M Paul

Summary

Country: Israel

Publications

  1. ncbi request reprint The epidemiology of bacteremia with febrile neutropenia: experience from a single center, 1988-2004
    Mical Paul
    Department of Medicine E, Rabin Medical Center Beilinson Campus, Petah Tikva, Israel
    Isr Med Assoc J 9:424-9. 2007
  2. ncbi request reprint Improving empirical antibiotic treatment using TREAT, a computerized decision support system: cluster randomized trial
    Mical Paul
    Department of Medicine E, Rabin Medical Center, Beilinson Campus, 49100 Petah Tiqva, Israel
    J Antimicrob Chemother 58:1238-45. 2006
  3. ncbi request reprint Empirical antibiotics against Gram-positive infections for febrile neutropenia: systematic review and meta-analysis of randomized controlled trials
    Mical Paul
    Department of Medicine E, Rabin Medical Center, Beilinson Campus, 49100 Petah Tiqva
    J Antimicrob Chemother 55:436-44. 2005
  4. ncbi request reprint Acinetobacter baumannii: emergence and spread in Israeli hospitals 1997-2002
    M Paul
    Department of Medicine and Infectious Diseases, Rabin Medical Centre, Beilinson Campus, Petach Tikva, Israel Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    J Hosp Infect 60:256-60. 2005
  5. ncbi request reprint Empirical antibiotic monotherapy for febrile neutropenia: systematic review and meta-analysis of randomized controlled trials
    Mical Paul
    Department of Medicine E, Rabin Medical Center, Beilinson Campus, 49100 Petah Tiqva, Israel
    J Antimicrob Chemother 57:176-89. 2006
  6. ncbi request reprint The anti-cancer effects of quinolone antibiotics?
    M Paul
    Department of Medicine E and Infectious Diseases Unit, Rabin Medical Center, Beilinson Hospital, Petah Tikva, 49100, Israel
    Eur J Clin Microbiol Infect Dis 26:825-31. 2007
  7. doi request reprint Duration of antibiotic prophylaxis for cardiac surgery: prospective observational study
    Mical Paul
    Unit of Infectious Diseases, Rabin Medical Center, Beilinson Hospital and Sackler Faculty of Medicine, Tel Aviv University, Petah Tikva, Israel
    J Infect 58:291-8. 2009
  8. ncbi request reprint Prediction of bacteremia using TREAT, a computerized decision-support system
    Mical Paul
    Department of Medicine E, Rabin Medical Center, Beilinson Campus, Petah Tikva, Israel
    Clin Infect Dis 42:1274-82. 2006
  9. doi request reprint Combination antimicrobial treatment versus monotherapy: the contribution of meta-analyses
    Mical Paul
    Unit of Infectious Diseases, Rabin Medical Center, Beilinson Campus, Petah Tikva, Israel
    Infect Dis Clin North Am 23:277-93. 2009
  10. doi request reprint On transparency, responsibility, and accountability
    M Paul
    Infectious Diseases Unit, Rabin Medical Centre, Beilinson Hospital, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    Clin Microbiol Infect 15:1100-2. 2009

Collaborators

Detail Information

Publications43

  1. ncbi request reprint The epidemiology of bacteremia with febrile neutropenia: experience from a single center, 1988-2004
    Mical Paul
    Department of Medicine E, Rabin Medical Center Beilinson Campus, Petah Tikva, Israel
    Isr Med Assoc J 9:424-9. 2007
    ..The epidemiology of bacteremic febrile neutropenia differs between locations and constitutes the basis for selection of empiric antibiotic therapy for febrile neutropenia...
  2. ncbi request reprint Improving empirical antibiotic treatment using TREAT, a computerized decision support system: cluster randomized trial
    Mical Paul
    Department of Medicine E, Rabin Medical Center, Beilinson Campus, 49100 Petah Tiqva, Israel
    J Antimicrob Chemother 58:1238-45. 2006
    ..Appropriate antibiotic treatment decreases mortality, while superfluous treatment is associated with antibiotic resistance. We built a computerized decision support system for antibiotic treatment (TREAT) targeting these outcomes...
  3. ncbi request reprint Empirical antibiotics against Gram-positive infections for febrile neutropenia: systematic review and meta-analysis of randomized controlled trials
    Mical Paul
    Department of Medicine E, Rabin Medical Center, Beilinson Campus, 49100 Petah Tiqva
    J Antimicrob Chemother 55:436-44. 2005
    ..To assess the value of empirical anti-Gram-positive antibiotics for the treatment of febrile neutropenia...
  4. ncbi request reprint Acinetobacter baumannii: emergence and spread in Israeli hospitals 1997-2002
    M Paul
    Department of Medicine and Infectious Diseases, Rabin Medical Centre, Beilinson Campus, Petach Tikva, Israel Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    J Hosp Infect 60:256-60. 2005
    ..Multi-drug-resistant A. baumannii has the potential to reach endemicity in hospitals and warrants more vigorous and innovative efforts to limit its spread...
  5. ncbi request reprint Empirical antibiotic monotherapy for febrile neutropenia: systematic review and meta-analysis of randomized controlled trials
    Mical Paul
    Department of Medicine E, Rabin Medical Center, Beilinson Campus, 49100 Petah Tiqva, Israel
    J Antimicrob Chemother 57:176-89. 2006
    ..Early, empirical broad-spectrum antibiotic treatment is the established practice for febrile neutropenia. Several beta-lactams are accepted for monotherapy. We asked whether patients' outcomes are influenced by the chosen beta-lactam...
  6. ncbi request reprint The anti-cancer effects of quinolone antibiotics?
    M Paul
    Department of Medicine E and Infectious Diseases Unit, Rabin Medical Center, Beilinson Hospital, Petah Tikva, 49100, Israel
    Eur J Clin Microbiol Infect Dis 26:825-31. 2007
    ..93, 15 trials, 3,320 patients). This finding might represent biased attribution of deaths to infection or might be compatible with an anti-cancer effect of quinolone antibiotics. We present further analyses addressing these possibilities...
  7. doi request reprint Duration of antibiotic prophylaxis for cardiac surgery: prospective observational study
    Mical Paul
    Unit of Infectious Diseases, Rabin Medical Center, Beilinson Hospital and Sackler Faculty of Medicine, Tel Aviv University, Petah Tikva, Israel
    J Infect 58:291-8. 2009
    ..To assess the effect of prolonging antibiotic prophylaxis in cardiac surgery...
  8. ncbi request reprint Prediction of bacteremia using TREAT, a computerized decision-support system
    Mical Paul
    Department of Medicine E, Rabin Medical Center, Beilinson Campus, Petah Tikva, Israel
    Clin Infect Dis 42:1274-82. 2006
    ..Prediction of bloodstream infection at the time of sepsis onset allows one to make appropriate and economical management decisions...
  9. doi request reprint Combination antimicrobial treatment versus monotherapy: the contribution of meta-analyses
    Mical Paul
    Unit of Infectious Diseases, Rabin Medical Center, Beilinson Campus, Petah Tikva, Israel
    Infect Dis Clin North Am 23:277-93. 2009
    ....
  10. doi request reprint On transparency, responsibility, and accountability
    M Paul
    Infectious Diseases Unit, Rabin Medical Centre, Beilinson Hospital, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    Clin Microbiol Infect 15:1100-2. 2009
    ..We welcome transparent and appropriate authorship of industry-initiated randomized controlled trials with both positive and negative results...
  11. ncbi request reprint Sternal wound infection after coronary artery bypass graft surgery: validation of existing risk scores
    Mical Paul
    Department of Internal Medicine E, Rabin Medical Center, Beilinson Hospital and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    J Thorac Cardiovasc Surg 133:397-403. 2007
    ..Prediction of surgical site infection and mortality after cardiac surgery might allow for interventions to reduce adverse outcomes. We sought to evaluate existing risk scores...
  12. ncbi request reprint The significance of Acinetobacter baumannii bacteraemia compared with Klebsiella pneumoniae bacteraemia: risk factors and outcomes
    E Robenshtok
    Department of Medicine E, Rabin Medical Centre, Beilinson Campus, Petach Tikva, Israel
    J Hosp Infect 64:282-7. 2006
    ..e. those who were not ventilated and those who did not present with septic shock. These results support the view that nosocomial bacteraemia due to A. baumannii is associated with increased mortality...
  13. ncbi request reprint Persistent bacteremia in the absence of defined intravascular foci: clinical significance and risk factors
    M Y Chowers
    Sackler Faculty of Medicine, Tel Aviv University, Ramat Aviv, Tel Aviv, Israel
    Eur J Clin Microbiol Infect Dis 22:592-6. 2003
    ..Because of the high mortality associated with persistent bacteremia, a thorough search for the source of infection is essential to ensure timely and appropriate therapy...
  14. ncbi request reprint The need for macrolides in hospitalised community-acquired pneumonia: propensity analysis
    M Paul
    Department of Medicine E, Rabin Medical Center, Beilinson Hospital, 49100 Petah Tiqva, Israel
    Eur Respir J 30:525-31. 2007
    ..69 (95% confidence interval 0.32-1.48). The benefit of combination therapy versus monotherapy cannot be reliably assessed in observational studies, since the propensity to prescribe these regimens differs markedly...
  15. ncbi request reprint Excess mortality in women with hospital-acquired bloodstream infection
    L Leibovici
    Department of Medicine, Rabin Medical Center, Beilinson Campus, Petah-Tiqva, Israel
    Am J Med 111:120-5. 2001
    ..The excess mortality was concentrated in women with severe underlying disorders, suggesting that sepsis might have accentuated differences in the outcome of underlying disorders in women...
  16. pmc Monotherapy versus beta-lactam-aminoglycoside combination treatment for gram-negative bacteremia: a prospective, observational study
    L Leibovici
    Department of Medicine, Rabin Medical Center, Beilinson Campus, Petah Tiqva, Israel
    Antimicrob Agents Chemother 41:1127-33. 1997
    ..2; 95% CI, 0.05 to 0.7). In summary, combination treatment showed no advantage over treatment with an appropriate beta-lactam drug in nonneutropenic patients with gram-negative bacteremia...
  17. ncbi request reprint Departmental consumption of antibiotic drugs and subsequent resistance: a quantitative link
    L Leibovici
    Department of Medicine, Rabin Medical Center, Beilinson Campus, Petah Tiqva, Israel
    J Antimicrob Chemother 48:535-40. 2001
    ..To look for a quantitative model linking departmental consumption of antibiotic drugs to the subsequent isolation of resistant hospital-acquired coliform pathogens...
  18. doi request reprint Are all beta-lactams similarly effective in the treatment of methicillin-sensitive Staphylococcus aureus bacteraemia?
    M Paul
    Unit of Infectious Diseases, Rabin Medical Center, Beilinson Hospital, Petah Tikva, Israel
    Clin Microbiol Infect 17:1581-6. 2011
    ....
  19. ncbi request reprint Improving empirical antibiotic treatment: prospective, nonintervention testing of a decision support system
    L Leibovici
    Department of Medicine, Rabin Medical Centre, Beilinson Campus, Petah Tiqva, Israel
    J Intern Med 242:395-400. 1997
    ..Develop a problem-orientated and data-based decision support system (DSS) to improve empirical antibiotic treatment, and compare the performance of the system to that of the physician...
  20. ncbi request reprint Relative tachycardia in patients with sepsis: an independent risk factor for mortality
    L Leibovici
    Department of Medicine E, Rabin Medical Center, Beilinson Campus, and Sackler Faculty of Medicine, Petah Tiqva 49100, Tel Aviv University, Israel
    QJM 100:629-34. 2007
    ..Excess activation of the sympathetic nervous system may be a risk factor for mortality in patients with the systemic inflammatory response syndrome (SIRS) or sepsis...
  21. ncbi request reprint Antibiotic prophylaxis of bacterial infections in cirrhotic inpatients: a meta-analysis of randomized controlled trials
    K Soares-Weiser
    Dept of Medicine E, Beilinson Campus, Rabin Medical Center, Petah Tikva, Israel
    Scand J Gastroenterol 38:193-200. 2003
    ..We performed a systematic review to evaluate the efficacy of antibiotic prophylaxis in inpatients with cirrhosis, regardless of the underlying risk factors that led to hospital admission...
  22. doi request reprint Consequences of treated versus untreated asymptomatic bacteriuria in the first year following kidney transplantation: retrospective observational study
    H Green
    Department of Nephrology and Hypertension, Rabin Medical Center, Beilinson Campus, Petah Tikva 49100, Israel
    Eur J Clin Microbiol Infect Dis 32:127-31. 2013
    ..We observed no benefit for the antibiotic treatment of AB in the short- and long-term follow-up. A prospective observational study is needed...
  23. ncbi request reprint Behçet's disease in Israel: the influence of ethnic origin on disease expression and severity
    I Krause
    Department of Medicine E, Rabin Medical Center, Beilinson Campus, Sackler Faculty of Medicine, Tel Aviv University, Israel
    J Rheumatol 28:1033-6. 2001
    ..To evaluate the relationship between ethnic origin and manifestations of Behçet's disease (BD) in Israel...
  24. doi request reprint Macrolides vs. quinolones for community-acquired pneumonia: meta-analysis of randomized controlled trials
    K Skalsky
    Medicine E, Rabin Medical Center, Beilinson Hospital, Petah Tikva, Israel
    Clin Microbiol Infect 19:370-8. 2013
    ..The clinical significance of this advantage is unclear...
  25. ncbi request reprint Prophylactic use of antibiotics for prevention of meningococcal infections: systematic review and meta-analysis of randomised trials
    A Fraser
    Department of Medicine E, Rabin Medical Center, Beilinson Campus, Petah Tiqva, 49100, Israel
    Eur J Clin Microbiol Infect Dis 24:172-81. 2005
    ..Given that the use of rifampin in an outbreak setting might lead to the circulation of isolates resistant to rifampin, the use of ciprofloxacin and ceftriaxone should be considered...
  26. doi request reprint The effect of empiric antibiotic therapy on mortality in debilitated patients with dementia
    S Reisfeld
    Infectious Diseases Unit, Meir Medical Center, 59 Tsharnichovski St, Kfar Saba 44281, Israel
    Eur J Clin Microbiol Infect Dis 30:813-8. 2011
    ..Appropriate empirical antibiotic therapy for patients with dementia and severe bacterial infection did not have a clear advantage, especially in the sickest group of patients with decubitus ulcers...
  27. doi request reprint Extended-spectrum beta-lactamase-producing Enterobacteriaceae carriage upon hospital admission: prevalence and risk factors
    P Shitrit
    Infectious Diseases Unit, Meir Medical Centre, Kfar Saba, Israel Sackler Medical School, Tel Aviv University, Tel Aviv, Israel
    J Hosp Infect 85:230-2. 2013
    ..Over 50% of the screened patients had at least one risk factor. By screening this targeted population, 87.5% of positive patients would have been identified. ..
  28. doi request reprint Balancing the benefits and costs of antibiotic drugs: the TREAT model
    L Leibovici
    Department of Medicine E, Beilinson Hospital, Rabin Medical Center, Petah Tiqva, Israel
    Clin Microbiol Infect 16:1736-9. 2010
    ..the present, individual patient...
  29. ncbi request reprint Benefit of appropriate empirical antibiotic treatment: thirty-day mortality and duration of hospital stay
    Abigail Fraser
    Department of Medicine E, Rabin Medical Center, Beilinson Campus, Petah Tiqva, Israel
    Am J Med 119:970-6. 2006
    ..We evaluated the effect of inappropriate antibiotic treatment on mortality and duration of hospital stay in medical inpatients with bacterial infections...
  30. doi request reprint Cost-benefit of infection control interventions targeting methicillin-resistant Staphylococcus aureus in hospitals: systematic review
    L Farbman
    Medicine E, Rabin Medical Centre, Beilinson Hospital, Petah Tikva, Israel Leon Recanati Faculty of Management and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    Clin Microbiol Infect 19:E582-93. 2013
    ..This was true also for high MRSA endemicity settings. Unresolved economic issues include rapid screening using molecular techniques and universal versus targeted screening...
  31. doi request reprint Prevention of recurrent hepatitis B virus infection after liver transplantation: hepatitis B immunoglobulin, antiviral drugs, or both? Systematic review and meta-analysis
    L H Katz
    Liver Institute, Rabin Medical Center, Beilinson Hospital, Petach Tikva, Israel
    Transpl Infect Dis 12:292-308. 2010
    ..To evaluate antiviral prophylaxis against hepatitis B virus (HBV) following liver transplantation...
  32. ncbi request reprint The TREAT project: decision support and prediction using causal probabilistic networks
    Leonard Leibovici
    Department of Medicine E, Rabin Medical Center, Beilinson Campus, Petah Tiqva, Israel
    Int J Antimicrob Agents 30:S93-102. 2007
    ..In the present review we discuss the advantages of using causal probabilistic models for prediction and decision support, and the various decisions that were taken in the TREAT project...
  33. doi request reprint Systematic reviews and meta-analyses in infectious diseases: topics that merit special attention
    L Leibovici
    Department of Medicine E, Rabin Medical Centre, Beilinson Hospital, Petah Tiqva, Israel Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    Clin Microbiol Infect 20:101-4. 2014
    ..Resistance as an outcome is a topic that should be addressed in all SRs of antibiotic treatment. Ethical aspects and especially patients' safety should be addressed in SRs. ..
  34. doi request reprint Benchmarking inappropriate empirical antibiotic treatment
    G Kariv
    Department of Medicine E, Rabin Medical Centre, Beilinson Hospital, Petah Tikva, Israel
    Clin Microbiol Infect 19:629-33. 2013
    ..Based on the control limits found, at least 500 patients should be evaluated before establishing a local rate. Lower and higher than expected rates might indicate overly aggressive treatment or poor performance, respectively...
  35. doi request reprint Surgical site infections following craniotomy focusing on possible post-operative acquisition of infection: prospective cohort study
    O Sneh-Arbib
    Unit of Infectious Diseases, Rabin Medical Center, Beilinson Hospital, Petah Tikva, Israel
    Eur J Clin Microbiol Infect Dis 32:1511-6. 2013
    ..We raise the possibility of post-operative infection acquisition through external CSF devices. Standard operating procedures for their maintenance are necessary...
  36. doi request reprint Colistin: new lessons on an old antibiotic
    D Yahav
    Internal Medicine E, Rabin Medical Centre, Beilinson Hospital, Petah Tikva, Israel
    Clin Microbiol Infect 18:18-29. 2012
    ..Synergy with carbapenem, rifampin and other antibiotics has been reported in vitro. Randomized controlled trials are ongoing or in planning to assess this and other aspects of colistin use in clinical practice...
  37. ncbi request reprint Allelic distribution of HLA-B*5 in HLA-B5-positive Israeli patients with Behçet's disease
    M Paul
    Department of Medicine B, Rabin Medical Center, Beilinson Campus, Tel Aviv University, Tel Aviv, Israel
    Tissue Antigens 58:185-6. 2001
    ..The HLA-B*5201 allele was identified in all HLA-B52-positive patients and controls. Our study suggests that both HLA-B*5101 and HLA-B*5201 are the dominant alleles of HLA-B5 in Israeli BD patients...
  38. ncbi request reprint Soluble triggering receptor expressed on myeloid cells-1 for distinguishing bacterial from aseptic meningitis in adults
    J Bishara
    Infectious Diseases Unit, Rabin Medical Center, Beilinson Hospital, Petah Tiqwa, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    Eur J Clin Microbiol Infect Dis 26:647-50. 2007
    ..889. This suggests that sTREM-1 is upregulated in the CSF of patients with bacterial meningitis with high specificity and that its presence can potentially assist clinicians in the diagnosis of bacterial meningitis...
  39. ncbi request reprint Treatment of latent tuberculosis in persons at risk for multidrug-resistant tuberculosis: systematic review
    A Fraser
    Department of Medicine E, Beilinson Campus, Rabin Medical Center, Petah Tiqva 49100, Israel
    Int J Tuberc Lung Dis 10:19-23. 2006
    ..The emergence and spread of multidrug-resistant tuberculosis (MDR-TB), caused by Mycobacterium tuberculosis resistant to at least isoniazid (INH) and rifampicin, is a threat to global TB control...
  40. ncbi request reprint Prediction of specific pathogens in patients with sepsis: evaluation of TREAT, a computerized decision support system
    Mical Paul
    Department of Medicine E, Rabin Medical Center, Beilinson Campus, Petah Tiqva, Israel
    J Antimicrob Chemother 59:1204-7. 2007
    ..Prediction of bacterial infections and their pathogens allows for early, directed investigation and treatment. We assessed the ability of TREAT, a computerized decision support system, to predict specific pathogens...
  41. doi request reprint Prophylaxis regimens for GVHD: systematic review and meta-analysis
    R Ram
    Institute of Hematology, Davidoff Center Rabin Medical Center, Beilinson Hospital, Petah Tiqva, Israel
    Bone Marrow Transplant 43:643-53. 2009
    ..The addition of steroids did not affect the outcomes (four trials). We conclude that MTX-CsA and MTX-tacrolimus are both acceptable alternatives for GVHD prophylaxis, although MTX-tacrolimus may be superior in terms of aGVHD reduction...
  42. pmc Evidence based case report. Antibiotic treatment for spontaneous bacterial peritonitis
    K Soares-Weiser
    Department of Medicine E, Rabin Medical Center, Petah Tikva, Israel
    BMJ 324:100-2. 2002
  43. doi request reprint Nucleoside reverse transcriptase inhibitors in combination therapy for HIV patients: systematic review and meta-analysis
    M Chowers
    Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    Eur J Clin Microbiol Infect Dis 29:779-86. 2010
    ..This combination, soon to be generic, should be compared to the current standard of care in a large randomized trial. An effective, safe, and inexpensive alternative to current options is needed...