adjusting for covariate measurement error in regression
    Laurence S Freedman
    Gertner Institute for Epidemiology and Health Policy Research, Tel Hashomer, Israel
    Stat Med 27:5195-216. 2008
    ..We demonstrate our findings with an analysis of dietary fat intake and mortality in a large cohort study...
  6. pmc A population's mean Healthy Eating Index-2005 scores are best estimated by the score of the population ratio when one 24-hour recall is available
    Laurence S Freedman
    Gertner Institute for Epidemiology and Health Policy Research, Tel Hashomer, 52161 Israel
    J Nutr 138:1725-9. 2008
    ..The results show that overall, the score of the population ratio is the preferred method. We therefore recommend that the quality of the U.S. population's diet be assessed and monitored using this method...
  7. doi request reprint An analysis of the controversy over classical one-sided tests
    Laurence S Freedman
    Gertner Institute for Epidemiology and Health Policy Research, Tel Hashomer 52161, Israel
    Clin Trials 5:635-40. 2008
    ..The choice between a one-sided and two-sided test still impacts on sample size calculations, assessment of study results by regulatory authorities, and publication of study results in academic journals...
  8. pmc The population distribution of ratios of usual intakes of dietary components that are consumed every day can be estimated from repeated 24-hour recalls
    Laurence S Freedman
    Gertner Institute for Epidemiology and Health Policy Research, Tel Hashomer 52161, Israel
    J Nutr 140:111-6. 2010
    ..The results changed only minimally when the other definition of usual intake, the usual ratio of intakes, was adopted...
  9. pmc Can we use biomarkers in combination with self-reports to strengthen the analysis of nutritional epidemiologic studies?
    Laurence S Freedman
    Biostatistics Unit, Gertner Institute for Epidemiology, Tel Hashomer 52161, Israel
    Epidemiol Perspect Innov 7:2. 2010
    ....
  10. pmc A population's distribution of Healthy Eating Index-2005 component scores can be estimated when more than one 24-hour recall is available
    Laurence S Freedman
    Gertner Institute for Epidemiology and Health Policy Research, Tel Hashomer, Israel
    J Nutr 140:1529-34. 2010
    ..41, respectively. An estimated 30% of the total population had a score of <2.5 for total vegetables. This is the first time, to our knowledge, that estimated distributions of usual HEI-2005 component scores have been published...
  11. pmc Gains in statistical power from using a dietary biomarker in combination with self-reported intake to strengthen the analysis of a diet-disease association: an example from CAREDS
    Laurence S Freedman
    Biostatistics Unit, Gertner Institute for Epidemiology, Tel Hashomer, Israel
    Am J Epidemiol 172:836-42. 2010
    ..The authors conclude that combining appropriate biomarkers with dietary data in a cohort can strengthen the investigation of diet-disease associations by increasing the statistical power to detect them...
  12. pmc Using regression calibration equations that combine self-reported intake and biomarker measures to obtain unbiased estimates and more powerful tests of dietary associations
    Laurence S Freedman
    Biostatistics Unit, Gertner Institute for Epidemiology and Health Policy Research, Tel Hashomer, Israel
    Am J Epidemiol 174:1238-45. 2011
    ..This development sheds light on previous analyses of diet-disease associations reported in the literature...
  13. ncbi request reprint Quantitative science methods for biomarker validation in chemoprevention trials
    Laurence Freedman
    Bar Ilan University and Gertner Institute for Epidemiology and Health Policy Research, Tel Hashomer, Israel
    Cancer Biomark 3:135-40. 2007
    ..Researchers may have to resign themselves to more limited use of surrogate outcomes, not as replacements for traditional outcomes, but as outcomes for Phase II studies designed to decide which interventions to pass for Phase III testing...
  14. ncbi request reprint A comparison of population-based cancer incidence rates in Israel and Jordan
    L S Freedman
    Middle East Cancer Consortium, Bar Ilan University, Ramat Gan, Israel
    Eur J Cancer Prev 12:359-65. 2003
    ..Hodgkin lymphoma rates in Israeli non-Jews and Jordanians are similar to SEER, but non-Hodgkin lymphoma rates are lower than SEER. The previous suspicion of higher overall leukaemia and lymphoma rates in Jordan is thus not confirmed...
  15. ncbi request reprint Cancer registration in the Middle East
    L S Freedman
    Department of Mathematics Statistics and Computer Science, Bar Ilan University, Ramat Gan, Israel
    Epidemiology 12:131-3. 2001
    ....
  16. doi request reprint Prediction of nonSVR to therapy with pegylated interferon-alpha2a and ribavirin in chronic hepatitis C genotype 1 patients after 4, 8 and 12 weeks of treatment
    E Lukasiewicz
    The Mina and Everard Goodman Faculty of Life Sciences, Bar Ilan University, Ramat Gan, Israel
    J Viral Hepat 17:345-51. 2010
    ..796). These results indicate that lack of sustained viral response is best predicted after 8 weeks of treatment and that waiting until 12 weeks does not improve the prediction...
  17. ncbi request reprint Dietary intake changes and their association with ovarian cancer risk
    Flora Lubin
    Biostatistics Unit, Gertner Institute, Sheba Medical Center, Tel Hashomer, Israel
    J Nutr 136:2362-7. 2006
    ..65/100 kcal (418.4 kJ), 95% CI = 0.50 - 0.85]. Our results suggest that substitution of nonanimal for animal fat during adult life might reduce the risk of ovarian cancer, but this requires confirmation in prospective studies...
  18. doi request reprint Using biomarker data to adjust estimates of the distribution of usual intakes for misreporting: application to energy intake in the US population
    Rivka Yanetz
    Department of Mathematics, Bar Ilan University, Ramat Gan, Israel
    J Am Diet Assoc 108:455-64; discussion 464. 2008
    ....
  19. doi request reprint Functional variant of KLOTHO: a breast cancer risk modifier among BRCA1 mutation carriers of Ashkenazi origin
    I Wolf
    The Institute of Oncology, Chaim Sheba Medical Center, Ramat Gan, Israel
    Oncogene 29:26-33. 2010
    ..These data suggest KL-VS as a breast and ovarian cancer risk modifier among BRCA1 mutation carriers. If validated in additional cohorts, the presence of KL-VS may serve as a predictor of cancer risk among BRCA1 mutation carriers...
  20. ncbi request reprint A new method for dealing with measurement error in explanatory variables of regression models
    Laurence S Freedman
    Department of Mathematics and Statistics, Bar Ilan University, Ramat Gan 52900, Israel
    Biometrics 60:172-81. 2004
    ..Finally, we give an example of the use of moment reconstruction in linear discriminant analysis and a nonstandard problem where we wish to adjust a classification tree for measurement error in the explanatory variables...
  21. ncbi request reprint Adjustments to improve the estimation of usual dietary intake distributions in the population
    Laurence S Freedman
    Department of Mathematics, Statistics and Computer Science, Bar Ilan University, Ramat Gan, Israel
    J Nutr 134:1836-43. 2004
    ..Incorporating UN assessments into nutritional surveys, therefore, deserves serious consideration...
  22. doi request reprint A modified approach to estimating sample size for simple logistic regression with one continuous covariate
    I Novikov
    Biostatistics Unit, Gertner Institute for Epidemiology and Health Policy Research, Israel
    Stat Med 29:97-107. 2010
    ..This approach appears to increase the accuracy of the sample size estimates for LR with one continuous covariate...
  23. ncbi request reprint A comparison of two dietary instruments for evaluating the fat-breast cancer relationship
    Laurence S Freedman
    Gertner Institute for Epidemiology, Tel Hashomer, Israel
    Int J Epidemiol 35:1011-21. 2006
    ..We assessed this further using 4 day food records (FRs) and FFQs in a large sample...
  24. ncbi request reprint A statistical comparison of different family history scores
    H Murad
    Biostatistics Unit, Gertner Institute, Sheba Medical Center, Tel Hashomer, Israel
    Stat Med 26:2785-98. 2007
    ..Since the proportion score (the proportion of first-degree relatives of the index who have the disease) is the simplest to calculate, use of this score seems to be justified...
  25. ncbi request reprint Body mass index at age 18 years and during adult life and ovarian cancer risk
    F Lubin
    Cancer Epidemiology Unit, Gertner Institute, Sheba Medical Center, Tel Hashomer, Israel
    Am J Epidemiol 157:113-20. 2003
    ..The authors conclude that, in their population, body mass index at age 18 years is an independent risk factor for ovarian cancer...
  26. ncbi request reprint Estimating and testing interactions in linear regression models when explanatory variables are subject to classical measurement error
    Havi Murad
    Department of Mathematics and Statistics, Bar Ilan University, Ramat Gan, Israel
    Stat Med 26:4293-310. 2007
    ..However, when the true covariates are not normally distributed, we recommend using MM. We provide an example relating homocysteine to serum folate and B12 levels...
  27. ncbi request reprint Abandon neither the food frequency questionnaire nor the dietary fat-breast cancer hypothesis
    Laurence S Freedman
    Cancer Epidemiol Biomarkers Prev 16:1321-2. 2007
  28. ncbi request reprint Statistical methods for estimating usual intake of nutrients and foods: a review of the theory
    Kevin W Dodd
    National Cancer Institute, Bethesda, MD 20892
    J Am Diet Assoc 106:1640-50. 2006
    ..These differences can result in estimated usual intake distributions that differ from one another. We also demonstrate the need for an improved method for estimating usual intake distributions for episodically consumed foods...
  29. doi request reprint The role of dietary measurement error in investigating the hypothesized link between dietary fat intake and breast cancer--a story with twists and turns
    Anne C M Thiebaut
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892 7232, USA
    Cancer Invest 26:68-73. 2008
    ..They describe the twists and turns of the dietary fat and breast cancer debate that have revolved around this issue...
  30. pmc A new statistical method for estimating the usual intake of episodically consumed foods with application to their distribution
    Janet A Tooze
    J Am Diet Assoc 106:1575-87. 2006
    ..We propose a new statistical method that uses information from two 24-hour recalls to estimate usual intake of episodically consumed foods...
  31. ncbi request reprint Performance of a food-frequency questionnaire in the US NIH-AARP (National Institutes of Health-American Association of Retired Persons) Diet and Health Study
    Frances E Thompson
    US National Cancer Institute, EPN 4016, 9000 Rockville Pike, Bethesda, MD 20893 7344, USA
    Public Health Nutr 11:183-95. 2008
    ....
  32. ncbi request reprint A comparison of a food frequency questionnaire with a 24-hour recall for use in an epidemiological cohort study: results from the biomarker-based Observing Protein and Energy Nutrition (OPEN) study
    Arthur Schatzkin
    Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA
    Int J Epidemiol 32:1054-62. 2003
    ..We use data from the Observing Protein and Energy Nutrition (OPEN) study to compare the performance of a FFQ with that of a 24-hour recall (24HR)...
  33. ncbi request reprint Linear measurement error models with restricted sampling
    Malka Gorfine
    Faculty of Industrial Engineering and Management, Technion Israel Institute of Technology, Technion City, Haifa 3200, Israel
    Biometrics 63:137-42. 2007
    ..Results of a simulation study along with a sensitivity analysis are presented, showing the performance of the proposed method under a simple linear regression model...
  34. ncbi request reprint Structure of dietary measurement error: results of the OPEN biomarker study
    Victor Kipnis
    Biometry Research Group, Division of Cancer Prevention, National Cancer Institute, Bethesda, MD 20892 7354, USA
    Am J Epidemiol 158:14-21; discussion 22-6. 2003
    ..Results suggest that the interpretation of findings from FFQ-based epidemiologic studies of diet-disease associations needs to be reevaluated...
  35. ncbi request reprint The food propensity questionnaire: concept, development, and validation for use as a covariate in a model to estimate usual food intake
    Amy F Subar
    National Cancer Institute, Bethesda, MD 20892, USA
    J Am Diet Assoc 106:1556-63. 2006
    ....
  36. pmc Binary regression in truncated samples, with application to comparing dietary instruments in a large prospective study
    Douglas Midthune
    Biometry Research Group, Division of Cancer Prevention, National Cancer Institute, Executive Plaza North, Room 3131, 6130 Executive Boulevard, MSC 7354, Bethesda, MD 20892 7354, USA
    Biometrics 64:289-98. 2008
    ....