Ehud Klein

Summary

Country: Israel

Publications

  1. ncbi request reprint Sleep complaints are not corroborated by objective sleep measures in post-traumatic stress disorder: a 1-year prospective study in survivors of motor vehicle crashes
    Ehud Klein
    Department of Psychiatry of the Rambam Medical Center and the B Rappaport Faculty of Medicine, Technion I I T, Haifa, Israel
    J Sleep Res 12:35-41. 2003
  2. ncbi request reprint No evidence of sleep disturbance in post-traumatic stress disorder: a polysomnographic study in injured victims of traffic accidents
    Ehud Klein
    Department of Psychiatry, Rambam Medical Center, and Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    Isr J Psychiatry Relat Sci 39:3-10. 2002
  3. ncbi request reprint The role of extended-release benzodiazepines in the treatment of anxiety: a risk-benefit evaluation with a focus on extended-release alprazolam
    Ehud Klein
    Department of Psychiatry, Rambam Medical Center, Haifa, Israel
    J Clin Psychiatry 63:27-33. 2002
  4. ncbi request reprint The relation between memory of the traumatic event and PTSD: evidence from studies of traumatic brain injury
    Ehud Klein
    Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Department of Psychiatry, Rambam Medical Center, Haifa, Israel
    Can J Psychiatry 48:28-33. 2003
  5. ncbi request reprint Does memory of a traumatic event increase the risk for posttraumatic stress disorder in patients with traumatic brain injury? A prospective study
    Sharon Gil
    Department of Psychiatry, Rambam Medical Center, Rappaport Faculty of Medicine, Technion Israel Institute of Technology, P O Box 9602, Haifa 31096, Israel
    Am J Psychiatry 162:963-9. 2005
  6. doi request reprint Physical stress differs from psychosocial stress in the pattern and time-course of behavioral responses, serum corticosterone and expression of plasticity-related genes in the rat
    Alexandra Kavushansky
    Laboratory of Psychobiology, Department of Psychiatry, Rambam Medical Center, B Rappaport Faculty of Medicine, Bat Galim, Technion, Haifa, 31096, Israel
    Stress 12:412-25. 2009
  7. doi request reprint Dexamethasone enhances the norepinephrine-induced ERK/MAPK intracellular pathway possibly via dysregulation of the alpha2-adrenergic receptor: implications for antidepressant drug mechanism of action
    Shiri P Yaniv
    Department of Psychiatry, Rambam Medical Center and B Rappaport Faculty of Medicine, Technion, Haifa, Israel
    Eur J Cell Biol 89:712-22. 2010
  8. doi request reprint DNA methylation in vulnerability to post-traumatic stress in rats: evidence for the role of the post-synaptic density protein Dlgap2
    Yael Chertkow-Deutsher
    Research Laboratory of Psychobiology, Department of Psychiatry, Rambam Medical Center, Bruce Rappaport Faculty of Medicine, Technion IIT, Haifa, Israel
    Int J Neuropsychopharmacol 13:347-59. 2010
  9. doi request reprint Acute stress reactions among medical and non-medical personnel in a general hospital under missile attacks
    Danny Koren
    Psychology Department, University of Haifa, Haifa, Israel
    Depress Anxiety 26:123-8. 2009
  10. doi request reprint Mitochondrial complex I as a novel target for intraneuronal DA: modulation of respiration in intact cells
    Hanit Brenner-Lavie
    Research Laboratory of Psychobiology, Department of Psychiatry, Rambam Medical Center, Bruce Rappaport Faculty of Medicine, Technion IIT, Haifa, Israel
    Biochem Pharmacol 78:85-95. 2009

Collaborators

Detail Information

Publications40

  1. ncbi request reprint Sleep complaints are not corroborated by objective sleep measures in post-traumatic stress disorder: a 1-year prospective study in survivors of motor vehicle crashes
    Ehud Klein
    Department of Psychiatry of the Rambam Medical Center and the B Rappaport Faculty of Medicine, Technion I I T, Haifa, Israel
    J Sleep Res 12:35-41. 2003
    ....
  2. ncbi request reprint No evidence of sleep disturbance in post-traumatic stress disorder: a polysomnographic study in injured victims of traffic accidents
    Ehud Klein
    Department of Psychiatry, Rambam Medical Center, and Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    Isr J Psychiatry Relat Sci 39:3-10. 2002
    ..Thus, little is known about the development of sleep disturbances in recently traumatized subjects...
  3. ncbi request reprint The role of extended-release benzodiazepines in the treatment of anxiety: a risk-benefit evaluation with a focus on extended-release alprazolam
    Ehud Klein
    Department of Psychiatry, Rambam Medical Center, Haifa, Israel
    J Clin Psychiatry 63:27-33. 2002
    ....
  4. ncbi request reprint The relation between memory of the traumatic event and PTSD: evidence from studies of traumatic brain injury
    Ehud Klein
    Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Department of Psychiatry, Rambam Medical Center, Haifa, Israel
    Can J Psychiatry 48:28-33. 2003
    ..Traumatic brain injury (TBI) is used as a naturally occurring model for traumatic exposure that is often associated with memory impairment...
  5. ncbi request reprint Does memory of a traumatic event increase the risk for posttraumatic stress disorder in patients with traumatic brain injury? A prospective study
    Sharon Gil
    Department of Psychiatry, Rambam Medical Center, Rappaport Faculty of Medicine, Technion Israel Institute of Technology, P O Box 9602, Haifa 31096, Israel
    Am J Psychiatry 162:963-9. 2005
    ....
  6. doi request reprint Physical stress differs from psychosocial stress in the pattern and time-course of behavioral responses, serum corticosterone and expression of plasticity-related genes in the rat
    Alexandra Kavushansky
    Laboratory of Psychobiology, Department of Psychiatry, Rambam Medical Center, B Rappaport Faculty of Medicine, Bat Galim, Technion, Haifa, 31096, Israel
    Stress 12:412-25. 2009
    ..These results indicate stressor-specific time-dependent changes in different neuronal pathways, and suggest consideration of a cause-specific approach to the treatment of stress-related disorders...
  7. doi request reprint Dexamethasone enhances the norepinephrine-induced ERK/MAPK intracellular pathway possibly via dysregulation of the alpha2-adrenergic receptor: implications for antidepressant drug mechanism of action
    Shiri P Yaniv
    Department of Psychiatry, Rambam Medical Center and B Rappaport Faculty of Medicine, Technion, Haifa, Israel
    Eur J Cell Biol 89:712-22. 2010
    ..These results show a novel complex interaction by which GCs augment NE-induced intracellular signaling that may be relevant to antidepressant mode of action...
  8. doi request reprint DNA methylation in vulnerability to post-traumatic stress in rats: evidence for the role of the post-synaptic density protein Dlgap2
    Yael Chertkow-Deutsher
    Research Laboratory of Psychobiology, Department of Psychiatry, Rambam Medical Center, Bruce Rappaport Faculty of Medicine, Technion IIT, Haifa, Israel
    Int J Neuropsychopharmacol 13:347-59. 2010
    ..These results suggest that alterations in global methylation pattern are involved in behavioural adaptation to environmental stress and pinpoint Dlgap2 as a possible target in PTSD...
  9. doi request reprint Acute stress reactions among medical and non-medical personnel in a general hospital under missile attacks
    Danny Koren
    Psychology Department, University of Haifa, Haifa, Israel
    Depress Anxiety 26:123-8. 2009
    ....
  10. doi request reprint Mitochondrial complex I as a novel target for intraneuronal DA: modulation of respiration in intact cells
    Hanit Brenner-Lavie
    Research Laboratory of Psychobiology, Department of Psychiatry, Rambam Medical Center, Bruce Rappaport Faculty of Medicine, Technion IIT, Haifa, Israel
    Biochem Pharmacol 78:85-95. 2009
    ..Such a mechanism may be of relevance to DA-related non-degenerative pathologies such as schizophrenia...
  11. ncbi request reprint Effect of electroconvulsive therapy on cortical excitability in patients with major depression: a transcranial magnetic stimulation study
    Andrei V Chistyakov
    Laboratory of Clinical Neurosciences, Department of Neurosurgery, Rambam Maimonides Medical Center, B Rappaport Faculty of Medicine, The Technion, Israel Institute of Technology, Haifa, Israel
    Clin Neurophysiol 116:386-92. 2005
    ..The aim of this study was to investigate changes in cortical excitability following ECT in patients with major depression (MD) and to compare therapeutic efficacy of ECT combined with rTMS to that of ECT alone...
  12. doi request reprint Risk factors for the development of posttraumatic stress disorder following combat trauma: a semiprospective study
    Joseph Zohar
    Department of Psychiatry, Chaim Sheba Medical Center, Tel Hashomer 52621, Israel
    J Clin Psychiatry 70:1629-35. 2009
    ..This study aimed to explore risk factors for developing PTSD in order to improve the psychiatric screening process of new recruits...
  13. ncbi request reprint Validation of a screening instrument for posttraumatic stress disorder in a community sample of Bedouin men serving in the Israeli Defense Forces
    Yael Caspi
    Department of Psychiatry, Rambam Medical Center, Haifa, Israel
    J Trauma Stress 20:517-27. 2007
    ..5, yielding equal sensitivity and specificity rates of 89%. Likelihood ratios indicated that men with positive screens who did not meet criteria for PTSD were likely to report significant emotional distress and functional impairment...
  14. doi request reprint Safety, tolerability and preliminary evidence for antidepressant efficacy of theta-burst transcranial magnetic stimulation in patients with major depression
    Andrei V Chistyakov
    Department of Neurosurgery, Rambam Medical Center, B Rappaport Faculty of Medicine, The Technion, Israel Institute of Technology, Haifa, Israel
    Int J Neuropsychopharmacol 13:387-93. 2010
    ..Increase of stimulation parameters is not associated with more side-effects and adds to its therapeutic effect...
  15. ncbi request reprint Dopamine modulates mitochondrial function in viable SH-SY5Y cells possibly via its interaction with complex I: relevance to dopamine pathology in schizophrenia
    Hanit Brenner-Lavie
    Research Lab of Psychobiology, Department of Psychiatry Rambam Medical Center, Bruce Rappaport Faculty of Medicine, Technion, Haifa, Israel
    Biochim Biophys Acta 1777:173-85. 2008
    ..These results suggest a non-lethal interaction between DA and mitochondria possibly via complex I, which can better explain DA-related pathological processes observed in non-degenerative disorders, such as schizophrenia...
  16. doi request reprint Trauma exposure and posttraumatic reactions in a community sample of Bedouin members of the Israel Defense Forces
    Yael Caspi
    Department of Psychiatry, Rambam Medical Center, Haifa, Israel
    Depress Anxiety 25:700-7. 2008
    ..This study explored traumatic exposure and impact on mental and physical health, functioning, and medical services utilization in a previously unstudied ethnic minority group of Bedouins enlisted in the Israeli Defense Forces...
  17. doi request reprint Norepinephrine-glucocorticoids interaction does not annul the opposite effects of the individual treatments on cellular plasticity in neuroblastoma cells
    Shiri P Yaniv
    Laboratory of Psychobiology, Department of Psychiatry, Rambam Medical Center and B Rappaport Faculty of Medicine, Technion, Haifa, Israel
    Eur J Pharmacol 596:14-24. 2008
    ..These results suggest that in order for cells to combat the deleterious effects of glucocorticoids, a hyperactivation of pCREB may be necessary to restore differentiation and plasticity...
  18. ncbi request reprint Sleep complaints as early predictors of posttraumatic stress disorder: a 1-year prospective study of injured survivors of motor vehicle accidents
    Danny Koren
    Department of Psychiatry, Rambam Medical Center, Technion Israel Institute of Technology, Haifa
    Am J Psychiatry 159:855-7. 2002
    ..The causal relationship between sleep complaints and PTSD is unclear...
  19. ncbi request reprint Long-term effects of early parental loss due to divorce on the HPA axis
    Miki Bloch
    Psychiatric Service, Tel Aviv Souraski Medical Center, 6 Weizmann Str, Tel Aviv, 64239, Israel
    Horm Behav 51:516-23. 2007
    ..It is likely that divorce has significant and sustained effects on children's HPA axis only in the context of a traumatic separation...
  20. ncbi request reprint Risk factors associated with the development of postpartum mood disorders
    Miki Bloch
    Psychiatric Service, Tel Aviv Souraski Medical Center, Tel Aviv, Israel
    J Affect Disord 88:9-18. 2005
    ..This study attempts to determine whether such mood phenomena are risk factors for postpartum mood disorders...
  21. ncbi request reprint Risk factors for early postpartum depressive symptoms
    Miki Bloch
    Psychiatric Outpatient Department, Psychiatric Service, Tel Aviv Souraski Medical Center, Tel Aviv, Israel, 64239
    Gen Hosp Psychiatry 28:3-8. 2006
    ..We examined the association between the reported history of psychiatric symptoms of possible hormonal etiology and very early postpartum depressive symptoms...
  22. doi request reprint β-endorphin degradation and the individual reactivity to traumatic stress
    Alexandra Kavushansky
    Department of Internal Medicine, Rambam Medical Center, Laboratory of Psychobiology, B Rappaport Faculty of Medicine and B Rappaport Research Institute, Technion, Haifa, Israel
    Eur Neuropsychopharmacol 23:1779-88. 2013
    ..Modulation of opioid degradation may thus present a potential novel target for interference with extreme anxiety. ..
  23. ncbi request reprint Cerebral glucose utilization and platelet mitochondrial complex I activity in schizophrenia: A FDG-PET study
    Dorit Ben-Shachar
    Laboratory of Psychobiology, Department of Psychiatry, Rambam Medical Center and B Rappaport Faculty of Medicine Technion IIT, Haifa, Israel
    Prog Neuropsychopharmacol Biol Psychiatry 31:807-13. 2007
    ..These results suggest that the correlation between peripheral complex I activity and rCGM in regions implicated in schizophrenia, could be a pathological factor that is differentially expressed in subgroups of schizophrenic patients...
  24. ncbi request reprint Major depression as a disorder of serotonin resistance: inference from diabetes mellitus type II
    Bella Smolin
    Department of Internal Medicine Rambam Medical Center, B Rappaport Faculty of Medicine, Technion, Haifa, Israel
    Int J Neuropsychopharmacol 10:839-50. 2007
    ....
  25. doi request reprint Bedouin wives on the home front: living with men serving in the Israel Defense Forces
    Yael Caspi
    Department of Psychiatry, Rambam Medical Center, Haifa, Israel
    J Trauma Stress 23:682-90. 2010
    ....
  26. ncbi request reprint Injury increases the risk for PTSD: an examination of potential neurobiological and psychological mediators
    Danny Koren
    Rambam Medical Center, Department of Psychology, University of Haifa, Haifa 31905, Israel
    CNS Spectr 11:616-24. 2006
    ..These pathways are: additive, unique, and recovery impeding. Finally, we highlight unresolved issues pertaining to each one of these pathways and propose directions for future research to address them...
  27. ncbi request reprint Mitochondrial complex I subunits expression is altered in schizophrenia: a postmortem study
    Rachel Karry
    Laboratory of Psychobiology, Department of Psychiatry, Rambam Medical Center, Rappaport Faculty of Medicine, Technion, Haifa, Israel
    Biol Psychiatry 55:676-84. 2004
    ....
  28. doi request reprint Early postnatal interference with the expression of multiple Sp1 regulated genes leads to disparate behavioral response to sub-chronic and chronic stress in rats
    Eyal Asor
    Laboratory of Psychobiology, Department of Psychiatry, Rambam Medical Center and B Rappaport Faculty of Medicine, Technion IIT, Haifa 31096, Israel
    Psychoneuroendocrinology 38:2173-83. 2013
    ..We suggest that an alternative approach is interference with the expression of multiple genes followed by exposure to environmental insults...
  29. ncbi request reprint Alterations in cell adhesion molecule L1 and functionally related genes in major depression: a postmortem study
    Daphna Laifenfeld
    Laboratory of Psychobiology, The Department of Psychiatry, Rambam Medical Center, and B Rappaport Faculty of Medicine, Technion IIT, Haifa, Israel
    Biol Psychiatry 57:716-25. 2005
    ..Presently we hypothesized that CAM-L1, CREB, and laminin may be altered in post mortem brains of depressed subjects...
  30. ncbi request reprint The pro-apoptotic ARTS/Sept4 protein is significantly reduced in post-mortem brains from schizophrenic patients
    Yossi Gottfried
    Apoptosis and Cancer Research Laboratory, Pathology Department, Rambam Medical Center and Faculty of Medicine, Technion, Haifa, Israel
    Schizophr Res 96:257-66. 2007
    ..We propose that ARTS may play an important role in the pathogenesis of schizophrenia and could be used as a marker for this disease...
  31. ncbi request reprint Hypercoagulation in chronic post-traumatic stress disorder
    Odile Robicsek
    Department of Psychiatry, Rambam Health Care Campus affiliated to Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    Isr Med Assoc J 13:548-52. 2011
    ....
  32. doi request reprint Entacapone augmentation of antipsychotic treatment in schizophrenic patients with negative symptoms; a double-blind placebo-controlled study
    Hanoch Kaphzan
    Sagol Department of Neurobiology, University of Haifa, Haifa, Israel
    Int J Neuropsychopharmacol 17:337-40. 2014
    ..However, entacapone did not demonstrate a beneficial effect compared to placebo. Therefore, this study does not support a therapeutic role for entacapone in residual schizophrenia. ..
  33. ncbi request reprint In the Aftermath of trauma: A Community study of Bedouin IdF servicemen and their Families
    Yael Caspi
    Department of Psychiatry, Rambam Medical Health Center, Haifa, Israel
    Isr J Psychiatry Relat Sci 49:167-77. 2012
    ....
  34. ncbi request reprint Antidepressant effects of different schedules of repetitive transcranial magnetic stimulation vs. clomipramine in patients with major depression: relationship to changes in cortical excitability
    Andrei V Chistyakov
    Laboratory of Clinical Neurosciences, Department of Neurosurgery, Rambam Medical Center, B Rappaport Faculty of Medicine, The Technion, Israel Institute of Technology, Haifa, Israel
    Int J Neuropsychopharmacol 8:223-33. 2005
    ..Our results suggest that 3 Hz left rTMS has a higher therapeutic efficacy and tolerability in patients with MD. The enhancement of cortical excitability may be related to the antidepressant action of rTMS...
  35. ncbi request reprint Norepinephrine alters the expression of genes involved in neuronal sprouting and differentiation: relevance for major depression and antidepressant mechanisms
    Daphna Laifenfeld
    Laboratory of Psychobiology, The Department of Psychiatry, Rambam Medical Center and B Rappaport Faculty of Medicine, Technion IIT, Haifa, Israel
    J Neurochem 83:1054-64. 2002
    ..Taken together, the results support a role for NE in processes of synaptic connectivity, and may point to a role for this neurotransmitter in mediating the suggested neuronal plasticity in depression and in antidepressant treatment...
  36. ncbi request reprint Increased emotional distress in daughters of breast cancer patients is associated with decreased natural cytotoxic activity, elevated levels of stress hormones and decreased secretion of Th1 cytokines
    Miri Cohen
    Department of Immunology, Rambam Medical Center and B Rappaport Faculty of Medicine Technion, Haifa, Israel
    Int J Cancer 100:347-54. 2002
    ..This may contribute to the increased risk of DBCP to develop breast cancer. An interventional trial to enhance coping and reduce stress levels may help to decrease the risk for breast cancer onset in DBCP...
  37. ncbi request reprint The neuropsychological basis of insight in first-episode schizophrenia: a pilot metacognitive study
    Danny Koren
    Psychology Department, University of Haifa, Haifa 31905, Israel
    Schizophr Res 70:195-202. 2004
    ..These preliminary results suggest that metacognition is an important mediator between basic cognitive deficits and poor insight, and might be even more relevant to poor insight than cognitive deficits per se...
  38. ncbi request reprint Predominance of younger age, advanced stage, poorly-differentiated and mucinous histology in Israeli Arab patients with colorectal cancer
    Baruch Shpitz
    Department of Surgery, Meir General Hospital, Sapir Medical Center, Kfar Sava, Israel
    Anticancer Res 26:533-7. 2006
    ..Colorectal cancer (CRC) incidence in the Israeli population is higher in the Jewish population than among Arabs...
  39. ncbi request reprint Rapid tryptophan depletion as a treatment for acute mania: a double-blind, pilot-controlled study
    Julia Applebaum
    Ministry of Health Mental Health Center, Faculty of Health Sciences, Ben Gurion University of the Negev, Beersheva, Israel
    Bipolar Disord 9:884-7. 2007
    ..Rapid tryptophan depletion (RTD) has been shown to induce transient depressive symptoms in patients with remitted major depression. The effect of RTD in acutely manic patients has not been studied...
  40. ncbi request reprint Memory of the traumatic event as a risk factor for the development of PTSD: lessons from the study of traumatic brain injury
    Sharon Gil
    Faculty of Social Welfare and Health Studies, School of Social Work, University of Haifa, Haifa 31905, Israel
    CNS Spectr 11:603-7. 2006
    ..This article presents a critical review of these research efforts and discusses their theoretical and clinical implications...