Research Topics
| Itamar RazSummaryCountry: Israel Publications
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Detail Information
Publications
Rational therapy for diabetes: early recognition of adverse effects and avoidance of disruptive false alarmsItamar Raz
Diabetes Unit, Hadassah University Hospital, Jerusalem, Israel
Diabetes Metab Res Rev 28:321-4. 2012..Adherence to strict scientific methodology, ongoing large clinical trials and creating adjudicated patient databases may facilitate early recognition of adverse effects while avoiding disruptive false alarms...
Efficacy and safety of taspoglutide monotherapy in drug-naive type 2 diabetic patients after 24 weeks of treatment: results of a randomized, double-blind, placebo-controlled phase 3 study (T-emerge 1)Itamar Raz
Diabetes Unit, Department of Internal Medicine, Hadassah Ein Kerem Hospital, Jerusalem, Israel
Diabetes Care 35:485-7. 2012..To evaluate the efficacy and safety of taspoglutide monotherapy in drug-naive patients with type 2 diabetes inadequately controlled...- The continuing need for drug development and clinical trials in type 2 diabetes and its complications: introduction to the RDS special issueItamar Raz
Diabetes Unit, Department of Medicine, Hadassah Hebrew University Hospital, Jerusalem 91120, Israel
Rev Diabet Stud 8:288-92. 2011..We conclude that further drug development and clinical trials are required to overcome these limitations, and to counteract the movement towards higher incidence rates of T2D and its complications... 
Efficacy and safety of biphasic insulin aspart 30 combined with pioglitazone in type 2 diabetes poorly controlled on glibenclamide (glyburide) monotherapy or combination therapy: an 18-week, randomized, open-label studyItamar Raz
Diabetes Unit, Hadassah Hebrew University Hospital, Jerusalem, Israel
Clin Ther 27:1432-43. 2005..Few large randomized controlled trials have assessed the value of adding insulin to an oral antidiabetic drug regimen...- Addition of biphasic insulin aspart 30 to rosiglitazone in type 2 diabetes mellitus that is poorly controlled with glibenclamide monotherapyItamar Raz
Hadassah Ein Karem Medical Center, Jerusalem, Israel
Clin Ther 25:3109-23. 2003..The incidence of type 2 diabetes mellitus (DM) is rapidly increasing worldwide. Results from large-scale studies show that tight blood glucose (BG) control improves the outcome of patients with type 2 DM... - Diabetes: insulin resistance and derangements in lipid metabolism. Cure through intervention in fat transport and storageItamar Raz
Department of Medicine, Diabetes Center, Hadassah University Hospital, Jerusalem 91120, Israel
Diabetes Metab Res Rev 21:3-14. 2005..Among surgical procedures, gastric bypass has been proven to produce beneficial results in advance of other surgical techniques, the evidence basis of which still needs strengthening... - Effect of a local heating device on insulin and glucose pharmacokinetic profiles in an open-label, randomized, two-period, one-way crossover study in patients with type 1 diabetes using continuous subcutaneous insulin infusionItamar Raz
The Diabetes Center, Hadassah Hebrew University School of Medicine, Jerusalem, Israel
Clin Ther 31:980-7. 2009..InsuPatch (InsuLine Medical Ltd., Petach-Tikva, Israel) is a device intended to accelerate subcutaneous insulin delivery using an insulin pump by locally warming the infusion site... - Differences in mtDNA haplogroup distribution among 3 Jewish populations alter susceptibility to T2DM complicationsJeanette Feder
Department of Life Sciences and National Institute of Biotechnology in the Negev, Ben Gurion University of the Negev, Beer Sheva, Israel
BMC Genomics 9:198. 2008..Nevertheless these large-scale population screens often overlook the tremendous variation in the mitochondrial genome (mtDNA) and its involvement in complex disorders... - Dose-response relationship of oral insulin spray in healthy subjectsSimona Cernea
Diabetes Unit, Dept of Medicine, Hadassah Hospital, POB 12000, Jerusalem, Israel 91120
Diabetes Care 28:1353-7. 2005..A dose-response relationship in the absorption and metabolic effect of the oral insulin was noted... - Dose-response relationship of an oral insulin spray in six patients with type 1 diabetes: a single-center, randomized, single-blind, 5-way crossover studySimona Cernea
Diabetes Unit, Internal Medicine Department, Hadassah Hebrew University Hospital, Jerusalem, Israel
Clin Ther 27:1562-70. 2005..A dose-response relationship was noted in the metabolic effect and absorption of oral insulin spray... - Role of protein kinase C in the expression of endothelin converting enzyme-1Mogher Khamaisi
Department of Medicine, Diabetes Research Unit, Hadassah Hospital, Ein Kerem, Mt Scopus, and the Hebrew University Medical School, Jerusalem, Israel
Endocrinology 150:1440-9. 2009..These results show that enhanced ECE-1 expression induced by hyperglycemia is partly due to activation of the PKC-delta isoform. Thus, inhibition of this PKC isoform may prevent diabetes-related increase in ET-1... - Role of insulin and the IGF system in renal hypertrophy in diabetic Psammomys obesus (sand rat)Itamar Raz
Diabetes Center and Department of Internal Medicine, Hadassah University Hospital, Jerusalem, Israel
Nephrol Dial Transplant 18:1293-8. 2003..The implication of this finding is that the pathophysiological mechanisms for diabetic kidney disease in experimental models may be different for type 1 and type 2 DM... - Role of renal nitric oxide synthase in diabetic kidney disease during the chronic phase of diabetesMogher Khamaisi
Department of Internal Medicine B, Diabetes Center, Hadassah University Hospital, Jerusalem, Israel
Nephron Physiol 102:p72-80. 2006..To evaluate the role of NO in developing diabetic kidney disease, we studied the NO system in streptozotocin (STZ)-induced diabetic rats for a period of 8 weeks... - Efficacy and safety of sitagliptin added to ongoing metformin therapy in patients with type 2 diabetesItamar Raz
Diabetes Unit, Department of Internal Medicine, Hadassah Hebrew University Hospital, Jerusalem, Israel
Curr Med Res Opin 24:537-50. 2008..The purpose of this study was to evaluate the efficacy and safety of sitagliptin as an add-on to metformin therapy in patients with moderately severe (hemoglobin A(1c) >or= 8.0% and <or= 11.0%) type 2 diabetes mellitus (T2DM)... - Post hoc subgroup analysis of the HEART2D trial demonstrates lower cardiovascular risk in older patients targeting postprandial versus fasting/premeal glycemiaItamar Raz
Department of Internal Medicine, Hadassah Hospital, Jerusalem, Israel
Diabetes Care 34:1511-3. 2011..To identify the Hyperglycemia and Its Effect After Acute Myocardial Infarction on Cardiovascular Outcomes in Patients With Type 2 Diabetes Mellitus (HEART2D) trial subgroups with treatment difference... - Assessment of insulin resistance by a 13C glucose breath test: a new tool for early diagnosis and follow-up of high-risk patientsMeir Mizrahi
Department of Medicine, Liver Unit, Hebrew University Hadassah Medical Center Ein Karem, Jerusalem 12000, Israel
Nutr J 9:25. 2010..The BreathID system can continuously analyse breath samples in real-time at the point-of-care. Here we determined the efficacy of the BreathID using the 13C-Glucose breath test (GBT) for evaluation of insulin resistance... - Effects of prandial versus fasting glycemia on cardiovascular outcomes in type 2 diabetes: the HEART2D trialItamar Raz
Internal Medicine, Hadassah Hospital, Jerusalem, Israel
Diabetes Care 32:381-6. 2009.... - Cardiovascular disease in type 2 diabetics: epidemiology, risk factors and therapeutic modalitiesMogher Khamaisi
Diabetes Center, Department of Internal Medicine, Hadassah University Hospital, Jerusalem, Israel
Isr Med Assoc J 5:801-6. 2003.... - Immune modulation in type 1 diabetes mellitus using DiaPep277: a short review and update of recent clinical trial resultsRoy Eldor
Diabetes Research Center, Department of Medicine, Hadassah Hebrew University Hospital, Jerusalem 91120, Israel
Diabetes Metab Res Rev 25:316-20. 2009.... - In-hospital treatment of hyperglycemia: effects of intensified subcutaneous insulin treatmentHila Elinav
Endocrinology and Metabolism Service and the Hadassah Diabetes Center, Department of Medicine, Hadassah Hebrew University Medical Center, Jerusalem, Israel
Curr Med Res Opin 23:757-65. 2007..No methods for achievement of proper glycemic control in this population have been validated in the in-hospital setting... - Effects of moderate intensity glycemic control after cardiac surgeryGil Leibowitz
Department of Medicine, Endocrinology and Metabolism Service and Hadassah Diabetes Center, Jerusalem, Israel
Ann Thorac Surg 90:1825-32. 2010..We used a protocol based on dynamic insulin administration targeted to achieve moderately tight glycemic control and tested its impact on clinical outcomes after cardiac surgery... - Effect of mild hypoinsulinemia on renal hypertrophy: growth hormone/insulin-like growth factor I system in mild streptozotocin diabetesMogher Khamaisi
Diabetes Center and Department of Internal Medicine, Hadassah University Hospital, Jerusalem, Israel
Int J Exp Diabetes Res 3:257-64. 2002.... - The Controversies in Obesity, Diabetes and Hypertension (CODHy) meeting: what is it all about?Itamar Raz
Diabetes Center, Hadassah Hebrew School of Medicine, Jerusalem, Israel
Diabetes Care 31:S111-2. 2008 - Comparison of pharmacokinetic and pharmacodynamic properties of single-dose oral insulin spray and subcutaneous insulin injection in healthy subjects using the euglycemic clamp techniqueSimona Cernea
Diabetes Unit, Department of Internal Medicine, Hadassah-Hebrew University Hospital, PO Box 12000, Jerusalem 91120, Israel
Clin Ther 26:2084-91. 2004..The short T(max) and the 120-minute duration of effect of oral insulin spray suggest it may be a promising alternative for fulfilling meal-related insulin requirements in persons with diabetes... - Different contributions of insulin resistance and beta-cell dysfunction in overweight Israeli Arabs with IFG and IGTMuhammad A Abdul-Ghani
Department of Diabetes, Lin Medical Center, Clalit Health Services, Haifa and Diabetes Unit, Hadassah University Hospital, Jerusalem, Israel
Diabetes Metab Res Rev 22:126-30. 2006..Epidemiological studies demonstrated that the two categories define distinct populations. In this study, we examined the contributions of insulin resistance and beta-cell dysfunction to both states in overweight subjects of Arab origin... - Early use of insulin in type 2 diabetesRoy Eldor
Diabetes Research Center, Department of Medicine, Hadassah Hebrew University Hospital, Jerusalem 91120, Israel
Diabetes Res Clin Pract 68:S30-5. 2005..This new approach, its rationale, benefits and misgivings are discussed in this review... - Association of hyperglycemia and insulin with diabetic cardiovascular complicationsMogher Khamaisi
Diabetes Center, Department of Internal Medicine, Hadassah University Hospital, Jerusalem, Israel
Isr Med Assoc J 5:116-9. 2003.... - Noninvasive continuous glucose monitoring using photoacoustic technology-results from the first 62 subjectsRam Weiss
The Diabetes Unit, Hadassah Hebrew University Hospital, Jerusalem, Israel
Diabetes Technol Ther 9:68-74. 2007..Continuous glucose monitoring is a useful tool for the achievement of improved glucose control in patients with diabetes. We tested the ability of a novel noninvasive continuous glucose monitor to track glucose excursions... - Innovative immune-based therapeutic approaches for the treatment of type 1 diabetes mellitusRoy Eldor
Diabetes Research Center, Department of Medicine, Hadassah Hebrew University Hospital, Jerusalem, Israel
Int Rev Immunol 24:327-39. 2005..Here we review the most promising therapies developed based on these targets and emphasize those that have reached human phase clinical investigation... - Increased expression of endothelin-converting enzyme-1c isoform in response to high glucose levels in endothelial cellsShoshana Keynan
Diabetes Center and Department of Internal Medicine, Hadassah University Hospital, Jerusalem, Israel
J Vasc Res 41:131-40. 2004..The main isoform to increase in response to high glucose was ECE-1c. This enzyme may be one of the factors contributing to the elevated ET-1 peptide levels observed in diabetes... - Glucose tolerance factor extracted from yeast: oral insulin-mimetic and insulin-potentiating agent: in vivo and in vitro studiesSarah Weksler-Zangen
The Diabetes Unit, Department of Internal Medicine and The Hadassah Diabetes Center, Hadassah Hebrew University Medical Center, Jerusalem, Israel
Br J Nutr 108:875-82. 2012..It produces an insulin-like effect by acting on cellular signals downstream of the insulin receptor. These results demonstrate a potential source for a novel oral medication for diabetes... - Immune modulation for prevention of type 1 diabetes mellitusItamar Raz
Diabetes Research Center, Department of Medicine, Hadassah-Hebrew University Hospital, Jerusalem 91120, Israel
Trends Biotechnol 23:128-34. 2005..Here, we review the results of these trials... - Gender-specific care of diabetes mellitus: particular considerations in the management of diabetic womenAuryan Szalat
Department of Endocrinology and Metabolism, Hadassah Hebrew University Hospital, Jerusalem, Israel
Diabetes Obes Metab 10:1135-56. 2008..These gender-specific features of DM may offer a route to improved care for women and new therapeutic possibilities... - Pharmacokinetic-pharmacodynamic analysis of the glucose-lowering effect of metformin in diabetic rats reveals first-pass pharmacodynamic effectDavid Stepensky
Department of Pharmaceutics, School of Pharmacy, The Hebrew University of Jerusalem, Jerusalem, Israel
Drug Metab Dispos 30:861-8. 2002.... - Reproducibility of glucose measurements using the glucose sensorMuriel Metzger
Diabetes Center, Endocrinology and Metabolism Service, Hadassah University Hospital, Jerusalem, Israel
Diabetes Care 25:1185-91. 2002..Its use is currently limited to the health care team. Our aim was to evaluate the reproducibility of data provided by the device by comparing data provided by two sensors worn simultaneously by the same subject... - Cannabidiol arrests onset of autoimmune diabetes in NOD miceLola Weiss
Department of Bone Marrow Transplantation and Cancer Immunotherapy, Hadassah Hebrew University Hospital, Jerusalem 91120, Israel
Neuropharmacology 54:244-9. 2008..Our data strengthen our previous assumption that CBD, known to be safe in man, can possibly be used as a therapeutic agent for treatment of type 1 diabetes... - Insulin-induced hypertension, L-arginine, and endothelial nitric oxide synthase in pregnant ratsMichael Bursztyn
Department of Medicine, Hadassah University Hospital, Mount Scorpus, Jerusalem, Israel
Hypertens Pregnancy 22:267-74. 2003..8 +/- 2.3, p < 0.03. Thus, the salutary effect of l-arginine on hyperinsulinemic pregnancy-induced hypertension (PIH) may be mediated, in part, by endothelial nitric oxide synthase in their kidneys... - Focus on childhood fitness, not just fatnessRam Weiss
Department of Pediatrics, Hadassah Hebrew University Hospital, Jerusalem, Israel
Lancet 368:261-2. 2006 - Possible association between diabetes and bisphosphonate-related jaw osteonecrosisMogher Khamaisi
Department of Internal Medicine B and the Diabetes Center, Hebrew University Hadassah Medical Center, Kiryat Hadassah, P O Box 12000, Jerusalem 91120, Israel
J Clin Endocrinol Metab 92:1172-5. 2007..Bisphosphonate-related osteonecrosis (BON) of the jaws is a newly identified condition for which the exact mechanism involved in its pathogenesis remains obscure... - The role of sulodexide in the treatment of diabetic nephropathyRam Weiss
Diabetes Center, Hadassah Hebrew University School of Medicine, Jerusalem, Israel
Drugs 67:2681-96. 2007.... - Sitagliptin: a viewpoint by Itamar RazItamar Raz
Diabetes Unit, Hadassah University Hospital, Jerusalem, Israel
Drugs 67:598-9. 2007 - Effect of short-term hyperglycemia on protein kinase C alpha activation in human erythrocytesLeonid Livshits
The Diabetes Research Center, Hadassah Hebrew University Medical Center, Jerusalem, Israel
Rev Diabet Stud 9:94-103. 2012..Protein kinase C alpha (PKCĪ±) is a major regulator of many metabolic processes and structural changes in erythrocytes, and may play a significant role in the development of hyperglycemia-mediated cellular abnormalities... - Diabetes therapy--focus on Asia: second-line therapy debate: insulin/secretagoguesRoy Eldor
Division of Diabetes and The Endocrinology Service, Department of Medicine, Hadassah Hebrew University Medical Center, Jerusalem, Israel
Diabetes Metab Res Rev 28:85-9. 2012..It is important to emphasize that regardless of it being a review of published evidence, it primarily represents the professional opinion of the writers... - Gender-specific care of diabetesAuryan Szalat
Hadassah Hebrew University Hospital, Internal Medicine, Endocrinology and Metabolism, Jerusalem, Israel
Womens Health (Lond Engl) 3:735-64. 2007.... - The Individualized Target HbA1c: A New Method for Improving Macrovascular Risk and Glycemia Without Hypoglycemia and Weight GainRoy Eldor
Diabetes Research Center, Department of Medicine, Hadassah Hebrew University Hospital, Jerusalem 91120, Israel
Rev Diabet Stud 6:6-12. 2009..Using our newly suggested system, a physician will first calculate the adequate HbA1c goal for his patient and then choose the drug that will best suit him, thus tailoring the treatment to the patients needs...