Research Topics
Species | Yechiel LevkovitzSummaryCountry: Israel Publications
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Publications
Minocycline, a second-generation tetracycline, as a neuroprotective agent in an animal model of schizophreniaYechiel Levkovitz
The Emotion Cognition Research Center, The Shalvata Mental Health Care Center, P O B 94 Hod Hasharon, Israel
Brain Res 1154:154-62. 2007..The discussion addresses potential mechanisms underlying the effects of minocycline and possible directions for future research...- Antidepressants induce cellular insulin resistance by activation of IRS-1 kinasesYechiel Levkovitz
Laboratory of Biological Psychiatry, Felsenstein Medical Research Center, Rabin Campus, Petah Tiqva, Israel
Mol Cell Neurosci 36:305-12. 2007..These results implicate selected SSRIs as inhibitors of insulin signaling and as potential inducers of cellular insulin resistance... 
A double-blind, randomized study of minocycline for the treatment of negative and cognitive symptoms in early-phase schizophreniaYechiel Levkovitz
The Emotion Cognition Research Center, The Shalvata Mental Health Care Center, P O B 94 Hod Hasharon, Israel
J Clin Psychiatry 71:138-49. 2010..Other proposed mechanisms of action include effects of minocycline on the dopaminergic system and its inhibition of microglial activation...- Differential induction of apoptosis by antidepressants in glioma and neuroblastoma cell lines: evidence for p-c-Jun, cytochrome c, and caspase-3 involvementYechiel Levkovitz
Laboratory of Biological Psychiatry, Felsenstein Medical Research Center, Tel Aviv University, Rabin Campus, Petah Tiqva 49100, Israel
J Mol Neurosci 27:29-42. 2005..The high sensitivity to these drugs of the cancer cell, compared with primary brain tissue, suggests the potential use of these agents in the treatment of brain-derived tumors... - Deep transcranial magnetic stimulation add-on for treatment of negative symptoms and cognitive deficits of schizophrenia: a feasibility studyYechiel Levkovitz
The Emotion Cognition Research Center, Shalvata Mental Health Care Center, Hod Hasharon, Israel, affiliated to the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
Int J Neuropsychopharmacol 14:991-6. 2011..The effect of 20 daily deep-TMS sessions (20 Hz, 120% motor threshold) over the prefrontal cortex of 15 patients indicated improvement in cognition and negative symptoms that was maintained at 2-wk post-treatment follow-up... - Characterization of phenothiazine-induced apoptosis in neuroblastoma and glioma cell lines: clinical relevance and possible application for brain-derived tumorsIrit Gil-Ad
Laboratory of Biological Psychiatry, Felsenstein Medical Research Center, Campus Rabin, Petah Tiqva 49100, Israel, and Sackler School of Medicine, Tel Aviv University, Ramat Aviv, Israel
J Mol Neurosci 22:189-98. 2004..Overall, the marked apoptotic effect of phenothiazines in brain-derived cancer cells, and the low sensitivity of primary brain tissue suggest the potential use of selected agents as therapeutic modalities in brain cancer... - Effect of L-tryptophan on memory in patients with schizophreniaYechiel Levkovitz
Shalvata Mental Health Center, Hod-Hasharon, affiliated with the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
J Nerv Ment Dis 191:568-73. 2003..These preliminary results suggest the possibility of using serotonin precursor to enhance memory function in schizophrenia... - Phenothiazines induce apoptosis in a B16 mouse melanoma cell line and attenuate in vivo melanoma tumor growthIrit Gil-Ad
Laboratory of Biological Psychiatry, Felsenstein Medical Research Center, Rabin Medical Center Beilinson Campus, Petah Tiqva, Israel
Oncol Rep 15:107-12. 2006..resulted in the reduction of lung tumor burden and an increase in mice survival. In conclusion, several phenothiazines, and particularly thioridazine, induced apoptosis of B16 melanoma cells and demonstrated in vivo anti-tumor activity... - H-coil repetitive transcranial magnetic stimulation for the treatment of bipolar depression: an add-on, safety and feasibility studyEiran Vadim Harel
The Emotion Cognition Research Center, Shalvata Mental Health Care Center, Hod Hasharon, Israel
World J Biol Psychiatry 12:119-26. 2011..This pilot study evaluated the safety and feasibility of the H1-Coil as adjuvant treatment for bipolar depression (BPD)... - Ultimatum bargaining behavior of people affected by schizophreniaNirit Agay
The Raymond and Beverly Sackler Faculty of Exact Sciences, School of Mathematical Sciences, Tel Aviv University, Ramat Aviv, Israel
Psychiatry Res 157:39-46. 2008..In contrast, as Responders, schizophrenic patients acted not significantly different from controls. Further investigation is needed to establish the links between cognitive and symptomatic mediators and strategic decision-making ability... - Double dissociation between cognitive and affective empathy in borderline personality disorderHagai Harari
The Emotion Cognition Research Center, Shalvata Mental Health Care Center, Hod Hasharon, Israel
Psychiatry Res 175:277-9. 2010..These results suggest that a dysfunctional pattern of empathic capacity may account for behavioral difficulties in BPD... - Repetitive transcranial magnetic stimulation in the treatment of depression in adolescents: an open-label studyYuval Bloch
Shalvata Mental Health Center, Hod Hasharon, Israel
J ECT 24:156-9. 2008..This open-label pilot study examined repetitive transcranial magnetic stimulation as a possible treatment of adolescent resistant depression... - Are psychotherapists consistent in their ethical attitude to patient confidentiality?Silvana Fennig
The Schneider Children s Medical Center of Israel, Beilinson Campus, Petach Tikva, Israel
Isr J Psychiatry Relat Sci 41:82-9. 2004..The issue of confidentiality often causes an ethical dilemma for the psychotherapist... - Understanding and knowledge of psychiatric treatment among adolescents and adultsIdo Lurie
Shalvata Mental Health Center, Shalvata Mental Health Center, Hod Hasharon, P O B 94, Israel
Clin Child Psychol Psychiatry 14:589-94. 2009..These data indicate that adolescents are no less knowledgeable than adults and should be regarded as competent partners in the process of therapeutic decision making... - Suicidal behavior in minors-diagnostic differences between children and adolescentsAriel Ben-Yehuda
The Emotion Cognition Research Center, Shalvata Mental Health Care Center, Hod Hasharon, Israel
J Dev Behav Pediatr 33:542-7. 2012..We hypothesized that suicidal behavior in children stems from a different diagnosis than suicidal behavior in adolescents, and thus merits its own investigation... - Executive functioning among patients with borderline personality disorder (BPD) and their relativesHila Z Gvirts
The Emotion Cognition Research Center, Shalvata Mental Health Care Center, Hod Hasharon, Israel, affiliated with the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
J Affect Disord 143:261-4. 2012..Thus, the aim of the present study was to investigate executive functions in both patients BPD and their unaffected first-degree relatives (parents)... - Assessment of negative symptoms and depression in schizophrenia: revision of the SANS and how it relates to the PANSS and CDSSLiron Rabany
The Emotion Cognition Research Center, Shalvata Mental Health Center, Hod Hasharon, Israel
Schizophr Res 126:226-30. 2011..The current study revised SANS's structure and examined its correlations with the PANSS and the CDSS... - Effectiveness and safety of adjunctive antidepressants in the treatment of bipolar depression: a reviewEiran Vadim Harel
Emotion Cognition Research Center, The Shalvata Mental Health Care Center, Hod Hasharon, Israel
Isr J Psychiatry Relat Sci 45:121-8. 2008.... - Lexical ambiguity resolution in Wernicke's area and its right homologueYuval Harpaz
Department of Psychology, Tel Aviv University, Tel Aviv, Israel
Cortex 45:1097-103. 2009.... - Gender differences in electroconvulsive therapy: a retrospective chart reviewYuval Bloch
Shalvata Mental Health Center, Hod Hasharon, P O Box 94, Israel, affiliated to the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
J Affect Disord 84:99-102. 2005..There is a growing interest in gender differences of different psychiatric disorders, especially major depression. We sought a possible gender difference related to electroconvulsive therapy (ECT)... - Ethical dilemmas in psychotherapy: comparison between patients, therapists and laypersonsSilvana Fennig
Sackler School of Medicine, Tel Aviv University, Ramat Aviv, Israel
Isr J Psychiatry Relat Sci 42:251-7. 2005..The attitudes of patients towards ethical dilemmas in psychotherapy have been reported in only a few studies... - Executive functioning during full and partial remission (positive and negative symptomatic remission) of schizophreniaYoram Braw
The Emotion Cognition Research Center, Shalvata Mental Health Center, Hod Hasharon, Israel Department of Behavioral Sciences, Ariel University Center of Samaria, Ariel, Israel
Schizophr Res 142:122-8. 2012..The current study therefore examined the executive functioning of patients in full symptomatic remission and for the first time assessed two sub-groups of patients in partial remission... - Reasons for referral for electroconvulsive therapy: a comparison between adolescents and adultsYuval Bloch
Child and adolescent out patient clinic, Shalvata Mental Health Center, Hod Hasharon, Israel
Australas Psychiatry 16:191-4. 2008..In order to improve our understanding of the use of electroconvulsive therapy (ECT) in adolescent patients, we aimed to evaluate the reasons for referral for ECT in different age groups... - The SSRIs drug Fluoxetine, but not the noradrenergic tricyclic drug Desipramine, improves memory performance during acute major depressionYechiel Levkovitz
Shalvata Mental Health Center, Hod Hasharon, Israel
Brain Res Bull 58:345-50. 2002..Furthermore, in cases where, for various reasons, the treatment of choice is noradrenergic, it may be worthwhile to consider a supplementary serotonergic drug to improve memory deficits... - Everyday memory and laboratory memory tests: general function predictors in schizophrenia and remitted depressionShumel Fennig
Shalvata Mental Health Center, Sackler School of Medicine, Tel Aviv University Ramat Aviv, P. O. Box 94, Hod Hasharon, Israel, 45100
J Nerv Ment Dis 190:677-82. 2002..However, the advantages of these tests over laboratory memory tests need to be further investigated in larger and more representative samples... - Learned irrelevance is disrupted in first-episode but not chronic schizophrenia patientsGilad Gal
Shalvata Mental Health Center, Hod Hasharon, P.O. Box 94, Israel
Behav Brain Res 159:267-75. 2005..In addition to the LIrr paradigm the same subjects were tested in a covert-orientation task. No differences were observed between the groups on this task. The possible advantages of the new LIrr paradigm are discussed... - Dissociation of cognitive from affective components of theory of mind in schizophreniaSimone G Shamay-Tsoory
Department of Psychology and Brain and Behavior Center, University of Haifa, Haifa 31905, Israel
Psychiatry Res 149:11-23. 2007..These findings offer new insight into the affective facets of social behavior that may underlie the profound behavioral disturbances observed in schizophrenia... - The neuroanatomical basis of affective mentalizing in schizophrenia: comparison of patients with schizophrenia and patients with localized prefrontal lesionsSimone G Shamay-Tsoory
Department of Psychology and Brain and Behavior Center, University of Haifa, Haifa, Israel
Schizophr Res 90:274-83. 2007.... - Neurocognitive basis of impaired empathy in schizophreniaSimone G Shamay-Tsoory
Department of PsychologyUniversity of Haifa, Haifa, Israel
Neuropsychology 21:431-8. 2007..However, while cognitive empathy was particularly related to measurements of orbitofrontal (rather than dorsolateral) functioning, affective empathy was related to measures of social functioning... 
Cognition in young schizophrenia outpatients: comparison of first-episode with multiepisode patientsYoram Braw
Shalvata Mental Health Center, Hod Hasharon, 45100 Israel
Schizophr Bull 34:544-54. 2008..These findings can help clarify the course of cognitive decline in young-aged SZ patients and aid in the development of phase-appropriate interventions...- A dominant negative Egr inhibitor blocks nerve growth factor-induced neurite outgrowth by suppressing c-Jun activation: role of an Egr/c-Jun complexYechiel Levkovitz
Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
J Neurosci 22:3845-54. 2002..Accordingly, our studies indicate that Egr and ZnEgr proteins regulate c-Jun activation via a novel mechanism, protein-protein interaction with c-Jun, rather than via their classical mode of action, binding to the ERE...