Gili Kenet

Summary

Country: Israel

Publications

  1. doi request reprint Neonatal IVH--mechanisms and management
    Gili Kenet
    Thrombosis Unit, National Hemophilia Center, Sheba Medical Center, Tel Hashomer, Israel
    Thromb Res 127:S120-2. 2011
  2. pmc Cerebral venous thrombosis in the mediterranean area in children
    S Menascu
    Department of Pediatric Neurology, The Edmond and Lily Safra Children s Hospital, Sheba Medical Center, Tel Hashomer and the Sackler Medical School, Tel Aviv University, Israel
    Mediterr J Hematol Infect Dis 3:e2011029. 2011
  3. ncbi request reprint Venous thromboembolism in neonates and children
    Gili Kenet
    The Israel National Hemophilia Centre, Thrombosis Unit, Sheba Medical Centre, The Sackler Medical School, Tel Aviv University, Tel Hashomer Israel
    Best Pract Res Clin Haematol 25:333-44. 2012
  4. doi request reprint Factor v Leiden and antiphospholipid antibodies in either mothers or infants increase the risk for perinatal arterial ischemic stroke
    Michal J Simchen
    Thrombosis Unit, National Hemophilia Center, Sheba Medical Center, Tel Hashomer, Israel
    Stroke 40:65-70. 2009
  5. ncbi request reprint Single-dose recombinant activated factor VII therapy in hemophilia patients with inhibitors
    Gili Kenet
    The Israeli National Hemophilia Center, Institute of Thrombosis and Hemostasis, Sheba Medical Center, Tel Hashomer, Israel
    Semin Hematol 45:S38-41. 2008
  6. doi request reprint Lower doses of rFVIIa therapy are safe and effective for surgical interventions in patients with severe FXI deficiency and inhibitors
    G Kenet
    Thrombosis Unit, The Israeli National Hemophilia Center, The Institute of Thrombosis and Hemophilia, Sheba Medical Center, Tel Hashomer, Israel
    Haemophilia 15:1065-73. 2009
  7. doi request reprint Bleeding disorders in neonates
    G Kenet
    Thrombosis Unit, National Hemophilia Center, Sheba Medical Center, Tel Hashomer, Israel
    Haemophilia 16:168-75. 2010
  8. ncbi request reprint Fetal and neonatal thrombophilia
    Gili Kenet
    Pediatric Coagulation Service, Sheba Medical Center, Tel Hashomer, Israel 52621
    Obstet Gynecol Clin North Am 33:457-66. 2006
  9. ncbi request reprint High-dose recombinant factor VIIa therapy in hemophilia patients with inhibitors
    Gili Kenet
    The Israeli National Hemophilia Center, Sheba Medical Center, Tel Hashomer, Israel
    Semin Hematol 43:S108-10. 2006
  10. ncbi request reprint Surfactant impairs coagulation in-vitro: a risk factor for pulmonary hemorrhage?
    Tzipora Strauss
    The Department of Neonatology, Edmond and Lily Safra Medical Center, Tel Hashomer, Israel The Sackler Medical School, Tel Aviv University, Israel
    Thromb Res 132:599-603. 2013

Collaborators

Detail Information

Publications35

  1. doi request reprint Neonatal IVH--mechanisms and management
    Gili Kenet
    Thrombosis Unit, National Hemophilia Center, Sheba Medical Center, Tel Hashomer, Israel
    Thromb Res 127:S120-2. 2011
    ..The following manuscript will address the epidemiology and pathogenesis of IVH and review studies regarding potential pro-coagulant therapy...
  2. pmc Cerebral venous thrombosis in the mediterranean area in children
    S Menascu
    Department of Pediatric Neurology, The Edmond and Lily Safra Children s Hospital, Sheba Medical Center, Tel Hashomer and the Sackler Medical School, Tel Aviv University, Israel
    Mediterr J Hematol Infect Dis 3:e2011029. 2011
    ..However, morbidity and mortality are significant, highlighting the continued need for high-quality studies within this field. The following review will highlight aspects of CSVT in the mediteranian area in children...
  3. ncbi request reprint Venous thromboembolism in neonates and children
    Gili Kenet
    The Israel National Hemophilia Centre, Thrombosis Unit, Sheba Medical Centre, The Sackler Medical School, Tel Aviv University, Tel Hashomer Israel
    Best Pract Res Clin Haematol 25:333-44. 2012
    ..42% (0.12-0.53%) for factor II G202010A, 0.25% (0.12-0.53%) for factor V G1691A, and 0.10% (0.06-0.17%) in relatives with no IT. Based on these data diagnosis, screening and treatment issues will be discussed...
  4. doi request reprint Factor v Leiden and antiphospholipid antibodies in either mothers or infants increase the risk for perinatal arterial ischemic stroke
    Michal J Simchen
    Thrombosis Unit, National Hemophilia Center, Sheba Medical Center, Tel Hashomer, Israel
    Stroke 40:65-70. 2009
    ..The objective was to investigate the role of infant and maternal thrombophilia in a cohort of mothers and infants presenting with perinatal arterial ischemic stroke...
  5. ncbi request reprint Single-dose recombinant activated factor VII therapy in hemophilia patients with inhibitors
    Gili Kenet
    The Israeli National Hemophilia Center, Institute of Thrombosis and Hemostasis, Sheba Medical Center, Tel Hashomer, Israel
    Semin Hematol 45:S38-41. 2008
    ..Further research should contribute towards more effective dose optimization of rFVIIa in hemophilic inhibitor patients...
  6. doi request reprint Lower doses of rFVIIa therapy are safe and effective for surgical interventions in patients with severe FXI deficiency and inhibitors
    G Kenet
    Thrombosis Unit, The Israeli National Hemophilia Center, The Institute of Thrombosis and Hemophilia, Sheba Medical Center, Tel Hashomer, Israel
    Haemophilia 15:1065-73. 2009
    ..Recombinant FVIIa at low doses may effectively induce haemostasis and seems to be a safe treatment mode in patients with FXI deficiency and inhibitors undergoing surgeries...
  7. doi request reprint Bleeding disorders in neonates
    G Kenet
    Thrombosis Unit, National Hemophilia Center, Sheba Medical Center, Tel Hashomer, Israel
    Haemophilia 16:168-75. 2010
    ..This manuscript discusses the unique aspects of clinical presentation, laboratory assessment, and treatment of various bleeding disorders in neonates...
  8. ncbi request reprint Fetal and neonatal thrombophilia
    Gili Kenet
    Pediatric Coagulation Service, Sheba Medical Center, Tel Hashomer, Israel 52621
    Obstet Gynecol Clin North Am 33:457-66. 2006
    ..Further attention and larger prospective studies are required to establish the role of thrombophilic risk factors in the pathogenesis of any other perinatal complications...
  9. ncbi request reprint High-dose recombinant factor VIIa therapy in hemophilia patients with inhibitors
    Gili Kenet
    The Israeli National Hemophilia Center, Sheba Medical Center, Tel Hashomer, Israel
    Semin Hematol 43:S108-10. 2006
    ..However, it is hoped that further research will support these favorable observations and thus contribute towards more effective dose optimization of rFVIIa in hemophilic inhibitor patients...
  10. ncbi request reprint Surfactant impairs coagulation in-vitro: a risk factor for pulmonary hemorrhage?
    Tzipora Strauss
    The Department of Neonatology, Edmond and Lily Safra Medical Center, Tel Hashomer, Israel The Sackler Medical School, Tel Aviv University, Israel
    Thromb Res 132:599-603. 2013
    ..Impaired thrombin generation and poor clot formation in premature neonates affect PHEM severity...
  11. doi request reprint The impact of genetic and environmental factors on homocysteine levels in preterm neonates
    Ayala Maayan-Metzger
    Department of Neonatology, Edmond and Lily Safra Children s Hospital, Sheba Medical Center, Tel Hashomer, Israel
    Pediatr Blood Cancer 60:659-62. 2013
    ..Data were collected on maternal history and delivery as well as on post-natal complications...
  12. doi request reprint Severe factor X deficiency in three unrelated Palestinian patients is caused by homozygosity for the mutation c302delG-correlation with thrombin generation and thromboelastometry
    Tami Livnat
    Institute of Thrombosis and Hemostasis Sheba Medical Center, Tel Hashomer and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    Blood Coagul Fibrinolysis 22:673-9. 2011
    ..Thrombin generation can also serve for monitoring and optimizing treatment. The correlation of thromboelastometry assay and severe FX deficiency is less striking...
  13. doi request reprint Impaired platelet function and peripartum bleeding in women with Gaucher disease
    Michal J Simchen
    Department of Obstetrics and Gynecology, Sheba Medical Center, Tel Hashomer, Israel
    Thromb Haemost 105:509-14. 2011
    ..7% of those with normal CPA platelet function tests (OR 11.6, 95% CI 1.7-77.7, p=0.018). In conclusion, women with type 1 Gaucher disease who have abnormal platelet function tests may have an increased risk of PPH...
  14. doi request reprint A highly sensitive thrombin generation assay for assessment of recombinant activated factor VII therapy in haemophilia patients with an inhibitor
    Tami Livnat
    The National Haemophilia Center Sheba Medical Center, Tel Hashomer, and the Sackler School of Medicine, Tel Aviv University, Israel
    Thromb Haemost 105:688-95. 2011
    ....
  15. doi request reprint Point of care testing in children undergoing cardiopulmonary bypass
    Tal Tirosh-Wagner
    Department of Pediatrics of the Edmond and Lily Safra Children s Hospital, Affiliated to Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    Pediatr Blood Cancer 56:794-8. 2011
    ..The aim of this study was to define the potential role of the cone and platelet analyzer (CPA) and the rotating thromboelastogram (ROTEM) point of care tests in children undergoing CPB...
  16. doi request reprint Hemostasis and thrombosis in critically ill children
    Gili Kenet
    The Thrombosis Unit, National Hemophilia Center, Sheba Medical Center, Tel Hashomer, Israel
    Semin Thromb Hemost 34:451-8. 2008
    ..The conditions, risk factors, and therapeutic options available for critically ill PICU patients are discussed in this review...
  17. ncbi request reprint Possible role of recombinant activated factor VII (rFVIIa) in the control of hemorrhage associated with massive trauma
    Uri Martinowitz
    National Hemophilia Center, Tel Hashomer, Israel
    Can J Anaesth 49:S15-20. 2002
    ..It is approved for use in hemophilia patients, however, its use in trauma is still controversial due to the theoretical risk of thromboembolic complications...
  18. ncbi request reprint Recombinant activated factor VII for life-threatening pulmonary hemorrhage after pediatric cardiac surgery
    Leah Leibovitch
    Department of Pediatric Intensive Care and Pediatric Cardiac Surgery, Tel Aviv University, Tel Aviv, Israel
    Pediatr Crit Care Med 4:444-6. 2003
    ..To report intractable life-threatening pulmonary hemorrhage after cardiac surgery in an infant who was treated successfully with recombinant activated factor VII (rFVIIa)...
  19. ncbi request reprint Thrombophilia and pregnancy complications
    Benjamin Brenner
    Thrombosis and Hemostasis Unit, Department of Hematology, Rambam Medical Center, PO Box 9602, Hiafa 31096, Israel
    Thromb Haemost 92:678-81. 2004
    ..Maternal antithrombotic therapy is currently evaluated in women with thrombophilia and previous complications...
  20. ncbi request reprint Chitosan-based dressing for the treatment of external/accessible bleedings in children with bleeding tendency
    Mudi Misgav
    National Hemophilia Center and Center of Thrombosis, The Chaim Sheba Medical Center, Tel Hashomer, Sackler Faculty of Medicine, Tel Aviv University, Israel
    J Pediatr Hematol Oncol 36:140-2. 2014
    ..Bleeding episodes in patients with congenital or acquired bleeding disorders are usually managed with factor concentrates or blood products. However, external and accessible bleeds may effectively be managed with topical hemostasis...
  21. pmc Risk factors for recurrent venous thromboembolism in the European collaborative paediatric database on cerebral venous thrombosis: a multicentre cohort study
    Gili Kenet
    Israel National Haemophilia Centre, Sheba Medical Centre, Tel Hashomer, Israel
    Lancet Neurol 6:595-603. 2007
    ....
  22. ncbi request reprint Paediatric cerebral sinus vein thrombosis. A multi-center, case-controlled study
    Gili Kenet
    The Israeli National Hemophilia Center, Sheba Medical Center, Tel Hashomer, 52621, Israel
    Thromb Haemost 92:713-8. 2004
    ..Thus, those selected patients would benefit most from thrombophilia work-up, required for long-term therapy considerations...
  23. doi request reprint Predictors for neonatal thrombocytopenia in infants of thrombocytopenic mothers during pregnancy
    Ayala Maayan-Metzger
    Department of Neonatology, The Edmond and Lili Safra Children s Hospital, Sheba Medical Center and Sackler Faculty of Medicine, Tel Aviv University, Tel Hashomer, Israel
    Pediatr Blood Cancer 55:145-8. 2010
    ..Although maternal thrombocytopenia during pregnancy is common, its effect on neonatal platelets has not yet been fully evaluated...
  24. doi request reprint Influence of factor 5 rs6025 and factor 2 rs1799963 mutation on inhibitor development in patients with hemophilia A--an Israeli-German multicenter database study
    Gili Kenet
    Thrombosis Unit, National Hemophilia Center, Tel Hashomer and the Sackler Medical School, Tel Aviv University, Israel
    Thromb Res 133:544-9. 2014
    ..The present cohort study was performed to investigate the impact of the factor 5 rs6025 [F5] and the factor 2 rs1799963 [F2] mutations on high-titer inhibitor development [HRI] in patients with severe/moderate-severe hemophilia A [HA]...
  25. ncbi request reprint Characterization of seven novel mutations causing factor XI deficiency
    Michal Zucker
    The Amalia Biron Research Institute of Thrombosis and Hemostasis, Chaim Sheba Medical Center, Tel Hashomer and Sackler Faculty of Medicine, Tel Aviv University, Israel
    Haematologica 92:1375-80. 2007
    ..The objective of this study was to identify the mutations in 15 unrelated FXI-deficient patients and characterize missense mutations by expression in baby hamster kidney (BHK) cells...
  26. doi request reprint Fibrinoid reaction after lens extraction in rabbit eyes
    Guy J Ben Simon
    Goldschleger Eye Institute, Sheba Medical Center, Tel Hashomer, Israel
    J Cataract Refract Surg 38:890-3. 2012
    ....
  27. doi request reprint Impact of persistent antiphospholipid antibodies on risk of incident symptomatic thromboembolism in children: a systematic review and meta-analysis
    Gili Kenet
    The Israel National Haemophilia Centre, Sheba Medical Centre, Tel Hashomer, Israel
    Semin Thromb Hemost 37:802-9. 2011
    ..9/2.2-10.9). The present meta-analysis indicates that detection of persistent aPL is clinically meaningful in children with, or at risk for, TE and underscores the importance of pediatric thrombophilia screening programs...
  28. ncbi request reprint Thrombophilia does not increase risk for neonatal complications in preterm infants
    Gili Kenet
    The Pediatric Coagulation Service, Institute of Thrombosis and Hemostasis, Sackler School of Medicine, Tel Aviv University, Israel
    Thromb Haemost 90:823-8. 2003
    ..564). Our data suggest that preterm infants with thrombophilia are not at increased risk for developing neonatal complications...
  29. ncbi request reprint Thrombophilia in children with venous thromboembolic disease
    Shoshana Revel-Vilk
    Pediatric Hematology Oncology Unit, Hadassah Hebrew University Medical Center, POB 12000, Jerusalem il 91200, Israel
    Thromb Res 118:59-65. 2006
    ....
  30. ncbi request reprint Home treatment of haemarthroses using a single dose regimen of recombinant activated factor VII in patients with haemophilia and inhibitors. A multi-centre, randomised, double-blind, cross-over trial
    Khan Kavakli
    University of Ege, Izmir, Turkey
    Thromb Haemost 95:600-5. 2006
    ..No safety issues were identified. Administration of rFVIIa as a single 270 microg/kg dose to treat haemarthroses in patients with haemophilia and inhibitors was at least as efficacious and safe as the 90 microg/kg x 3 regimen...
  31. ncbi request reprint Role of thrombophilic risk factors in children with non-stroke cerebral palsy
    Aviva Fattal-Valevski
    The Institute for Child Development and Pediatric Neurology Unit, Tel Aviv Sourasky Medical Center, Beit Habriut Strauss, 14 Balfour St, Tel Aviv 65211, Israel
    Thromb Res 116:133-7. 2005
    ..Thrombophilic risk factors play an important role in the pathogenesis of perinatal stroke and resultant cerebral palsy (CP). The association between thrombophilia and CP caused by etiologies other than stroke is undetermined...
  32. ncbi request reprint Bleeding and thrombosis issues in pediatric patients: current approach to diagnosis and treatment
    Gili Kenet
    Acta Haematol 115:137-40. 2006
  33. pmc Promoter polymorphisms in the plasma glutathione peroxidase (GPx-3) gene: a novel risk factor for arterial ischemic stroke among young adults and children
    Barbara Voetsch
    Whitaker Cardiovascular Institute and Evans Department of Medicine, Boston University School of Medicine, Boston, MA, USA
    Stroke 38:41-9. 2007
    ..The aim of this study is to identify polymorphisms in the GPx-3 gene, examine their relationship to arterial ischemic stroke (AIS) in a large series of children and young adults, and determine their functional molecular consequences...
  34. ncbi request reprint Recombinant factor VIIa for treatment of a child with severe factor VII deficiency and coarctation of the aorta
    Michal Maimon
    J Pediatr Hematol Oncol 25:591. 2003
  35. doi request reprint Impact of inherited thrombophilia on venous thromboembolism in children: a systematic review and meta-analysis of observational studies
    Guy Young
    Division of Hematology Oncology, Children s Hospital Los Angeles, Los Angeles, CA, USA
    Circulation 118:1373-82. 2008
    ..The aim of the present study was to estimate the impact of inherited thrombophilia (IT) on the risk of venous thromboembolism (VTE) onset and recurrence in children by a meta-analysis of published observational studies...