Aaron Lerner

Summary

Country: Israel

Publications

  1. ncbi request reprint Aluminum is a potential environmental factor for Crohn's disease induction: extended hypothesis
    Aaron Lerner
    Pediatric Gastroenterology and Nutrition Unit, Carmel Medical Center, Pappaport School of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    Ann N Y Acad Sci 1107:329-45. 2007
  2. ncbi request reprint [Future therapeutics in celiac disease]
    Aaron Lerner
    Pediatric Gastroenterology and Nutrition Unit, Carmel Medical Center, B Rapapport School of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    Harefuah 151:358-61, 377. 2012
  3. pmc The thrombophilic network of autoantibodies in celiac disease
    Aaron Lerner
    Pediatric Gastroenterology and Nutrition Unit, Carmel Medical Center, B, Rappaport School of Medicine, Technion Israel Institute of Technology, Michal St, No 7, Haifa, 34362, Israel
    BMC Med 11:89. 2013
  4. doi request reprint The clinical significance of 25OH-Vitamin D status in celiac disease
    Aaron Lerner
    Pediatric Gastroenterology and Nutrition Unit, Carmel Medical Center, B Rappaport School of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    Clin Rev Allergy Immunol 42:322-30. 2012
  5. doi request reprint Aluminum as an adjuvant in Crohn's disease induction
    A Lerner
    Pediatric Gastroenterology and Nutrition Unit, Carmel Medical Center, Haifa, Israel
    Lupus 21:231-8. 2012
  6. doi request reprint New therapeutic strategies for celiac disease
    Aaron Lerner
    Pediatric Gastroenterology and Nutrition Unit, Carmel Medical Center, B Rappaport School of Medicine, 7, Michal St, Technion Israel Institute of Technology, Haifa, 34362, Israel
    Autoimmun Rev 9:144-7. 2010
  7. doi request reprint The last two millennias echo-catastrophes are the driving forces for the potential genetic advantage mechanisms in celiac disease
    Lerner Aaron
    Pediatric Gastroenterology and Nutrition Unit, Carmel Medical Center, B Rappaport School of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    Med Hypotheses 77:773-6. 2011
  8. ncbi request reprint The use of a single serological marker underestimates the prevalence of celiac disease in Israel: a study of blood donors
    Raanan Shamir
    Department of Pediatrics, Rambam Medical Center, Haifa, Israel
    Am J Gastroenterol 97:2589-94. 2002
  9. ncbi request reprint Parenteral arginine impairs intestinal adaptation following massive small bowel resection in a rat model
    Igor Sukhotnik
    Department of Pediatric Surgery, Rappaport Faculty of Medicine, Bnai Zion Medical Center, Technion Israel Institute of Technology, 47 Golomb St, P O Box 4940, Haifa 31048, Israel
    Pediatr Surg Int 21:460-5. 2005
  10. ncbi request reprint Associated autoantibodies in celiac disease
    Ron Shaoul
    Department of Pediatrics, Bnai Zion Medical Center, Haifa, Israel
    Autoimmun Rev 6:559-65. 2007

Collaborators

Detail Information

Publications26

  1. ncbi request reprint Aluminum is a potential environmental factor for Crohn's disease induction: extended hypothesis
    Aaron Lerner
    Pediatric Gastroenterology and Nutrition Unit, Carmel Medical Center, Pappaport School of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    Ann N Y Acad Sci 1107:329-45. 2007
    ..The Al-bacterial interaction, the microparticles homing the intestine together with the extensive immune activity, put Al as a potential environmental candidate for CD induction and maintenance...
  2. ncbi request reprint [Future therapeutics in celiac disease]
    Aaron Lerner
    Pediatric Gastroenterology and Nutrition Unit, Carmel Medical Center, B Rapapport School of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    Harefuah 151:358-61, 377. 2012
    ..Most of the above strategies showed promising results ex-vivo. The future will highlight the in-vivo winner...
  3. pmc The thrombophilic network of autoantibodies in celiac disease
    Aaron Lerner
    Pediatric Gastroenterology and Nutrition Unit, Carmel Medical Center, B, Rappaport School of Medicine, Technion Israel Institute of Technology, Michal St, No 7, Haifa, 34362, Israel
    BMC Med 11:89. 2013
    ..However, the well known thrombogenic factors, antiphosphatidylserine/prothrombin and antiprothrombin have never been explored in celiac disease...
  4. doi request reprint The clinical significance of 25OH-Vitamin D status in celiac disease
    Aaron Lerner
    Pediatric Gastroenterology and Nutrition Unit, Carmel Medical Center, B Rappaport School of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    Clin Rev Allergy Immunol 42:322-30. 2012
    ..019). In conclusion, Vitamin D sera levels negatively correlate with age. Thus, mainly adult CD population should be assessed for vitamin D levels and supplemented accordingly...
  5. doi request reprint Aluminum as an adjuvant in Crohn's disease induction
    A Lerner
    Pediatric Gastroenterology and Nutrition Unit, Carmel Medical Center, Haifa, Israel
    Lupus 21:231-8. 2012
    ..If a cause and effect relationship can be established, the consequences will greatly impact public health and CD prevention and management...
  6. doi request reprint New therapeutic strategies for celiac disease
    Aaron Lerner
    Pediatric Gastroenterology and Nutrition Unit, Carmel Medical Center, B Rappaport School of Medicine, 7, Michal St, Technion Israel Institute of Technology, Haifa, 34362, Israel
    Autoimmun Rev 9:144-7. 2010
    ..Safety, effectiveness, cost and affordability are prime issues to consider. Some modalities have shown promising results in vitro. Future will show who will win the race...
  7. doi request reprint The last two millennias echo-catastrophes are the driving forces for the potential genetic advantage mechanisms in celiac disease
    Lerner Aaron
    Pediatric Gastroenterology and Nutrition Unit, Carmel Medical Center, B Rappaport School of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    Med Hypotheses 77:773-6. 2011
    ..The present hypothesis can shed light on additional selective genetic adaptations, echo catastrophe-driven that are at the basis of autoimmune disease-affected population survival and current expansion...
  8. ncbi request reprint The use of a single serological marker underestimates the prevalence of celiac disease in Israel: a study of blood donors
    Raanan Shamir
    Department of Pediatrics, Rambam Medical Center, Haifa, Israel
    Am J Gastroenterol 97:2589-94. 2002
    ....
  9. ncbi request reprint Parenteral arginine impairs intestinal adaptation following massive small bowel resection in a rat model
    Igor Sukhotnik
    Department of Pediatric Surgery, Rappaport Faculty of Medicine, Bnai Zion Medical Center, Technion Israel Institute of Technology, 47 Golomb St, P O Box 4940, Haifa 31048, Israel
    Pediatr Surg Int 21:460-5. 2005
    ..In conclusion, in a rat model of SBS, parenteral arginine inhibits structural intestinal adaptation. Decreased cell proliferation and increased apoptosis are the main mechanisms responsible for decreased cell mass...
  10. ncbi request reprint Associated autoantibodies in celiac disease
    Ron Shaoul
    Department of Pediatrics, Bnai Zion Medical Center, Haifa, Israel
    Autoimmun Rev 6:559-65. 2007
    ..The CD associated autoantibodies enigma, being an epiphenomenon or pathogenic, remains unresolved and presents a challenging area for future research...
  11. doi request reprint Severe lysosomal storage disease of liver in del(1)(p36): a new presentation
    Motti Haimi
    Children s Health Center, Clalit Health Services, ArmonTower, Haifa, Israel
    Eur J Med Genet 54:209-13. 2011
    ..The accumulation in the liver with abnormal ultrastructure may be an additional feature of this form of syndromal obesity. 1p36 deletion syndrome should be considered in patients with obesity, hyperphagia and liver fat accumulation...
  12. doi request reprint What's in a name?-"Lipolysosome": ultrastructural features of a lipid-containing organelle
    Theodore C Iancu
    Technion Israel Institute of Technology, Haifa, Israel
    Ultrastruct Pathol 37:293-303. 2013
    ..These new findings demonstrate the presence of lipolysosomes in a variety of fatty livers, in conditions hitherto unknown, in relation to the severity of steatosis, fibrogenic process, autophagy, lipolysis, and lipofuscin formation...
  13. ncbi request reprint Bone quantitative ultrasound and bone mineral density in children with celiac disease
    Corina Hartman
    Division of Pediatric Gastroenterology and Nutrition, Meyer Children s Hospital, Rambam Medical Center, Haifa, Israel
    J Pediatr Gastroenterol Nutr 39:504-10. 2004
    ..Bone quantitative ultrasound (QUS) has recently emerged as a new modality for bone status assessment. We evaluated bone status in children with CD using dual-energy x-ray absorptiometry and quantitative ultrasound...
  14. ncbi request reprint ELISA of anti-endomysial antibodies in the diagnosis of celiac disease: comparison with immunofluorescence assay of anti-endomysial antibodies and tissue transglutaminase antibodies
    Raanan Shamir
    Division of Pediatric Gastroenterology and Nutrition, Department of Pediatrics, Rambam Medical Center, Haifa, Israel
    Isr Med Assoc J 4:594-6. 2002
    ..Recently, tissue transglutaminase has been identified as the target autoantigen of antibodies against endomysium, and TTG antibodies are comparable to EMA-IMF in the diagnosis of CD...
  15. doi request reprint Bronchial reactivity and fractional exhaled NO in Crohn's disease in the era of immunomodulating treatment
    Galit Livnat
    Pediatric Pulmonary Unit, Meyer Children s Hospital, Rambam Health Care Campus, Haifa, Israel
    Acta Paediatr 101:e399-404. 2012
    ..Our aim was to determine bronchial hyper-responsiveness (BHR) and fractional exhaled NO (FeNO) in a cohort followed and treated for Crohn's disease (CD) in a Pediatric Gastroenterology Unit...
  16. ncbi request reprint Paternal isodisomy of chromosome 7 with cystic fibrosis and overgrowth
    Fuad Fares
    Department of Molecular Genetics, Technion Israel Institute of Technology, Haifa, Israel
    Am J Med Genet A 140:1785-8. 2006
    ..The discrepancy between the phenotype of this boy and the other two patients raises the question of imprinted genes or homozygotization of a disease-causing gene in paternal UPD7...
  17. ncbi request reprint Range of neurologic disorders in patients with celiac disease
    Nathanel Zelnik
    Department of Pediatrics, Carmel Medical Center, The Bruce Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    Pediatrics 113:1672-6. 2004
    ..The aim of the present study is to look for a broader spectrum of neurologic disorders in CD patients, most of them children or young adults...
  18. ncbi request reprint Pediatric Crohn's disease and growth retardation: the role of genotype, phenotype, and disease severity
    Eytan Wine
    Pediatric Gastroenterology and Nutrition Unit, E Wolfson Medical Center, Holon, Israel
    Pediatrics 114:1281-6. 2004
    ..The aim of our study was to determine if growth retardation is affected by genotype independently of disease location or severity...
  19. ncbi request reprint Identification of two mutations for ataxia telangiectasia among the Druze community
    Fuad Fares
    Department of Biochemistry and Molecular Genetics, Carmel Medical Center, Haifa, Israel
    Prenat Diagn 24:358-62. 2004
    ..The ability to identify AT carriers routinely provides a unique opportunity for prenatal diagnosis, genetic counseling as well as marriage guidance in the Druze community...
  20. doi request reprint A new algorithm for the diagnosis of celiac disease
    Orit Rozenberg
    Central Laboratory of Haifa and Western Galilee, Clalit Health Services and Pediatric Gastroenterology, Haifa, Israel
    Cell Mol Immunol 8:146-9. 2011
    ..The newly proposed three-assay algorithm for celiac detection is very reliable in both children and adults. Due to the high performance of this assay, the further need for confirmatory intestinal biopsies will be reassessed...
  21. ncbi request reprint Effects of enteral arginine supplementation on the structural intestinal adaptation in a rat model of short bowel syndrome
    Igor Sukhotnik
    Rappaport Faculty of Medicine, Technion, Department of Surgery, Carmel Medical Center, Haifa, Israel
    Dig Dis Sci 48:1346-51. 2003
    ..We conclude that in a rat model of SBS enteral L-arginine inhibits structural intestinal adaptation. Possible mechanism for this effect may be decreased cell proliferation and increased cell apoptosis...
  22. doi request reprint Remifentanil versus fentanyl for esophagogastroduodenoscopy in children
    Irina Hirsh
    Department of Anesthesiology, Critical Care and Pain Medicine, Lady Davis Carmel Medical Center, Haifa, Israel
    J Pediatr Gastroenterol Nutr 51:618-21. 2010
    ..We compared sedation by propofol combined with either fentanyl or remifentanil in pediatric outpatients undergoing diagnostic esophagogastroduodenoscopy...
  23. ncbi request reprint Inherited mannose-binding lectin deficiency as evidenced by genetic and immunologic analyses: association with severe recurrent infections
    Patricia Martin
    All Childrens Hospital University of South Florida College of Medicine, Department of Pediatrics, Division of Allergy and Immunology, St Petersburg, Florida 33701, USA
    Ann Allergy Asthma Immunol 91:386-92. 2003
    ..Concomitant MBL deficiency in patients with chronic immunologic disease has been associated with increased susceptibility to complicating infections that may hasten disease progression...
  24. ncbi request reprint Antibodies against laminaribioside and chitobioside are novel serologic markers in Crohn's disease
    Iris Dotan
    IBD Service, Department of Gastroenterology and Liver Diseases, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
    Gastroenterology 131:366-78. 2006
    ..We profiled sugar-binding antibodies to identify novel antiglycan antibodies that may be associated with inflammatory bowel disease...
  25. doi request reprint Cystic fibrosis transmembrane conductance regulator ion channel function testing in recurrent acute pancreatitis
    Idit Segal
    CF Center, Hadassah University Hospital, Jerusalem, Israel
    J Clin Gastroenterol 42:810-4. 2008
    ..To understand the relationship between acute recurrent pancreatitis and cystic fibrosis transmembrane conductance regulator (CFTR) dysfunction...
  26. ncbi request reprint K-ras mutations in sporadic colorectal tumors in Israel: unusual high frequency of codon 13 mutations and evidence for nonhomogeneous representation of mutation subtypes
    Dmitry Kislitsin
    Department of Biology, Technion Israel Institute of Technology, Haifa
    Dig Dis Sci 47:1073-9. 2002
    ..The heterogeneous distribution found may be due to a variable genetic background and different environmental factors involved in the initiation and propagation of sporadic colorectal cancer...