Sandra E Kleiman

Summary

Country: Israel

Publications

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    Kleiman S, Lagziel A, Yogev L, Botchan A, Paz G, Yavetz H. Expression of CDY1 may identify complete spermatogenesis. Fertil Steril. 2001;75:166-73 pubmed
    ..Our preliminary results suggest that CDY1-minor expression might increase the prospect for complete spermatogenesis, while RBM and DAZ expression can only be indicative of the presence of germinal cells. ..
  2. Kleiman S, Yogev L, Lehavi O, Hauser R, Botchan A, Paz G, et al. The likelihood of finding mature sperm cells in men with AZFb or AZFb-c deletions: six new cases and a review of the literature (1994-2010). Fertil Steril. 2011;95:2005-12, 2012.e1-4 pubmed publisher
    ..Referring men with complete AZFb/b-c microdeletions to testicular sperm extraction/ICSI programs should be revaluated. ..
  3. Kleiman S, Yogev L, Lehavi O, Yavetz H, Hauser R. Distinctive pattern of expression of spermatogenic molecular markers in testes of azoospermic men with non-mosaic Klinefelter syndrome. J Assist Reprod Genet. 2016;33:807-14 pubmed publisher
    ..It is suggested that this difference might be due to the specific highly abnormal histological morphometric parameters in KS specimens. ..
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    Kleiman S, Yogev L, Gal Yam E, Hauser R, Gamzu R, Botchan A, et al. Reduced human germ cell-less (HGCL) expression in azoospermic men with severe germinal cell impairment. J Androl. 2003;24:670-5 pubmed
    ..Our results suggest that HGCL is not essential for the chromosomal events of meiosis but might be involved in later aspects of spermatogenesis. ..
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    Kleiman S, Yogev L, Hauser R, Botchan A, Bar Shira Maymon B, Schreiber L, et al. Members of the CDY family have different expression patterns: CDY1 transcripts have the best correlation with complete spermatogenesis. Hum Genet. 2003;113:486-92 pubmed
    ..However, in consideration of the high levels of identity between CDY1 and CDY2 (98% at the protein level), the delayed up-regulation of CDY1 transcripts could be attributable to temporal changes in dosage requirements. ..
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    Kleiman S, Yogev L, Hauser R, Botchan A, Maymon B, Paz G, et al. Expression profile of AZF genes in testicular biopsies of azoospermic men. Hum Reprod. 2007;22:151-8 pubmed
    ..The findings contribute to the search and selection of the most valuable gene markers potentially useful as additional tools for predicting complete spermatogenesis by multiplex expression analysis. ..
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    Kleiman S, Bar Shira Maymon B, Hauser R, Botchan A, Paz G, Yavetz H, et al. Histone H4 acetylation and AZFc involvement in germ cells of specimens of impaired spermatogenesis. Fertil Steril. 2008;89:1728-36 pubmed
    ..Spermatids Hypac-H4 impairment in mixed atrophy did not deteriorate further by AZFc region deletion. ..
  8. Kleiman S, Lehavi O, Hauser R, Botchan A, Paz G, Yavetz H, et al. CDY1 and BOULE transcripts assessed in the same biopsy as predictive markers for successful testicular sperm retrieval. Fertil Steril. 2011;95:2297-302, 2302.e1 pubmed publisher
    ..3%. Assessing the expression of both CDY1 and BOULE by qualitative RT-PCR is a sensitive and feasible test for predicting the presence of sperm cells in testicular tissue and may serve as a predictive tool if repeated TESE is required. ..
  9. Kleiman S, Almog R, Yogev L, Hauser R, Lehavi O, Paz G, et al. Screening for partial AZFa microdeletions in the Y chromosome of infertile men: is it of clinical relevance?. Fertil Steril. 2012;98:43-7 pubmed publisher
    ..To evaluate the frequency of complete and partial AZFa Y-chromosome microdeletions among infertile Israeli men. To review the published frequencies and histologic findings of AZFa deletions...