Dan D Hershko

Summary

Country: Israel

Publications

  1. pmc The mTOR inhibitor rapamycin down-regulates the expression of the ubiquitin ligase subunit Skp2 in breast cancer cells
    Ma anit Shapira
    Department of Surgery A, Rambam Medical Center, Haifa 31096, Israel
    Breast Cancer Res 8:R46. 2006
  2. ncbi Breast-conserving surgery and intraoperative electron radiotherapy in early breast cancer: experience at the Rambam Health Care Campus
    Dan Hershko
    Department of Surgery, Rambam Health Care Campus affiliated with Rappaport Faculty of Medicine, Technion lsrael Institute of Technology, Haifa, Israel
    Isr Med Assoc J 14:550-4. 2012
  3. ncbi Prognostic role of p27Kip1 deregulation in colorectal cancer
    Dan D Hershko
    Department of Surgery, Rambam Medical Center, Haifa, Israel
    Cancer 107:668-75. 2006
  4. ncbi Safety of elective hand surgery following axillary lymph node dissection for breast cancer
    Dan D Hershko
    Department of Surgery A, Breast Health Institute, Rambam Health Care Campus, Haifa, Israel
    Breast J 13:287-90. 2007
  5. ncbi Focused helical CT using rectal contrast material only as the preferred technique for the diagnosis of suspected acute appendicitis: a prospective, randomized, controlled study comparing three different techniques
    Dan D Hershko
    Department of Surgery A, Rambam Medical Center and the Technion Israel Institute of Technology, Haifa, Israel
    Dis Colon Rectum 50:1223-9. 2007
  6. doi Oncogenic properties and prognostic implications of the ubiquitin ligase Skp2 in cancer
    Dan D Hershko
    Department of Surgery and Breast Health Institute, Rambam Health Care Campus and the Technion Israel Institute of Technology, Haifa, Israel
    Cancer 112:1415-24. 2008
  7. ncbi The prognostic impact of the ubiquitin ligase subunits Skp2 and Cks1 in colorectal carcinoma
    Ma anit Shapira
    Department of Surgery, Rambam Medical Center and the Technion Israel Institute of Technology, Haifa, Israel
    Cancer 103:1336-46. 2005
  8. pmc Over-expression of Skp2 is associated with resistance to preoperative doxorubicin-based chemotherapy in primary breast cancer
    Shirly Davidovich
    Department of Surgery A, Rambam Medical Center and the Technion Israel Institute of Technology, 1 Efron Street, Haifa 31096, Israel
    Breast Cancer Res 10:R63. 2008
  9. pmc The expression of the ubiquitin ligase subunit Cks1 in human breast cancer
    Merav Slotky
    Department of Surgery A, Rambam Medical Center and the Technion Israel Institute of Technology, Haifa, Israel
    Breast Cancer Res 7:R737-44. 2005
  10. ncbi Differential effects of doxorubicin treatment on cell cycle arrest and Skp2 expression in breast cancer cells
    Ortal Bar-On
    Department of Surgery A, Rambam Medical Center, Technion Israel Institute of Technology, Haifa, Israel
    Anticancer Drugs 18:1113-21. 2007

Collaborators

Detail Information

Publications30

  1. pmc The mTOR inhibitor rapamycin down-regulates the expression of the ubiquitin ligase subunit Skp2 in breast cancer cells
    Ma anit Shapira
    Department of Surgery A, Rambam Medical Center, Haifa 31096, Israel
    Breast Cancer Res 8:R46. 2006
    ..Rapamycin was found to stabilize p27 levels in breast cancer, but whether this effect is mediated through changes in Skp2 expression is unknown...
  2. ncbi Breast-conserving surgery and intraoperative electron radiotherapy in early breast cancer: experience at the Rambam Health Care Campus
    Dan Hershko
    Department of Surgery, Rambam Health Care Campus affiliated with Rappaport Faculty of Medicine, Technion lsrael Institute of Technology, Haifa, Israel
    Isr Med Assoc J 14:550-4. 2012
    ..Intraoperative electron radiotherapy (IOeRT) is an innovative technique for accelerated partial breast irradiation (APBI) that is applied to selected patients affected by early breast cancer...
  3. ncbi Prognostic role of p27Kip1 deregulation in colorectal cancer
    Dan D Hershko
    Department of Surgery, Rambam Medical Center, Haifa, Israel
    Cancer 107:668-75. 2006
    ....
  4. ncbi Safety of elective hand surgery following axillary lymph node dissection for breast cancer
    Dan D Hershko
    Department of Surgery A, Breast Health Institute, Rambam Health Care Campus, Haifa, Israel
    Breast J 13:287-90. 2007
    ..Based on these findings, the appropriateness of the rigorous precautions and prohibitions regarding the care and use of the ipsilateral upper extremity may need to be reconsidered...
  5. ncbi Focused helical CT using rectal contrast material only as the preferred technique for the diagnosis of suspected acute appendicitis: a prospective, randomized, controlled study comparing three different techniques
    Dan D Hershko
    Department of Surgery A, Rambam Medical Center and the Technion Israel Institute of Technology, Haifa, Israel
    Dis Colon Rectum 50:1223-9. 2007
    ..This study was designed to prospectively compare the efficacy of rectal contrast CT to other commonly used contrast-enhanced and nonenhanced CT techniques for the detection of acute appendicitis...
  6. doi Oncogenic properties and prognostic implications of the ubiquitin ligase Skp2 in cancer
    Dan D Hershko
    Department of Surgery and Breast Health Institute, Rambam Health Care Campus and the Technion Israel Institute of Technology, Haifa, Israel
    Cancer 112:1415-24. 2008
    ..Skp2 may be an attractive target for the development of novel interventional therapy...
  7. ncbi The prognostic impact of the ubiquitin ligase subunits Skp2 and Cks1 in colorectal carcinoma
    Ma anit Shapira
    Department of Surgery, Rambam Medical Center and the Technion Israel Institute of Technology, Haifa, Israel
    Cancer 103:1336-46. 2005
    ..The present study was undertaken to assess the prognostic value of both Skp2 and Cks1 in colorectal carcinoma...
  8. pmc Over-expression of Skp2 is associated with resistance to preoperative doxorubicin-based chemotherapy in primary breast cancer
    Shirly Davidovich
    Department of Surgery A, Rambam Medical Center and the Technion Israel Institute of Technology, 1 Efron Street, Haifa 31096, Israel
    Breast Cancer Res 10:R63. 2008
    ..The purpose of the present study was to examine the role of these proteins as predictors of clinical outcome and response to chemotherapy in locally advanced breast cancer...
  9. pmc The expression of the ubiquitin ligase subunit Cks1 in human breast cancer
    Merav Slotky
    Department of Surgery A, Rambam Medical Center and the Technion Israel Institute of Technology, Haifa, Israel
    Breast Cancer Res 7:R737-44. 2005
    ..The present study was undertaken to examine the role of Cks1 expression in breast cancer and its relation to p27Kip1 and Skp2 expression and to tumor aggressiveness...
  10. ncbi Differential effects of doxorubicin treatment on cell cycle arrest and Skp2 expression in breast cancer cells
    Ortal Bar-On
    Department of Surgery A, Rambam Medical Center, Technion Israel Institute of Technology, Haifa, Israel
    Anticancer Drugs 18:1113-21. 2007
    ....
  11. ncbi Expression of the ubiquitin ligase subunit cyclin kinase subunit 1 and its relationship to S-phase kinase protein 2 and p27Kip1 in prostate cancer
    Ma anit Shapira
    Department of Surgery A, Rambam Medical Center and Technion Israel Institute of Technology, Haifa, Israel
    J Urol 176:2285-9. 2006
    ..S-phase kinase protein 2 was found to be over expressed in aggressive prostate cancers but to our knowledge the role of cyclin dependent kinase subunit 1 in these cancers is unknown...
  12. doi The expression and prognostic significance of Cks1 in salivary cancer
    Rafael M Nagler
    Department of Oral and Maxillofacial Surgery and Oral Biochemistry Laboratory, Rambam Medical Center and Bruce Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    Cancer Invest 27:512-20. 2009
    ..High expression of Cks1 WAS strongly associated with lymph node metastases and poor prognosis and survival. Cks1 alterations may have a significant biological role in the pathogenesis of salivary cancer...
  13. ncbi Regulation of the cell cycle inhibitor p27 and its ubiquitin ligase Skp2 in differentiation of human embryonic stem cells
    Dana Egozi
    Department of Plastic Surgery, Rambam Medical Center and The Ruth and Bruce Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    FASEB J 21:2807-17. 2007
    ..In contrast to somatic cells, which have high levels of Skp2 mainly in S and G2/M, in undifferentiated hESc Skp2 levels were also high in G1. These results point to a potentially important role for p27 regulation in hESc...
  14. ncbi The "Sentinel Chain": a new concept for prediction of axillary node status in breast cancer patients
    Moshe Carmon
    Department of Surgery, Shaare Zedek Medical Center, affiliated with the Faculty of Health Sciences, Ben Gurion University of the Negev, Jerusalem, Israel
    Breast Cancer Res Treat 97:323-8. 2006
    ..The aim of this study was to identify a subgroup of patients with positive SLNs and negative NSNs, on the basis of tumor involvement patterns in multiple radioactive nodes...
  15. ncbi Sentinel lymph node biopsy in early breast cancer: the first 100 cases performed in a teaching institute
    Ahmad Mahajna
    Department of Surgery A, Rambam Medical Center, Technion Faculty of Medicine, Haifa, Israel
    Isr Med Assoc J 5:556-9. 2003
    ..Recently, sentinel lymph node biopsy has emerged as an accurate and minimally invasive tool for predicting the axillary nodal status and has become the standard of care in selected patients with breast cancer...
  16. ncbi Alterations in the expression of the cell cycle regulatory protein cyclin kinase subunit 1 in colorectal carcinoma
    Ma anit Shapira
    Department of Surgery A, Rambam Medical Center, Technion Israel Institute of Technology, Haifa, Israel
    Cancer 100:1615-21. 2004
    ..The essential role of cyclin kinase subunit 1 (Cks1) in Skp2-dependent p27 degradation was recently discovered, but its role in human malignancies is unknown...
  17. doi Outcome of transanal endoscopic microsurgery and adjuvant radiotherapy in patients with T2 rectal cancer
    Simon D Duek
    Unit of Colorectal Surgery, Rambam Medical Center, Haifa, Israel
    Dis Colon Rectum 51:379-84; discussion 384. 2008
    ..The adequacy of such treatment for T2 tumors, however, is still controversial. This study was designed to evaluate our results with local excision of T2 cancers...
  18. ncbi Regulation of APC/C (Cdh1) ubiquitin ligase in differentiation of human embryonic stem cells
    Ortal Bar-On
    Department of Surgery, Ruth and Bruce Rappaport Faculty of Medicine and Research Institute, Technion Israel Institute of Technology, Haifa, Israel
    Cell Cycle 9:1986-9. 2010
    ..In addition, protein kinase activity also appears to contribute to the suppression of APC/C (Cdh1) activity in undifferentiated stem cells, possibly by inhibitory phosphorylation of Cdh1...
  19. ncbi Sentinel lymph node biopsy in thin melanoma patients
    Dan D Hershko
    Department of Surgery, a Rambam Medical Center, Technion Israel Institute of Technology, Haifa, Israel
    J Surg Oncol 93:279-85. 2006
    ..We sought to determine the incidence of positive sentinel lymph nodes in thin melanoma (<or=1.0 mm) patients and if subgroups could be identified with a higher risk of occult nodal disease...
  20. pmc Laparoscopic diagnostic peritoneal lavage (L-DPL): A method for evaluation of penetrating abdominal stab wounds
    Michael M Krausz
    Department of Surgery A, Rambam Medical Center, and the Bruce Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    World J Emerg Surg 1:3. 2006
    ....
  21. ncbi Transanal endoscopic microsurgery for rectal cancer
    Simon D Duek
    Department of Surgery A, Rambam Medical Center, Haifa, Israel
    Isr Med Assoc J 7:435-8. 2005
    ..Transanal endoscopic microsurgery has recently gained acceptance as an alternative minimally invasive surgical technique for the curative management of large rectal adenomas and selected early rectal carcinomas...
  22. doi Cyclin-dependent kinase inhibitor p27 as a prognostic biomarker and potential cancer therapeutic target
    Dan D Hershko
    Department of Surgery and Breast Health Institute, Rambam Health Care Campus and the Technion Israel Institute of Technology, Haifa, Israel
    Future Oncol 6:1837-47. 2010
    ..This article presents the current knowledge on the prognostic significance of p27 expression in cancer and its potential role as a target for future therapy...
  23. ncbi The role of selective computed tomography in the diagnosis and management of suspected acute appendicitis
    Dan D Hershko
    Department of Surgery A, Rambam Medical Center, Haifa, Israel
    Am Surg 68:1003-7. 2002
    ..We believe that CT should be performed routinely in women with suspected appendicitis and selectively in men...
  24. ncbi The role of fine-needle aspiration and intraoperative frozen section in the surgical management of solitary thyroid nodules
    Simon D Duek
    Department of Surgery, Rambam Medical Center and B Rappoport Faculty of Medicine, Technion Israel Institute of Technology, Bat Galim, Haifa
    Surg Today 32:857-61. 2002
    ..We evaluated the role of intraoperative frozen section (FS) in the surgical management of solitary thyroid nodules, as its true value is a subject of some controversy...
  25. ncbi Sepsis upregulates the gene expression of multiple ubiquitin ligases in skeletal muscle
    Curtis J Wray
    Department of Surgery, University of Cincinnati, Cincinnati, OH, USA
    Int J Biochem Cell Biol 35:698-705. 2003
    ....
  26. ncbi IL-1beta stimulates IL-6 production in cultured skeletal muscle cells through activation of MAP kinase signaling pathway and NF-kappa B
    Guangjo Luo
    Department of Surgery, University of Cincinnati, Cincinnati, and Shriners Hospitals for Children, Cincinnati, Ohio 45267, USA
    Am J Physiol Regul Integr Comp Physiol 284:R1249-54. 2003
    ..In addition, the results suggest the IL-1beta regulates muscle IL-6 production at least in part by activating the MAP kinase pathway and NF-kappaB...
  27. ncbi Arsenite inhibits interleukin-6 production in human intestinal epithelial cells by down-regulating nuclear factor-kappaB activity
    Dan D Hershko
    Shriners Hospitals for Children, Cincinnati, OH, USA
    Clin Sci (Lond) 103:381-90. 2002
    ..These results suggest that sodium arsenite inhibits IL-6 production in enterocytes subjected to an inflammatory stimulus, and that this effect, at least in part, reflects down-regulated NF-kappaB activity...
  28. ncbi Sodium arsenite downregulates transcriptional activity of AP-1 and CRE binding proteins in IL-1beta-treated Caco-2 cells by increasing the expression of the transcriptional repressor CREMalpha
    Dan D Hershko
    Shriners Hospitals for Children, Cincinnati, Ohio, USA
    J Cell Biochem 90:627-40. 2003
    ..Because of the multiple important biological functions of IL-6 in the enterocyte and gut mucosa, methods to regulate enterocyte IL-6 production have significant clinical implications...
  29. ncbi Superinduction of IL-6 by cycloheximide is associated with mRNA stabilization and sustained activation of p38 map kinase and NF-kappaB in cultured caco-2 cells
    Dan D Hershko
    Shriners Hospitals for Children, Cincinnati, Ohio, USA
    J Cell Biochem 91:951-61. 2004
    ..Our results suggest that superinduction of IL-6 by cycloheximide in enterocytes results from both increased mRNA stabilization and upregulated transcriptional activity mediated by prolonged activation of the p38 MAP kinase and NF-kappaB...
  30. ncbi IL-1beta activates C/EBP-beta and delta in human enterocytes through a mitogen-activated protein kinase signaling pathway
    Eric S Hungness
    Department of Surgery, University of Cincinnati, 231 Bethesda Avenue, Mail Location 0558, Cincinnati, OH 45267 0558, USA
    Int J Biochem Cell Biol 34:382-95. 2002
    ..The results suggest that members of the CCAAT/enhancer binding protein family of transcription factors are activated in enterocytes during inflammatory conditions characterized by high levels of IL-1beta...