Arie Levine

Summary

Affiliation: Tel aviv University
Location: , Israel
Summary:
Chair Porto IBD group , ESPGHAN
Grants:
GROWTH(Growth,Relapse,Outcomes With THerapy )Crohns Disease Study, 2012,Thrasher Research Fund
Azithromycin for Treatment of Mild to Moderate Pediatric Crohns Disease, 2012, Broad Medical Research

Publications

  1. ncbi request reprint Pediatric onset Crohn's colitis is characterized by genotype-dependent age-related susceptibility
    Arie Levine
    Pediatric Gastroenterology Unit, Wolfson Medical Center and Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
    Inflamm Bowel Dis 13:1509-15. 2007
  2. ncbi request reprint Is age of onset of Crohn's disease governed by mutations in NOD2/caspase recruitment domains 15 and Toll-like receptor 4? Evaluation of a pediatric cohort
    Esther Leshinsky-Silver
    Molecular Genetics Laboratory, E Wolfson Medical Center, Holon, Holon, Israel
    Pediatr Res 58:499-504. 2005
  3. doi request reprint Screening criteria for diagnosis of infantile feeding disorders as a cause of poor feeding or food refusal
    Arie Levine
    Pediatric Gastroenterology and Nutrition Unit, Wolfson Medical Center, Tel Aviv University, Holon, Israel
    J Pediatr Gastroenterol Nutr 52:563-8. 2011
  4. doi request reprint Combined azithromycin and metronidazole therapy is effective in inducing remission in pediatric Crohn's disease
    Arie Levine
    Pediatric Gastroenterology and Nutrition Unit, Wolfson Medical Center, Tel Aviv University, Israel
    J Crohns Colitis 5:222-6. 2011
  5. doi request reprint Pediatric modification of the Montreal classification for inflammatory bowel disease: the Paris classification
    Arie Levine
    Wolfson Medical Center, Tel Aviv University, Israel
    Inflamm Bowel Dis 17:1314-21. 2011
  6. ncbi request reprint Diagnostic clues for identification of nonorganic vs organic causes of food refusal and poor feeding
    Yuval Levy
    Pediatric Gastroenterology Unit and Feeding Disorder Clinic, Wolfson Medical Center, Sackler School of Medicine, Tel Aviv University, Israel
    J Pediatr Gastroenterol Nutr 48:355-62. 2009
  7. doi request reprint Early-onset Crohn disease is associated with male sex and a polymorphism in the IL-6 promoter
    Keren Sagiv-Friedgut
    Pediatric Gastroenterology Unit, Wolfson Medical Center, Holon Sackler School of Medicine, Tel Aviv University, Israel
    J Pediatr Gastroenterol Nutr 50:22-6. 2010
  8. ncbi request reprint TNF promoter polymorphisms and modulation of growth retardation and disease severity in pediatric Crohn's disease
    Arie Levine
    Pediatric Gastroenterology and Nutrition Unit, E Wolfson Medical Center, Holon, Israel
    Am J Gastroenterol 100:1598-604. 2005
  9. ncbi request reprint Evaluation of the interleukin-23 receptor gene coding variant R381Q in pediatric and adult Crohn disease
    Esther Leshinsky-Silver
    Molecular Genetics Laboratory, Holon, Israel
    J Pediatr Gastroenterol Nutr 45:405-8. 2007
  10. doi request reprint Mathematical weighting of the pediatric Crohn's disease activity index (PCDAI) and comparison with its other short versions
    Dan Turner
    Pediatric Gastroenterology Unit, Shaare Zedek Medical Center, Hebrew University of Jerusalem, Israel
    Inflamm Bowel Dis 18:55-62. 2012

Detail Information

Publications48

  1. ncbi request reprint Pediatric onset Crohn's colitis is characterized by genotype-dependent age-related susceptibility
    Arie Levine
    Pediatric Gastroenterology Unit, Wolfson Medical Center and Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
    Inflamm Bowel Dis 13:1509-15. 2007
    ..Differences in disease site by age may suggest a different genotype, or different host responses such as decreased ileal susceptibility or increased susceptibility of the colon...
  2. ncbi request reprint Is age of onset of Crohn's disease governed by mutations in NOD2/caspase recruitment domains 15 and Toll-like receptor 4? Evaluation of a pediatric cohort
    Esther Leshinsky-Silver
    Molecular Genetics Laboratory, E Wolfson Medical Center, Holon, Holon, Israel
    Pediatr Res 58:499-504. 2005
    ..Mutations that are not in linkage disequilibrium with the background mutation P268S of the NOD2/CARD15 gene probably play a more significant role in pediatric-onset disease...
  3. doi request reprint Screening criteria for diagnosis of infantile feeding disorders as a cause of poor feeding or food refusal
    Arie Levine
    Pediatric Gastroenterology and Nutrition Unit, Wolfson Medical Center, Tel Aviv University, Holon, Israel
    J Pediatr Gastroenterol Nutr 52:563-8. 2011
    ....
  4. doi request reprint Combined azithromycin and metronidazole therapy is effective in inducing remission in pediatric Crohn's disease
    Arie Levine
    Pediatric Gastroenterology and Nutrition Unit, Wolfson Medical Center, Tel Aviv University, Israel
    J Crohns Colitis 5:222-6. 2011
    ..We aimed to assess whether azithromycin based therapy is effective in inducing remission in CD, due to its effect in inducing apoptosis and efficacy against biofilms and intracellular bacteria...
  5. doi request reprint Pediatric modification of the Montreal classification for inflammatory bowel disease: the Paris classification
    Arie Levine
    Wolfson Medical Center, Tel Aviv University, Israel
    Inflamm Bowel Dis 17:1314-21. 2011
    ..The dynamic features of pediatric disease phenotype (change in disease location and behavior over time, growth failure) are not sufficiently captured by the current Montreal Classification...
  6. ncbi request reprint Diagnostic clues for identification of nonorganic vs organic causes of food refusal and poor feeding
    Yuval Levy
    Pediatric Gastroenterology Unit and Feeding Disorder Clinic, Wolfson Medical Center, Sackler School of Medicine, Tel Aviv University, Israel
    J Pediatr Gastroenterol Nutr 48:355-62. 2009
    ..We attempted to identify parental and infantile behaviour patterns or symptoms that could help distinguish between organic or behavioural causes for these symptoms...
  7. doi request reprint Early-onset Crohn disease is associated with male sex and a polymorphism in the IL-6 promoter
    Keren Sagiv-Friedgut
    Pediatric Gastroenterology Unit, Wolfson Medical Center, Holon Sackler School of Medicine, Tel Aviv University, Israel
    J Pediatr Gastroenterol Nutr 50:22-6. 2010
    ..The aim of our study was to investigate whether differences in IL-6 promoter genotype could explain male sex in earlier disease onset...
  8. ncbi request reprint TNF promoter polymorphisms and modulation of growth retardation and disease severity in pediatric Crohn's disease
    Arie Levine
    Pediatric Gastroenterology and Nutrition Unit, E Wolfson Medical Center, Holon, Israel
    Am J Gastroenterol 100:1598-604. 2005
    ..The aim of our study was to determine whether growth retardation and disease severity in pediatric onset CD are affected by TNF promoter genotype...
  9. ncbi request reprint Evaluation of the interleukin-23 receptor gene coding variant R381Q in pediatric and adult Crohn disease
    Esther Leshinsky-Silver
    Molecular Genetics Laboratory, Holon, Israel
    J Pediatr Gastroenterol Nutr 45:405-8. 2007
    ....
  10. doi request reprint Mathematical weighting of the pediatric Crohn's disease activity index (PCDAI) and comparison with its other short versions
    Dan Turner
    Pediatric Gastroenterology Unit, Shaare Zedek Medical Center, Hebrew University of Jerusalem, Israel
    Inflamm Bowel Dis 18:55-62. 2012
    ....
  11. ncbi request reprint Eradication of Helicobacter pylori can be accurately confirmed 14 days after termination of triple therapy using a high-dose citric acid-based 13C urea breath test
    Haim Shirin
    Department of Gastroenterology, The E Wolfson Medical Center, Holon, Tel Aviv University, Tel Aviv, Israel
    Digestion 71:208-12. 2005
    ..Use of a high-dose citric acid test meal appears to enable accurate detection of H. pylori even during short term therapy with proton pump inhibitors...
  12. doi request reprint Idiopathic pancreatitis preceding the diagnosis of inflammatory bowel disease is more frequent in pediatric patients
    Efrat Broide
    Institute of Gastroenterology, Liver Diseases and Nutrition, Assaf Harofeh Medical Center, Zerifin affiliated with the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    J Pediatr Gastroenterol Nutr 52:714-7. 2011
    ..We aimed to characterize the demographic, clinical, and laboratory data of patients with IBD in whom AP preceded disease onset and compare the presentation of AP between children and adults...
  13. doi request reprint Celiac-associated peptic disease at upper endoscopy: how common is it?
    Arie Levine
    Pediatric Gastroenterology Unit, E Wolfson Medical Center, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
    Scand J Gastroenterol 44:1424-8. 2009
    ..There are only a few case reports linking celiac disease (CD) to PD. We therefore aimed to review our experience of CD presenting with PD...
  14. ncbi request reprint Pediatric Crohn's disease and growth retardation: the role of genotype, phenotype, and disease severity
    Eytan Wine
    Pediatric Gastroenterology and Nutrition Unit, E Wolfson Medical Center, Holon, Israel
    Pediatrics 114:1281-6. 2004
    ..The aim of our study was to determine if growth retardation is affected by genotype independently of disease location or severity...
  15. ncbi request reprint Validation of a novel real time 13C urea breath test for rapid evaluation of Helicobacter pylori in children and adolescents
    Arie Levine
    Pediatric Gastroenterology Unit, Department of Gastroenterology, The E Wolfson Medical Center, Holon, Tel Aviv University, Israel
    J Pediatr 145:112-4. 2004
    ..Results were obtained within 10 minutes in 96% of patients. The test is rapid, user-friendly, and has 100% concordance with conventional diagnostic methods...
  16. ncbi request reprint Application of Maastricht 2-2000 guidelines for the management of Helicobacter pylori among specialists and primary care physicians in israel: are we missing the malignant potential of Helicobacter pylori?
    Haim Shirin
    Department of Gastroenterology, The E Wolfson Medical Center, Holon, Israel
    J Clin Gastroenterol 38:322-5. 2004
    ..The Maastricht 2-2000 guidelines on the current management of Helicobacter pylori infection were recently adopted by the Israeli Gastroenterological Association...
  17. doi request reprint Natural history of food allergy in infants and children in Israel
    Darit Aaronov
    Department of Pediatrics, E Wolfson Medical Center, Holon, Israel
    Ann Allergy Asthma Immunol 101:637-40. 2008
    ..Knowledge about the natural history of food allergy, especially sesame, is scarce...
  18. ncbi request reprint Fat intolerance in developmentally impaired children with severe feeding intolerance
    Arie Levine
    Pediatric Gastroenterology Unit, E Wolfson Medical Center, Holon, Israel
    J Child Neurol 21:167-70. 2006
    ..Dietary fat can provoke upper gastrointestinal symptoms in children with gastric and intestinal dysmotility. Short-term manipulation of dietary fat intake can improve tolerance to feeding...
  19. ncbi request reprint The pattern of sesame sensitivity among infants and children
    Ilan Dalal
    Pediatric Allergy and Clinical Immunology Unit, Hebrew University, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    Pediatr Allergy Immunol 14:312-6. 2003
    ..Although sesame products have become fashionable in westernized countries, early exposure may cause sesame to share eventually the same 'noteriety and fate' as peanut - a major cause of severe food allergic reactions...
  20. ncbi request reprint Consensus and controversy in the management of pediatric Crohn disease: an international survey
    Arie Levine
    Pediatric Gastroenterology Unit, E Wolfson Medical Center, POB 5, Holon 58100, Israel
    J Pediatr Gastroenterol Nutr 36:464-9. 2003
    ..Treatment options for patients with Crohn disease (CD) have expanded, but the use of some of these options in pediatric patients remains controversial. The authors evaluate current trends in treatment and areas of consensus or controversy...
  21. doi request reprint Appraisal of the pediatric Crohn's disease activity index on four prospectively collected datasets: recommended cutoff values and clinimetric properties
    Dan Turner
    Pediatric Gastroenterology Unit, Shaare Zedek Medical Center, The Hebrew University of Jerusalem, Jerusalem, Israel
    Am J Gastroenterol 105:2085-92. 2010
    ..The aim of this study was to provide knowledge on its performance and accuracy of different cutoff scores...
  22. pmc A large homozygous deletion in the SAMHD1 gene causes atypical Aicardi-GoutiƩres syndrome associated with mtDNA deletions
    Esther Leshinsky-Silver
    Molecular Genetics Laboratory, Wolfson Medical Center, Holon, Israel
    Eur J Hum Genet 19:287-92. 2011
    ....
  23. pmc Early satiety is the only patient-reported symptom associated with delayed gastric emptying, as assessed by breath-test
    Yishai Ron
    Department of Gastroenterology and Hepatology, Sourasky Medical Center, Tel Aviv, Israel
    J Neurogastroenterol Motil 17:61-6. 2011
    ..To evaluate associations between delayed gastric emptying (GE) assessed by the octanoic acid breath test and upper gastrointestinal (GI) symptoms...
  24. ncbi request reprint Influence of Helicobacter pylori eradication on gastroesophageal reflux symptoms and epigastric pain in children and adolescents
    Arie Levine
    Pediatric Gastroenterology Unit, Edith Wolfson Medical Center, Holon, Israel
    Pediatrics 113:54-8. 2004
    ..We prospectively evaluated the effect of eradication of H pylori on GER symptoms and epigastric pain and the association among these 3 parameters in a pediatric cohort...
  25. ncbi request reprint Cytokine profile in cerebrospinal fluid of children with echovirus type 4 meningitis
    Ilan Dalal
    Pediatric Infectious Allergy Immunology Unit, E Wolfson Medical Center, Holon, Israel
    Pediatr Neurol 29:312-6. 2003
    ..Interleukin-6 was the most sensitive and specific characteristic in predicting meningitis in this homogeneous group of patients. Furthermore, only interleukin-6 correlated with leukocyte counts in the cerebrospinal fluid...
  26. ncbi request reprint Effect of proton pump inhibitors on the continuous real time (13)C-urea breath test
    Haim Shirin
    Department of Gastroenterology, The E Wolfson Medical Center, Holon, Tel Aviv University, Tel Aviv, Israel
    Am J Gastroenterol 98:46-50. 2003
    ..The aim of this study was to evaluate the accuracy of a new, continuous real time (13)C-urea breath test, BreathID, for the diagnosis of Helicobacter pylori in patients taking proton pump inhibitors (PPIs)...
  27. doi request reprint Coexistence of sleep and feeding disturbances in young children
    Riva Tauman
    Pediatric Sleep Center, Dana Children s Hospital, Tel Aviv Souraski Medical Center, Tel Aviv, Israel
    Pediatrics 127:e615-21. 2011
    ..Despite similarities in nature, etiology, prevalence, and age distribution, the association between these 2 common disorders in young children has not been examined thus far...
  28. doi request reprint Limitations of fecal calprotectin at diagnosis in untreated pediatric Crohn's disease
    Ron Shaoul
    Pediatric Gastroenterology Unit, Rambam Medical Center, Technion, Faculty of Medicine, Haifa, Israel
    Inflamm Bowel Dis 18:1493-7. 2012
    ....
  29. ncbi request reprint Congenital patent ductus venosus: an association with the hyper IgE syndrome
    Keren Sagiv-Friedgut
    Pediatric Gastroenterology Unit, Wolfson Medical Center, Holon, Israel
    J Pediatr 150:210-2. 2007
    ..We describe an association between congenital patent ductus venosus and hyper immunoglobulin E syndrome in a pair of siblings. The possibility that this is a separate entity or a genetically linked association is discussed...
  30. ncbi request reprint Use of quantitative ultrasound to assess osteopenia in children with Crohn disease
    Arie Levine
    Department of Pediatrics and Pediatric Gastroenterology Units, E Wolfson Medical Center, The Sackler School of Medicine, Tel Aviv University, and the Bruce Rappaport School of Medicine, Haifa, Israel
    J Pediatr Gastroenterol Nutr 35:169-72. 2002
    ..Bone density Z scores were evaluated with quantitative ultrasound (QUS) using a novel portable device and were compared with DXA in children with Crohn disease...
  31. ncbi request reprint Encephalopathy associated with Hashimoto thyroiditis: pediatric perspective
    Nathan Watemberg
    Pediatric Neurology Unit, Sackler School of Medicine, Tel Aviv University, Israel
    J Child Neurol 21:1-5. 2006
    ..Moreover, early recognition might also avoid an expensive diagnostic work-up in patients with unexplained encephalopathy (J Child Neurol 2006;21:1-5)...
  32. ncbi request reprint Extrapancreatic autoimmune manifestations in type 1 diabetes patients and their first-degree relatives: a multicenter study
    Aaron Hanukoglu
    Department of Pediatrics, E Wolfson Medical Center, Holon and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    Diabetes Care 26:1235-40. 2003
    ..To investigate the prevalence of autoimmune diseases in young patients (probands) with type 1 diabetes and their first-degree relatives, and to determine the spectrum of extrapancreatic manifestations in these subjects...
  33. doi request reprint Effects of enteral nutrition on Crohn's disease: clues to the impact of diet on disease pathogenesis
    Arie Levine
    Pediatric Gastroenterology Unit, Wolfson Medical Center, Sackler School of Medicine, Tel Aviv University, Holon, Israel
    Inflamm Bowel Dis 19:1322-9. 2013
    ....
  34. doi request reprint Atypical disease phenotypes in pediatric ulcerative colitis: 5-year analyses of the EUROKIDS Registry
    Arie Levine
    Pediatric Gastroenterology and Nutrition Unit, E Wolfson Medical Center, Tel Aviv University, Holon, Israel
    Inflamm Bowel Dis 19:370-7. 2013
    ..Our aim was to identify the prevalence of atypical disease patterns in new-onset pediatric UC using the Paris classification...
  35. doi request reprint Pediatric inflammatory bowel disease: is it different?
    Arie Levine
    Pediatric Gastroenterology and Nutrition Unit, Wolfson Medical Center, Tel Aviv University, Tel Aviv 58100, Israel
    Dig Dis 27:212-4. 2009
    ..Disease behavior, with the exception of growth failure, seems to parallel disease behavior in adults. Patients with growth retardation are a high risk group for complications and should be managed as such...
  36. doi request reprint Comparison of two dosing methods for induction of response and remission with oral budesonide in active pediatric Crohn's disease: a randomized placebo-controlled trial
    Arie Levine
    Pediatric Gastroenterology Unit, Wolfson Medical Center and Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
    Inflamm Bowel Dis 15:1055-61. 2009
    ..Remission rates in pediatric studies to date have been suboptimal (47%-55%), even though patients with colonic involvement were excluded in some studies. In addition, the optimal pediatric dosing regimen has never been evaluated before...
  37. ncbi request reprint Risk factors for perianal Crohn's disease: the role of genotype, phenotype, and ethnicity
    Amir Karban
    Departments of Medicine and Gastroenterology, Rambam Medical Center, Haifa, Israel
    Am J Gastroenterol 102:1702-8. 2007
    ..This study was undertaken to evaluate the role of genotype, clinical, and demographic characteristics with PD...
  38. ncbi request reprint The relation between NOD2/CARD15 mutations and the prevalence and phenotypic heterogeneity of Crohn's disease: lessons from the Israeli Arab Crohn's disease cohort
    Amir Karban
    Department of Gastroenterology, Rambam Medical Center, Haifa
    Dig Dis Sci 50:1692-7. 2005
    ....
  39. ncbi request reprint NOD2/CARD15 mutations and presence of granulomas in pediatric and adult Crohn's disease
    Ron Shaoul
    Bnei Zion Medical Center, Haifa, Israel
    Inflamm Bowel Dis 10:709-14. 2004
    ..We evaluated a possible association between NOD2 mutations and granuloma formation, and compared the prevalence of granulomas in both pediatric and adult cohorts...
  40. ncbi request reprint Polymorphisms in the TNF-alpha promoter and variability in the granulomatous response in patients with Crohn's disease
    Ilan Dalal
    Department of Pediatrics, E Wolfson Medical Center, Holon 58100, Isreal
    Pediatr Res 59:825-8. 2006
    ..In conclusion, we did not find an association between individual polymorphisms in the TNF-alpha promoter and presence of granulomas in CD. The reason for heterogeneity in granuloma formation in patients with CD remains elusive...
  41. ncbi request reprint A polymorphism in the TNF-alpha promoter gene is associated with pediatric onset and colonic location of Crohn's disease
    Arie Levine
    Pediatric Gastroenterology Service, E Wolfson Medical Center, PO Box 5, Holon 58100, Israel
    Am J Gastroenterol 100:407-13. 2005
    ..We hypothesized that polymorphisms that affect TNF-alpha function may influence variability of disease location and AOO of CD...
  42. ncbi request reprint Collagenous gastritis: a rare cause of abdominal pain and iron-deficiency anemia
    Michal Kori
    Department of Pediatric Gastroenterology, Kaplan Medical Center, PO Box 1, Rehovot, Israel
    J Pediatr Gastroenterol Nutr 45:603-6. 2007
  43. doi request reprint Peptic ulcers and erosions are common in Israeli children undergoing upper endoscopy
    Rania Egbaria
    Department of Pediatrics, Bnai Zion Medical Center, Faculty of Medicine, Technion, Haifa, Israel
    Helicobacter 13:62-8. 2008
    ..pylori) and have easy access to pediatric gastroenterologists and endoscopy. Our aim was to describe the prevalence and characteristics of PU&E in this population referred by Pediatric Gastroenterologists for an upper endoscopy...
  44. ncbi request reprint Evaluation of oral budesonide for treatment of mild and moderate exacerbations of Crohn's disease in children
    Arie Levine
    Pediatric Gastroenterology Units of the Edith Wolfson Medical Center, Tel Aviv University Sackler School of Medicine, Israel
    J Pediatr 140:75-80. 2002
    ..We report the results of a retrospective study of budesonide treatment in mild to moderate Crohn's disease in children...
  45. ncbi request reprint A comparison of budesonide and prednisone for the treatment of active pediatric Crohn disease
    Arie Levine
    Department of Pediatrics, B Sheba Medical Center, Tel Hashomer, Israel
    J Pediatr Gastroenterol Nutr 36:248-52. 2003
    ..Therefore, the authors initiated a trial to compare remission and tolerance to budesonide and prednisone in children with mild or moderately active Crohn disease...
  46. ncbi request reprint Nutritional supplementation with polymeric diet enriched with transforming growth factor-beta 2 for children with Crohn's disease
    Corina Hartman
    Institute of Gastroenterology, Nutrition and Liver Diseases, Schneider Children s Medical Center of Israel, Petah Tikva, Israel
    Isr Med Assoc J 10:503-7. 2008
    ..A polymeric diet rich in transforming growth factor-beta 2 used as a single nutrient has been shown to induce remission in 79% of children with Crohn's disease...
  47. ncbi request reprint Growth retardation in pediatric Crohn's disease: pathogenesis and interventions
    Raanan Shamir
    Pediatric Gastroenterology Division of the Meyer Children s Hospital, Haifa
    Inflamm Bowel Dis 13:620-8. 2007
    ..This review summarizes current knowledge as well as gaps in our understanding of the mechanisms involved and the usefulness of the different treatment modalities in promoting growth in CD patients...