Uri Seligsohn

Summary

Country: Israel

Publications

  1. doi request reprint Treatment of inherited platelet disorders
    U Seligsohn
    Amalia Biron Institute of Thrombosis and Hemostasis, Sheba Medical Center, Tel Hashomer and Sackler Faculity of Medicine, Tel Aviv University, Israel
    Haemophilia 18:161-5. 2012
  2. ncbi request reprint [Inherited bleeding disorders common in Jews]
    Uri Seligsohn
    Amalia Biron Research Institute of Thrombosis and Hemostasis Sheba Medical Center, and Sackler Faculty of Medicine, Tel Aviv University
    Harefuah 149:298-303, 335. 2010
  3. ncbi request reprint Glanzmann thrombasthenia: a model disease which paved the way to powerful therapeutic agents
    Uri Seligsohn
    Institute of Thrombosis and Hemostasis, The Chaim Sheba Medical Center, Tel Hashomer, Israel
    Pathophysiol Haemost Thromb 32:216-7. 2002
  4. doi request reprint Factor XI deficiency in humans
    U Seligsohn
    Amalia Biron Research Institute of Thrombosis and Hemostasis, Sheba Medical Center, Tel Hashomer, Israel
    J Thromb Haemost 7:84-7. 2009
  5. ncbi request reprint Factor XI in haemostasis and thrombosis: past, present and future
    Uri Seligsohn
    The Amalia Biron Research Institute of Thrombosis and Hemostasis, Chaim Sheba Medical Center, Tel Hashomer 52621, Israel
    Thromb Haemost 98:84-9. 2007
  6. ncbi request reprint Deciphering the mystery of combined factor V and factor VIII deficiency
    U Seligsohn
    Amalia Biron Research Institute of Thrombosis and Hemostasis, Sheba Medical Center, 52621 Tel Hashomer, Israel
    J Thromb Haemost 4:927-31. 2006
  7. ncbi request reprint Disulfide bond disruption by a beta 3-Cys549Arg mutation in six Jordanian families with Glanzmann thrombasthenia causes diminished production of constitutively active alpha IIb beta 3
    Ronit Mor-Cohen
    Amalia Biron Research Institute of Thrombosis and Hemostasis, Chaim Sheba Medical Center, Tel Hashomer, Israel 52621
    Thromb Haemost 98:1257-65. 2007
  8. doi request reprint Recombinant activated factor VII and tranexamic acid are haemostatically effective during major surgery in factor XI-deficient patients with inhibitor antibodies
    Tami Livnat
    The Amalia Biron Research Institute of Thrombosis and Hemostasis, Sheba Medical Center, Tel Hashomer and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    Thromb Haemost 102:487-92. 2009
  9. doi request reprint Patients with severe factor XI deficiency have a reduced incidence of deep-vein thrombosis
    Ophira Salomon
    The Amalia Biron Research Institute of Thrombosis and Hemostasis, Sheba Medical Center, Tel Hashomer 52621, Israel
    Thromb Haemost 105:269-73. 2011
  10. doi request reprint A unique interaction between alphaIIb and beta3 in the head region is essential for outside-in signaling-related functions of alphaIIbbeta3 integrin
    Hagit Hauschner
    Amalia Biron Research Institute of Thrombosis and Hemostasis, Chaim Sheba Medical Center, Tel Hashomer, Israel
    Blood 115:4542-50. 2010

Collaborators

Detail Information

Publications44

  1. doi request reprint Treatment of inherited platelet disorders
    U Seligsohn
    Amalia Biron Institute of Thrombosis and Hemostasis, Sheba Medical Center, Tel Hashomer and Sackler Faculity of Medicine, Tel Aviv University, Israel
    Haemophilia 18:161-5. 2012
    ..Menorrhagia later in life can be managed by continuous oral contraceptives. Depo-medroxyprogesterone acetate administered every 3 months is an alternative when combined oral contraceptives are contraindicated...
  2. ncbi request reprint [Inherited bleeding disorders common in Jews]
    Uri Seligsohn
    Amalia Biron Research Institute of Thrombosis and Hemostasis Sheba Medical Center, and Sackler Faculty of Medicine, Tel Aviv University
    Harefuah 149:298-303, 335. 2010
    ..On the basis of data obtained from the research of Glanzmann thrombasthenia, several widely used drugs have been developed as effective antithrombotic agents...
  3. ncbi request reprint Glanzmann thrombasthenia: a model disease which paved the way to powerful therapeutic agents
    Uri Seligsohn
    Institute of Thrombosis and Hemostasis, The Chaim Sheba Medical Center, Tel Hashomer, Israel
    Pathophysiol Haemost Thromb 32:216-7. 2002
    ..Currently, the main benefit afforded by these agents has been observed in patients undergoing percutaneous coronary interventions who are at high risk of thrombosis but more indications for their use are evolving...
  4. doi request reprint Factor XI deficiency in humans
    U Seligsohn
    Amalia Biron Research Institute of Thrombosis and Hemostasis, Sheba Medical Center, Tel Hashomer, Israel
    J Thromb Haemost 7:84-7. 2009
    ..In patients with an inhibitor to FXI, recombinant factor VIIa is useful...
  5. ncbi request reprint Factor XI in haemostasis and thrombosis: past, present and future
    Uri Seligsohn
    The Amalia Biron Research Institute of Thrombosis and Hemostasis, Chaim Sheba Medical Center, Tel Hashomer 52621, Israel
    Thromb Haemost 98:84-9. 2007
  6. ncbi request reprint Deciphering the mystery of combined factor V and factor VIII deficiency
    U Seligsohn
    Amalia Biron Research Institute of Thrombosis and Hemostasis, Sheba Medical Center, 52621 Tel Hashomer, Israel
    J Thromb Haemost 4:927-31. 2006
  7. ncbi request reprint Disulfide bond disruption by a beta 3-Cys549Arg mutation in six Jordanian families with Glanzmann thrombasthenia causes diminished production of constitutively active alpha IIb beta 3
    Ronit Mor-Cohen
    Amalia Biron Research Institute of Thrombosis and Hemostasis, Chaim Sheba Medical Center, Tel Hashomer, Israel 52621
    Thromb Haemost 98:1257-65. 2007
    ..In conclusion, the novel ancestral mutation found in a cluster of Jordanian GT patients disrupts a conserved Cys549-Cys558 bond which results in reduced production of constitutively active alpha IIb beta 3...
  8. doi request reprint Recombinant activated factor VII and tranexamic acid are haemostatically effective during major surgery in factor XI-deficient patients with inhibitor antibodies
    Tami Livnat
    The Amalia Biron Research Institute of Thrombosis and Hemostasis, Sheba Medical Center, Tel Hashomer and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    Thromb Haemost 102:487-92. 2009
    ..No excessive bleeding or thrombosis were observed. In conclusion, a single low dose of rFVIIa and tranexamic acid secure normal haemostasis in patients with severe FXI deficiency who can not receive blood products...
  9. doi request reprint Patients with severe factor XI deficiency have a reduced incidence of deep-vein thrombosis
    Ophira Salomon
    The Amalia Biron Research Institute of Thrombosis and Hemostasis, Sheba Medical Center, Tel Hashomer 52621, Israel
    Thromb Haemost 105:269-73. 2011
    ..68) computed from the population-based study. The low incidence remains statistically significant when compared to three other population-based studies. These data suggest that severe FXI deficiency provides protection against DVT...
  10. doi request reprint A unique interaction between alphaIIb and beta3 in the head region is essential for outside-in signaling-related functions of alphaIIbbeta3 integrin
    Hagit Hauschner
    Amalia Biron Research Institute of Thrombosis and Hemostasis, Chaim Sheba Medical Center, Tel Hashomer, Israel
    Blood 115:4542-50. 2010
    ..Together, these findings indicate that the interaction between Trp110 of alphaIIb and Arg261 of beta3 is critical for alphaIIbbeta3 integrity and outside-in signaling-related functions...
  11. ncbi request reprint Age estimates of ancestral mutations causing factor VII deficiency and Dubin-Johnson syndrome in Iranian and Moroccan Jews are consistent with ancient Jewish migrations
    Ronit Mor-Cohen
    The Amalia Biron Research Institute of Thrombosis and Hemostasis, Chaim Sheba Medical Center, Tel Hashomer and Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
    Blood Coagul Fibrinolysis 18:139-44. 2007
    ....
  12. pmc Unique disulfide bonds in epidermal growth factor (EGF) domains of β3 affect structure and function of αIIbβ3 and αvβ3 integrins in different manner
    Ronit Mor-Cohen
    The Amalia Biron Research Institute of Thrombosis and Hemostasis, Chaim Sheba Medical Center, Tel Hashomer, Israel
    J Biol Chem 287:8879-91. 2012
    ....
  13. ncbi request reprint A mutation in LMAN1 (ERGIC-53) causing combined factor V and factor VIII deficiency is prevalent in Jews originating from the island of Djerba in Tunisia
    Avichai Segal
    Thrombosis and Hemostasis Research Institute, Chaim Sheba Medical Center, Tel Hashomer and Sackler Faculty of Medicine, Tel Aviv University, Israel
    Blood Coagul Fibrinolysis 15:99-102. 2004
    ..0123), but in none of 180 Iranian Jews examined. In view of the relatively low frequency of the mutations in the respective populations it seems reasonable to advocate carrier detection and prenatal diagnosis only in affected families...
  14. doi request reprint Specific cysteines in beta3 are involved in disulfide bond exchange-dependent and -independent activation of alphaIIbbeta3
    Ronit Mor-Cohen
    Amalia Biron Research Institute of Thrombosis and Hemostasis, Chaim Sheba Medical Center, Tel Hashomer 52621
    J Biol Chem 283:19235-44. 2008
    ..These data suggest that different disulfide bonds in beta3 EGF and beta-tail domains play variable structural and regulatory roles in alphaIIbbeta3...
  15. ncbi request reprint Inhibitors to Factor XI in patients with severe Factor XI deficiency
    Ophira Salomon
    Amalia Biron Research Institute of Thrombosis and Hemostasis, Chaim Sheba Medical Center, Tel Hashomer, Israel
    Semin Hematol 43:S10-2. 2006
    ..Further work is required to determine the optimal dosing schedules of the agent in this indication...
  16. ncbi request reprint Characterization of seven novel mutations causing factor XI deficiency
    Michal Zucker
    The Amalia Biron Research Institute of Thrombosis and Hemostasis, Chaim Sheba Medical Center, Tel Hashomer and Sackler Faculty of Medicine, Tel Aviv University, Israel
    Haematologica 92:1375-80. 2007
    ..The objective of this study was to identify the mutations in 15 unrelated FXI-deficient patients and characterize missense mutations by expression in baby hamster kidney (BHK) cells...
  17. doi request reprint Reduced incidence of ischemic stroke in patients with severe factor XI deficiency
    Ophira Salomon
    The Amalia Biron Research Institute of Thrombosis and Hemostasis, Sheba Medical Center, Tel Hashomer and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    Blood 111:4113-7. 2008
    ..Thus, severe factor XI deficiency probably is protective against ischemic stroke but not against acute myocardial infarction...
  18. ncbi request reprint Effect of four missense mutations in the factor XIII A-subunit gene on protein stability: studies with recombinant proteins
    Alex Vysokovsky
    Institute of Thrombosis and Hemostasis, Sheba Medical Center, Tel Hashomer, Israel
    Blood Coagul Fibrinolysis 17:125-30. 2006
    ..The Arg260Leu, Ala318Val, Thr398Asn and Gly210Arg mutations in FXIII A-subunit cause rapid intracellular degradation of the corresponding mutated protein...
  19. doi request reprint Cataract extraction without prophylactic treatment in patients with severe factor XI deficiency
    Ido Didi Fabian
    The Goldschleger Eye Institute, Tel Aviv University, Tel Aviv, Israel
    Am J Ophthalmol 148:920-4.e1. 2009
    ..To assess the risks of intraoperative and postoperative bleeding associated with cataract extraction without prophylactic treatment in patients with severe factor XI (FXI) deficiency...
  20. ncbi request reprint Major mutations in calf-1 and calf-2 domains of glycoprotein IIb in patients with Glanzmann thrombasthenia enable GPIIb/IIIa complex formation, but impair its transport from the endoplasmic reticulum to the Golgi apparatus
    Nurit Rosenberg
    Thrombosis and Hemostasis Research Institute, The Chaim Sheba Medical Center, Tel Hashomer, Israel
    Blood 101:4808-15. 2003
    ..These data suggest that despite partial disruption of calf-1 or calf-2 domain, GPIIb/IIIa complex is formed but its transport from the endoplasmic reticulum is impaired...
  21. doi request reprint Risk factors for failure of heparin thromboprophylaxis in patients with acute traumatic spinal cord injury
    Deborah Rubin-Asher
    Department of Neurological Rehabilitation, The Chaim Sheba Medical Center, Tel Hashomer, and Sackler Faculty of Medicine, Tel Aviv University, Israel
    Thromb Res 125:501-4. 2010
    ..48%, p=0.006). Multiple logistic regression proved the PT mutation, a positive family history of thrombosis and elevated levels of either FVIII or Hcy to be predictors of thrombosis...
  22. ncbi request reprint Nonarteritic anterior ischemic optic neuropathy is associated with a specific platelet polymorphism located on the glycoprotein Ibalpha gene
    Ophira Salomon
    Institute of Thrombosis and Hemostasis, Sheba Medical Center, Tel Hashomer, Israel Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    Ophthalmology 111:184-8. 2004
    ..To evaluate the association between platelet glycoprotein polymorphisms and the risks of single and second eye involvement with nonarteritic anterior ischemic optic neuropathy (NAION)...
  23. ncbi request reprint Prevalence, causes, and characterization of factor XI inhibitors in patients with inherited factor XI deficiency
    Ophira Salomon
    Thrombosis and Hemostasis Research Institute, Tissue Typing Laboratory, Sheba Medical Center, Tel Hashomer, Israel
    Blood 101:4783-8. 2003
    ..The results imply that patients with a very low factor XI level are susceptible to development of an inhibitor following plasma replacement...
  24. ncbi request reprint Plasma replacement therapy during labor is not mandatory for women with severe factor XI deficiency
    Ophira Salomon
    Amalia Biron Research Institute of Thrombosis and Hemostasis, Chaim Sheba Medical Center, Tel Hashomer, Israel
    Blood Coagul Fibrinolysis 16:37-41. 2005
    ..For women requiring cesarean section it appears that the same policy can be advocated but more observations are needed...
  25. doi request reprint Plasma levels of microparticles at 24 weeks of gestation do not predict subsequent pregnancy complications
    Ophira Salomon
    Amalia Biron Research Institute of Thrombosis and Hemostasis, Sheba Medical Center, Tel Hashomer and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    Fertil Steril 92:682-7. 2009
    ..To discern whether plasma levels of microparticles (MPs) measured at 24 weeks of gestation predict late complications of pregnancy...
  26. ncbi request reprint Of four mutations in the factor VII gene in Tunisian patients, one novel mutation (Ser339Phe) in three unrelated families abrogates factor X activation
    Yonit Fromovich-Amit
    Amalia Biron Research Institute of Thrombosis and Hemostasis, Chaim Sheba Medical Center, Tel Hashomer, Israel
    Blood Coagul Fibrinolysis 16:369-74. 2005
    ..The major defect of FVII Ser339Phe was its inability to activate factor X in the presence of tissue factor. Modeling predicted that the substitution of Ser339 by Phe abrogated substrate docking...
  27. doi request reprint Disulfide bond exchanges in integrins αIIbβ3 and αvβ3 are required for activation and post-ligation signaling during clot retraction
    Ronit Mor-Cohen
    The Amalia Biron Research Institute of Thrombosis and Hemostasis, Chaim Sheba Medical Center, Tel Hashomer, Israel Sackler Faculty of Medicine, Tel Aviv University, Israel Electronic address
    Thromb Res 133:826-36. 2014
    ..Integrin αIIbβ3 mediates platelet adhesion, aggregation and fibrin clot retraction. These processes require activation of αIIbβ3 and post-ligation signaling. Disulfide bond exchanges are involved in αIIbβ3 and αvβ3 activation...
  28. ncbi request reprint Prothrombin 20210G>A is an ancestral prothrombotic mutation that occurred in whites approximately 24,000 years ago
    Ariella Zivelin
    The Amalia Biron Research Institute of Thrombosis and Hemostasis, Chaim Sheba Medical Center, Tel Hashomer 52621, Israel
    Blood 107:4666-8. 2006
    ....
  29. doi request reprint Variable effects of alpha v suppression on VEGFR-2 expression in endothelial cells of different vascular beds
    Rima Dardik
    The Amalia Biron Research Institute of Thrombosis and Hemostasis, Chaim Sheba Medical Center, Israel
    Thromb Haemost 102:975-82. 2009
    ..Hence, therapeutic antiangiogenic intervention by siRNA- mediated suppression of alphav integrins should take into account variable and potentially hazardous responses in different vascular beds...
  30. ncbi request reprint Induction of an inhibitor antibody to factor XI in a patient with severe inherited factor XI deficiency by Rh immune globulin
    Michal Zucker
    Amalia Biron Research Institute of Thrombosis and Hemostasis, Chaim Sheba Medical Center, Tel Hashomer and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    Blood 111:1306-8. 2008
    ..Clinicians should be aware of the potential for immunization of severely FXI-deficient patients by FXI present in Rh immune globulin preparations...
  31. ncbi request reprint Molecular diversity of Glanzmann thrombasthenia in southern India: new insights into mRNA splicing and structure-function correlations of alphaIIbbeta3 integrin (ITGA2B, ITGB3)
    Hava Peretz
    Clinical Biochemistry Laboratory, Sourasky Medical Center, Tel Aviv, Israel
    Hum Mutat 27:359-69. 2006
    ....
  32. ncbi request reprint Factor XI deficiency in French Basques is caused predominantly by an ancestral Cys38Arg mutation in the factor XI gene
    Ariella Zivelin
    Institute of Thrombosis and Hemostasis, Chaim Sheba Medical Center, Tel Hashomer 52621, Israel
    Blood 99:2448-54. 2002
    ..005. Haplotype analysis based on the study of 10 intragenic polymorphisms was consistent with a common ancestry (a founder effect) for the Cys38Arg mutation...
  33. ncbi request reprint High prevalences of vitamin B12 and folic acid deficiency in elderly subjects in Israel
    Elizabeth Figlin
    Department of Hematology, Institute of Thrombosis and Hemostasis, Chaim Sheba Medical Centre, Tel Hashomer, Israel
    Br J Haematol 123:696-701. 2003
    ..69, 95% CI 2.27-6.01). These data suggest that malnutrition is a major cause of the highly prevalent deficiencies of vitamin B12 and/or folic acid in elderly Israeli subjects dwelling at home...
  34. ncbi request reprint The common prothrombotic factors in nulliparous women do not compromise blood flow in the feto-maternal circulation and are not associated with preeclampsia or intrauterine growth restriction
    Ophira Salomon
    The Amalia Biron Thrombosis and Hemostasis Research Institute, Chaim Sheba Medical Center, Tel Hashomer, Israel
    Am J Obstet Gynecol 191:2002-9. 2004
    ..In this study we evaluated the associations between common prothrombotic factors and increased blood flow resistance in the feto-maternal circulation, intrauterine growth restriction, small for gestational age, or preeclampsia...
  35. ncbi request reprint ADAMTS-13 regulates platelet adhesion under flow. A new method for differentiation between inherited and acquired thrombotic thrombocytopenic purpura
    Boris Shenkman
    Institute of Thrombosis and Hemostasis, Sheba Medical Center, Tel Hashomer 52621, Israel
    Thromb Haemost 96:160-6. 2006
    ....
  36. pmc The frequent 5,10-methylenetetrahydrofolate reductase C677T polymorphism is associated with a common haplotype in whites, Japanese, and Africans
    Nurit Rosenberg
    Institute of Thrombosis and Hemostasis, Chaim Sheba Medical Center, Tel Hashomer, Israel
    Am J Hum Genet 70:758-62. 2002
    ..These results suggest that the MTHFR 677T alteration occurred on a founder haplotype that may have had a selective advantage...
  37. ncbi request reprint Bleeding due to disruption of a cargo-specific ER-to-Golgi transport complex
    Bin Zhang
    Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109 0650, USA
    Nat Genet 34:220-5. 2003
    ..MCFD2 is localized to the ERGIC through a direct, calcium-dependent interaction with LMAN1. These findings suggest that the MCFD2-LMAN1 complex forms a specific cargo receptor for the ER-to-Golgi transport of selected proteins...
  38. doi request reprint Simultaneous genotyping of coagulation factor XI type II and type III mutations by multiplex real-time polymerase chain reaction to determine their prevalence in healthy and factor XI-deficient Italians
    Giorgia Zadra
    Department of Biology and Genetics for Medical Sciences, via Viotti 3 5, 20133 Milan, Italy
    Haematologica 93:715-21. 2008
    ....
  39. pmc Genotype-phenotype correlation in combined deficiency of factor V and factor VIII
    Bin Zhang
    Genomic Medicine Institute, Lerner Research Institute, Cleveland Clinic Foundation, OH 44195, USA
    Blood 111:5592-600. 2008
    ..These data suggest that MCFD2 may play a primary role in the export of FV and FVIII from the ER, with the impact of LMAN1 mediated indirectly through its interaction with MCFD2...
  40. ncbi request reprint The neurology of cobalamin deficiency in an elderly population in Israel
    Natan Gadoth
    Dept of Neurology, Meir General Hospital, Kfar Saba 44281, Israel
    J Neurol 253:45-50. 2006
    ..To evaluate the neurological status in elderly subjects with cobalamin deficiency (CblD) compared with matched non-deficient subjects before and after cobalamin (Cbl) supplementation...
  41. pmc Discerning the ancestry of European Americans in genetic association studies
    Alkes L Price
    Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS Genet 4:e236. 2008
    ..We demonstrate that this panel of markers can be used to correct for stratification in association studies that do not generate dense genotype data...
  42. ncbi request reprint Prenatal diagnosis of Glanzmann thrombasthenia
    Alok Srivastava
    Department of Haematology, Christian Medical College, Vellore 632004, Tamil Nadu, India
    Natl Med J India 16:207-8. 2003
    ..Platelet transfusions are often needed to control the bleeding. Glanzmann thrombasthenia results from mutations in the genes located on chromosome 17q21-23, encoding the platelet glycoprotein (GP) IIb/IIIa receptor...
  43. ncbi request reprint Upregulation of osteoclast alpha2beta1 integrin compensates for lack of alphavbeta3 vitronectin receptor in Iraqi-Jewish-type Glanzmann thrombasthenia
    Michael A Horton
    Departments of Medicine and Histopathology, University College London, London, UK
    Br J Haematol 122:950-7. 2003
    ..This explains why Iraqi-Jewish patients with GT do not have osteopetrosis...
  44. ncbi request reprint [Clinical and economical advantages of anticoagulant treatment in specialized clinics]
    Yifaat Goldberg
    Department of Internal Medicine D, Tel Aviv Sourasky Medical Center
    Harefuah 141:830-2, 856. 2002
    ..In this review we evaluate the efficacy of warfarin treatment in anticoagulant clinics in comparison with regular community clinics and analyze the economic aspects of preventing warfarin complications...