Anat Mirelman

Summary

Country: Israel

Publications

  1. doi request reprint Virtual reality for gait training: can it induce motor learning to enhance complex walking and reduce fall risk in patients with Parkinson's disease?
    Anat Mirelman
    Movement Disorders Unit, Department of Neurology, Tel Aviv Sourasky Medical Center, Israel
    J Gerontol A Biol Sci Med Sci 66:234-40. 2011
  2. doi request reprint Neural correlates of executive functions in healthy G2019S LRRK2 mutation carriers
    Avner Thaler
    Movement Disorders Unit, Department of Neurology, Tel Aviv Sourasky Medical Center, Israel Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel Electronic address
    Cortex 49:2501-11. 2013
  3. pmc Increased frontal brain activation during walking while dual tasking: an fNIRS study in healthy young adults
    Anat Mirelman
    Movement Disorders Unit, Department of Neurology, Tel Aviv Sourasky Medical Center, 6 Weizmann Street, Tel Aviv 64239, Israel
    J Neuroeng Rehabil 11:85. 2014
  4. pmc V-TIME: a treadmill training program augmented by virtual reality to decrease fall risk in older adults: study design of a randomized controlled trial
    Anat Mirelman
    Department of Neurology, Laboratory for Gait Analysis and Neurodynamics, Movement Disorders Unit, Tel Aviv Sourasky Medical Center, 6 Weizmann Street, Tel Aviv 64239, Israel
    BMC Neurol 13:15. 2013
  5. pmc Audio-biofeedback training for posture and balance in patients with Parkinson's disease
    Anat Mirelman
    Laboratory for Gait and Neurodynamics, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
    J Neuroeng Rehabil 8:35. 2011
  6. doi request reprint Gait alterations in healthy carriers of the LRRK2 G2019S mutation
    Anat Mirelman
    Movement Disorders Unit, Department of NeurologyTel Aviv Sourasky Medical Center, Tel Aviv, Israel
    Ann Neurol 69:193-7. 2011
  7. doi request reprint Effects of virtual reality training on gait biomechanics of individuals post-stroke
    Anat Mirelman
    Gait and Neurodynamics Laboratory, Tel Aviv Sourasky Medical Center, Israel
    Gait Posture 31:433-7. 2010
  8. doi request reprint Fall risk and gait in Parkinson's disease: the role of the LRRK2 G2019S mutation
    Anat Mirelman
    Movement Disorders Unit, Department of Neurology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel School of Health Related Professions, Ben Gurion University, Beer Sheba, Israel
    Mov Disord 28:1683-90. 2013
  9. pmc Lower cognitive performance in healthy G2019S LRRK2 mutation carriers
    Avner Thaler
    Movement Disorders Unit, Department of Neurology, Tel Aviv Sourasky Medical Center, Israel
    Neurology 79:1027-32. 2012
  10. doi request reprint Nonmotor symptoms in healthy Ashkenazi Jewish carriers of the G2019S mutation in the LRRK2 gene
    Anat Mirelman
    Movement Disorders Unit, Department of Neurology, Tel Aviv Medical Center, Department of Neurology, Israel
    Mov Disord 30:981-6. 2015

Collaborators

Detail Information

Publications33

  1. doi request reprint Virtual reality for gait training: can it induce motor learning to enhance complex walking and reduce fall risk in patients with Parkinson's disease?
    Anat Mirelman
    Movement Disorders Unit, Department of Neurology, Tel Aviv Sourasky Medical Center, Israel
    J Gerontol A Biol Sci Med Sci 66:234-40. 2011
    ..We hypothesized that VR may be applied to address the multifaceted deficits associated with fall risk in PD...
  2. doi request reprint Neural correlates of executive functions in healthy G2019S LRRK2 mutation carriers
    Avner Thaler
    Movement Disorders Unit, Department of Neurology, Tel Aviv Sourasky Medical Center, Israel Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel Electronic address
    Cortex 49:2501-11. 2013
    ....
  3. pmc Increased frontal brain activation during walking while dual tasking: an fNIRS study in healthy young adults
    Anat Mirelman
    Movement Disorders Unit, Department of Neurology, Tel Aviv Sourasky Medical Center, 6 Weizmann Street, Tel Aviv 64239, Israel
    J Neuroeng Rehabil 11:85. 2014
    ..The aim of this study was to investigate whether an increase in frontal activation is specific to dual tasking during walking...
  4. pmc V-TIME: a treadmill training program augmented by virtual reality to decrease fall risk in older adults: study design of a randomized controlled trial
    Anat Mirelman
    Department of Neurology, Laboratory for Gait Analysis and Neurodynamics, Movement Disorders Unit, Tel Aviv Sourasky Medical Center, 6 Weizmann Street, Tel Aviv 64239, Israel
    BMC Neurol 13:15. 2013
    ..The proposed randomized controlled trial will evaluate the effects of treadmill training augmented with virtual reality on fall risk...
  5. pmc Audio-biofeedback training for posture and balance in patients with Parkinson's disease
    Anat Mirelman
    Laboratory for Gait and Neurodynamics, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
    J Neuroeng Rehabil 8:35. 2011
    ..Based on the observation that postural control improved in patients with vestibular dysfunction after audio-biofeedback training, we tested the feasibility and effects of this training modality in patients with PD...
  6. doi request reprint Gait alterations in healthy carriers of the LRRK2 G2019S mutation
    Anat Mirelman
    Movement Disorders Unit, Department of NeurologyTel Aviv Sourasky Medical Center, Tel Aviv, Israel
    Ann Neurol 69:193-7. 2011
    ..These findings support the possibility of previously unidentified, presymptomatic motor changes among relatives who have an increased risk of developing PD...
  7. doi request reprint Effects of virtual reality training on gait biomechanics of individuals post-stroke
    Anat Mirelman
    Gait and Neurodynamics Laboratory, Tel Aviv Sourasky Medical Center, Israel
    Gait Posture 31:433-7. 2010
    ..To evaluate gait biomechanics after training with a virtual reality (VR) system and to elucidate underlying mechanisms that contributed to the observed functional improvement in gait speed and distance...
  8. doi request reprint Fall risk and gait in Parkinson's disease: the role of the LRRK2 G2019S mutation
    Anat Mirelman
    Movement Disorders Unit, Department of Neurology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel School of Health Related Professions, Ben Gurion University, Beer Sheba, Israel
    Mov Disord 28:1683-90. 2013
    ..Therapeutic approach specifically designed to delay gait disturbances and falls may be justified in patients who carry the G2019S mutation...
  9. pmc Lower cognitive performance in healthy G2019S LRRK2 mutation carriers
    Avner Thaler
    Movement Disorders Unit, Department of Neurology, Tel Aviv Sourasky Medical Center, Israel
    Neurology 79:1027-32. 2012
    ..To assess cognitive abilities of healthy first-degree relatives of Ashkenazi patients with Parkinson disease (PD), carriers of the G2019S mutation in the LRRK2 gene...
  10. doi request reprint Nonmotor symptoms in healthy Ashkenazi Jewish carriers of the G2019S mutation in the LRRK2 gene
    Anat Mirelman
    Movement Disorders Unit, Department of Neurology, Tel Aviv Medical Center, Department of Neurology, Israel
    Mov Disord 30:981-6. 2015
    ..The aim of this study was to assess differences in nonmotor symptoms between nonmanifesting carriers and noncarriers of the G2019S mutation...
  11. doi request reprint The age at motor symptoms onset in LRRK2-associated Parkinson's disease is affected by a variation in the MAPT locus: a possible interaction
    Ziv Gan-Or
    The Genetic Institute, Tel Aviv Sourasky Medical Center, 6 Weizmann Street, Tel Aviv, 64239, Israel
    J Mol Neurosci 46:541-4. 2012
    ..7 ± 11.6) among carriers of the C/C genotype (p = 0.025). Our results further support a possible interaction between genetic factors in the MAPT region and the LRRK2 gene, which influence the clinical course of PD patients...
  12. doi request reprint A voxel-based morphometry and diffusion tensor imaging analysis of asymptomatic Parkinson's disease-related G2019S LRRK2 mutation carriers
    Avner Thaler
    Movement Disorders Unit, Department of Neurology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel Sackler School of Medicine, Sagol School for Neuroscience, Tel Aviv University, Tel Aviv, Israel
    Mov Disord 29:823-7. 2014
    ..Patients with Parkinson's disease have reduced gray matter volume and fractional anisotropy in both cortical and sub-cortical structures, yet changes in the pre-motor phase of the disease are unknown...
  13. pmc Association between performance on Timed Up and Go subtasks and mild cognitive impairment: further insights into the links between cognitive and motor function
    Anat Mirelman
    Laboratory for Gait and Neurodynamics, Movement Disorders Unit, Department of Neurology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel School of Health Related Professions, Ben Gurion University, Beer Sheba, Israel
    J Am Geriatr Soc 62:673-8. 2014
    ..To assess whether different Timed Up and Go (TUG) subtasks are affected differently in older adults with mild cognitive impairment (MCI) and are specific to different cognitive abilities...
  14. pmc Executive control deficits as a prodrome to falls in healthy older adults: a prospective study linking thinking, walking, and falling
    Talia Herman
    Movement Disorders Unit, Department of Neurology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
    J Gerontol A Biol Sci Med Sci 65:1086-92. 2010
    ..Indeed, the effects of dual tasking (DT) on gait, a challenge to executive control, are more exaggerated in persons with a history of falls. Prospective evidence is, however, lacking...
  15. doi request reprint Intact working memory in non-manifesting LRRK2 carriers - an fMRI study
    Avner Thaler
    Movement Disorders Unit, Department of Neurology, Tel Aviv Sourasky Medical Center, 6 Weizman Street, Tel Aviv, 64239, Israel
    Eur J Neurosci 43:106-12. 2016
    ..These finding shed light on the pre-motor cognitive changes in this unique 'at risk' population and should enable more focused cognitive assessments of these cohorts. ..
  16. pmc How does explicit prioritization alter walking during dual-task performance? Effects of age and sex on gait speed and variability
    Galit Yogev-Seligmann
    Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    Phys Ther 90:177-86. 2010
    ..Previous studies have demonstrated that the performance of a secondary task during walking alters gait...
  17. pmc Executive function and falls in older adults: new findings from a five-year prospective study link fall risk to cognition
    Anat Mirelman
    Movement Disorders Unit, Department of Neurology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
    PLoS ONE 7:e40297. 2012
    ..Secondary objectives were to assess whether single and dual task walking abilities, an alternative window into EF, were associated with fall risk...
  18. doi request reprint Association of sequence alterations in the putative promoter of RAB7L1 with a reduced parkinson disease risk
    Ziv Gan-Or
    Genetic Institute, Tel Aviv Sourasky Medical Center, 6 Weizmann St, Tel Aviv 64239, Israel
    Arch Neurol 69:105-10. 2012
    ....
  19. doi request reprint Fighting the risk of developing Parkinson's disease; clinical counseling for first degree relatives of patients with Parkinson's disease
    Nir Giladi
    Movement Disorders Unit, Department of Neurology, Tel Aviv University, Tel Aviv, Israel
    J Neurol Sci 310:17-20. 2011
    ..In Israel, there is a large group of Ashkenazi Jews at risk of developing PD due to high frequency of PD associated mutations in 2 genes (GBA and LRRK2)...
  20. doi request reprint Effects of training with a robot-virtual reality system compared with a robot alone on the gait of individuals after stroke
    Anat Mirelman
    Gait and Neurodynamics Lab, Tel Aviv Medical Center, 6 Weizmann St, Tel Aviv, Israel
    Stroke 40:169-74. 2009
    ..The purpose of this study was to determine whether the transfer of training of LE movements to locomotion was greater using a virtual environment coupled with a robot or with the robot alone...
  21. pmc Heart rate changes during freezing of gait in patients with Parkinson's disease
    Inbal Maidan
    Movement Disorders Unit, Department of Neurology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
    Mov Disord 25:2346-54. 2010
    ..Although further studies are needed to evaluate these associations, the current results provide experimental evidence linking impaired motor blockades to autonomic nervous system function among patients with PD...
  22. doi request reprint Effects of Aging on Arm Swing during Gait: The Role of Gait Speed and Dual Tasking
    Anat Mirelman
    Center for the Study of Movement, Cognition and Mobility, Department of Neurology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel Department of Neurology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    PLoS ONE 10:e0136043. 2015
    ..Follow-up work is needed to examine if these effects contribute to reduced stability in aging. ..
  23. doi request reprint Fall risk is associated with amplified functional connectivity of the central executive network in patients with Parkinson's disease
    Keren Rosenberg-Katz
    Department of Neurology, Center for the Study of Movement, Cognition, and Mobility, Tel Aviv Sourasky Medical Center, 6 Weizmann Street, 64239, Tel Aviv, Israel
    J Neurol 262:2448-56. 2015
    ..The above findings provide additional converging evidence for the involvement of executive-related brain changes in falls in PD and support the important role of attention and executive function in fall risk...
  24. doi request reprint Clinical experience using a 5-week treadmill training program with virtual reality to enhance gait in an ambulatory physical therapy service
    Shirley Roth Shema
    S R Shema, BPT, Movement Disorders Unit, Department of Neurology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
    Phys Ther 94:1319-26. 2014
    ..Recently, VR was used to develop an adjunct training method for use by physical therapists in an ambulatory clinical setting...
  25. doi request reprint Dual-task training on a treadmill to improve gait and cognitive function in elderly idiopathic fallers
    Moran Dorfman
    Laboratory for Gait and Neurodynamics, Movement Disorders Unit, Department of Neurology, The Tel Aviv Sourasky Medical Center, Tel Aviv, Israel M D, T H, M B, S S, A W, J M H, A M School of Health Related Professions, Ben Gurion University, Beer Sheba, Israel M D Department of Physical Therapy, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel J M H Harvard Medical School, Boston, Massachusetts J M H and Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel J M H
    J Neurol Phys Ther 38:246-53. 2014
    ..The aim of this study was to assess whether a combined intervention, consisting of treadmill training (TT) while performing DT, improves cognitive and motor performance in older adults with a history of multiple falls...
  26. doi request reprint Appreciation of humor is decreased among patients with Parkinson's disease
    Avner Thaler
    Movement Disorders Unit, Department of Neurology, Tel Aviv Medical Center, Sackler School of Medicine, Tel Aviv University, 6 Weizman Street, Tel Aviv 64239, Israel
    Parkinsonism Relat Disord 18:144-8. 2012
    ..To test whether appreciation of humor might be a non-motor function affected by Parkinson's disease (PD)...
  27. pmc Age-specific penetrance of LRRK2 G2019S in the Michael J. Fox Ashkenazi Jewish LRRK2 Consortium
    Karen Marder
    From the Departments of Neurology K M, R N A, H M S, M X T and Pathology and Cell Biology L C, and Center for Human Genetics L C, College of Physicians and Surgeons, Columbia University Taub Institute for Research on Alzheimer s Disease and the Aging Brain K M, R N A, M X T, L C and Department of Biostatistics, Mailman School of Public Health Y W, A L, Columbia University, New York The Alan and Barbara Mirken Department of Neurology D R, R S P, S B, Beth Israel Medical Center, New York, NY Movement Disorders Unit, Department of Neurology, Tel Aviv Medical Center A M, N G, Sackler School of Medicine A O U, and Sagol School for Neurosciences A M, N G, Tel Aviv University School of Health Related Professions A M, Ben Gurion University, Beer Sheba, Israel Departments of Genetics and Genomic Sciences and Neurology L O, Mount Sinai School of Medicine, New York, NY and Genetics Institute A O U, Tel Aviv Sourasky Medical Center, Israel
    Neurology 85:89-95. 2015
    ..Estimates of the penetrance of LRRK2 G2019S vary widely (24%-100%), reflective of differences in ascertainment, age, sex, ethnic group, and genetic and environmental modifiers...
  28. doi request reprint Changes in oxygenated hemoglobin link freezing of gait to frontal activation in patients with Parkinson disease: an fNIRS study of transient motor-cognitive failures
    Inbal Maidan
    Center for the Study of Movement, Cognition and Mobility, Department of Neurology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
    J Neurol 262:899-908. 2015
    ..These results support the idea that alterations in executive control play a role in this debilitating motor disturbance...
  29. pmc Using a body-fixed sensor to identify subclinical gait difficulties in older adults with IADL disability: maximizing the output of the timed up and go
    Aner Weiss
    Laboratory for Gait and Neurodynamics, Movement Disorders Unit, Department of Neurology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
    PLoS ONE 8:e68885. 2013
    ..We tested whether measures derived from a single body-fixed sensor worn during traditional Timed Up and Go (TUG) testing could identify subclinical gait impairments in community dwelling older adults without mobility disability...
  30. pmc Automated detection of missteps during community ambulation in patients with Parkinson's disease: a new approach for quantifying fall risk in the community setting
    Tal Iluz
    Laboratory for Gait and Neurodynamics, Movement Disorders Unit, Department of Neurology, Tel Aviv Sourasky Medical Center, 6 Weizman Street, Tel Aviv 64239, Israel
    J Neuroeng Rehabil 11:48. 2014
    ..We developed an objective tool for detecting missteps under real-world, daily life conditions to enhance the evaluation of fall risk and applied this new method to 3 day continuous recordings...
  31. pmc When does walking alter thinking? Age and task associated findings
    Jennifer M Srygley
    Movement Disorders Unit, Department of Neurology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
    Brain Res 1253:92-9. 2009
    ..Age-associated declines in EF apparently contribute to the difference in dual tasking abilities during walking between young and older adults...
  32. pmc The p.L302P mutation in the lysosomal enzyme gene SMPD1 is a risk factor for Parkinson disease
    Ziv Gan-Or
    Genetic Institute and Movement Disorders Unit, Parkinson Center, Department of Neurology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
    Neurology 80:1606-10. 2013
    ..To study the possible association of founder mutations in the lysosomal storage disorder genes HEXA, SMPD1, and MCOLN1 (causing Tay-Sachs, Niemann-Pick A, and mucolipidosis type IV diseases, respectively) with Parkinson disease (PD)...
  33. doi request reprint Virtual reality and motor imagery: promising tools for assessment and therapy in Parkinson's disease
    Anat Mirelman
    Movement Disorders Unit, Department of Neurology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel School of Health Related Professions, Ben Gurion University, Beer Sheba, Israel
    Mov Disord 28:1597-608. 2013
    ..The possible mechanisms underlying MI and VR and recommendations for future research and therapy are also presented...