Z Hochberg

Summary

Country: Israel

Publications

  1. doi request reprint Hormone resistance at the clinical level
    Ze ev Hochberg
    Division of Pediatric Endocrinology, Meyer Children s Hospital, Rambam Medical Center, and Rappaport Family Faculty of Medicine and Research Institute, Technion Israel Institute of Technology, Haifa, Israel
    Sci Signal 3:pt1. 2010
  2. pmc Evolutionary perspective in child growth
    Ze ev Hochberg
    Meyer Children s Hospital, Rambam Medical Center, and Rappaport Family Faculty of Medicine and Research Institute, Technion Israel Institute of Technology, Haifa, Israel
    Rambam Maimonides Med J 2:e0057. 2011
  3. pmc Developmental plasticity in child growth and maturation
    Ze ev Hochberg
    Rappaport Family Faculty of Medicine and Research Institute, Technion Israel Institute of Technology Haifa, Israel
    Front Endocrinol (Lausanne) 2:41. 2011
  4. pmc Proteins related to lipoprotein profile were identified using a pharmaco-proteomic approach as markers for growth response to growth hormone (GH) treatment in short prepubertal children
    Bjorn Andersson
    Goteborg Pediatric Growth Research Center, Department of Pediatrics, Institute of Clinical Sciences, University of Gothenburg, Sweden
    Proteome Sci 7:40. 2009
  5. pmc Evolutionary medicine - the quest for a better understanding of health, disease and prevention
    Martin Brune
    Division of Cognitive Neuropsychiatry and Psychiatric Preventive Medicine, LWL University Hospital, Ruhr University Bochum, Alexandrinenstrasse 1, Bochum, D 44791, Germany
    BMC Med 11:116. 2013
  6. pmc Effects of breastfeeding on body composition and maturational tempo in the rat
    Yonatan Crispel
    Division of Pediatric Endocrinology, Meyer Children s Hospital, Rambam Health Care Campus, Haaliya Street, Haifa 31096, Israel
    BMC Med 11:114. 2013
  7. pmc Evo-devo of human adolescence: beyond disease models of early puberty
    Ze ev Hochberg
    Division of Pediatric Endocrinology, Meyer Children s Hospital, Rambam Health Care Campus, Haaliya Street, Haifa 31096, Israel
    BMC Med 11:113. 2013
  8. pmc Evolutionary fitness as a function of pubertal age in 22 subsistence-based traditional societies
    Ze ev Hochberg
    Division of Pediatric Endocrinology, Meyer Children s Hospital, Rambam Medical Center, and Rappaport Faculty of Medicine and Research Institute, Technion Israel Institute of Technology, Haifa, Israel
    Int J Pediatr Endocrinol 2011:2. 2011
  9. ncbi request reprint Vitamin-D-dependent rickets type 2
    Ze ev Hochberg
    Department of Pediatrics, Meyer Children s Hospital, Rambam Medical Center, Haifa, Israel
    Horm Res 58:297-302. 2002
  10. doi request reprint Evo-devo of infantile and childhood growth
    Ze ev Hochberg
    Meyer Children s Hospital, POB 9602, Haifa 31096, Israel
    Pediatr Res 64:2-7. 2008

Collaborators

Detail Information

Publications50

  1. doi request reprint Hormone resistance at the clinical level
    Ze ev Hochberg
    Division of Pediatric Endocrinology, Meyer Children s Hospital, Rambam Medical Center, and Rappaport Family Faculty of Medicine and Research Institute, Technion Israel Institute of Technology, Haifa, Israel
    Sci Signal 3:pt1. 2010
    ..The presentation also shows how careful phenotyping of such patients has triggered decades of translational research...
  2. pmc Evolutionary perspective in child growth
    Ze ev Hochberg
    Meyer Children s Hospital, Rambam Medical Center, and Rappaport Family Faculty of Medicine and Research Institute, Technion Israel Institute of Technology, Haifa, Israel
    Rambam Maimonides Med J 2:e0057. 2011
    ..Fundamental questions are raised by a life-history approach to the unique growth pattern of each child in his given genetic background and current environment. ..
  3. pmc Developmental plasticity in child growth and maturation
    Ze ev Hochberg
    Rappaport Family Faculty of Medicine and Research Institute, Technion Israel Institute of Technology Haifa, Israel
    Front Endocrinol (Lausanne) 2:41. 2011
    ..It involves epigenetic responses to environmental changes, which exert their effects during life history phase transitions...
  4. pmc Proteins related to lipoprotein profile were identified using a pharmaco-proteomic approach as markers for growth response to growth hormone (GH) treatment in short prepubertal children
    Bjorn Andersson
    Goteborg Pediatric Growth Research Center, Department of Pediatrics, Institute of Clinical Sciences, University of Gothenburg, Sweden
    Proteome Sci 7:40. 2009
    ..Cross-validated regression and random permutation analyses were performed to identify significant correlations between protein expression patterns and the 2-year growth response to GH treatment...
  5. pmc Evolutionary medicine - the quest for a better understanding of health, disease and prevention
    Martin Brune
    Division of Cognitive Neuropsychiatry and Psychiatric Preventive Medicine, LWL University Hospital, Ruhr University Bochum, Alexandrinenstrasse 1, Bochum, D 44791, Germany
    BMC Med 11:116. 2013
    ....
  6. pmc Effects of breastfeeding on body composition and maturational tempo in the rat
    Yonatan Crispel
    Division of Pediatric Endocrinology, Meyer Children s Hospital, Rambam Health Care Campus, Haaliya Street, Haifa 31096, Israel
    BMC Med 11:114. 2013
    ..We have previously shown that the infant-to-childhood transition reflects the adaptive adjustment of an individual's size to the prevailing and anticipated environment...
  7. pmc Evo-devo of human adolescence: beyond disease models of early puberty
    Ze ev Hochberg
    Division of Pediatric Endocrinology, Meyer Children s Hospital, Rambam Health Care Campus, Haaliya Street, Haifa 31096, Israel
    BMC Med 11:113. 2013
    ..Here we explore implications of an evolutionary-developmental-endocrinological-anthropological framework for theory building, while illuminating new directions for research...
  8. pmc Evolutionary fitness as a function of pubertal age in 22 subsistence-based traditional societies
    Ze ev Hochberg
    Division of Pediatric Endocrinology, Meyer Children s Hospital, Rambam Medical Center, and Rappaport Faculty of Medicine and Research Institute, Technion Israel Institute of Technology, Haifa, Israel
    Int J Pediatr Endocrinol 2011:2. 2011
    ....
  9. ncbi request reprint Vitamin-D-dependent rickets type 2
    Ze ev Hochberg
    Department of Pediatrics, Meyer Children s Hospital, Rambam Medical Center, Haifa, Israel
    Horm Res 58:297-302. 2002
    ....
  10. doi request reprint Evo-devo of infantile and childhood growth
    Ze ev Hochberg
    Meyer Children s Hospital, POB 9602, Haifa 31096, Israel
    Pediatr Res 64:2-7. 2008
    ....
  11. doi request reprint Juvenility in the context of life history theory
    Z Hochberg
    Meyer Children s Hospital, Rambam Medical Center and Technion Israel Institute of Technology, Haifa, Israel
    Arch Dis Child 93:534-9. 2008
    ..The data presented suggest that this period is endowed with programming/predictive adaptive responses of body composition to the environment...
  12. ncbi request reprint Hypothalamic regulation of adiposity: the role of 11beta-hydroxysteroid dehydrogenase type 1
    Z Hochberg
    Division of Endocrinology, Meyer Children s Hospital, PO Box 9602, Rambam Medical Center, Haifa 31096, Israel
    Horm Metab Res 36:365-9. 2004
    ..Inhibition of 11beta-HSD-1 suppresses preadipocyte differentiation into mature adipocytes, and may provide a therapeutic tool...
  13. ncbi request reprint Mechanisms of steroid impairment of growth
    Ze ev Hochberg
    Pediatric Endocrinology, Meyer Children s Hospital, Haifa, Israel
    Horm Res 58:33-8. 2002
    ....
  14. doi request reprint Evo-devo of child growth II: human life history and transition between its phases
    Ze ev Hochberg
    Meyer Children s Hospital, Rambam Medical Center, and Technion Israel Institute of Technology, PO Box 9602, Haifa 31096, Israel
    Eur J Endocrinol 160:135-41. 2009
    ..Transition to adolescence entails plasticity in adapting to energy resources, other environmental cues, and the social needs of the maturing adolescent to determine lifespan and the period of fecundity and fertility...
  15. ncbi request reprint Consensus development for the supplementation of vitamin D in childhood and adolescence
    Ze ev Hochberg
    Meyer Children Hospital, Haifa, Israel
    Horm Res 58:39-51. 2002
  16. pmc Child health, developmental plasticity, and epigenetic programming
    Z Hochberg
    Rambam Medical Center, Rappaport Faculty of Medicine and Research Institute, Technion Israel Institute of Technology, Haifa, Israel
    Endocr Rev 32:159-224. 2011
    ....
  17. ncbi request reprint Differences in infantile growth patterns in Turner syndrome girls with and without spontaneous puberty
    Z Hochberg
    Division of Endocrinology, Meyer Children s Hospital, Haifa, Israel
    Horm Metab Res 37:236-41. 2005
    ..The hypothesis was that TS patients with normal prepubertal estrogen levels would have a different growth pattern from those with subnormal estrogen levels...
  18. ncbi request reprint Endocrine complications of thalassemia
    D Tiosano
    Department of Pediatrics, Rambam Medical Center, Haifa, Israel
    J Endocrinol Invest 24:716-23. 2001
    ..Endocrine abnormalities should be monitored carefully and a thorough endocrine evaluation should be carried out yearly in every patients to detect subclinical endocrinopaties...
  19. ncbi request reprint The role of the vitamin D receptor in regulating vitamin D metabolism: a study of vitamin D-dependent rickets, type II
    D Tiosano
    Department of Pediatrics, Rambam Medical Center, Haifa 31096, Israel
    J Clin Endocrinol Metab 86:1908-12. 2001
    ..Assessment of the influence of 1,25-(OH)(2)D shows reciprocal control of enzyme activity in man, suppressing 1-OHase and stimulating 24-OHase activity...
  20. doi request reprint In vitro fertilisation and use of ovulation enhancers may both influence childhood height in very low birthweight infants
    I R Makhoul
    Department of Neonatology, Rambam Health Care Campus, Rambam Medical Center, Bat Galim, Haifa, Israel
    Arch Dis Child Fetal Neonatal Ed 94:F355-9. 2009
    ..Term-born children conceived by in vitro fertilisation (IVF) are reportedly taller than naturally conceived (NC) children. High levels of growth promoting hormones and epigenetic imprinting have been suggested as pathogenetic mechanisms...
  21. doi request reprint Expanding the definition of hypothalamic obesity
    I Hochberg
    Rambam Medical Center and Rappaport Family Faculty of Medicine and Research Institute, Technion Israel Institute of Technology, Haifa, Israel
    Obes Rev 11:709-21. 2010
    ..We review the studies evaluating possible treatment strategies, including sympathomimetics, somatostatin analogues, triiodothyronine, sibutramine, and surgery...
  22. ncbi request reprint The importance of adrenocortical glucocorticoids for adrenomedullary and physiological response to stress: a study in isolated glucocorticoid deficiency
    N Zuckerman-Levin
    Department of Pediatrics, Rambam Medical Center, Haifa 31096, Israel
    J Clin Endocrinol Metab 86:5920-4. 2001
    ..The implications of the pressor response to exercise, the declining pulse pressure, and the increased pulse response insinuate a lower physical fitness in patients with adrenal insufficiency...
  23. ncbi request reprint Choosing an oestrogen replacement therapy in young adult women with Turner syndrome
    H Guttmann
    Department of Paediatrics, Rambam Medical Center, Haifa, Israel
    Clin Endocrinol (Oxf) 54:159-64. 2001
    ..In the short term, neither regimen is effective for bone turnover in adult women with Turner syndrome...
  24. ncbi request reprint Metabolomics of the obese
    Z Hochberg
    Meyer Children s Hospital, Technion Israel Institute of Technology, Haifa, Israel
    Int J Obes (Lond) 30:S4. 2006
  25. ncbi request reprint The autosomal dominant trait of obesity, acanthosis nigricans, hypertension, ischemic heart disease and diabetes type 2
    N Kerem
    Department of Pediatrics, Rambam Medical Center, Haifa, Israel
    Horm Res 55:298-304. 2001
    ..It is recommended that such children should be followed up as an 'at-risk' group, and would probably benefit from intensive weight reduction, which may prevent the later manifestations of the syndrome...
  26. ncbi request reprint The role of catecholamines in estradiol and progesterone secretion by cultured explants and cells of human term placentae
    E R Barnea
    Feto Placental Endocrinology Unit, Rambam Medical Centre, Haifa, Israel
    Acta Endocrinol (Copenh) 121:767-72. 1989
    ..The marked response of the explant system as compared with the marginal response of the cell culture system indicates that cell to cell contact/communication is required for full expression of catecholamine effect...
  27. ncbi request reprint Bone health in eating disorders
    N Zuckerman-Levin
    Eating Disorders Clinic, Psychiatric Division, Rambam Medical Center, Haifa, Israel
    Obes Rev 15:215-23. 2014
    ..Treatment modalities involving hormonal therapies have limited effectiveness, whereas increased caloric intake, weight gain and resumption of menses are essential to improved BMD. ..
  28. ncbi request reprint Shedding of growth hormone-binding protein is inhibited by hydroxamic acid-based protease inhibitors: proposed mechanism of activation of growth hormone-binding protein secretase
    T Amit
    Department of Pharmacology, Bruce Rappaport Faculty of Medicine, Technion, Haifa, Israel
    J Endocrinol 169:397-407. 2001
    ..In the long run, specific inhibitors of these processes could be applied in the regulation of GHBP levels and, thus, of GH availability and/or activity...
  29. ncbi request reprint A membrane-fixed, truncated isoform of the human growth hormone receptor
    T Amit
    Department of Pharmacology, Bruce Rappaport Faculty of Medicine, Technion, Haifa, Israel
    J Clin Endocrinol Metab 82:3813-7. 1997
    ..The relative abundance of these two hGHR isoforms, through regulation of splicing, could be of critical importance in modulating the biological effects of GH...
  30. ncbi request reprint Growth in early life and its relation to pubertal growth
    Zhong Cheng Luo
    Clinical Trials Centre and Department of Pediatrics, University of Hong Kong, Pokfulam, The P R China
    Epidemiology 14:65-73. 2003
    ..The timing and magnitude of pubertal growth in relation to fetal, infancy and childhood growth have not been explored...
  31. ncbi request reprint [A child's growth mirrors health and illness. Regular measurement of body height is an important diagnostic tool]
    Lars Gelander
    Centrum för pediatrisk tillväxtforskning, Institutet för kvinnors och barns hälsa, Göteborgs Universitet
    Lakartidningen 99:162-4. 2002
    ..Systematic assessment of each measuring may serve as an aid to detect abnormal growth and thereby facilitate a correct diagnosis...
  32. pmc Models predicting the growth response to growth hormone treatment in short children independent of GH status, birth size and gestational age
    Jovanna Dahlgren
    Goteborg Pediatric Growth Research Center, Institute of Clinical Science, The Sahlgrenska Academy at Goteborg University, Goteborg, Sweden
    BMC Med Inform Decis Mak 7:40. 2007
    ..As the GH doses are included, these models can be used to individualize treatment...
  33. ncbi request reprint Effect of gastric bypass on spontaneous growth hormone and ghrelin release profiles
    Marcio C Mancini
    Obesity and Metabolic Syndrome Unit, Endocrinology Service, Hospital das Clinicas, Sao Paulo University School of Medicine, Sao Paulo, Brazil
    Obesity (Silver Spring) 14:383-7. 2006
    ....
  34. ncbi request reprint Spontaneous growth hormone secretory characteristics in children with partial growth hormone insensitivity
    Ragnar Bjarnason
    Department of Endocrinology, St Bartholomew s and the Royal London School of Medicine and Dentistry, UK
    Clin Endocrinol (Oxf) 57:357-61. 2002
    ..Their molecular defect consists of inclusion of a mutant intronic pseudoexon in the region of the GH receptor involved in homodimerization...
  35. ncbi request reprint Early spontaneous catch-up growth
    Johan Karlberg
    Clinical Trials Centre, Faculty of Medicine, The University of Hong Kong Hong Kong SAR, PR China
    J Pediatr Endocrinol Metab 15:1243-55. 2002
    ....
  36. ncbi request reprint A growth prediction model for short children born small for gestational age
    Michael B Ranke
    Paediatric Endocrinology Section, University Children s Hospital, Tubingen, Germany
    J Pediatr Endocrinol Metab 15:1273. 2002
  37. ncbi request reprint Pubertal growth assessment
    Johan Karlberg
    Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China
    Horm Res 60:27-35. 2003
    ..80 for both sexes. Finally, a method for assessing total pubertal height gain is presented. The method adjusts for the timing of puberty and is based on the height and age at pubertal onset, plus the observed final height...
  38. ncbi request reprint The KIGS experience with the addition of gonadotropin-releasing hormone agonists to growth hormone (GH) treatment of children with idiopathic GH deficiency
    Edward O Reiter
    Baystate Medical Center Children s Hospital, Tufts University School of Medicine Springfield, MA 01199, USA
    Horm Res 60:68-73. 2003
    ..These data suggest that the attainment of a substantial height SDS by manipulating the tempo of puberty is limited, but that optimizing growth during the pre-pubertal phase is a more important factor...
  39. ncbi request reprint Insulin-like growth factors as diagnostic tools in growth hormone deficiency during childhood and adolescence: the KIGS experience
    Michael B Ranke
    Paediatric Endocrinology Section, University Children s Hospital, Tubingen, Germany
    Horm Res 62:17-25. 2004
    ....
  40. ncbi request reprint Bone age progression during the first year of growth hormone therapy in pre-pubertal children with idiopathic growth hormone deficiency, Turner syndrome or idiopathic short stature, and in short children born small for gestational age: analysis of data fr
    Feyza Darendeliler
    Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey
    Horm Res 63:40-7. 2005
    ....
  41. ncbi request reprint GH secretory pattern in young adults who discontinued GH treatment for GH deficiency and decreased longitudinal growth in childhood
    Johan Svensson
    Research Centre for Endocrinology and Metabolism, Sahlgrenska University Hospital, Goteborg, Sweden
    Eur J Endocrinol 155:91-9. 2006
    ..Sixteen matched healthy controls were also studied. All blood samples were analysed using an ultrasensitive GH assay and then, approximate entropy (ApEn) and deconvolution analysis were performed...
  42. ncbi request reprint Major determinants of height development in Turner syndrome (TS) patients treated with GH: analysis of 987 patients from KIGS
    Michael B Ranke
    Paediatric Endocrinology Section, Children s Hospital, University of Tuebingen, D 72076 Tuebingen, Germany
    Pediatr Res 61:105-10. 2007
    ..Evidently, height at GH start (the taller, the better), age at GH start (the younger, the better), the responsiveness to GH (the higher, the better) and age at puberty (the later, the better) determine NAH...
  43. ncbi request reprint Insulin-like growth factor-1, leptin, body composition, and clinical status interactions in children with cystic fibrosis
    Margaret C S Boguszewski
    Pediatric Endocrinology Unit, Department of Pediatrics, Hospital de Clinicas, Federal University of Parana, Curitiba, Brazil
    Horm Res 67:250-6. 2007
    ..To evaluate the relationships between disease activity, body composition, IGF-1 and leptin concentrations in CF children...
  44. ncbi request reprint Age at growth hormone therapy start and first-year responsiveness to growth hormone are major determinants of height outcome in idiopathic short stature
    Michael B Ranke
    Paediatric Endocrinology Section, Children s Hospital, University of Tubingen, Tubingen, Germany
    Horm Res 68:53-62. 2007
    ..To develop methods to identify factors associated with a favorable outcome in GH-treated children with idiopathic short stature (ISS)...
  45. ncbi request reprint Postnatal serum insulin-like growth factor I deficiency is associated with retinopathy of prematurity and other complications of premature birth
    Ann Hellstrom
    Goteborg Pediatric Growth Research Center, Department of Pediatrics, Institute of the Health of Women and Children, Sweden
    Pediatrics 112:1016-20. 2003
    ..Because retinopathy of prematurity (ROP) is initiated by abnormal postnatal retinal development, we hypothesized that prolonged low IGF-I in premature infants might be a risk factor for ROP...
  46. doi request reprint Recent anthropometric trends among Swedish school children: evidence for decreasing prevalence of overweight in girls
    Agneta Sjöberg
    Department of Public Health and Community Medicine, Institute of Medicine, Sahlgrenska Academy at Goteborg University, Goteborg, Sweden
    Acta Paediatr 97:118-23. 2008
    ..To assess the recent prevalence of overweight and obesity in 10 year old children in Göteborg, Sweden...
  47. pmc Continuous growth reference from 24th week of gestation to 24 months by gender
    Aimon Niklasson
    Göteborg Pediatric Growth Research Centre, Department of Pediatrics, the Institute for Clinical Sciences at the Sahlgrenska Academy, University of Gothenburg, Goteborg, Sweden
    BMC Pediatr 8:8. 2008
    ..An updated, continuous growth standard that bridges size at birth values with postnatal growth values can improve child growth screening and monitoring...
  48. ncbi request reprint The mathematical model for total pubertal growth in idiopathic growth hormone (GH) deficiency suggests a moderate role of GH dose
    Michael B Ranke
    Pediatric Endocrinology Section, University Children s Hospital, Tubingen D 72076 Germany
    J Clin Endocrinol Metab 88:4748-53. 2003
    ..The use of a higher GH dosage at the onset of puberty should thus depend on the individual's height development. The TPG model aids in the planning of individually optimized and cost-effective GH treatment...
  49. doi request reprint Growth promoting treatment normalizes speech frequency in Turner syndrome
    Gunnel Andersson-Wallgren
    Department of Pediatrics, Göteborg Pediatric Growth Research Centre, Institute of Clinical Sciences, Sahlgrenska Academy, Goteborg University, Goteborg, Sweden
    Laryngoscope 118:1125-30. 2008
    ....
  50. ncbi request reprint Increased response, but lower responsiveness, to growth hormone (GH) in very young children (aged 0-3 years) with idiopathic GH Deficiency: analysis of data from KIGS
    Michael B Ranke
    Pediatric Endocrinology Section, University Children s Hospital, Hoppe Seyler Strasse 1, D 72076 Tuebingen, Germany
    J Clin Endocrinol Metab 90:1966-71. 2005
    ..The early detection and GH treatment of congenital GHD is advantageous as a cost-effective strategy for achieving greater improvement of absolute height and growth velocity...