Mitchell J Schwaber

Summary

Country: Israel

Publications

  1. ncbi Epidemiological interpretation of antibiotic resistance studies - what are we missing?
    Mitchell J Schwaber
    Division of Epidemiology, Tel Aviv Sourasky Medical Center, Tel Aviv 64239, Israel
    Nat Rev Microbiol 2:979-83. 2004
  2. pmc Antimicrobial resistance and patient outcomes: the hazards of adjustment
    Mitchell J Schwaber
    Division of Epidemiology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
    Crit Care 10:164. 2006
  3. pmc Predictors of carbapenem-resistant Klebsiella pneumoniae acquisition among hospitalized adults and effect of acquisition on mortality
    Mitchell J Schwaber
    Division of Epidemiology and Preventive Medicine, Tel Aviv Sourasky Medical Center, 6 Weizmann St, Tel Aviv 64239, Israel
    Antimicrob Agents Chemother 52:1028-33. 2008
  4. ncbi Mortality and delay in effective therapy associated with extended-spectrum beta-lactamase production in Enterobacteriaceae bacteraemia: a systematic review and meta-analysis
    Mitchell J Schwaber
    Division of Epidemiology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
    J Antimicrob Chemother 60:913-20. 2007
  5. doi Containment of a country-wide outbreak of carbapenem-resistant Klebsiella pneumoniae in Israeli hospitals via a nationally implemented intervention
    Mitchell J Schwaber
    National Center for Infection Control, Israel Ministry of Health, Tel Aviv, Israel
    Clin Infect Dis 52:848-55. 2011
  6. pmc The effect of antimicrobial resistance on patient outcomes: importance of proper evaluation of appropriate therapy
    Mitchell J Schwaber
    National Center for Infection Control, Israel Ministry of Health, Tel Aviv, Israel
    Crit Care 13:106. 2009
  7. pmc Clinical and economic impact of bacteremia with extended- spectrum-beta-lactamase-producing Enterobacteriaceae
    Mitchell J Schwaber
    Division of Epidemiology, Tel Aviv Sourasky Medical Center, 6 Weizmann St, Tel Aviv 64239, Israel
    Antimicrob Agents Chemother 50:1257-62. 2006
  8. pmc Utility of the VITEK 2 Advanced Expert System for identification of extended-spectrum beta-lactamase production in Enterobacter spp
    Mitchell J Schwaber
    Division of Epidemiology, Tel Aviv Sourasky Medical Center, Israel
    J Clin Microbiol 44:241-3. 2006
  9. doi High prevalence of methicillin-resistant Staphylococcus aureus among residents and staff of long-term care facilities, involving joint and parallel evolution
    Mitchell J Schwaber
    National Center for Infection Control, Israel Ministry of Health, Tel Aviv, Israel
    Clin Infect Dis 53:910-3. 2011
  10. pmc Transfer of carbapenem-resistant plasmid from Klebsiella pneumoniae ST258 to Escherichia coli in patient
    Moran G Goren
    Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
    Emerg Infect Dis 16:1014-7. 2010

Detail Information

Publications45

  1. ncbi Epidemiological interpretation of antibiotic resistance studies - what are we missing?
    Mitchell J Schwaber
    Division of Epidemiology, Tel Aviv Sourasky Medical Center, Tel Aviv 64239, Israel
    Nat Rev Microbiol 2:979-83. 2004
    ..A more appropriate measure of this burden is the rate of isolation of resistant organisms, that is, the absolute number of resistant isolates in a population over time...
  2. pmc Antimicrobial resistance and patient outcomes: the hazards of adjustment
    Mitchell J Schwaber
    Division of Epidemiology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
    Crit Care 10:164. 2006
    ..We discuss how failure to distinguish between confounders and intermediate variables can bias the analysis, and we address methods of approaching this issue...
  3. pmc Predictors of carbapenem-resistant Klebsiella pneumoniae acquisition among hospitalized adults and effect of acquisition on mortality
    Mitchell J Schwaber
    Division of Epidemiology and Preventive Medicine, Tel Aviv Sourasky Medical Center, 6 Weizmann St, Tel Aviv 64239, Israel
    Antimicrob Agents Chemother 52:1028-33. 2008
    ..6; and P = 0.03; for the CRKP group versus the controls, OR, 5.0; 95% CI, 1.7 to 14.8; and P = 0.004). CRKP affects patients with poor functional status, an ICU stay, and antibiotic exposure and is an independent predictor of death...
  4. ncbi Mortality and delay in effective therapy associated with extended-spectrum beta-lactamase production in Enterobacteriaceae bacteraemia: a systematic review and meta-analysis
    Mitchell J Schwaber
    Division of Epidemiology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
    J Antimicrob Chemother 60:913-20. 2007
    ..We performed a systematic review and meta-analysis to examine the impact of extended-spectrum beta-lactamase (ESBL) production on mortality and delay in effective therapy in Enterobacteriaceae bacteraemia...
  5. doi Containment of a country-wide outbreak of carbapenem-resistant Klebsiella pneumoniae in Israeli hospitals via a nationally implemented intervention
    Mitchell J Schwaber
    National Center for Infection Control, Israel Ministry of Health, Tel Aviv, Israel
    Clin Infect Dis 52:848-55. 2011
    ..A nationwide intervention was launched to contain the outbreak and to introduce a strategy to control future dissemination of antibiotic-resistant bacteria in hospitals...
  6. pmc The effect of antimicrobial resistance on patient outcomes: importance of proper evaluation of appropriate therapy
    Mitchell J Schwaber
    National Center for Infection Control, Israel Ministry of Health, Tel Aviv, Israel
    Crit Care 13:106. 2009
    ..In the absence of these data, the effect of delay or absence of appropriate therapy in patients infected with resistant bacterial pathogens is subject to confounding, and the true effect of resistance on outcomes may be obscured...
  7. pmc Clinical and economic impact of bacteremia with extended- spectrum-beta-lactamase-producing Enterobacteriaceae
    Mitchell J Schwaber
    Division of Epidemiology, Tel Aviv Sourasky Medical Center, 6 Weizmann St, Tel Aviv 64239, Israel
    Antimicrob Agents Chemother 50:1257-62. 2006
    ..ESBL production was associated with severe adverse outcomes, including higher overall and infection-related mortality, increased LOS, DAT, discharge to chronic care, and higher costs...
  8. pmc Utility of the VITEK 2 Advanced Expert System for identification of extended-spectrum beta-lactamase production in Enterobacter spp
    Mitchell J Schwaber
    Division of Epidemiology, Tel Aviv Sourasky Medical Center, Israel
    J Clin Microbiol 44:241-3. 2006
    ..5%), and erroneously reported cephalosporin susceptibility in 11 isolates (28%). Refinements in the AES are required in order to improve ESBL detection in Enterobacter...
  9. doi High prevalence of methicillin-resistant Staphylococcus aureus among residents and staff of long-term care facilities, involving joint and parallel evolution
    Mitchell J Schwaber
    National Center for Infection Control, Israel Ministry of Health, Tel Aviv, Israel
    Clin Infect Dis 53:910-3. 2011
    ..All strains were Panton-Valentine leukocidin-negative. The epidemiology of MRSA among residents and staff involved joint and parallel evolution...
  10. pmc Transfer of carbapenem-resistant plasmid from Klebsiella pneumoniae ST258 to Escherichia coli in patient
    Moran G Goren
    Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
    Emerg Infect Dis 16:1014-7. 2010
    ..The KPC-3 plasmid was identical in isolates of both species. The patient's gut flora contained a carbapenem-susceptible E. coli strain isogenic with the KPC-3-producing isolate, which suggests horizontal interspecies plasmid transfer...
  11. pmc Isolation of imipenem-resistant Enterobacter species: emergence of KPC-2 carbapenemase, molecular characterization, epidemiology, and outcomes
    Dror Marchaim
    Division of Epidemiology, Tel Aviv Sourasky Medical Center, 6 Weizmann St, Tel Aviv 64239, Israel
    Antimicrob Agents Chemother 52:1413-8. 2008
    ..IRE infections are associated with increased mortality. Enhanced measures to control the hospital spread of IRE are warranted...
  12. pmc Emergence of KPC-2 and KPC-3 in carbapenem-resistant Klebsiella pneumoniae strains in an Israeli hospital
    Azita Leavitt
    Division of Epidemiology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
    Antimicrob Agents Chemother 51:3026-9. 2007
    ..This rapid dissemination of KPC outside the United States is worrisome...
  13. pmc Evaluation of PCR-based testing for surveillance of KPC-producing carbapenem-resistant members of the Enterobacteriaceae family
    Vered Schechner
    Division of Epidemiology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
    J Clin Microbiol 47:3261-5. 2009
    ..blaKPC PCR-based testing is a useful method for the surveillance of KPC-producing CRE. Its main advantage over culturing is a shorter time to result, and it may prove to be more sensitive...
  14. pmc First report on a hyperepidemic clone of KPC-3-producing Klebsiella pneumoniae in Israel genetically related to a strain causing outbreaks in the United States
    Shiri Navon-Venezia
    Division of Epidemiology, Tel Aviv Sourasky Medical Center, Israel
    Antimicrob Agents Chemother 53:818-20. 2009
    ..The threat of the global spread of hyperepidemic, extensively drug-resistant bacterial strains should be recognized and confronted...
  15. ncbi Carbapenem-resistant Klebsiella pneumoniae in post-acute-care facilities in Israel
    Debby Ben-David
    National Center for Infection Control, Israel Ministry of Health, Tel Aviv, Israel
    Infect Control Hosp Epidemiol 32:845-53. 2011
    ..To assess the prevalence of and risk factors for carbapenem-resistant Klebsiella pneumoniae (CRKP) carriage among patients in post-acute-care facilities (PACFs) in Israel...
  16. doi Plasmid pKpQIL encoding KPC-3 and TEM-1 confers carbapenem resistance in an extremely drug-resistant epidemic Klebsiella pneumoniae strain
    Azita Leavitt
    Molecular Epidemiology and Antimicrobial Resistance Laboratory, Division of Epidemiology, Tel Aviv Medical Center, Tel Aviv, Israel
    J Antimicrob Chemother 65:243-8. 2010
    ..We aimed to characterize the local KPC-3-encoding plasmid carried by these isolates and study its contribution to antibiotic resistance...
  17. pmc Epidemiological and microbiological characteristics of an outbreak caused by OXA-48-producing Enterobacteriaceae in a neonatal intensive care unit in Jerusalem, Israel
    Amos Adler
    National Center for Infection Control, Ministry of Health, Tel Aviv, Israel
    J Clin Microbiol 51:2926-30. 2013
    ..This plasmid, similar to the global blaOXA-48-harboring vector, has now acquired blaCTX-M-14, leading to resistance to all β-lactam agents. ..
  18. ncbi Molecular and epidemiologic study of polyclonal outbreaks of multidrug-resistant Acinetobacter baumannii infection in an Israeli hospital
    Dror Marchaim
    Division of Epidemiology, Tel Aviv Sourasky Medical Center, Sackler School of Medicine, Tel Aviv University, Tel Aviv, 64239, Israel
    Infect Control Hosp Epidemiol 28:945-50. 2007
    ....
  19. doi Pseudomonas aeruginosa bacteremia upon hospital admission: risk factors for mortality and influence of inadequate empirical antimicrobial therapy
    Vered Schechner
    Division of Epidemiology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
    Diagn Microbiol Infect Dis 71:38-45. 2011
    ..029) were identified as independent predictors of mortality. Inadequate empirical antimicrobial therapy was marginally associated with increased mortality only among patients who presented with severe sepsis or septic shock (P = 0.051)...
  20. ncbi Introduction of OXA-48-producing Enterobacteriaceae to Israeli hospitals by medical tourism
    Amos Adler
    National Center for Infection Control, Israel Ministry of Health, Tel Aviv, Israel
    J Antimicrob Chemother 66:2763-6. 2011
    ..It is mostly encoded on a single plasmid in various Enterobacteriaceae species. We characterized the epidemiological and molecular features of OXA-48-producing Enterobacteriaceae (OPE) in Israel...
  21. pmc Plasmid-mediated imipenem-hydrolyzing enzyme KPC-2 among multiple carbapenem-resistant Escherichia coli clones in Israel
    Shiri Navon-Venezia
    Division of Epidemiology, Tel Aviv Sourasky Medical Center, Tel Aviv University, Israel
    Antimicrob Agents Chemother 50:3098-101. 2006
    ..This is the first discovery of KPC-2 in E. coli and the first report of this enzyme originating outside the United States...
  22. ncbi Clonal transmission of a rare methicillin-resistant Staphylococcus aureus genotype between horses and staff at a veterinary teaching hospital
    Mitchell J Schwaber
    National Center for Infection Control, Israel Ministry of Health, 6 Weizmann St, Tel Aviv 64239, Israel
    Vet Microbiol 162:907-11. 2013
    ....
  23. pmc A swordless knight: epidemiology and molecular characteristics of the blaKPC-negative sequence type 258 Klebsiella pneumoniae clone
    Amos Adler
    National Center for Infection Control, Ministry of Health, Tel Aviv, Israel
    J Clin Microbiol 50:3180-5. 2012
    ..pneumoniae isolates collected in the two centers. Our results suggest that ERCNKP ST-258 evolved by loss of the bla(KPC)-carrying plasmid pKpQIL. ERCNKP ST-258 appears to have low epidemic potential...
  24. pmc Evaluation of an accelerated protocol for detection of extended-spectrum beta-lactamase-producing gram-negative bacilli from positive blood cultures
    Shiri Navon-Venezia
    Molecular Epidemiology Laboratory, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, 6 Weizman St, Tel Aviv 64239, Israel
    J Clin Microbiol 43:439-41. 2005
    ..Results of the direct ESBL testing were reported 2.3 days sooner and were comparable to those of the standard NCCLS method with sensitivity, specificity, and positive and negative predictive values of 100, 98, 94, and 100%, respectively...
  25. pmc High levels of antimicrobial coresistance among extended-spectrum-beta-lactamase-producing Enterobacteriaceae
    Mitchell J Schwaber
    Division of Epidemiology, Tel Aviv Sourasky Medical Center, 6 Weizmann St, Tel Aviv 64239, Israel
    Antimicrob Agents Chemother 49:2137-9. 2005
    ..ESBL nonproducers were more often susceptible to these agents. ESBL-producing Enterobacteriaceae represent a major source of resistance to various antibiotics...
  26. pmc CTX-M-2 and a new CTX-M-39 enzyme are the major extended-spectrum beta-lactamases in multiple Escherichia coli clones isolated in Tel Aviv, Israel
    Inna Chmelnitsky
    Division of Epidemiology and Laboratory for Molecular Epidemiology and Antibiotic Research, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Israel
    Antimicrob Agents Chemother 49:4745-50. 2005
    ..We report here a new CTX-M gene, designated bla(CTX-M-39), which revealed 99% homology with bla(CTX-M-26), with a substitution of arginine for glutamine at position 225...
  27. pmc Ertapenem resistance among extended-spectrum-beta-lactamase-producing Klebsiella pneumoniae isolates
    Azita Leavitt
    Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    J Clin Microbiol 47:969-74. 2009
    ..These rare resistant subpopulations carried multiple ESBL genes, including TEM-30, SHV-44, CTX-M-2, and CTX-M-10, and they lacked OMPK36. The clinical and diagnostic significance of the results should be further studied...
  28. pmc Molecular epidemiology, sequence types, and plasmid analyses of KPC-producing Klebsiella pneumoniae strains in Israel
    Azita Leavitt
    Molecular Epidemiology and Antimicrobial Resistance Laboratory, Division of Epidemiology, Tel Aviv Medical Center, Tel Aviv, Israel
    Antimicrob Agents Chemother 54:3002-6. 2010
    ..coli followed by limited clonal spread, whereas KPC-3 carriage in this species is related almost strictly to clonal expansion of ST 258 carrying pKpQIL...
  29. pmc Prevalence of Streptococcus pneumoniae in respiratory samples from patients with tracheostomy in a long-term-care facility
    Amos Adler
    National Center for Infection Control, Ministry of Health, Tel Aviv, Israel
    J Clin Microbiol 50:3368-70. 2012
    ..However, the proportion of positive endotracheal cultures was higher than that of nasopharyngeal cultures in adults (18% versus 3%, respectively; P < 0.001) but not in children (17% in both sites)...
  30. doi How to stem the tide of carbapenemase-producing enterobacteriaceae?: proactive versus reactive strategies
    Efraim Bilavsky
    Division of Epidemiology and Preventive Medicine, Tel Aviv Sourasky Medical Center, Israel
    Curr Opin Infect Dis 23:327-31. 2010
    ..The purpose of this review is to highlight the impact of these problematic pathogens and to examine infection control policies needed in order to limit their spread...
  31. pmc Extended-spectrum beta-lactamases among Enterobacter isolates obtained in Tel Aviv, Israel
    Jacob Schlesinger
    Division of Epidemiology, Tel Aviv Sourasky Medical Center, 6 Weizmann St, Tel Aviv 64239, Israel
    Antimicrob Agents Chemother 49:1150-6. 2005
    ..The dominant ESBL identified was SHV-12...
  32. pmc Epidemiological interpretation of studies examining the effect of antibiotic usage on resistance
    Vered Schechner
    Division of Epidemiology and Preventive Medicine, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
    Clin Microbiol Rev 26:289-307. 2013
    ..Approaches to measuring antibiotic use and antibiotic resistance are presented. Important methodological issues such as confounding, establishing temporality, and control group selection are examined...
  33. doi The effects of group 1 versus group 2 carbapenems on imipenem-resistant Pseudomonas aeruginosa: an ecological study
    Yehuda Carmeli
    Division of Epidemiology, Tel Aviv Sourasky Medical Center, Tel Aviv 64239, Israel
    Diagn Microbiol Infect Dis 70:367-72. 2011
    ..0625) in multivariate analysis. Ertapenem was not associated with IMP-R PA. These data would support preferentially prescribing ertapenem rather than group 2 carbapenems where clinically appropriate...
  34. ncbi Emergence of VIM-producing Aeromonas caviae in Israeli hospitals
    Amos Adler
    National Center for Infection Control, Ministry of Health, Tel Aviv, Israel
    J Antimicrob Chemother 69:1211-4. 2014
    ..Our aims were to describe the molecular characteristics of the first cases of VIM-producing Aeromonas caviae isolated from human samples...
  35. ncbi A national intervention to prevent the spread of carbapenem-resistant enterobacteriaceae in israeli post-acute care hospitals
    Debby Ben-David
    National Center for Infection Control, Israel Ministry of Health, Tel Aviv, Israel
    Infect Control Hosp Epidemiol 35:802-9. 2014
    ..Conclusion. A nationwide infection control intervention was associated with enhanced infection control measures and a reduction in the prevalence of CRE in PACHs. ..
  36. pmc Surveillance cultures and duration of carriage of multidrug-resistant Acinetobacter baumannii
    Dror Marchaim
    Division of Epidemiology, Tel Aviv Sourasky Medical Center, 6 Weizmann St, Tel Aviv 64239, Israel
    J Clin Microbiol 45:1551-5. 2007
    ..The proportion of individuals with previous MDR A. baumannii isolation who remain carriers for prolonged periods is substantial. These data should be considered when designing measures to limit the spread of MDR A. baumannii...
  37. doi Gram-negative bacteremia upon hospital admission: when should Pseudomonas aeruginosa be suspected?
    Vered Schechner
    Division of Epidemiology, Sourasky Medical Center, Tel Aviv, Israel
    Clin Infect Dis 48:580-6. 2009
    ..aeruginosa. We sought to determine the occurrence of and construct a model to predict P. aeruginosa bacteremia upon hospital admission...
  38. pmc National multicenter study of predictors and outcomes of bacteremia upon hospital admission caused by Enterobacteriaceae producing extended-spectrum beta-lactamases
    Dror Marchaim
    Division of Epidemiology, Tel Aviv Sourasky Medical Center, 6 Weizmann St, Tel Aviv 64239, Israel
    Antimicrob Agents Chemother 54:5099-104. 2010
    ..Efforts should be directed to improving the detection of patients with ESBL bacteremia UHA and to providing immediate appropriate therapy...
  39. doi Dissemination of the CTX-M-25 family beta-lactamases among Klebsiella pneumoniae, Escherichia coli and Enterobacter cloacae and identification of the novel enzyme CTX-M-41 in Proteus mirabilis in Israel
    Shiri Navon-Venezia
    Division of Epidemiology, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    J Antimicrob Chemother 62:289-95. 2008
    ..We aimed to describe the occurrence and to understand the dissemination of this extended-spectrum beta-lactamase family among Enterobacteriaceae strains in our hospital...
  40. ncbi High tigecycline resistance in multidrug-resistant Acinetobacter baumannii
    Shiri Navon-Venezia
    The Laboratory for Molecular Epidemiology and Antibiotic Research, Department of Epidemiology, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    J Antimicrob Chemother 59:772-4. 2007
    ..We aimed to evaluate the in vitro activity of tigecycline against MDR A. baumannii clones isolated before tigecycline was used in our institution...
  41. ncbi [Infliximab in inflammatory bowel diseases--conference summary and suggested guidelines]
    Iris Dotan
    Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
    Harefuah 145:844-9, 860. 2006
    ..These guidelines may assist and direct the gastroenterologist treating inflammatory bowel disease patients with infliximab...
  42. doi Parental Staphylococcus aureus carriage is associated with staphylococcal carriage in young children
    Gili Regev-Yochay
    Infectious Diseases Unit, Sheba Medical Center and Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
    Pediatr Infect Dis J 28:960-5. 2009
    ..Our previous study suggested that S. aureus carriage in children is associated with parental carriage. Here we wished to distinguish the different components that play a role in the risk to a child of a S. aureus-carrying parent...
  43. doi An ongoing national intervention to contain the spread of carbapenem-resistant enterobacteriaceae
    Mitchell J Schwaber
    National Center for Infection Control, Tel Aviv, Israel
    Clin Infect Dis 58:697-703. 2014
    ..During the intervention, nosocomial CRE acquisition in acute care declined from a monthly high of 55.5 to an annual low of 4.8 cases per 100,000 patient-days (P < .001)...
  44. ncbi A prospective study of plasma C-peptide and colorectal cancer risk in men
    Jing Ma
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Natl Cancer Inst 96:546-53. 2004
    ..We used the concentration of plasma C-peptide (an indicator of insulin production) to determine whether insulin and insulin resistance are associated with the risk of developing colorectal cancer...
  45. pmc Methicillin-resistant Staphylococcus aureus in neonatal intensive care unit
    Gili Regev-Yochay
    Infectious Diseases Unit, Sheba Medical Center, Tel Hashomer, Ramat Gan, 52621 Israel
    Emerg Infect Dis 11:453-6. 2005
    ..Fifteen infected neonates were identified, 2 of whom died. This outbreak illustrates how a rare community pathogen can rapidly spread through nosocomial transmission...